{"id":58697,"date":"2023-11-23T23:52:07","date_gmt":"2023-11-23T16:52:07","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=58697"},"modified":"2025-07-24T13:44:10","modified_gmt":"2025-07-24T06:44:10","slug":"thuoc-spiolto-respimat-2-5mcg-2-5mcg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-spiolto-respimat-2-5mcg-2-5mcg\/","title":{"rendered":"Spiolto Respimat 2.5mcg\/2.5mcg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <\/b><a href=\"https:\/\/vnras.com\/drug\/thuoc-spiolto-respimat-2-5mcg-2-5mcg\/\"><b>Spiolto Respimat 2.5mcg\/2.5mcg<\/b><\/a><b> v\u1edbi th\u00e0nh ph\u1ea7n c\u00f3 ch\u1ee9a Tiotropium v\u00e0 Olodaterol; c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u00e3n c\u01a1 tr\u01a1n ph\u1ebf qu\u1ea3n, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t v\u00e0 ph\u00e2n ph\u1ed1i b\u1edfi Boehringer Ingelheim &#8211; \u0110\u1ee9c v\u00e0 c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 VN3-51-18.\u00a0<\/b><\/p>\n<h2><span style=\"font-weight: 400;\">Spiolto Respimat 2.5mcg\/2.5mcg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"><strong>Thu\u1ed1c<\/strong> <strong>Spiolto Respimat 2.5mcg\/2.5mcg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\">Tiotropium (d\u01b0\u1edbi d\u1ea1ng tiotropium bromide monohydrate): 2.5mcg<\/li>\n<li>Olodaterol (d\u01b0\u1edbi d\u1ea1ng olodaterol hydrocloride): 2.5mcg.<\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 4ml.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">D\u1ea1ng b\u00e0o ch\u1ebf: Dung d\u1ecbch \u0111\u1ec3 h\u00edt.<\/span><\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p><span style=\"font-weight: 400;\">S\u0110K: VN3-51-18.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 \u1ed1ng thu\u1ed1c 4 ml t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 60 nh\u00e1t x\u1ecbt + 01 b\u00ecnh x\u1ecbt<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xu\u1ea5t x\u1ee9: Boehringer Ingelheim &#8211; \u0110\u1ee9c.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p>Thu\u1ed1c Spiolto Respimat l\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a beta2-adrenergic (Olodaterol) v\u00e0 kh\u00e1ng cholinergic (Tiotropium) v\u1edbi t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng l\u00e0m gi\u00e3n c\u01a1 tr\u01a1n ph\u1ebf qu\u1ea3n.<\/p>\n<p><em>Tiotropium<\/em><\/p>\n<p>Tiotropium bromid l\u00e0 m\u1ed9t thu\u1ed1c kh\u00e1ng muscarinic, c\u00f3 c\u1ea5u tr\u00fac amoni b\u1eadc 4 t\u1ed5ng h\u1ee3p, c\u00f3 t\u00e1c d\u1ee5ng gi\u00e3n ph\u1ebf qu\u1ea3n k\u00e9o d\u00e0i. Tiotropium bromid l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng c\u1ea1nh tranh kh\u00f4ng ch\u1ecdn l\u1ecdc t\u1ea1i th\u1ee5 th\u1ec3 muscarinic (M &#8211; M,). Tiotropium bromid \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u00e0 thu\u1eadn ngh\u1ecbch v\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a acetylcholin v\u00e0 c\u00e1c ch\u1ea5t k\u00edch th\u00edch cholinergic kh\u00e1c t\u1ea1i th\u1ee5 th\u1ec3 M\u1ef9 c\u1ee7a h\u1ec7 th\u1ea7n kinh \u0111\u1ed1i giao c\u1ea3m \u1edf c\u01a1 tr\u01a1n c\u1ee7a \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p n\u00ean l\u00e0m gi\u00e3n ph\u1ebf qu\u1ea3n.<\/p>\n<p><em>Olodaterol<\/em><\/p>\n<p>Olodaterol c\u00f3 \u00e1i l\u1ef1c m\u1ea1nh v\u00e0 t\u00ednh ch\u1ecdn l\u1ecdc cao \u0111\u1ed1i v\u1edbi th\u1ee5 th\u1ec3 beta2-adrenergic c\u1ee7a ng\u01b0\u1eddi. C\u00e1c nghi\u00ean c\u1ee9u in vitro cho th\u1ea5y olodaterol c\u00f3 t\u00ednh ch\u1ee7 v\u1eadn tr\u00ean th\u1ee5 th\u1ec3 beta2-adrenergic ma\u0323nh h\u01a1n 241 l\u1ea7n so v\u1edbi th\u1ee5 th\u1ec3 beta1-adrenergic v\u00e0 ma\u0323nh h\u01a1n 2299 l\u1ea7n so v\u1edbi th\u1ee5 th\u1ec3 beta3-adrenergic. T\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd cu\u0309a ch\u00e2\u0301t na\u0300y \u0111\u01b0\u01a1\u0323c ta\u0323o ra nh\u01a1\u0300 kha\u0309 n\u0103ng li\u00ean k\u1ebft v\u00e0 ho\u1ea1t h\u00f3a th\u1ee5 th\u1ec3 beta2-adrenergic sau khi d\u00f9ng t\u1ea1i ch\u1ed7 theo \u0111\u01b0\u1eddng h\u00edt.<\/p>\n<h3><span style=\"font-weight: 400;\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<table style=\"border-collapse: collapse; width: 100%; height: 1085px;\">\n<tbody>\n<tr style=\"height: 309px;\">\n<td style=\"width: 27.4406%; height: 309px;\">H\u1ea5p thu<\/td>\n<td style=\"width: 72.5594%; height: 309px;\">\n<ul>\n<li>Tiotropium<\/li>\n<\/ul>\n<p>D\u01b0\u0303 li\u1ec7u v\u00ea\u0300 ba\u0300i ti\u00ea\u0301t thu\u00f4\u0301c qua n\u01b0\u01a1\u0301c ti\u00ea\u0309u tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh tr\u1ebb tu\u1ed5i cho th\u1ea5y, kho\u1ea3ng 33% li\u1ec1u hi\u0301t va\u0300o t\u01b0\u0300 b\u00ecnh x\u1ecbt h\u1ea1t m\u1ecbn Respimat \u0111\u01b0\u1ee3c h\u00e2\u0301p thu va\u0300o tu\u1ea7n ho\u00e0n. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a dung d\u1ecbch u\u1ed1ng kho\u1ea3ng 2 &#8211; 3%. N\u1ed3ng \u0111\u1ed9 t\u00f4\u0301i \u0111a cu\u0309a tiotropium trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 5 &#8211; 7 ph\u00fat s\u01b0\u0309 du\u0323ng b\u00ecnh x\u1ecbt h\u1ea1t m\u1ecbn Respimat.<\/p>\n<ul>\n<li>Olodaterol<\/li>\n<\/ul>\n<p>Tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a olodaterol sau khi d\u00f9ng da\u0323ng hi\u0301t \u01b0\u1edbc ti\u0301nh kho\u1ea3ng 30%. Tra\u0301i la\u0323i, sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i khi d\u00f9ng da\u0323ng dung d\u1ecbch u\u1ed1ng la\u0300 d\u01b0\u01a1\u0301i 1%. N\u1ed3ng \u0111\u1ed9 t\u00f4\u0301i \u0111a cu\u0309a olodaterol trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 10 \u0111\u1ebfn 20 ph\u00fat s\u01b0\u0309 du\u0323ng b\u00ecnh x\u1ecbt h\u1ea1t m\u1ecbn Respimat.<\/td>\n<\/tr>\n<tr style=\"height: 201px;\">\n<td style=\"width: 27.4406%; height: 201px;\">Ph\u00e2n b\u1ed1<\/td>\n<td style=\"width: 72.5594%; height: 201px;\">\n<ul>\n<li>Tiotropium<\/li>\n<\/ul>\n<p>Tiotropium k\u1ebft h\u1ee3p v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 72% v\u00e0 co\u0301 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 la\u0300 32 l\/kg. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean chu\u1ed9t c\u1ed1ng cho th\u1ea5y tiotropium kh\u00f4ng th\u00e2\u0301m qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u01a1\u0309 b\u1ea5t k\u1ef3 m\u1ee9c \u0111\u1ed9 na\u0300o.<\/p>\n<ul>\n<li>Olodaterol<\/li>\n<\/ul>\n<p>Olodaterol li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 60% v\u00e0 c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 1110 l.<\/td>\n<\/tr>\n<tr style=\"height: 554px;\">\n<td style=\"width: 27.4406%; height: 554px;\">Chuy\u1ec3n h\u00f3a<\/td>\n<td style=\"width: 72.5594%; height: 554px;\">\n<ul>\n<li>Tiotropium<\/li>\n<\/ul>\n<p>I\u0301t \u0111\u01b0\u01a1\u0323c chuy\u00ea\u0309n ho\u0301a. \u0110i\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c th\u00e2\u0301y ro\u0303 khi co\u0301 t\u01a1\u0301i 74% li\u1ec1u du\u0300ng \u0111\u01b0\u01a1\u0300ng t\u0129nh m\u1ea1ch \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb trong n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng bi\u1ebfn \u0111\u1ed5i. Pha\u0309n \u01b0\u0301ng ph\u00e2n c\u0103\u0301t li\u00ean k\u00ea\u0301t ester cu\u0309a tiotropium kh\u00f4ng c\u00e2\u0300n enzym xu\u0301c ta\u0301c, ta\u0323o ra h\u01a1\u0323p ch\u00e2\u0301t ch\u01b0\u0301a nho\u0301m alcol v\u00e0 ph\u00e2\u0300n ac\/id t\u01b0\u01a1ng \u01b0\u0301ng (N-methylscopine v\u00e0 acid dithienylglycolic). C\u1ea3 2 th\u00e0nh ph\u1ea7n n\u00e0y \u0111\u1ec1u kh\u00f4ng g\u1eafn k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 muscarinic.<\/p>\n<p>Th\u1ef1c nghi\u1ec7m in vitro v\u1edbi microsome v\u00e0 t\u1ebf b\u00e0o gan ng\u01b0\u01a1\u0300i cho th\u1ea5y, m\u1ed9t l\u01b0\u1ee3ng thu\u1ed1c (&lt; 20% li\u1ec1u d\u00f9ng \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch) \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u0103\u0300ng qua\u0301 tri\u0300nh oxy ho\u0301a phu\u0323 thu\u00f4\u0323c cytochrome P450 (CYP) 2D6 v\u00e0 3A4, sau \u0111o\u0301 li\u00ean h\u1ee3p v\u1edbi glutathione \u0111\u00ea\u0309 ta\u0323o tha\u0300nh nhi\u00ea\u0300u ch\u00e2\u0301t chuy\u1ec3n h\u00f3a pha II kha\u0301c nhau.<\/p>\n<ul>\n<li>Olodaterol<\/li>\n<\/ul>\n<p>\u0110\u01b0\u1ee3c chuy\u00ea\u0309n ho\u0301a ch\u00ednh b\u1eb1ng con \u0111\u01b0\u1eddng glucuronic ho\u00e1 tr\u1ef1c ti\u1ebfp v\u00e0 O-demethyl h\u00f3a \u1edf nh\u00f3m methoxy ke\u0300m theo pha\u0309n \u01b0\u0301ng li\u00ean h\u1ee3p sau \u0111o\u0301. Trong 6 ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111a\u0303 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh, ch\u1ec9 c\u00f3 s\u1ea3n ph\u1ea9m demethyl h\u00f3a \u01a1\u0309 da\u0323ng ch\u01b0a li\u00ean h\u1ee3p (SOM 1522) co\u0301 kha\u0309 n\u0103ng li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 beta2. Tuy nhi\u00ean, kh\u00f4ng pha\u0301t hi\u1ec7n \u0111\u01b0\u1ee3c ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y trong huy\u1ebft t\u01b0\u01a1ng sau khi du\u0300ng l\u1eb7p la\u0323i nhi\u00ea\u0300u l\u00e2\u0300n li\u1ec1u khuy\u1ebfn c\u00e1o ho\u1eb7c l\u00ean t\u01a1\u0301i 4 l\u1ea7n li\u00ea\u0300u khuy\u00ea\u0301n ca\u0301o.<\/p>\n<p>Ca\u0301c isozyme c\u1ee7a cytochrome P450 bao g\u00f4\u0300m CYP2C9, CYP3C8 cu\u0300ng v\u01a1\u0301i \u0111o\u0301ng go\u0301p kh\u00f4ng \u0111\u00e1ng k\u1ec3 c\u1ee7a CYP3A4, xu\u0301c ta\u0301c cho pha\u0309n \u01b0\u0301ng demethyl h\u00f3a olodaterol, trong khi c\u00e1c isoform c\u1ee7a uridine diphosphate glycosyl transferase g\u00f4\u0300m UGT2B7, UGT1A1, 1A7 v\u00e0 1A9 xu\u0301c ta\u0301c t\u1ea1o th\u00e0nh olodaterol \u2013 glucuronide.<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 27.4406%; height: 21px;\">Th\u1ea3i tr\u1eeb<\/td>\n<td style=\"width: 72.5594%; height: 21px;\">\n<ul>\n<li>Tiotropium<\/li>\n<\/ul>\n<p>Tiotropium \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu b\u0103\u0300ng ba\u0300i ti\u00ea\u0301t nguy\u00ean ve\u0323n qua n\u01b0\u1edbc ti\u1ec3u (74%). \u0110\u1ed9 thanh th\u1ea3i to\u00e0n ph\u1ea7n tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh l\u00e0 880 mL\/ph\u00fat. Khi du\u0300ng da\u0323ng hi\u0301t tr\u00ean b\u1ec7nh nh\u00e2n COPD, ta\u0323i tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u00f3 18,6% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c ba\u0300i ti\u00ea\u0301t qua n\u01b0\u1edbc ti\u1ec3u, ph\u1ea7n c\u00f2n l\u1ea1i chu\u0309 y\u00ea\u0301u la\u0300 l\u01b0\u01a1\u0323ng thu\u00f4\u0301c kh\u00f4ng \u0111\u01b0\u1ee3c h\u1ea5p thu ta\u0323i ru\u1ed9t va\u0300 \u0111\u01b0\u01a1\u0323c th\u1ea3i tr\u1eeb qua ph\u00e2n.<\/p>\n<ul>\n<li>Olodaterol<\/li>\n<\/ul>\n<p>Sau khi du\u0300ng \u0111\u01b0\u01a1\u0300ng t\u0129nh m\u1ea1ch v\u00e0 \u0111\u01b0\u01a1\u0300ng u\u1ed1ng, tr\u00ean 90% li\u1ec1u \u0111\u01b0\u1ee3c ba\u0300i ti\u00ea\u0301t trong t\u01b0\u01a1ng \u1ee9ng 6 nga\u0300y v\u00e0 5 ng\u00e0y. Sau khi d\u00f9ng d\u1ea1ng h\u00edt, ta\u0323i tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh, l\u01b0\u01a1\u0323ng olodaterol nguy\u00ean ve\u0323n \u0111\u01b0\u01a1\u0323c ba\u0300i ti\u00ea\u0301t qua n\u01b0\u1edbc ti\u1ec3u trong khoa\u0309ng th\u01a1\u0300i gian gi\u01b0\u0303a hai l\u00e2\u0300n du\u0300ng thu\u00f4\u0301c tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh \u01b0\u01a1\u0301c ti\u0301nh khoa\u0309ng 5 &#8211; 7% li\u1ec1u d\u00f9ng.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p>Spiolto Respimat \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tri\u0323 gia\u0303n ph\u00ea\u0301 qua\u0309n duy tri\u0300 \u0111\u00ea\u0309 gia\u0309m ca\u0301c tri\u1ec7u ch\u01b0\u0301ng \u01a1\u0309 b\u1ec7nh nh\u00e2n tr\u01b0\u01a1\u0309ng tha\u0300nh bi\u0323 b\u1ec7nh ph\u00f4\u0309i t\u0103\u0301c nghe\u0303n ma\u0323n ti\u0301nh (COPD).<\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg c\u00e1ch s\u1eed d\u1ee5ng nh\u01b0 th\u1ebf n\u00e0o?<\/span><\/h2>\n<h3>C\u00e1ch d\u00f9ng thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg<\/h3>\n<h4>Trong l\u1ea7n d\u00f9ng \u0111\u1ea7u ti\u00ean<\/h4>\n<ol>\n<li>Th\u00e1o r\u1eddi ph\u1ea7n n\u1eafp trong su\u1ed1t b\u1eb1ng c\u00e1ch d\u00f9ng 1 tay \u1ea5n v\u00e0o ch\u1ed1t an to\u00e0n v\u00e0 d\u00f9ng tay c\u00f2n l\u1ea1i k\u00e9o m\u1ea1nh ph\u1ea7n \u0111\u1ebf ra. Trong qu\u00e1 tr\u00ecnh thao t\u00e1c nh\u1edb gi\u1eef n\u1eafp b\u00ecnh x\u1ecbt \u0111\u00f3ng.<\/li>\n<li>L\u1eafp \u1ed1ng thu\u1ed1c v\u00e0o trong b\u00ecnh x\u1ecbt, r\u1ed3i \u0111\u1eb7t b\u00ecnh x\u1ecbt \u1edf n\u01a1i b\u1eb1ng ph\u1eb3ng (m\u1eb7t b\u00e0n) l\u1ea5y tay \u1ea5n m\u1ea1nh cho \u0111\u1ebfn khi \u1ed1ng thu\u1ed1c kh\u1edbp v\u00e0o \u0111\u00fang v\u1ecb tr\u00ed.<\/li>\n<li>L\u1eafp ph\u1ea7n \u0111\u1ebf trong su\u1ed1t v\u1eeba th\u00e1o v\u1ec1 v\u1ecb tr\u00ed c\u0169, n\u1ebfu l\u1eafp \u0111\u00fang ta s\u1ebd nghe th\u1ea5y ti\u1ebfng \u201cc\u00e1ch\u201d.<\/li>\n<li>V\u1eabn gi\u1eef n\u1eafp \u0111\u00f3ng trong khi th\u1ef1c hi\u1ec7n. Xoay ph\u1ea7n \u0111\u1ebf trong su\u1ed1t theo h\u01b0\u1edbng m\u0169i t\u00ean ghi tr\u00ean nh\u00e3n \u0111\u1ebfn khi nghe th\u1ea5y ti\u1ebfng \u201cc\u00e1ch\u201d (kho\u1ea3ng n\u1eeda v\u00f2ng).<\/li>\n<li>M\u1edf n\u1eafp v\u00e0 \u1ea5n v\u00f2i phun thu\u1ed1c theo h\u01b0\u1edbng xu\u1ed1ng m\u1eb7t \u0111\u1ea5t r\u1ed3i \u0111\u00f3ng n\u1eafp l\u1ea1i. L\u1eb7p l\u1ea1i b\u01b0\u1edbc 4,5 cho \u0111\u1ebfn khi th\u1ea5y thu\u1ed1c \u0111\u01b0\u1ee3c phun ra. Khi thu\u1ed1c \u0111\u00e3 phun ra, thao t\u00e1c b\u01b0\u1edbc 4,5 th\u00eam 3 l\u1ea7n n\u1eefa.<\/li>\n<\/ol>\n<h4>S\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y t\u1eeb l\u1ea7n x\u1ecbt th\u1ee9 2<\/h4>\n<p>Sau khi xoay ph\u1ea7n \u0111\u1ebf trong su\u1ed1t theo h\u01b0\u1edbng m\u0169i t\u00ean tr\u00ean nh\u00e3n \u0111\u1ebfn khi nghe th\u1ea5y ti\u1ebfng c\u00e1ch th\u00ec m\u1edbi b\u1eaft \u0111\u1ea7u m\u1edf n\u1eafp b\u00ecnh x\u1ecbt.<\/p>\n<ol>\n<li>B\u1ec7nh nh\u00e2n ti\u1ebfn h\u00e0nh th\u1edf ra t\u1eeb t\u1eeb v\u00e0 g\u1eafng s\u1ee9c.<\/li>\n<li>Ng\u1eadm v\u00e0o \u0111\u1ea7u \u1ed1ng phun thu\u1ed1c nh\u01b0ng kh\u00f4ng \u0111\u01b0\u1ee3c che l\u1ed7 th\u00f4ng kh\u00ed.<\/li>\n<li>Th\u1ef1c hi\u1ec7n h\u00edt v\u00e0o ch\u1eadm v\u00e0 s\u00e2u b\u1eb1ng mi\u1ec7ng, r\u1ed1i nh\u1ea5n n\u00fat x\u1ecbt v\u00e0 ti\u1ebfp t\u1ee5c h\u00edt v\u00e0o.<\/li>\n<li>Ng\u1eebng th\u1edf kho\u1ea3ng 10 gi\u00e2y ho\u1eb7c trong th\u1eddi gian l\u00e2u nh\u1ea5t c\u00f3 th\u1ec3 m\u00e0 b\u1ea1n v\u1eabn th\u1ea5y tho\u1ea3i m\u00e1i.<\/li>\n<li>L\u1eb7p l\u1ea1i c\u00e1c b\u01b0\u1edbc tr\u00ean cho \u0111\u1ebfn khi \u0111\u1ee7 li\u1ec1u \u0111i\u1ec1u tr\u1ecb, th\u00f4ng th\u01b0\u1eddng l\u00e0 2 nh\u00e1t x\u1ecbt.<\/li>\n<\/ol>\n<p><em>C\u00e1ch v\u1ec7 sinh \u1ed1ng Spiolto Respimat<\/em><\/p>\n<p>D\u00f9ng v\u1ea3i ho\u1eb7c kh\u0103n gi\u1ea5y \u1ea9m lau s\u1ea1ch ph\u1ea7n \u1ed1ng ng\u1eadm mi\u1ec7ng bao g\u1ed3m c\u1ea3 ph\u1ea7n kim lo\u1ea1i b\u00ean trong \u1ed1ng. M\u1ed9t tu\u1ea7n ph\u1ea3i lau t\u1ed1i thi\u1ec3u 1 l\u1ea7n \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o v\u1ec7 sinh.<\/p>\n<p>N\u1ebfu c\u00f3 s\u1ef1 \u0111\u1ed5i m\u00e0u nh\u1eb9 \u1ed1ng ng\u1eadm, b\u1ea1n kh\u00f4ng n\u00ean qu\u00e1 lo l\u1eafng v\u00ec \u0111i\u1ec1u \u0111\u00f3 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/p>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg<\/h3>\n<p>Ng\u01b0\u1eddi l\u1edbn: Li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng d\u00e0nh cho ng\u01b0\u1eddi l\u1edbn: m\u1ed7i ng\u00e0y 1 l\u1ea7n, m\u1ed7i l\u1ea7n 2 nh\u00e1t x\u1ecbt.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i v\u1eabn c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng thu\u1ed1c theo li\u1ec1u d\u00f9ng nh\u01b0 tr\u00ean n\u1ebfu kh\u00f4ng m\u1eafc c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 gan ho\u1eb7c th\u1eadn n\u1eb7ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 ho\u1eb7c trung b\u00ecnh d\u00f9ng theo li\u1ec1u khuy\u1ebfn c\u00e1o, c\u00f2n \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi suy gan n\u1eb7ng d\u00f9ng theo s\u1ef1 h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn: Ng\u01b0\u1eddi c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn k\u00e9m v\u1eabn c\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c \u1edf li\u1ec1u khuy\u1ebfn c\u00e1o. Tuy nhi\u00ean, c\u1ea7n ph\u1ea3i ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn \u1edf m\u1ee9c \u0111\u1ed9 trung b\u00ecnh ho\u1eb7c n\u1eb7ng do triotropium th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn.<\/p>\n<p>Tr\u1ebb em: Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 li\u1ec1u d\u00f9ng Spiolto Respimat cho tr\u1ebb em trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u00e3n t\u00ednh. \u0110\u1ed3ng th\u1eddi t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a thu\u1ed1c c\u0169ng ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 ch\u00ednh x\u00e1c tr\u00ean nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y. Do \u0111\u00f3, tr\u1ebb em ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c khi c\u00f3 s\u1ef1 ch\u1ec9 \u0111\u1ecbnh t\u1eeb b\u00e1c s\u0129 v\u1edbi li\u1ec1u d\u00f9ng t\u01b0\u01a1ng \u1ee9ng.<\/p>\n<h2><span style=\"font-weight: 400;\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p>B\u1ec7nh nh\u00e2n co\u0301 ti\u00ea\u0300n s\u01b0\u0309 qu\u00e1 m\u1eabn v\u1edbi tiotropium, olodaterol ho\u1eb7c b\u1ea5t k\u1ef3 ta\u0301 d\u01b0\u01a1\u0323c n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n co\u0301 ti\u00ea\u0300n s\u01b0\u0309 qu\u00e1 m\u1eabn v\u1edbi atropine ho\u1eb7c c\u00e1c d\u1eabn ch\u1ea5t c\u1ee7a n\u00f3 nh\u01b0 ipratropium ho\u1eb7c oxitropium.<\/p>\n<h2><span style=\"font-weight: 400;\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u1eadn tr\u1ecdng<\/span><\/h3>\n<ul>\n<li>Th\u1eadn tr\u1ecdng chung<\/li>\n<\/ul>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Spiolto Respimat nhi\u1ec1u h\u01a1n 1 l\u00e2\u0300n m\u00f4\u0303i ng\u00e0y.<\/p>\n<p>Thu\u1ed1c Spiolto Respimat kh\u00f4ng n\u00ean ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi b\u1ecb hen. \u0110\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a Spiolto Respimat tr\u00ean b\u1ec7nh nh\u00e2n hen ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u01b0\u0301u.<\/p>\n<ul>\n<li>Co th\u1eaft ph\u1ebf qu\u1ea3n c\u1ea5p<\/li>\n<\/ul>\n<p>Spiolto Respimat kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u00ea\u0309 \u0111i\u1ec1u tr\u1ecb c\u01a1n co th\u1eaft ph\u1ebf qu\u1ea3n c\u00e2\u0301p, ngh\u0129a la\u0300 kh\u00f4ng \u0111\u01b0\u01a1\u0323c s\u01b0\u0309 du\u0323ng la\u0300m thu\u00f4\u0301c c\u0103\u0301t c\u01a1n.<\/p>\n<ul>\n<li>Qu\u00e1 m\u1eabn<\/li>\n<\/ul>\n<p>T\u01b0\u01a1ng t\u1ef1 t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c kh\u00e1c, ph\u1ea3n \u1ee9ng qua\u0301 m\u00e2\u0303n co\u0301 th\u00ea\u0309 xu\u00e2\u0301t hi\u00ea\u0323n ngay sau khi s\u1eed d\u1ee5ng Spiolto Respimat.<\/p>\n<ul>\n<li>Co th\u1eaft ph\u1ebf qu\u1ea3n ngh\u1ecbch th\u01b0\u1eddng<\/li>\n<\/ul>\n<p>T\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c thu\u1ed1c da\u0323ng h\u00edt kh\u00e1c, Spiolto Respimat c\u00f3 th\u1ec3 g\u00e2y co th\u1eaft ph\u1ebf qu\u1ea3n ngh\u1ecbch th\u01b0\u1eddng \u0111e d\u1ecda t\u00ednh m\u1ea1ng. N\u1ebfu xu\u00e2\u0301t hi\u00ea\u0323n co th\u1eaft ph\u1ebf qu\u1ea3n ngh\u1ecbch th\u01b0\u1eddng, n\u00ean ng\u1eebng thu\u00f4\u0301c ngay l\u00e2\u0323p t\u01b0\u0301c v\u00e0 s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p thay th\u1ebf.<\/p>\n<p>T\u0103ng nh\u00e3n \u00e1p g\u00f3c h\u1eb9p, t\u0103ng sinh tuy\u1ebfn ti\u1ec1n li\u1ec7t ho\u1eb7c t\u1eafc ngh\u1ebdn c\u1ed5 b\u00e0ng quang.<\/p>\n<p>Do \u0111\u1eb7c t\u00ednh kh\u00e1ng cholinergic c\u1ee7a tiotropium, c\u1ea7n s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng Spiolto Respimat tr\u00ean b\u1ec7nh nh\u00e2n t\u0103ng nh\u00e3n \u00e1p g\u00f3c \u0111o\u0301ng, t\u0103ng sinh tuy\u1ebfn ti\u1ec1n li\u1ec7t, ho\u1eb7c t\u1eafc ngh\u1ebdn c\u1ed5 b\u00e0ng quang.<\/p>\n<ul>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/li>\n<\/ul>\n<p>Do n\u00f4\u0300ng \u0111\u1ed9 trong huy\u00ea\u0301t t\u01b0\u01a1ng cu\u0309a tiotropiumm t\u0103ng l\u00ean khi ch\u01b0\u0301c n\u0103ng th\u1eadn gia\u0309m \u01a1\u0309 b\u1ec7nh nh\u00e2n suy th\u1eadn trung bi\u0300nh \u0111\u00ea\u0301n n\u1eb7ng (\u0111\u1ed9 thanh tha\u0309i creatinine \u2264 50 mL\/phu\u0301t), chi\u0309 n\u00ean du\u0300ng Spiolto Respimat khi l\u01a1\u0323i i\u0301ch mong \u0111\u01a1\u0323i v\u01b0\u01a1\u0323t tr\u00f4\u0323i nguy c\u01a1 co\u0301 th\u00ea\u0309 xa\u0309y ra.<\/p>\n<p>Ch\u01b0a co\u0301 kinh nghi\u1ec7m s\u01b0\u0309 du\u0323ng thu\u00f4\u0301c l\u00e2u da\u0300i tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (xem mu\u0323c \u0110\u1eb7c \u0111i\u00ea\u0309m d\u01b0\u01a1\u0323c \u0111\u1ed9ng ho\u0323c).<\/p>\n<ul>\n<li>Tri\u1ec7u ch\u1ee9ng tr\u00ean m\u1eaft<\/li>\n<\/ul>\n<p>B\u1ec7nh nh\u00e2n ph\u1ea3i \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng Spiolto Respimat \u0111u\u0301ng ca\u0301ch.<\/p>\n<p>Ph\u1ea3i th\u1eadn tro\u0323ng, kh\u00f4ng \u0111\u01b0\u01a1\u0323c \u0111\u00ea\u0309 dung d\u1ecbch ho\u1eb7c kh\u00ed dung h\u1ea1t m\u1ecbn bay v\u00e0o m\u1eaft.<\/p>\n<p>\u0110au m\u1eaft ho\u1eb7c c\u1ea3m gi\u00e1c kh\u00f3 ch\u1ecbu, nh\u00ecn m\u1edd, nh\u00ecn qu\u1ea7ng s\u00e1ng ho\u1eb7c h\u00ecnh \u1ea3nh c\u00f3 nhi\u1ec1u m\u00e0u s\u1eafc ke\u0300m theo m\u1eaft \u0111\u1ecf do sung huy\u1ebft k\u00ea\u0301t m\u1ea1c v\u00e0 ph\u00f9 n\u1ec1 gi\u00e1c m\u1ea1c c\u00f3 th\u1ec3 l\u00e0 d\u1ea5u hi\u1ec7u c\u1ee7a t\u0103ng nh\u00e3n \u00e1p g\u00f3c h\u1eb9p c\u1ea5p.<\/p>\n<p>N\u00ean kh\u00e1m chuy\u00ean khoa ngay n\u1ebfu xu\u1ea5t hi\u1ec7n b\u1ea5t k\u1ef3 s\u1ef1 k\u1ebft h\u1ee3p n\u00e0o c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00eau tr\u00ean.<\/p>\n<p>C\u00e1c thu\u1ed1c nh\u1ecf m\u1eaft g\u00e2y co \u0111\u00f4\u0300ng t\u01b0\u0309 kh\u00f4ng \u0111\u01b0\u01a1\u0323c c\u00e2n nh\u0103\u0301c trong \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean.<\/p>\n<ul>\n<li>\u1ea2nh h\u01b0\u1edfng tr\u00ean tim m\u1ea1ch<\/li>\n<\/ul>\n<p>Spiolto Respimat ch\u1ee9a m\u1ed9t ch\u00e2\u0301t ch\u1ee7 v\u1eadn beta2-adrenergic t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i.<\/p>\n<p>C\u00e1c ch\u00e2\u0301t ch\u1ee7 v\u1eadn beta2-adrenergic t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng tr\u00ean b\u1ec7nh nh\u00e2n m\u0103\u0301c b\u1ec7nh tim m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t la\u0300 suy m\u1ea1ch v\u00e0nh, lo\u1ea1n nh\u1ecbp tim, b\u00ea\u0323nh c\u01a1 tim ph\u00ec \u0111\u1ea1i t\u1eafc ngh\u1ebdn v\u00e0 t\u0103ng huy\u1ebft \u00e1p; tr\u00ean b\u1ec7nh nh\u00e2n m\u1eafc ch\u1ee9ng co gi\u1eadt ho\u1eb7c nhi\u1ec5m \u0111\u1ed9c gi\u00e1p, b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed ho\u1eb7c nghi ng\u1edd co\u0301 kho\u1ea3ng QT ke\u0301o da\u0300i, b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u00e1p \u1ee9ng b\u00e2\u0301t th\u01b0\u01a1\u0300ng v\u1edbi c\u00e1c amin c\u01b0\u1eddng giao c\u1ea3m.<\/p>\n<p>T\u01b0\u01a1ng t\u01b0\u0323 c\u00e1c ch\u00e2\u0301t ch\u1ee7 v\u1eadn beta2-adrenergic kh\u00e1c, olodaterol c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng tr\u00ean tim ma\u0323ch co\u0301 y\u0301 nghi\u0303a l\u00e2m sa\u0300ng \u01a1\u0309 m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, bi\u00ea\u0309u hi\u1ec7n b\u0103\u0300ng t\u0103ng nh\u1ecbp tim, t\u0103ng huy\u1ebft \u00e1p v\u00e0\/ho\u1eb7c c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m sa\u0300ng.<\/p>\n<p>Co\u0301 th\u00ea\u0309 c\u1ea7n ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c khi \u1ea3nh h\u01b0\u1edfng na\u0300y xu\u1ea5t hi\u1ec7n. H\u01a1n n\u1eefa, c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta2-adrenergic \u0111a\u0303 \u0111\u01b0\u1ee3c ghi nh\u1eadn la\u0300 nguy\u00ean nh\u00e2n g\u00e2y ra nh\u01b0\u0303ng thay \u0111\u1ed5i tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 (ECG), nh\u01b0 l\u00e0m d\u1eb9t s\u00f3ng T v\u00e0 \u0111oa\u0323n ST ch\u00eanh xu\u1ed1ng, m\u1eb7c d\u00f9 y\u0301 nghi\u0303a l\u00e2m sa\u0300ng cu\u0309a nh\u01b0\u0303ng ghi nh\u1eadn na\u0300y ch\u01b0a ro\u0303 ra\u0300ng.<\/p>\n<ul>\n<li>H\u1ea1 kali huy\u1ebft<\/li>\n<\/ul>\n<p>C\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta2-adrenergic c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 kali huy\u1ebft \u0111a\u0301ng k\u00ea\u0309 tr\u00ean m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng d\u1eabn \u0111\u1ebfn nh\u01b0\u0303ng ta\u0301c du\u0323ng b\u00e2\u0301t l\u01a1\u0323i tr\u00ean tim ma\u0323ch.<\/p>\n<p>Gia\u0309m n\u00f4\u0300ng \u0111\u1ed9 kali huy\u1ebft thanh th\u01b0\u1eddng tho\u00e1ng qua va\u0300 kh\u00f4ng y\u00eau c\u00e2\u0300u b\u1ed5 sung kali. B\u1ec7nh nh\u00e2n COPD n\u1eb7ng c\u00f3 kh\u1ea3 n\u0103ng h\u1ea1 kali huy\u00ea\u0301t do t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy v\u00e0 ca\u0301c \u0111i\u1ec1u tr\u1ecb ke\u0300m theo d\u00e2\u0303n \u0111\u00ea\u0301n t\u0103ng nh\u1ea1y c\u1ea3m v\u1edbi lo\u1ea1n nh\u1ecbp tim.<\/p>\n<ul>\n<li>T\u0103ng \u0111\u01b0\u1eddng huy\u1ebft<\/li>\n<\/ul>\n<p>C\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta2-adrenergic da\u0323ng hi\u0301t li\u1ec1u cao c\u00f3 th\u1ec3 g\u00e2y t\u0103ng n\u00f4\u0300ng \u0111\u00f4\u0323 \u0111\u01b0\u1eddng huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<ul>\n<li>Khi du\u0300ng cu\u0300ng ca\u0301c thu\u1ed1c g\u00e2y m\u00ea<\/li>\n<\/ul>\n<p>C\u00e2\u0300n th\u1eadn tro\u0323ng trong tr\u01b0\u01a1\u0300ng h\u01a1\u0323p co\u0301 k\u00ea\u0301 hoa\u0323ch ph\u00e2\u0303u thu\u1eadt s\u01b0\u0309 du\u0323ng thu\u00f4\u0301c g\u00e2y m\u00ea hydrocarbon halogen hoa\u0301 do s\u01b0\u0323 t\u0103ng nha\u0323y ca\u0309m v\u01a1\u0301i ca\u0301c ta\u0301c du\u0323ng phu\u0323 tr\u00ean tim ma\u0323ch cu\u0309a ca\u0301c thu\u00f4\u0301c gia\u0303n ph\u00ea\u0301 qua\u0309n chu\u0309 v\u1eadn beta.<\/p>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Spiolto Respimat \u0111\u00f4\u0300ng th\u01a1\u0300i v\u1edbi ca\u0301c thu\u1ed1c kh\u00e1c ch\u1ee9a ch\u1ea5t ch\u1ee7 v\u1eadn beta2-adrenergic t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i. Nh\u01b0\u0303ng b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng th\u01b0\u1eddng xuy\u00ean ca\u0301c ch\u00e2\u0301t ch\u1ee7 v\u1eadn beta2-adrenergic t\u00e1c d\u1ee5ng ng\u1eafn d\u1ea1ng h\u00edt (vi\u0301 du\u0323 4 l\u1ea7n\/ng\u00e0y) c\u1ea7n \u0111\u01b0\u1ee3c khuy\u00ea\u0301n ca\u0301o chi\u0309 s\u1eed d\u1ee5ng ca\u0301c ta\u0301c nh\u00e2n na\u0300y \u0111\u00ea\u0309 l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng h\u00f4 h\u1ea5p c\u1ea5p.<\/p>\n<p><span style=\"font-size: 20.16px; color: #333333;\">T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/p>\n<p>\u1ea2nh h\u01b0\u1edfng chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: m\u1ea5t n\u01b0\u1edbc.<\/p>\n<p>Tr\u00ean h\u1ec7 th\u1ea7n kinh: ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7.<\/p>\n<p>H\u1ec7 tim m\u1ea1ch: rung nh\u0129, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, nh\u1ecbp tim nhanh, t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>H\u00f4 h\u1ea5p: ho, vi\u00eam h\u1ecdng, vi\u00eam xoang, co th\u1eaft ph\u1ebf qu\u1ea3n, ph\u00e1t \u00e2m kh\u00f3.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a: kh\u00f4 mi\u1ec7ng, t\u00e1o b\u00f3n, nhi\u1ec5m n\u1ea5m h\u1ea7u h\u1ecdng, vi\u00eam mi\u1ec7ng, t\u1eafc ru\u1ed9t, t\u00e1o b\u00f3n, tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n.<\/p>\n<p>Tr\u00ean da v\u00e0 t\u1ed5 ch\u1ee9c d\u01b0\u1edbi da; ng\u1ee9a, ph\u00e1t ban, n\u1ed5i m\u00e0y \u0111ay, nhi\u1ec5m tr\u00f9ng da v\u00e0 lo\u00e9t da, kh\u00f4 da.<\/p>\n<p>R\u1ed1i lo\u1ea1n c\u01a1 x\u01b0\u01a1ng kh\u1edbp: \u0111au l\u01b0ng, s\u01b0ng kh\u1edbp, \u0111au kh\u1edbp.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng th\u1eadn v\u00e0 h\u1ec7 ti\u1ebft ni\u1ec7u: b\u00ed ti\u1ec3u, ti\u1ec3u kh\u00f3 v\u00e0 nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ni\u1ec7u<\/p>\n<h3><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n<p>M\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ch\u00ednh th\u1ee9c ch\u01b0a \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, tiotropium bromide \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c th\u01b0\u1eddng du\u0300ng trong \u0111i\u1ec1u tr\u1ecb COPD nh\u01b0 methylxanthine, steroid \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 steroid da\u0323ng h\u00edt m\u00e0 kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u00ea\u0300 vi\u00ea\u0323c xa\u0309y ra t\u01b0\u01a1ng t\u00e1c thu\u1ed1c.<\/p>\n<p>S\u01b0\u0309 du\u0323ng \u0111\u00f4\u0300ng th\u01a1\u0300i l\u00e2u da\u0300i tiotropium bromide v\u01a1\u0301i ca\u0301c thu\u00f4\u0301c kha\u0301ng cholinergic kha\u0301c ch\u01b0a \u0111\u01b0\u01a1\u0323c nghi\u00ean c\u01b0\u0301u. Do \u0111o\u0301, kh\u00f4ng khuy\u00ea\u0301n ca\u0301o du\u0300ng \u0111\u00f4\u0300ng th\u01a1\u0300i l\u00e2u da\u0300i Spiolto Respimat v\u01a1\u0301i ca\u0301c thu\u00f4\u0301c kha\u0301ng cholinergic kha\u0301c.<\/p>\n<p><em>C\u00e1c thu\u1ed1c ta\u0301c du\u0323ng tr\u00ean h\u1ec7 adrenergic<\/em><\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c ta\u0301c du\u0323ng tr\u00ean h\u1ec7 adrenergic c\u00f3 th\u1ec3 la\u0300m t\u0103ng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a Spiolto Respimat.<\/p>\n<p><em>D\u1eabn ch\u1ea5t Xanthine, Steroid ho\u1eb7c thu\u1ed1c l\u1ee3i ti\u1ec3u<\/em><\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c d\u1eabn ch\u1ea5t xanthine, steroid, ho\u1eb7c c\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u kh\u00f4ng gi\u1eef kali c\u00f3 kh\u1ea3 n\u0103ng ch\u1ecbu \u1ea3nh h\u01b0\u1edfng h\u1ea1 kali huy\u1ebft c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn adrenergic.<\/p>\n<p><em>Thu\u1ed1c ch\u1eb9n beta<\/em><\/p>\n<p>C\u00e1c thu\u1ed1c ch\u1eb9n beta-adrenergic c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1eb7c \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng c\u1ee7a olodaterol. C\u00f3 th\u1ec3 c\u00e2n nh\u0103\u0301c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1eb9n beta ch\u1ecdn l\u1ecdc tr\u00ean tim nh\u01b0ng c\u1ea7n th\u1eadn tr\u1ecdng.<\/p>\n<p><em>Thu\u1ed1c \u1ee9c ch\u1ebf enzym MAO, ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng, thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QTc<\/em><\/p>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf enzym monoamin oxidase, c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng ho\u1eb7c c\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QTc kha\u0301c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u1ea3nh h\u01b0\u1edfng c\u1ee7a spiolto respimat tr\u00ean h\u1ec7 tim m\u1ea1ch.<\/p>\n<p><em>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c theo d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/em><\/p>\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u1ee7a olodaterol s\u01b0\u0309 du\u0323ng ketoconazol, m\u00f4\u0323t ch\u1ea5t \u1ee9c ch\u1ebf ma\u0323nh, \u0111\u00f4\u0300ng th\u01a1\u0300i CYP v\u00e0 P-gp, m\u01b0\u0301c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m to\u00e0n th\u00e2n t\u0103ng 1,7 l\u00e2\u0300n. Kh\u00f4ng c\u00f3 nguy c\u01a1 n\u00e0o li\u00ean quan \u0111\u00ea\u0301n \u0111\u1ed9 an to\u00e0n \u0111\u01b0\u1ee3c ghi nh\u1eadn trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng k\u00e9o d\u00e0i \u0111\u1ebfn m\u1ed9t n\u0103m v\u1edbi m\u1ee9c li\u1ec1u olodaterol l\u00ean t\u01a1\u0301i 2 l\u1ea7n li\u1ec1u khuy\u1ebfn c\u00e1o. Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u Spiolto Respimat.<\/p>\n<h3><span style=\"font-weight: 400;\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef mang thai<\/li>\n<\/ul>\n<p>C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a olodaterol cho th\u1ea5y thu\u00f4\u0301c co\u0301 t\u00e1c d\u1ee5ng \u0111i\u1ec3n h\u00ecnh c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta2-adrenergic \u1edf m\u1ee9c li\u1ec1u cao g\u00e2\u0301p nhi\u00ea\u0300u l\u00e2\u0300n li\u00ea\u0300u \u0111i\u00ea\u0300u tri\u0323.<\/p>\n<p>\u0110\u1ec3 \u0111a\u0309m ba\u0309o an toa\u0300n, n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng Spiolto Respimat cho phu\u0323 n\u01b0\u0303 mang thai.<\/p>\n<p>N\u00ean chu\u0301 y\u0301 t\u00e1c d\u1ee5ng \u01b0\u0301c ch\u00ea\u0301 co bo\u0301p c\u01a1 tr\u01a1n t\u01b0\u0309 cung cu\u0309a c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta-adrenergic nh\u01b0 olodaterol &#8211; m\u1ed9t th\u00e0nh ph\u1ea7n c\u1ee7a Spiolto Respimat.<\/p>\n<ul>\n<li>B\u00e0 m\u1eb9 cho con b\u00fa<\/li>\n<\/ul>\n<p>Trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt c\u1ee7a tiotropium v\u00e0 olodaterol, c\u00e1c d\u1eabn ch\u1ea5t v\u00e0\/ho\u1eb7c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a chu\u0301ng \u0111\u1ec1u \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong s\u1eefa c\u1ee7a chu\u1ed9t c\u1ed1ng \u0111ang cho con b\u00fa. Tuy nhi\u00ean, ch\u01b0a bi\u1ebft ch\u0103\u0301c tiotropium v\u00e0\/ho\u1eb7c olodaterol c\u00f3 \u0111\u01b0\u1ee3c ti\u1ebft v\u00e0o s\u1eefa cu\u0309a ng\u01b0\u1eddi \u0111ang cho con bu\u0301 hay kh\u00f4ng.<\/p>\n<p>Do \u0111\u00f3, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Spiolto Respimat tr\u00ean ph\u1ee5 n\u1eef cho con b\u00fa tr\u1eeb khi l\u1ee3i \u00edch cu\u0309a thu\u00f4\u0301c v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1 c\u00f3 th\u1ec3 x\u1ea3y ra \u0111\u1ed1i v\u1edbi tr\u1ebb nh\u0169 nhi.<\/p>\n<ul>\n<li>Kh\u1ea3 n\u0103ng sinh s\u1ea3n<\/li>\n<\/ul>\n<p>Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u00ea\u0300 a\u0309nh h\u01b0\u01a1\u0309ng c\u1ee7a tiotropium, olodaterol ho\u1eb7c ch\u00ea\u0301 ph\u00e2\u0309m k\u1ebft h\u1ee3p hai tha\u0300nh ph\u00e2\u0300n na\u0300y \u0111\u00ea\u0301n kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng \u0111a\u0303 \u0111\u01b0\u01a1\u0323c th\u1ef1c hi\u1ec7n v\u1edbi tiotropium ho\u0103\u0323c olodaterol \u0111\u01a1n \u0111\u00f4\u0323c kh\u00f4ng cho th\u00e2\u0301y b\u1ea5t ky\u0300 ta\u0301c du\u0323ng b\u1ea5t l\u1ee3i n\u00e0o tr\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<h3><span style=\"font-weight: 400;\">\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/span><\/h3>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p>M\u1eb7c d\u00f9 v\u1eady, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o r\u1eb1ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ch\u00f3ng m\u1eb7t v\u00e0 nhi\u0300n m\u01a1\u0300 khi s\u1eed d\u1ee5ng Spiolto Respimat.<\/p>\n<p>Do \u0111\u00f3, c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. N\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 tr\u00ean, n\u00ean tr\u00e1nh c\u00e1c c\u00f4ng vi\u1ec7c nguy hi\u1ec3m nh\u01b0 l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3><span style=\"font-weight: 400;\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<h4>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u<\/h4>\n<p>Li\u1ec1u cao tiotropium c\u00f3 th\u1ec3 g\u00e2y ca\u0301c bi\u00ea\u0309u hi\u1ec7n va\u0300 tri\u1ec7u ch\u1ee9ng kh\u00e1ng cholinergic.<\/p>\n<p>Kh\u00f4ng xu\u00e2\u0301t hi\u1ec7n c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u00ea\u0301n \u0111i\u00ea\u0300u tri\u0323 sau 14 ng\u00e0y d\u00f9ng li\u1ec1u l\u00ean \u0111\u1ebfn 40 \u03bcg tiotropium d\u01b0\u01a1\u0301i da\u0323ng dung di\u0323ch kh\u00ed dung tr\u00ean ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, ngo\u1ea1i tr\u1eeb kh\u00f4 mi\u1ec7ng\/ho\u0323ng, kh\u00f4 ni\u00eam m\u1ea1c mu\u0303i v\u01a1\u0301i ty\u0309 l\u1ec7 ph\u1ee5 thu\u1ed9c li\u1ec1u [10 &#8211; 40 mcg\/ng\u00e0y] v\u00e0 gi\u1ea3m b\u00e0i ti\u1ebft n\u01b0\u1edbc b\u1ecdt ro\u0303 r\u00ea\u0323t b\u0103\u0301t \u0111\u00e2\u0300u t\u1eeb ng\u00e0y th\u1ee9 7 tr\u1edf \u0111i.<\/p>\n<p>Kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd \u0111a\u0301ng k\u00ea\u0309 na\u0300o \u0111\u01b0\u1ee3c ghi nh\u1eadn trong 6 nghi\u00ean c\u1ee9u k\u00e9o d\u00e0i tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n COPD s\u1eed d\u1ee5ng dung d\u1ecbch kh\u00ed dung tiotropium li\u1ec1u 10 mcg\/ng\u00e0y trong 4 &#8211; 48 tu\u1ea7n.<\/p>\n<p>Qu\u00e1 li\u1ec1u olodaterol c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng qu\u00e1 m\u1ee9c, \u0111\u1eb7c tr\u01b0ng c\u1ee7a ch\u00e2\u0301t ch\u1ee7 v\u1eadn beta2-adrenergic nh\u01b0 thi\u1ebfu m\u00e1u c\u01a1 tim, t\u0103ng huy\u1ebft \u00e1p ho\u1eb7c h\u1ea1 huy\u1ebft \u00e1p, nh\u1ecbp tim nhanh, lo\u1ea1n nh\u1ecbp tim, h\u1ed3i h\u1ed9p, ch\u00f3ng m\u1eb7t, c\u0103ng th\u1eb3ng, m\u1ea5t ng\u1ee7, lo l\u1eafng, \u0111au \u0111\u1ea7u, run, kh\u00f4 mi\u1ec7ng, co th\u0103\u0301t c\u01a1, bu\u1ed3n n\u00f4n, m\u1ec7t m\u1ecfi, kh\u00f3 ch\u1ecbu, h\u1ea1 kali huy\u1ebft, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 nhi\u1ec5m acid chuy\u1ec3n h\u00f3a.<\/p>\n<h4>X\u01b0\u0309 tri\u0301 qu\u00e1 li\u1ec1u<\/h4>\n<p>N\u00ean ng\u1eebng s\u1eed d\u1ee5ng Spiolto Respimat. \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng va\u0300 \u0111i\u00ea\u0300u tri\u0323 h\u00f4\u0303 tr\u01a1\u0323.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng n\u00ean nh\u1eadp vi\u1ec7n.<\/p>\n<p>N\u00ean xem x\u00e9t s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1eb9n beta ch\u1ecdn l\u1ecdc tr\u00ean tim, nh\u01b0ng pha\u0309i \u0111\u1eb7c bi\u1ec7t th\u1eadn tr\u1ecdng vi\u0300 d\u00f9ng thu\u1ed1c ch\u1eb9n beta-adrenergic c\u00f3 th\u1ec3 thu\u0301c \u0111\u00e2\u0309y co th\u1eaft ph\u1ebf qu\u1ea3n.<\/p>\n<h3><span style=\"font-weight: 400;\">B\u1ea3o qu\u1ea3n<\/span><\/h3>\n<p>B\u1ea3o qu\u1ea3n rivaroxaban trong h\u1ed9p k\u00edn, \u0111\u1ec3 n\u01a1i tho\u00e1ng m\u00e1t, xa t\u1ea7m v\u1edbi c\u1ee7a tr\u1ebb em, nhi\u1ec7t \u0111\u1ed9 b\u1ea3o qu\u1ea3n &lt; 30 \u2103. Kh\u00f4ng \u0111\u00f4ng l\u1ea1nh<\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg<\/strong>\u00a0c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng nh\u01b0:\u00a0<\/span><\/p>\n<ol>\n<li><a href=\"https:\/\/vnras.com\/drug\/spirivar-respimat\/\">Thu\u1ed1c Spirivar Respimat<\/a> l\u00e0 thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eafc b\u1ec7nh l\u00fd ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh (COPD) v\u1edbi c\u00e1c bi\u1ebfn ch\u1ee9ng nh\u01b0 kh\u00ed ph\u1ebf th\u0169ng hay vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh, th\u00e0nh ph\u1ea7n l\u00e0 Tiotropium ( bromide monohydrate) v\u1edbi h\u00e0m l\u01b0\u1ee3ng 2.5mcg\/nh \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd v\u00e0 s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty Boehringer Ingelheim<\/li>\n<\/ol>\n<h2><span style=\"font-weight: 400;\">T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg?<\/span><\/h2>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 60.308%; text-align: center;\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 39.692%; text-align: center;\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 60.308%;\">Thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tri\u0323 gia\u0303n ph\u00ea\u0301 qua\u0309n duy tri\u0300 \u0111\u00ea\u0309 gia\u0309m ca\u0301c tri\u1ec7u ch\u01b0\u0301ng \u01a1\u0309 b\u1ec7nh nh\u00e2n tr\u01b0\u01a1\u0309ng tha\u0300nh bi\u0323 b\u1ec7nh ph\u00f4\u0309i t\u0103\u0301c nghe\u0303n ma\u0323n ti\u0301nh (COPD).<\/p>\n<p>Tiotropium, m\u1ed9t thu\u1ed1c kh\u00e1ng muscarinic t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i, v\u00e0 olodaterol, m\u1ed9t thu\u1ed1c chu\u0309 v\u1eadn beta2-adrenergic t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i.<\/p>\n<p>S\u1ef1 k\u1ebft h\u1ee3p 2 th\u00e0nh ph\u1ea7n gi\u00fap hi\u1ec7p \u0111\u1ed3ng ta\u0301c du\u0323ng gi\u00e3n ph\u1ebf qu\u1ea3n do ch\u00fang c\u00f3 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng kha\u0301c nhau v\u00e0 vi\u0323 tri\u0301 \u0111\u00edch ta\u0301c du\u0323ng tr\u00ean ph\u1ed5i kh\u00e1c nhau.<\/p>\n<p>Respimat la\u0300 b\u01b0\u01a1\u0301c ti\u00ea\u0301n b\u00f4\u0323 v\u00ea\u0300 c\u00f4ng ngh\u00ea\u0323 du\u0323ng cu\u0323 hi\u0301t v\u01a1\u0301i c\u01a1 ch\u00ea\u0301 \u0111\u00f4\u0323c \u0111a\u0301o s\u01b0\u0309 du\u0323ng n\u0103ng l\u01b0\u01a1\u0323ng \u0111\u01b0\u01a1\u0323c gia\u0309i pho\u0301ng t\u01b0\u0300 s\u01b0\u0301c ne\u0301n cu\u0309a lo\u0300 xo, v\u1edbi thao t\u00e1c \u0111\u01a1n gi\u1ea3n nh\u01b0ng hi\u1ec7u qu\u1ea3 cao<\/p>\n<p>h\u00ea\u0323 th\u00f4\u0301ng vo\u0300i phun \u0111\u00ea\u0309 ta\u0323o tha\u0300nh ha\u0323t v\u01a1\u0301i ki\u0301ch th\u01b0\u01a1\u0301c mi\u0323n, t\u00f4\u0301c \u0111\u00f4\u0323 gia\u0309i pho\u0301ng thu\u00f4\u0301c ch\u00e2\u0323m va\u0300 th\u01a1\u0300i gian di chuy\u1ec3n k\u00e9o d\u00e0i giu\u0301p b\u00ea\u0323nh nh\u00e2n d\u00ea\u0303 da\u0300ng hi\u0301t thu\u00f4\u0301c va\u0300 thu\u00f4\u0301c \u0111\u01b0\u01a1\u0323c ph\u00e2n b\u00f4\u0301 \u01a1\u0309 ph\u00f4\u0309i nhi\u00ea\u0300u h\u01a1n<\/p>\n<p>S\u1ef1 k\u1ebft h\u1ee3p 2 th\u00e0nh ph\u1ea7n c\u00f3 trong thu\u1ed1c cho th\u1ea5y hi\u1ec7u qu\u1ea3, gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 v\u1ec1 s\u1ed1 l\u01b0\u1ee3ng \u0111\u1ee3t tr\u1ea7m tr\u1ecdng v\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh, glucocorticosteroid trong qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u, \u0111i\u1ec1u n\u00e0y c\u0169ng \u0111i k\u00e8m v\u1edbi vi\u1ec7c gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng<\/td>\n<td style=\"width: 39.692%;\">M\u1eb7c d\u00f9 s\u1ef1 k\u1ebft h\u1ee3p Tiotropium v\u00e0 olodaterol c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 \u0111\u1ee3t c\u1ea5p COPD nh\u01b0ng n\u00f3 kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1ec1 m\u1eb7t chi ph\u00ed v\u00e0 c\u1ea7n ph\u1ea3i \u0111\u1ecbnh gi\u00e1 l\u1ea1i.<\/p>\n<p>Thu\u1ed1c ch\u1ec9 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh do c\u00e1c d\u1eef li\u1ec7u cho tr\u1ebb ch\u01b0a c\u00f3 \u0111\u1ee7.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Karl-Otto Steinmetz v\u00e0 c\u1ed9ng s\u1ef1 (Ng\u00e0y \u0111\u0103ng: Th\u00e1ng 7 n\u0103m 2019).<em> Assessment of physical functioning and handling of tiotropium\/olodaterol Respimat\u00ae in patients with COPD in a real-world clinical setting<\/em>. Truy c\u1eadp ng\u00e0y 23 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31308649\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31308649\/<\/a><\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3o Ying Lan v\u00e0 c\u1ed9ng s\u1ef1 (Ng\u00e0y \u0111\u0103ng 7 th\u00e1ng 5 n\u0103m 2020). <em>Cost-Effectiveness Analysis of Fixed-Dose Tiotropium\/Olodaterol versus Tiotropium for COPD Patients in China<\/em>. Truy c\u1eadp ng\u00e0y 23 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37767047\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37767047\/<\/a><\/span><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Spiolto Respimat 2.5mcg\/2.5mcg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2023\/11\/Huong-dan-su-dung-Respiratory-Spiolto-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c x\u1ecbt kh\u00ed dung Spiolto Respimat 2.5mcg\/2.5mcg c\u1ee7a Boehringer Ingelheim c\u00f3 t\u00e1c d\u1ee5ng gi\u00e3n ph\u1ebf qu\u1ea3n cho ng\u01b0\u1eddi COPD<\/p>\n","protected":false},"author":490,"featured_media":58699,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-58697","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/58697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=58697"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/58699"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=58697"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=58697"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=58697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}