{"id":57785,"date":"2023-11-19T12:52:12","date_gmt":"2023-11-19T05:52:12","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=57785"},"modified":"2025-07-24T13:59:32","modified_gmt":"2025-07-24T06:59:32","slug":"thuoc-zytiga-250mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-zytiga-250mg\/","title":{"rendered":"Zytiga 250mg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/thuoc-zytiga-250mg\/\">Zytiga 250mg<\/a> v\u1edbi th\u00e0nh ph\u1ea7n ch\u1ee9a Abirateron acetat; l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t m\u1edbi ch\u1ea9n \u0111o\u00e1n, do Patheon Inc &#8211; Canada s\u1ea3n xu\u1ea5t, s\u1ed1 l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-19678-16, do Johnson &amp; Johnson (Vi\u1ec7t Nam) \u0111\u0103ng k\u00fd.\u00a0<\/b><\/p>\n<h2><span style=\"font-weight: 400;\">Zytiga 250mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"><strong>Thu\u1ed1c<\/strong> <strong>Zytiga 250mg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\">Abirateron acetat: 250mg.<\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n\u00a0<\/span><\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p><span style=\"font-weight: 400;\">S\u0110K: VN-19678-16 .<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd 120 vi\u00ean<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xu\u1ea5t x\u1ee9: Patheon Inc &#8211; Canada<\/span><\/p>\n<p>\u0110\u01a1n v\u1ecb \u0111\u0103ng k\u00fd: ohnson &amp; Johnson (Vi\u1ec7t Nam)<\/p>\n<h2><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zytiga 250mg<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p>Abiraterone \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ch\u1ea5t \u0111\u00f3ng vai tr\u00f2 trung gian trong nhi\u1ec1u qu\u00e1 t\u00ecnh d\u01b0\u1ee3c l\u00fd. Khi v\u00e0o c\u01a1 th\u1ec3, Abiraterone g\u00e2y gi\u1ea3m Testosterone c\u0169ng nh\u01b0 nhi\u1ec1u n\u1ed9i ti\u1ebft t\u1ed1 Androgen. Sau khi s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 th\u1ea5y r\u00f5 s\u1ef1 thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 c\u1ee7a c\u00e1c kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u c\u1ee7a tuy\u1ebfn ti\u1ec1n li\u1ec7t \u1edf b\u00ean trong huy\u1ebft thanh.<\/p>\n<p>Abiraterone l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p kh\u00e1ng androgen m\u1edbi \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 nh\u1eafm v\u00e0o tr\u1ee5c truy\u1ec1n t\u00edn hi\u1ec7u qua trung gian androgen c\u1ee7a tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 t\u1ed5ng h\u1ee3p c\u00e1c s\u1ea3n ph\u1ea9m tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn \u0111\u00f3ng vai tr\u00f2 l\u00e0 ti\u1ec1n ch\u1ea5t t\u1ed5ng h\u1ee3p testosterone v\u00e0 Dihydrotestosterone Abiraterone ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 pregnenolone, \u1ee9c ch\u1ebf enzyme gi\u1edbi h\u1ea1n t\u1ed1c \u0111\u1ed9, cytochrome P450 (CYP17A1), \u1ee9c ch\u1ebf h\u01a1n n\u1eefa qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p androgen.<\/p>\n<h3><span style=\"font-weight: 400;\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<p>H\u1ea5p thu: Gi\u00e1 tr\u1ecb trung b\u00ecnh h\u00ecnh h\u1ecdc (\u00b1 SD) C max l\u00e0 73 (\u00b1 44) ng\/mL v\u00e0 AUC 0-\u221e l\u00e0 373 (\u00b1 249) ng x gi\u1edd\/mL sau khi d\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t 500mg Abiraterone Acetate \u1edf nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh nh\u1ecbn \u0103n qua \u0111\u00eam.<\/p>\n<p>Ph\u00e2n b\u1ed1: Kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n ph\u1ed1i Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh bi\u1ec3u ki\u1ebfn trung b\u00ecnh (\u00b1 SD) l\u00e0 19.669 (\u00b1 13.358) L. Li\u00ean k\u1ebft protein Abiraterone li\u00ean k\u1ebft cao (&gt;99%) v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi, Albumin v\u00e0 glycoprotein axit alpha-1.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: S\u1ef1 chuy\u1ec3n \u0111\u1ed5i Abiraterone Acetate th\u00e0nh Abiraterone, ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n qua trung gian c\u00e1c esterase, m\u1eb7c d\u00f9 c\u00e1c esterase c\u1ee5 th\u1ec3 ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. Trong huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi, hai ch\u1ea5t chuy\u1ec3n h\u00f3a tu\u1ea7n ho\u00e0n ch\u00ednh l\u00e0 Abiraterone sulfate, \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh b\u1edfi CYP3A4 v\u00e0 SULT2A1, v\u00e0 N-oxide Abiraterone sulfate, \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh b\u1edfi SULT2A1. M\u1ed7i ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y chi\u1ebfm kho\u1ea3ng 43% l\u01b0\u1ee3ng ti\u1ebfp x\u00fac v\u1edbi Abiraterone v\u00e0 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/p>\n<p>Th\u1ea3i tr\u1eeb: \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc mCRPC, th\u1eddi gian b\u00e1n h\u1ee7y trung b\u00ecnh (\u00b1 SD) c\u1ee7a Abiraterone trong huy\u1ebft t\u01b0\u01a1ng l\u00e0 12 (\u00b1 5) gi\u1edd. Kho\u1ea3ng 5% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u, 88% ph\u00f3ng x\u1ea1 xu\u1ea5t hi\u1ec7n trong ph\u00e2n.<\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Zytiga 250mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p>Thu\u1ed1c Zytiga 250mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi prednisone hay prednisolone \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t m\u1edbi ch\u1ea9n \u0111o\u00e1n, di c\u0103n, c\u00f3 nguy c\u01a1 cao c\u00f2n nh\u1ea1y c\u1ea3m v\u1edbi n\u1ed9i ti\u1ebft (mHSPC) \u1edf b\u1ec7nh nh\u00e2n nam gi\u1edbi ng\u01b0\u1eddi l\u1edbn trong \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7t ti\u00eau androgen<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t kh\u00e1ng c\u1eaft tinh ho\u00e0n di c\u0103n \u1edf b\u1ec7nh nh\u00e2n nam gi\u1edbi\/ ng\u01b0\u1eddi l\u1edbn m\u00e0 b\u1ec7nh \u0111ang ti\u1ebfn tri\u1ec3n trong ho\u1eb7c sau m\u1ed9t \u0111\u1ee3t h\u00f3a tr\u1ecb c\u00f3 ch\u1ee9a docetaxel<\/p>\n<h2><span style=\"font-weight: 400;\">Li\u1ec1u d\u00f9ng &#8211; c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Zytiga 250mg<\/span><\/h2>\n<h3>C\u00e1ch d\u00f9ng thu\u1ed1c Zytiga 250mg<\/h3>\n<p>S\u1eed d\u1ee5ng \u00edt nh\u1ea5t hai gi\u1edd sau khi \u0103n v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c \u0103n \u00edt nh\u1ea5t m\u1ed9t gi\u1edd sau khi u\u1ed1ng thu\u1ed1c.<\/p>\n<p>Thu\u1ed1c ph\u1ea3i \u0111\u01b0\u1ee3c u\u1ed1ng nguy\u00ean vi\u00ean v\u1edbi n\u01b0\u1edbc.<\/p>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Zytiga 250mg<\/h3>\n<p>Li\u1ec1u d\u00f9ng duy nh\u1ea5t m\u1ed7i ng\u00e0y \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 4 vi\u00ean m\u1ed7i ng\u00e0y<\/p>\n<h2><span style=\"font-weight: 400;\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Zytiga 250mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p>Ng\u01b0\u1eddi qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi th\u00e0nh ph\u1ea7n c\u1ee7a Zytiga<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang mang thai, c\u00f3 kh\u1ea3 n\u0103ng \u0111ang mang thai v\u00e0 \u0111ang cho con b\u00fa<\/p>\n<p>Ng\u01b0\u1eddi b\u1ecb suy gan n\u1eb7ng<\/p>\n<h2><span style=\"font-weight: 400;\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Zytiga 250mg<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u1eadn tr\u1ecdng<\/span><\/h3>\n<p>Th\u1eadt th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ecb T\u0103ng huy\u1ebft \u00e1p, h\u1ea1 kali m\u00e1u, gi\u1eef n\u01b0\u1edbc v\u00e0 suy tim do th\u1eeba mineralocorticoid<\/p>\n<p>B\u1ec7nh nh\u00e2n suy tim, \u0111au th\u1eaft ng\u1ef1c n\u1eb7ng ho\u1eb7c kh\u00f4ng \u1ed5n \u0111\u1ecbnh, g\u1ea7n \u0111\u00e2y b\u1ecb nh\u1ed3i m\u00e1u c\u01a1 tim ho\u1eb7c lo\u1ea1n nh\u1ecbp th\u1ea5t, suy th\u1eadn n\u1eb7ng, c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim m\u1ea1ch, \u0111ang d\u00f9ng glycosid tr\u1ee3 tim ho\u1eb7c thu\u1ed1c \u0111\u00e3 bi\u1ebft c\u00f3 li\u00ean quan b\u1ec7nh c\u01a1\/ti\u00eau c\u01a1 v\u00e2n.<\/p>\n<p>\u0110\u1ecbnh l\u01b0\u1ee3ng transaminase huy\u1ebft thanh tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, m\u1ed7i 2 tu\u1ea7n trong 3 th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 m\u1ed7i th\u00e1ng sau \u0111\u00f3.<\/p>\n<p>Theo d\u00f5i ch\u1ec9 s\u1ed1 HA, kali huy\u1ebft thanh v\u00e0 t\u00ecnh tr\u1ea1ng gi\u1eef n\u01b0\u1edbc \u0111\u1ecbnh k\u1ef3 m\u1ed7i th\u00e1ng (ho\u1eb7c m\u1ed7i 2 tu\u1ea7n trong 3 th\u00e1ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u ti\u00ean v\u00e0 sau \u0111\u00f3 h\u00e0ng th\u00e1ng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao suy tim sung huy\u1ebft).<\/p>\n<p>Kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu Lapp lactase, k\u00e9m h\u1ea5p th\u1ee5 glucose-galactose: kh\u00f4ng n\u00ean d\u00f9ng.<\/p>\n<p>C\u00e2n nh\u1eafc s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n \u0103n ki\u00eang natri (c\u00f3 27.2mg natri\/li\u1ec1u 4 vi\u00ean), ng\u1eebng \u0111i\u1ec1u tr\u1ecb n\u1ebfu c\u00f3 suy tim \u0111\u00e1ng k\u1ec3.<\/p>\n<h3><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 r\u1ea5t th\u01b0\u1eddng g\u1eb7p: H\u1ea1 kali m\u00e1u, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, ti\u00eau ch\u1ea3y, t\u0103ng HA, ph\u00f9 n\u1ec1 ngo\u1ea1i bi\u00ean.<\/p>\n<p>T\u00e1c d\u1ee5ng th\u01b0\u1eddng g\u1eb7p: Nhi\u1ec5m tr\u00f9ng huy\u1ebft, suy tim, \u0111au th\u1eaft v\u00f9ng ng\u1ef1c, rung nh\u0129, tim \u0111\u1eadp nhanh, kh\u00f3 ti\u00eau, ti\u1ec3u m\u00e1u, t\u0103ng glycerid m\u00e1u<\/p>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1 hi\u1ebfm\/ \u00edt khi g\u1eb7p: Suy tuy\u00ea\u0301n th\u01b0\u01a1\u0323ng th\u00e2\u0323n; c\u00e1c lo\u1ea1n nh\u1ecbp tim kh\u00e1c; b\u1ec7nh c\u01a1, ti\u00eau c\u01a1 v\u00e2n<\/p>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 r\u1ea5t hi\u1ebfm g\u1eb7p: b\u00f9ng ph\u00e1t vi\u00eam gan, vi\u00eam ph\u1ebf nang d\u1ecb \u1ee9ng, suy gan c\u1ea5p, nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n<h3><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n<p>Ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng CYP3A4 m\u1ea1nh: Khi\u1ebfn Abiraterone gi\u1ea3m n\u1ed3ng \u0111\u1ed9 huy\u1ebft thanh<\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP2D6: B\u1ecb t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh<\/p>\n<p>C\u00e1c thu\u1ed1c l\u00e0m t\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i dodanjj QT<\/p>\n<ul>\n<li>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m IA<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n<\/li>\n<li>Thu\u1ed1c gi\u1ea3m \u0111au g\u00e2y nghi\u1ec7n Methadone<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m III<\/li>\n<li>Kh\u00e1ng sinh moxifloxacin<\/li>\n<\/ul>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef Kali Spironolactone: B\u1ecb gi\u1ea3m t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb<\/p>\n<p>B\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o: C\u00f3 th\u1ec3 khi\u1ebfn thu\u1ed1c t\u0103ng n\u1ed3ng \u0111\u1ed9<\/p>\n<p>St. John&#8217;s wort: Khi\u1ebfn thu\u1ed1c gi\u1ea3m n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh<\/p>\n<h3><span style=\"font-weight: 400;\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/p>\n<p>B\u00e0 m\u1eb9 \u0111ang cho con b\u00fa: Kh\u00f4ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c abiraterone acetate hay ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a thu\u1ed1c c\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa ng\u01b0\u1eddi hay kh\u00f4ng. Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c \u1edf ng\u01b0\u1eddi \u0111ang cho con b\u00fa.<\/p>\n<h3><span style=\"font-weight: 400;\">\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/span><\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a Zytiga tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Nhi\u1ec1u kh\u1ea3 n\u0103ng ZYTIGA \u00edt \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c kh\u1ea3 n\u0103ng n\u00e0y.<\/p>\n<h3><span style=\"font-weight: 400;\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1c b\u00e1o c\u00e1o v\u1ec1 t\u00ecnh tr\u1ea1ng d\u00f9ng qu\u00e1 li\u1ec1u <strong>Zytiga janssen<\/strong> trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng.<\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, n\u00ean ng\u01b0ng ngay Zytiga v\u00e0 tri\u1ec3n khai c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e2ng \u0111\u1ee1 bao g\u1ed3m ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim v\u00e0 c\u0169ng c\u1ea7n \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng gan.<\/p>\n<h3><span style=\"font-weight: 400;\">B\u1ea3o qu\u1ea3n<\/span><\/h3>\n<p>B\u1ea3o qu\u1ea3n d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Zytiga (Abiraterone) 250mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Thu\u1ed1c Zytiga 250mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Zytiga Abiraterone 250mg<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c nh\u01b0:\u00a0<\/span><\/p>\n<ol>\n<li><a href=\"https:\/\/vnras.com\/drug\/casodex\/\">Thu\u1ed1c Casodex<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty AstraZeneca GmbH \u2013 \u0110\u1ee8C , c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-8052-04, \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd b\u1edfi c\u00f4ng ty AstraZeneca Singapore Pte., Ltd. Thu\u1ed1c Casodex l\u00e0 thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch v\u00e0 c\u00f3 ng\u0103n ng\u1eeba ung th\u01b0 c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Bicalutamide v\u1edbi h\u00e0m l\u01b0\u1ee3ng 50mg, h\u1ed9p 2 v\u1ec9 x 14 vi\u00ean c\u00f3 gi\u00e1 1400000.<\/li>\n<li><\/li>\n<\/ol>\n<h2><span style=\"font-weight: 400;\">T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Zytiga 250mg?<\/span><\/h2>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 54.2394%; text-align: center;\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 45.7606%; text-align: center;\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 54.2394%;\">Thu\u1ed1c Zytiga c\u00f3 ch\u1ee9a Abiraterone, l\u00e0 1 ch\u1ea5t \u1ee9c ch\u1ebf CYP17, ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p androgen \u1edf nhi\u1ec1u lo\u1ea1i m\u00f4. K\u1ebft h\u1ee3p v\u1edbi prednisone, n\u00f3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u tay cho b\u1ec7nh ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t kh\u00e1ng thi\u1ebfn di c\u0103n<\/p>\n<p>Abiraterone nh\u00ecn chung m\u1ed9t lo\u1ea1i thu\u1ed1c u\u1ed1ng, dung n\u1ea1p t\u1ed1t, nh\u1eafm \u0111\u1ebfn m\u00f4 h\u00ecnh m\u1edbi \u0111\u01b0\u1ee3c l\u00e0m s\u00e1ng t\u1ecf v\u1ec1 vi\u1ec7c ti\u1ebfp t\u1ee5c k\u00edch ho\u1ea1t AR trong ung th\u01b0 ti\u1ec1n li\u1ec7t tuy\u1ebfn, \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y<\/p>\n<p>Vi\u1ec7c b\u1ed5 sung abiraterone acetate v\u00e0 Prednisone v\u00e0o li\u1ec7u ph\u00e1p c\u1eaft b\u1ecf androgen l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t chung v\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t kh\u00f4ng ti\u1ebfn tri\u1ec3n tr\u00ean phim X quang \u1edf nam gi\u1edbi m\u1eafc ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t nh\u1ea1y c\u1ea3m v\u1edbi thi\u1ebfn, di c\u0103n, m\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n<\/p>\n<p>D\u1ea1ng vi\u00ean n\u00e9n nh\u1ecf g\u1ecdn, d\u1ec5 d\u00e0ng s\u1eed d\u1ee5ng, h\u1ed9p 120 gi\u00fap ti\u1ebft ki\u1ec7m chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi b\u1ec7nh, gi\u00e1 th\u00e0nh ph\u1ea3i ch\u0103ng so v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 kh\u00e1c.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u0169ng cho th\u1ea5y S\u1ef1 \u1ee9c ch\u1ebf sinh t\u1ed5ng h\u1ee3p androgen c\u1ee7a abiraterone acetate \u0111\u00e3 k\u00e9o d\u00e0i th\u1eddi gian s\u1ed1ng s\u00f3t chung \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t kh\u00e1ng thi\u1ebfn di c\u0103n \u0111\u00e3 \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3<\/p>\n<p>S\u1ea3n xu\u1ea5t v\u00e0 nghi\u00ean c\u1ee9u b\u1edfi h\u00e3ng d\u01b0\u1ee3c Janssen &#8211; Patheon Inc, 1 trong nh\u1eefng th\u01b0\u01a1ng hi\u1ec7u to\u00e0n c\u1ea7u \u0111\u1ecbnh h\u01b0\u1edbng \u0111\u1ed5i m\u1edbi khoa h\u1ecdc s\u1ed1 1 tr\u00ean th\u1ebf gi\u1edbi<\/td>\n<td style=\"width: 45.7606%;\">Thu\u1ed1c c\u00f3 nhi\u1ec1u t\u01b0\u01a1ng t\u00e1c v\u00e0 l\u01b0u \u00fd khi s\u1eed d\u1ee5ng, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n, ch\u1ec9 \u0111\u1ecbnh v\u00e0 theo d\u00f5i b\u1edfi c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng c\u00f3 chuy\u00ean m\u00f4n.<\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p bao g\u1ed3m ti\u00eau ch\u1ea3y, ph\u00f9 n\u1ec1, h\u1ea1 kali m\u00e1u, t\u0103ng huy\u1ebft \u00e1p v\u00e0 b\u1ea5t th\u01b0\u1eddng v\u1ec1 x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan. C\u00e1c tr\u01b0\u1eddng h\u1ee3p ti\u00eau c\u01a1 v\u00e2n ph\u00e1t tri\u1ec3n li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng abiraterone \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. Sau khi ng\u1eebng s\u1eed d\u1ee5ng abiraterone, n\u1ed3ng \u0111\u1ed9 creatine kinase gi\u1ea3m d\u1ea7n trong su\u1ed1t th\u1eddi gian n\u1eb1m vi\u1ec7n.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Donald C Moore, Andrew Moore (Ng\u00e0y \u0111\u0103ng:Ng\u00e0y Th\u00e1ng 3 n\u0103m 2017). <em>Abiraterone-induced rhabdomyolysis: A case report<\/em>,. Truy c\u1eadp ng\u00e0y 19 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23199349\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/23199349\/<\/a><\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Charles J Ryan v\u00e0 Michael L Cheng (Ng\u00e0y \u0111\u0103ng: Ng\u00e0y 30 th\u00e1ng 11 n\u0103m 2013). <em>Abiraterone acetate for the treatment of prostate cance<\/em>. Truy c\u1eadp ng\u00e0y 19 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23199349\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/23199349\/<\/a><\/span><\/li>\n<li><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Johann S. de Bono v\u00e0 c\u1ed9ng s\u1ef1 (Ng\u00e0y \u0111\u0103ng: Ng\u00e0y 15 th\u00e1ng 10 n\u0103m 2012). <em>Abiraterone and Increased Survival in Metastatic Prostate Cancer<\/em>. Truy c\u1eadp ng\u00e0y 19 th\u00e1ng 11 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3471149\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3471149\/<\/a><\/span><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Zytiga 250mg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2023\/11\/Huong-dan-su-dung-thuoc-zytiga-250mg-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ti\u1ec1n li\u1ec7t tuy\u1ebfn Zytiga 250mg h\u1ed9p 120 vi\u00ean ch\u1ee9a Abiraterone acetate xu\u1ea5t x\u1ee9 t\u1eeb Canada<\/p>\n","protected":false},"author":490,"featured_media":112202,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-57785","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/57785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=57785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/112202"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=57785"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=57785"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=57785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}