{"id":49918,"date":"2023-10-18T23:20:50","date_gmt":"2023-10-18T16:20:50","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=49918"},"modified":"2025-07-24T14:00:10","modified_gmt":"2025-07-24T07:00:10","slug":"thuoc-vastanic-10","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-vastanic-10\/","title":{"rendered":"Vastanic 10"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n th\u00f4ng tin thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/thuoc-vastanic-10\/\">Vastanic 10<\/a> ch\u1ee9a ho\u1ea1t ch\u1ea5t lovastatin; l\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 h\u1ea1 cholesterol m\u00e1u; ng\u0103n ng\u1eeba h\u00ecnh th\u00e1nh c\u00e1c m\u1ea3ng x\u01a1 v\u1eefa v\u00e0 d\u1ef1 ph\u00f2ng b\u1ec7nh l\u00fd t\u1ea1i m\u1ea1ch v\u00e0nh. Thu\u1ed1c Vastanic 10 c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 VD-30090-18; do USA &#8211; NIC Pharma ch\u1ecbu tr\u00e1ch nhi\u1ec7m s\u1ea3n xu\u1ea5t, ph\u00e2n ph\u1ed1i.<\/b><\/p>\n<h2>Vastanic (Lovastatin) 10mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3><span style=\"font-weight: 400\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><span style=\"font-weight: 400\">Trong m\u1ed7i vi\u00ean thu\u1ed1c <strong>Vastanic 10 <\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Lovastatin h\u00e0m l\u01b0\u1ee3ng 10mg.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/span><\/p>\n<h3><span style=\"font-weight: 400\">Tr\u00ecnh b\u00e0y<\/span><\/h3>\n<p><span style=\"font-weight: 400\">S\u0110K: VD-30090-18.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u0110\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n<p><span style=\"font-weight: 400\">Xu\u1ea5t x\u1ee9: USA &#8211; NIC Pharma &#8211; Vi\u1ec7t Nam.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Vastanic 10 \u00a0<\/span><\/h2>\n<h3><span style=\"font-weight: 400\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p>Lovastatin l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc v\u00e0 c\u1ea1nh tranh v\u1edbi hydroxymethylglutaryl-coenzym A (HMG-CoA) reductase tai gan, l\u00e0 enzym x\u00fac t\u00e1c qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i HMG-CoA th\u00e0nh mevalonat, m\u1ed9t ti\u1ec1n ch\u1ea5t c\u1ee7a cholesterol. T\u00e1c d\u1ee5ng n\u00e0y l\u00e0m gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n, LDL v\u00e0 VLDL cholesterol.<\/p>\n<p>Th\u00f4ng qua c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng n\u00e0y, lovastatin l\u00e0m gi\u1ea3m LDL v\u00e0 VLDL trong huy\u1ebft t\u01b0\u01a1ng, gi\u1ea3m n\u1ed3ng \u0111\u1ed9 apolipoprotein B. B\u00ean c\u1ea1nh \u0111\u00f3, lovastatin c\u0169ng l\u00e0m t\u0103ng v\u1eeba ph\u1ea3i HDL v\u00e0 l\u00e0m gi\u1ea3m triglycerid.<\/p>\n<h3>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Thu\u1ed1c h\u1ea5p thu t\u1ea1i ru\u1ed9t non v\u00e0 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong m\u00e1u Tmax l\u00e0 3,36 gi\u1edd. N\u1ed3ng \u0111\u1ed9 h\u1ea5p thu c\u1ee7a thu\u1ed1c ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c t\u0103ng l\u00ean khi \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng th\u1ee9c \u0103n.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o v\u00e0 qua \u0111\u01b0\u1ee3c nhau thai do t\u00ednh \u01b0a m\u1ee1 c\u1ee7a lovastatin. C\u1ea3 lovastatin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a thu\u1ed1c l\u00e0 axit \u03b2-hydroxy \u0111\u1ec1u c\u00f3 t\u1ec9 l\u1ec7 li\u00ean k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (tr\u00ean 95%).<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Lovastatin l\u00e0 d\u1ea1ng ti\u1ec1n ch\u1ea5t lacton, ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c l\u00e0 beta-hydroxy. Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a t\u1ea1i gan b\u1edfi h\u1ec7 th\u1ed1ng enzym Cytochrom P-450 isoform 3A4.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Con \u0111\u01b0\u1eddng th\u1ea3i tr\u1eeb ch\u00ednh c\u1ee7a lovastatin l\u00e0 ph\u00e2n (83%), ph\u1ea7n nh\u1ecf kho\u1ea3ng 10% \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c kho\u1ea3ng 13,37 gi\u1edd<\/p>\n<h2><span style=\"font-weight: 400\">Thu\u1ed1c Vastanic 10 tr\u1ecb b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p>T\u0103ng cholesterol m\u00e1u: C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh b\u1ed5 tr\u1ee3 cho li\u1ec7u ph\u00e1p \u0103n u\u1ed1ng \u0111\u1ec3 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 cholesterol to\u00e0n ph\u1ea7n v\u00e0 cholesterol LDL \u1edf ng\u01b0\u1eddi b\u1ec7nh t\u0103ng cholesterol m\u00e1u ti\u00ean ph\u00e1t (typ IIa v\u00e0 IIb).<\/p>\n<p>D\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t (c\u1ea5p 1) bi\u1ebfn c\u1ed1 m\u1ea1ch v\u00e0nh: \u1ede ng\u01b0\u1eddi t\u0103ng cholesterol m\u00e1u m\u00e0 kh\u00f4ng c\u00f3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng r\u00f5 r\u1ec7t v\u1ec1 m\u1ea1ch v\u00e0nh, ch\u1ec9 \u0111\u1ecbnh c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase \u0111\u1ec3 gi\u1ea3m c\u00e1c nguy c\u01a1:<\/p>\n<ul>\n<li>Nh\u1ed3i m\u00e1u c\u01a1 tim.<\/li>\n<li>Ph\u1ea3i can thi\u1ec7p b\u1eb1ng c\u00e1c th\u1ee7 thu\u1eadt t\u00e1i t\u1ea1o m\u1ea1ch v\u00e0nh tim.<\/li>\n<li>Xu\u1ea5t hi\u1ec7n c\u01a1n \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh.<\/li>\n<\/ul>\n<p>D\u1ef1 ph\u00f2ng th\u1ee9 ph\u00e1t c\u00e1c bi\u1ebfn c\u1ed1 t\u1ea1i m\u1ea1ch v\u00e0nh.<\/p>\n<p>X\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch: \u1edf ng\u01b0\u1eddi b\u1ec7nh t\u0103ng cholesterol m\u00e1u c\u00f3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng v\u1ec1 b\u1ec7nh m\u1ea1ch v\u00e0nh, k\u1ec3 c\u1ea3 nh\u1ed3i m\u00e1u c\u01a1 tim tr\u01b0\u1edbc \u0111\u00f3, ch\u1ec9 \u0111\u1ecbnh c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase v\u1edbi m\u1ee5c \u0111\u00edch:<\/p>\n<ul>\n<li>L\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n x\u01a1 v\u1eefa m\u1ea1ch v\u00e0nh.<\/li>\n<li>Gi\u1ea3m nguy c\u01a1 xu\u1ea5t hi\u1ec7n bi\u1ebfn c\u1ed1 m\u1ea1ch v\u00e0nh c\u1ea5p t\u00ednh.<\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Li\u1ec1u d\u00f9ng &#8211; c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Vastanic 10 \u00a0<\/span><\/h2>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Tr\u01b0\u1edbc v\u00e0 trong qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c, ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n k\u1ebft h\u1ee3p v\u1edbi ch\u1ebf \u0111\u1ed9 \u0103n ti\u00eau chu\u1ea9n, h\u1ea1n ch\u1ebf cholesterol \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, d\u1ef1a v\u00e0o \u0111\u00e1p \u1ee9ng c\u1ee7a c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u ph\u00f9 h\u1ee3p theo t\u1eebng \u0111\u1ee3t, th\u1eddi gian t\u0103ng li\u1ec1u m\u1ed7i \u0111\u1ee3t kh\u00f4ng d\u01b0\u1edbi 4 tu\u1ea7n.<\/p>\n<p>S\u1eed d\u1ee5ng thu\u1ed1c v\u00e0o b\u1eefa \u0103n t\u1ed1i s\u1ebd gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c v\u00ec gan th\u1ef1c hi\u1ec7n qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p cholesterol v\u00e0o ban \u0111\u00eam.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c t\u0103ng l\u00ean khi k\u1ebft h\u1ee3p c\u00f9ng sequestrants acid m\u1eadt.<\/p>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Li\u1ec1u ban \u0111\u1ea7u: 20mg\/ng\u00e0y. Li\u1ec1u duy tr\u00ec l\u00e0 20 &#8211; 80mg.<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng li\u1ec1u tr\u00ean 20mg\/ng\u00e0y khi s\u1eed d\u1ee5ng c\u00f9ng c\u00e1c thu\u1ed1c Danazol, Verapamil ho\u1eb7c diltiazem.<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng li\u1ec1u tr\u00ean 40 mg\/ng\u00e0y khi s\u1eed d\u1ee5ng c\u00f9ng thu\u1ed1c amiodaron.<\/p>\n<p>B\u1ec7nh nh\u00e2n t\u1eeb 10 &#8211; 17 tu\u1ed5i b\u1ecb t\u0103ng cholesterol m\u00e1u di truy\u1ec1n: Li\u1ec1u 10 &#8211; 40mg\/ng\u00e0y, v\u00e0 li\u1ec1u t\u1ed1i \u0111a l\u00e0 40mg\/ng\u00e0y.<\/p>\n<p>B\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn n\u1eb7ng (\u0110\u1ed9 thanh th\u1ea3i creatinin d\u01b0\u1edbi 30 ml\/ph\u00fat) th\u00ec tr\u00e1nh d\u00f9ng li\u1ec1u qu\u00e1 20 mg\/ng\u00e0y.<\/p>\n<h2><span style=\"font-weight: 400\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Vastanic 10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p>Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi lovastatin, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase hay b\u1ea5t k\u00ec th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ecb b\u1ec7nh gan ho\u1ea1t \u0111\u1ed9ng hay transaminase trong m\u00e1u t\u0103ng dai d\u1eb3ng kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 \u0111ang cho con b\u00fa.<\/p>\n<p>Kh\u00f4ng d\u00f9ng lovastatin k\u1ebft h\u1ee3p c\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP 3A4 m\u1ea1nh (bao g\u1ed3m ketoconazol, itraconazol, posaconazol, Clarithromycin, Erythromycin, telithromycin)<\/p>\n<p>Kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf Protease c\u1ee7a HIV (bao g\u1ed3m boceprevir, telaprevir, nefazodon).<\/p>\n<p>Tuy\u1ec7t d\u1ed1i kh\u00f4ng s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi lovastatin v\u1edbi: Cyclosporin, gemfibrozil.<\/p>\n<p>Tr\u00e1nh d\u00f9ng l\u01b0\u1ee3ng l\u1edbn n\u01b0\u1edbc \u00e9p b\u01b0\u1edfi (&gt;1 l\u00edt\/ng\u00e0y)<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf HIV-protease: N\u1ed3ng \u0111\u1ed9 c\u1ee7a Sildenafil t\u0103ng \u0111\u00e1ng k\u1ec3 v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 Ritonavir<\/p>\n<p>N\u01b0\u1edbc b\u01b0\u1edfi: L\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Sildenafil n\u00ean tr\u00e1nh d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p>Kh\u00f4ng d\u00f9ng qu\u00e1 20mg lovastatin\/ng\u00e0y khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi danazol, diltiazem ho\u1eb7c verapamil.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi amiodaron.kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng qu\u00e1 40mg lovastatin m\u1ed7i ng\u00e0y.<\/p>\n<p>Lovastatin kh\u00f4ng \u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 ch\u1ee9a nh\u00f3m cobicistat<\/p>\n<h2><span style=\"font-weight: 400\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Vastanic 10 \u00a0<\/span><\/h2>\n<h3><span style=\"font-weight: 400\">Th\u1eadn tr\u1ecdng<\/span><\/h3>\n<p>M\u1ee5c ti\u00eau trong \u0111i\u1ec1u tr\u1ecb l\u00e0 gi\u1ea3m cholesterol LDL, do \u0111\u00f3 vi\u1ec7c s\u1eed d\u1ee5ng n\u1ed3ng \u0111\u1ed9 cholesterol ban \u0111\u1ea7u \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u00e0 theo d\u00f5i \u0111i\u1ec1u tr\u1ecb l\u00e0 r\u1ea5t c\u1ea7n thi\u1ebft. Tr\u1eeb tr\u01b0\u1eddng h\u1ee3p n\u1ed3ng \u0111\u1ed9 n\u00e0y kh\u00f4ng \u0111o \u0111\u01b0\u1ee3c th\u00ec s\u1ebd d\u1ef1a tr\u00ean cholesterol to\u00e0n ph\u1ea7n.<\/p>\n<p>M\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ec7nh g\u1eb7p t\u00ecnh tr\u1ea1ng t\u0103ng n\u1ed3ng \u0111\u1ed9 transaminase v\u00e0 tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng sau ng\u1eebng thu\u1ed1c.<\/p>\n<p>S\u1eed d\u1ee5ng thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng gan, do v\u1eady c\u1ea7n ti\u1ebfn h\u00e0nh x\u00e9t nghi\u1ec7m c\u00e1c ch\u1ec9 s\u1ed1 men gan tr\u01b0\u1edbc, trong v\u00e0 sau khi \u0111i\u1ec1u tr\u1ecb. C\u1ea7n th\u1eadn tr\u1ecdng tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n th\u01b0\u1eddng xuy\u00ean u\u1ed1ng r\u01b0\u1ee3u hay c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh gan tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 bi\u1ec3u hi\u1ec7n b\u1ecb b\u1ec7nh c\u01a1 c\u1ea5p n\u1eb7ng hay c\u00f3 nguy c\u01a1 b\u1ecb suy th\u1eadn c\u1ea5p do ti\u00eau c\u01a1 v\u00e2n th\u00ec c\u1ea7n ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng thu\u1ed1c tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh \u0111\u1ebb khi ch\u1eafc ch\u1eafn r\u1eb1ng h\u1ecd kh\u00f4ng c\u00f3 thai v\u00e0 trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p cholesterol m\u00e1u t\u0103ng r\u1ea5t cao.<\/p>\n<p>N\u00ean theo d\u00f5i ch\u1ec9 s\u1ed1 creatinin kinase (CK) t\u1ea1i c\u00e1c th\u1eddi \u0111i\u1ec3m l\u00e0 tr\u01b0\u1edbc v\u00e0 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng lovastatin.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c statin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao.<\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng c\u00e1c ch\u1ec9 s\u1ed1 phosphokinase creatine v\u00e0 transaminase, do \u0111\u00f3 n\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t khi ch\u1ea9n \u0111o\u00e1n ph\u00e2n bi\u1ec7t \u0111au ng\u1ef1c tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng lovastatin.<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c tr\u00ean b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n di truy\u1ec1n v\u1ec1 dung n\u1ea1p galactose, thi\u1ebfu h\u1ee5t lactase Lapp hay r\u1ed1i lo\u1ea1n h\u1ea5p thu Glucose &#8211; Gaclactose.<\/p>\n<h3><span style=\"font-weight: 400\">T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: \u1ec9a ch\u1ea3y, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng v\u00e0 bu\u1ed3n n\u00f4n, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd, m\u1ea5t ng\u1ee7, suy nh\u01b0\u1ee3c, \u0111au c\u01a1, \u0111au kh\u1edbp, men gan t\u0103ng cao v\u00e0 l\u1edbn h\u01a1n 3 l\u1ea7n gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>\u00cdt g\u1eb7p: b\u1ec7nh c\u01a1 (k\u1ebft h\u1ee3p y\u1ebfu c\u01a1 v\u00e0 t\u0103ng h\u00e0m l\u01b0\u1ee3ng creatinin phosphokinase huy\u1ebft t\u01b0\u01a1ng (CPK). Ban da, vi\u00eam m\u0169i, vi\u00eam xoang, vi\u00eam h\u1ecdng, ho.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: vi\u00eam c\u01a1, ti\u00eau c\u01a1 v\u00e2n, d\u1eabn \u0111\u1ebfn suy th\u1eadn c\u1ea5p th\u1ee9 ph\u00e1t do myoglobin ni\u1ec7u; Suy gi\u1ea3m nh\u1eadn th\u1ee9c; t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft v\u00e0\/ ho\u1eb7c c\u00f3 t\u0103ng HbA1c.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng ph\u1ee5 x\u1ea3y ra ph\u1ea7n l\u1edbn l\u00e0 kh\u00f4ng \u0111\u1ec3 l\u1ea1i bi\u1ebfn ch\u1ee9ng v\u00e0 t\u1ef1 h\u1ed3i ph\u1ee5c khi ng\u1eebng thu\u1ed1c.<\/p>\n<h3><span style=\"font-weight: 400\">T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n<p>Lovastatin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a warfarin.<\/p>\n<p>C\u00e1c nh\u1ef1a g\u1eafn acid m\u1eadt c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m r\u00f5 r\u1ec7t kh\u1ea3 d\u1ee5ng sinh h\u1ecdc c\u1ee7a lovastatin khi u\u1ed1ng c\u00f9ng. V\u00ec v\u1eady th\u1eddi gian d\u00f9ng 2 thu\u1ed1c n\u00e0y ph\u1ea3i c\u00e1ch xa nhau.<\/p>\n<p>Nh\u00f3m ACEI ph\u1ed1i h\u1ee3p v\u1edbi lovastatin: Ng\u0103n ng\u1eeba c\u00e1c bi\u1ebfn ch\u1ee9ng \u1edf tim tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim ha b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng tr\u00ean 55 tu\u1ed5i.<\/p>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 ( bao g\u1ed3m ketoconazol, itraconazol, voriconazol, posaconazol, clarithromycin, erythromycin, telithromycin) v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf protease c\u1ee7a HIV (bao g\u1ed3m boceprevir, telaprevir, nefazodon): t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh tr\u00ean c\u01a1 c\u1ee7a lovastatin.<\/p>\n<p>Gemfibrozil, c\u00e1c thu\u1ed1c h\u1ea1 cholesterol m\u00e1u nh\u00f3m fibrat kh\u00e1c, niacin li\u1ec1u cao (&gt;1g\/ng\u00e0y), colchicin: t\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng c\u01a1<\/p>\n<p>Cyclosporin, amiodaron, colchicin, ranolazin; Danazol, diltiazem, verapamil: t\u0103ng nguy c\u01a1 ti\u00eau v\u00e2n\/ t\u1ed5n th\u01b0\u01a1ng c\u01a1<\/p>\n<p>Acid fusidic: c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd do nguy c\u01a1 m\u1eafc b\u1ec7nh t\u1ea1i c\u01a1 c\u00f3 th\u1ec3 t\u0103ng l\u00ean. Khi ph\u1ea3i \u0111i\u1ec1u tr\u1ecb b\u1eaft bu\u1ed9c v\u1edbi Acid fusidic, c\u00f3 th\u1ec3 xem x\u00e9t ng\u01b0ng d\u00f9ng t\u1ea1m th\u1eddi lovastatin ho\u1eb7c chuy\u1ec3n sang li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c.<\/p>\n<h3>S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/p>\n<h3><span style=\"font-weight: 400\">\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y\u00a0<\/span><\/h3>\n<p>Thu\u1ed1c Vastanic 10 c\u00f3 th\u1ec3 g\u00e2y n\u00ean c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd. Do \u0111\u00f3 n\u00ean th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3><span style=\"font-weight: 400\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<p>Ch\u01b0a c\u00f3 b\u00e1o c\u00e1o v\u1ec1 qu\u00e1 li\u1ec1u g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng c\u1ea7n can thi\u1ec7p y t\u1ebf \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi d\u00f9ng<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u00fang ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129; tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng t\u1ef1 \u00fd t\u0103ng li\u1ec1u hay s\u1eed d\u1ee5ng v\u00e0o c\u00e1c m\u1ee5c \u0111\u00edch ngo\u00e0i \u0111i\u1ec1u tri<\/p>\n<h2><span style=\"font-weight: 400\">Thu\u1ed1c <\/span>Vastanic 10 gi\u00e1 bao nhi\u00eau<span style=\"font-weight: 400\">? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Thu\u1ed1c Vastanic (Lovastatin) 10mg gi\u00e1 bao nhi\u00eau? Thu\u1ed1c<\/span> Vastanic 10 <span style=\"font-weight: 400\"> hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Vastanic 10<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c thu\u1ed1c statin kh\u00e1c nh\u01b0:\u00a0\u00a0<\/span><\/p>\n<ul>\n<li><a href=\"https:\/\/vnras.com\/drug\/torvazin\/\">Thu\u1ed1c Torvazin<\/a> thu\u1ed9c nh\u00f3m thu\u1ed1c h\u1ea1 lipoprotein m\u00e1u v\u1edbi th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 Atorvastatin h\u00e0m l\u01b0\u1ee3ng 10mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty D\u01b0\u1ee3c ph\u1ea9m Egis \u2013 Hungary. Thu\u1ed1c hi\u1ec7n \u0111ang c\u00f3 gi\u00e1 125 000 VN\u0110 h\u1ed9p 30 vi\u00ean.<\/li>\n<li><a href=\"https:\/\/vnras.com\/drug\/rosuvas-hasan-5\/\">Thu\u1ed1c Rosuvas Hasan 5<\/a> l\u00e0 thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a m\u1ee1 m\u00e1u t\u1ef1 nhi\u00ean c\u00f3 hay b\u1edfi di truy\u1ec1n trong gia \u0111\u00ecnh v\u1edbi h\u00e0m l\u01b0\u1ee3ng 5 mg,th\u00e0nh ph\u1ea7n l\u00e0 Rosuvastatin; h\u1ed9p 3 v\u1ec9, m\u1ed7i v\u1ec9 c\u00f3 10 vi\u00ean c\u1ee7a C\u00f4ng ty TNHH li\u00ean doanh Hasan-Dermapharm. Thu\u1ed1c hi\u1ec7n c\u00f3 gi\u00e1 78000 \u0111\u1ed3ng m\u1ed9t h\u1ed9p.<\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Thu\u1ed1c Vastanic 10 c\u00f3 t\u1ed1t kh\u00f4ng?<\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td style=\"text-align: center\"><span style=\"font-weight: 400\">\u01afu \u0111i\u1ec3m<\/span><\/td>\n<td style=\"text-align: center\"><span style=\"font-weight: 400\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/span><\/td>\n<\/tr>\n<tr>\n<td>\n<ul>\n<li>Lovastatin c\u00f3 hi\u1ec7u qu\u1ea3 cao trong \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u nguy\u00ean ph\u00e1t v\u00e0 l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>C\u00e1c nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng, lovastatin c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 trong nhi\u1ec1u lo\u1ea1i ung th\u01b0 (nh\u01b0 ung th\u01b0 v\u00fa, gan, c\u1ed5 t\u1eed cung, ph\u1ed5i v\u00e0 ru\u1ed9t k\u1ebft). \u0110\u1ed3ng th\u1eddi, lovastatin c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a m\u1ed9t s\u1ed1 lo\u1ea1i t\u1ebf b\u00e0o ung th\u01b0 \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c h\u00f3a tr\u1ecb li\u1ec7u v\u00e0 t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a ch\u00fang.<\/li>\n<li>Lovastatin hi\u1ec7u qu\u1ea3 h\u01a1n trong vi\u1ec7c gi\u1ea3m n\u1ed3ng \u0111\u1ed9 cholesterol LDL, trong khi niacin hi\u1ec7u qu\u1ea3 h\u01a1n trong vi\u1ec7c t\u0103ng n\u1ed3ng \u0111\u1ed9 cholesterol lipoprotein m\u1eadt \u0111\u1ed9 cao v\u00e0 gi\u1ea3m m\u1ee9c lipoprotein Lp(a). Lovastatin \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t h\u01a1n niacin, ph\u1ea7n l\u1edbn l\u00e0 do c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn tr\u00ean da c\u1ee7a niacin.<\/li>\n<li>Thu\u1ed1c Vastanic 10 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n, nh\u1ecf g\u1ecdn s\u1eed d\u1ee5ng d\u1ec5 d\u00e0ng v\u00e0 thu\u1eadn ti\u1ec7n<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400\">Thu\u1ed1c g\u00e2y n\u00ean c\u00e1c r\u1ed1i lo\u1ea1n, \u0111\u1eb7c bi\u1ec7t tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<li>Lovastatin t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u nh\u00f3m thu\u1ed1c c\u0169ng nh\u01b0 c\u00e1c nguy c\u01a1 \u0111\u1ed9c t\u00ednh ti\u1ec1m t\u00e0ng<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">T\u00e1c gi\u1ea3 Liguo Xie v\u00e0 c\u1ed9ng s\u1ef1 (\u0110\u0103ng ng\u00e0y: 24 th\u00e1ng 8 n\u0103m 2021), <em>An overview on the biological activity and anti-cancer mechanism of lovastatin<\/em>. Truy c\u1eadp ng\u00e0y 18 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34438015\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34438015\/<\/a><\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">T\u00e1c gi\u1ea3 D R Illingworth v\u00e0 c\u1ed9ng s\u1ef1 (\u0110\u0103ng ng\u00e0y 25 th\u00e1ng 7 n\u0103m 1994).<em> Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial.<\/em>Truy c\u1eadp ng\u00e0y 18 th\u00e1ng 10 n\u0103m 2023 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8031206\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/8031206\/<\/a><\/span><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c Vastanic 10 do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2023\/10\/thuoc-vastanic-10-hdsd-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Vastanic 10 ch\u1ee9a lovastatin h\u00e0m l\u01b0\u1ee3ng 10mg; \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u v\u00e0 ng\u0103n ng\u1eeba c\u00e1c b\u1ec7nh m\u1ea1ch v\u00e0nh<\/p>\n","protected":false},"author":490,"featured_media":49919,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-49918","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/49918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=49918"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/49919"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=49918"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=49918"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=49918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}