{"id":59611,"date":"2023-11-28T23:20:07","date_gmt":"2023-11-28T16:20:07","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=59611"},"modified":"2025-07-24T13:44:04","modified_gmt":"2025-07-24T06:44:04","slug":"thuoc-brilinta-90mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-brilinta-90mg\/","title":{"rendered":"Brilinta 90mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Brilinta 90mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi AstraZeneca AB – Th\u1ee5y \u0110i\u1ec3n v\u00e0 AstraZeneca ch\u1ecbu tr\u00e1ch nhi\u1ec7m \u0111\u0103ng k\u00fd, ph\u00e2n ph\u1ed1i. Brilinta 90mg c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-19006-15, \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng nguy c\u01a1 huy\u1ebft kh\u1ed1i.\u00a0<\/b><\/p>\n

Brilinta 90mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n
Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n
M\u1ed7i vi\u00ean Brilinta 90mg<\/strong> bao g\u1ed3m<\/p>\n
\n
Ticagrelor: 90mg<\/li>\n
T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\n
Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: VN-19006-15.\u00a0<\/span><\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: \u00a0H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n
Xu\u1ea5t x\u1ee9: AstraZeneca AB – Th\u1ee5y \u0110i\u1ec3n<\/span><\/p>\n
\u0110\u01a1n v\u1ecb \u0111\u0103ng k\u00fd: AstraZeneca Vi\u1ec7t Nam.<\/p>\n
Thu\u1ed1c Brilinta 90mg c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/span><\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
Brilinta ch\u1ee9a ticagrelor,\u00a0m\u1ed9t triazolo pyrimidine l\u00e0 m\u1ed9t \u0111\u1ed3ng v\u1ecb adenosine; v\u00f2ng cyclopentane t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ribose v\u00e0 g\u1ed1c triazolo[4,5-d]pyrimidine gi\u00e0u nit\u01a1 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nucleobase Adenine.<\/p>\n
Ticagrelor \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp, \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 P2Y12 ch\u1ecdn l\u1ecdc v\u00e0 t\u01b0\u01a1ng t\u00e1c thu\u1eadn ngh\u1ecbch, ng\u0103n c\u1ea3n qu\u00e1 tr\u00ecnh ho\u1ea1t h\u00f3a v\u00e0 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u ph\u1ee5 thu\u1ed9c P2Y12 qua trung gian ADP adenozin diphosphat.<\/p>\n
Thu\u1ed1c kh\u00f4ng ng\u0103n c\u1ea3n g\u1eafn k\u1ebft v\u1edbi ADP, nh\u01b0ng khi g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 P2Y12 do \u0111\u00f3 c\u00e1c t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n vi\u1ec7c d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u c\u1ea3m \u1ee9ng ADP<\/p>\n
D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
H\u1ea5p thu: Ticagrelor \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng t\u1eeb ru\u1ed9t v\u1edbi sinh kh\u1ea3 d\u1ee5ng l\u00e0 36%. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1,5-3,0 gi\u1edd. T\u00e1c d\u1ee5ng ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u th\u1ea5p v\u00e0o 48 gi\u1edd sau li\u1ec1u cu\u1ed1i c\u00f9ng.<\/p>\n
Chuy\u1ec3n h\u00f3a: Ticagrelor ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP3A4 v\u00e0 \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 n\u00e0o \u0111\u00f3 b\u1edfi CYP3A5. ARC124910XX l\u00e0 m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a ticagrelor, nh\u01b0ng h\u1ee3p ch\u1ea5t g\u1ed1c ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho ph\u1ea7n l\u1edbn t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ec3u c\u1ea7u. S\u1ef1 th\u1ea3i tr\u1eeb th\u00f4ng qua chuy\u1ec3n h\u00f3a \u1edf gan.<\/p>\n
Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a n\u00f3 l\u00e0 kho\u1ea3ng 12 gi\u1edd.<\/p>\n
Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a thu\u1ed1c Brilinta 90mg<\/span><\/h2>\n
Brilinta \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi acid acetylsalicylic (ASA) \u0111\u1ec3 ph\u00f2ng ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i do x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn c\u00f3 H\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p nh\u01b0:<\/p>\n
\n
\u0110au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh<\/li>\n
Nh\u1ed3i m\u00e1u c\u01a1 tim kh\u00f4ng c\u00f3 ST ch\u00eanh l\u00ean<\/li>\n
Nh\u1ed3i m\u00e1u c\u01a1 tim c\u00f3 ST ch\u00eanh l\u00ean: bao g\u1ed3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c can thi\u1ec7p m\u1ea1ch v\u00e0nh qua da (percutaneous coronary intervention – PCI) ho\u1eb7c ph\u1eabu thu\u1eadt b\u1eafc c\u1ea7u m\u1ea1ch v\u00e0nh (coronary artery by-pass grafting – CABG).<\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng – C\u00e1ch d\u00f9ng thu\u1ed1c Brilinta 90mg<\/span><\/h2>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Brilinta 90mg<\/span><\/h3>\n
N\u00ean kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi ch\u1ec9 m\u1ed9t li\u1ec1u n\u1ea1p 2 vi\u00ean m\u1ed7i ng\u00e0y v\u00e0 sau \u0111\u00f3 duy tr\u00ec li\u1ec1u 1 vi\u00ean 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n
B\u1ec7nh nh\u00e2n d\u00f9ng Brilinta c\u0169ng n\u00ean u\u1ed1ng ASA h\u1eb1ng ng\u00e0y, tr\u1eeb khi c\u00f3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ee5 th\u1ec3.<\/p>\n
Sau m\u1ed9t li\u1ec1u kh\u1edfi \u0111\u1ea7u v\u1edbi ASA, n\u00ean d\u00f9ng Brilinta c\u00f9ng v\u1edbi li\u1ec1u duy tr\u00ec ASA l\u00e0 75-100mg\/ng\u00e0y.<\/p>\n
\u1ede b\u1ec7nh nh\u00e2n b\u1ecb h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p, vi\u1ec7c ng\u1eebng s\u1edbm b\u1ea5t k\u1ef3 li\u1ec7u ph\u00e1p ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u n\u00e0o, k\u1ec3 c\u1ea3 Ticagrelor, c\u00f3 th\u1ec3 g\u00e2y t\u0103ng nguy c\u01a1 t\u1eed vong tim m\u1ea1ch, ho\u1eb7c nh\u1ed3i m\u00e1u c\u01a1 tim do b\u1ec7nh l\u00fd ti\u1ec1m \u1ea9n c\u1ee7a b\u1ec7nh nh\u00e2n.Tr\u00e1nh ng\u01b0ng \u0111i\u1ec1u tr\u1ecb s\u1edbm \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n
C\u00f3 th\u1ec3 chuy\u1ec3n \u0111\u1ed5i t\u1eeb clopidogrel sang \u0111i\u1ec1u tr\u1ecb Ticagrelor trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft. Chuy\u1ec3n t\u1eeb prasugrel sang d\u00f9ng Ticagrelor ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n
Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u v\u1edbi b\u1ec7nh nh\u00e2n suy th\u1eadn, ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 suy gan nh\u1eb9<\/p>\n
D\u1eef li\u1ec7u an to\u00e0n \u1edf b\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh v\u00e0 n\u1eb7ng ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u, kh\u00f4ng d\u00f9ng thu\u1ed1c trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y<\/p>\n
Tr\u1ebb em: ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a ticagrelor \u1edf tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i trong ch\u1ec9 \u0111\u1ecbnh \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u1edf ng\u01b0\u1eddi l\u1edbn<\/p>\n
C\u00e1ch s\u1eed d\u1ee5ng thu\u1ed1c Brilinta 90mg hi\u1ec7u qu\u1ea3 nh\u1ea5t<\/span><\/h3>\n
Brilinta 90mg d\u1ea1ng vi\u00ean, d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n
\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 nu\u1ed1t nguy\u00ean vi\u00ean thu\u1ed1c, c\u00f3 th\u1ec3 nghi\u1ec1n vi\u00ean th\u00e0nh b\u1ed9t m\u1ecbn v\u00e0 ph\u00e2n t\u00e1n trong n\u1eeda ly n\u01b0\u1edbc v\u00e0 u\u1ed1ng ngay l\u1eadp t\u1ee9c. Tr\u00e1ng ly b\u1eb1ng n\u1eeda ly n\u01b0\u1edbc v\u00e0 u\u1ed1ng h\u1ebft.<\/p>\n
H\u1ed7n d\u1ecbch c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng qua \u1ed1ng th\u00f4ng d\u1ea1 d\u00e0y (lo\u1ea1i CH8 hay l\u1edbn h\u01a1n), l\u01b0u \u00fd c\u1ea7n ph\u1ea3i tr\u00e1ng \u1ed1ng th\u00f4ng tr\u01b0\u1edbc v\u00e0 sau khi s\u1eed d\u1ee5ng.<\/p>\n
Khuy\u1ebfn c\u00e1o \u0111i\u1ec1u tr\u1ecb l\u00ean \u0111\u1ebfn 12 th\u00e1ng tr\u1eeb khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ng\u01b0ng d\u00f9ng. Kinh nghi\u1ec7m d\u00f9ng thu\u1ed1c k\u00e9o d\u00e0i h\u01a1n 12 th\u00e1ng c\u00f2n gi\u1edbi h\u1ea1n<\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Brilinta 90mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n
Qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi ho\u1ea1t ch\u1ea5t ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf m\u1ee5c t\u00e1 d\u01b0\u1ee3c.<\/p>\n
Tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng<\/p>\n
\u0110ang b\u1ecb ch\u1ea3y m\u00e1u do b\u1ec7nh l\u00fd.ch\u1ec9 \u0111\u1ecbnh v\u1edbi Ticagrelor.<\/p>\n
Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed b\u1ecb ch\u1ea3y m\u00e1u trong s\u1ecd.<\/p>\n
B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n
Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi ticagrelor v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (nh\u01b0 ketoconazol, clarithromycin, nefazodon, ritonavir v\u00e0 atazanavir), v\u00ec d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 m\u1ee9c \u0111\u1ed9 ti\u1ebfp x\u00fac v\u1edbi ticagrelor.<\/p>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Brilinta 90mg<\/span><\/h2>\n
Th\u1eadn tr\u1ecdng<\/span><\/h3>\n
Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n c\u00f3 xu h\u01b0\u1edbng b\u1ecb ch\u1ea3y m\u00e1u (do ph\u1eabu thu\u1eadt\/ch\u1ea5n th\u01b0\u01a1ng, \u0111ang ho\u1eb7c v\u1eeba ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u\u2026); b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n
Theo d\u00f5i y t\u1ebf nghi\u00eam ng\u1eb7t khi ch\u1ec9 \u0111\u1ecbnh ticagrelor cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed t\u0103ng acid uric m\u00e1u ho\u1eb7c b\u1ec7nh gout.<\/p>\n
N\u00ean khuy\u00ean b\u1ec7nh nh\u00e2n th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 v\u00e0 nha s\u0129 bi\u1ebft r\u1eb1ng h\u1ecd \u0111ang d\u00f9ng ticagrelor tr\u01b0\u1edbc khi \u1ea5n \u0111\u1ecbnh b\u1ea5t k\u1ef3 m\u1ed9t cu\u1ed9c ph\u1eabu thu\u1eadt ho\u1eb7c tr\u01b0\u1edbc khi u\u1ed1ng b\u1ea5t k\u1ef3 thu\u1ed1c m\u1edbi n\u00e0o<\/p>\n
Trong tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ec7nh s\u1eafp tr\u1ea3i qua cu\u1ed9c ph\u1eabu thu\u1eadt kh\u00f4ng c\u1ea5p thi\u1ebft v\u00e0 kh\u00f4ng mu\u1ed1n \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, n\u00ean ng\u01b0ng d\u00f9ng thu\u1ed1c t\u1ed1i thi\u1ec3u 7 ng\u00e0y tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/p>\n
Th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n suy th\u1eadn v\u1eeba\/n\u1eb7ng; suy gan nh\u1eb9 v\u00e0 v\u1eeba; b\u1ec7nh nh\u00e2n b\u1ecb block nh\u0129 th\u1ea5t \u0111\u1ed9 2 – 3 ho\u1eb7c b\u1ecb ng\u1ea5t li\u00ean quan nh\u1ecbp tim ch\u1eadm; h\u1ed9i ch\u1ee9ng suy n\u00fat xoang kh\u00f4ng \u0111\u1eb7t \u0111\u01b0\u1ee3c m\u00e1y t\u1ea1o nh\u1ecbp\u2026<\/p>\n
Kh\u00f4ng khuy\u1ebfn c\u00e1o vi\u1ec7c \u0111i\u1ec1u tr\u1ecb h\u01a1n 1 n\u0103m \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/p>\n
Ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng ticagrelor cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ecb hen suy\u1ec5n v\u00e0\/ho\u1eb7c COPD. N\u1ebfu b\u1ec7nh nh\u00e2n b\u00e1o c\u00e1o b\u1ecb c\u01a1n kh\u00f3 th\u1edf m\u1edbi, k\u00e9o d\u00e0i ho\u1eb7c n\u1eb7ng l\u00ean, ph\u1ea3i theo d\u00f5i k\u1ef9 v\u00e0 n\u1ebfu kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c n\u1eefa, ph\u1ea3i ng\u01b0ng d\u00f9ng ticagrelor.<\/p>\n
Vi\u1ec7c \u0111\u1ed9t ng\u1ed9t ng\u01b0ng b\u1ea5t k\u1ef3 li\u1ec7u ph\u00e1p kh\u00e1ng ti\u1ec3u c\u1ea7u, bao g\u1ed3m c\u1ea3 Brilinta, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u0103ng nguy c\u01a1 tim m\u1ea1ch (CV), t\u1eed vong ho\u1eb7c nh\u1ed3i m\u00e1u c\u01a1 tim do c\u00e1c b\u1ec7nh l\u00fd s\u1eb5n c\u00f3 c\u1ee7a b\u1ec7nh nh\u00e2n. Do \u0111\u00f3, tr\u00e1nh \u0111\u1ed9t ng\u1ed9t ng\u1eebng \u0111i\u1ec1u tr\u1ecb.<\/p>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n
Tr\u00ean h\u1ec7 TKTW: Cho\u00e1ng v\u00e1ng, ng\u1ea5t, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t.<\/p>\n
Tr\u00ean h\u1ec7 ti\u00eau h\u00f3a: Xu\u1ea5t huy\u1ebft, n\u00f4n, t\u00e1o b\u00f3n\/\u1ec9a ch\u1ea3y, kh\u00f3 ti\u00eau.<\/p>\n
Tr\u00ean da: Ng\u1ee9a, ph\u00e1t ban, ch\u1ea3y m\u00e1u d\u01b0\u1edbi da\/trong da.<\/p>\n
Tim m\u1ea1ch: H\u1ea1 huy\u1ebft \u00e1p.<\/p>\n
Trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 tr\u00ean hay b\u1ea5t k\u00ec bi\u1ec3u hi\u1ec7n n\u00e0o nghi ng\u1edd l\u00e0 do d\u00f9ng thu\u1ed1c th\u00ec n\u00ean b\u00e1o ngay cho b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c d\u01b0\u1ee3c s\u0129 t\u01b0 v\u1ea5n \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n v\u00e0 x\u1eed tr\u00ed k\u1ecbp th\u1eddi, ch\u00ednh x\u00e1c.<\/p>\n
T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n
D\u00f9ng \u0111\u1ed3ng th\u1eddi ketoconazol v\u1edbi ticagrelor l\u00e0m t\u0103ng 2,4 l\u1ea7n cmax v\u00e0 7,3 l\u1ea7n AUC c\u1ee7a ticagrelor v\u00e0 l\u00e0m gi\u1ea3m 89% Cmax v\u00e0 56% AUC c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n
C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 kh\u00e1c (clarithromycin, nefazodon, ritonavir v\u00e0 atazanavir) c\u0169ng c\u00f3 t\u00e1c \u0111\u1ed9ng t\u01b0\u01a1ng t\u1ef1 v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00f9ng ticagrelor<\/p>\n
Dltiazem v\u1edbi ticagrelor l\u00e0m t\u0103ng 69% Cmax v\u00e0 2,7 l\u00e0n AUC c\u1ee7a ticagrelor, l\u00e0m gi\u1ea3m 38% Cmax v\u00e0 kh\u00f4ng \u0111\u1ed5i AUC c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh<\/p>\n
C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf v\u1eeba CYP3A4 kh\u00e1c (v\u00ed d\u1ee5, amprenavir, aprepitant, erythromycin v\u00e0 fluconazol) c\u0169ng d\u1ef1 ki\u1ebfn c\u00f3 t\u00e1c \u0111\u1ed9ng t\u01b0\u01a1ng t\u1ef1<\/p>\n
D\u00f9ng \u0111\u1ed3ng th\u1eddi rifampicin v\u1edbi ticagrelor l\u00e0m gi\u1ea3m 73% Cmax V\u00e0 86% AUC c\u1ee7a thu\u1ed1c<\/p>\n
Cyclosporin (ch\u1ea5t \u1ee9c ch\u1ebf P-gp v\u00e0 CYP3A): l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a c\u1ee7a ticagrelor (Cmax) g\u00e3p 2,3 l\u00e0n v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) g\u1ea5p 2,8 l\u00e0n<\/p>\n
N\u00f2ng \u0111\u1ed9 ticagrelor t\u0103ng g\u1ea5p 2 l\u1ea7n sau khi ti\u00eau th\u1ee5 m\u1ed9t l\u01b0\u1ee3ng l\u1edbn n\u01b0\u1edbc \u00e9p b\u01b0\u1edfi h\u00e0ng ng\u00e0y (3 X 200 ml)<\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n
Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 v\u1ec1 t\u00e1c d\u1ee5ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c Brilinta 90mg khi s\u1eed d\u1ee5ng tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai, nh\u01b0ng \u0111\u00e3 c\u00f3 nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c v\u1edbi \u0111\u1ed9ng v\u1eadt \u0111ang mang thai. V\u00ec v\u00e2y, kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y trong th\u1eddi gian mang thai.<\/p>\n
Ticagrelor b\u00e0i ti\u1ebft qua \u0111\u01b0\u1eddng s\u1eefa m\u1eb9 c\u00f3 th\u1ec3 g\u00e2y nh\u1eefng nguy c\u01a1 \u0111\u1ed1i v\u1edbi tr\u1ebb. V\u00ec v\u1eady n\u1ebfu d\u00f9ng thu\u1ed1c n\u00ean ng\u1eebng cho con b\u00fa ho\u1eb7c tr\u00e1nh d\u00f9ng thu\u1ed1c trong th\u1eddi gian cho con b\u00fa, c\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi m\u1eb9 v\u00e0 l\u1ee3i \u00edch cho con b\u00fa.<\/p>\n
\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n
Ticagrelor kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u1ec7m tr\u1ecdng l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y.<\/p>\n
Tuy nhi\u00ean \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o ch\u00f3ng m\u1eb7t v\u00e0 nh\u1ea7m l\u1eabn trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb v\u1edbi ticagrelor. V\u00ec th\u1ebf, b\u1ec7nh nh\u00e2n \u0111\u00e3 t\u1eebng b\u1ecb ch\u00f3ng m\u1eb7t v\u00e0 nh\u1ea7m l\u1eabn n\u00ean c\u1ea9n th\u1eadn khi l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n
X\u1eed tr\u00ed qu\u00e1 li\u1ec1u<\/h3>\n
Ticagrelor \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t khi d\u00f9ng c\u00e1c li\u1ec1u \u0111\u01a1n l\u00ean \u0111\u1ebfn 900mg. \u0110\u1ed9c t\u00ednh tr\u00ean h\u1ec7 ti\u00eau h\u00f3a b\u1ecb gi\u1edbi h\u1ea1n theo li\u1ec1u trong m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01a1n t\u0103ng d\u1ea7n li\u1ec1u d\u00f9ng. C\u00e1c ph\u1ea3n \u1ee9ng ngo\u1ea1i \u00fd c\u00f3 \u00fd ngh\u0129a v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n khi d\u00f9ng qu\u00e1 li\u1ec1u bao g\u1ed3m kh\u00f3 th\u1edf v\u00e0 ng\u01b0ng th\u1ea5t<\/p>\n
Khi b\u1ecb qu\u00e1 li\u1ec1u, n\u00ean ghi nh\u1eadn nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u00f3 th\u1ec3 x\u1ea3y ra v\u00e0 c\u1ea7n theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 (ECG). Hi\u1ec7n nay ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c \u0111\u1ed9ng c\u1ee7a ticagrelor v\u00e0 kh\u00f4ng th\u1ec3 ph\u00e2n t\u00e1ch ticagrelor<\/p>\n
\u1ea2nh h\u01b0\u1edfng c\u1ee7a vi\u1ec7c d\u00f9ng qu\u00e1 li\u1ec1u ticagrelor l\u00e0m k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u li\u00ean quan \u0111\u1ebfn \u1ee9c ch\u1ebf ti\u1ec3u c\u1ea7u. N\u1ebfu c\u00f3 xu\u1ea5t huy\u1ebft, n\u00ean ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 th\u00edch h\u1ee3p.<\/p>\n
B\u1ea3o qu\u1ea3n<\/span><\/h3>\n
Kh\u00f4ng b\u1ea3o qu\u1ea3n qu\u00e1 30\u00b0C.<\/p>\n
Thu\u1ed1c Brilinta 90mg gi\u00e1 bao nhi\u00eau? Brilinta 90mg mua \u1edf \u0111\u00e2u?<\/span><\/h2>\n
Thu\u1ed1c Brilinta 90mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 c\u1ee7a s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n
Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f4ng d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 v\u1edbi Brilinta 90mg nh\u01b0:\u00a0<\/span><\/p>\n
\n
<\/li>\n<\/ol>\n
Brilinta 90mg c\u00f3 t\u1ed1t kh\u00f4ng? T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn Brilinta 90mg?<\/span><\/h2>\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/span><\/td>\n Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/span><\/td>\n<\/tr>\n
Brilinta (ticagrelor) l\u00e0 thu\u1ed1c cyclopentyltriazolopyridine \u0111\u1ea7u ti\u00ean trong nh\u00f3m thu\u1ed1c kh\u00e1ng ti\u1ec3u c\u1ea7u m\u1edbi, \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 gi\u1ea3m t\u1ef7 l\u1ec7 bi\u1ebfn c\u1ed1 tim m\u1ea1ch do huy\u1ebft kh\u1ed1i \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p t\u00ednh (ACS), bao g\u1ed3m \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh (UA), nh\u1ed3i m\u00e1u c\u01a1 tim kh\u00f4ng c\u00f3 \u0111o\u1ea1n ST ch\u00eanh l\u00ean (NSTEMI) v\u00e0 c\u01a1 tim c\u00f3 \u0111o\u1ea1n ST ch\u00eanh l\u00ean.<\/p>\n
Ticagrelor l\u00e0 m\u1ed9t ch\u1ea5t kh\u00e1ng ti\u1ec3u c\u1ea7u m\u1ea1nh, t\u00e1c d\u1ee5ng tr\u1ef1c ti\u1ebfp, li\u00ean k\u1ebft thu\u1eadn ngh\u1ecbch v\u00e0 \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 adenosine diphosphate P2Y12 c\u1ee7a ti\u1ec3u c\u1ea7u, \u0111\u1eb7c bi\u1ec7t thu\u1ed1c kh\u00f4ng y\u00eau c\u1ea7u chuy\u1ec3n \u0111\u1ed5i t\u1eeb ti\u1ec1n thu\u1ed1c sang d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh<\/p>\n
C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u0111\u00e3 ch\u1ee9ng minh vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u1edbi Ticagrelor l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 k\u1ebft c\u1ee5c t\u1ed5ng h\u1ee3p g\u1ed3m t\u1eed vong do tim m\u1ea1ch, nh\u1ed3i m\u00e1u c\u01a1 tim (MI) ho\u1eb7c \u0111\u1ed9t qu\u1ef5 so v\u1edbi li\u1ec7u ph\u00e1p clopidogrel v\u00e0 l\u00e0m gi\u1ea3m c\u00e1c ti\u00eau ch\u00ed ph\u1ee5 v\u1ec1 t\u1eed vong do tim m\u1ea1ch v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim ri\u00eang l\u1ebb.<\/p>\n
D\u1ea1ng vi\u00ean n\u00e9n nh\u1ecf g\u1ecdn, d\u1ec5 s\u1eed d\u1ee5ng, li\u1ec1u d\u00f9ng 1 vi\u00ean m\u1ed7i ng\u00e0y, thu\u1eadn ti\u1ec7n v\u00e0 gi\u1ea3m g\u00e1nh n\u1eb7ng d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi b\u1ec7nh<\/p>\n
Thu\u1ed1c c\u00f3 th\u1ec3 d\u00f9ng cho ng\u01b0\u1eddi suy th\u1eadn (k\u1ec3 c\u1ea3 suy th\u1eadn n\u1eb7ng)<\/p>\n
Vi\u1ec7c s\u1eed d\u1ee5ng ticagrelor trong \u0111i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh c\u1ea5p v\u00e0 b\u1ec7nh huy\u1ebft kh\u1ed1i c\u1ea5p t\u00ednh khi k\u1ebft h\u1ee3p v\u1edbi aspirin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh cho hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 nh\u01b0ng an to\u00e0n v\u00e0 \u00edt bi\u1ebfn c\u1ed1 nghi\u00eam tr\u1ecdng h\u01a1n so v\u1edbi clopidogrel v\u00e0 prasugrel<\/p>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0 s\u1ea3n xu\u1ea5t b\u1edfi AstraZeneca, 1 trong nh\u1eefng th\u01b0\u01a1ng hi\u1ec7u D\u01b0\u1ee3c ph\u1ea9m l\u1edbn nh\u1ea5t th\u1ebf gi\u1edbi v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng c\u0169ng nh\u01b0 hi\u1ec7u qu\u1ea3 s\u1ea3n ph\u1ea9m<\/td>\n
So v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng ti\u1ec3u c\u1ea7u truy\u1ec1n th\u1ed1ng, ticagrelor c\u00f3 li\u00ean quan \u0111\u1ebfn t\u1ef7 l\u1ec7 bi\u1ebfn ch\u1ee9ng ch\u1ea3y m\u00e1u n\u1eb7ng v\u00e0\/ho\u1eb7c nh\u1eb9 cao h\u01a1n<\/p>\n
Gi\u00e1 th\u00e0nh s\u1ea3n ph\u1ea9m cao<\/p>\n
Vi\u1ec7c s\u1eed d\u1ee5ng c\u1ea7n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh v\u00e0 theo d\u00f5i y t\u1ebf ch\u1eb7t ch\u1ebd b\u1edfi c\u00e1c chuy\u00ean gia c\u00f3 kinh nghi\u1ec7m do thu\u1ed1c c\u00f3 nhi\u1ec1u bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n
\n
P T. (Ng\u00e0y \u0111\u0103ng: Th\u00e1ng 08 n\u0103m 2013). Brilinta\u2122 (ticagrelor) Tablets.<\/em> Truy c\u1eadp ng\u00e0y 27 th\u00e1ng 11 n\u0103m 2023 t\u1eeb https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3353491\/<\/li>\n
T\u00e1c gi\u1ea3 Luyuan Tao v\u00e0 c\u1ed9ng s\u1ef1 (Ng\u00e0y \u0111\u0103ng: n\u0103m 2022). A Review of the Role of the Antiplatelet Drug Ticagrelor in the Management of Acute Coronary Syndrome, Acute Thrombotic Disease, and Other Diseases<\/em>. Truy c\u1eadp ng\u00e0y 27 th\u00e1ng 11 n\u0103m 2023 t\u1eeb https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9121774\/<\/li>\n
H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Brilinta 90mg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p t\u1ea3i b\u1ea3n PDF t\u1ea1i \u0111\u00e2y<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c Brilinta 90mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i, h\u1ed9p 6 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim<\/p>\n","protected":false},"author":490,"featured_media":59618,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-59611","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/59611","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=59611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/59618"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=59611"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=59611"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=59611"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}