{"id":48781,"date":"2023-10-14T15:08:44","date_gmt":"2023-10-14T08:08:44","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=48781"},"modified":"2025-07-24T14:01:47","modified_gmt":"2025-07-24T07:01:47","slug":"difelene","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/difelene\/","title":{"rendered":"Difelene"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Difelene<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Thai Nakorn Patana Vi\u1ec7t Nam, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-28618-17<\/strong><\/p>\n

Difelene l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Th\u00e0nh ph\u1ea7n<\/h3>\n
M\u1ed7i vi\u00ean Difelene c\u00f3 ch\u1ee9a:<\/p>\n
\n
Ho\u1ea1t ch\u1ea5t:\u00a0 Natri Diclofenac 50mg.<\/li>\n
T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n
Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: VD-28618-17.
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 10 vi\u00ean.
\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n
Thu\u1ed1c Difelene c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
Diclofenac l\u00e0 d\u1eabn xu\u1ea5t c\u1ee7a acid phenylacetic, thu\u1ed9c nh\u00f3m ch\u1ed1ng vi\u00eam kh\u00f4ng steroid v\u1edbi t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam, h\u1ea1 s\u1ed1t m\u1ea1nh. Diclofenac ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf m\u1ea1nh cyclooxygenase, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m t\u1ea1o th\u00e0nh nh\u1eefng ch\u1ea5t trung gian c\u1ee7a qu\u00e1 tr\u00ecnh vi\u00eam l\u00e0 prostaglandin, prostacyclin v\u00e0 thromboxan.<\/p>\n
Diclofenac c\u00f2n \u0111i\u1ec1u h\u00f2a con \u0111\u01b0\u1eddng lipoxygenase v\u00e0 s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u.<\/p>\n
Diclofenac g\u00e2y h\u1ea1i \u0111\u01b0\u1eddng ti\u00eau h\u00f3a do l\u00e0m gi\u1ea3m t\u1ed5ng h\u1ee3p prostaglandin, \u1ee9c ch\u1ebf t\u1ea1o mucin – ch\u1ea5t b\u1ea3o v\u1ec7 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n
Ngo\u00e0i ra, vi\u1ec7c \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin c\u00f3 th\u1ec3 g\u00e2y vi\u00eam th\u1eadn k\u1ebd, ho\u1ea1i t\u1eed nh\u00fa, vi\u00eam c\u1ea7u th\u1eadn v\u00e0 h\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0 \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng ng\u01b0\u1eddi b\u1ecb b\u1ec7nh th\u1eadn ho\u1eb7c suy tim m\u1ea1n t\u00ednh do prostaglandin c\u00f3 vai tr\u00f2 duy tr\u00ec t\u01b0\u1edbi m\u00e1u th\u1eadn.<\/p>\n
D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
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H\u1ea5p thu<\/li>\n<\/ul>\n
Sau khi u\u1ed1ng, Diclofenac \u0111\u01b0\u1ee3c h\u1ea5p th\u1ee5 d\u1ec5 d\u00e0ng qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Sau u\u1ed1ng 60-120 ph\u00fat, b\u1eaft \u0111\u1ea7u xu\u1ea5t hi\u1ec7n t\u00e1c d\u1ee5ng. N\u1ebfu u\u1ed1ng l\u00fac \u0111\u00f3i, thu\u1ed1c s\u1ebd h\u1ea5p th\u1ee5 nhanh h\u01a1n.
\nSinh kh\u1ea3 d\u1ee5ng trong m\u00e1u tu\u1ea7n ho\u00e0n g\u1ea7n b\u1eb1ng m\u1ed9t n\u1eeda sinh kh\u1ea3 d\u1ee5ng c\u1ee7a li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch.
\n2 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng. Sau khi u\u1ed1ng t\u1eeb 4 \u0111\u1ebfn 6 gi\u1edd, n\u1ed3ng \u0111\u1ed9 trong d\u1ecbch bao ho\u1ea1t d\u1ecbch \u0111\u1ea1t m\u1ee9c cao nh\u1ea5t.<\/p>\n
\n
Ph\u00e2n b\u1ed1<\/li>\n<\/ul>\n
Kh\u1ea3 n\u0103ng g\u1eafn c\u1ee7a Diclofenac v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u0111\u1eb7c bi\u1ec7t l\u00e0 albumin cao (99%).<\/p>\n
\n
Chuy\u1ec3n h\u00f3a<\/li>\n<\/ul>\n
\u00bd li\u1ec1u u\u1ed1ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan l\u1ea7n \u0111\u1ea7u.<\/p>\n
\n
Th\u1ea3i tr\u1eeb<\/li>\n<\/ul>\n
Kho\u1ea3ng 60% li\u1ec1u d\u00f9ng d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f2n m\u1ed9t ph\u1ea7n ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c th\u1ea3i qua th\u1eadn v\u00e0 d\u01b0\u1edbi 1 % \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n, c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb qua m\u1eadt v\u00e0 ph\u00e2n.<\/p>\n
Thu\u1ed1c Difelene \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
\u0110i\u1ec1u tr\u1ecb vi\u00eam v\u00e0 t\u00ecnh tr\u1ea1ng tho\u00e1i ho\u00e1 kh\u1edbp, vi\u00eam \u0111\u1ed1t s\u1ed1ng c\u1ee9ng kh\u1edbp, th\u1ea5p kh\u1edbp v\u00e0 vi\u00eam x\u01b0\u01a1ng kh\u1edbp m\u1ea1n t\u00ednh.<\/p>\n
L\u00e0m gi\u1ea3m \u0111au do vi\u00eam kh\u00f4ng ph\u1ea3i do th\u1ea5p kh\u1edbp.<\/p>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Difelene<\/h2>\n
U\u1ed1ng 1 vi\u00ean\/ l\u1ea7n x 2-3 l\u1ea7n\/ ng\u00e0y. U\u1ed1ng sau \u0103n ho\u1eb7c theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/p>\n
– Tho\u00e1i h\u00f3a kh\u1edbp: 1 vi\u00ean\/l\u1ea7n x 3 l\u1ea7n\/ng\u00e0y. \u0110i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i: 1 vi\u00ean\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n
– Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (th\u1ea5p kh\u1edbp): 2-4 vi\u00ean\/ng\u00e0y, chia th\u00e0nh nhi\u1ec1u l\u1ea7n. U\u1ed1ng kh\u00f4ng qu\u00e1 4 vi\u00ean\/ng\u00e0y. \u0110i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i: 1 vi\u00ean\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n
– Vi\u00eam \u0111\u1ed1t s\u1ed1ng c\u1ee9ng kh\u1edbp: u\u1ed1ng 1 vi\u00ean\/l\u1ea7n x 2 – 3 l\u1ea7n\/ng\u00e0y.<\/p>\n
– Gi\u1ea3m \u0111au: 1 vi\u00ean\/l\u1ea7n x 3 l\u1ea7n\/ng\u00e0y.<\/p>\n
– Gi\u1ea3m \u0111au trong ung th\u01b0: 2 vi\u00ean\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n
S\u1eed d\u1ee5ng li\u1ec1u h\u00e0ng ng\u00e0y th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3 \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 x\u1ea3y ra b\u1ea5t l\u1ee3i.<\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Difelene trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
– Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid v\u00e0 b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n
– B\u1ec7nh hen, co th\u1eaft ph\u1ebf qu\u1ea3n, b\u1ec7nh tim m\u1ea1ch, ch\u1ea3y m\u00e1u, suy gan n\u1eb7ng suy th\u1eadn n\u1eb7ng.<\/p>\n
– Lo\u00e9t d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n.<\/p>\n
– B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng Coumarin.<\/p>\n
– Ng\u01b0\u1eddi \u0111eo k\u00ednh s\u00e1t tr\u00f2ng.<\/p>\n
– Tr\u1ebb em < 12 tu\u1ed5i.<\/p>\n
– Ng\u01b0\u1eddi b\u1ecb gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n, t\u1ed1c \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn < 30 ml\/ph\u00fat.<\/p>\n
– Ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ch\u1ea5t t\u1ea1o keo.<\/p>\n
– B\u1ec7nh nh\u00e2n suy tim sung huy\u1ebft \u0111\u1ed9 II \u0111\u1ebfn \u0111\u1ed9 IV, b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch ngo\u1ea1i vi, b\u1ec7nh tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o.<\/p>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Difelene<\/h2>\n
Th\u1eadn tr\u1ecdng<\/h3>\n
C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c trong\u00a0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau \u0111\u00e2y:<\/p>\n
– Ng\u01b0\u1eddi c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a: ti\u1ec1n s\u1eed lo\u00e9t, ch\u1ea3y m\u00e1u ho\u1eb7c th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n
– Ng\u01b0\u1eddi b\u1ec7nh suy gan, suy th\u1eadn, lupus ban \u0111\u1ecf to\u00e0n th\u00e2n.<\/p>\n
– T\u0103ng huy\u1ebft \u00e1p hay b\u1ec7nh tim k\u00e8m \u1ee9 n\u01b0\u1edbc ho\u1eb7c ph\u00f9.<\/p>\n
– Ti\u1ec1n s\u1eed b\u1ec7nh gan. Khi \u0111i\u1ec1u tr\u1ecb d\u00e0i ng\u00e0y b\u1eb1ng diclofenac c\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng gan \u0111\u1ecbnh k\u1ef3.<\/p>\n
– B\u1ec7nh nh\u00e2n nhi\u1ec5m khu\u1ea9n.<\/p>\n
– Ng\u01b0\u1eddi b\u1ecb r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u, ch\u1ea3y m\u00e1u.<\/p>\n
– D\u00f9ng diclofenac c\u00f3 th\u1ec3 g\u00e2y r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, c\u1ea7n kh\u00e1m nh\u00e3n khoa<\/p>\n
C\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAIDs) l\u00e0m t\u0103ng nguy c\u01a1 huy\u1ebft kh\u1ed1i tim m\u1ea1ch bao g\u1ed3m nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 \u0111\u1ed9t qu\u1ef5, n\u1eb7ng c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong, ch\u1ee7 y\u1ebfu xu\u1ea5t hi\u1ec7n \u1edf li\u1ec1u cao.<\/p>\n
C\u1ea7n \u0111\u00e1nh gi\u00e1 \u0111\u1ecbnh k\u1ef3 s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch. C\u1ea3nh b\u00e1o cho b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u00e0 th\u0103m kh\u00e1m n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y.<\/p>\n
S\u1eed d\u1ee5ng li\u1ec1u h\u00e0ng ng\u00e0y th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3 \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 x\u1ea3y ra b\u1ea5t l\u1ee3i.<\/p>\n
B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 xu\u1ea5t hi\u1ec7n c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch (nh\u01b0 t\u0103ng huy\u1ebft \u00e1p, t\u0103ng lipid huy\u1ebft thanh, nghi\u1ec7n thu\u1ed1c l\u00e1, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng) c\u1ea7n c\u00e2n nh\u1eafc khi s\u1eed d\u1ee5ng diclofenac.<\/p>\n
T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c Difelene<\/h3>\n
S\u1eed d\u1ee5ng diclofenac c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i tim m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t \u1edf li\u1ec1u cao (150 mg\/ng\u00e0y) v\u00e0 k\u00e9o d\u00e0i.<\/p>\n\n\n\n\n\n\n\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/td>\n Bi\u1ec3u hi\u1ec7n<\/td>\n<\/tr>\n
Th\u01b0\u1eddng g\u1eb7p<\/td>\n Nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au v\u00f9ng th\u01b0\u1ee3ng v\u1ecb, b\u1ed3n ch\u1ed3n, ti\u00eau ch\u1ea3y, ch\u01b0\u1edbng b\u1ee5ng, kh\u00f3 ti\u00eau, ch\u00e1n \u0103n, t\u0103ng c\u00e1c transaminase, \u00f9 tai.<\/td>\n<\/tr>\n
\u00cdt g\u1eb7p<\/td>\n Ph\u00f9, vi\u00eam m\u0169i, d\u1ecb \u1ee9ng, cho\u00e1ng ph\u1ea3n v\u1ec7 k\u1ec3 c\u1ea3 t\u1ee5t huy\u1ebft \u00e1p, m\u00e0y \u0111ay.<\/td>\n<\/tr>\n
\u0110au b\u1ee5ng, lo\u00e9t ti\u1ebfn tri\u1ec3n, ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/td>\n<\/tr>\n
M\u1ea5t ng\u1ee7, m\u1ea5t th\u0103ng b\u1eb1ng, d\u1ec5 b\u1ecb k\u00edch th\u00edch, hoa m\u1eaft, ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n th\u00ednh gi\u00e1c nh\u1eb9, tr\u1ea7m c\u1ea3m, ng\u1ee9a, ng\u1ee7 g\u00e0, nh\u00ecn m\u1edd.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u01b0\u01a1ng t\u00e1c<\/h3>\n
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Diclofenac kh\u00f4ng n\u00ean ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c sau:<\/li>\n<\/ul>\n
– Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 heparin: v\u00ec c\u00f3 th\u1ec3 g\u00e2y xu\u1ea5t huy\u1ebft n\u1eb7ng.<\/p>\n
– Kh\u00e1ng sinh nh\u00f3m quinolon: diclofenac c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5 l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a nh\u00f3m thu\u1ed1c n\u00e0y.<\/p>\n
– Aspirin ho\u1eb7c Glucocorticoid: n\u1ed3ng \u0111\u1ed9 diclofenac trong huy\u1ebft t\u01b0\u01a1ng b\u1ecb gi\u1ea3m khi d\u00f9ng c\u00f9ng, \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean ti\u00eau h\u00f3a (ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y-ru\u1ed9t).<\/p>\n
– Diflunisal: n\u1ed3ng \u0111\u1ed9 diclofenac trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 t\u0103ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi, c\u00f3 th\u1ec3 g\u00e2y ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n
– Lithium: n\u1ed3ng \u0111\u1ed9 lithi trong huy\u1ebft thanh t\u0103ng khi d\u00f9ng c\u00f9ng diclofenac, g\u00e2y \u0111\u1ed9c. Tr\u01b0\u1eddng h\u1ee3p ph\u1ea3i d\u00f9ng \u0111\u1ed3ng th\u1eddi th\u00ec c\u1ea7n theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh c\u1ea9n th\u1eadn, theo d\u00f5i n\u1ed3ng \u0111\u1ed9 lith\u1ecb trong m\u00e1u th\u01b0\u1eddng xuy\u00ean. Trong v\u00e0 sau \u0111i\u1ec1u tr\u1ecb b\u1eb1ng diclofenac, ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u lithi.<\/p>\n
– Digoxin: n\u1ed3ng \u0111\u1ed9 digoxin trong huy\u1ebft thanh t\u0103ng, th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i khi d\u00f9ng c\u00f9ng diclofenac. N\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u1ea3 2 thu\u1ed1c \u0111\u1ecbnh l\u01b0\u1ee3ng n\u1ed3ng \u0111\u1ed9 digoxin trong m\u00e1u v\u00e0 gi\u1ea3m li\u1ec1u digoxin.<\/p>\n
– Ticlopidin: t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u khi d\u00f9ng c\u00f9ng diclofenac.<\/p>\n
– D\u1ee5ng c\u1ee5 tr\u00e1nh thai \u0111\u1eb7t trong t\u1eed cung: diclofenac c\u00f3 th\u1ec3 l\u00e0m m\u1ea5t t\u00e1c d\u1ee5ng tr\u00e1nh thai.<\/p>\n
– Methotrexat: \u0111\u1ed9c t\u00ednh c\u1ee7a methotrexat trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 t\u0103ng d\u1eabn \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng nhi\u1ec5m \u0111\u1ed9c.<\/p>\n
\n
C\u00f3 th\u1ec3 d\u00f9ng diclofenac c\u00f9ng c\u00e1c thu\u1ed1c sau k\u1ebft h\u1ee3p v\u1edbi theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh<\/li>\n<\/ul>\n
– Cyclosporin: c\u00f3 th\u1ec3 x\u1ea3y ra ng\u1ed9 \u0111\u1ed9c cyclosporin. Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean ch\u1ee9c n\u0103ng th\u1eadn c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n
– Thu\u1ed1c l\u1ee3i ni\u1ec7u: c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 suy th\u1eadn th\u1ee9 ph\u00e1t khi d\u00f9ng c\u00f9ng diclofenac.<\/p>\n
– Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p (thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n \u0111\u1ed5i, thu\u1ed1c ch\u1eb9n beta, thu\u1ed1c l\u1ee3i ni\u1ec7u).<\/p>\n
– D\u00f9ng thu\u1ed1c ch\u1ed1ng toan c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 diclofenac huy\u1ebft thanh.<\/p>\n
– Cimetidine c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nh\u1eb9 n\u1ed3ng \u0111\u1ed9 diclofenac huy\u1ebft thanh nh\u01b0ng t\u00e1c d\u1ee5ng c\u1ee7a ch\u1ed1ng vi\u00eam c\u1ee7a diclofenac kh\u00f4ng thay \u0111\u1ed5i.<\/p>\n
– Cimetidine gi\u00fap b\u1ea3o v\u1ec7 t\u00e1 tr\u00e0ng kh\u1ecfi t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i c\u1ee7a diclofenac.<\/p>\n
– Probenecid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng 2 l\u1ea7n n\u1ed3ng \u0111\u1ed9 diclofenac, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 t\u1ed1t \u1edf ng\u01b0\u1eddi b\u1ecb b\u1ec7nh kh\u1edbp nh\u01b0ng l\u1ea1i c\u00f3 th\u1ec3 x\u1ea3y ra ng\u1ed9 \u0111\u1ed9c diclofenac, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng ng\u01b0\u1eddi ch\u1ee9c n\u0103ng th\u1eadn gi\u1ea3m. Vi\u1ec7c th\u1ea3i acid uric-ni\u1ec7u kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng. Gi\u1ea3m li\u1ec1u diclofenac n\u1ebfu c\u1ea7n.<\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/h3>\n
\n
Ph\u1ee5 n\u1eef mang thai<\/li>\n<\/ul>\n
Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c cho ph\u1ee5 n\u1eef mang thai, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong 3 th\u00e1ng cu\u1ed1i thai k\u1ef3.<\/p>\n
\n
Ph\u1ee5 n\u1eef cho con b\u00fa<\/li>\n<\/ul>\n
Diclofenac c\u00f3 th\u1ec3 qua \u0111\u01b0\u1ee3c s\u1eefa m\u1eb9, ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c tr\u00ean tr\u1ebb b\u00fa m\u1eb9. C\u00f3 th\u1ec3 s\u1eed d\u1ee5ng thu\u1ed1c cho ph\u1ee5 n\u1eef cho con b\u00fa n\u1ebfu c\u1ea7n thi\u1ebft.<\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n
Qu\u00e1 li\u1ec1u x\u1ea3y ra v\u1edbi bi\u1ec3u hi\u1ec7n ch\u1ee7 y\u1ebfu l\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u1eb7ng l\u00ean.<\/p>\n
X\u1eed tr\u00ed: G\u00e2y n\u00f4n, r\u1eeda d\u1ea1 d\u00e0y k\u1ebft h\u1ee3p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 d\u00f9ng bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3. C\u00f3 th\u1ec3 d\u00f9ng than ho\u1ea1t, g\u00e2y l\u1ee3i ti\u1ec3u c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i nh\u01b0ng ph\u1ea3i theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e2n b\u1eb1ng n\u01b0\u1edbc-\u0111i\u1ec7n gi\u1ea3i khi d\u00f9ng.<\/p>\n
T\u00e1c \u0111\u1ed9ng tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n
Kh\u00f4ng c\u00f3 b\u00e1o c\u00e1o v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n
Thu\u1ed1c Difelene gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n
Thu\u1ed1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Difelene<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n
K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n
Thu\u1ed1c Refalax 20g<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n TRAPHACO, ch\u1ee9a Diclofenac natri 200mg. Thu\u1ed1c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb ch\u1ea5n th\u01b0\u01a1ng \u1edf g\u00e2n c\u01a1 v\u00e0 kh\u1edbp, ch\u1ea5n th\u01b0\u01a1ng v\u00f9ng d\u00e2y ch\u1eb1ng, vi\u00eam quanh kh\u1edbp hay vi\u00eam bao ho\u1ea1t d\u1ecbch, vi\u00eam c\u01a1. Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng gel b\u00f4i da. Li\u1ec1u d\u00f9ng ban \u0111\u1ea7u cho ng\u01b0\u1eddi tr\u00ean 12 tu\u1ed5i l\u00e0 b\u00f4i 2 \u2013 4 g\/l\u1ea7n x 3-4 l\u1ea7n\/ng\u00e0y. Thu\u1ed1c c\u00f3 gi\u00e1 kho\u1ea3ng 42.000 \u0111\u1ed3ng\/ 1 tu\u00fdp x 20 g.<\/p>\n
Thu\u1ed1c Voltaren SR<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m \u0111a qu\u1ed1c gia Novartis, ch\u1ee9a Diclofenac Na 75mg. Thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 c\u00e1c d\u1ea1ng tho\u00e1i h\u00f3a c\u1ee7a b\u1ec7nh th\u1ea5p kh\u1edbp, kh\u1eafc ph\u1ee5c t\u00ecnh tr\u1ea1ng \u0111au nh\u1ee9c, s\u01b0ng t\u1ea5y sau ph\u1eabu thu\u1eadt, \u0111i\u1ec1u tr\u1ecb vi\u00eam, \u0111au trong ph\u1ee5 khoa v\u00e0 h\u1ed7 tr\u1ee3 trong nhi\u1ec5m tr\u00f9ng tai m\u0169i h\u1ecdng c\u1ea5p. Thu\u1ed1c c\u00f3 gi\u00e1 kho\u1ea3ng 80.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 10 v\u1ec9 x 10 vi\u00ean.<\/p>\n
T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Difelene?<\/h2>\n\n\n\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/td>\n Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n
Diclofenac l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb v\u00e0 ki\u1ec3m so\u00e1t c\u01a1n \u0111au c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh li\u00ean quan \u0111\u1ebfn t\u00ecnh tr\u1ea1ng vi\u00eam, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng b\u1ec7nh li\u00ean quan \u0111\u1ebfn h\u1ec7 c\u01a1 x\u01b0\u01a1ng.<\/td>\n Diclofenac c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nh\u00f3m thu\u1ed1c NSAID do \u1ee9c ch\u1ebf enzyme COX nh\u01b0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean ti\u00eau h\u00f3a, tim m\u1ea1ch, th\u1eadn, gan.<\/td>\n<\/tr>\n
Khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, diclofenac \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng v\u00e0 li\u00ean k\u1ebft v\u1edbi albumin trong huy\u1ebft t\u01b0\u01a1ng. Thu\u1ed1c t\u1eadp trung trong d\u1ecbch kh\u1edbp \u0111\u1ec3 th\u1ef1c hi\u1ec7n t\u00e1c d\u1ee5ng gi\u1ea3m vi\u00eam trong c\u00e1c b\u1ec7nh v\u1ec1 c\u01a1 x\u01b0\u01a1ng kh\u1edbp.<\/td>\n Ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c d\u00f9ng pantoprazol \u1edf ph\u1ee5 n\u1eef mang thai.<\/td>\n<\/tr>\n
D\u1ea1ng b\u00e0o ch\u1ebf l\u00e0 vi\u00ean n\u00e9n bao phim gi\u00fap che gi\u1ea5u \u0111\u01b0\u1ee3c m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t, nh\u1ecf g\u1ecdn, thu\u1eadn ti\u1ec7n trong s\u1eed d\u1ee5ng.<\/td>\n <\/td>\n<\/tr>\n
Difelene \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Thai Nakorn Patana Vi\u1ec7t Nam c\u00f3 nh\u00e0 m\u00e1y \u0111\u1ea1t chu\u1ea9n GMP-WHO.<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
\n
T\u00e1c gi\u1ea3 Robert A. Alfaro v\u00e0 c\u1ed9ng s\u1ef1 (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 22 th\u00e1ng 05 n\u0103m 2023). Diclofenac<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, t\u1eeb https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557879\/<\/a><\/li>\n
T\u00e1c gi\u1ea3 R E Small. (Th\u1eddi gian ph\u00e1t h\u00e0nh th\u00e1ng 08 n\u0103m 1989). Diclofenac sodium<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/2670397\/<\/a><\/li>\n
T\u00e1c gi\u1ea3 Tong J Gan. (Th\u1eddi gian ph\u00e1t h\u00e0nh th\u00e1ng 07 n\u0103m 2010). Diclofenac: an update on its mechanism of action and safety profile<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, https:\/\/pubmed.ncbi.nlm.nih.gov\/20470236\/<\/a><\/li>\n
H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF T\u1ea0I \u0110\u00c2Y<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c Difelene ch\u1ee9a ho\u1ea1t ch\u1ea5t Natri Diclofenac v\u1edbi h\u00e0m l\u01b0\u1ee3ng 50mg d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 tho\u00e1i ho\u00e1 kh\u1edbp, vi\u00eam \u0111\u1ed1t s\u1ed1ng c\u1ee9ng kh\u1edbp, th\u1ea5p kh\u1edbp v\u00e0 vi\u00eam x\u01b0\u01a1ng kh\u1edbp m\u1ea1n t\u00ednh<\/p>\n","protected":false},"author":490,"featured_media":48782,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-48781","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/48781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=48781"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/48782"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=48781"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=48781"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=48781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Tr\u00ecnh b\u00e0y<\/h3>\nS\u0110K: VD-28618-17.\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 10 vi\u00ean.\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n

Thu\u1ed1c Difelene c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Difelene<\/h2>\n

T\u00e1c \u0111\u1ed9ng tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\nKh\u00f4ng c\u00f3 b\u00e1o c\u00e1o v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: VD-28618-17.
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 10 vi\u00ean.
\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n

T\u00e1c \u0111\u1ed9ng tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n
Kh\u00f4ng c\u00f3 b\u00e1o c\u00e1o v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n