{"id":53318,"date":"2023-10-30T16:21:14","date_gmt":"2023-10-30T09:21:14","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=53318"},"modified":"2025-07-24T13:59:51","modified_gmt":"2025-07-24T06:59:51","slug":"agilecox-200","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/agilecox-200\/","title":{"rendered":"Agilecox 200"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/agilecox-200\/\">Agilecox 200<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Agimexpharm, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-25523-16<\/strong><\/p>\n<h2>Agilecox 200 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Agilecox 200<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: <strong>Celecoxib 200mg<\/strong>.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u1ee9ng.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-25523-16.<br \/>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 10 vi\u00ean.<br \/>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n<h2>Thu\u1ed1c Agilecox 200 c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Celecoxib thu\u1ed9c nh\u00f3m thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid, c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t, ch\u1ed1ng vi\u00eam.<\/p>\n<p>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a celecoxib th\u00f4ng qua \u1ee9c ch\u1ebf isoenzym cyclooxygenase-2 (COX \u2013 2), t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p prostaglandin.<\/p>\n<p>Celecoxib kh\u00f4ng \u1ee9c ch\u1ebf COX \u2013 1 n\u00ean \u00edt c\u00f3 nguy c\u01a1 g\u00e2y c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5, nh\u01b0ng c\u00f3 th\u1ec3 g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean th\u1eadn.<\/p>\n<h3>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu<\/li>\n<\/ul>\n<p>Celecoxib h\u1ea5p thu nhanh ch\u00f3ng qua \u0111\u01b0\u1eddng ti\u00eau ho\u00e1. So v\u1edbi u\u1ed1ng l\u00fac \u0111\u00f3i, u\u1ed1ng celecoxib trong b\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o l\u00e0m ch\u1eadm th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 l\u00e0m t\u0103ng AUC 10 \u2013 20%. C\u00f3 th\u1ec3 d\u00f9ng celecoxib c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<p>3 gi\u1edd sau khi u\u1ed1ng m\u1ed9t li\u1ec1u duy nh\u1ea5t 200 mg l\u00fac \u0111\u00f3i, thu\u1ed1c \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng. N\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh duy tr\u00ec trong v\u00f2ng 5 ng\u00e0y.<\/p>\n<ul>\n<li>Ph\u00e2n b\u1ed1<\/li>\n<\/ul>\n<p>Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 7,14 l\u00edt\/kg \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>Thu\u1ed1c ph\u00e2n b\u1ed1 r\u1ed9ng v\u00e0o m\u00f4. Celecoxib g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 97%.<\/p>\n<ul>\n<li>Chuy\u1ec3n h\u00f3a, th\u1ea3i tr\u1eeb<\/li>\n<\/ul>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng sau khi u\u1ed1ng l\u00e0 11 gi\u1edd v\u00e0 k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi suy th\u1eadn ho\u1eb7c suy gan. H\u1ec7 s\u1ed1 thanh th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng x\u1ea5p x\u1ec9 500 ml\/ph\u00fat. Celecoxib \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 th\u00e0nh c\u00e1c ch\u1ea5t kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh b\u1edfi isoenzym CYP450 2C9 trong gan.<\/p>\n<p>Celecoxib th\u1ea3i tr\u1eeb trong n\u01b0\u1edbc ti\u1ec3u kho\u1ea3ng 27% v\u00e0 trong ph\u00e2n 57%, &lt; 3% li\u1ec1u \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng thay \u0111\u1ed5i.<\/p>\n<h2>Thu\u1ed1c Agilecox 200 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Celecoxib d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn \u0111\u1ec3 gi\u1ea3m tri\u1ec7u ch\u1ee9ng trong: vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam x\u01b0\u01a1ng kh\u1edbp v\u00e0 vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp.<\/p>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Agilecox 200<\/h2>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p>Thu\u1ed1c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p>Li\u1ec1u 1 vi\u00ean\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y, kh\u00f4ng c\u1ea7n u\u1ed1ng c\u00f9ng b\u1eefa \u0103n. Li\u1ec1u cao 2 vi\u00ean \/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y ph\u1ea3i u\u1ed1ng v\u00e0o b\u1eefa \u0103n.<\/p>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<ul>\n<li>Vi\u00eam x\u01b0\u01a1ng kh\u1edbp v\u00e0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: li\u1ec1u duy nh\u1ea5t 1 vi\u00ean\/ng\u00e0y, n\u1ebfu ch\u01b0a c\u00f3 t\u00e1c d\u1ee5ng d\u00f9ng 1 vi\u00ean x 2 l\u1ea7n\/ng\u00e0y. Sau 2 tu\u1ea7n n\u1ebfu kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 c\u1ea7n xem x\u00e9t thay \u0111\u1ed5i \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp: li\u1ec1u khuy\u1ebfn c\u00e1o duy nh\u1ea5t 1 vi\u00ean\/ng\u00e0y, n\u1ebfu ch\u01b0a c\u00f3 t\u00e1c d\u1ee5ng d\u00f9ng 2 vi\u00ean, m\u1ed9t l\u1ea7n\/ng\u00e0y ho\u1eb7c 1 vi\u00ean x 2 l\u1ea7n\/ng\u00e0y. Sau 2 tu\u1ea7n n\u1ebfu kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 c\u1ea7n xem x\u00e9t thay \u0111\u1ed5i \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<p>T\u1ed1i \u0111a 2 vi\u00ean\/ng\u00e0y.<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: D\u00f9ng nh\u01b0 tr\u01b0\u1eddng h\u1ee3p vi\u00eam x\u01b0\u01a1ng kh\u1edbp v\u00e0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p. Th\u1eadn tr\u1ecdng khi b\u1ec7nh nh\u00e2n c\u00f3 c\u00e2n n\u1eb7ng d\u01b0\u1edbi 50kg.<\/li>\n<li>Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Celecoxib cho tr\u1ebb em.<\/li>\n<li>Ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a k\u00e9m qua CYP2C9: d\u00f9ng li\u1ec1u b\u1eb1ng \u00bd li\u1ec1u khuy\u1ebfn c\u00e1o th\u1ea5p nh\u1ea5t.<\/li>\n<li>Suy gan: B\u1ec7nh nh\u00e2n x\u01a1 gan d\u00f9ng \u00bd li\u1ec1u khuy\u1ebfn c\u00e1o v\u1edbi albumin huy\u1ebft thanh 25 \u2013 35 g\/l.<\/li>\n<li>Th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Agilecox 200 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c ho\u1eb7c v\u1edbi celecoxib ho\u1eb7c sulfonamid.<\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y\/xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a.<\/p>\n<p>M\u00e0y \u0111ay, hen ho\u1eb7c c\u00e1c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng kh\u00e1c sau khi u\u1ed1ng aspirin ho\u1eb7c c\u00e1c NSAIDs kh\u00e1c bao g\u1ed3m thu\u1ed1c \u1ee9c ch\u1ebf COX-2.<\/p>\n<p>Ph\u1ee5 n\u1eef trong thai k\u1ef3 v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng sinh \u0111\u1ebb, tr\u1eeb khi s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<p>Ch\u1ee9c n\u0103ng gan r\u1ed1i lo\u1ea1n n\u1eb7ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 30 ml\/ph\u00fat.<\/p>\n<p>Vi\u00eam ru\u1ed9t.<\/p>\n<p>Suy tim sung huy\u1ebft.<\/p>\n<p>B\u1ec7nh \u0111\u1ed9ng m\u1ea1ch ngo\u1ea1i bi\u00ean, b\u1ec7nh tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0\/ho\u1eb7c b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Agilecox 200<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>C\u00e1c t\u00e1c \u0111\u1ed9ng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/li>\n<\/ul>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng celecoxib \u0111\u00e3 x\u1ea3y ra c\u00e1c bi\u1ebfn ch\u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean v\u00e0 d\u01b0\u1edbi (lo\u00e9t, th\u1ee7ng ho\u1eb7c ch\u1ea3y m\u00e1u) c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong. Th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao: ng\u01b0\u1eddi cao tu\u1ed5i, c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, d\u00f9ng \u0111\u1ed3ng th\u1eddi b\u1ea5t k\u1ef3 NSAID kh\u00e1c\/ acid acetylsalicylic\/ glucocorticoid, s\u1eed d\u1ee5ng r\u01b0\u1ee3u.<\/p>\n<p>Kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi NSAID kh\u00e1c kh\u00f4ng ph\u1ea3i aspirin v\u1edbi celecoxib.<\/p>\n<ul>\n<li>Nguy c\u01a1 huy\u1ebft kh\u1ed1i tim m\u1ea1ch<\/li>\n<\/ul>\n<p>D\u00f9ng celecoxib c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 huy\u1ebft kh\u1ed1i tim m\u1ea1ch nh\u01b0: \u0111\u1ed9t qu\u1ef5, nh\u1ed3i m\u00e1u c\u01a1 tim, c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong, nh\u1ea5t l\u00e0 khi d\u00f9ng li\u1ec1u cao.<\/p>\n<p>C\u1ea7n \u0111\u00e1nh gi\u00e1 \u0111\u1ecbnh k\u1ef3, c\u1ea3nh b\u00e1o cho b\u1ec7nh nh\u00e2n bi\u1ebft, s\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3 \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 n\u00e0y.<\/p>\n<ul>\n<li>\u1ee8 d\u1ecbch v\u00e0 ph\u00f9<\/li>\n<\/ul>\n<p>D\u00f9ng celecoxib c\u00f3 th\u1ec3 g\u00e2y \u1ee9 d\u1ecbch v\u00e0 ph\u00f9, th\u1eadn tr\u1ecdng khi d\u00f9ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1ea5t tr\u00e1i, suy tim ho\u1eb7c t\u0103ng huy\u1ebft \u00e1p, d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u ho\u1eb7c c\u00f3 nguy c\u01a1 gi\u1ea3m th\u1ec3 t\u00edch m\u00e1u.<\/p>\n<ul>\n<li>T\u0103ng huy\u1ebft \u00e1p<\/li>\n<\/ul>\n<p>D\u00f9ng celecoxib c\u00f3 th\u1ec3 g\u00e2y t\u0103ng huy\u1ebft \u00e1p, t\u0103ng t\u1ef7 l\u1ec7 m\u1eafc c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch, v\u00ec v\u1eady c\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p th\u01b0\u1eddng xuy\u00ean.<\/p>\n<ul>\n<li>C\u00e1c t\u00e1c \u0111\u1ed9ng tr\u00ean gan v\u00e0 th\u1eadn<\/li>\n<\/ul>\n<p>Celecoxib c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c cho th\u1eadn, suy gi\u1ea3m ch\u1ee9c n\u0103ng gan. Ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi celecoxib n\u1ebfu c\u00f3 suy gi\u1ea3m b\u1ea5t k\u1ef3 ch\u1ee9c n\u0103ng h\u1ec7 c\u01a1 quan n\u00e0o.<\/p>\n<ul>\n<li>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn tr\u00ean da v\u00e0 to\u00e0n th\u00e2n<\/li>\n<\/ul>\n<p>C\u00f3 th\u1ec3 x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng tr\u00ean da, d\u1eabn \u0111\u1ebfn t\u1eed vong. Ngay khi xu\u1ea5t hi\u1ec7n t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c, m\u1ea9n \u0111\u1ecf da ho\u1eb7c b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u qu\u00e1 m\u1eabn n\u00e0o c\u1ea7n ng\u01b0ng d\u00f9ng celecoxib.<br \/>\nCelecoxib c\u00f3 th\u1ec3 l\u00e0m m\u1edd \u0111i d\u1ea5u hi\u1ec7u c\u1ee7a s\u1ed1t v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u vi\u00eam kh\u00e1c.<\/p>\n<h3>Agilecox 200 t\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t th\u01b0\u1eddng g\u1eb7p:<\/p>\n<p>R\u1ed1i lo\u1ea1n m\u1ea1ch m\u00e1u: T\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p:<\/p>\n<ul>\n<li>Nhi\u1ec5m tr\u00f9ng v\u00e0 nhi\u1ec5m k\u00fd sinh tr\u00f9ng: Vi\u00eam xoang, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, vi\u00eam h\u1ecdng, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean.<\/li>\n<li>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, \u0111\u1ea7y h\u01a1i, n\u00f4n, kh\u00f3 ti\u00eau, kh\u00f3 nu\u1ed1t.<\/li>\n<li>R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, ng\u1ef1c v\u00e0 trung th\u1ea5t: Vi\u00eam m\u0169i, kh\u00f3 th\u1edf, ho.<\/li>\n<li>R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n: M\u1ea5t ng\u1ee7.<\/li>\n<li>R\u1ed1i lo\u1ea1n th\u1ea7n kinh: Ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, t\u0103ng tr\u01b0\u01a1ng l\u1ef1c c\u01a1.<\/li>\n<li>R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da: Ng\u1ee9a, ph\u00e1t ban.<\/li>\n<li>R\u1ed1i lo\u1ea1n tim m\u1ea1ch: Nh\u1ed3i m\u00e1u c\u01a1 tim.<\/li>\n<li>R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch: Qu\u00e1 m\u1eabn.<\/li>\n<li>R\u1ed1i lo\u1ea1n c\u01a1 x\u01b0\u01a1ng v\u00e0 m\u00f4 li\u00ean k\u1ebft: \u0110au kh\u1edbp.<\/li>\n<li>R\u1ed1i lo\u1ea1n to\u00e0n th\u00e2n v\u00e0 t\u1ea1i ch\u1ed7: tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam, gi\u1eef n\u01b0\u1edbc.<\/li>\n<li>T\u1ed5n th\u01b0\u01a1ng.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u: Theo d\u00f5i ch\u1eb7t ch\u1ebd th\u1eddi gian prothrombin, \u0111\u1eb7c bi\u1ec7t trong nh\u1eefng ng\u00e0y \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c thay \u0111\u1ed5i li\u1ec1u v\u00ec c\u00f3 nguy c\u01a1 cao b\u1ecb bi\u1ebfn ch\u1ee9ng ch\u1ea3y m\u00e1u khi d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi Celecoxib.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p: t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u00f3 th\u1ec3 gi\u1ea3m khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Celecoxib.<\/p>\n<p>Ciclosporin v\u00e0 tacrolimus: t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9c cho th\u1eadn c\u1ee7a ciclosporin ho\u1eb7c tacrolimus c\u00f3 th\u1ec3 t\u0103ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Celecoxib.<\/p>\n<p>Acid acetylsalicylic: d\u00f9ng \u0111\u1ed3ng th\u1eddi acid acetylsalicylic li\u1ec1u th\u1ea5p v\u1edbi celecoxib l\u00e0m t\u0103ng nguy c\u01a1 bi\u1ebfn ch\u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<p>C\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP2D6: n\u1ed3ng \u0111\u1ed9 c\u00e1c thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 t\u0103ng l\u00ean khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi celecoxib.<\/p>\n<p>Celecoxib c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP2C19 l\u00e0 citalopram, diazepam v\u00e0 imipramin.<\/p>\n<p>Methotrexat: c\u00e2n nh\u1eafc \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed9c t\u00ednh li\u00ean quan khi k\u1ebft h\u1ee3p v\u1edbi celecoxib.<\/p>\n<p>Lithi: theo d\u00f5i ch\u1eb7t ch\u1ebd khi d\u00f9ng celecoxib ho\u1eb7c ng\u1eebng d\u00f9ng celecoxib khi b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng lithi.<\/p>\n<p>Nh\u1eefng ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a k\u00e9m qua CYP2C9 c\u00f3 th\u1ec3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u0103ng ti\u1ebfp x\u00fac v\u1edbi celecoxib.<\/p>\n<p>Ch\u1ea5t \u1ee9c ch\u1ebf CYP2C9 v\u00e0 ch\u1ea5t c\u1ea3m \u1ee9ng: s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 celecoxib trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef mang thai<\/li>\n<\/ul>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng celecoxib trong thai k\u1ef3 v\u00ec \u0111\u00e3 c\u00f3 nh\u1eefng nghi\u00ean c\u1ee9u v\u1ec1 \u0111\u1ed9c t\u00ednh tr\u00ean sinh s\u1ea3n \u1edf \u0111\u1ed9ng v\u1eadt.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 d\u1ef1 mang thai ho\u1eb7c \u0111ang s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai c\u1ea7n h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u1ef9 tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c n\u00e0y.<\/p>\n<ul>\n<li>Ph\u1ee5 n\u1eef cho con b\u00fa<\/li>\n<\/ul>\n<p>Kh\u00f4ng n\u00ean cho tr\u1ebb b\u00fa m\u1eb9 n\u1ebfu ng\u01b0\u1eddi m\u1eb9 \u0111ang d\u00f9ng celecoxib.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng: ng\u1ee7 l\u1ecbm, n\u00f4n, bu\u1ed3n n\u00f4n, ng\u1ee7 l\u01a1 m\u01a1 v\u00e0 \u0111au v\u00f9ng th\u01b0\u1ee3ng v\u1ecb, ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau ho\u00e1. Hi\u1ebfm h\u01a1n l\u00e0 suy th\u1eadn c\u1ea5p, t\u0103ng huy\u1ebft \u00e1p, \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p v\u00e0 h\u00f4n m\u00ea.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb: \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng v\u00e0 d\u00f9ng bi\u1ec7n ph\u00e1p n\u00e2ng \u0111\u1ee1. Trong 4 gi\u1edd \u0111\u1ea7u sau d\u00f9ng qu\u00e1 li\u1ec1u, g\u00e2y n\u00f4n ho\u1eb7c d\u00f9ng than ho\u1ea1t c\u00f3 th\u1ec3 c\u00f3 \u00edch.<\/p>\n<h3>T\u00e1c \u0111\u1ed9ng tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t v\u00ec v\u1eady c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi \u0111ang l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h2>Thu\u1ed1c Agilecox 200 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Agilecox 200<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/celebrex\/\">Celebrex<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Pfizer Limited, ch\u1ee9a Celecoxib h\u00e0m l\u01b0\u1ee3ng 200mg. Thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb vi\u00eam x\u01b0\u01a1ng kh\u1edbp n\u0103\u0323ng va\u0300 v\u01b0\u0300a, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p v\u00e0 vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp. Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean ne\u0301n nang c\u1ee9ng, trong vi\u00eam c\u00f4\u0323t s\u00f4\u0301ng co\u0301 di\u0301nh kh\u01a1\u0301p b\u1ea1n c\u00f3 th\u1ec3 u\u1ed1ng 2 vi\u00ean \/ng\u00e0y. Thu\u1ed1c c\u00f3 gi\u00e1 355.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 3 v\u1ec9 x 10 vi\u00ean.<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/cofidec-200mg\/\">Cofidec 200mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Lek Pharmaceutical D.D \u2013 Slovenia ch\u1ee9a Celecoxib v\u1edbi h\u00e0m l\u01b0\u1ee3ng 200mg d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ee7a c\u00e1c b\u1ec7nh l\u00fd x\u01b0\u01a1ng kh\u1edbp nh\u01b0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam x\u01b0\u01a1ng m\u1ea1n t\u00ednh. Thu\u1ed1c c\u00f3 d\u1ea1ng vi\u00ean n\u00e9n nang c\u1ee9ng v\u00e0 c\u00f3 gi\u00e1 kho\u1ea3ng 45.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 2 v\u1ec9 x 10 vi\u00ean.<\/p>\n<h2>T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Agilecox 200?<\/h2>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 52.99%;text-align: center\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 47.01%;text-align: center\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 52.99%\">FDA khuy\u1ebfn c\u00e1o celecoxib l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au h\u00e0ng \u0111\u1ea7u cho b\u1ec7nh nh\u00e2n vi\u00eam x\u01b0\u01a1ng kh\u1edbp v\u00e0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p.<\/td>\n<td style=\"width: 47.01%\">Agilecox 200 kh\u00f4ng an to\u00e0n khi s\u1eed d\u1ee5ng trong thai k\u1ef3 v\u00e0 giai \u0111o\u1ea1n cho con b\u00fa.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 52.99%\">Coxib \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam\/gi\u1ea3m \u0111au t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c NSAID kh\u00f4ng ch\u1ecdn l\u1ecdc, nh\u01b0ng kh\u00f4ng c\u00f3 \u0111\u1ed9c t\u00ednh \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean.<\/td>\n<td style=\"width: 47.01%\">Agilecox 200 c\u00f3 th\u1ec3 x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c v\u1edbi kh\u00e1 nhi\u1ec1u thu\u1ed1c.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 52.99%\">Ngo\u00e0i ra, Celecoxib c\u0169ng \u0111\u01b0\u1ee3c FDA ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 ki\u1ec3m so\u00e1t c\u01a1n \u0111au c\u1ea5p t\u00ednh \u1edf ph\u1ee5 n\u1eef tr\u01b0\u1edfng th\u00e0nh v\u00e0 \u0111au b\u1ee5ng kinh nguy\u00ean ph\u00e1t.<\/td>\n<td style=\"width: 47.01%\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 52.99%\">Agilecox 200 l\u00e0 s\u1ea3n ph\u1ea9m c\u1ee7a C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Agimexpharm lu\u00f4n \u0111\u1ec1 cao gi\u00e1 tr\u1ecb th\u1eadt, mang \u0111\u1ebfn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e1ng tin c\u1eady v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng.<\/td>\n<td style=\"width: 47.01%\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u00e1c gi\u1ea3 Brandon Cohen v\u00e0 c\u1ed9ng s\u1ef1 (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 24 th\u00e1ng 03 n\u0103m 2023). <em>Celecoxib<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 30 th\u00e1ng 10 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535359\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535359\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Paul L McCormack. (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 24 th\u00e1ng 12 n\u0103m 2011). <em>Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 30 th\u00e1ng 10 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22141388\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22141388\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Sooyoung Shin. (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 14 th\u00e1ng 12 n\u0103m 2018). <em>Safety of celecoxib versus traditional nonsteroidal anti-inflammatory drugs in older patients with arthritis<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 30 th\u00e1ng 10 n\u0103m 2023, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30588073\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30588073\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Agilecox 200 ch\u1ee9a ho\u1ea1t ch\u1ea5t Celecoxib v\u1edbi h\u00e0m l\u01b0\u1ee3ng 200mg \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi m\u1ee5c \u0111\u00edch l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng trong: vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam x\u01b0\u01a1ng kh\u1edbp v\u00e0 vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp<\/p>\n","protected":false},"author":490,"featured_media":53319,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-53318","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/53318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=53318"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/53319"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=53318"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=53318"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=53318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}