{"id":50511,"date":"2023-10-21T21:52:47","date_gmt":"2023-10-21T14:52:47","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=50511"},"modified":"2025-07-24T14:00:04","modified_gmt":"2025-07-24T07:00:04","slug":"thuoc-cinasav-10","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-cinasav-10\/","title":{"rendered":"Cinasav 10"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n <a href=\"https:\/\/vnras.com\/drug\/thuoc-cinasav-10\/\">thu\u1ed1c Cinasav 10<\/a> l\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi m\u1eafc tr\u1ea7m c\u1ea3m n\u1eb7ng; ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 Citalopram hydrobromid, do D\u01b0\u1ee3c ph\u1ea9m SaviPharm s\u1ea3n xu\u1ea5t v\u00e0 ph\u00e2n ph\u1ed1i, v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh l\u00e0 VD-28017-17.<\/strong><\/p>\n<h2>Cinasav 10 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Thu\u1ed1c Cinasav 10<\/strong> c\u00f3 ch\u1ee9a c\u00e1c th\u00e0nh ph\u1ea7n sau \u0111\u00e2y:<\/p>\n<ul>\n<li>Citalopram hydrobromid: h\u00e0m l\u01b0\u1ee3ng 10mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-28017-17.<\/p>\n<p>\u0110\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim..<\/p>\n<p>Xu\u1ea5t x\u1ee9: D\u01b0\u1ee3c ph\u1ea9m SaviPharm &#8211; Vi\u1ec7t Nam.<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Cinasav 10<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Citalopram l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu ch\u1ecdn l\u1ecdc serotonin (SSRI). Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng ho\u1eb7c \u1ea3nh h\u01b0\u1edfng r\u1ea5t \u00edt \u0111\u1ebfn c\u00e1c ch\u1ea5t d\u1eabn truy\u1ec1n kh\u00e1c nh\u01b0 noradrenalin, dopamin v\u00e0 acid gamma aminobutyric (GABA).<\/p>\n<p>Thu\u1ed1c kh\u00f4ng c\u00f3 ho\u1eb7c c\u00f3 \u00e1i l\u1ef1c r\u1ea5t th\u1ea5p \u0111\u1ed1i v\u1edbi h\u1ea7u h\u1ebft c\u00e1c th\u1ee5 th\u1ec3 kh\u00e1c; bao g\u1ed3m 5-HT1A, 5-HT2, Dopamin D1 v\u00e0 D2; c\u00e1c th\u1ee5 th\u1ec3 alpha1, alpha2 v\u00e0 beta adrenergic, histamin H1, th\u1ee5 th\u1ec3 muscarin, benzodiazepin v\u00e0 c\u1ea3 opioid.<\/p>\n<p>Do \u0111\u00f3, citalopram kh\u00f4ng g\u00e2y nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c; kh\u00f4ng g\u00e2y t\u00ecnh tr\u1ea1ng: kh\u00f4 mi\u1ec7ng, r\u1ed1i lo\u1ea1n b\u00e0ng quang, lo\u1ea1n khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t, suy gi\u1ea3m th\u1ecb l\u01b0c; kh\u00f4ng g\u00e2y \u0111\u1ed9c t\u00ednh tr\u00ean tim v\u00e0 kh\u00f4ng l\u00e0m xu\u1ea5t hi\u1ec7n h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng.<\/p>\n<p>S\u1eed d\u1ee5ng citalopram kh\u00f4ng c\u00f3\/ r\u1ea5t \u00edt cho t\u00e1c d\u1ee5ng an th\u1ea7n; kh\u00f4ng \u1ee9c ch\u1ebf th\u1ea7n kinh do \u0111\u00f3 kh\u00f4ng l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng c\u1ee7a nh\u1eadn th\u1ee9c v\u00e0 v\u1eadn \u0111\u1ed9ng.<\/p>\n<p>Citalopram kh\u00f4ng l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 prolactin v\u00e0 hormon t\u0103ng tr\u01b0\u1edfng.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Thu\u1ed1c h\u1ea5p thu g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n. Th\u1eddi gian thu\u1ed1c \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong m\u00e1u l\u00e0 3,8 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 80%.<\/p>\n<p>Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 to\u00e0n th\u00e2n c\u1ee7a citalopram l\u00e0 12,3 lit\/kg. T\u1ef7 l\u1ec7 g\u1eafn k\u1ebft protetin huy\u1ebft t\u01b0\u01a1ng c\u1ee7a citalopram v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh \u0111\u1ec1u d\u01b0\u1edbi 80%. Thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o m\u00e1u &#8211; n\u00e3o.<\/p>\n<p>Chuy\u1ec3n h\u00f3a thu\u1ed1c x\u1ea3y ra d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c h\u1ec7 enzym CYP3A4 v\u00e0 CYP 2C19 c\u00f3 m\u1eb7t t\u1ea1i gan. S\u1ea3n ph\u1ea9m chuy\u1ec3n h\u00f3a l\u00e0 c\u00e1c d\u1eabn ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh bao g\u1ed3m demethylcitalopram, didemethylcitalopram v\u00e0 citalopram-N-oxid.<\/p>\n<p>Th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua gan (85%) v\u00e0 th\u1eadn (15%), n\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb c\u1ee7a Citalopram k\u00e9o d\u00e0i t\u1edbi 1,5 ng\u00e0y \u1edf ng\u01b0\u1eddi c\u00f3 ch\u1ee9c n\u0103ng gan, th\u1eadn b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>Thu\u1ed1c \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau 1 &#8211; 2 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb. Kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean quan r\u00f5 r\u00e0ng gi\u1eefa n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u v\u1edbi \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb hay ADR.<\/p>\n<p><em>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/em><\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i ( tr\u00ean 65 tu\u1ed5i): Chuy\u1ec3n h\u00f3a c\u1ee7a citalopram gi\u1ea3m khi d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi; \u0111\u1ed9 thanh th\u1ea3i gi\u1ea3m v\u00e0 n\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb c\u1ee7a thu\u1ed1c t\u0103ng l\u00ean so v\u1edbi b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan: th\u1eddi gian th\u1ea3i tr\u1eeb v\u00e0 n\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh trong m\u00e1u t\u0103ng g\u1ea5p \u0111\u00f4i so v\u1edbi b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn: Kh\u00f4ng c\u00f3 kh\u00e1c bi\u1ec7t nhi\u1ec1u v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a citalopram \u1edf ng\u01b0\u1eddi suy th\u1eadn nh\u1eb9 v\u00e0 trung b\u00ecnh.<\/p>\n<h2>Thu\u1ed1c Cinasav 10 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Citalopram hydrobromid \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n tr\u1ea7m c\u1ea3m n\u1eb7ng DSM-III v\u00e0 DSM-III-R k\u00e9o d\u00e0i 4-6 tu\u1ea7n \u1edf c\u00e1c b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa.<\/p>\n<h2>Li\u1ec1u d\u00f9ng &#8211; c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Cinasav 10<\/h2>\n<h3>Thu\u1ed1c Cinasav 10 \u0111\u01b0\u1eddng d\u00f9ng l\u00e0 gi?<\/h3>\n<p>Cinasav 10 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, u\u1ed1ng thu\u1ed1c c\u00f9ng 1 c\u1ed1c n\u01b0\u1edbc \u0111\u1ea7y.<\/p>\n<p>Nu\u1ed1t nguy\u00ean vi\u00ean; kh\u00f4ng \u0111\u01b0\u1ee3c nhai, ng\u1eadm hay nghi\u1ec1n n\u00e1t vi\u00ean.<\/p>\n<p>Citalopram n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng v\u00e0o m\u1ed9t l\u1ea7n duy nh\u1ea5t m\u1ed7i ng\u00e0y, s\u00e1ng\/t\u1ed1i, c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/p>\n<h3>Li\u1ec1u d\u00f9ng thu\u1ed1c Cinasav 10<\/h3>\n<h4>\u0110i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m<\/h4>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: U\u1ed1ng 2 vi\u00ean\/l\u1ea7n x 1 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n<p>Li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 t\u0103ng m\u1ed7i 2 vi\u00ean\/ng\u00e0y, sau khi \u0111i\u1ec1u tr\u1ecb 3 &#8211; 4 tu\u1ea7n; li\u1ec1u t\u1ed1i \u0111a \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0 4 vi\u00ean\/ng\u00e0y.<\/p>\n<p>B\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m c\u1ea7n \u0111i\u1ec1u tr\u1ecb \u00edt nh\u1ea5t 6 th\u00e1ng \u0111\u1ec3 gi\u1ea3i quy\u1ebft h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: b\u1eaft \u0111\u1ea7u \u1edf li\u1ec1u 1 vi\u00ean m\u1ed7i ng\u00e0y v\u00e0 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. Li\u1ec1u duy tr\u00ec n\u00ean l\u00e0 1-2 vi\u00ean h\u00e0ng ng\u00e0y.<\/p>\n<h4>R\u1ed1i lo\u1ea1n lo \u00e2u ho\u1ea3ng s\u1ee3<\/h4>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: Li\u1ec1u 1 vi\u00ean\/l\u1ea7n, 1 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n<p>Li\u1ec1u duy tr\u00ec th\u00f4ng th\u01b0\u1eddng: l\u00e0 2-3 vi\u00ean\/ng\u00e0y; t\u1ed1i \u0111a kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 l\u01b0\u1ee3ng 4 vi\u00ean trong 24 gi\u1edd<\/p>\n<h4>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/h4>\n<p><strong><em>B\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan nh\u1eb9 &#8211; trung b\u00ecnh:<\/em><\/strong><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u 1 vi\u00ean m\u1ed7i ng\u00e0y trong 2 tu\u1ea7n \u0111\u1ea7u<\/p>\n<p>T\u00f9y thu\u1ed9c \u0111\u00e1p \u1ee9ng, li\u1ec1u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u0103ng l\u00ean \u0111\u1ebfn t\u1ed1i \u0111a l\u00e0 2 vi\u00ean\/ng\u00e0y.<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi ng\u01b0\u1eddi b\u1ecb suy gan n\u1eb7ng<\/p>\n<p><em><strong>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/strong><\/em><\/p>\n<p>Nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng (Clcr &lt; 20 ml\/ph\u00fat): Kh\u00f4ng d\u00f9ng thu\u1ed1c cho \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y<\/p>\n<p><em><strong>B\u1ec7nh nh\u00e2n gi\u1ea3m chuy\u1ec3n h\u00f3a CYP 2C19:<\/strong><\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 1 vi\u00ean\/ng\u00e0y, trong 2 tu\u1ea7n \u0111\u1ea7u ti\u00ean. Sau \u0111\u00f3 c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean t\u1ed1i \u0111a 2 vi\u00ean m\u1ed7i ng\u00e0y t\u00f9y thu\u1ed9c \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Cinasav 10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi citalopram ho\u1eb7c v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o kh\u00e1c c\u1ee7a thu\u1ed1c.<\/p>\n<p>Kh\u00f4ng d\u00f9ng c\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf monoamin oxidase (MAO).<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh li\u1ec1u t\u1eeb 20mg citalopram tr\u1edf l\u00ean \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i (&gt; 60 tu\u1ed5i) vi nguy c\u01a1 cao g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 cao g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3, bao g\u1ed3m: b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i b\u1ecb tr\u1ea7m c\u1ea3m; ng\u01b0\u1eddi c\u00f3 h\u1ed9i ch\u1ee9ng k\u00e9o d\u00e0i QT b\u1ea9m sinh, nh\u1ecbp tim ch\u1eadm, n\u1ed3ng \u0111\u1ed9 kali v\u00e0 magnesi trong m\u00e1u th\u1ea5p, nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p ho\u1eb7c b\u1ec7nh nh\u00e2n b\u1ecb suy tim m\u1ea5t b\u00f9<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng citalopram cho b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c kh\u1ea3 n\u0103ng g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng d\u00f9ng chung \u0111\u1ed3ng th\u1eddi v\u1edbi cimetidin, r\u01b0\u1ee3u<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Cinasav 10<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb l\u00e2u h\u01a1n th\u1eddi gian n\u00e0y \u0111\u1ed1i v\u1edbi Citalopram ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u ch\u00ednh x\u00e1c, n\u1ebfu ch\u1ec9 \u0111\u1ecbnh k\u00e9o d\u00e0i c\u1ea7n h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng v\u00e0 \u0111\u00e1nh gi\u00e1 \u0111\u1ecbnh k\u1ef3 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c v\u1edbi ng\u01b0\u1eddi d\u00f9ng.<\/p>\n<p>S\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n cao tu\u1ed5i v\u00e0 ng\u01b0\u1eddi b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng gan, th\u1eadn<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng citalopram cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i do d\u1eef li\u1ec7u v\u1ec1 \u0111\u1ed9 an to\u00e0n d\u00e0i h\u1ea1n \u1edf tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean li\u00ean quan \u0111\u1ebfn ph\u00e1t tri\u1ec3n, nh\u1eadn th\u1ee9c v\u1eabn c\u00f2n ch\u01b0a \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p>B\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m c\u00f3 th\u1ec3 l\u00e0m t\u0103ng tri\u1ec7u ch\u1ee9ng lo \u00e2u tr\u00ean m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n m\u1eafc r\u1ed1i lo\u1ea1n ho\u1ea3ng s\u1ee3.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i v\u1ec1 vi\u1ec7c xu\u1ea5t hi\u1ec7n \u00fd ngh\u0129 t\u1ef1 s\u00e1t\/t\u1ef1 s\u00e1t ho\u1eb7c t\u00ecnh tr\u1ea1ng b\u1ec7nh x\u1ea5u \u0111i; \u0111\u1eb7c bi\u1ec7t l\u00e0 trong th\u1eddi gian \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb c\u0169ng nh\u01b0 ph\u1ee5c h\u1ed3i sau \u0111\u00f3,<\/p>\n<p>N\u1ebfu ph\u1ea3i k\u00ea \u0111\u01a1n cho \u0111\u1ed1i t\u01b0\u1ee3ng c\u00f3 nguy c\u01a1 t\u1ef1 s\u00e1t cao, n\u00ean ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c, \u0111\u1eb7c bi\u1ec7t trong giai \u0111o\u1ea1n \u0111i\u1ec1u tr\u1ecb s\u1edbm v\u00e0 sau khi thay \u0111\u1ed5i li\u1ec1u<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c SSRI c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. Li\u1ec1u Insulin v\u00e0 c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 th\u1ec3 ph\u1ea3i hi\u1ec7u ch\u00ednh.<\/p>\n<p>Ng\u1eebng d\u00f9ng citalopram n\u1ebfu b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n ho\u1eb7c t\u0103ng c\u00e1c tri\u1ec7u ch\u1ee9ng, t\u1ea7n xu\u1ea5t c\u1ee7a c\u01a1n co gi\u1eadt . Kh\u00f4ng n\u00ean d\u00f9ng citalopram v\u1edbi ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9ng kinh kh\u00f4ng \u1ed5n \u0111\u1ecbnh. N\u1ebfu c\u00f3 c\u1ea7n theo d\u00f5i c\u1ea7n th\u1eadn trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Citalopram c\u00f3 th\u1ec3 l\u00e0m xu\u1ea5t hi\u1ec7n c\u00e1c c\u01a1n h\u01b0ng c\u1ea3m; \u0111\u1eb7c bi\u1ec7t l\u00e0 b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed h\u01b0ng c\u1ea3m ho\u1eb7c ng\u01b0\u1eddi b\u1ecb r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nh\u00e2n t\u00e2m th\u1ea7n trong giai \u0111o\u1ea1n tr\u1ea7m c\u1ea3m c\u00f3 th\u1ec3 l\u00e0m t\u0103ng c\u00e1c tri\u1ec7u ch\u1ee9ng lo\u1ea1n th\u1ea7n.<\/p>\n<p>C\u1ea7n l\u01b0u \u00fd v\u1ec1 t\u00ecnh tr\u1ea1ng k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u, ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng nh\u01b0 ban xu\u1ea5t huy\u1ebft, xu\u1ea5t huy\u1ebft t\u1ea1ng v\u00e0 xu\u1ea5t huy\u1ebft d\u01b0\u1edbi da khi s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c SSRI; nh\u1ea5t l\u00e0 khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng ti\u1ec3u c\u1ea7u ho\u1eb7c c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft<\/p>\n<p>H\u1ed9i ch\u1ee9ng serotonin (k\u00edch \u0111\u1ed9ng, run, rung gi\u1eadt c\u01a1 v\u00e0 th\u00e2n nhi\u1ec7t cao) \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb v\u1edbi citalopram<\/p>\n<p>B\u1ec7nh nh\u00e2n n\u1eef cao tu\u1ed5i c\u00f3 nguy c\u01a1 h\u1ea1 natri huy\u1ebft cao khi d\u00f9ng citalopram.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c SSRI ho\u1eb7c SNRI c\u00f3 th\u1ec3 l\u00e0m xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u t\u0103ng ho\u1ea1t nh\u01b0 lo l\u1eafng, b\u1ed3n ch\u1ed3n, kh\u00f3 ch\u1ecbu, \u0111i l\u1ea1i li\u00ean t\u1ee5c;\u00a0 t\u0103ng li\u1ec1u c\u00f3 th\u1ec3 t\u0103ng ADR.<\/p>\n<p>H\u1ed9i ch\u1ee9ng cai thu\u1ed1c: ng\u01b0ng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 l\u00e0m xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n c\u1ea3m gi\u00e1c, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, k\u00edch \u0111\u1ed9ng ho\u1eb7c lo \u00e2u, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a;\u00a0 run, l\u00fa l\u1eabn, \u0111\u1ed5 m\u1ed3 h\u1ed9i, \u0111au \u0111\u1ea7u, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, kh\u00f3 ch\u1ecbu v\u00e0 r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c,&#8230;<\/p>\n<p>Li\u1ec1u citalopram n\u00ean \u0111\u01b0\u1ee3c gi\u1ea3m d\u1ea7n tr\u01b0\u1edbc khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb trong m\u1ed9t kho\u1ea3ng th\u1eddi gian t\u1eeb v\u00e0i tu\u1ea7n \u0111\u1ebfn v\u00e0i th\u00e1ng t\u00f9y thu\u1ed9c \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>M\u1ee9c \u0111\u1ed9 g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT c\u1ee7a citalopram ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u. K\u00e9o d\u00e0i kho\u1ea3ng th\u1eddi gian QT v\u00e0 r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t bao g\u1ed3m c\u1ea3 xo\u1eafn \u0111\u1ec9nh \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ch\u1ee7 y\u1ebfu x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n n\u1eef, c\u00f3 t\u00ecnh tr\u1ea1ng h\u1ea1 Kali huy\u1ebft, ho\u1eb7c d\u00f9ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u r\u1ed1i lo\u1ea1n nh\u1ecbp tim x\u1ea3y ra trong khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng citalopram, n\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u00e0 th\u1ef1c hi\u1ec7n \u0111i\u1ec7n t\u00e2m \u0111\u1ed3<\/p>\n<p>Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng citalopram \u1edf b\u1ec7nh nh\u00e2n gl\u00f4c\u00f4m g\u00f3c \u0111\u00f3ng ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed t\u0103ng nh\u00e3n \u00e1p.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 50%;text-align: center\">T\u1ea7n su\u1ea5t (ADR)<\/td>\n<td style=\"width: 50%;text-align: center\">T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%\">Th\u01b0\u1eddng g\u1eb7p<\/td>\n<td style=\"width: 50%\">Th\u1ea7n kinh: \u0111au \u0111\u1ea7u.<\/p>\n<p>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: ch\u00e1n \u0103n.<\/p>\n<p>Ti\u00eau h\u00f3a: \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y, n\u00f4n, bu\u1ed3n n\u00f4n.<\/p>\n<p>M\u1eaft: r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ch\u1ec9nh m\u1eaft, nh\u00ecn m\u1edd. ADR n\u00e0y ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u v\u00e0 th\u01b0\u1eddng m\u1ea5t \u0111i khi ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n<p>Da: ph\u00e1t ban, ng\u1ee9a.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%\">\u00cdt g\u1eb7p<\/td>\n<td style=\"width: 50%\">T\u00e2m th\u1ea7n: lo l\u1eafng.<\/p>\n<p>Th\u1ea7n kinh: ch\u00f3ng m\u1eb7t.<\/p>\n<p>M\u1eaft: B\u1ec7nh v\u00f5ng m\u1ea1c<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%\">Hi\u1ebfm g\u1eb7p<\/td>\n<td style=\"width: 50%\">M\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft: suy t\u1ee7y, thi\u1ebfu m\u00e1u, thi\u1ebfu m\u00e1u b\u1ea5t s\u1ea3n, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p>Mi\u1ec5n d\u1ecbch: n\u1ed5i m\u1ec1 \u0111ay, ph\u00f9 m\u1ea1ch, co th\u1eaft ph\u1ebf qu\u1ea3n.<\/p>\n<p>TKTW: co gi\u1eadt, h\u1ed9i ch\u1ee9ng ngo\u1ea1i th\u00e1p.<\/p>\n<p>M\u1eaft: b\u1ec7nh ho\u00e0ng \u0111i\u1ec3m, tho\u00e1i h\u00f3a \u0111i\u1ec3m v\u00e0ng.<\/p>\n<p>Tai: m\u1ea5t kh\u1ea3 n\u0103ng nghe.<\/p>\n<p>C\u01a1 &#8211; x\u01b0\u01a1ng &#8211; kh\u1edbp: y\u1ebfu c\u01a1, teo c\u01a1, nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao h\u01a1n.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: t\u1ee5t \u0111\u01b0\u1eddng huy\u1ebft.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<h4>T\u01b0\u01a1ng t\u00e1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/h4>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng chung citalopram v\u1edbi c\u00e1c thu\u1ed1c thu\u1ed9c 1 trong nh\u1eefng nh\u00f3m sau:<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf monoamin oxydase<\/p>\n<p>Thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT<\/p>\n<p>Pimozid<\/p>\n<p>Selegilin (thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc monoamin oxydase B)<\/p>\n<h4>C\u00e10c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u1ea7n ch\u00fa \u00fd<\/h4>\n<p>Lithi v\u00e0 tryptophan: Th\u1ef1c hi\u1ec7n gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 lithi th\u01b0\u1eddng quy khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh k\u1ebft h\u1ee3p<\/p>\n<p>C\u00e1c ch\u1ea5t ch\u1ee7 v\u1eadn h\u1ec7 serotonergic: t\u0103ng c\u00e1c t\u00e1c d\u1ee5ng li\u00ean quan \u0111\u1ebfn serotonin<\/p>\n<p>Thu\u1ed1c c\u00f3 nguy c\u01a1 g\u00e2y xu\u1ea5t huy\u1ebft ( thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u; thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID), aspirin, dipyridamol v\u00e0 ticlopidin): t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft nghi\u00eam tr\u1ecdng.<\/p>\n<p>C\u00e1c thu\u1ed1c g\u00e2y h\u1ea1 kali huy\u1ebft, h\u1ea1 magnesi huy\u1ebft: t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp \u00e1c t\u00ednh.<\/p>\n<p>C\u00e1c thu\u1ed1c l\u00e0m gi\u1ea3m ng\u01b0\u1ee1ng co gi\u1eadt: Th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c: thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m thu\u1ed1c an th\u1ea7n kinh (thioxanthen v\u00e0 butyrophenon), mefloquin, bupropion v\u00e0 tramadol<\/p>\n<p>Cimetidin: l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u1ee7a citalopram<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf CYP 2C19: l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 citalopram trong m\u00e1u, xem x\u00e9t gi\u1ea3m li\u1ec1u c\u00e1c thu\u1ed1c n\u1ebfu b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n t\u00e1c d\u1ee5ng ph\u1ee5<\/p>\n<p>Thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP 2D6: Th\u1eadn tr\u1ecdng khi d\u00f9ng citalopram v\u1edbi c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a ch\u00ednh b\u1edfi enzym n\u00e0y nh\u01b0 flecainid, propafenon, Metoprolol (khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb suy tim), thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (desipramin, clomipramin v\u00e0 nortriptylin) ho\u1eb7c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n (risperidon, Thioridazin v\u00e0 haloperidol)<\/p>\n<p>Desipramin: n\u1ed3ng \u0111\u1ed9 desipramin trong m\u00e1u t\u0103ng l\u00ean khi c\u00f3 m\u1eb7t citalopram<\/p>\n<h3>L\u01b0u \u00fd khi d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Citalopram kh\u00f4ng n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai tr\u1eeb khi c\u1ea7n thi\u1ebft v\u00e0 ch\u1ec9 sau khi c\u00e2n nh\u1eafc k\u00ec l\u1ee3i \u00edch &#8211; nguy c\u01a1.<\/p>\n<p>Tr\u1ebb s\u01a1 sinh c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i n\u1ebfu ng\u01b0\u1eddi m\u1eb9 d\u00f9ng citalopram trong giai \u0111o\u1ea1n sau c\u1ee7a thai k\u1ef3, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong 3 th\u00e1ng cu\u1ed1i. Tr\u00e1nh ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t trong th\u1eddi gian mang thai v\u00ec tr\u1ebb s\u01a1 sinh c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i h\u1ed9i ch\u1ee9ng cai thu\u1ed1c.<\/p>\n<p>Tr\u1ebb s\u01a1 sinh khi b\u00fa s\u1ebd nh\u1eadn \u0111\u01b0\u1ee3c li\u1ec1u thu\u1ed1c kho\u1ea3ng 5% li\u1ec1u c\u1ee7a m\u1eb9 (t\u00ednh theo mg\/kg); do \u0111\u00f3 n\u1ebfu m\u1eb9 ph\u1ea3i s\u1eed d\u1ee5ng citalopram, ng\u1eebng cho con b\u00fa.<\/p>\n<h3>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ng\u01b0\u1eddi tr\u1ea7m c\u1ea3m, c\u00f3 ho\u1eb7c kh\u00f4ng \u0111i\u1ec1u tr\u1ecb v\u1edbi citalopram \u0111\u1ec1u kh\u00f4ng n\u00ean t\u1ef1 \u00fd l\u00e1i xe; hay th\u1ef1c hi\u1ec7n c\u00e1c thao t\u00e1c nguy hi\u1ec3m; c\u1ea7n t\u1eadp trung cao nh\u01b0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c thi\u1ebft b\u1ecb; l\u00e0m vi\u1ec7c tr\u00ean cao;&#8230;<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<h4>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u<\/h4>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng khi qu\u00e1 li\u1ec1u citalopram: co gi\u1eadt, nh\u1ecbp tim nhanh, bu\u1ed3n ng\u1ee7, co gi\u1eadt, k\u00e9o d\u00e0i kho\u1ea3ng QT, h\u00f4n m\u00ea, n\u00f4n, run, h\u1ea1 huy\u1ebft \u00e1p, ng\u1eebng tim, bu\u1ed3n n\u00f4n, h\u1ed9i ch\u1ee9ng serotonin, \u0111\u1ed5 m\u1ed3 h\u00f4i, k\u00edch \u0111\u1ed9ng, nh\u1ecbp tim ch\u1eadm, ch\u00f3ng m\u1eb7t, bl\u1ed1c nh\u00e1nh, k\u00e9o d\u00e0i QRS, t\u0103ng huy\u1ebft \u00e1p, gi\u00e3n \u0111\u1ed3ng t\u1eed, xo\u1eafn \u0111\u1ec9nh, \u0111\u1edd \u0111\u1eabn, \u0111\u1ed5 m\u1ed3 h\u00f4i, t\u00edm t\u00e1i, th\u1edf nhanh, th\u00e2n nhi\u1ec7t cao \u0111\u1ed9t ng\u1ed9t, r\u1ed1i lo\u1ea1n nh\u1ecbp nh\u0129, t\u00e2m th\u1ea5t; H\u1ed9i ch\u1ee9ng serotonin hi\u1ebfm khi x\u1ea3y ra<\/p>\n<p>Thay \u0111\u1ed5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 bao g\u1ed3m nh\u1ecbp xoang, kho\u1ea3ng QT k\u00e9o d\u00e0i v\u00e0 ph\u1ee9c h\u1ee3p QRS r\u1ed9ng c\u00f3 th\u1ec3 x\u1ea3y ra. Nh\u1ecbp tim ch\u1eadm k\u00e9o d\u00e0i, t\u1ee5t huy\u1ebft \u00e1p n\u1eb7ng v\u00e0 ng\u1ea5t c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o.<\/p>\n<h4>X\u1eed tr\u00ed:<\/h4>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho citalopram. \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 bao g\u1ed3m duy tr\u00ec \u0111\u01b0\u1eddng th\u1edf, theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed5 v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u sinh t\u1ed3n cho \u0111\u1ebfn khi b\u1ec7nh nh\u00e2n \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>C\u00e2n nh\u1eafc d\u00f9ng Than ho\u1ea1t t\u00ednh \u1edf ng\u01b0\u1eddi l\u1edbn ho\u1eb7c tr\u1ebb qu\u00e1 li\u1ec1u citalopram tr\u00ean 5 mg\/kg trong v\u00f2ng 1 gi\u1edd.0<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n n\u01a1i kh\u00f4 tho\u00e1ng, tr\u00e1nh \u00e1nh s\u00e1ng m\u1ea1nh, nhi\u1ec7t \u0111\u1ed9 duy tr\u00ec d\u01b0\u1edbi 30\u00b0C<\/p>\n<h2>Cinasav 10 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c Cinasav 10 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 Cinasav 10<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c nh\u01b0:<\/p>\n<ul>\n<li>.<a href=\"https:\/\/vnras.com\/drug\/bagocit-20\/\">Thu\u1ed1c Bagocit 20mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Citalopram, \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n trong \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m, c\u1ea7n s\u1eed d\u1ee5ng trong 32 tu\u1ea7n \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 t\u1ed1t; \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Laboratorios Bago S.A, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-16306-13.<\/li>\n<li><a href=\"https:\/\/vnras.com\/drug\/thuoc-eslo-10\/\">Thu\u1ed1c Eslo-10<\/a> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n Escitalopram 10mg; l\u00e0 thu\u1ed1c thu\u1ed9c c\u00f9ng nh\u00f3m thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc thu h\u1ed3i serotonin (SSRI); \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n tr\u1ea7m c\u1ea3m \u0111\u01a1n c\u1ef1c giai \u0111o\u1ea1n c\u1ea5p v\u00e0 duy tr\u00ec. Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Hetero Labs Limited \u2013 \u1ea4n \u0110\u1ed9, hi\u1ec7n c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-19472-15; h\u1ed9p 3 v\u1ec9 x 10 vi\u00ean c\u00f3 gi\u00e1 250.000 \u0111\u1ed3ng\/ h\u1ed9p.<\/li>\n<\/ul>\n<h2>T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn Cinasav 10?<\/h2>\n<table style=\"border-collapse: collapse;width: 100%;height: 149px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td style=\"width: 53.7694%;height: 21px;text-align: center\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 46.2306%;height: 21px;text-align: center\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr style=\"height: 86px\">\n<td style=\"width: 53.7694%;height: 86px\">Thu\u1ed1c Cinasav 10 l\u00e0 thu\u1ed1c c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n Citalopram; l\u00e0 li\u1ec7u ph\u00e1p th\u01b0\u1eddng xuy\u00ean \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi c\u01a1n tr\u1ea7m c\u1ea3m n\u1eb7ng v\u00e0 r\u1ea5t n\u1eb7ng.<\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ec1u \u1edf m\u1ee9c nh\u1eb9 v\u00e0 c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c; thu\u1ed1c \u00edt g\u00e2y c\u00e1c tri\u1ec7u ch\u1ee9ng ph\u1ee5 nghi\u00eam tr\u1ecdng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c.<\/p>\n<p>Citalopram hydrobromide l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu serotonin c\u00f3 ch\u1ecdn l\u1ecdc. Vi\u1ec7c s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng ch\u00ednh \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho citalopram hydrobromide l\u00e0 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng tr\u1ea7m c\u1ea3m \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n bao phim nh\u1ecf g\u1ecdn, d\u1ec5 d\u00e0ng s\u1eed d\u1ee5ng, che d\u1ea5u m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t, t\u00ednh \u1ed5n \u0111\u1ecbnh cao, thu\u1eadn ti\u00ean \u0111\u1ec3 mang theo, b\u1ea3o qu\u1ea3n.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n m\u1eafc tr\u1ea7m c\u1ea3m sau \u0111\u1ed9t qu\u1ef5, hi\u1ec7u qu\u1ea3 c\u1ee7a citalopram \u0111\u01b0\u1ee3c ch\u1ee9ng minh t\u01b0\u01a1ng t\u1ef1 nh\u01b0 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c SSRI v\u00e0 SNRI kh\u00e1c, nh\u01b0ng cho t\u00e1c d\u1ee5ng c\u1ea3i thi\u1ec7n nhanh h\u01a1n nhi\u1ec1u, \u0111\u1ed3ng th\u1eddi t\u00e1c d\u1ee5ng ph\u1ee5 x\u1ea3y ra \u1edf m\u1ee9c \u0111\u1ed9 r\u1ea5t nh\u1eb9 v\u00e0 t\u1ea7n su\u1ea5t c\u00f3 th\u1ec3 ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i d\u00e0i, thu\u1ed1c t\u1ed3n t\u1ea1i trong m\u00e1u trong th\u1eddi gian t\u01b0\u01a1ng \u0111\u1ed1i d\u00e0i, cho hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb duy tr\u00ec khi s\u1eed d\u1ee5ng 1 l\u1ea7n duy nh\u1ea5t m\u1ed7i ng\u00e0y.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1ec1 t\u00ednh an to\u00e0n c\u1ee7a thu\u1ed1c \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng, c\u00e1c d\u1ee5ng ph\u1ee5 v\u1ec1 th\u1ea7n kinh do s\u1eed d\u1ee5ng vitamin B l\u00e0 r\u1ea5t hi\u1ebfm; v\u00e0 ch\u1ec9 x\u1ea3y ra v\u1edbi ng\u01b0\u1eddi d\u00f9ng li\u1ec1u cao v\u00e0\/ho\u1eb7c th\u1eddi gian \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i.<\/p>\n<p>D\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1eeb c\u00f4ng ty d\u01b0\u1ee3c paharm Solupharm t\u1eeb \u0110\u1ee9c; chuy\u00ean cung c\u1ea5p c\u00e1c s\u1ea3n ph\u1ea9m ti\u00eam tuy\u1ec1n, thu\u1ed1c gi\u1ea3m \u0111au h\u00e0ng \u0111\u1ea7u t\u1ea1i \u0110\u1ee9c.<\/td>\n<td style=\"width: 46.2306%;height: 86px\">Thu\u1ed1c c\u00f3 t\u01b0\u01a1ng t\u00e1c ph\u1ee9c t\u1ea1p, c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ed1i v\u1edbi nhi\u1ec1u thu\u1ed1c \u0111i\u1ec1u tr\u1ecb hay d\u00f9ng, do \u0111\u00f3 vi\u1ec7c ch\u1ec9 \u0111\u1ecbnh v\u00e0 d\u00f9ng thu\u1ed1c c\u1ea7n h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng<\/p>\n<p>Do t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd ch\u00ednh c\u1ee7acitalopram l\u00e0 \u1ee9c ch\u1ebf t\u00e2m th\u1ea7n, c\u00f3 th\u1ec3 b\u1ecb l\u1ea1m d\u1ee5ng v\u00e0 s\u1eed d\u1ee5ng cho nh\u1eefng m\u1ee5c \u0111\u00edch kh\u00e1c ch\u1ec9 \u0111inh c\u1ee7a thu\u1ed1c, vi\u1ec7c mua b\u00e1n v\u00e0 s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c h\u01b0\u1edbng th\u1ea7n nh\u00ecn chung \u0111\u1ec1u c\u1ea7n qu\u1ea3n l\u00fd nghi\u00eam ng\u1eb7t v\u00e0 c\u1ee5 th\u1ec3.<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u00e1c gi\u1ea3: N G Parker, C S Brown (Ng\u00e0y \u0111\u0103ng: th\u00e1ng 6 n\u0103m 2020). Citalopram in the treatment of depression. Truy c\u1eadp ng\u00e0y 21 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10860138\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/10860138\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Min Cui, Chao Yun Huang v\u00e0 Fang Wang (Ng\u00e0y \u0111\u0103ng: th\u00e1ng 11 n\u0103m 2018).<em> Efficacy and Safety of Citalopram for the Treatment of Poststroke Depression: A Meta-Analysis.<\/em> Truy c\u1eadp ng\u00e0y 21 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30201459\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30201459\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Nazila Sharbaf Shoar (Ng\u00e0y \u0111\u0103ng ng\u00e0y 11 th\u00e1ng 12 n\u0103m 2021). <i>Citalopram. <\/i>Truy c\u1eadp ng\u00e0y 21 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29489221\/#:~:text=Citalopram%20hydrobromide%20is%20a%20selective,treatment%20of%20depression%20in%20adults\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29489221<\/a><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF t\u1ea1i \u0111\u00e2y.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Canasav 10 l\u00e0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m nh\u00f3m \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc t\u00e1i h\u1ea5p thu serotonin, h\u1ed9p 3 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim<\/p>\n","protected":false},"author":490,"featured_media":50513,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-50511","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/50511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=50511"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/50513"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=50511"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=50511"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=50511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}