{"id":42653,"date":"2023-09-16T14:27:27","date_gmt":"2023-09-16T07:27:27","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=42653"},"modified":"2025-07-24T14:03:46","modified_gmt":"2025-07-24T07:03:46","slug":"dutasvitae-0-5mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/dutasvitae-0-5mg\/","title":{"rendered":"Dutasvitae 0.5mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/dutasvitae-0-5mg\/\">Dutasvitae 0.5mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi CYNDEA PHARMA, S.L-T\u00e2y Ban Nha, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-22876-21<\/strong><\/p>\n<h2>Dutasvitae 0.5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Dutasvitae 0.5mg<\/strong> ch\u1ee9a:<br \/>\nHo\u1ea1t ch\u1ea5t: Dutasteride\u20260,5 mg.<br \/>\nT\u00e1 d\u01b0\u1ee3c Butylhydroxytoluene (E321), Glycerol monocaprylocaprate (type I), Triglyceride medium chain, Gelatin, Glycerol, Titan dioxide (El71), Lecithin (E322), M\u00e0u v\u00e0ng oxit s\u1eaft (El 72), n\u01b0\u1edbc tinh khi\u1ebft.<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang m\u1ec1m.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-22876-21.<br \/>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean.<br \/>\nXu\u1ea5t x\u1ee9: T\u00e2y Ban Nha.<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Dutasvitae 0.5mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Dutasteride t\u00e1c \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf enzyme 5-alpha reductase lo\u1ea1i 1 v\u00e0 lo\u1ea1i 2 &#8211; c\u00f3 vai tr\u00f2 chuy\u1ec3n testosterone th\u00e0nh 5-alpha-DHT, d\u1eabn \u0111\u1ebfn l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 dihydrotestosterone (DHT) tu\u1ea7n ho\u00e0n.<\/p>\n<p>S\u1eed d\u1ee5ng Dutasvitae 0.5mg \u0111\u01a1n tr\u1ecb li\u1ec7u c\u00f3 nh\u1eefng t\u00e1c d\u1ee5ng sau:<\/p>\n<ul>\n<li>L\u00e0m gi\u1ea3m DHT\/ Testosteron:<\/li>\n<\/ul>\n<p>V\u1edbi li\u1ec1u Dutasteride 0,5mg\/ng\u00e0y trong v\u00f2ng 1-2 tu\u1ea7n, c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m dihydrotestosteron (DHT) (tu\u1ea7n 1: gi\u1ea3m 85% v\u00e0 tu\u1ea7n 2: gi\u1ea3m 90%) v\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng.<br \/>\nB\u1ec7nh nh\u00e2n ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t (BPH) d\u00f9ng Dutasteride 0,5 mg\/ng\u00e0y, cho th\u1ea5y:<br \/>\nN\u0103m 1 gi\u1ea3m trung b\u00ecnh 94% n\u1ed3ng \u0111\u1ed9 dihydrotestosteron (DHT) trong huy\u1ebft thanh l\u00e0 94% v\u00e0 93% \u1edf n\u0103m 2.<br \/>\n\u1ede c\u1ea3 n\u0103m th\u1ee9 nh\u1ea5t v\u00e0 n\u0103m 2, t\u0103ng trung b\u00ecnh 19% testosteron trong huy\u1ebft thanh.<\/p>\n<ul>\n<li>Gi\u1ea3m k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t:<\/li>\n<\/ul>\n<p>Tr\u01b0\u1eddng h\u1ee3p ph\u00e1t hi\u1ec7n s\u1edbm m\u1ed9t th\u00e1ng sau kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb cho th\u1ea5y gi\u1ea3m \u0111\u00e1ng k\u1ec3 k\u00edch th\u01b0\u1edbc ti\u1ec1n li\u1ec7t tuy\u1ebfn v\u00e0 ti\u1ebfp t\u1ee5c gi\u1ea3m \u0111\u1ebfn th\u00e1ng 24 (p &lt;0,001).<\/p>\n<p>So v\u1edbi nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c ch\u1ec9 gi\u1ea3m trung b\u00ecnh k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0 0,5%, Dutasteride l\u00e0m gi\u1ea3m trung b\u00ecnh 23,6% k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t \u1edf th\u00e1ng 12.<\/p>\n<p>\u1ede th\u00e1ng 12, nh\u00f3m d\u00f9ng Dutasteride c\u00f3 s\u1ef1 gi\u1ea3m \u0111\u00e1ng k\u1ec3 (p &lt;0,001) k\u00edch th\u01b0\u1edbc v\u00f9ng chuy\u1ec3n ti\u1ebfp c\u1ee7a tuy\u1ebfn ti\u1ec1n 17,8% so v\u1edbi m\u1ee9c t\u0103ng trung b\u00ecnh 7,9% trong nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n<p>Trong 2 n\u0103m \u0111\u1ea7u c\u1ee7a \u0111i\u1ec1u tr\u1ecb m\u00f9 \u0111\u00f4i \u0111\u00e3 th\u1ea5y gi\u1ea3m k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng s\u1ebd \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n v\u00e0 gi\u1ea3m nguy c\u01a1 ph\u1eabu thu\u1eadt AUR v\u00e0 BPH n\u1ebfu k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t gi\u1ea3m.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Sau 1-3 gi\u1edd u\u1ed1ng m\u1ed9t li\u1ec1u duy nh\u1ea5t Dutasteride 0,5mg, n\u1ed3ng \u0111\u1ed9 Dutasteride trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u1ec9nh. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 60% v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n.<\/p>\n<p>Ph\u00e2n b\u1ed1: Dutasteride c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn &gt; 99,5% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn (t\u1eeb 300 \u0111\u1ebfn 500 l\u00edt). N\u1ed3ng \u0111\u1ed9 Dutasteride trong huy\u1ebft thanh \u0111\u1ea1t 65% sau khi d\u00f9ng li\u1ec1u h\u00e0ng ng\u00e0y, so v\u1edbi n\u1ed3ng \u0111\u1ed9 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau 1 th\u00e1ng v\u00e0 sau 3 th\u00e1ng l\u00e0 kho\u1ea3ng 90%.<br \/>\nSau 6 th\u00e1ng d\u00f9ng li\u1ec1u 0.5 mg\/l\u1ea7n\/ng\u00e0y n\u1ed3ng \u0111\u1ed9 huy\u1ebft thanh \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (Css) kho\u1ea3ng 40 ng\/mL. C\u00f3 kho\u1ea3ng 11,5% Dutasteride ph\u00e2n chia t\u1eeb huy\u1ebft thanh v\u00e0o tinh d\u1ecbch.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Trong in vitro, Dutasteride chuy\u1ec3n h\u00f3a th\u00e0nh ba ch\u1ea5t chuy\u1ec3n h\u00f3a monohydroxylat v\u00e0 m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a dihydroxylat b\u1edfi cytochrome P450 3A4 v\u00e0 3A5.<br \/>\nC\u00f3 1-15,4% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft trong ph\u00e2n d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i sau khi u\u1ed1ng Dutasteride 0,5 mg\/ng\u00e0y \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh. Ph\u1ea7n c\u00f2n l\u1ea1i b\u00e0i ti\u1ebft qua ph\u00e2n g\u1ed3m 4 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu l\u00e0 39%, 21%, 7%, v\u00e0 7% m\u1ed7i nguy\u00ean li\u1ec7u li\u00ean quan \u0111\u1ebfn thu\u1ed1c v\u00e0 6 ch\u1ea5t chuy\u00ean h\u00f3a nh\u1ecf (\u00edt h\u01a1n 5% m\u1ed7i lo\u1ea1i). Ch\u1ec9 c\u00f3 l\u01b0\u1ee3ng nh\u1ecf Dutasteride d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i (\u00edt h\u01a1n 0,1%) \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<p>Dutasteride th\u1ea3i tr\u1eeb qua hai \u0111\u01b0\u1eddng song song: \u0111\u01b0\u1eddng b\u00e3o h\u00f2a t\u1ea1i n\u1ed3ng \u0111\u1ed9 l\u00e2m s\u00e0ng c\u00f3 li\u00ean quan v\u00e0 \u0111\u01b0\u1eddng kh\u00f4ng b\u00e3o h\u00f2a. S\u1ef1 th\u1ea3i tr\u1eeb ph\u1ee5 thu\u1ed9c li\u1ec1u.<br \/>\nDutasteride th\u1ea3i tr\u1eeb nhanh \u1edf n\u1ed3ng \u0111\u1ed9 huy\u1ebft thanh th\u1ea5p (d\u01b0\u1edbi 3 ng\/ml). \u0110\u1ed1i v\u1edbi c\u00e1c li\u1ec1u \u0111\u01a1n 5mg ho\u1eb7c \u00edt h\u01a1n cho th\u1ea5y \u0111\u1ed9 thanh th\u1ea3i nhanh v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i ng\u1eafn (3-9 ng\u00e0y).<br \/>\nLi\u1ec1u l\u1eb7p l\u1ea1i 0,5 mg\/ng\u00e0y, \u0111\u01b0\u1eddng th\u1ea3i tr\u1eeb tuy\u1ebfn t\u00ednh chi\u1ebfm \u01b0u th\u1ebf v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 3-5 tu\u1ea7n.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i:<br \/>\nNghi\u00ean c\u1ee9u cho th\u1ea5y, tu\u1ed5i t\u00e1c kh\u00f4ng c\u00f3 s\u1ef1 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 khi ti\u1ebfp x\u00fac v\u1edbi Dutasteride, tuy nhi\u00ean th\u1eddi gian b\u00e1n th\u1ea3i ng\u1eafn h\u01a1n \u1edf nam gi\u1edbi d\u01b0\u1edbi 50 tu\u1ed5i.<\/p>\n<p>Suy th\u1eadn:<br \/>\nCh\u01b0a c\u00f3 nghi\u00ean c\u1ee9u v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Dutasteride tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn. Tuy nhi\u00ean kh\u00f4ng th\u1ea5y s\u1ef1 t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Dutasteride trong huy\u1ebft t\u01b0\u01a1ng v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng d\u1ef1 \u0111o\u00e1n cho b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p>Suy gan:<br \/>\nD\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Dutasteride \u1edf b\u1ec7nh nh\u00e2n suy gan ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. V\u00ec Dutasteride th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu th\u00f4ng qua chuy\u1ec3n h\u00f3a n\u00ean n\u1ed3ng \u0111\u1ed9 Dutasteride trong huy\u1ebft t\u01b0\u01a1ng d\u1ef1 ki\u1ebfn s\u1ebd t\u0103ng v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i s\u1ebd k\u00e9o d\u00e0i.<\/p>\n<h2>Thu\u1ed1c Dutasvitae 0.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>B\u1ec7nh t\u0103ng s\u1ea3n tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh (BPH) t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng: thu\u1ed1c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/li>\n<li>L\u00e0m gi\u1ea3m nguy c\u01a1 x\u1ea3y ra b\u00ed ti\u1ec3u c\u1ea5p t\u00ednh (AUR).<\/li>\n<li>\u1ede b\u1ec7nh nh\u00e2n c\u00f3 tri\u1ec7u ch\u1ee9ng t\u0103ng s\u1ea3n tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh (BPH) t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng, gi\u00fap l\u00e0m gi\u1ea3m nguy c\u01a1 c\u1ea7n ph\u1eabu thu\u1eadt.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Dutasvitae 0.5mg<\/h2>\n<p>C\u00e1ch d\u00f9ng: Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng theo \u0111\u01b0\u1eddng u\u1ed1ng. Ch\u00fa \u00fd: U\u1ed1ng nguy\u00ean vi\u00ean, \u0111\u1ec3 tr\u00e1nh thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng ni\u00eam m\u1ea1c h\u1ea7u h\u1ecdng kh\u00f4ng nhai ho\u1eb7c m\u1edf n\u1eafp. C\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng v\u1edbi b\u1eefa \u0103n.<br \/>\nC\u00f3 th\u1ec3 d\u00f9ng ri\u00eang Dutasvitae 0.5 mg ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi alpha-blocker tamsulosin 0,4mg.<\/p>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 32.2168%;text-align: center\" colspan=\"2\">\u0110\u1ed1i t\u01b0\u1ee3ng<\/td>\n<td style=\"width: 67.7831%;text-align: center\">Li\u1ec1u d\u00f9ng<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 32.2168%\" colspan=\"2\">Ng\u01b0\u1eddi l\u1edbn (k\u1ec3 c\u1ea3 ng\u01b0\u1eddi cao tu\u1ed5i)<\/td>\n<td style=\"width: 67.7831%\">Khuy\u1ebfn c\u00e1o 1 vi\u00ean\/ng\u00e0y. C\u00f3 th\u1ec3 ph\u1ea3i m\u1ea5t 6 th\u00e1ng m\u1edbi \u0111\u1ea1t \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb.<br \/>\nNg\u01b0\u1eddi cao tu\u1ed5i kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.6906%\" rowspan=\"2\">B\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t<\/td>\n<td style=\"width: 10.5262%\">Suy th\u1eadn<\/td>\n<td style=\"width: 67.7831%\">Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 10.5262%\">Suy gan<\/td>\n<td style=\"width: 67.7831%\">Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<br \/>\nB\u1ec7nh nh\u00e2n suy gan n\u1eb7ng kh\u00f4ng s\u1eed d\u1ee5ng Dutasteride<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Dutasvitae 0.5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Dutasvitae kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n<ul>\n<li>Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean.<\/li>\n<li>Ph\u1ee5 n\u1eef.<\/li>\n<li>B\u1ec7nh nh\u00e2n m\u1eabn c\u1ea3m v\u1edbi Dutasteride v\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf 5-alpha reductase ho\u1eb7c b\u1ea5t k\u1ef3 lo\u1ea1i t\u00e1 d\u01b0\u1ee3c kh\u00e1c c\u00f3 trong c\u00f4ng th\u1ee9c.<\/li>\n<li>B\u1ec7nh nh\u00e2n d\u1ecb \u1ee9ng v\u1edbi \u0111\u1eadu n\u00e0nh, \u0111\u1eadu ph\u1ed9ng.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Dutasvitae 0.5mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Sau khi \u0111\u00e1nh gi\u00e1 nguy c\u01a1 &#8211; l\u1ee3i \u00edch c\u1ea9n th\u1eadn v\u00e0 sau khi xem x\u00e9t c\u00e1c ph\u01b0\u01a1ng \u00e1n \u0111i\u1ec1u tr\u1ecb thay th\u1ebf (bao g\u1ed3m c\u1ea3 c\u00e1c li\u1ec7u ph\u00e1p \u0111\u01a1n tr\u1ecb li\u1ec7u) th\u00ec n\u00ean k\u00ea \u0111\u01a1n \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p.<\/p>\n<p>Suy tim: Trong hai nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng k\u00e9o d\u00e0i 4 n\u0103m, trong s\u1ed1 nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng ph\u1ed1i h\u1ee3p Dutasteride v\u1edbi thu\u1ed1c ch\u1eb9n alpha (ch\u1ee7 y\u1ebfu l\u00e0 tamsulosin) th\u00ec t\u1ef7 l\u1ec7 b\u1ecb suy tim cao h\u01a1n c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng d\u00f9ng ph\u1ed1i h\u1ee3p thu\u1ed1c. Trong hai th\u1eed nghi\u1ec7m n\u00e0y, t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh tim m\u1ea1ch th\u1ea5p (&lt; 1%) v\u00e0 thay \u0111\u1ed5i gi\u1eefa c\u00e1c nghi\u00ean c\u1ee9u.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng \u0111\u1ed1i v\u1edbi kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u tuy\u1ebfn ti\u1ec1n li\u1ec7t (PSA) v\u00e0 ph\u00e1t hi\u1ec7n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t:<\/p>\n<ul>\n<li>B\u1ec7nh nh\u00e2n t\u0103ng s\u1ea3n tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh (BPH), tr\u01b0\u1edbc khi kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi Dutasteride c\u1ea7n ki\u1ec3m tra tr\u1ef1c tr\u00e0ng b\u1eb1ng k\u1ef9 thu\u1eadt s\u1ed1 v\u00e0 th\u1ef1c hi\u1ec7n c\u00e1c \u0111\u00e1nh gi\u00e1 kh\u00e1c \u0111\u1ed1i v\u1edbi ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t. Sau \u0111\u00f3 c\u0169ng c\u1ea7n ki\u1ec3m tra \u0111\u1ecbnh k\u1ef3.<\/li>\n<li>\u0110\u1ec3 ph\u00e1t hi\u1ec7n ung th\u01b0 ti\u1ec1n li\u1ec7t tuy\u1ebfn c\u1ea7n d\u1ef1a v\u00e0o n\u1ed3ng \u0111\u1ed9 kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u tuy\u1ebfn ti\u1ec1n li\u1ec7t trong huy\u1ebft thanh (PSA). Sau 6 th\u00e1ng \u0111i\u1ec1u tr\u1ecb, Dutasteride l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 PSA huy\u1ebft thanh trung b\u00ecnh kho\u1ea3ng 50%.<\/li>\n<li>B\u1ec7nh nh\u00e2n n\u00ean thi\u1ebft l\u1eadp l\u1ea1i m\u1ee9c PSA c\u01a1 b\u1ea3n m\u1edbi sau 6 th\u00e1ng d\u00f9ng Dutasteride 0.5mg. Theo d\u00f5i n\u1ed3ng \u0111\u1ed9 PSA th\u01b0\u1eddng xuy\u00ean sau \u0111\u00f3, n\u1ebfu th\u1ea5y t\u0103ng x\u00e1c \u0111\u1ecbnh t\u1eeb n\u1ed3ng \u0111\u1ed9 PSA th\u1ea5p nh\u1ea5t t\u1eeb khi d\u00f9ng Dutasteride th\u00ec c\u00f3 th\u1ec3 \u0111\u00f3 l\u00e0 d\u1ea5u hi\u1ec7u c\u1ee7a ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t (\u0111\u1eb7c bi\u1ec7t ung th\u01b0 m\u1ee9c \u0111\u1ed9 cao) ho\u1eb7c kh\u00f4ng bi\u1ebfn ch\u1ee9ng. \u0110\u1ed1i v\u1edbi nam gi\u1edbi kh\u00f4ng d\u00f9ng ch\u1ea5t \u1ee9c ch\u1ebf 5-alpha-reductase, n\u00ean \u0111\u00e1nh gi\u00e1 c\u1ea9n th\u1eadn ngay c\u1ea3 khi c\u00e1c gi\u00e1 tr\u1ecb n\u00e0y v\u1eabn n\u1eb1m trong kho\u1ea3ng b\u00ecnh th\u01b0\u1eddng.<\/li>\n<li>Vi\u1ec7c s\u1eed d\u1ee5ng d\u1ee5ng c\u1ee5 th\u1eed PSA \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi Dutasteride.<\/li>\n<li>Trong v\u00f2ng 6 th\u00e1ng khi ng\u01b0ng \u0111i\u1ec1u tr\u1ecb, c\u00e1c gi\u00e1 tr\u1ecb PSA to\u00e0n ph\u1ea7n trong huy\u1ebft thanh s\u1ebd tr\u1edf v\u1ec1 \u0111\u01b0\u1eddng c\u01a1 b\u1ea3n. T\u1ec9 l\u1ec7 gi\u1eefa PSA t\u1ef1 do v\u00e0 to\u00e0n ph\u1ea7n v\u1eabn kh\u00f4ng \u0111\u1ed5i. N\u1ebfu s\u1eed d\u1ee5ng % PSA t\u1ef1 do \u0111\u1ec3 ph\u00e1t hi\u1ec7n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t \u1edf nam gi\u1edbi tr\u1ea3i qua \u0111i\u1ec1u tr\u1ecb Dutasteride th\u00ec kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh gi\u00e1 tr\u1ecb PSA.<\/li>\n<\/ul>\n<p>Ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t v\u00e0 kh\u1ed1i u \u1edf m\u1ee9c \u0111\u1ed9 cao:<\/p>\n<p>V\u1eabn ch\u01b0a r\u00f5 m\u1ed1i quan h\u1ec7 gi\u1eefa Dutasteride v\u00e0 ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t m\u1ee9c \u0111\u1ed9 cao. V\u00ec v\u1eady, khi d\u00f9ng Dutasteride c\u1ea7n \u0111\u00e1nh gi\u00e1 th\u01b0\u1eddng xuy\u00ean nguy c\u01a1 ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t, k\u1ec3 c\u1ea3 ki\u1ec3m tra PSA.<\/p>\n<p>Vi\u00ean thu\u1ed1c b\u1ecb r\u00f2 r\u1ec9:<br \/>\nPh\u1ee5 n\u1eef, tr\u1ebb em, thanh thi\u1ebfu ni\u00ean tr\u00e1nh ti\u1ebfp x\u00fac v\u1edbi vi\u00ean nang b\u1ecb r\u00f2 r\u1ec9 v\u00ec Dutasteride h\u1ea5p thu qua da. N\u1ebfu l\u1ee1 ti\u1ebfp x\u00fac th\u00ec c\u1ea7n r\u1eeda v\u00f9ng ti\u1ebfp x\u00fac ngay b\u1eb1ng x\u00e0 ph\u00f2ng v\u00e0 n\u01b0\u1edbc.<\/p>\n<p>Suy gan: b\u1ec7nh nh\u00e2n suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Dutasteride.<\/p>\n<p>Ung th\u01b0 v\u00fa:<br \/>\nTrong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 trong giai \u0111o\u1ea1n sau khi d\u00f9ng thu\u1ed1c, \u0111\u00e3 xu\u1ea5t hi\u1ec7n ung th\u01b0 v\u00fa \u1edf nam gi\u1edbi d\u00f9ng Dutasteride. N\u1ebfu th\u1ea5y b\u1ea5t k\u1ef3 thay \u0111\u1ed5i n\u00e0o \u1edf m\u00f4 v\u00fa nh\u01b0 c\u00f3 b\u01b0\u1edbu ho\u1eb7c ti\u1ebft d\u1ecbch \u1edf \u0111\u1ea7u n\u00fam v\u00fa th\u00ec ph\u1ea3i b\u00e1o ngay v\u1edbi b\u00e1c s\u0129. Hi\u1ec7n t\u1ea1i, v\u1eabn ch\u01b0a r\u00f5 li\u00ean quan gi\u1eefa s\u1ef1 xu\u1ea5t hi\u1ec7n ung th\u01b0 v\u00fa \u1edf nam gi\u1edbi v\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng l\u00e2u d\u00e0i Dutasteride.<\/p>\n<p>Thu\u1ed1c ch\u1ee9a lecithin c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u1ea7u \u0111\u1eadu n\u00e0nh. V\u00ec v\u1eady, kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y n\u1ebfu d\u1ecb \u1ee9ng v\u1edbi \u0111\u1eadu ph\u1ed9ng ho\u1eb7c \u0111\u1eadu n\u00e0nh.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>\u0110\u01a1n tr\u1ecb li\u1ec7u Dutasteride<\/li>\n<\/ul>\n<p>Th\u1eed nghi\u1ec7m trong 2 n\u0103m v\u1edbi 2167 b\u1ec7nh nh\u00e2n d\u00f9ng Dutasteride \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c giai \u0111o\u1ea1n 3, c\u00f3 kho\u1ea3ng 19% trong s\u1ed1 \u0111\u00f3 \u0111\u00e3 xu\u1ea5t hi\u1ec7n c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n trong su\u1ed1t n\u0103m \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<br \/>\nC\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u00e3 xu\u1ea5t hi\u1ec7n ch\u1ee7 y\u1ebfu tr\u00ean h\u1ec7 th\u1ed1ng sinh s\u1ea3n v\u00e0 ti\u1ebft s\u1eefa g\u1ed3m: b\u1ec7nh li\u1ec7t d\u01b0\u01a1ng, sinh d\u1ee5c bi\u1ebfn \u0111\u1ed5i (gi\u1ea3m), r\u1ed1i lo\u1ea1n ph\u00f3ng tinh d\u1ecbch, r\u1ed1i lo\u1ea1n ti\u1ebft s\u1eefa,&#8230;<\/p>\n<ul>\n<li>Dutasteride k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf alpha tamsulosin<\/li>\n<\/ul>\n<p>Nghi\u00ean c\u1ee9u cho th\u1ea5y khi ph\u1ed1i h\u1ee3p Dutasteride 0,5 mg m\u1ed9t l\u1ea7n\/ ng\u00e0y v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf alpha tamsulosin 0,4 mg m\u1ed9t l\u1ea7n \/ ng\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/p>\n<table style=\"border-collapse: collapse;width: 100%;height: 126px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td style=\"width: 44.5774%;height: 21px;text-align: center\">H\u1ec7 c\u01a1 quan<\/td>\n<td style=\"width: 55.4226%;height: 21px;text-align: center\">T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 44.5774%;height: 21px\">H\u1ec7 th\u1ea7n kinh<\/td>\n<td style=\"width: 55.4226%;height: 21px\">Ch\u00f3ng m\u1eb7t<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 44.5774%;height: 21px\">Tim m\u1ea1ch<\/td>\n<td style=\"width: 55.4226%;height: 21px\">Suy tim<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 44.5774%;height: 21px\" rowspan=\"3\">H\u1ec7 th\u1ed1ng sinh s\u1ea3n v\u00e0 ti\u1ebft s\u1eefa, c\u00e1c r\u1ed1i lo\u1ea1n tinh th\u1ea7n<\/td>\n<td style=\"width: 55.4226%;height: 21px\">T\u00ecnh d\u1ee5c thay \u0111\u1ed5i<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 55.4226%;height: 21px\">R\u1ed1i lo\u1ea1n ti\u1ebft s\u1eefa<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"width: 55.4226%;height: 21px\">R\u1ed1i lo\u1ea1n ph\u00f3ng tinh<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Nghi\u00ean c\u1ee9u kh\u00e1c cho th\u1ea5y, \u1edf nh\u00f3m d\u00f9ng Dutasteride, t\u1ef7 l\u1ec7 ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t Gleason 8-10 cao h\u01a1n so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c. Tuy nhi\u00ean, ch\u01b0a thi\u1ebft l\u1eadp t\u00e1c d\u1ee5ng c\u1ee7a Dutasteride \u0111\u1ebfn gi\u1ea3m k\u00edch th\u01b0\u1edbc tuy\u1ebfn ti\u1ec1n li\u1ec7t, c\u00e1c y\u1ebfu t\u1ed1 li\u00ean quan \u0111\u1ebfn nghi\u00ean c\u1ee9u v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u.<br \/>\nUng th\u01b0 v\u00fa \u1edf nam gi\u1edbi \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 sau khi s\u1eed d\u1ee5ng thu\u1ed1c.<br \/>\nTheo d\u00f5i t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n l\u00e0 \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng. Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u0129 n\u1ebfu g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>T\u01b0\u01a1ng t\u00e1c c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c \u0111\u1ed1i v\u1edbi Dutasteride:<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 46.6507%;text-align: center\">T\u01b0\u01a1ng t\u00e1c<\/td>\n<td style=\"width: 53.3493%;text-align: center\">T\u00e1c \u0111\u1ed9ng<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 46.6507%\">Ph\u1ed1i h\u1ee3p v\u1edbi CYP3A4 v\u00e0 \/ho\u1eb7c ch\u1ea5t \u1ee9c ch\u1ebf glycoprotein P.<\/td>\n<td style=\"width: 53.3493%\">Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u ch\u00ednh th\u1ee9c n\u00e0o.<br \/>\nTuy nhi\u00ean, trong m\u1ed9t nghi\u00ean c\u1ee9u \u1edf m\u1ed9t s\u1ed1 nh\u1ecf b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi v\u1edbi verapamil ho\u1eb7c diltiazem th\u00ec n\u1ed3ng \u0111\u1ed9 Dutasteride huy\u1ebft thanh trung b\u00ecnh cao h\u01a1n 1,6 \u0111\u1ebfn 1,8 l\u1ea7n.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 46.6507%\">K\u1ebft h\u1ee3p l\u00e2u d\u00e0i Dutasteride v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh enzym CYP3A4 ( ritonavir, indinavir, nefazodone, itraconazol, ketoconazol u\u1ed1ng).<\/td>\n<td style=\"width: 53.3493%\">C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Dutasteride trong huy\u1ebft thanh. N\u1eeda \u0111\u1eddi b\u00e1n th\u1ea3i d\u00e0i c\u00f3 th\u1ec3 k\u00e9o d\u00e0i h\u01a1n v\u00e0 c\u00f3 th\u1ec3 ph\u1ea3i m\u1ea5t h\u01a1n 6 th\u00e1ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi m\u1edbi \u0111\u1ea1t \u0111\u01b0\u1ee3c tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li>T\u01b0\u01a1ng t\u00e1c c\u1ee7a Dutasteride \u0111\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 23.3652%;text-align: center\">T\u01b0\u01a1ng t\u00e1c<\/td>\n<td style=\"width: 76.6348%;text-align: center\">T\u00e1c \u0111\u1ed9ng<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 23.3652%\">Warfarin ho\u1eb7c digoxin<\/td>\n<td style=\"width: 76.6348%\">Dutasteride kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c thu\u1ed1c n\u00e0y. Ch\u1ee9ng t\u1ecf Dutasteride kh\u00f4ng \u1ee9c ch\u1ebf\/c\u1ea3m \u1ee9ng CYP2C9 ho\u1eb7c ch\u1ea5t t\u1ea3i P-glycoprotein. Dutasteride c\u0169ng kh\u00f4ng \u1ee9c ch\u1ebf c\u00e1c enzym CYP1A2, CYP2D6, CYP2C9, CYP2C19 ho\u1eb7c CYP3A4 tr\u00ean m\u00f4 h\u00ecnh in vitro.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 23.3652%\">Tamsulosin ho\u1eb7c terazosin<\/td>\n<td style=\"width: 76.6348%\">Trong m\u1ed9t nghi\u00ean c\u1ee9u nh\u1ecf ch\u1ec9 ra r\u1eb1ng Dutasteride kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c thu\u1ed1c n\u00e0y v\u00e0 c\u0169ng kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c x\u1ea3y ra.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng d\u00f9ng Dutasvitae cho ph\u1ee5 n\u1eef.<\/p>\n<p>Kh\u1ea3 n\u0103ng sinh s\u1ea3n: \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a Dutasvitae \u0111\u1ebfn tinh tr\u00f9ng \u1edf nh\u1eefng ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng kh\u1ecfe m\u1ea1nh (gi\u1ea3m s\u1ed1 tinh tr\u00f9ng, th\u1ec3 t\u00edch tinh d\u1ecbch v\u00e0 v\u1eadn \u0111\u1ed9ng c\u1ee7a tinh tr\u00f9ng). V\u00ec v\u1eady, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng sinh s\u1ea3n \u1edf nam gi\u1edbi.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai: ph\u1ee5 n\u1eef c\u00f3 ph\u00f4i thai mang gi\u1edbi t\u00ednh nam d\u00f9ng thu\u1ed1c c\u00f3 th\u1ec3 s\u1ebd \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n b\u1ed9 ph\u1eadn sinh d\u1ee5c ngo\u00e0i c\u1ee7a ph\u00f4i thai v\u00ec Dutasteride \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n \u0111\u1ed5i testosterone th\u00e0nh dihydrotestosterone. Trong tinh d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n d\u00f9ng Dutasteride 0,5 mg\/ng\u00e0y c\u00f3 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf Dutasteride \u0111\u01b0\u1ee3c ph\u1ee5c h\u1ed3i. Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c ph\u00f4i thai gi\u1edbi t\u00ednh nam c\u00f3 b\u1ecb \u1ea3nh h\u01b0\u1edfng x\u1ea5u n\u1ebfu ng\u01b0\u1eddi m\u1eb9 mang thai ph\u01a1i nhi\u1ec5m v\u1edbi tinh d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb Dutasteride. V\u00ec v\u1eady, tr\u00e1nh ti\u1ebfp x\u00fac v\u1edbi tinh d\u1ecbch trong quan h\u1ec7 b\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng bao cao su.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef cho con b\u00fa: Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c Dutasteride c\u00f3 \u0111i v\u00e0o \u0111\u01b0\u1ee3c s\u1eefa m\u1eb9 hay kh\u00f4ng.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Qu\u00e1 li\u1ec1u<br \/>\nNghi\u00ean c\u1ee9u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Dutasteride 40mg\/ng\u00e0y, trong 7 ng\u00e0y m\u00e0 kh\u00f4ng th\u1ea5y hi\u1ec7n t\u01b0\u1ee3ng qu\u00e1 li\u1ec1u x\u1ea3y ra. Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, li\u1ec1u 5 mg\/ ng\u00e0y, trong 6 th\u00e1ng \u0111\u00e3 \u0111\u01b0\u1ee3c d\u00f9ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng m\u00e0 kh\u00f4ng c\u00f3 c\u00e1c t\u00e1c d\u1ee5ng ngo\u00e0i \u00fd mu\u1ed1n.<\/li>\n<li>C\u00e1ch x\u1eed tr\u00ed<br \/>\nTrong tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra qu\u00e1 li\u1ec1u, c\u1ea7n \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 d\u00f9ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 ph\u00f9 h\u1ee3p.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Dutasvitae 0.5mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Dutasvitae 0.5mg<\/strong> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/avodart\/\">Avodart<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty GlaxoSmithKline Pharmaceuticals SA \u2013 BA LAN ch\u1ee9a Dutasteride h\u00e0m l\u01b0\u1ee3ng 0.5mg. Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t, t\u0103ng s\u1ef1 v\u1eadn chuy\u1ec3n, l\u01b0u th\u00f4ng n\u01b0\u1edbc ti\u1ec3u, gi\u1ea3m t\u00ecnh tr\u1ea1ng b\u00ed ti\u1ec3u. B\u1ea1n c\u00f3 th\u1ec3 d\u00f9ng \u0111\u01b0\u1ee3c trong 1 th\u00e1ng v\u1edbi li\u1ec1u d\u00f9ng 1 vi\u00ean\/ ng\u00e0y v\u00e0 c\u00f3 gi\u00e1 kho\u1ea3ng 590.000 \u0111\u1ed3ng\/ 1 h\u1ed9p 3 v\u1ec9 x 30 vi\u00ean.<\/p>\n<h2>T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c?<\/h2>\n<table style=\"border-collapse: collapse;width: 100%\">\n<tbody>\n<tr>\n<td style=\"width: 60.5263%;text-align: center\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 39.4737%;text-align: center\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 60.5263%\">Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng, d\u00f9ng Dutasteride 0,5 mg\/ng\u00e0y l\u00e0m gi\u1ea3m nguy c\u01a1 b\u00ed ti\u1ec3u c\u1ea5p t\u00ednh v\u00e0 nhu c\u1ea7u can thi\u1ec7p ph\u1eabu thu\u1eadt li\u00ean quan \u0111\u1ebfn t\u0103ng s\u1ea3n tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh, c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn t\u0103ng s\u1ea3n tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh.<\/td>\n<td style=\"width: 39.4737%\">S\u1eed d\u1ee5ng Dutasteride c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0: suy tim, thay \u0111\u1ed5i t\u00ecnh d\u1ee5c, ung th\u01b0 v\u00fa \u1edf \u0111\u00e0n \u00f4ng,&#8230;<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 60.5263%\">D\u00f9ng ph\u1ed1i h\u1ee3p Dutasteride 0,5 mg\u00a0 v\u00e0 tamsulosin 0,2 mg cho k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng t\u1ed1t h\u01a1n so v\u1edbi \u0111\u01a1n tr\u1ecb li\u1ec7u tamsulosin 0,2 mg. Bi\u1ec7n ph\u00e1p ph\u1ed1i h\u1ee3p n\u00e0y hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n cho nam gi\u1edbi m\u1eafc ph\u00ec tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0nh t\u00ednh t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng.<\/td>\n<td style=\"width: 39.4737%\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 60.5263%\">Li\u1ec1u d\u00f9ng \u0111\u01a1n gi\u1ea3n, d\u1ec5 nh\u1edb, d\u1ec5 s\u1eed d\u1ee5ng.<\/td>\n<td style=\"width: 39.4737%\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u00e1c gi\u1ea3 Hannah C Evans, Karen L Goa (Th\u1eddi gian ph\u00e1t h\u00e0nh n\u0103m 2003). <em>Dutasteride<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 16 th\u00e1ng 09 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30198102\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/14565784\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3\u00a0 Nazneen Haque v\u00e0 c\u1ed9ng s\u1ef1. (Th\u1eddi gian ph\u00e1t h\u00e0nh ng\u00e0y 09 th\u00e1ng 09 n\u0103m 2018). <em>Superiority of dutasteride 0.5 mg and tamsulosin 0.2 mg for the treatment of moderate-to-severe benign prostatic hyperplasia in Asian men<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 16 th\u00e1ng 09 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30198102\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30198102\/<\/a><\/li>\n<li>T\u00e1c gi\u1ea3\u00a0 Xavier Rabaseda. (Th\u1eddi gian ph\u00e1t h\u00e0nh th\u00e1ng 08 n\u0103m 2004). <em>Dutasteride: a potent dual inhibitor of 5-alpha-reductase for benign prostatic hyperplasia<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 16 th\u00e1ng 09 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15510237\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15510237\/<\/a><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n pdf <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2023\/09\/Dutasvitae-05mg-vnras.pdf\">T\u1ea0I \u0110\u00c2Y<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Dutasvitae 0.5mg c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ph\u00ec \u0111\u1ea1i ti\u1ec1n li\u1ec7t tuy\u1ebfn<\/p>\n","protected":false},"author":490,"featured_media":42655,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-42653","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/42653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=42653"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/42655"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=42653"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=42653"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=42653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}