{"id":70145,"date":"2024-04-04T13:32:14","date_gmt":"2024-04-04T06:32:14","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=70145"},"modified":"2025-07-24T13:40:55","modified_gmt":"2025-07-24T06:40:55","slug":"methocel-2-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/methocel-2-5\/","title":{"rendered":"Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9)"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Methocel 2.5 Celon Labs<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Celon Labs – \u1ea4n \u0110\u1ed9 hi\u1ec7n \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam.<\/b><\/p>\n

<\/p>\n

Methocel 2,5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9) l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n
Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n
Thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg)<\/strong>\u00a0c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n
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Methotrexate 2.5mg<\/span><\/li>\n
T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/span><\/p>\n
Tr\u00ecnh b\u00e0y<\/span><\/h3>\n
S\u0110K: \u0110ang c\u1eadp nh\u1eadt<\/span><\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n
Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/span><\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9)<\/span><\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\n
Hai c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng \u0111\u1ed9c l\u1eadp c\u1ee7a <\/span>Methotrexate<\/b>:<\/span><\/p>\n
Ch\u1ed1ng ung th\u01b0:<\/span><\/p>\n
\n
T\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a folate.<\/span><\/li>\n
Nh\u1edd vi\u1ec7c enzyme dihydrofolate reductase b\u1ecb \u1ee9c ch\u1ebf b\u1edfi Methotrexate, l\u00e0m cho n\u1ed3ng \u0111\u1ed9 tetrahydrofolate b\u1ecb gi\u1ea3m, y\u1ebfu t\u1ed1 quan tr\u1ecdng cho t\u1ed5ng h\u1ee3p DNA v\u00e0 RNA.<\/span><\/li>\n
Methotrexate-polyglutamate \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p purine v\u00e0 thymidylate synthase, d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p DNA.<\/span><\/li>\n
Ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o.<\/span><\/li>\n<\/ul>\n
\u1ee8c ch\u1ebf mi\u1ec5n d\u1ecbch:<\/span><\/p>\n
\n
Do enzyme AICAR Transformylase b\u1ecb \u1ee9c ch\u1ebf, qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a adenosine v\u00e0 guanine b\u1ecb c\u1ea3n tr\u1edf, l\u00e0m cho Adenosine t\u00edch t\u1ee5.<\/span><\/li>\n
Adenosine c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00e1ng vi\u00eam, k\u00ecm h\u00e3m s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a t\u1ebf b\u00e0o T, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o B, \u0111\u1ed3ng th\u1eddi gia t\u0103ng \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a t\u1ebf b\u00e0o T CD-95 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t.<\/span><\/li>\n
Enzyme methyltransferase b\u1ecb \u1ee9c ch\u1ebf, kh\u00f4ng cho ph\u00e9p interleukin beta-1 b\u00e1m d\u00ednh v\u00e0o \u0111i\u1ec3m ti\u1ebfp nh\u1eadn tr\u00ean m\u00e0ng t\u1ebf b\u00e0o.<\/span><\/li>\n<\/ul>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n
H\u1ea5p th\u1ee5:<\/span><\/p>\n
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Sinh kh\u1ea3 d\u1ee5ng: 64-90% (gi\u1ea3m khi li\u1ec1u u\u1ed1ng > 25 mg).<\/span><\/li>\n
Tmax: 1-2 gi\u1edd.<\/span><\/li>\n
N\u1ed3ng \u0111\u1ed9 huy\u1ebft thanh: 0,01-0,1\u00b5M (li\u1ec1u u\u1ed1ng 10-15\u00b5g).<\/span><\/li>\n<\/ul>\n
Ph\u00e2n b\u1ed1:<\/span><\/p>\n
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Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: 1L\/kg.<\/span><\/li>\n
Li\u00ean k\u1ebft protein: 46,5-54%.<\/span><\/li>\n<\/ul>\n
Chuy\u1ec3n h\u00f3a:<\/span><\/p>\n
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Chuy\u1ec3n h\u00f3a th\u00e0nh methotrexate polyglutamate \u1edf gan v\u00e0 m\u00f4.<\/span><\/li>\n
Methotrexate polyglutamate th\u1ee7y ph\u00e2n th\u00e0nh methotrexate.<\/span><\/li>\n
M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf chuy\u1ec3n th\u00e0nh 7-hydroxy methotrexate.<\/span><\/li>\n<\/ul>\n
B\u00e0i ti\u1ebft:<\/span><\/p>\n
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80% b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i.<\/span><\/li>\n
3% b\u00e0i ti\u1ebft qua m\u1eadt d\u01b0\u1edbi d\u1ea1ng 7-hydroxy methotrexate.<\/span><\/li>\n<\/ul>\n
Thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9) \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n
Methocel 2.5<\/strong> (Methotrexate Tablets IP 2,5mg) \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh sau:<\/span><\/p>\n
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Ung th\u01b0:<\/span>\n
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Ung th\u01b0 h\u1ea1ch (lo\u1ea1i kh\u00f4ng Hodgkin)<\/span><\/li>\n
Ung th\u01b0 bi\u1ec3u m\u00f4 v\u00fa<\/span><\/li>\n
Ung th\u01b0 bi\u1ec3u m\u00f4: bu\u1ed3ng tr\u1eebng, t\u1ebf b\u00e0o nh\u1ecf \u1edf ph\u1ed5i<\/span><\/li>\n
Kh\u1ed1i u bi\u1ec3u b\u00ec \u1edf \u0111\u1ea7u v\u00e0 c\u1ed5<\/span><\/li>\n
Ung th\u01b0 x\u01b0\u01a1ng kh\u00f4ng di c\u0103n<\/span><\/li>\n<\/ul>\n<\/li>\n
B\u1ec7nh t\u1ef1 mi\u1ec5n:<\/span>\n
\n
B\u1ec7nh v\u1ea9y n\u1ebfn<\/span><\/li>\n
B\u1ec7nh lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng<\/span><\/li>\n
B\u1ec7nh vi\u00eam ru\u1ed9t<\/span><\/li>\n
Vi\u00eam m\u1ea1ch<\/span><\/li>\n
B\u1ec7nh m\u00f4 li\u00ean k\u1ebft<\/span><\/li>\n
Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/span><\/li>\n<\/ul>\n<\/li>\n
Gh\u00e9p t\u1ea1ng:<\/span>\n
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Ph\u00f2ng ng\u1eeba bi\u1ebfn ch\u1ee9ng sau gh\u00e9p t\u1ea1ng<\/span><\/li>\n<\/ul>\n<\/li>\n
B\u1ec7nh kh\u00e1c:<\/span>\n
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Lo\u1ea1n t\u1ea1o m\u00e1u<\/span><\/li>\n
B\u1ec7nh n\u1ea5m mycosis<\/span><\/li>\n
Vi\u00eam da c\u01a1<\/span><\/li>\n
V\u1ea3y ph\u1ea5n \u0111\u1ecf pilaris<\/span><\/li>\n
Ch\u00e0m<\/span><\/li>\n
Sarcoidosis<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9)<\/span><\/h2>\n
Ng\u01b0\u1eddi l\u1edbn:<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Ch\u1ea9n \u0111o\u00e1n<\/span><\/td>\n Li\u1ec1u l\u01b0\u1ee3ng<\/span><\/td>\n T\u1ea7n su\u1ea5t<\/span><\/td>\n<\/tr>\n
Ung th\u01b0 nguy\u00ean b\u00e0o nu\u00f4i<\/span><\/td>\n 15 – 30 mg m\u1ed7i ng\u00e0y<\/span><\/td>\n 5 ng\u00e0y, l\u1eb7p l\u1ea1i 3 – 5 \u0111\u1ee3t<\/span><\/td>\n<\/tr>\n
B\u1ec7nh b\u1ea1ch c\u1ea7u c\u1ea5p d\u00f2ng lympho<\/span><\/td>\n T\u1ea5n c\u00f4ng: 3,3 mg\/m\u00b2 + Prednison 40 – 60 mg\/m\u00b2<\/span><\/td>\n M\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n, 4 – 6 tu\u1ea7n<\/span><\/td>\n<\/tr>\n
Duy tr\u00ec: 20-30mg\/m\u00b2<\/span><\/td>\n Tu\u1ea7n 2 l\u1ea7n<\/span><\/td>\n<\/tr>\n
U lympho kh\u00f4ng Hodgkin<\/span><\/td>\n 10 – 25 mg m\u1ed7i ng\u00e0y<\/span><\/td>\n 4 – 8 ng\u00e0y<\/span><\/td>\n<\/tr>\n
Ung th\u01b0 h\u1ea1ch b\u1ea1ch huy\u1ebft<\/span><\/td>\n 0,625 – 2,5 mg\/kg\/ng\u00e0y<\/span><\/td>\n <\/td>\n<\/tr>\n
U s\u00f9i d\u1ea1ng n\u1ea5m<\/span><\/td>\n 5 – 50 mg<\/span><\/td>\n 1 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<\/tr>\n
B\u1ec7nh v\u1ea3y n\u1ebfn<\/span><\/td>\n 5 – 37,5 mg<\/span><\/td>\n Chia li\u1ec1u ho\u1eb7c li\u1ec1u \u0111\u01a1n h\u00e0ng tu\u1ea7n<\/span><\/td>\n<\/tr>\n
Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/span><\/td>\n 7,5 mg<\/span><\/td>\n 1 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Tr\u1ebb em:<\/span><\/p>\n\n\n\n\n\n\n
Ch\u1ea9n \u0111o\u00e1n<\/span><\/td>\n Li\u1ec1u l\u01b0\u1ee3ng<\/span><\/td>\n T\u1ea7n su\u1ea5t<\/span><\/td>\n<\/tr>\n
B\u1ec7nh b\u1ea1ch c\u1ea7u c\u1ea5p d\u00f2ng lympho<\/span><\/td>\n T\u01b0\u01a1ng \u0111\u01b0\u01a1ng li\u1ec1u ng\u01b0\u1eddi l\u1edbn<\/span><\/td>\n T\u00f9y theo ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb<\/span><\/td>\n<\/tr>\n
Vi\u00eam \u0111a kh\u1edbp d\u1ea1ng th\u1ea5p thi\u1ebfu ni\u00ean<\/span><\/td>\n 10 mg\/m\u00b2<\/span><\/td>\n 1 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<\/tr>\n
B\u1ec7nh v\u1ea3y n\u1ebfn<\/span><\/td>\n 200 – 400 mcg\/kg<\/span><\/td>\n 1 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg) trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n
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Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi Methotrexate.<\/span><\/li>\n
Ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c \u0111ang cho con b\u00fa.<\/span><\/li>\n
R\u1ed1i lo\u1ea1n v\u1ec1 m\u00e1u: gi\u1ea3m s\u1ea3n t\u1ee7y x\u01b0\u01a1ng, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u tr\u1ea7m tr\u1ecdng.<\/span><\/li>\n
B\u1ec7nh gan m\u00e3n t\u00ednh, x\u01a1 gan, vi\u00eam gan do r\u01b0\u1ee3u, nghi\u1ec7n r\u01b0\u1ee3u m\u00e3n t\u00ednh (trong tr\u01b0\u1eddng h\u1ee3p vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p ho\u1eb7c b\u1ec7nh v\u1ea9y n\u1ebfn).<\/span><\/li>\n
Nhi\u1ec5m HIV\/AIDS, r\u1ed1i lo\u1ea1n t\u1ea1o m\u00e1u, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn, ho\u1eb7c x\u1ea1 tr\u1ecb.<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9)<\/span><\/h2>\n
Th\u1eadn tr\u1ecdng<\/span><\/h3>\n
C\u1ea7n theo d\u00f5i:<\/span><\/p>\n
\n
Ch\u1ee9c n\u0103ng gan, th\u1eadn v\u00e0 c\u00e1c th\u00f4ng s\u1ed1 huy\u1ebft h\u1ecdc.<\/span><\/li>\n
D\u1ea5u hi\u1ec7u\/tri\u1ec7u ch\u1ee9ng c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng.<\/span><\/li>\n<\/ul>\n
Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho:<\/span><\/p>\n
\n
Ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m khu\u1ea9n, vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y\/\u0111\u1ea1i tr\u00e0ng, suy nh\u01b0\u1ee3c c\u01a1 th\u1ec3, suy t\u1ee7y, suy gan\/th\u1eadn.<\/span><\/li>\n
Ng\u01b0\u1eddi gi\u00e0 (n\u1ebfu c\u1ea7n ph\u1ea3i h\u1ea1 li\u1ec1u).<\/span><\/li>\n<\/ul>\n
Nguy c\u01a1:<\/span><\/p>\n
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B\u1ec7nh ph\u1ed5i (c\u00f3 th\u1ec3 b\u1ea5t ch\u1ee3t x\u1ea3y ra, k\u1ec3 c\u1ea3 li\u1ec1u th\u1ea5p).<\/span><\/li>\n
Gi\u1ea3m ch\u1ee9c n\u0103ng t\u1ee7y x\u01b0\u01a1ng, ti\u1ec3u c\u1ea7u gi\u1ea3m, vi\u00eam ph\u1ed5i (t\u1ef7 l\u1ec7 cao \u1edf ng\u01b0\u1eddi gi\u00e0).<\/span><\/li>\n
Vi\u00eam gan, x\u01a1 gan, thay \u0111\u1ed5i ch\u1ea5t b\u00e9o gan.<\/span><\/li>\n
Nhi\u1ec5m khu\u1ea9n, ho khan, kh\u00f3 th\u1edf.<\/span><\/li>\n
Ti\u00eau ch\u1ea3y, vi\u00eam lo\u00e9t mi\u1ec7ng (n\u1eb7ng c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn vi\u00eam ru\u1ed9t xu\u1ea5t huy\u1ebft, t\u1eed vong).<\/span><\/li>\n
Ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng (ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Stevens-Johnson…).<\/span><\/li>\n
H\u1ed9i ch\u1ee9ng ly gi\u1ea3i kh\u1ed1i u (ng\u01b0\u1eddi c\u00f3 kh\u1ed1i u t\u0103ng tr\u01b0\u1edfng m\u1ea1nh).<\/span><\/li>\n<\/ul>\n
C\u1ea7n ng\u1eebng \u0111i\u1ec1u tr\u1ecb khi:<\/span><\/p>\n
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X\u00e9t nghi\u1ec7m gan cho k\u1ebft qu\u1ea3 b\u1ea5t th\u01b0\u1eddng<\/span><\/li>\n
C\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh ph\u1ed5i.<\/span><\/li>\n
Vi\u00eam ru\u1ed9t xu\u1ea5t huy\u1ebft.<\/span><\/li>\n
Ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng.<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd:<\/span><\/p>\n
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B\u00e1o c\u00e1o cho b\u00e1c s\u0129 m\u1ecdi tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng khi d\u00f9ng thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg).<\/span><\/li>\n
Y\u00eau c\u1ea7u s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ea7n thi\u1ebft khi c\u00f3 h\u1ed9i ch\u1ee9ng ly gi\u1ea3i kh\u1ed1i u.<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/span><\/h3>\n
T\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p:<\/span><\/p>\n
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Bu\u1ed3n n\u00f4n, n\u00f4n, lo\u00e9t ni\u00eam m\u1ea1c, ch\u00e1n \u0103n.<\/span><\/li>\n
T\u0103ng men gan (ph\u1ed5 bi\u1ebfn).<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng:<\/span><\/p>\n
\n
Gan:<\/span>\n
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Nhi\u1ec5m \u0111\u1ed9c gan (ng\u0103n ng\u1eeba b\u1eb1ng axit folic)<\/span><\/li>\n
Gan x\u01a1, gan nhi\u1ec5m m\u1ee1 (hi\u1ebfm g\u1eb7p)<\/span><\/li>\n<\/ul>\n<\/li>\n
Ni\u00eam m\u1ea1c lo\u00e9t (do ng\u1ed9 \u0111\u1ed9c Methotrexate)<\/span><\/li>\n
To\u00e0n th\u00e2n: T\u00f3c r\u1ee5ng, suy nh\u01b0\u1ee3c, s\u1ed1t<\/span><\/li>\n
H\u1ec7 mi\u1ec5n d\u1ecbch:<\/span>\n
\n
D\u1ec5 b\u1ecb nhi\u1ec5m tr\u00f9ng<\/span><\/li>\n
B\u1ea1ch c\u1ea7u gi\u1ea3m<\/span><\/li>\n<\/ul>\n<\/li>\n
Ti\u00eau h\u00f3a: Xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a<\/span><\/li>\n
T\u1ee5y: Vi\u00eam t\u1ee5y<\/span><\/li>\n
T\u1ee7y x\u01b0\u01a1ng: \u1ee8c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng<\/span><\/li>\n
Kh\u00e1c:<\/span>\n
\n
B\u1ec7nh \u00e1c t\u00ednh (ung th\u01b0)<\/span><\/li>\n
Suy th\u1eadn<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/span><\/h3>\n
Methotrexate g\u1eafn k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Do \u0111\u00f3, c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 thay th\u1ebf Methotrexate kh\u1ecfi protein s\u1ebd l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Methotrexate trong m\u00e1u, d\u1eabn \u0111\u1ebfn nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c. Ngo\u00e0i ra, c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ed9 thanh th\u1ea3i Methotrexate \u1edf th\u1eadn c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Methotrexate.<\/span><\/p>\n
C\u00e1c thu\u1ed1c l\u00e0m t\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c Methotrexate:<\/span><\/p>\n
\n
NSAID<\/span><\/li>\n
Salicylat<\/span><\/li>\n
TMP<\/span><\/li>\n
Penicillin<\/span><\/li>\n
Warfarin<\/span><\/li>\n
Valproate<\/span><\/li>\n
Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton<\/span><\/li>\n
Cyclosporin<\/span><\/li>\n
Cisplatin<\/span><\/li>\n<\/ul>\n
C\u00e1c thu\u1ed1c l\u00e0m gi\u1ea3m h\u1ea5p thu Methotrexate:<\/span><\/p>\n
\n
Aminoglycosid<\/span><\/li>\n
Neomycin<\/span><\/li>\n
Thu\u1ed1c th\u0103m d\u00f2<\/span><\/li>\n<\/ul>\n
T\u01b0\u01a1ng t\u00e1c quan tr\u1ecdng v\u00e0 nghi\u00eam tr\u1ecdng nh\u1ea5t l\u00e0 v\u1edbi NSAID v\u00e0 PPI.<\/span><\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/span><\/h3>\n
Methotrexate tuy\u1ec7t \u0111\u1ed1i ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong thai k\u1ef3 v\u00e0 cho con b\u00fa.<\/span><\/p>\n
Ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n c\u1ea7n s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai k\u00e9p khi d\u00f9ng methotrexate.<\/span><\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n
Qu\u00e1 li\u1ec1u Methotrexate:<\/span><\/p>\n
\n
Li\u1ec1u cao h\u01a1n 500 mg\/ml.<\/span><\/li>\n
Tri\u1ec7u ch\u1ee9ng:mu\u1ed1n n\u00f4n, ni\u00eam m\u1ea1c lo\u00e9t, t\u00f3c r\u1ee5ng, suy nh\u01b0\u1ee3c, s\u1ed1t<\/span><\/li>\n
Nguy c\u01a1: nhi\u1ec5m khu\u1ea9n, b\u1ea1ch c\u1ea7u gi\u1ea3m, ti\u00eau h\u00f3a xu\u1ea5t huy\u1ebft,…<\/span><\/li>\n<\/ul>\n
X\u1eed tr\u00ed:<\/span><\/p>\n
\n
Ngay l\u1eadp t\u1ee9c d\u00f9ng Leucovorin.<\/span><\/li>\n
B\u00f9 n\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7 v\u00e0 ki\u1ec1m h\u00f3a n\u01b0\u1edbc ti\u1ec3u.<\/span><\/li>\n<\/ul>\n
Thu\u1ed1c gi\u1ea3i \u0111\u1ed9c:<\/span><\/p>\n
\n
Leucovorin, Thymidine: gi\u1ea3i c\u1ee9u t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng kh\u1ecfi t\u00e1c \u0111\u1ed9ng \u0111\u1ed9c h\u1ea1i c\u1ee7a MTX.<\/span><\/li>\n
Glucarpidase: chuy\u1ec3n MTX th\u00e0nh ch\u1ea5t kh\u00f4ng \u0111\u1ed9c h\u1ea1i, lo\u1ea1i b\u1ecf MTX nhanh ch\u00f3ng.<\/span><\/li>\n<\/ul>\n
Bi\u1ec7n ph\u00e1p kh\u00e1c:<\/span><\/p>\n
\n
Ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o, truy\u1ec1n m\u00e1u.<\/span><\/li>\n
D\u1eabn l\u01b0u v\u00e0 trao \u0111\u1ed5i d\u1ecbch n\u00e3o t\u1ee7y (qu\u00e1 li\u1ec1u trong t\u1ee7y s\u1ed1ng).<\/span><\/li>\n
D\u00f9ng steroid, thu\u1ed1c gi\u1ea3i \u0111\u1ed9c, \u0111\u00ecnh ch\u1ec9 c\u00e1c thu\u1ed1c c\u1ea3n tr\u1edf \u0111\u1ed9 thanh th\u1ea3i Methotrexate.<\/span><\/li>\n<\/ul>\n
Thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg H\u00e0ng \u1ea4n \u0110\u1ed9) gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n
Thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg) hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n
Tr\u01b0\u1eddng h\u1ee3p thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mg) t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c Methocel 2.5 Celon Labs nh\u01b0:\u00a0<\/span><\/p>\n
T<\/span>hu\u1ed1c Unitrexates<\/span><\/a> (290.000\u0111\/h\u1ed9p) do Korea United Pharm Inc (H\u00e0n Qu\u1ed1c) s\u1ea3n xu\u1ea5t, \u0111i\u1ec1u tr\u1ecb ung th\u01b0 (c\u1ed5 t\u1eed cung, d\u1ea1 con, ph\u1ed5i), b\u1ec7nh b\u1ea1ch c\u1ea7u, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p v\u00e0 v\u1ea3y n\u1ebfn kh\u00f4ng \u0111\u00e1p \u1ee9ng li\u1ec7u ph\u00e1p kh\u00e1c.<\/span><\/p>\n
T<\/span>hu\u1ed1c Metrex tab<\/span><\/a> (3.500.000\u0111\/h\u1ed9p) do Dae Han New Pharm (H\u00e0n Qu\u1ed1c) s\u1ea3n xu\u1ea5t, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa, bu\u1ed3ng tr\u1ee9ng, m\u00e1u, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, n\u1ea5m Mycosis Fungoides, ung th\u01b0 b\u00e0ng quang, \u0111\u1ea7u-c\u1ed5, ph\u1ed5i, sacrom, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p v\u00e0 v\u1ea3y n\u1ebfn.<\/span><\/p>\n
T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Methocel 2.5 (Methotrexate Tablets IP 2,5mgH\u00e0ng \u1ea4n \u0110\u1ed9)?<\/span><\/h2>\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/span><\/td>\n Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/span><\/td>\n<\/tr>\n
Trong m\u1ed9t nghi\u00ean c\u1ee9u cho th\u1ea5y Methotrexate hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng Azathioprine trong \u0111i\u1ec1u tr\u1ecb vi\u00eam da t\u00edm m\u00e3n t\u00ednh nh\u01b0ng an to\u00e0n h\u01a1n v\u00e0 hi\u1ec7u qu\u1ea3 v\u1ec1 chi ph\u00ed.<\/span><\/p>\n
Methotrexate l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ed1ng ung th\u01b0 hi\u1ec7u qu\u1ea3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u lo\u1ea1i ung th\u01b0 kh\u00e1c nhau v\u00e0 m\u1ed9t s\u1ed1 b\u1ec7nh t\u1ef1 mi\u1ec5n d\u1ecbch<\/span><\/td>\n
Kh\u00f4ng s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef \u0111ang trong thai k\u1ef3<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n
\n
Yosra Bedoui, Xavier Guillot, Jimmy S\u00e9lambarom, Pascale Guiraud, Claude Giry, Marie Christine Jaffar-Bandjee, St\u00e9phane Ralandison, Philippe Gasque. (Ng\u00e0y 10 th\u00e1ng 10 n\u0103m 2019). <\/span>Methotrexate an Old Drug with New Tricks<\/span><\/i>. Truy c\u1eadp ng\u00e0y 4 th\u00e1ng 4 n\u0103m 2024, t\u1eeb <\/span>https:\/\/pubmed.ncbi.nlm.nih.gov\/31658782\/<\/span><\/a>\u00a0<\/span><\/li>\n
Przemys\u0142aw Ko\u017ami\u0144ski, Pawe\u0142 Krzysztof Halik, Raphael Chesori, Ewa Gniazdowska. (Ng\u00e0y 14 th\u00e1ng 5 n\u0103m 2020). <\/span>Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers<\/span><\/i>. Truy c\u1eadp ng\u00e0y 4 th\u00e1ng 4 n\u0103m 2024, t\u1eeb <\/span>https:\/\/pubmed.ncbi.nlm.nih.gov\/32423175\/<\/span><\/a>\u00a0<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c Methocel 2.5 Celon Labs \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, b\u1ec7nh t\u1ef1 mi\u1ec5n, ph\u00f2ng ng\u1eeba bi\u1ebfn ch\u1ee9ng sau gh\u00e9p t\u1ea1ng, v\u00e0 c\u00e1c b\u1ec7nh kh\u00e1c<\/p>\n","protected":false},"author":1,"featured_media":70146,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-70145","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/70145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=70145"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/70146"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=70145"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=70145"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=70145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}