{"id":50540,"date":"2023-10-22T20:34:30","date_gmt":"2023-10-22T13:34:30","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=50540"},"modified":"2025-07-24T14:00:04","modified_gmt":"2025-07-24T07:00:04","slug":"thuoc-enaplus-hct-5-12-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-enaplus-hct-5-12-5\/","title":{"rendered":"Enaplus HCT 5\/12.5"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n <a href=\"https:\/\/vnras.com\/drug\/thuoc-enaplus-hct-5-12-5\/\">thu\u1ed1c Enaplus HCT 5\/12.5<\/a> l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p 2 th\u00e0nh ph\u1ea7n Enalapril v\u00e0 Hydroclorothiazid, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng t\u0103ng huy\u1ebft \u00e1p. Thu\u1ed1c Enaplus HCT 5\/12.5 l\u00e0 s\u1ea3n ph\u1ea9m c\u1ee7a D\u01b0\u1ee3c ph\u1ea9m Li\u00ean doanh Stellapharm &#8211; Vi\u1ec7t Nam, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh trong n\u01b0\u1edbc l\u00e0 VD-34906-20.<\/strong><\/p>\n<h2>Enaplus HCT 5\/12.5 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Thu\u1ed1c Enaplus HCT 5\/12.5<\/strong> c\u00f3 ch\u1ee9a c\u00e1c th\u00e0nh ph\u1ea7n sau \u0111\u00e2y:<\/p>\n<ul>\n<li>Enalapril maleate h\u00e0m l\u01b0\u1ee3ng 5mg + Hydrochlorothiazide h\u00e0m l\u01b0\u1ee3ng 12.5mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-34906-20.<\/p>\n<p>\u0110\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim..<\/p>\n<p>Xu\u1ea5t x\u1ee9: D\u01b0\u1ee3c ph\u1ea9m Li\u00ean doanh Stellapharm &#8211; Vi\u1ec7t Nam.<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Enaplus HCT 5\/12.5<\/h2>\n<table style=\"border-collapse: collapse;width: 100%;height: 63px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td style=\"width: 31.0686%;height: 21px;text-align: center\">Th\u00e0nh ph\u1ea7n<\/td>\n<td style=\"width: 36.6095%;height: 21px;text-align: center\">Enalapril maleate<\/td>\n<td style=\"width: 32.3219%;height: 21px;text-align: center\">Hydrochlorothiazide<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 31.0686%;height: 21px\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/td>\n<td style=\"width: 36.6095%;height: 21px\">Enalapril thu\u1ed9c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (Angiotensin Converting Enzyme Inhibitors \u2013 ACEIs)Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3, Enalaprilat c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzym chuy\u1ec3n ACE theo c\u01a1 ch\u1ebf c\u1ea1nh tranh; \u1ee9c ch\u1ebf h\u1ec7 RAA (renin \u2013 angiotensin \u2013 aldosterone) v\u00e0 ng\u0103n c\u1ea3n s\u1ef1 t\u1ea1o th\u00e0nh angiotensin II t\u1eeb angiotensin IAngiotensin II b\u1ecb b\u1ea5t ho\u1ea1t, g\u00e2y gi\u00e3n m\u1ea1ch t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m s\u1ee9c c\u1ea3n to\u00e0n b\u1ed9 ngo\u1ea1i vi; cu\u1ed1i c\u00f9ng l\u00e0 l\u00e0m h\u1ea1 huy\u1ebft \u00e1p.<\/td>\n<td style=\"width: 32.3219%;height: 21px\">Hydroclorothiazid thu\u1ed9c nh\u00f3m c\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u thiazid; t\u0103ng b\u00e0i ti\u1ebft Ion Natri, clorid v\u00e0 k\u00e9o theo n\u01b0\u1edbc do c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu c\u00e1c ion n\u00e0y \u1edf \u1ed1ng l\u01b0\u1ee3n xaT\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u1ee7a hydroclorothiazid th\u01b0\u1eddng \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u \u1edf li\u1ec1u 12,5 mg<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 31.0686%;height: 21px\">D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/td>\n<td style=\"width: 36.6095%;height: 21px\">Sau khi u\u1ed1ng, kho\u1ea3ng 60% li\u1ec1u enalapril \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1eeb \u0111\u01b0\u1eddng ti\u00eau h\u00f3a; n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 0,5 &#8211; 1,5 gi\u1edd;<\/p>\n<p>Kho\u1ea3ng 50 &#8211; 60% enalapril li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng<\/p>\n<p>T\u1ea1i gan, enalapril \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n t\u1ea1o th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh mang ho\u1ea1t t\u00ednh enalaprilat<\/p>\n<p>N\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb c\u1ee7a thu\u1ed1c kho\u1ea3ng 11 gi\u1edd; 60% li\u1ec1u enalapril ban \u0111\u1ea7u b\u00e0i ti\u1ebft theo n\u01b0\u1edbc ti\u1ec3u; ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u00e0o th\u1ea3i theo ph\u00e2n.<\/td>\n<td style=\"width: 32.3219%;height: 21px\">Hydroclorothiazid h\u1ea5p thu t\u01b0\u01a1ng \u0111\u1ed1i t\u1ed1t, kho\u1ea3ng 65 &#8211; 75% li\u1ec1u s\u1eed d\u1ee5ng, h\u1ea5p thu thu\u1ed1c gi\u1ea3m \u1edf ng\u01b0\u1eddi suy tim sung huy\u1ebft<\/p>\n<p>Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu v\u00e0 sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c<\/p>\n<p>Hydroclorothiazid t\u00edch l\u0169y trong h\u1ed3ng c\u1ea7u; t\u1ef7 l\u1ec7 li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng 40 &#8211; 68%; qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o nhau thai v\u00e0 c\u00f3 trong s\u1eefa m\u1eb9<\/p>\n<p>Th\u1ea3i tr\u1eeb thu\u1ed1c ch\u1ee7 y\u1ebfu tr\u00ean th\u1eadn, \u1edf d\u1ea1ng kh\u00f4ng chuy\u1ec3n h\u00f3a; t1\/2 c\u1ee7a hydroclorothiazid kho\u1ea3ng 9,5 &#8211; 13 gi\u1edd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Thu\u1ed1c Enaplus HCT 5\/12.5 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh huy\u1ebft \u00e1p khi \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n \u0111\u1ed9c v\u1edbi enalapril ho\u1eb7c hydrochlorothiazide theo c\u00f9ng 1 t\u1ec9 l\u1ec7 h\u00e0m l\u01b0\u1ee3ng.<\/p>\n<h2>Li\u1ec1u d\u00f9ng &#8211; c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Enaplus HCT 5\/12.5<\/h2>\n<h3>Thu\u1ed1c Enaplus HCT 5\/12.5 \u0111\u01b0\u1eddng d\u00f9ng l\u00e0 gi?<\/h3>\n<p>Enaplus HCT 5\/12.5 d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, u\u1ed1ng thu\u1ed1c c\u00f9ng n\u01b0\u1edbc l\u1ecdc th\u00f4ng th\u01b0\u1eddng<\/p>\n<p>Do th\u1ee9c \u0103n l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng v\u00e0 k\u00e9o d\u00e0i th\u1eddi gian \u0111\u00e0o th\u1ea3i c\u1ee7a thu\u1ed1c n\u00ean u\u1ed1ng sau khi \u0103n kho\u1ea3ng 30 ph\u00fat \u2013 1 gi\u1edd.<\/p>\n<h3>Li\u1ec1u d\u00f9ng thu\u1ed1c Enaplus HCT 5\/12.5<\/h3>\n<p>Li\u1ec1u \u0111\u01a1n \u0111\u1ed9c<\/p>\n<h4>Kho\u1ea3ng cho t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a enalapril l\u00e0 10 \u2013 40 mg\/ng\u00e0y, chia th\u00e0nh 1-2 l\u1ea7n d\u00f9ng trong ng\u00e0y<\/h4>\n<h4>Li\u1ec1u c\u00f3 hi\u1ec7u qu\u1ea3 c\u1ee7a hydrochlorothiazide l\u00e0 12,5 \u2013 50 mg\/ng\u00e0y.<\/h4>\n<p>Li\u1ec1u ph\u1ed1i h\u1ee3p<\/p>\n<p>B\u1ec7nh nh\u00e2n kh\u00f4ng cho c\u1ea3i thi\u1ec7n huy\u1ebft \u00e1p khi d\u00f9ng \u0111\u01a1n \u0111\u1ed9c enalapril ho\u1eb7c hydrochlorothiazide c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p enalapril maleate v\u00e0 hydrochlorothiazide<\/p>\n<p>Li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng: 1-2 vi\u00ean chia th\u00e0nh 1-2 l\u1ea7n\/ ng\u00e0y.<\/p>\n<p>S\u1ef1 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ea7n d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ea3i thi\u1ec7n c\u1ee7a b\u1ec7nh nh\u00e2n. Kho\u1ea3ng c\u00e1ch t\u0103ng li\u1ec1u c\u1ee7a hydrochlorothiazide t\u1ed1i thi\u1ec3u l\u00e0 2 \u2013 3 tu\u1ea7n.<\/p>\n<p>Li\u1ec1u d\u00f9ng t\u1ed1i \u0111a kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 4 vi\u00ean Enaplus HCT 5\/12.5 m\u1ed7i ng\u00e0y.<\/p>\n<p>Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinine Clcr &gt; 30 mL\/ph\u00fat\/1,73 m2<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Enaplus HCT 5\/12.5 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi c\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c d\u1eabn ch\u1ea5t sulfonamide.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinine \u2264 30 ml\/ph\u00fat); \u0111ang b\u1ecb v\u00f4 ni\u1ec7u ho\u1eb7c H\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn.<\/p>\n<p>Ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch th\u1ea7n kinh li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf ACE tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Ph\u00f9 m\u1ea1ch b\u1ea9m sinh ho\u1eb7c t\u1ef1 ph\u00e1t.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai trong qu\u00fd hai v\u00e0 qu\u00fd ba c\u1ee7a thai k\u1ef3.<\/p>\n<p>Ng\u01b0\u1eddi suy gan n\u1eb7ng.<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Enaplus HCT 5\/12.5 v\u1edbi c\u00e1c thu\u1ed1c ch\u1ee9a aliskiren \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn (GFR &lt; 60 ml\/ph\u00fat\/1,73 m2).<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Enaplus HCT 5\/12.5<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ki\u1ec3m tra \u0111\u1ecbnh k\u1ef3 n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec7n gi\u1ea3i huy\u1ebft thanh; \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n b\u1ecb gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n; ng\u01b0\u1eddi thi\u1ebfu m\u00e1u tim c\u1ee5c b\u1ed9; b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o ho\u1eb7c suy tim n\u1eb7ng.<\/p>\n<p>Ng\u01b0ng d\u00f9ng thu\u1ed1c n\u1ebfu x\u00e9t nghi\u1ec7m th\u1ea5y ure v\u00e0 creatinin m\u00e1u t\u0103ng<\/p>\n<p>Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u1edbi Enaplus c\u1ea7n k\u00e8m theo khuy\u1ebfn c\u00e1o theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn, ch\u1ea5t \u0111i\u1ec7n gi\u1ea3i v\u00e0 huy\u1ebft \u00e1p m\u1ed9t c\u00e1ch ch\u1eb7t ch\u1ebd.<\/p>\n<p>Enaplus HCT 5\/12.5 ch\u1ee9a lactose; kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi c\u00f3 c\u00e1c v\u1ea5n \u0111\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p v\u1ec1 kh\u1ea3 n\u0103ng dung n\u1ea1p galactose, b\u1ec7nh nh\u00e2n thi\u1ebfu enzym lactase to\u00e0n ph\u1ea7n ho\u1eb7c r\u1ed1i lo\u1ea1n h\u1ea5p thu glucose-galactose<\/p>\n<p>Th\u1eadn tr\u1ecdng \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi m\u1eafc b\u1ec7nh collagen m\u1ea1ch m\u00e1u, b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, ho\u0103c \u0111ang c\u00f3 ch\u1ec9 \u0111\u1ecbnh v\u01a1i allopurinol; procainamide, \u0111\u1eb7c bi\u1ec7t c\u00f3 ti\u1ec1n s\u1eed suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng<\/p>\n<p>Qu\u00e1 m\u1eabn bao g\u1ed3m ph\u00f9 \u1edf m\u1eb7t, tay ch\u00e2n, m\u00f4i, l\u01b0\u1ee1i, thanh m\u00f4n v\u00e0\/ho\u1eb7c thanh qu\u1ea3n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi \u0111i\u1ec1u tri v\u1edbi Enaplus HCT 5\/12.5<\/p>\n<p>D\u00f9ng thu\u1ed1c th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch, ng\u01b0\u1eddi \u0111ang d\u00f9ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c \u1ee9c ch\u1ebf ACE v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf mTOR.<\/p>\n<p>Thiazide c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m dung n\u1ea1p glucose; gi\u1ea3m n\u1ed3ng \u0111\u1ed9 natri, magnesi v\u00e0 kali huy\u1ebft thanh; gi\u1ea3m b\u00e0i ti\u1ebft calci qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 g\u00e2y ra s\u1ef1 t\u0103ng n\u1ed3ng \u0111\u1ed9 calci huy\u1ebft thanh nh\u1eb9.<\/p>\n<p>V\u1edbi b\u1ec7nh nh\u00e2n x\u01a1 gan, b\u00e0i ni\u1ec7u nhanh, ng\u01b0\u1eddi kh\u00f4ng b\u1ed5 sung \u0111\u1ea7y \u0111\u1ee7 c\u00e1c ch\u1ea5t \u0111i\u1ec7n gi\u1ea3i,ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi v\u1edbi corticosteroid ho\u1eb7c ACTH; s\u1eed d\u1ee5ng hydrochlorothiazide c\u00f3 th\u1ec3 g\u00e2y m\u1ea5t c\u00e2n b\u1eb1ng d\u1ecbch v\u00e0 \u0111i\u1ec7n gi\u1ea3i.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 38.7863%;text-align: center\">T\u1ea7n su\u1ea5t (ADR)<\/td>\n<td style=\"width: 61.2137%;text-align: center\">T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 38.7863%\">R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/td>\n<td style=\"width: 61.2137%\">Nh\u00ecn m\u1edd<\/p>\n<p>Ch\u00f3ng m\u1eb7t<\/p>\n<p>Ho<\/p>\n<p>Bu\u1ed3n n\u00f4n<\/p>\n<p>Suy nh\u01b0\u1ee3c c\u01a1 th\u1ec3<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 38.7863%\">Th\u01b0\u1eddng g\u1eb7p<\/td>\n<td style=\"width: 61.2137%\">R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a: H\u1ea1 kali huy\u1ebft, t\u0103ng cholesterol v\u00e0 triglyceride m\u00e1u, acid uric m\u00e1u t\u0103ng; T\u0103ng ch\u1ec9 s\u1ed1 kali huy\u1ebft v\u00e0 creatinine huy\u1ebft thanh<\/p>\n<p>Th\u1ea7n kinh: \u0110au \u0111\u1ea7u, tr\u1ea7m c\u1ea3m, ng\u1ea5t, thay \u0111\u1ed5i v\u1ecb gi\u00e1c;<\/p>\n<p>Tim m\u1ea1ch: H\u1ea1 huy\u1ebft \u00e1p, h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng, lo\u1ea1n nh\u1ecbp tim, xu\u1ea5t hi\u1ec7n c\u01a1n \u0111au th\u1eaft ng\u1ef1c, t\u0103ng nh\u1ecbp tim;<\/p>\n<p>H\u00f4 h\u1ea5p: Kh\u00f3 th\u1edf;<\/p>\n<p>Ti\u00eau h\u00f3a: Ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng;<\/p>\n<p>Qu\u00e1 m\u1eabn: Ph\u00e1t ban\/ph\u00f9 (ph\u00f9 m\u1ea1ch \u1edf m\u1eb7t, chi, m\u00f4i, l\u01b0\u1ee1i, thanh m\u00f4n v\u00e0\/ho\u1eb7c thanh qu\u1ea3n);<\/p>\n<p>To\u00e0n th\u00e2n: Co c\u1ee9ng c\u01a1; \u0111au ng\u1ef1c, m\u1ec7t m\u1ecfi;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<h4>T\u01b0\u01a1ng t\u00e1c v\u1edbi th\u00e0nh ph\u1ea7n Enalapril<\/h4>\n<p>C\u00e1c thu\u1ed1c b\u1ed5 sung kali, thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali hay c\u00e1c ch\u1ea5t thay th\u1ebf mu\u1ed1i ch\u1ee9a kali: s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00f9ng enalapril l\u00e0m n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh<\/p>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u: c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Lithi: t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft d\u1eabn \u0111\u1ebfn nhi\u1ec5m \u0111\u1ed9c lithi.<\/p>\n<p>C\u00e1c thu\u1ed1c gi\u00e3n m\u1ea1ch kh\u00e1c (v\u00ed d\u1ee5 nitrat) ho\u1eb7c c\u00e1c thu\u1ed1c g\u00e2y m\u00ea: c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p tr\u1ea7m tr\u1ecdng khi d\u00f9ng c\u00f9ng Enalapril<\/p>\n<p>Thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n, NSAIDs: c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a enalapril.<\/p>\n<h4>T\u01b0\u01a1ng t\u00e1c v\u1edbi th\u00e0nh ph\u1ea7n Hydroclorothiazid<\/h4>\n<p>Thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng d\u1ea1ng u\u1ed1ng ho\u1eb7c insulin: Enaplus c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a thu\u1ed1c; \u0111i\u1ec1u ch\u00ecnh li\u1ec1u n\u1ebfu c\u1ea7n<\/p>\n<p>C\u00e1c thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c: hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng; c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c<\/p>\n<p>Corticosteroid, ACTH, Salbutamol, carbenoxolon, amphotericin B ho\u1eb7c reboxetine: t\u0103ng kh\u1ea3 n\u0103ng xu\u1ea5t hi\u1ec7n c\u00e1c r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i<\/p>\n<p>Thu\u1ed1c gi\u00e3n c\u01a1 kh\u00f4ng kh\u1eed c\u1ef1c (tubocurarine): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u00e1p \u1ee9ng gi\u00e3n c\u01a1 c\u1ee7a thu\u1ed1c.<\/p>\n<p>Quinidin: D\u1ec5 g\u00e2y xo\u1eafn \u0111\u1ec9nh, l\u00e0m rung th\u1ea5t g\u00e2y t\u1eed vong.<\/p>\n<p>Nh\u1ef1a cholestyramin ho\u1eb7c colestipol: gi\u1ea3m kh\u1ea3 n\u0103ng h\u1ea5p thu c\u1ee7a Hydroclorothiazid<\/p>\n<p>Allopurinol, tetracyclin: T\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a c\u00e1c thu\u1ed1c<\/p>\n<p>C\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u Thiazid l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u, thu\u1ed1c \u0111i\u1ec1u tr\u1ecb g\u00fat; l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c g\u00e2y m\u00ea, glycosid v\u00e0 Vitamin D<\/p>\n<h3>L\u01b0u \u00fd khi d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Enaplus HCT 5\/12.5 trong ba th\u00e1ng \u0111\u1ea7u thai k\u1ef3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong qu\u00fd hai v\u00e0 qu\u00fd ba c\u1ee7a thai k\u1ef3.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng Enaplus HCT 5\/12.5 trong th\u1eddi k\u1ef3 cho con b\u00fa kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o. N\u1ebfu Enaplus HCT 5\/12.5 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 cho con b\u00fa, n\u00ean duy tr\u00ec li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 th\u1ec3.<\/p>\n<h3>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y hoa m\u1eaft, ch\u00f3ng m\u1eb7t \u0111\u00f4i khi l\u00e0 h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ec3, c\u1ea7n l\u01b0u \u00fd n\u1ebfu ph\u1ea3i l\u00e1i xe hay \u0111i\u1ec1u khi\u1ec7n m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<h4>Ch\u01b0a c\u00f3 th\u00f4ng tin c\u1ee5 th\u1ec3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o<\/h4>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n n\u01a1i kh\u00f4 tho\u00e1ng, tr\u00e1nh \u00e1nh s\u00e1ng m\u1ea1nh, nhi\u1ec7t \u0111\u1ed9 duy tr\u00ec d\u01b0\u1edbi 30\u00b0C<\/p>\n<h2>Enaplus HCT 5\/12.5 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c Enaplus HCT 5\/12.5 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 Enaplus HCT 5\/12.5<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c nh\u01b0:<\/p>\n<ul>\n<li>.Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/enalapril\/\">Enalapril<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Enalapril; \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n, th\u01b0\u1eddng d\u00f9ng ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n, do b\u1ec7nh l\u00ed th\u1eadn, b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 suy tim c\u00e1c m\u1ee9c \u0111\u1ed9. Thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n ph\u1ed1i b\u1edfi D\u01b0\u1ee3c ph\u1ea9m Domesco; h\u1ed9p 30 vi\u00ean c\u00f3 gi\u00e1 20.000 \u0111\u1ed3ng m\u1ed9t h\u1ed9p.<\/li>\n<li><a href=\"https:\/\/vnras.com\/drug\/valsgim-h-160-12-5\/\"> Valsgim-H 160\/12.5<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Agimexpharm. C\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-25129-16 v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh Valsartan 10mg v\u00e0 Hydroclorothiazid 12.5mg; l\u00e0 li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p trong \u0111i\u1ec1u tr\u1ecb cao huy\u1ebft \u00e1p. H\u1ed9p 2 v\u1ec9 x 14 vi\u00ean Valsgim-H 160\/12.5 hi\u1ec7n \u0111ang c\u00f3 gi\u00e1 190.000 \u0111\u1ed3ng.<\/li>\n<\/ul>\n<h2>T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn Enaplus HCT 5\/12.5?<\/h2>\n<table style=\"border-collapse: collapse;width: 100%;height: 149px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td style=\"width: 53.7694%;height: 21px;text-align: center\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 46.2306%;height: 21px;text-align: center\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr style=\"height: 86px\">\n<td style=\"width: 53.7694%;height: 86px\">Thu\u1ed1c Enaplus HCT 5\/12.5 l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a 2 ho\u1ea1t ch\u1ea5t; hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng v\u00e0 cho hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t t\u1ed1t huy\u1ebft \u00e1p m\u00e0 kh\u00f4ng gia t\u0103ng \u0111\u1ed9c t\u00ednh khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Enalapril v\u00e0 hydrochlorothiazide \u0111\u01b0\u1ee3c coi l\u00e0 c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p \u0111\u1ea7u tay, an to\u00e0n \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 ng\u01b0\u1eddi m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng c\u00f3 t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Ph\u1ed1i h\u1ee3p enalapril\/HCTZ c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi c\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng huy\u1ebft \u00e1p t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng, v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n nhi\u1ec1u so v\u1edbi khi s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c c\u00e1c thu\u1ed1c<\/p>\n<p>T\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a enalapril \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng b\u1edfi hydrochlorothiazide<\/p>\n<p>\u0110\u1ed3ng th\u1eddi khi k\u1ebft h\u1ee3p Enalapril gi\u1ea3m c\u01b0\u1eddng aldosteron th\u1ee9 ph\u00e1t v\u00e0 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng h\u1ea1 kali m\u00e1u do\u00a0 thu\u1ed1c l\u1ee3i ti\u1ec3u hydrochlorothiazide g\u00e2y ra.<\/p>\n<p>Tthu\u1ed1c Enaplus HCT 5\/12.5 \u0111\u01b0\u1ee3c cung c\u1ea5p b\u1edfi C\u00f4ng ty TNHH Li\u00ean doanh Stellapharm, 1 trong nh\u1eefng \u0111\u01a1n v\u1ecb d\u01b0\u1ee3c ph\u1ea9m h\u00e0ng \u0111\u1ea7u v\u1edbi trang thi\u1ebft b\u1ecb v\u00e0 ti\u00eau chu\u1ea9n qu\u1ed1c t\u1ebf, \u0111\u01b0\u1ee3c tin d\u00f9ng trong n\u01b0\u1edbc<\/p>\n<p>Enaplus HCT l\u00e0 thu\u1ed1c c\u00f3 d\u1ea1ng vi\u00ean n\u00e9n bao phim nh\u1ecf g\u1ecdn; li\u1ec1u d\u00f9ng \u0111\u01a1n gi\u1ea3n 1 -2 vi\u00ean m\u1ed7i ng\u00e0y; gi\u1ea3m thi\u1ec3u g\u00e1nh n\u1eb7ng d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi b\u1ec7nh<\/p>\n<p>Gi\u00e1 th\u00e0nh ph\u1ea3i ch\u0103ng, d\u1ec5 t\u00ecm mua \u1edf nh\u00e0 thu\u1ed1c<\/td>\n<td style=\"width: 46.2306%;height: 86px\">Vi\u1ec7c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p ch\u1ec9 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh khi c\u00e1c li\u1ec7u ph\u00e1p \u0111\u01a1n tr\u1ecb li\u1ec7u kh\u00f4ng dung n\u1ea1p.<\/p>\n<p>Li\u1ec1u d\u00f9ng c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i v\u00e0 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a theo \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n c\u1ee5 th\u1ec3<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u00e1c gi\u1ea3: Vaisse B, Souchet T, Delage Y v\u00e0 Poggi L (Ng\u00e0y \u0111\u0103ng: th\u00e1ng 1 n\u0103m 1991). <em>[Comparative study of enalapril, hydrochlorothiazide and their combination in the treatment of essential hypertension<\/em>]. Truy c\u1eadp ng\u00e0y 22 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2024911\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/2024911\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Carey RM, Moran AE, Whelton PK (Ng\u00e0y \u0111\u0103ng: th\u00e1ng 11 n\u0103m 2022).<em> Treatment of Hypertension: A Review..<\/em> Truy c\u1eadp ng\u00e0y 22 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36346411\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36346411\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Arjumand Faruqi, Ashish Jain (Ng\u00e0y \u0111\u0103ng: th\u00e1ng 1 n\u0103m 2023). <em>Enalapril<\/em><i>. <\/i>Truy c\u1eadp ng\u00e0y 22 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557708\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557708\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Enaplus HCT 5\/12.5 l\u00e0 thu\u1ed1c k\u1ebft h\u1ee3p Enalapril v\u00e0 Hydrochlorothiazide, h\u1ed9p 3 v\u1ec9 x 10 vi\u00ean c\u1ee7a D\u01b0\u1ee3c ph\u1ea9m Stella &#8211; Vi\u1ec7t Nam<\/p>\n","protected":false},"author":490,"featured_media":50555,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-50540","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/50540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=50540"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/50555"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=50540"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=50540"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=50540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}