{"id":46970,"date":"2023-10-04T18:00:54","date_gmt":"2023-10-04T11:00:54","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=46970"},"modified":"2025-07-24T14:02:03","modified_gmt":"2025-07-24T07:02:03","slug":"nexium-10mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/nexium-10mg\/","title":{"rendered":"Nexium 10mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Nexium 10mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty AstraZeneca, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-17834-14<\/b>.<\/span><\/p>\n

Nexium 10mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n
Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n
Thu\u1ed1c c\u1ed1m Nexium 10mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n trong m\u1ed7i g\u00f3i:<\/span><\/p>\n
Esomeprazole\u2026\u2026\u2026\u2026\u2026.. 10mg (d\u01b0\u1edbi d\u1ea1ng magnesi trihydrat)<\/span><\/p>\n
T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/span><\/p>\n
D\u1ea1ng b\u00e0o ch\u1ebf: C\u1ed1m kh\u00e1ng d\u1ecbch d\u1ea1 d\u00e0y \u0111\u1ec3 pha h\u1ed7n d\u1ecbch u\u1ed1ng.<\/span><\/p>\n
Tr\u00ecnh b\u00e0y<\/span><\/h3>\n
S\u0110K: VN-17834-14<\/span><\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i:<\/span><\/p>\n
Xu\u1ea5t x\u1ee9: Th\u1ee5y \u0110i\u1ec3n<\/span><\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Nexium 10mg<\/span><\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\n
Nexium 10mg c\u00f3 ph\u1ea3i kh\u00e1ng sinh kh\u00f4ng<\/b> ?<\/span><\/p>\n
Esomeprazole l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (PPI) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n (GERD), \u0111\u1ec3 b\u1ea3o v\u1ec7 d\u1ea1 d\u00e0y nh\u1eb1m ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng d\u1ea1 d\u00e0y do s\u1eed d\u1ee5ng NSAID l\u00e2u d\u00e0i v\u00e0 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb. \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft b\u1ec7nh l\u00fd bao g\u1ed3m H\u1ed9i ch\u1ee9ng Zollinger-Ellison (ZE). N\u00f3 c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e1c \u0111\u1ed3 4 thu\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb H. pylorinhi\u1ec5m tr\u00f9ng c\u00f9ng v\u1edbi c\u00e1c lo\u1ea1i kh\u00e1ng sinh kh\u00e1c.\u00a0<\/span><\/p>\n
Esomeprazole ph\u00e1t huy t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf axit d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n b\u01b0\u1edbc cu\u1ed1i c\u00f9ng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t axit d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi c\u00e1c nh\u00f3m sulfhydryl c\u1ee7a cystein c\u00f3 tr\u00ean enzyme (H+, K+)-ATPase \u1edf b\u1ec1 m\u1eb7t b\u00e0i ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. T\u00e1c d\u1ee5ng n\u00e0y d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf s\u1ef1 ti\u1ebft axit d\u1ea1 d\u00e0y c\u01a1 b\u1ea3n v\u00e0 do k\u00edch th\u00edch, b\u1ea5t k\u1ec3 t\u00e1c nh\u00e2n k\u00edch th\u00edch. V\u00ec s\u1ef1 g\u1eafn k\u1ebft c\u1ee7a esomeprazole v\u1edbi enzyme (H+, K+)-ATPase l\u00e0 kh\u00f4ng th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c v\u00e0 enzyme m\u1edbi c\u1ea7n \u0111\u01b0\u1ee3c ti\u1ebft ra \u0111\u1ec3 ti\u1ebfp t\u1ee5c ti\u1ebft axit, n\u00ean th\u1eddi gian t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft c\u1ee7a esomeprazole k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd. C\u00e1c PPI nh\u01b0 esomeprazole c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a dimethylarginine .dimethylaminohydrolase (DDAH), m\u1ed9t lo\u1ea1i enzyme c\u1ea7n thi\u1ebft cho s\u1ee9c kh\u1ecfe tim m\u1ea1ch. S\u1ef1 \u1ee9c ch\u1ebf DDAH g\u00e2y ra s\u1ef1 t\u00edch t\u1ee5 ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p oxit nitric kh\u00f4ng \u0111\u1ed1i x\u1ee9ng dimethylarginie ( ADMA ), \u0111\u01b0\u1ee3c cho l\u00e0 g\u00e2y ra m\u1ed1i li\u00ean quan gi\u1eefa PPI v\u1edbi vi\u1ec7c t\u0103ng nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh kh\u00f4ng \u1ed5n \u0111\u1ecbnh.\u00a0<\/span><\/p>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n
H\u1ea5p th\u1ee5: Sau khi u\u1ed1ng, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (Cmax) \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 1,5 gi\u1edd (Tmax). Cmax t\u0103ng t\u1ef7 l\u1ec7 thu\u1eadn khi t\u0103ng li\u1ec1u v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng theo th\u1eddi gian (AUC) t\u0103ng g\u1ea5p ba l\u1ea7n t\u1eeb 20 \u0111\u1ebfn 40 mg.<\/span><\/p>\n
Ph\u00e2n b\u1ed1: Esomeprazole li\u00ean k\u1ebft 97% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kh\u00f4ng \u0111\u1ed5i trong kho\u1ea3ng n\u1ed3ng \u0111\u1ed9 t\u1eeb 2 \u0111\u1ebfn 20 umol\/L. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn \u200b\u200b\u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh l\u00e0 kho\u1ea3ng 16 L.<\/span><\/p>\n
Chuy\u1ec3n h\u00f3a: Esomeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan nh\u1edd h\u1ec7 th\u1ed1ng enzym cytochrome P450 (CYP). C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a esomeprazole kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng ti\u1ebft. Ph\u1ea7n l\u1edbn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u1ee7a esomeprazole ph\u1ee5 thu\u1ed9c v\u00e0o isoenzym CYP2C19, ch\u1ea5t t\u1ea1o th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxy v\u00e0 desmethyl. L\u01b0\u1ee3ng c\u00f2n l\u1ea1i ph\u1ee5 thu\u1ed9c v\u00e0o CYP3A4 \u0111\u1ec3 t\u1ea1o th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a sulphone.<\/span><\/p>\n
Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a esomeprazole kho\u1ea3ng 1 \u0111\u1ebfn 1,5 gi\u1edd. \u00cdt h\u01a1n 1% thu\u1ed1c g\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u. Kho\u1ea3ng 80% li\u1ec1u u\u1ed1ng esomeprazole \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 ph\u1ea7n c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e2n d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh.<\/span><\/p>\n
Thu\u1ed1c Nexium 10mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n
Nexium 10mg<\/b> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n
Tr\u1ebb em t\u1eeb 1-11 tu\u1ed5i<\/span><\/i>: Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n<\/span><\/p>\n
\n
Tr\u1ebb b\u1ecb vi\u00eam x\u01b0\u1edbc th\u1ef1c qu\u1ea3n do tr\u00e0o ng\u01b0\u1ee3c \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng n\u1ed9i soi.<\/span><\/li>\n
Tr\u1ebb c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n<\/span><\/li>\n<\/ul>\n
Tr\u1ebb em t\u1eeb 4 tu\u1ed5i tr\u1edf l\u00ean<\/span><\/i><\/p>\n
S\u1eed d\u1ee5ng c\u00f9ng v\u1edbi kh\u00e1ng sinh trong \u0111i\u1ec1u tr\u1ecb lo\u00e9t t\u00e1 tr\u00e0ng do <\/span>Helicobacter pylori<\/span><\/i>.<\/span><\/p>\n
D\u00f9ng \u0111\u01b0\u1ee3c cho nh\u1eefng b\u1ec7nh nh\u00e2n nu\u1ed1t kh\u00f3 d\u1ecbch t\u00e2n t\u00e1c c\u1ee7a vi\u00ean n\u00e9n Nexium kh\u00e1ng d\u1ecbch d\u1ea1 d\u00e0y.<\/span><\/p>\n
V\u1edbi nh\u1eefng tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean xin xem th\u00eam th\u00f4ng tin k\u00ea toa c\u1ee7a Nexium vi\u00ean n\u00e9n kh\u00e1ng d\u1ecbch d\u1ea1 d\u00e0y.<\/span><\/p>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Nexium 10mg<\/span><\/h2>\n
C\u00e1ch d\u00f9ng<\/span><\/h3>\n
Nexium 10mg u\u1ed1ng tr\u01b0\u1edbc hay sau \u0103n ? <\/b>S\u1eed d\u1ee5ng thu\u1ed1c tr\u01b0\u1edbc b\u1eefa \u0103n kho\u1ea3ng 1 gi\u1edd<\/span><\/p>\n
D\u00f9ng thu\u1ed1c \u0111\u01b0\u1eddng u\u1ed1ng b\u1eb1ng c\u00e1ch pha g\u00f3i 10mg v\u00e0o ly ch\u1ee9a kho\u1ea3ng 15ml n\u01b0\u1edbc.<\/span><\/p>\n
\u0110\u1ed1i v\u1edbi li\u1ec1u 20mg: cho h\u1ebft 2 g\u00f3i thu\u1ed1c 10mg pha c\u00f9ng v\u1edbi 30ml n\u01b0\u1edbc.<\/span><\/p>\n
Khu\u1ea5y \u0111\u1ec1u thu\u1ed1c cho tan h\u1ebft v\u00e0 \u0111\u1ec3 y\u00ean v\u00e0i ph\u00fat cho \u0111\u1eb7c l\u1ea1i, r\u1ed3i khu\u1ea5y l\u1ea1i v\u00e0 u\u1ed1ng trong v\u00f2ng 30 ph\u00fat.<\/span><\/p>\n
Kh\u00f4ng nhai, nghi\u1ec1n n\u00e1t c\u1ed1m, tr\u00e1ng l\u1ea1i c\u1ed1c v\u1edbi 15ml n\u01b0\u1edbc \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u0111\u00e3 u\u1ed1ng \u0111\u1ee7 li\u1ec1u.<\/span><\/p>\n
Nexium 10mg li\u1ec1u d\u00f9ng<\/span><\/h3>\n
Nexium 10mg tr\u1ebb em<\/i><\/b><\/p>\n
Tr\u1ebb em t\u1eeb 1-11 tu\u1ed5i, c\u00e2n n\u1eb7ng \u2265 10kg: <\/span><\/i>B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n (GERD)<\/span><\/p>\n\n\n\n\n\n\n
\u0110\u1ed1i t\u01b0\u1ee3ng<\/td>\n Li\u1ec1u d\u00f9ng<\/td>\n<\/tr>\n
\u0110i\u1ec1u tr\u1ecb vi\u00eam x\u01b0\u1edbc th\u1ef1c qu\u1ea3n do tr\u00e0o ng\u01b0\u1ee3c \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng n\u1ed9i soi<\/td>\n C\u00e2n n\u1eb7ng \u2265 10 \u0111\u1ebfn < 20kg: 10mg 1 l\u1ea7n\/ng\u00e0y trong 8 tu\u1ea7n.<\/td>\n<\/tr>\n
C\u00e2n n\u1eb7ng \u2265 20kg: 10mg ho\u1eb7c 20mg 1 l\u1ea7n\/ng\u00e0y trong 8 tu\u1ea7n.<\/td>\n<\/tr>\n
\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n (GERD)<\/td>\n 10mg, 1 l\u1ea7n\/ng\u00e0y, trong 8 tu\u1ea7n.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Tr\u1ebb em t\u1eeb 4 tu\u1ed5i tr\u1edf l\u00ean: <\/span><\/i>\u0110i\u1ec1u tr\u1ecb lo\u00e9t t\u00e1 tr\u00e0ng do<\/span> Helicobacter pylori.<\/span><\/i><\/p>\n
Li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p ph\u1ee5 thu\u1ed9c v\u00e0o h\u01b0\u1edbng d\u1eabn ch\u00ednh th\u1ee9c c\u1ee7a t\u1eebng qu\u1ed1c gia, v\u00f9ng v\u00e0 \u0111\u1ecba ph\u01b0\u01a1ng v\u1ec1 nh\u1eefng \u0111\u1ec1 kh\u00e1ng c\u1ee7a vi khu\u1ea9n, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb (th\u01b0\u1eddng \u0111i\u1ec1u tr\u1ecb l\u00e0 7 ng\u00e0y ho\u1eb7c c\u00f3 th\u1ec3 k\u00e9o d\u00e0i l\u00ean 14 ng\u00e0y), c\u00e1ch d\u00f9ng thu\u1ed1c ph\u00f9 h\u1ee3p v\u00e0 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi c\u00e1n b\u1ed9 nh\u00e2n vi\u00ean y t\u1ebf.<\/span><\/p>\n
Li\u1ec1u theo khuy\u1ebfn c\u00e1o:<\/span><\/p>\n\n\n\n\n\n\n
C\u00e2n n\u1eb7ng<\/td>\n Li\u1ec1u d\u00f9ng<\/td>\n<\/tr>\n
< 30kg<\/td>\n K\u1ebft h\u1ee3p v\u1edbi hai kh\u00e1ng sinh: d\u00f9ng \u0111\u1ed3ng th\u1eddi Nexium 10mg, amoxicillin 25mg\/kg c\u00e2n n\u1eb7ng v\u00e0 clarithromycin 7.5mg\/kg c\u00e2n n\u1eb7ng, 2 l\u1ea7n\/ng\u00e0y trong 1 tu\u1ea7n.<\/td>\n<\/tr>\n
30 – 40kg<\/td>\n K\u1ebft h\u1ee3p v\u1edbi hai kh\u00e1ng sinh: d\u00f9ng \u0111\u1ed3ng th\u1eddi Nexium 20mg, amoxicillin 750mg v\u00e0 clarithromycin 7.5mg\/kg c\u00e2n n\u1eb7ng, 2 l\u1ea7n\/ng\u00e0y trong 1 tu\u1ea7n.<\/td>\n<\/tr>\n
> 40kg<\/td>\n K\u1ebft h\u1ee3p v\u1edbi hai kh\u00e1ng sinh: d\u00f9ng \u0111\u1ed3ng th\u1eddi Nexium 20mg, amoxicillin 1g v\u00e0 clarithromycin 500mg, 2 l\u1ea7n\/ng\u00e0y trong 1 tu\u1ea7n.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Tr\u1ebb em d\u01b0\u1edbi 1 tu\u1ed5i<\/span><\/i><\/p>\n
Do ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c t\u00ednh an to\u00e0n v\u00e0 kinh nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb c\u00f2n h\u1ea1n ch\u1ebf n\u00ean hi\u1ec7n nay khuy\u1ebfn c\u00e1o kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c cho tr\u1ebb \u1edf \u0111\u1ed9 tu\u1ed5i n\u00e0y.<\/span><\/p>\n
Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean<\/span><\/i><\/p>\n
Xin xem th\u00eam th\u00f4ng tin k\u00ea toa c\u1ee7a thu\u1ed1c Nexium mups vi\u00ean n\u00e9n kh\u00e1ng d\u1ecbch d\u1ea1 d\u00e0y.<\/span><\/p>\n
\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/span><\/i><\/p>\n
Ng\u01b0\u1eddi b\u1ec7nh b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn<\/span><\/i><\/p>\n
Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn. Tuy nhi\u00ean v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn n\u1eb7ng n\u00ean th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c do hi\u1ec7n \u0111ang \u00edt kinh nghi\u1ec7m v\u1ec1 vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/span><\/p>\n
Ng\u01b0\u1eddi b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng gan<\/span><\/i><\/p>\n
\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n t\u1ed5n th\u01b0\u01a1ng gan m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn v\u1eeba, kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/span><\/p>\n
B\u1ec7nh nh\u00e2n 12 tu\u1ed5i tr\u1edf l\u00ean b\u1ecb suy gan n\u1eb7ng, li\u1ec1u d\u00f9ng t\u1ed1i \u0111a l\u00e0 20mg Nexium.<\/span><\/p>\n
Tr\u1ebb em 1-11 tu\u1ed5i b\u1ecb suy gan n\u1eb7ng, li\u1ec1u d\u00f9ng t\u1ed1i \u0111a l\u00e0 10mg.<\/span><\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Nexium 10mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n
Kh\u00f4ng s\u1eed d\u1ee5ng \u1edf nh\u1eefng tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m v\u1edbi c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c ho\u1eb7c ph\u00e2n nh\u00f3m benximidazol.<\/span><\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng Nexium 10mg n\u1ebfu ng\u01b0\u1eddi b\u1ec7nh \u0111ang d\u00f9ng thu\u1ed1c Nelfinavir.<\/span><\/p>\n
Kh\u00f4ng d\u00f9ng <\/span>nexium 10 mg cho tr\u1ebb s\u01a1 sinh<\/b> d\u01b0\u1edbi 1 tu\u00f4i.<\/span><\/p>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Nexium 10mg<\/span><\/h2>\n
Th\u1eadn tr\u1ecdng<\/span><\/h3>\n
Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c Nexium 10mg c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 gi\u1ea3m c\u00e2n \u0111\u00e1ng k\u1ec3 kh\u00f4ng ch\u00fa \u00fd, n\u00f4n t\u00e1i ph\u00e1t, kh\u00f3 nu\u1ed1t, n\u00f4n ra m\u00e1u hay \u0111\u1ea1i ti\u1ec7n ph\u00e2n \u0111en hay nghi ng\u1edd ho\u1eb7c b\u1ecb lo\u00e9t d\u1ea1 d\u00e0y n\u00ean lo\u1ea1i tr\u1eeb b\u1ec7nh l\u00fd \u00e1c t\u00ednh, t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm tr\u1ec5 vi\u1ec7c chu\u1ea9n \u0111o\u00e1n.<\/span><\/p>\n
N\u00ean theo d\u00f5i th\u01b0\u1eddng xuy\u00ean b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb h\u01a1n 1 n\u0103m. Th\u00f4ng th\u01b0\u1eddng \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb 12 tu\u1ed5i tr\u1edf l\u00ean.<\/span><\/p>\n
C\u1ea7n b\u00e1o c\u00e1o l\u1ea1i v\u1edbi b\u00e1c s\u0129 n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng thay \u0111\u1ed5i v\u1ec1 \u0111\u1eb7c t\u00ednh tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb theo ch\u1ebf \u0111\u1ed9 khi c\u1ea7n thi\u1ebft. \u0110i\u1ec1u tr\u1ecb theo ch\u1ebf \u0111\u1ed9 khi c\u1ea7n thi\u1ebft ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u1edf tr\u1ebb em, cho n\u00ean khuy\u1ebfn c\u00e1o ch\u01b0a \u0111\u01b0\u1ee3c d\u00f9ng \u1edf nh\u00f3m b\u1ec7nh n\u00e0y.<\/span><\/p>\n
X\u00e9t x\u00e9t k\u1ef9 l\u01b0\u1ee1ng nh\u1eefng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 x\u1ea3y ra trong qu\u00e1 tr\u00ecnh k\u00ea toa thu\u1ed1c esomeprazol theo ch\u1ebf \u0111\u1ed9 khi c\u1ea7n thi\u1ebft v\u00e0 n\u1ed3ng \u0111\u1ed9 esomeprazol trong huy\u1ebft t\u01b0\u01a1ng.<\/span><\/p>\n
C\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 v\u1ea5n \u0111\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p nh\u01b0 kh\u00f4ng dung n\u1ea1p fructose, k\u00e9m h\u1ea5p thu glucose – galactose ho\u1eb7c thi\u1ebfu sucrase – isomaltase kh\u00f4ng n\u00ean d\u00f9ng v\u00ec thu\u1ed1c c\u00f3 ch\u1ee9a \u0111\u01b0\u1eddng sucrose v\u00e0 glucose.<\/span><\/p>\n
Nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a nh\u01b0 salmonella v\u00e0 campylobacter c\u00f3 th\u1ec3 t\u0103ng nh\u1eb9 khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton. Kh\u00f4ng s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi esomeprazol v\u1edbi atazanavir. Trong tr\u01b0\u1eddng h\u1ee3p n\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p, c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd tr\u00ean l\u00e2m s\u00e0ng khi t\u0103ng li\u1ec1u atazanavir \u0111\u1ebfn 400mg k\u1ebft h\u1ee3p v\u1edbi 100mg ritonavir, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng qu\u00e1 20mg esomeprazol.<\/span><\/p>\n
Esomeprazol v\u00e0 c\u00e1c thu\u1ed1c kh\u00e1ng acid kh\u00e1ng c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng h\u1ea5p thu vitamin B12 do gi\u1ea3m acid d\u1ecbch v\u1ee5.<\/span><\/p>\n
Esomeprazol l\u00e0 thu\u1ed1c ho\u1ea1t \u0111\u1ed9ng v\u1edbi c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf CYP2C19, n\u00ean khi b\u1eaft \u0111\u1ea7u hay k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb v\u1edbi ho\u1ea1t ch\u1ea5t n\u00e0y c\u1ea7n xem x\u00e9t k\u1ef9 l\u01b0\u1ee1ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP2C19.<\/span><\/p>\n
V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n d\u1ef1 t\u00ednh \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i v\u1edbi PPI ho\u1eb7c s\u1eed d\u1ee5ng PPI v\u1edbi digitoxin hay thu\u1ed1c kh\u00e1c th\u1ec3 h\u1ea1 magnesi huy\u1ebft nh\u01b0 thu\u1ed1c l\u1ee3i ti\u1ec3u, c\u00e1c b\u00e1c s\u0129 c\u1ea7n ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 magnesi\u00a0 huy\u1ebft tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb\u00a0 v\u1edbi PPI v\u00e0 ki\u1ec3m tra \u0111\u1ecbnh k\u1ef3.<\/span><\/p>\n
C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng \u1edf li\u1ec1u cao v\u00e0 trong th\u1eddi gian d\u00e0i, c\u00f3 th\u1ec3 t\u0103ng nh\u1eb9 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng h\u00f4ng, x\u01b0\u01a1ng c\u1ed5 tay v\u00e0 c\u1ed9t s\u1ed1ng, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i ho\u1eb7c khi c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 \u0111\u00e3 bi\u1ebft kh\u00e1c.<\/span><\/p>\n
N\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng esomeprazol \u00edt nh\u1ea5t 5 ng\u00e0y tr\u01b0\u1edbc khi x\u00e9t nghi\u1ec7m CgA, v\u00ec n\u00f3 c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 Chromogranin A (CgA)d\u1eabn \u0111\u1ebfn vi\u1ec7c d\u00f2 t\u00ecm c\u00e1c kh\u1ed1i u th\u1ea7n kinh n\u1ed9i ti\u1ebft g\u1eb7p tr\u1edf ng\u1ea1i.\u00a0<\/span><\/p>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
C\u01a1 quan<\/td>\n Bi\u1ec3u hi\u1ec7n<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n m\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft<\/i><\/td>\n Hi\u1ebfm g\u1eb7p: gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n
R\u1ea5t hi\u1ebfm g\u1eb7p: m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n tai v\u00e0 m\u00ea \u0111\u1ea1o<\/i><\/td>\n Ch\u00f3ng m\u1eb7t<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n m\u1eaft<\/i><\/td>\n Nh\u00ecn m\u1edd<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/td>\n Th\u01b0\u1eddng g\u1eb7p: \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111\u1ea7y b\u1ee5ng, bu\u1ed3n n\u00f4n\/n\u00f4n<\/p>\n
\u00cdt g\u1eb7p: kh\u00f4 mi\u1ec7ng.<\/p>\n
Hi\u1ebfm g\u1eb7p: vi\u00eam mi\u1ec7ng, nhi\u1ec5m candida \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n
Ch\u01b0a bi\u1ebft: vi\u00eam \u0111\u1ea1i tr\u00e0ng vi th\u1ec3.<\/td>\n<\/tr>\n
C\u00e1c r\u1ed1i lo\u1ea1n t\u1ed5ng qu\u00e1t v\u00e0 t\u1ea1i ch\u1ed7<\/i><\/td>\n Hi\u1ebfm g\u1eb7p: kh\u00f3 \u1edf, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n gan m\u1eadt<\/i><\/td>\n \u00cdt g\u1eb7p: t\u0103ng men gan.<\/p>\n
Hi\u1ebfm g\u1eb7p: vi\u00eam gan c\u00f3 ho\u1eb7c kh\u00f4ng v\u00e0ng da.<\/p>\n
R\u1ea5t hi\u1ebfm: suy gan, b\u1ec7nh n\u00e3o \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e3 c\u00f3 b\u1ec7nh gan.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch<\/i><\/td>\n Hi\u1ebfm g\u1eb7p: ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nh\u01b0 l\u00e0 s\u1ed1t, ph\u00f9 m\u1ea1ch, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7\/s\u1ed1c ph\u1ea3n v\u1ec7.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng<\/i><\/td>\n \u00cdt g\u1eb7p: ph\u00f9 ngo\u1ea1i bi\u00ean.<\/p>\n
Hi\u1ebfm g\u1eb7p: gi\u1ea3m natri m\u00e1u.<\/p>\n
Ch\u01b0a bi\u1ebft: h\u1ea1 magnesi huy\u1ebft (xem m\u1ee5c \u201cl\u01b0u \u00fd v\u00e0 th\u1eadn tr\u1ecdng \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng\u201d), h\u1ea1 magnesi huy\u1ebft nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn h\u1ea1 canxi huy\u1ebft. H\u1ea1 magnesi huy\u1ebft c\u0169ng c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 kali huy\u1ebft.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n c\u01a1 x\u01b0\u01a1ng v\u00e0 m\u00f4 li\u00ean k\u1ebft<\/i><\/td>\n \u00cdt g\u1eb7p: g\u00e3y x\u01b0\u01a1ng h\u00f4ng, x\u01b0\u01a1ng c\u1ed5 tay ho\u1eb7c c\u1ed9t s\u1ed1ng (xem m\u1ee5c \u201cl\u01b0u \u00fd v\u00e0 th\u1eadn tr\u1ecdng \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng\u201d).<\/p>\n
Hi\u1ebfm g\u1eb7p: \u0111au kh\u1edbp, \u0111au c\u01a1.<\/p>\n
R\u1ea5t hi\u1ebfm: Y\u1ebfu c\u01a1<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh<\/i><\/td>\n Th\u01b0\u1eddng g\u1eb7p: nh\u1ee9c \u0111\u1ea7u.<\/p>\n
\u00cdt g\u1eb7p: cho\u00e1ng v\u00e1ng, d\u1ecb c\u1ea3m, ng\u1ee7 g\u00e0.<\/p>\n
Hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n<\/i><\/td>\n \u00cdt g\u1eb7p: m\u1ea5t ng\u1ee7.<\/p>\n
Hi\u1ebfm g\u1eb7p: k\u00edch \u0111\u1ed9ng, l\u00fa l\u1eabn, tr\u1ea7m c\u1ea3m.<\/p>\n
R\u1ea5t hi\u1ebfm: n\u00f3ng n\u1ea3y, \u1ea3o gi\u00e1c.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u<\/i><\/td>\n R\u1ea5t hi\u1ebfm: vi\u00eam th\u1eadn k\u1ebd, \u1edf m\u1ed9t v\u00e0i b\u1ec7nh nh\u00e2n suy th\u1eadn c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u0111\u1ed3ng th\u1eddi.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u1ec7 sinh s\u1ea3n v\u00e0 tuy\u1ebfn v\u00fa<\/i><\/td>\n R\u1ea5t hi\u1ebfm: n\u1eef h\u00f3a tuy\u1ebfn v\u00fa.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, ng\u1ef1c v\u00e0 trung th\u1ea5t<\/i><\/td>\n Hi\u1ebfm g\u1eb7p: co th\u1eaft ph\u1ebf qu\u1ea3n.<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da<\/i><\/td>\n \u00cdt g\u1eb7p: vi\u00eam da, ng\u1ee9a, n\u1ed5i m\u1ea9n, m\u1ec1 \u0111ay.<\/p>\n
Hi\u1ebfm g\u1eb7p: h\u00f3i \u0111\u1ea7u, nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng<\/p>\n
R\u1ea5t hi\u1ebfm: h\u1ed3ng ban \u0111a d\u1ea1ng, h\u1ed9i ch\u1ee9ng Stevens – Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec g\u00e2y \u0111\u1ed9c (TEN).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n
T\u00e1c \u0111\u1ed9ng c\u1ee7a esomeprazol tr\u00ean d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c<\/span><\/i><\/p>\n
Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng esomeprazol v\u00e0 c\u00e1c PPI, c\u00e1c t\u00ecnh tr\u1ea1ng gi\u1ea3m \u0111\u1ed9 axit d\u1ea1 d\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng hay gi\u1ea3m s\u1ef1 h\u1ea5p thu c\u00e1c thu\u1ed1c ph\u1ee5 thu\u1ed9c v\u00e0o pH d\u1ea1 d\u00e0y. S\u1ef1 h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c nh\u01b0 ketoconazol, itraconazol v\u00e0 erlotinib c\u00f3 th\u1ec3 gi\u1ea3m v\u00e0 s\u1ef1 h\u1ea5p thu c\u1ee7a digoxin c\u00f3 th\u1ec3 t\u0103ng l\u00ean trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi esomeprazol. Tuy nhi\u00ean \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi cao tu\u1ed5i c\u1ea7n th\u1eadn trong khi s\u1eed d\u1ee5ng esomeprazol li\u1ec1u cao. C\u1ea7n theo d\u00f5i c\u1ea9n trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng digoxin.<\/span><\/p>\n
M\u1ed9t s\u1ed1 b\u00e1o c\u00e1o r\u1eb1ng m\u1ed9t s\u1ed1 ch\u1ea5t \u1ee9c ch\u1ebf men protease c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi omeprazol.<\/span><\/p>\n
Ch\u1ec9 ph\u1ed1i h\u1ee3p khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft esomeprazol v\u1edbi thu\u1ed1c atazanavir.<\/span><\/p>\n
Nh\u1eefng thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP2C19<\/span><\/i><\/p>\n
Esomeprazol \u1ee9c ch\u1ebf CYP2C19 – men chuy\u1ec3n h\u00f3a ch\u00ednh esomeprazol, do v\u1eadt khi ph\u1ed1i h\u1ee3p n\u00f3 v\u1edbi c\u00e1c thu\u1ed1c diazepam, citalopram, imipramin, clomipramin, phenytoin…, c\u00f3 th\u1ec3 l\u00e0m n\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u00e1c thu\u1ed1c n\u00e0y t\u0103ng v\u00e0 c\u1ea7n gi\u1ea3m li\u1ec1u d\u00f9ng.<\/span><\/p>\n
N\u00ean theo d\u00f5i b\u1ec7nh nh\u00e2n khi b\u1eaft \u0111\u1ea7u v\u00e0 ng\u01b0ng c\u0169ng nh\u01b0 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi esomeprazol v\u1edbi warfarin ho\u1eb7c c\u00e1c d\u1eabn ch\u1ea5t kh\u00e1c c\u1ee7a coumarin.<\/span><\/p>\n
Ch\u01b0a bi\u1ebft c\u01a1 ch\u1ebf<\/span><\/i><\/p>\n
Khi ph\u1ed1i h\u1ee3p esomeprazol v\u1edbi c\u00e1c thu\u1ed1c tacrolimus c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u1ee7a thu\u1ed1c n\u00e0y.<\/span><\/p>\n
Khi ph\u1ed1i h\u1ee3p methotrexat c\u00f9ng v\u1edbi c\u00e1c PPI, \u0111\u00e3 c\u00f3 nghi\u00ean c\u1ee9u v\u1ec1 t\u0103ng n\u1ed3ng \u0111\u1ed9 methotrexat \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u00f9ng methotrexat li\u1ec1u cao, n\u00ean c\u00e2n nh\u1eafc t\u1ea1m th\u1eddi ng\u1eebng s\u1eed d\u1ee5ng esomeprazol.<\/span><\/p>\n
\u1ea2nh h\u01b0\u1edfng c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c tr\u00ean d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a esomeprazol<\/span><\/i><\/p>\n
CYP2C19 v\u00e0 CYP3A4 l\u00e0 2 enzym chuy\u1ec3n h\u00f3a c\u1ee7a Esomeprazol, v\u1eady n\u00ean khi ph\u1ed1i h\u1ee3p esomeprazol v\u1edbi m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4, clarithromycin (500mg, 2 l\u1ea7n\/ng\u00e0y) l\u00e0m t\u0103ng g\u1ea5p \u0111\u00f4i di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a esomeprazol. Khi ph\u1ed1i h\u1ee3p esomeprazol c\u00f9ng v\u1edbi m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u1ea3 hai CYP2C19 v\u00e0 CYP3A4 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng h\u01a1n hai l\u1ea7n n\u1ed3ng \u0111\u1ed9 v\u00e0 th\u1eddi gian ti\u1ebfp x\u00fac c\u1ee7a esomeprazol.<\/span><\/p>\n
N\u1ed3ng \u0111\u1ed9 esomeprazol huy\u1ebft thanh c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m b\u1edfi c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng CYP2C19 ho\u1eb7c CYP3A4 ho\u1eb7c c\u1ea3 hai (nh\u01b0 rifampicin v\u00e0 c\u1ecf St. John\u2019s) do t\u0103ng chuy\u1ec3n h\u00f3a.\u00a0<\/span><\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n
Hi\u1ec7n nay ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Nexium v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa v\u1eady n\u00ean ch\u1ec9 n\u00ean d\u00f9ng thu\u1ed1c khi c\u00f3 s\u1ef1 ch\u1ea5p thu\u1eadn c\u1ee7a b\u00e1c s\u0129.<\/span><\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n
Tri\u1ec7u ch\u1ee9ng<\/span><\/i>: khi d\u00f9ng v\u1edbi li\u1ec1u 280mg, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 b\u1ecb r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a ho\u1eb7c m\u1ec7t m\u1ecfi.\u00a0<\/span><\/p>\n
X\u1eed tr\u00ed:<\/span><\/i> Hi\u1ec7n nay ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. Esomeprazol g\u1eafn k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng n\u00ean ph\u01b0\u01a1ng ph\u00e1p th\u1ea9m t\u00e1ch kh\u00f3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, n\u00ean \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 t\u1ed5ng qu\u00e1t.<\/span><\/p>\n
Thu\u1ed1c Nexium 10mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n
Nexium 10mg gi\u00e1 bao nhi\u00eau<\/b> ? Thu\u1ed1c\u00a0 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n
K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:\u00a0\u00a0<\/span><\/p>\n
Thu\u1ed1c Stomagold<\/span><\/a> c\u00f3 ch\u1ee9a 40mg esomeprazol \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd d\u1ea1 d\u00e0y nh\u01b0 vi\u00eam lo\u00e9t, tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y,\u00a0 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Cure Medicines (I) Pvt Ltd-\u1ea4n \u0110\u1ed9. Hi\u1ec7n thu\u1ed1c \u0111ang \u0111\u01b0\u1ee3c b\u00e1n v\u1edbi gi\u00e1 136.000 \u0111\u1ed3ng\/ H\u1ed9p 3 v\u1ec9 x10 vi\u00ean.<\/span><\/p>\n
Thu\u1ed1c Lopioz<\/span><\/a> c\u00f3 ch\u1ee9a ho\u1ea1t ch\u1ea5t l\u00e0 omeprazol v\u1edbi h\u00e0m l\u01b0\u1ee3ng 20mg d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd \u0111\u01b0\u1eddng ti\u00eau h\u00f3a nh\u01b0 tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n, lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng,… \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t theo ti\u00eau chu\u1ea9n TCCS b\u1edfi S.C. Slavia Pharm S.R.L t\u1eeb Rumani. Hi\u1ec7n thu\u1ed1c \u0111ang \u0111\u01b0\u1ee3c b\u00e1n v\u1edbi gi\u00e1 240.000 \u0111\u1ed3ng\/ h\u1ed9p 30 vi\u00ean.<\/span><\/p>\n
T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Nexium 10mg?<\/span><\/h2>\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/td>\n Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n
Thu\u1ed1c nexium 10mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 esomeprazol – ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ea7u tay trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh v\u1ec1 d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n, \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 cao.<\/p>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c c\u1ed1m v\u1edbi h\u00e0m l\u01b0\u1ee3ng nh\u1ecf d\u1ec5 d\u00e0ng s\u1eed d\u1ee5ng tr\u00ean nhi\u1ec1u \u0111\u1ed1i t\u01b0\u1ee3ng v\u1edbi li\u1ec1u l\u01b0\u1ee3ng kh\u00e1c nhau.<\/p>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty AstraZeneca c\u00f3 quy tr\u00ecnh s\u1ea3n xu\u1ea5t quy m\u00f4, ti\u1ebfn ti\u1ebfn v\u00e0 \u0111\u1ea1t chu\u1ea9n GMP, n\u00ean c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u01b0a ra \u0111\u1ea3m b\u1ea3o v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng.<\/p>\n
Thu\u1ed1c c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng cho tr\u1ebb t\u1eeb 1 tu\u1ed5i tr\u1edf l\u00ean.<\/td>\n
Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c c\u00f3 th\u1ec3 x\u1ea3y ra m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng ph\u1ee5 v\u00e0 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 s\u1eed d\u1ee5ng theo \u0111\u00fang ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n
\n
\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi chuy\u00ean gia c\u1ee7a Pubchem. <\/span>Esomeprazole<\/span><\/i>. Th\u1eddi gian truy c\u1eadp <\/span>ng\u00e0y 4 th\u00e1ng 10 n\u0103m 2023, t\u1eeb https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Esomeprazole<\/span><\/a>.<\/span><\/li>\n
T\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Nexium 10mg, t\u1ea1i \u0111\u00e2y.<\/a><\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c nexium 10mg c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 esomeprazol – ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ea7u tay trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh v\u1ec1 d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n, c\u00f3 hi\u1ec7u qu\u1ea3 cao.<\/p>\n","protected":false},"author":490,"featured_media":46981,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-46970","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/46970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=46970"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/46981"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=46970"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=46970"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=46970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}