{"id":44855,"date":"2023-09-26T17:34:29","date_gmt":"2023-09-26T10:34:29","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=44855"},"modified":"2025-07-24T14:03:37","modified_gmt":"2025-07-24T07:03:37","slug":"hon-dich-nho-mat-azarga","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/hon-dich-nho-mat-azarga\/","title":{"rendered":"H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty S. A. Alcon, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-17810-14<\/b>.<\/span><\/p>\n

H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n

Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n

H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n m\u1ed7i ml d\u1ecbch l\u00e0<\/span><\/p>\n

Brinzolamid \u2026\u2026\u2026\u2026\u2026 10 mg<\/span><\/p>\n

Timolol maleat \u2026\u2026\u2026\u2026 6,8 mg t\u01b0\u01a1ng \u0111\u01b0\u01a1ng Timolol 5 mg<\/span><\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft.<\/span><\/p>\n

Tr\u00ecnh b\u00e0y<\/span><\/h3>\n

S\u0110K: VN-17810-14<\/span><\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd ch\u1ee9a 5ml h\u1ed7n d\u1ecbch.<\/span><\/p>\n

Xu\u1ea5t x\u1ee9: B\u1ec9<\/span><\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga\u00a0<\/span><\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n

Hai ho\u1ea1t ch\u1ea5t c\u00f3 trong h\u1ed7n d\u1ecbch nh\u1ecf thu\u1ed1c l\u00e0 brinzolamid v\u00e0 timolol maleat, \u0111\u1ec1u c\u00f3 t\u00e1c d\u1ee5ng gi\u00fap l\u00e0m gi\u1ea3m c\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng nh\u00e3n \u00e1p th\u00f4ng qua vi\u1ec7c gi\u1ea3m ti\u1ebft th\u1ee7y d\u1ecbch v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau. S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa c\u00e1c th\u00e0nh ph\u1ea7n n\u00e0y v\u1edbi nhau gi\u00fap th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh h\u1ea1 nh\u00e3n \u00e1p.<\/span><\/p>\n

Brinzolamid l\u00e0 ho\u1ea1t ch\u1ea5t ch\u1ed1ng carbonic anhydrase m\u1ea1nh (CA-II) \u1edf ng\u01b0\u1eddi m\u1ea1nh v\u00e0 iso-enzym n\u00e0y t\u1eadp chung ch\u1ee7 y\u1ebfu \u1edf v\u00f9ng m\u1eaft. Qu\u00e1 tr\u00ecnh ch\u1ed1ng carbonic anhydrase \u1edf tua mi m\u1eaft gi\u00fap h\u1ea1n ch\u1ebf s\u1ef1 ti\u1ebft th\u1ee7y d\u1ecbch v\u1edbi c\u01a1 ch\u1ebf l\u00e0m gi\u1ea3m s\u1ef1 t\u1ea1o th\u00e0nh\u00a0 ion bicarbonat qua \u0111\u00f3 \u1ee9c ch\u1ebf v\u1eadn chuy\u1ec3n natri v\u00e0 th\u1ee7y d\u1ecbch.<\/span><\/p>\n

Timolol Maleate l\u00e0 d\u1ea1ng mu\u1ed1i maleate c\u1ee7a timolol, m\u1ed9t d\u1eabn xu\u1ea5t propanolamine v\u00e0 l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng beta-adrenergic kh\u00f4ng ch\u1ecdn l\u1ecdc. <\/span>Timolol nh\u1ecf m\u1eaft <\/b>l\u00e0m gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n c\u00f3 th\u1ec3 b\u1eb1ng c\u00e1ch gi\u1ea3m s\u1ea3n xu\u1ea5t th\u1ee7y d\u1ecbch do gi\u1ea3m l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u0111\u1ebfn c\u00e1c th\u1ec3 mi v\u00e0 t\u1ed5ng h\u1ee3p cAMP.<\/span><\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n\n\n\n\n\n\n\n
\u0110\u1eb7c \u0111i\u1ec3m<\/td>\nBrinzolamid<\/td>\nTimolol<\/td>\n<\/tr>\n
H\u1ea5p thu<\/td>\nH\u1ea5p thu qua gi\u00e1c m\u1ea1c v\u00e0 v\u00e0o v\u00f2ng tu\u1ea7n ho\u00e0n chung<\/td>\n<\/tr>\n
Ph\u00e2n b\u1ed1<\/td>\nT\u1ec9 l\u1ec7 li\u00ean k\u1ebft protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a brinzolamid \u1edf m\u1ee9c trung b\u00ecnh (kho\u1ea3ng 60%).<\/p>\n

Brinzolamid t\u1eadp trung ch\u1ee7 y\u1ebfu trong t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u do thu\u1ed1c c\u00f3 \u00e1i l\u1ef1c cao, li\u00ean k\u1ebft v\u1edbi CA-II v\u00e0 \u1edf m\u1ee9c \u0111\u1ed9 \u00edt h\u01a1n l\u00e0 v\u1edbi CA-I.<\/p>\n

\u00c1i l\u1ef1c c\u1ee7a brinzolamid v\u00e0 ch\u1ea5t chuy\u1ec3n ho\u00e1 v\u1edbi t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u v\u00e0 c\u00e1c m\u00f4 CA d\u1eabn t\u1edbi thu\u1ed1c c\u00f3 n\u1ed3ng \u0111\u1ed9 th\u1ea5p trong huy\u1ebft t\u01b0\u01a1ng.<\/td>\n

Timolol c\u00f3 th\u1ec3 \u0111o \u0111\u01b0\u1ee3c trong thu\u1ef7 d\u1ecbch ng\u01b0\u1eddi sau khi d\u00f9ng dung d\u1ecbch nh\u1ecf m\u1eaft timolol v\u00e0 trong huy\u1ebft t\u01b0\u01a1ng cho t\u1edbi 12 gi\u1edd sau khi d\u00f9ng h\u1ed7n d\u1ecbch<\/td>\n<\/tr>\n
Chuy\u1ec3n h\u00f3a<\/td>\nCh\u1ea5t chuy\u1ec3n ho\u00e1 ch\u00ednh c\u1ee7a brinzolamid \u1edf ng\u01b0\u1eddi l\u00e0 N-desethyl brinzolamid, ch\u1ea5t n\u00e0y c\u0169ng li\u00ean k\u1ebft v\u1edbi CA-I khi c\u00f3 m\u1eb7t brinzolamid v\u00e0 t\u00edch lu\u1ef9 trong t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u.<\/td>\nTimolol \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 theo 2 \u0111\u01b0\u1eddng. M\u1ed9t \u0111\u01b0\u1eddng t\u1ea1o ra chu\u1ed7i ethanolamine tr\u00ean v\u00f2ng thiadiazol v\u00e0 \u0111\u01b0\u1eddng c\u00f2n l\u1ea1i t\u1ea1o ra chu\u1ed7i ethanolic tr\u00ean morpholin nitrogen v\u00e0 m\u1ed9t chu\u1ed7i th\u1ee9 hai t\u01b0\u01a1ng t\u1ef1 v\u1edbi nh\u00f3m carbonyl g\u1eafn v\u00e0o nitrogen.<\/p>\n

Timolol chuy\u1ec3n ho\u00e1 ch\u1ee7 y\u1ebfu nh\u1edd CYP2D6.<\/td>\n<\/tr>\n

Th\u1ea3i tr\u1eeb<\/td>\nTh\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua ph\u00e2n<\/td>\nTh\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn<\/p>\n

Kho\u1ea3ng 20% li\u1ec1u timolol \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i, ph\u1ea7n c\u00f2n l\u1ea1i d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n ho\u00e1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n

H\u1ed7n d\u1ecbch \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh trong \u0111i\u1ec1u tr\u1ecb gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n (IOP) b\u1ecb glocom g\u00f3c m\u1edf ho\u1eb7c t\u0103ng nh\u00e3n \u00e1p, m\u00e0 tr\u1ecb li\u1ec7u h\u1ea1 nh\u00e3n \u00e1p kh\u00f4ng hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c nh\u1ecf m\u1eaft Azarga\u00a0<\/span><\/h2>\n

Li\u1ec1u d\u00f9ng<\/span><\/h3>\n

Nh\u1ecf 1 gi\u1ecdt h\u1ed7n d\u1ecbch v\u00e0o t\u00fai k\u1ebft m\u1ea1c c\u1ee7a m\u1eaft b\u1ecb b\u1ec7nh 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/span><\/p>\n

C\u00e1ch d\u00f9ng:\u00a0<\/span><\/h3>\n

Thu\u1ed1c ch\u1ec9 d\u00f9ng l\u00e0m nh\u1ecf m\u1eaft.<\/span><\/p>\n

L\u1eafc k\u1ef9 l\u1ecd thu\u1ed1c tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/span><\/p>\n

Sau khi m\u1edf n\u1eafp, c\u1ea7n th\u00e1o b\u1ecf v\u00f2ng g\u1eafn \u0111\u1ea3m b\u1ea3o n\u1ebfu n\u00f3 b\u1ecb r\u1eddi ra.<\/span><\/p>\n

N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i d\u00f9ng ph\u1ed1i h\u1ee3p nhi\u1ec1u lo\u1ea1i thu\u1ed1c, n\u00ean s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c c\u00e1ch nhau \u00edt nh\u1ea5t 5 ph\u00fat \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 t\u1ed1i \u0111a.<\/span><\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c nh\u1ecf m\u1eaft Azarga trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n

Kh\u00f4ng d\u00f9ng <\/span>thu\u1ed1c nh\u1ecf m\u1eaft Azarga <\/b>trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c<\/span><\/p>\n

C\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 ti\u1ec1n s\u1eed m\u1eafc c\u00e1c b\u1ec7nh v\u1ec1 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p bao g\u1ed3m c\u1ea3 hen ph\u1ebf qu\u1ea3n, C\u00d4P, t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf m\u00e3n t\u00ednh n\u1eb7ng, vi\u00eam m\u0169i d\u1ecb \u1ee9ng n\u1eb7ng<\/span><\/p>\n

C\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eafc b\u1ec7nh v\u1ec1 nh\u1ecbp ch\u1eadm xoang, h\u1ed9i ch\u1ee9ng n\u00fat xoang, block xoang nh\u0129, block nh\u0129 th\u1ea5t \u0111\u1ed9 hai ho\u1eb7c ba, suy tim r\u00f5 r\u1ec7t ho\u1eb7c s\u1ed1c tim<\/span><\/p>\n

B\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng<\/span><\/p>\n

B\u1ec7nh nh\u00e2n b\u1ecb nhi\u1ec5m toan t\u0103ng clorid m\u00e1u<\/span><\/p>\n

Kh\u00f4ng d\u00f9ng cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i<\/span><\/p>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c nh\u1ecf m\u1eaft Azarga\u00a0<\/span><\/h2>\n

Th\u1eadn tr\u1ecdng<\/span><\/h3>\n

Th\u1eadn tr\u1ecdng chung<\/span><\/i><\/p>\n

Do h\u1ed7n d\u1ecbch \u0111\u01b0\u1ee3c h\u1ea5p th\u1ee5 to\u00e0n th\u00e2n, trong \u0111\u00f3 bao g\u1ed3m th\u00e0nh ph\u1ea7n timolol (thu\u1ed9c nh\u00f3m ch\u1eb9n beta-adrenergic) n\u00ean c\u00f3 th\u1ec3 x\u1ea3y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n tr\u00ean tim m\u1ea1ch, ph\u1ed5i trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng.<\/span><\/p>\n

C\u00f3 th\u1ec3 th\u1ec3 x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn hay g\u1eb7p v\u1edbi c\u00e1c d\u1eabn xu\u1ea5t sulphonamid n\u00ean c\u1ea7n ng\u01b0ng s\u1eed d\u1ee5ng n\u1ebfu x\u1ea3y ra c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a ph\u1ea3n \u1ee9ng\u00a0<\/span><\/p>\n

C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf carbonic anhydrase c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 hydrat h\u00f3a \u1edf gi\u00e1c m\u1ea1c g\u00e2y m\u1ea5t b\u00f9 v\u00e0 ph\u00f9 gi\u00e1c m\u1ea1c, n\u00ean c\u1ea7n theo d\u00f5i c\u1ea9n th\u1eadn v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb t\u1ed5n th\u01b0\u01a1ng gi\u00e1c m\u1ea1c.<\/span><\/p>\n

R\u1ed1i lo\u1ea1n tim<\/span><\/i><\/p>\n

V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch, huy\u1ebft \u00e1p n\u00ean \u0111\u00e1nh gi\u00e1 c\u1ea9n tr\u1ecdng v\u1edbi nh\u1eefng thu\u1ed1c ch\u1eb9n beta v\u00e0 c\u00e2n nh\u1eafc hi\u1ec7u ch\u1ec9nh li\u1ec1u v\u1edbi c\u00e1c ho\u1ea1t ch\u1ea5t kh\u00e1c.<\/span><\/p>\n

C\u1ea7n ki\u1ec3m so\u00e1t \u0111\u1ea7y \u0111\u1ee7 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng v\u1edbi timolol tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy tim.<\/span><\/p>\n

R\u1ed1i lo\u1ea1n m\u1ea1ch<\/span><\/i><\/p>\n

Nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n tu\u1ea7n ho\u00e0n ngo\u1ea1i bi\u00ean n\u1eb7ng nh\u01b0 nh\u1eefng d\u1ea1ng n\u1eb7ng c\u1ee7a b\u1ec7nh Raynaud ho\u1eb7c h\u1ed9i ch\u1ee9ng Raynaud c\u1ea7n ph\u1ea3i th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb thu\u1ed1c<\/span><\/p>\n

R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p<\/span><\/i><\/p>\n

M\u1ed9t s\u1ed1 b\u00e1o c\u00e1o \u0111\u00e3 cho r\u1eb1ng sau khi s\u1eed d\u1ee5ng m\u1ed9t s\u1ed1 thu\u1ed1c tra m\u1eaft ch\u1eb9n beta \u0111\u00e3 x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, c\u00f3 c\u1ea3 t\u1eed vong.<\/span><\/p>\n

H\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft\/ b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/span><\/i><\/p>\n

Do c\u00e1c thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 che d\u1ea5u c\u00e1c d\u1ea5u hi\u1ec7u, tri\u1ec7u ch\u1ee9ng c\u1ee7a h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ea5p t\u00ednh n\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00e1c thu\u1ed1c ch\u1eb9n beta cho nh\u1eefng b\u1ec7nh nh\u00e2n h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u1ef1 ph\u00e1t ho\u1eb7c \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/span><\/p>\n

C\u01b0\u1eddng gi\u00e1p<\/span><\/i><\/p>\n

C\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a b\u1ec7nh c\u01b0\u1eddng gi\u00e1p c\u00f3 th\u1ec3 b\u1ecb che d\u1ea5u b\u1edfi c\u00e1c thu\u1ed1c ch\u1eb9n beta.<\/span><\/p>\n

Y\u1ebfu c\u01a1<\/span><\/i><\/p>\n

C\u00e1c tri\u1ec7u ch\u1ee9ng y\u1ebfu c\u01a1 nh\u01b0 nh\u01b0\u1ee3c c\u01a1, song th\u1ecb, s\u1ee5p mi, y\u1ebfu to\u00e0n th\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u1ea1i sau khi s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1eb9n beta-adrenergic.<\/span><\/p>\n

C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf beta kh\u00e1c<\/span><\/i><\/p>\n

N\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd \u0111\u00e1p \u1ee9ng c\u1ee7a c\u00e1c b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c ch\u1eb9n beta \u0111\u01b0\u1eddng to\u00e0n th\u00e2n khi s\u1eed d\u1ee5ng timolol, do c\u00e1c t\u00e1c d\u1ee5ng tr\u00ean \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n ho\u1eb7c c\u00e1c t\u00e1c d\u1ee5ng ch\u1eb9n beta to\u00e0n th\u00e2n \u0111\u00e3 bi\u1ebft c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n. Theo khuy\u1ebfn c\u00e1o, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng hai thu\u1ed1c ch\u1eb9n beta-adrenergic t\u1ea1i ch\u1ed7.<\/span><\/p>\n

Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn<\/span><\/i><\/p>\n

C\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 th\u1ec3 x\u1ea3y ra m\u1ea1nh h\u01a1n khi s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1eb9n b\u00eat v\u1edbi ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m n\u1eb7ng v\u1edbi m\u1ed9t s\u1ed1 d\u1ecb nguy\u00ean.\u00a0<\/span><\/p>\n

G\u00e2y m\u00ea ph\u1eabu thu\u1eadt<\/span><\/i><\/p>\n

N\u00ean b\u00e1o c\u00e1o v\u1edbi b\u00e1c s\u0129 g\u00e2y m\u1eb9 khi s\u1eed d\u1ee5ng timolol do c\u00e1c thu\u1ed1c nh\u00e3n khoa ch\u1eb9n beta c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf c\u00e1c t\u00e1c d\u1ee5ng ch\u1ee7 v\u1eadn beta to\u00e0n th\u00e2n nh\u01b0 c\u1ee7a adrenalin.<\/span><\/p>\n

T\u00e1c d\u1ee5ng tr\u00ean m\u1eaft<\/span><\/i><\/p>\n

H\u01b0\u1edbng d\u1eabn c\u1ea9n th\u1eadn v\u00e0 chi ti\u1ebft v\u1ec1 c\u00e1ch s\u1eed d\u1ee5ng h\u1ed7n d\u1ecbch thu\u1ed1c nh\u1ecf m\u1eaft Azarga.\u00a0<\/span><\/p>\n

Thu\u1ed1c ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 khuy\u1ebfn c\u00e1o kh\u00f4ng d\u00f9ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb glomcom g\u00f3c h\u1eb9p.<\/span><\/p>\n

H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft AZARGA \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o tu\u1ea7n ho\u00e0n chung v\u00ec v\u1eady nh\u1eefng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng th\u1ef1c hi\u1ec7n nh\u1eefng ho\u1ea1t \u0111\u1ed9ng c\u1ea7n c\u00f3 s\u1ef1 t\u1ec9nh t\u00e1o \u0111\u1ea7u \u00f3c v\u00e0\/ho\u1eb7c ph\u1ed1i h\u1ee3p c\u00e1c \u0111\u1ed9ng t\u00e1c \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i.<\/span><\/p>\n

K\u00ednh \u00e1p tr\u00f2ng<\/span><\/i><\/p>\n

H\u1ed7n d\u1ecbch thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng v\u00e0 l\u00e0m \u0111\u1ed5i m\u00e0u k\u00ednh \u00e1p tr\u00f2ng m\u1ec1m, n\u00ean tr\u00e1nh ti\u1ebfp x\u00fac k\u00ednh \u00e1p tr\u00f2ng<\/span><\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c sau khi m\u1edf l\u1ecd 4 tu\u1ea7n.<\/span><\/p>\n

T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n

Khi s\u1eed d\u1ee5ng h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft AZARGA trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, lo\u1ea1n lo\u1ea1n v\u1ecb gi\u00e1c (c\u1ea3m gi\u00e1c b\u1ea5t th\u01b0\u1eddng ho\u1eb7c \u0111\u1eafng \u1edf mi\u1ec7ng sau khi nh\u1ecf thu\u1ed1c) l\u00e0 m\u1ed9t t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i to\u00e0n th\u00e2n th\u01b0\u1eddng \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3. Do thu\u1ed1c nh\u1ecf m\u1eaft ch\u1ea3y v\u00e0o m\u0169i h\u1ea7u th\u00f4ng qua \u1ed1ng m\u0169i l\u1ec7 v\u00e0 do brinzolamid g\u00e2y ra.<\/span><\/p>\n

Brinzolamid c\u00f3 trong h\u1ed7n d\u1ecbch\u00a0 nh\u1ecf m\u1eaft AZARGA l\u00e0 d\u1eabn ch\u1ea5t sulfonamid c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf carbonic anhydrase v\u00e0 h\u1ea5p thu v\u00e0o tu\u1ea7n ho\u00e0n chung. Nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n tr\u00ean h\u1ec7 ti\u00eau h\u00f3a, h\u1ec7 th\u1ea7n kinh, tu\u1ea7n ho\u00e0n, m\u00e1u, th\u00e2n v\u00e0 chuy\u1ec3n h\u00f3a khi d\u00f9ng ch\u1ea5t \u1ee9c ch\u1ebf carbonic anhydrase \u0111\u01b0\u1eddng to\u00e0n th\u00e2n ho\u1eb7c t\u1ea1i ch\u1ed7.<\/span><\/p>\n

M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra nh\u01b0 sau<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Ph\u00e2n lo\u1ea1i h\u1ec7 c\u01a1 quan<\/b><\/td>\nT\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i<\/b>
\n<\/b>(thu\u1eadt ng\u1eef c\u1ee7a MedDRA<\/b><\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch<\/td>\nS\u1ed1c ph\u1ea3n v\u00ea, m\u1eabn c\u1ea3m<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n tim<\/td>\n\u0110\u00e1nh tr\u1ed1ng ng\u1ef1c<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n tai v\u00e0 m\u00ea \u0111\u1ea1o<\/td>\n\u00d9 tai<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n<\/td>\nTr\u1ea7m c\u1ea3m<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh<\/td>\nCh\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, d\u1ecb c\u1ea3m<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n m\u1eaft<\/td>\nD\u1ecb \u1ee9ng m\u1eaft, ph\u00f9 m\u00ed m\u1eaft, suy gi\u1ea3m th\u1ecb l\u1ef1c, vi\u00eam k\u1ebft m\u1ea1c<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n m\u1ea1ch<\/td>\nT\u0103ng huy\u1ebft \u00e1p<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, l\u1ed3ng ng\u1ef1c v\u00e0 trung th\u1ea5t<\/td>\nHen, kh\u00f3 th\u1edf, ch\u1ea3y m\u00e1u cam<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/td>\n\u0110au b\u1ee5ng, ti\u00eau ch\u1ea3y, kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n<\/td>\n<\/tr>\n
Da v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c d\u01b0\u1edbi da<\/td>\nR\u1ee5ng t\u00f3c, ban \u0111\u1ecf ph\u00e1t ban, ng\u1ee9a<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n c\u01a1 v\u00e0 c\u00e1c m\u00f4 li\u00ean k\u1ebft<\/td>\n\u0110au c\u01a1<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n to\u00e0n th\u00e2n v\u00e0 t\u1ea1i ch\u1ed7 d\u00f9ng thu\u1ed1c<\/td>\n\u0110au ng\u1ef1c, m\u1ec7t m\u1ecfi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n

C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 nh\u01b0 ketoconazol, itraconazol, clotrimazol, ritornavir v\u00e0 troleandomycin \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a brinzolamid b\u1eb1ng CYP3A4.<\/span><\/p>\n

C\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng tr\u00ean c\u00e1c t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n \u0111\u00e3 bi\u1ebft c\u1ee7a c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 thu\u1ed1c nh\u1ecf m\u1eaft brinzolamid. Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c nh\u1ecf m\u1eaft c\u00f3 ch\u1ee9a brinzolamid v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase \u0111\u01b0\u1eddng u\u1ed1ng.<\/span><\/p>\n

Ph\u1ea3n \u1ee9ng t\u0103ng huy\u1ebft \u00e1p khi ng\u1eebng clonidin \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 tr\u1ea7m tr\u1ecdng h\u01a1n khi \u0111ang s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1eb9n beta.\u00a0<\/span><\/p>\n

Nguy c\u01a1 x\u1ea3y ra t\u00e1c d\u1ee5ng ch\u1eb9n beta to\u00e0n th\u00e2n (nh\u01b0 gi\u1ea3m nh\u1ecbp tim, tr\u1ea7m c\u1ea5m) \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi k\u1ebft h\u1ee3p \u0111i\u1ec1u tr\u1ecb thu\u1ed1c \u1ee9c ch\u1ebf CYP2D6 (nh\u01b0 quinidin, fluoxetin, paroxetin) v\u00e0 timolol.\u00a0<\/span><\/p>\n

C\u00e1c thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/span><\/p>\n

C\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng d\u1eabn t\u1edbi h\u1ea1 huy\u1ebft \u00e1p v\u00e0\/ho\u1eb7c ch\u1eadm nh\u1ecbp tim \u0111\u00e1ng k\u1ec3 khi d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c dung d\u1ecbch nh\u1ecf m\u1eaft ch\u1eb9n beta v\u1edbi c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci, ch\u1eb9n beta-adrenergic, c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp (bao g\u1ed3m amiodaron), ho\u1eb7c glycosid tim lo\u1ea1i digitalis, c\u00e1c thu\u1ed1c gi\u1ea3 c\u01b0\u1eddng giao c\u1ea3m \u0111\u01b0\u1eddng u\u1ed1ng.<\/span><\/p>\n

Gi\u00e3n \u0111\u1ed3ng t\u1eed do s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c tra m\u1eaft ch\u1eb9n beta v\u00e0 adrenalin (epinephrin) \u0111\u1ed7i khi \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o.\u00a0<\/span><\/p>\n

C\u00e1c thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1p \u1ee9ng v\u1edbi adrenalin \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn. C\u1ea7n \u0111\u1eb7c bi\u1ec7t th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng ho\u1eb7c s\u1ed1c ph\u1ea3n v\u1ec7.<\/span><\/p>\n

L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n

Thu\u1ed1c kh\u00f4ng n\u00ean d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa do ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u ch\u1ee9ng minh t\u00ednh an to\u00e0n khi s\u1eed d\u1ee5ng tr\u00ean nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/span><\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n

Trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng may nu\u1ed1t ph\u1ea3i thu\u1ed1c, c\u00e1c tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u nh\u01b0 h\u1ea1 huy\u1ebft \u00e1p, nh\u1ecbp tim ch\u1eadm, suy tim v\u00e0 co th\u1eaft ph\u1ebf qu\u1ea3n c\u00f3 th\u1ec3 x\u1ea3y ra.<\/span><\/p>\n

Do brinzolamid, c\u00e1c t\u00ecnh tr\u1ea1ng m\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i, ti\u1ebfn tri\u1ec3n t\u1edbi nhi\u1ec5m toan m\u00e1u v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng tr\u00ean h\u1ec7 th\u1ea7n kinh c\u00f3 th\u1ec3 x\u1ea3y ra. C\u1ea7n theo d\u00f5i \u0111i\u1ec7n gi\u1ea3i huy\u1ebft thanh \u0111\u1eb7c bi\u1ec7t l\u00e0 kali m\u00e1u v\u00e0 pH m\u00e1u.<\/span><\/p>\n

Thu\u1ed1c nh\u1ecf m\u1eaft Azarga 5ml gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n

H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft <\/span>Azarga gi\u00e1 bao nhi\u00eau<\/b> ? Hi\u1ec7n thu\u1ed1c \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n

K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:\u00a0\u00a0<\/span><\/p>\n

Thu\u1ed1c Duotrav<\/span><\/a> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 travoprost, timolol maleat gi\u00fap \u0111i\u1ec1u tr\u1ecb\u00a0 gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n c\u1ea7u (IOP) \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n glaucom g\u00f3c m\u1edf hay trong tr\u01b0\u1eddng h\u1ee3p t\u0103ng \u00e1p l\u1ef1c nh\u00e3n c\u1ea7u, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty S.A Alcon Couvreur N.V \u2013 B\u1ec9. Hi\u1ec7n thu\u1ed1c <\/span>Duotrav <\/b>\u0111ang \u0111\u01b0\u1ee3c b\u00e1n v\u1edbi gi\u00e1 360.000 \u0111\u1ed3ng\/ h\u1ed9p 1 l\u1ecd 2,5 ml.<\/span><\/p>\n

Thu\u1ed1c Combigan<\/span><\/a> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n natri phosphat dibasic heptahydrat, benzalkonium clorid, acid hydrocloric, gi\u00fap \u0111i\u1ec1u tr\u1ecb b\u1ec7nh v\u1ec1 m\u1eaft v\u1edbi t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m \u0111i \u00e1p l\u1ef1c \u1edf n\u1ed9i nh\u00e3n, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi h\u00e3ng Allergan t\u1ea1i Iceland. Hi\u1ec7n<\/span> thu\u1ed1c nh\u1ecf m\u1eaft Combigan <\/b>\u0111ang \u0111\u01b0\u1ee3c b\u00e1n v\u1edbi gi\u00e1 300.000 \u0111\u1ed3ng\/ h\u1ed9p 1 l\u1ecd 5ml.<\/span><\/p>\n

T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga ?<\/span><\/h2>\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/td>\nNh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n
Thu\u1ed1c nh\u1ecf m\u1eaft Azarga c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n Brinzolamid v\u00e0 Timolol gi\u00fap \u0111i\u1ec1u tr\u1ecb gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n (IOP) b\u1ecb glocom g\u00f3c m\u1edf ho\u1eb7c t\u0103ng nh\u00e3n \u00e1p, m\u00e0 tr\u1ecb li\u1ec7u h\u1ea1 nh\u00e3n \u00e1p kh\u00f4ng hi\u1ec7u qu\u1ea3.<\/p>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m S. A. Alcon – B\u1ec9 \u0111\u1ea1t chu\u1ea9n quy tr\u00ecnh s\u1ea3n xu\u1ea5t GMP – Ch\u00e2u \u00c2u, n\u00ean uy t\u00edn, s\u1ea3n ph\u1ea9m \u0111\u1ea1t ch\u1ea5t l\u01b0\u1ee3ng.<\/p>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf \u1edf d\u1ea1ng dung d\u1ecbch nh\u1ecf m\u1eaft, l\u00e0 d\u1ea1ng d\u00f9ng ph\u1ed5 bi\u1ebfn v\u1edbi c\u00e1ch d\u00f9ng \u0111\u01a1n gi\u1ea3n v\u00e0 hi\u1ec7u qu\u1ea3.<\/td>\n

Thu\u1ed1c kh\u00f4ng d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 18 tu\u1ed5i.<\/p>\n

Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng v\u00e0 c\u00f3 th\u1ec3 c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u thu\u1ed1c khi ph\u1ed1i h\u1ee3p c\u00f9ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n
    \n
  1. \u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi chuy\u00ean gia Pubchem. <\/span>Timolol maleat<\/span><\/i>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 26 th\u00e1ng 9 n\u0103m 2023, t\u1eeb <\/span>https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Timolol-maleate<\/span><\/a><\/li>\n
  2. \u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi chuy\u00ean gia Pubchem. <\/span>Brinzolamid<\/span><\/i>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 26 th\u00e1ng 9 n\u0103m 2023, t\u1eeb <\/span>https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Brinzolamide<\/span><\/a><\/li>\n
  3. T\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga, t\u1ea1i \u0111\u00e2y.<\/a><\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    H\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft Azarga c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n Timolol maleat, Brinzolamid \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n, b\u1ecb glocom g\u00f3c m\u1edf ho\u1eb7c t\u0103ng nh\u00e3n \u00e1p, m\u00e0 li\u1ec1u \u0111i\u1ec1u tr\u1ecb kh\u00f4ng hi\u1ec7u qu\u1ea3<\/p>\n","protected":false},"author":490,"featured_media":44864,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-44855","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/44855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=44855"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/44864"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=44855"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=44855"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=44855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}