﻿{"id":68607,"date":"2024-03-14T17:13:00","date_gmt":"2024-03-14T10:13:00","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=68607"},"modified":"2025-07-24T13:41:12","modified_gmt":"2025-07-24T06:41:12","slug":"castella-90","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/castella-90\/","title":{"rendered":"Castella 90"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m <a href=\"https:\/\/vnras.com\/drug\/castella-90\/\">thu\u1ed1c Castella 90<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Li\u00ean Doanh Stellapharm, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110166823<\/b><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400\">Castella 90 l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n<h3><span style=\"font-weight: 400\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c <strong>Castella 90<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ticagrelor 90mg<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\n<h3><span style=\"font-weight: 400\">Tr\u00ecnh b\u00e0y<\/span><\/h3>\n<p><span style=\"font-weight: 400\">S\u0110K: 893110166823<\/span><\/p>\n<p><span style=\"font-weight: 400\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n<p><span style=\"font-weight: 400\">Xu\u1ea5t x\u1ee9: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\n<h2><span style=\"font-weight: 400\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Castella 90<\/span><\/h2>\n<h3><span style=\"font-weight: 400\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\n<p><span style=\"font-weight: 400\">Ticagrelor li\u00ean k\u1ebft m\u1ea1nh m\u1ebd v\u00e0 thu\u1eadn ngh\u1ecbch v\u1edbi th\u1ee5 th\u1ec3 P2Y12:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ng\u0103n ch\u1eb7n s\u1ef1 g\u1eafn k\u1ebft c\u1ee7a ADP, \u1ee9c ch\u1ebf t\u00edn hi\u1ec7u ADP v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ti\u1ec3u c\u1ea7u.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hi\u1ec7u qu\u1ea3 h\u01a1n clopidogrel trong vi\u1ec7c \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Ticagrelor c\u00f3 t\u00e1c d\u1ee5ng qua trung gian adenosine:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u1ee8c ch\u1ebf s\u1ef1 h\u1ea5p thu adenosine c\u1ee7a t\u1ebf b\u00e0o, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc c\u1ee7a adenosine.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">H\u1ea1n ch\u1ebf t\u1ed5n th\u01b0\u01a1ng tim do thi\u1ebfu m\u00e1u<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Ticagrelor c\u00f3 t\u00e1c d\u1ee5ng \u0111a n\u0103ng kh\u00e1c:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">H\u1ea1n ch\u1ebf di\u1ec7n t\u00edch t\u1ed5n th\u01b0\u01a1ng tim<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Gi\u1ea3m nguy c\u01a1 h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">C\u1ea3i thi\u1ec7n l\u01b0u th\u00f4ng m\u00e1u<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Gi\u1ea3m nguy c\u01a1 bi\u1ebfn ch\u1ee9ng tim m\u1ea1ch<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400\">H\u1ea5p th\u1ee5:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Sinh kh\u1ea3 d\u1ee5ng qua \u0111\u01b0\u1eddng u\u1ed1ng: 36%<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Cmax: 923ng\/mL<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tmax: 1,5 gi\u1edd<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Ph\u00e2n b\u1ed1:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: 88 L<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Li\u00ean k\u1ebft protein: &gt;99%<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Chuy\u1ec3n h\u00f3a:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Chuy\u1ec3n h\u00f3a th\u00e0nh AR-C124910XX (ho\u1ea1t \u0111\u1ed9ng) v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00e1c.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua kh\u1eed alkyl, glucuronid h\u00f3a v\u00e0 hydroxyl h\u00f3a.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Th\u1ea3i tr\u1eeb:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">B\u00e0i ti\u1ebft qua ph\u00e2n (57,8%) v\u00e0 n\u01b0\u1edbc ti\u1ec3u (26,5%).<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">N\u1eeda \u0111\u1eddi trong huy\u1ebft t\u01b0\u01a1ng:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ticagrelor: 8 gi\u1edd<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh: 12 gi\u1edd<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Thu\u1ed1c Castella 90 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u Ticagrelor d\u00f9ng chung v\u1edbi Aspirin c\u00f3 t\u00e1c d\u1ee5ng d\u1ef1 ph\u00f2ng bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i do v\u1eefa x\u01a1 \u0111\u1ed9ng m\u1ea1ch \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u0110\u00e3 t\u1eebng b\u1ecb nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 c\u00f3 nguy c\u01a1 cao h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">H\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p t\u00ednh<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Castella 90<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Li\u1ec1u khuy\u1ebfn c\u00e1o:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">H\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p t\u00ednh: 180mg ban \u0111\u1ea7u, sau \u0111\u00f3 90mg x 2 l\u1ea7n\/ng\u00e0y, t\u1ed1i \u0111a 12 th\u00e1ng.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim: 60mg x 2 l\u1ea7n\/ng\u00e0y, sau 1 n\u0103m c\u00f3 th\u1ec3 t\u0103ng l\u00ean 90mg x 2 l\u1ea7n\/ng\u00e0y.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ng\u01b0\u1eddi cao tu\u1ed5i: Li\u1ec1u l\u01b0\u1ee3ng kh\u00f4ng c\u1ea7n thay \u0111\u1ed5i.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Suy th\u1eadn: Li\u1ec1u l\u01b0\u1ee3ng kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Suy gan:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">N\u1eb7ng: ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Trung b\u00ecnh: th\u1eadn tr\u1ecdng<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tr\u1ebb em: Hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">C\u00e1ch d\u00f9ng:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">U\u1ed1ng thu\u1ed1c c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">C\u00f3 th\u1ec3 nghi\u1ec1n n\u00e1t vi\u00ean thu\u1ed1c n\u1ebfu g\u1eb7p kh\u00f3 kh\u0103n khi nu\u1ed1t.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thu\u1ed1c Castella 90.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Castella 90 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Kh\u00f4ng d\u00f9ng thu\u1ed1c Castella 90 trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Xu\u1ea5t huy\u1ebft do b\u1ec7nh l\u00fd<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Suy gi\u1ea3m ch\u1ee9c n\u0103ng gan nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">D\u1ecb \u1ee9ng v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">C\u00f3 ti\u1ec1n s\u1eed xu\u1ea5t huy\u1ebft trong s\u1ecd.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">U\u1ed1ng Ticagrelor \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Castella 90<\/span><\/h2>\n<ul>\n<li><span style=\"font-weight: 400\">Ng\u01b0\u1eddi c\u00f3 m\u1ee9c \u0111\u1ed9 r\u1ee7i ro ch\u1ea3y m\u00e1u cao c\u1ea7n l\u01b0u \u00fd khi d\u00f9ng thu\u1ed1c.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ng\u01b0ng d\u00f9ng thu\u1ed1c 5 ng\u00e0y tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt kh\u00f4ng c\u1ea5p thi\u1ebft.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Castella 90 trong th\u1eddi gian d\u00e0i h\u01a1n 1 n\u0103m cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9t qu\u1ef5 thi\u1ebfu m\u00e1u n\u00e3o.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ticagrelor ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng gan suy gi\u1ea3m nghi\u00eam tr\u1ecdng.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ng\u01b0\u1eddi b\u1ec7nh suy gan trung b\u00ecnh c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn khi s\u1eed d\u1ee5ng Castella 90<\/span><\/li>\n<li><span style=\"font-weight: 400\">C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Ticagrelor cho tr\u01b0\u1eddng h\u1ee3p c\u00f3 nguy c\u01a1 cao g\u1eb7p bi\u1ebfn c\u1ed1 nh\u1ecbp tim ch\u1eadm.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Theo d\u00f5i nh\u1ecbp tim khi d\u00f9ng chung v\u1edbi thu\u1ed1c l\u00e0m ch\u1eadm nh\u1ecbp tim.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ng\u01b0ng d\u00f9ng thu\u1ed1c n\u1ebfu kh\u00f3 th\u1edf n\u1eb7ng ho\u1eb7c k\u00e9o d\u00e0i.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ki\u1ec3m tra ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i, suy th\u1eadn ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ng\u01b0\u1eddi c\u00f3 t\u0103ng acid uric m\u00e1u ho\u1eb7c b\u1ec7nh g\u00fat tr\u01b0\u1edbc \u0111\u00f3 c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn khi s\u1eed d\u1ee5ng Ticagrelor.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ng\u01b0ng d\u00f9ng thu\u1ed1c v\u00e0 th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 n\u1ebfu c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u tan m\u00e1u vi th\u1ec3, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn ho\u1eb7c s\u1ed1t.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Ticagrelor c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m HIT.<\/span><\/li>\n<li><span style=\"font-weight: 400\">Tr\u00e1nh s\u1eed d\u1ee5ng ticagrelor c\u00f9ng l\u00fac v\u1edbi aspirin li\u1ec1u cao (tr\u00ean 300 mg).<\/span><\/li>\n<li><span style=\"font-weight: 400\">C\u1ea7n ng\u1eebng \u0111i\u1ec1u tr\u1ecb Ticagrelor m\u1ed9t c\u00e1ch t\u1eeb t\u1eeb.<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400\">T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/span><\/h3>\n<p><span style=\"font-weight: 400\">R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Th\u1edf kh\u00f3<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng, xu\u1ea5t huy\u1ebft n\u1ed9i t\u1ea1ng, d\u1ec5 t\u1ee5 m\u00e1u, b\u1ea7m t\u00edm<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Acid uric m\u00e1u t\u0103ng<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Th\u01b0\u1eddng g\u1eb7p<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">N\u00f4n ra m\u00e1u<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Huy\u1ebft \u00e1p th\u1ea5p<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u tr\u1ef1c tr\u00e0ng<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">M\u1ea5t th\u0103ng b\u1eb1ng, hoa m\u1eaft v\u00e0 nh\u1ee9c \u0111\u1ea7u<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vi\u00eam kh\u1edbp do gout\/Gout<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u cam<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Kh\u00f3 ti\u00eau<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u1ec8a ch\u1ea3y<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Bu\u1ed3n n\u00f4n<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u0110i ngo\u00e0i kh\u00f3<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u l\u1ee3i<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u d\u01b0\u1edbi da, v\u1ebft ban \u0111\u1ecf, ng\u1ee9a s\u1ea9n\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">T\u0103ng creatinin m\u00e1u;<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ch\u1ea3y m\u00e1u sau ti\u1ec3u ph\u1eabu, sau ch\u1ea5n th\u01b0\u01a1ng<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ti\u1ec3u ra m\u00e1u<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Xu\u1ea5t huy\u1ebft b\u00e0ng quang<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400\">T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/span><\/h3>\n<table style=\"border-collapse: collapse;width: 100%;height: 252px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;text-align: center;height: 21px\"><span style=\"font-weight: 400\">Thu\u1ed1c<\/span><\/td>\n<td style=\"width: 34.6863%;text-align: center;height: 21px\"><span style=\"font-weight: 400\">T\u01b0\u01a1ng t\u00e1c<\/span><\/td>\n<td style=\"width: 39.7786%;text-align: center;height: 21px\"><span style=\"font-weight: 400\">\u00dd ngh\u0129a l\u00e2m s\u00e0ng<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Midazolam<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">Ticagrelor l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu CYP3A<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Tr\u00e1nh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Simvastatin<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">T\u0103ng Cmax v\u00e0 AUC c\u1ee7a simvastatin<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Nguy c\u01a1 t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a statin<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Ethinyl estradiol &amp; Levonorgestrel<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 ho\u1eb7c \u0111\u1ed9 an to\u00e0n c\u1ee7a thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Venlafaxine<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">T\u0103ng Cmax c\u1ee7a venlafaxine nh\u1eb9<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn chuy\u1ec3n h\u00f3a qua trung gian CYP2D6<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Digoxin<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">T\u0103ng Cmax v\u00e0 AUC c\u1ee7a digoxin<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Theo d\u00f5i l\u00e2m s\u00e0ng v\u00e0\/ho\u1eb7c x\u00e9t nghi\u1ec7m<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng CYP3A m\u1ea1nh (Rifampicin)<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">Gi\u1ea3m Cmax, AUC v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a ticagrelor<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Tr\u00e1nh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh (Ketoconazol, Ritonavir)<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">T\u0103ng Cmax v\u00e0 AUC c\u1ee7a ticagrelor<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Cyclosporine<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">T\u0103ng AUC v\u00e0 Cmax c\u1ee7a ticagrelor<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u ticagrelor<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Heparin &amp; Enoxaparin<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng ch\u00fa \u00fd v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 ho\u1eb7c \u0111\u1ed9 an to\u00e0n<\/span><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 25.4613%;height: 21px\"><span style=\"font-weight: 400\">Clopidogrel<\/span><\/td>\n<td style=\"width: 34.6863%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn ticagrelor<\/span><\/td>\n<td style=\"width: 39.7786%;height: 21px\"><span style=\"font-weight: 400\">Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 ho\u1eb7c \u0111\u1ed9 an to\u00e0n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span style=\"font-weight: 400\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/span><\/h3>\n<p><span style=\"font-weight: 400\">Mang thai:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Kh\u00f4ng n\u00ean d\u00f9ng Ticagrelor khi mang thai v\u00ec ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 an to\u00e0n v\u00e0 c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho thai nhi.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ph\u1ee5 n\u1eef c\u00f3 th\u1ec3 c\u00f3 thai n\u00ean s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong khi d\u00f9ng thu\u1ed1c.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Cho con b\u00fa:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ticagrelor c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 v\u00e0 c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho tr\u1ebb s\u01a1 sinh.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">N\u00ean ng\u1eebng cho con b\u00fa ho\u1eb7c ng\u1eebng d\u00f9ng Ticagrelor.<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<ul data-sourcepos=\"10:1-18:0\">\n<li data-sourcepos=\"10:1-10:33\">Bi\u1ec3u hi\u1ec7n: Kh\u00f3 th\u1edf, ng\u01b0ng th\u1ea5t.<\/li>\n<li data-sourcepos=\"11:1-18:0\">X\u1eed tr\u00ed:\n<ul data-sourcepos=\"12:5-18:0\">\n<li data-sourcepos=\"12:5-12:44\">Ghi nh\u1eadn c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/li>\n<li data-sourcepos=\"13:5-13:33\">Theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 (ECG).<\/li>\n<li data-sourcepos=\"14:5-14:39\">Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u.<\/li>\n<li data-sourcepos=\"15:5-15:41\">H\u1ed7 tr\u1ee3 theo th\u1ef1c h\u00e0nh y khoa chu\u1ea9n.<\/li>\n<li data-sourcepos=\"16:5-16:52\">K\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u do \u1ee9c ch\u1ebf ti\u1ec3u c\u1ea7u.<\/li>\n<li data-sourcepos=\"17:5-18:0\">\u00c1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 n\u1ebfu c\u00f3 xu\u1ea5t huy\u1ebft.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Thu\u1ed1c Castella 90 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c Castella 90 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">Tr\u01b0\u1eddng h\u1ee3p thu\u1ed1c Castella 90 t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c Castella 90 nh\u01b0:\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c <\/span><a href=\"https:\/\/vnras.com\/drug\/thuoc-brilinta-90mg\/\"><span style=\"font-weight: 400\">Brilinta 90mg<\/span><\/a><span style=\"font-weight: 400\"> (Ticagrelor) do AstraZeneca AB (Th\u1ee5y \u0110i\u1ec3n) s\u1ea3n xu\u1ea5t v\u00e0 ph\u00e2n ph\u1ed1i, gi\u00e1 1.200.000\u0111\/h\u1ed9p, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng nguy c\u01a1 huy\u1ebft kh\u1ed1i.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c <\/span><a href=\"https:\/\/vnras.com\/drug\/copedina-75mg\/\"><span style=\"font-weight: 400\">Copedina 75mg<\/span><\/a><span style=\"font-weight: 400\"> (Clopidogrel) do Pharmaceutical Works Adamed Pharma s\u1ea3n xu\u1ea5t, d\u00f9ng d\u1ef1 ph\u00f2ng bi\u1ebfn c\u1ed1 t\u1eafc m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5 ho\u1eb7c b\u1ec7nh m\u1ea1ch ngo\u1ea1i vi.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Castella 90?<\/span><\/h2>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 51.1439%\"><span style=\"font-weight: 400\">\u01afu \u0111i\u1ec3m<\/span><\/td>\n<td style=\"width: 48.7823%\"><span style=\"font-weight: 400\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 51.1439%\"><span style=\"font-weight: 400\">Gi\u1ea3m nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch (nh\u01b0 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5) \u1edf b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p ho\u1eb7c ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Hi\u1ec7u qu\u1ea3 h\u01a1n clopidogrel trong vi\u1ec7c gi\u1ea3m nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch.<\/span><\/p>\n<p><span style=\"font-weight: 400\">D\u1ea1ng vi\u00ean u\u1ed1ng, d\u1ec5 s\u1eed d\u1ee5ng.<\/span><\/td>\n<td style=\"width: 48.7823%\"><span style=\"font-weight: 400\">C\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 kh\u00f3 th\u1edf, nh\u1ee9c \u0111\u1ea7u, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Renli Teng. (Th\u00e1ng 11 n\u0103m 2015). <\/span><i><span style=\"font-weight: 400\">Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update<\/span><\/i><span style=\"font-weight: 400\">. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 3 n\u0103m 2024, t\u1eeb <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26063049\/\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26063049\/<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mohamed Fawzy Kabil, Ahmed S Abo Dena, Ibrahim M El-Sherbiny . (Ng\u00e0y 7 th\u00e1ng 12 n\u0103m 2021). <\/span><i><span style=\"font-weight: 400\">Ticagrelor<\/span><\/i><span style=\"font-weight: 400\">. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 3 n\u0103m 2024, t\u1eeb <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35396017\/\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35396017\/<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Castella 90 l\u00e0 m\u1ed9t thu\u1ed1c hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p ho\u1eb7c ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim<\/p>\n","protected":false},"author":1,"featured_media":68581,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-68607","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/68607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=68607"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/68581"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=68607"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=68607"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=68607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}