{"id":48747,"date":"2023-10-14T11:00:22","date_gmt":"2023-10-14T04:00:22","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=48747"},"modified":"2025-07-24T14:01:47","modified_gmt":"2025-07-24T07:01:47","slug":"cotrimoxazole-400-80","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/cotrimoxazole-400-80\/","title":{"rendered":"Cotrimoxazole 400\/80"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/cotrimoxazole-400-80\/\">Cotrimoxazole 400\/80<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH LD Stellapharm &#8211; Chi nh\u00e1nh 1, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-23965-15<\/strong><\/p>\n<h2>Cotrimoxazole 400\/80 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Cotrimoxazole 400\/80<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<p>Ho\u1ea1t ch\u1ea5t:<\/p>\n<ul>\n<li>Sulfamethoxazole 400 mg<\/li>\n<li>Trimethoprim: 80 mg.<\/li>\n<\/ul>\n<p>T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-23965-15.<br \/>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean.<br \/>\nXu\u1ea5t x\u1ee9:Vi\u1ec7t Nam.<\/p>\n<h2>Thu\u1ed1c Cotrimoxazole 400\/80 c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<ul>\n<li>Cotrimoxazole l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a sulfamethoxazole v\u00e0 trimethoprim v\u1edbi t\u1ef7 l\u1ec7 5:1.<\/li>\n<li>Sulfamethoxazole l\u00e0 m\u1ed9t sulfonamid, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf c\u1ea1nh tranh qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p acid folic c\u1ee7a vi khu\u1ea9n.<\/li>\n<li>Trimethoprim l\u00e0 d\u1eabn ch\u1ea5t c\u1ee7a pyrimidin, kh\u00e1ng khu\u1ea9n b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf enzym dihydrofolat reductase c\u1ee7a vi khu\u1ea9n.<\/li>\n<li>Nh\u01b0 v\u1eady, trimethoprim v\u00e0 sulfamethoxazole \u1ee9c ch\u1ebf hai giai \u0111o\u1ea1n li\u00ean ti\u1ebfp trong chuy\u1ec3n h\u00f3a acid folic, t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p thymidin, purin v\u00e0 DNA c\u1ee7a vi khu\u1ea9n, cu\u1ed1i c\u00f9ng vi khu\u1ea9n b\u1ecb ti\u00eau di\u1ec7t. Ngo\u00e0i ra, s\u1ef1 ph\u1ed1i h\u1ee3p n\u00e0y gi\u00fap ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng thu\u1ed1c, thu\u1ed1c v\u1eabn c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng l\u1ea1i vi khu\u1ea9n \u0111\u00e3 kh\u00e1ng t\u1eebng th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c.<\/li>\n<li>Ph\u1ed5 kh\u00e1ng khu\u1ea9n c\u1ee7a thu\u1ed1c tr\u00ean c\u00e1c vi sinh v\u1eadt sau: Klebsiella spp., E. coli, Morganella morganii, Enterobacter spp., S. pneumoniae, Proteus mirabilis, Proteus indol d\u01b0\u01a1ng t\u00ednh, bao g\u1ed3m c\u1ea3 P. vulgaris, H. influenzae, Shigella sonnei, Shigella flexneri, Pneumocystis carinii, Plasmodium falciparum, Toxoplasma gondii.<\/li>\n<li>C\u00e1c vi sinh v\u1eadt th\u01b0\u1eddng kh\u00e1ng thu\u1ed1c l\u00e0: Pseudomonas, Enterococcus, vi khu\u1ea9n k\u1ef5 kh\u00ed (Anaerobes), Campylobacter, l\u1eadu c\u1ea7u (Gonococcus), n\u00e3o m\u00f4 c\u1ea7u (Meningococcus), Mycoplasma.<\/li>\n<li>Trong invitro, kh\u00e1ng thu\u1ed1c cotrimoxazole x\u1ea3y ra ch\u1eadm h\u01a1n so v\u1edbi t\u1eebng th\u00e0nh ph\u1ea7n \u0111\u01a1n \u0111\u1ed9c c\u1ee7a thu\u1ed1c v\u00e0 t\u0103ng \u1edf c\u1ea3 vi khu\u1ea9n Gram d\u01b0\u01a1ng v\u00e0 Gram \u00e2m. \u0110\u1ec1 kh\u00e1ng \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi Enterobacter.<\/li>\n<\/ul>\n<h3>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu<\/li>\n<\/ul>\n<p>Cotrimoxazole d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng h\u1ea5p thu t\u1ed1t v\u00e0 nhanh. Sau 1 &#8211; 4 gi\u1edd khi u\u1ed1ng li\u1ec1u \u0111\u01a1n cotrimoxazole (trimethoprim 160mg v\u00e0 sulfamethoxazole 800 mg) thu\u1ed1c \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a trimethoprim l\u00e0 1 &#8211; 2 mcg\/ml v\u00e0 sulfamethoxazole kh\u00f4ng g\u1eafn k\u1ebft l\u00e0 40 &#8211; 60 mcg\/ml.<\/p>\n<ul>\n<li>Ph\u00e2n b\u1ed1<\/li>\n<\/ul>\n<p>Cotrimoxazole ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp trong m\u00f4 v\u00e0 d\u1ecbch c\u01a1 th\u1ec3 (n\u01b0\u1edbc b\u1ecdt, d\u1ecbch tai gi\u1eefa, th\u1ee7y d\u1ecbch, d\u1ecbch \u00e2m \u0111\u1ea1o, d\u1ecbch tuy\u1ebfn ti\u1ec1n li\u1ec7t, m\u1eadt v\u00e0 d\u1ecbch n\u00e3o t\u1ee7y), trimethoprim c\u00f2n ph\u00e2n b\u1ed1 trong d\u1ecbch ti\u1ebft ph\u1ed5i. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a sulfamethoxazole th\u1ea5p h\u01a1n trimethoprim. Cotrimoxazole qua \u0111\u01b0\u1ee3c nhau thai v\u00e0 s\u1eefa m\u1eb9.<br \/>\nKh\u1ea3 n\u0103ng g\u1eafn c\u1ee7a Trimethoprim v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng l\u00e0 44% v\u00e0 sulfamethoxazole kho\u1ea3ng 70%. Cotrimoxazole d\u1ec5 d\u00e0ng qua nhau thai v\u00e0 ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<ul>\n<li>Chuy\u1ec3n h\u00f3a<\/li>\n<\/ul>\n<p>Cotrimoxazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan.<\/p>\n<ul>\n<li>Th\u1ea3i tr\u1eeb<\/li>\n<\/ul>\n<p>Ng\u01b0\u1eddi l\u1edbn c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a trimethoprim v\u00e0 sulfamethoxazole l\u1ea7n l\u01b0\u1ee3t l\u00e0 8 &#8211; 11 gi\u1edd v\u00e0 10 &#8211; 13 gi\u1edd. Trong 24 gi\u1edd, c\u00f3 kho\u1ea3ng 50 &#8211; 60% trimethoprim v\u00e0 45 &#8211; 70% sulfamethoxazole li\u1ec1u u\u1ed1ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u.<br \/>\nKho\u1ea3ng 80% trimethoprim v\u00e0 20% sulfamethoxazole \u0111\u01b0\u1ee3c c\u00f3 m\u1eb7t trong n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. L\u01b0\u1ee3ng nh\u1ecf trimethoprim b\u00e0i ti\u1ebft \u1edf m\u1eadt v\u00e0 th\u1ea3i tr\u1eeb qua ph\u00e2n.<\/p>\n<h2>Thu\u1ed1c Cotrimoxazole 400\/80 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Vi\u00eam tai gi\u1eefa c\u1ea5p t\u00ednh.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u m\u1ea1n t\u00ednh ho\u1eb7c t\u00e1i ph\u00e1t.<\/li>\n<li>Vi\u00eam tuy\u1ebfn ti\u1ec1n li\u1ec7t.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<li>B\u1ec7nh brucella.<\/li>\n<li>B\u1ec7nh t\u1ea3.<\/li>\n<li>B\u1ec7nh d\u1ecbch h\u1ea1ch.<\/li>\n<li>Vi\u00eam ph\u1ed5i g\u00e2y ra b\u1edfi Pneumocystis jiroveci (Pneumocystis carinii).<\/li>\n<li>B\u1ec7nh toxoplasma.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Cotrimoxazole 400\/80<\/h2>\n<h3>Cotrimoxazole 400\/80 c\u00e1ch d\u00f9ng<\/h3>\n<p>\u0110\u1ec3 l\u00e0m gi\u1ea3m r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, n\u00ean u\u1ed1ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n ho\u1eb7c \u0111\u1ed3 u\u1ed1ng.<\/p>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 20.8508%;text-align: center\">Tr\u01b0\u1eddng h\u1ee3p<\/td>\n<td style=\"width: 79.1492%;text-align: center\">Li\u1ec1u l\u01b0\u1ee3ng<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Vi\u00eam tai gi\u1eefa c\u1ea5p<\/td>\n<td style=\"width: 79.1492%\">Tr\u1ebb em tr\u00ean 2 th\u00e1ng tu\u1ed5i: Li\u1ec1u th\u00f4ng th\u01b0\u1eddng l\u00e0 8mg trimethoprim (trong vi\u00ean cotrimoxazole)\/kg c\u00e2n n\u1eb7ng\/ng\u00e0y, chia 2 l\u1ea7n c\u00e1ch nhau 12 gi\u1edd, \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng trong 10 ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u m\u1ea1n t\u00ednh ho\u1eb7c t\u00e1i ph\u00e1t ho\u1eb7c vi\u00eam tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/td>\n<td style=\"width: 79.1492%\">Ng\u01b0\u1eddi l\u1edbn<br \/>\nV\u1edbi nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u m\u1ea1n ho\u1eb7c t\u00e1i ph\u00e1t: 160 mg trimethoprim (trong vi\u00ean cotrimoxazole), 2 l\u1ea7n\/ng\u00e0y, c\u00e1ch 12 gi\u1edd, trong 10 &#8211; 14 ng\u00e0y v\u00e0 v\u1edbi vi\u00eam tuy\u1ebfn ti\u1ec1n li\u1ec7t th\u00ec \u0111i\u1ec1u tr\u1ecb trong 3 &#8211; 6 th\u00e1ng.<br \/>\nD\u1ef1 ph\u00f2ng nhi\u1ec5m khu\u1ea9n m\u1ea1n ho\u1eb7c t\u00e1i ph\u00e1t \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u: Ng\u01b0\u1eddi l\u1edbn: d\u00f9ng 40 &#8211; 80 mg trimethoprim (trong vi\u00ean cotrimoxazole)\/ng\u00e0y ho\u1eb7c 3 l\u1ea7n\/tu\u1ea7n trong 3 &#8211; 6 th\u00e1ng. Tr\u1ebb em tr\u00ean 2 th\u00e1ng tu\u1ed5i th\u01b0\u1eddng d\u00f9ng 8mg trimethoprim (trong vi\u00ean cotrimoxazole)\/kg\/ng\u00e0y chia 2 l\u1ea7n c\u00e1ch nhau 12 gi\u1edd.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p<\/td>\n<td style=\"width: 79.1492%\">Ng\u01b0\u1eddi l\u1edbn: 160 mg trimethoprim (trong vi\u00ean cotrimoxazole)\/1 l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y c\u00e1ch nhau 12 gi\u1edd, trong 14 ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a do tr\u1ef1c khu\u1ea9n l\u1ef5<\/td>\n<td style=\"width: 79.1492%\">Ng\u01b0\u1eddi l\u1edbn: 160 mg trimethoprim (trong vi\u00ean cotrimoxazole)\/1 l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y c\u00e1ch nhau 12 gi\u1edd.<br \/>\nTr\u1ebb em: 8 mg trimethoprim (trong vi\u00ean cotrimoxazole)\/kg\/ng\u00e0y, chia 2 l\u1ea7n c\u00e1ch nhau 12 gi\u1edd, trong 5 ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">B\u1ec7nh brucella \u1edf tr\u1ebb em<\/td>\n<td style=\"width: 79.1492%\">10mg trimethoprim (trong vi\u00ean cotrimoxazole)\/kg\/ng\u00e0y x 2 l\u1ea7n\/ng\u00e0y trong 4 &#8211; 6 tu\u1ea7n (t\u1ed1i \u0111a 480 mg\/ng\u00e0y).<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">B\u1ec7nh t\u1ea3<\/td>\n<td style=\"width: 79.1492%\">Ng\u01b0\u1eddi l\u1edbn: 160 mg trimethoprim (trong vi\u00ean cotrimoxazole) x 2 l\u1ea7n\/ng\u00e0y, trong 3 ng\u00e0y.<br \/>\nTr\u1ebb em: 4 &#8211; 5 mg\/kg trimethoprim (trong vi\u00ean cotrimoxazole) x 2 l\u1ea7n\/ng\u00e0y, trong 3 ng\u00e0y, k\u1ebft h\u1ee3p b\u00f9 d\u1ecbch v\u00e0 \u0111i\u1ec7n gi\u1ea3i.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">B\u1ec7nh d\u1ecbch h\u1ea1ch<\/td>\n<td style=\"width: 79.1492%\">D\u1ef1 ph\u00f2ng \u1edf ng\u01b0\u1eddi l\u1edbn: 320 &#8211; 640 mg\/ng\u00e0y\u00a0 trimethoprim (trong vi\u00ean cotrimoxazole), chia 2 l\u1ea7n c\u00e1ch nhau 12 gi\u1edd, trong 7 ng\u00e0y.<br \/>\nTr\u1ebb em tr\u00ean 2 th\u00e1ng tu\u1ed5i: 8mg trimethoprim (trong vi\u00ean cotrimoxazole)\/kg\/ng\u00e0y x 2 l\u1ea7n\/ng\u00e0y, trong 7 ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Vi\u00eam ph\u1ed5i do Pneumocystis jiroveci<\/td>\n<td style=\"width: 79.1492%\">Tr\u1ebb em t\u1eeb 2 th\u00e1ng tu\u1ed5i tr\u1edf l\u00ean v\u00e0 ng\u01b0\u1eddi l\u1edbn: 15 &#8211; 20 mg\/kg\/ng\u00e0y trimethoprim (trong vi\u00ean cotrimoxazole), chia 3 &#8211; 4 li\u1ec1u b\u1eb1ng nhau, \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng t\u1eeb 14 \u2013 21 ng\u00e0y.<br \/>\nD\u1ef1 ph\u00f2ng \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 thi\u1ebfu ni\u00ean nhi\u1ec5m HIV: 160 mg\/1 l\u1ea7n\/ng\u00e0y trimethoprim (trong vi\u00ean cotrimoxazole) ho\u1eb7c 80 mg\/l\u1ea7n\/ng\u00e0y trimethoprim (trong vi\u00ean cotrimoxazole).<br \/>\nD\u1ef1 ph\u00f2ng \u1edf tr\u1ebb em, bao g\u1ed3m c\u1ea3 tr\u1ebb nhi\u1ec5m HIV: U\u1ed1ng gi\u00e1n \u0111o\u1ea1n li\u1ec1u 150 mg\/ m\u00e9t vu\u00f4ng trimethoprim (trong vi\u00ean cotrimoxazole), chia 2 l\u1ea7n, u\u1ed1ng m\u1ed7i tu\u1ea7n 3 ng\u00e0y li\u1ec1n.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">B\u1ec7nh toxoplasma<\/td>\n<td style=\"width: 79.1492%\">D\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 thi\u1ebfu ni\u00ean: li\u1ec1u 160 mg\/l\u1ea7n\/ng\u00e0y ho\u1eb7c 80 mg\/l\u1ea7n\/ng\u00e0y trimethoprim u\u1ed1ng (trong vi\u00ean cotrimoxazole).<br \/>\nD\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t \u1edf tr\u1ebb em nhi\u1ec5m HIV li\u1ec1u 150 mg\/m2\/ng\u00e0y trimethoprim (trong vi\u00ean cotrimoxazole), chia l\u00e0m 2 l\u1ea7n.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20.8508%\">Suy th\u1eadn<\/td>\n<td style=\"width: 79.1492%\">\u0110\u1ed9 thanh th\u1ea3i creatinin &gt;30 ml\/ph\u00fat: d\u00f9ng li\u1ec1u th\u00f4ng th\u01b0\u1eddng.<br \/>\n\u0110\u1ed9 thanh th\u1ea3i creatinin 15 &#8211; 30 ml\/ph\u00fat: gi\u1ea3m li\u1ec1u c\u00f2n m\u1ed9t n\u1eeda.<br \/>\n\u0110\u1ed9 thanh th\u1ea3i creatinin &lt; 15 ml\/ph\u00fat: Kh\u00f4ng d\u00f9ng.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Cotrimoxazole 400\/80 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>B\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>T\u1ed5n th\u01b0\u01a1ng gan n\u1eb7ng.<\/li>\n<li>Tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn n\u1eb7ng, \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 15 ml\/ph\u00fat ho\u1eb7c ch\u1ee9c n\u0103ng th\u1eadn kh\u00f4ng ki\u1ec3m so\u00e1t.<\/li>\n<li>B\u1ec7nh nh\u00e2n thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u.<\/li>\n<li>Ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa.<\/li>\n<li>Tr\u1ebb d\u01b0\u1edbi 2 th\u00e1ng tu\u1ed5i.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Cotrimoxazole 400\/80<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Kh\u00f4ng n\u00ean d\u00f9ng cotrimoxazole trong vi\u00eam h\u1ecdng do S. Pyogenes.<\/li>\n<li>Th\u1eadn tr\u1ecdng khi d\u00f9ng v\u1edbi b\u1ec7nh nh\u00e2n suy th\u1eadn, b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 thi\u1ebfu h\u1ee5t folat, b\u1ec7nh nh\u00e2n b\u1ecb d\u1ecb \u1ee9ng n\u1eb7ng, hen ph\u1ebf qu\u1ea3n, thi\u1ebfu h\u1ee5t G6PD(G-6-PD).<\/li>\n<li>Duy tr\u00ec u\u1ed1ng n\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7 khi \u0111ang u\u1ed1ng cotrimoxazole \u0111\u1ec3 tr\u00e1nh k\u1ebft tinh n\u01b0\u1edbc ti\u1ec3u v\u00e0 h\u00ecnh th\u00e0nh s\u1ecfi ni\u1ec7u.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i v\u1edbi cotrimoxazole, c\u1ea7n th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra c\u00f4ng th\u1ee9c m\u00e1u, n\u01b0\u1edbc ti\u1ec3u, ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<li>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a thu\u1ed1c hay g\u1eb7p \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p l\u00e0 bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, bi\u1ebfng \u0103n.<\/p>\n<p>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn:<br \/>\n+ Th\u01b0\u1eddng g\u1eb7p: S\u1ed1t, ban, ng\u1ee9a, vi\u00eam da tr\u00f3c v\u1ea3y, nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng v\u00e0 h\u1ed3ng ban.<br \/>\n+ Nghi\u00eam tr\u1ecdng: h\u1ed9i ch\u1ee9ng Stevens-Johnson, c\u00f3 th\u1ec3 t\u1eed vong, c\u00e1c ph\u1ea3n \u1ee9ng tr\u00ean da.<\/p>\n<p>\u0110\u1ed9c tr\u00ean th\u1eadn: Vi\u00eam th\u1eadn k\u1ebd v\u00e0 ho\u1ea1i t\u1eed \u1ed1ng th\u1eadn, ti\u1ec3u ra m\u00e1u, \u0111au th\u1eaft l\u01b0ng,\u00a0 ti\u1ec3u \u00edt v\u00e0 kh\u00f3 ti\u1ec3u c\u00f3 th\u1ec3 x\u1ea3y ra.<\/p>\n<p>R\u1ed1i lo\u1ea1n m\u00e1u: M\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, thi\u1ebfu m\u00e1u b\u1ea5t s\u1ea3n, gi\u1ea3m prothrombin, t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin.<\/p>\n<p>R\u1ed1i lo\u1ea1n h\u1ec7 enzym gan, v\u00e0ng da \u1ee9 m\u1eadt.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Warfarin d\u00f9ng c\u00f9ng v\u1edbi Cotrimoxazole c\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian \u0111\u00f4ng m\u00e1u c\u1ee7a b\u1ec7nh nh\u00e2n.<\/li>\n<li>Cotrimoxazole \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a phenytoin.<\/li>\n<li>Methotrexat: Cotrimoxazole c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 methotrexat t\u1ef1 do. Cyclosporin: d\u00f9ng cotrimoxazole c\u00f9ng v\u1edbi cyclosporin c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c th\u1eadn nh\u01b0ng c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c \u1edf b\u1ec7nh nh\u00e2n c\u1ea5y gh\u00e9p th\u1eadn.<\/li>\n<li>Digoxin: T\u0103ng n\u1ed3ng \u0111\u1ed9 digoxin trong huy\u1ebft thanh khi d\u00f9ng c\u00f9ng cotrimoxazole, \u0111\u1eb7c bi\u1ec7t l\u00e0 ng\u01b0\u1eddi cao tu\u1ed5i.<\/li>\n<li>Indomethacin: d\u00f9ng c\u00f9ng Cotrimoxazole c\u00f3 th\u1ec3 g\u00e2y t\u0103ng n\u1ed3ng \u0111\u1ed9 sulfamethoxazole.<\/li>\n<li>Pyrimethamin: D\u00f9ng cotrimoxazole v\u00e0 pyrimethamin qu\u00e1 25 mg\/tu\u1ea7n \u0111\u00e3 g\u00e2y thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u to.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m hi\u1ec7u qu\u1ea3 khi d\u00f9ng Cotrimoxazole.<\/li>\n<li>Amantadin: khi d\u00f9ng k\u1ebft h\u1ee3p cotrimoxazole \u0111\u00e3 x\u1ea3y ra m\u00ea s\u1ea3ng, nhi\u1ec5m \u0111\u1ed9c.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef mang thai<\/li>\n<\/ul>\n<p>Cotrimoxazole c\u00f3 th\u1ec3 qua nhau thai, ch\u1ec9 d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef mang thai khi \u0111\u00e3 c\u00e2n nh\u1eafc c\u1ea9n th\u1eadn gi\u1eefa l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 g\u00e2y h\u1ea1i. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y v\u00ec nguy c\u01a1 g\u00e2y v\u00e0ng da \u1edf tr\u1ebb.<\/p>\n<ul>\n<li>Ph\u1ee5 n\u1eef cho con b\u00fa<\/li>\n<\/ul>\n<p>Cotrimoxazole qua \u0111\u01b0\u1ee3c s\u1eefa m\u1eb9, g\u00e2y v\u00e0ng da \u1edf tr\u1ebb d\u01b0\u1edbi 2 th\u00e1ng. C\u00e2n nh\u1eafc ng\u1eebng cho con b\u00fa ho\u1eb7c ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c trong giai \u0111o\u1ea1n n\u00e0y.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u x\u1ea3y ra v\u1edbi bi\u1ec3u hi\u1ec7n: sa s\u00fat tr\u00ed tu\u1ec7, n\u00f4n, bu\u1ed3n n\u00f4n, l\u00fa l\u1eabn, \u0111au \u0111\u1ea7u, suy t\u1ee7y, s\u01b0ng m\u1eb7t,&#8230;<\/p>\n<p>X\u1eed tr\u00ed: g\u00e2y n\u00f4n ho\u1eb7c r\u1eeda d\u1ea1 d\u00e0y, \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng, c\u00f3 th\u1ec3 th\u1ea9m ph\u00e2n m\u00e1u. Th\u1ea9m ph\u00e2n m\u00e0ng b\u1ee5ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng<\/p>\n<h3>T\u00e1c \u0111\u1ed9ng tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, \u00f9 tai,m\u1ea5t ng\u1ee7, bu\u1ed3n ng\u1ee7,&#8230; \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, do v\u1eady c\u1ea7n \u0111\u1eb7c bi\u1ec7t ch\u00fa \u00fd.<\/p>\n<h2>Thu\u1ed1c Cotrimoxazole 400\/80 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Cotrimoxazole 400\/80<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/cotrimstada-forte\/\">Cotrimstada Forte<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH D\u01b0\u1ee3c ph\u1ea9m M.S.T, ch\u1ee9a Sulfamethoxazole v\u1edbi h\u00e0m l\u01b0\u1ee3ng 800mg v\u00e0 Trimethoprim v\u1edbi h\u00e0m l\u01b0\u1ee3ng 160mg. Thu\u1ed1c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb \u0111\u1ee3t c\u1ea5p \u1edf b\u1ec7nh nh\u00e2n vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n, vi\u00eam ti\u1ec1n li\u1ec7t tuy\u1ebfn, vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, ti\u1ebft ni\u1ec7u, ti\u00eau h\u00f3a v\u00e0 c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng. Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n. \u0110\u1ed1i v\u1edbi nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u b\u1ea1n c\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c trong 10 ng\u00e0y, 1-2 vi\u00ean\/l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y. Thu\u1ed1c c\u00f3 gi\u00e1 kho\u1ea3ng 88.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 2 v\u1ec9 x 10 vi\u00ean.<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/pms-cotrim-960mg\/\">Pms-Cotrim 960mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m IMEXPHARM, ch\u1ee9a Sulfamethoxazole v\u1edbi h\u00e0m l\u01b0\u1ee3ng 800mg v\u00e0 Trimethoprim v\u1edbi h\u00e0m l\u01b0\u1ee3ng 160mg. Thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n h\u00f4 h\u1ea5p, nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u v\u00e0 sinh d\u1ee5c, nhi\u1ec5m khu\u1ea9n ti\u00eau h\u00f3a. Trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n h\u00f4 h\u1ea5p: U\u1ed1ng 1-2 vi\u00ean\/l\u1ea7n, ng\u00e0y 2-3 l\u1ea7n. Thu\u1ed1c c\u00f3 gi\u00e1 kho\u1ea3ng 63.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 10 v\u1ec9 x 10 vi\u00ean.<\/p>\n<h2>T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Cotrimoxazole 400\/80?<\/h2>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 58.5077%;text-align: center\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 41.4923%;text-align: center\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 58.5077%\">Cotrimoxazole 400\/80 l\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a trimethoprim v\u00e0 sulfamethoxazole gi\u00fap \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n nh\u01b0: nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u v\u00e0 sinh d\u1ee5c, nhi\u1ec5m khu\u1ea9n ti\u00eau h\u00f3a.<\/td>\n<td style=\"width: 41.4923%\">C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p l\u00e0 bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, bi\u1ebfng \u0103n.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 58.5077%\">Ph\u1ed1i h\u1ee3p trimethoprim v\u00e0 sulfamethoxazole gi\u00fap ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng thu\u1ed1c, thu\u1ed1c v\u1eabn c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng l\u1ea1i vi khu\u1ea9n \u0111\u00e3 kh\u00e1ng t\u1eebng th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c.<\/td>\n<td style=\"width: 41.4923%\">Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y v\u00e0ng da \u1edf tr\u1ebb, kh\u00f4ng s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 58.5077%\">Ph\u1ed5 kh\u00e1ng khu\u1ea9n r\u1ed9ng kh\u1eafp tr\u00ean h\u1ea7u h\u1ebft c\u00e1c vi khu\u1ea9n.<\/td>\n<td style=\"width: 41.4923%\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 58.5077%\">Gi\u00e1 th\u00e0nh c\u1ee7a s\u1ea3n ph\u1ea9m kh\u00e1 r\u1ebb.<\/td>\n<td style=\"width: 41.4923%\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u00e1c gi\u1ea3 Tyler R. Kemnic v\u00e0 c\u1ed9ng s\u1ef1 (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 28 th\u00e1ng 11 n\u0103m 2022). <em>Trimethoprim Sulfamethoxazole<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30020604\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30020604\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 J B Howard v\u00e0 c\u1ed9ng s\u1ef1. (Th\u1eddi gian ph\u00e1t h\u00e0nh th\u00e1ng 11 n\u0103m 1978). <em>Trimethoprim-sulfamethoxazole vs sulfamethoxazole for acute urinary tract infections in children<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/362893\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/362893\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3 Philip A Masters v\u00e0 c\u1ed9ng s\u1ef1. (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 24 th\u00e1ng 02 n\u0103m 2003). <em>Trimethoprim-sulfamethoxazole revisited<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 10 n\u0103m 2023, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12588198\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/12588198\/<\/a><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2023\/10\/cotrimoxazole-400-80-vnras.pdf\">T\u1ea0I \u0110\u00c2Y<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Cotrimoxazole 400\/80 l\u00e0 s\u1ef1 k\u1ebft h\u01a1p c\u1ee7a Sulfamethoxazole 400mg v\u00e0 Trimethoprim 80mg c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n nh\u01b0 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, ti\u1ebft ni\u1ec7u, ti\u00eau h\u00f3a,&#8230;<\/p>\n","protected":false},"author":490,"featured_media":48748,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-48747","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/48747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=48747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/48748"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=48747"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=48747"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=48747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}