{"id":40360,"date":"2023-08-31T06:44:30","date_gmt":"2023-08-30T23:44:30","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=40360"},"modified":"2025-07-24T14:03:54","modified_gmt":"2025-07-24T07:03:54","slug":"thuoc-egudin-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-egudin-5\/","title":{"rendered":"Egudin 5"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Egudin 5<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Me Di Sun, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 QL\u0110B-681-18.<\/strong><\/p>\n

Egudin 5 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Th\u00e0nh ph\u1ea7n<\/h3>\n
Thu\u1ed1c Egudin 5 c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:
\nHo\u1ea1t ch\u1ea5t:
\nSolifenacin Succinate:\u00a0 5mg
\nT\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean n\u00e9n.
\nD\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n
Tr\u00ecnh b\u00e0y<\/h2>\n
S\u0110K: QL\u0110B-681-18
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean.
\nXu\u1ea5t x\u1ee9:\u00a0 Vi\u1ec7t Nam<\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Egudin 5<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
Th\u1ee5 th\u1ec3 Muscarinic l\u00e0 m\u1ed9t th\u1ee5 th\u1ec3 \u0111\u1ed1i kh\u00e1ng c\u1ea1nh tranh v\u1edbi Solifenacin, \u0111\u00f3ng vai tr\u00f2 trung gian r\u1ea5t quan tr\u1ecdng trong h\u1ec7 Cholinergic (h\u1ec7 th\u1ea7n kinh \u0111\u1ed1i giao c\u1ea3m) g\u1ed3m l\u00e0m co th\u1eaft c\u01a1 tr\u01a1n b\u00e0ng quang v\u00e0 k\u00edch th\u00edch ti\u1ebft n\u01b0\u1edbc b\u1ecdt.<\/p>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
H\u1ea5p thu:
\nN\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (th\u1eed nghi\u1ec7m \u0111\u1ed1i t\u01b0\u1ee3ng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh) \u0111\u1ea1t \u0111\u01b0\u1ee3c trong kho\u1ea3ng 3 \u2013 8 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c. \u1ede tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t t\u1eeb 32,3 \u2013 62,9 ng\/ml, t\u01b0\u01a1ng \u1ee9ng li\u1ec1u 5 v\u00e0 10mg. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i x\u1ea5p x\u1ec9 90%. N\u1ed3ng \u0111\u1ed9\u00a0 t\u1ef7 l\u1ec7 chu\u1ea9n v\u1edbi li\u1ec1u d\u00f9ng trong huy\u1ebft t\u01b0\u01a1ng. C\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c trong b\u1eefa \u0103n do th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a thu\u1ed1c.
\nPh\u00e2n b\u1ed1:
\nKho\u1ea3ng 98% thu\u1ed1c g\u1eafn k\u1ebft v\u1edbi huy\u1ebft t\u01b0\u01a1ng, g\u1eafn ch\u1ee7 y\u1ebfu v\u1edbi \u03b11-acid Glycoprotein. Thu\u1ed1c ph\u00e2n b\u1ed1 cao \u0111\u1ebfn c\u00e1c m\u00f4 kh\u00f4ng thu\u1ed9c h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh, \u1ed5n \u0111\u1ecbnh 600L.
\nChuy\u1ec3n h\u00f3a:
\nChuy\u1ec3n h\u00f3a \u1edf gan, th\u1ea3i tr\u1eeb ch\u00ednh qua CYP3A4. V\u1eabn c\u00f3 th\u1ec3 th\u1ea3i tr\u1eeb qua con \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t thay th\u1ebf. Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a ch\u00ednh nh\u1edd s\u1ef1 oxy h\u00f3a v\u1ecb tr\u00ed N c\u1ee7a v\u00f2ng Nuinuclidin v\u00e0 Hydroxyl h\u00f3a v\u1ecb tr\u00ed 4R c\u1ee7a v\u00f2ng Tetrahydroisoquinolin. 4R Hydroxy Solifenacin l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh, N\u2013Glucuronid, N\u2013Oxid v\u00e0 4R\u2013Hydroxy\u2013N\u2013Oxid c\u1ee7a Solifenacin l\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh sau khi u\u1ed1ng \u0111\u00e3 t\u00ecm th\u1ea5y trong huy\u1ebft t\u01b0\u01a1ng.
\nTh\u1ea3i tr\u1eeb:
\n69,2% li\u1ec1u \u0111\u01b0\u1ee3c thu l\u1ea1i trong n\u01b0\u1edbc ti\u1ec3u, 22,5% \u1edf ph\u00e2n qua h\u01a1n 26 ng\u00e0y sau khi d\u00f9ng li\u1ec1u 10mg tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh.
\nThu h\u1ed3i \u0111\u01b0\u1ee3c kho\u1ea3ng 15% Solifenacin kh\u00f4ng chuy\u1ec3n h\u00f3a trong n\u01b0\u1edbc ti\u1ec3u.
\nTrong n\u01b0\u1edbc ti\u1ec3u c\u00f3 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh: N\u2013Oxid c\u1ee7a Solifenacin, 4R-Hydroxy Solifenacin v\u00e0 4R\u2013Hydroxy\u2013N\u2013Oxid c\u1ee7a Solifenacin; trong ph\u00e2n l\u00e0 4R-Hydroxy Solifenacin.
\nTh\u1eddi gian b\u00e1n th\u1ea3i khi d\u00f9ng th\u1eddi gian d\u00e0i l\u00e0 trong 45 – 68 gi\u1edd.<\/p>\n\n\n\n\n\n\n\n\n\n
\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/td>\n D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/td>\n<\/tr>\n
Tr\u1ebb em<\/td>\n Ch\u01b0a \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh.<\/td>\n<\/tr>\n
Ng\u01b0\u1eddi cao tu\u1ed5i<\/td>\n C\u00e1c th\u00f4ng s\u1ed1 Cmax, AUC v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Solifenacin tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng t\u1eeb 65 – 80 tu\u1ed5i ch\u1ec9 ra cao h\u01a1n kho\u1ea3ng 20 – 25% so v\u1edbi \u0111\u1ed1i t\u01b0\u1ee3ng t\u1eeb 18 – 55 tu\u1ed5i.<\/td>\n<\/tr>\n
Gi\u1edbi t\u00ednh<\/td>\n Kh\u00f4ng b\u1ecb b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3<\/td>\n<\/tr>\n
Ch\u1ee7ng t\u1ed9c<\/td>\n Kh\u00f4ng \u0111\u1ee7 k\u1ebft lu\u1eadn<\/td>\n<\/tr>\n
\u0110\u1ed1i t\u01b0\u1ee3ng suy th\u1eadn<\/td>\n Auc t\u0103ng g\u1ea5p 2.5 l\u1ea7n.
\nB\u1ec7nh suy th\u1eadn n\u1eb7ng, th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng g\u1ea5p 1.6 l\u1ea7n.<\/td>\n<\/tr>\n
\u0110\u1ed1i t\u01b0\u1ee3ng suy gan<\/td>\n Auc t\u0103ng 35%
\n\u0110\u1ed1i t\u01b0\u1ee3ng suy gan trung b\u00ecnh: Th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng g\u1ea5p \u0111\u00f4i.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Ch\u00fa th\u00edch:
\nCmax: N\u1ed3ng \u0111\u1ed9 thu\u1ed1c t\u1ed1i \u0111a
\nAUC: Di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong, bi\u1ec3u di\u1ec5n s\u1ef1 bi\u1ebfn thi\u00ean c\u1ee7a n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u theo th\u1eddi gian<\/p>\n
Thu\u1ed1c Egudin 5 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
Solifenacin <\/strong>\u00a0l\u00e0 lo\u1ea1i thu\u1ed1c thu\u1ed9c nh\u00f3m ti\u1ebft ni\u1ec7u -sinh d\u1ee5c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng ti\u1ec3u ti\u1ec3u s\u00f3n, ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7, ti\u1ec3u nhi\u1ec1u l\u1ea7n, ti\u1ec3u g\u1ea5p \u1edf b\u1ec7nh nh\u00e2n b\u1ecb h\u1ed9i ch\u1ee9ng b\u00e0ng quang t\u0103ng ho\u1ea1t \u0111\u1ed9ng.<\/p>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c\u00a0 Egudin 5<\/h2>\n\n\n\n\n
Ng\u01b0\u1eddi l\u1edbn, ng\u01b0\u1eddi cao tu\u1ed5i<\/td>\n Tr\u1ebb em<\/td>\n B\u1ec7nh nh\u00e2n suy th\u1eadn<\/td>\n B\u1ec7nh nh\u00e2n suy gan<\/td>\n Ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4<\/td>\n<\/tr>\n
Khuy\u1ebfn c\u00e1o: 1 vi\u00ean\/1 l\u1ea7n\/1 ng\u00e0y.
\nN\u1ebfu dung n\u1ea1p t\u1ed1t \u1edf li\u1ec1u 5mg, c\u00e2n nh\u1eafc t\u0103ng li\u1ec1u 2 vi\u00ean\/1 l\u1ea7n\/ 1 ng\u00e0y.<\/td>\n S\u1ef1 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5, do v\u1eady kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng tr\u00ean nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y<\/td>\n Suy th\u1eadn nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n
Suy th\u1eadn n\u1eb7ng: M\u1ed7i ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c qu\u00e1 1 vi\u00ean.<\/td>\n
Suy gan nh\u1eb9: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.
\nSuy gan trung b\u00ecnh: M\u1ed7i ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c qu\u00e1 1 vi\u00ean thu\u1ed1c.<\/td>\n M\u1ed7i ng\u00e0y kh\u00f4ng qu\u00e1 1 vi\u00ean thu\u1ed1c.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Egudin 5 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
Kh\u00f4ng s\u1eed d\u1ee5ng d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p: B\u1ec7nh nh\u00e2n b\u1ecb: B\u00ed ti\u1ec3u, \u1ee9 d\u1ecbch d\u1ea1 d\u00e0y, Glaucoma g\u00f3c h\u1eb9p kh\u00f4ng ki\u1ec3m so\u00e1t.
\nSuy gan n\u1eb7ng (Child-Pugh C).
\nQu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Egudin 5<\/h2>\n
Th\u1eadn tr\u1ecdng<\/h3>\n\n\n\n\n\n\n\n\n\n\n\n
Bi\u1ec3u hi\u1ec7n<\/td>\n X\u1eed tr\u00ed<\/td>\n<\/tr>\n
Ph\u00f9 m\u1ea1ch \u1edf m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i v\u00e0\/ho\u1eb7c thanh qu\u1ea3n<\/td>\n Ng\u01b0ng thu\u1ed1c, s\u1eed s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p ph\u00f9 h\u1ee3p h\u1ee3p \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u0111\u01b0\u1eddng \u0111\u01b0\u1eddng th\u1edf cho ng\u01b0\u1eddi b\u1ec7nh<\/td>\n<\/tr>\n
Qu\u00e1 m\u1eabn \u0111\u00e3 bi\u1ebft ho\u1eb7c nghi ng\u1edd v\u1edbi Solifenacin succinat<\/td>\n Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c.<\/td>\n<\/tr>\n
Nh\u1ee9c \u0111\u1ea7u, l\u00fa l\u1eabn, \u1ea3o gi\u00e1c v\u00e0 bu\u1ed3n ng\u1ee7<\/td>\n C\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i. Xem x\u00e9t gi\u1ea3m ho\u1eb7c ng\u1eebng thu\u1ed1c.<\/td>\n<\/tr>\n
\u00a0B\u00ed ti\u1ec3u<\/td>\n S\u1eed d\u1ee5ng thu\u1ed1c th\u1eadn tr\u1ecdng tr\u00ean c\u00e1c nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/td>\n<\/tr>\n
Gi\u1ea3m nhu \u0111\u1ed9ng ru\u1ed9t<\/td>\n<\/tr>\n
\u00a0\u0110ang \u0111i\u1ec1u tr\u1ecb Glaucoma g\u00f3c h\u1eb9p<\/td>\n<\/tr>\n
Suy gan, suy th\u1eadn<\/td>\n<\/tr>\n
Ng\u01b0\u1eddi b\u1ec7nh b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed b\u1ecb k\u00e9o d\u00e0i kho\u1ea3ng QT, \u0111ang d\u00f9ng thu\u1ed1c l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n
R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/h4>\n
Kh\u00f4 mi\u1ec7ng<\/p>\n
Th\u01b0\u1eddng g\u1eb7p<\/h4>\n
Nh\u00ecn m\u1edd, t\u00e1o b\u00f3n, kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n,ch\u1ee9ng kh\u00f3 ti\u00eau.<\/p>\n
\u00cdt g\u1eb7p<\/h4>\n
Nhi\u1ec5m tr\u00f9ng: \u0110\u01b0\u1eddng ti\u1ec3u b\u1ecb nhi\u1ec5m tr\u00f9ng, vi\u00eam b\u00e0ng quang.
\nH\u1ec7 th\u1ea7n kinh: Bu\u1ed3n ng\u1ee7, r\u1ed1i lo\u1ea1n vj gi\u00e1c.
\nM\u1eaft: M\u1eaft b\u1ecb kh\u00f4.
\nH\u00f4 h\u1ea5p: Kh\u00f4 m\u0169i
\nTi\u00eau h\u00f3a: Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y, kh\u00f4 h\u1ecdng.
\nDa: Kh\u00f4 da
\nTi\u1ebft ni\u1ec7u: Kh\u00f3 ti\u1ec3u
\nTo\u00e0n th\u00e2n: M\u1ec7t m\u1ecfi, ph\u00f9 ngo\u1ea1i bi\u00ean.<\/p>\n
Hi\u1ebfm g\u1eb7p<\/h4>\n
Th\u1ea7n kinh: Ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.
\nTi\u00eau h\u00f3a: T\u1eafc ngh\u1ebdn, ph\u00e2n r\u1eafn, n\u00f4n.
\nDa: Ng\u1ee9a, n\u1ed5i ban.
\nTh\u1eadn, ti\u1ebft ni\u1ec7u: B\u00ed ti\u1ec3u<\/p>\n
R\u1ea5t hi\u1ebfm g\u1eb7p<\/h4>\n
\u1ea2o gi\u00e1c, r\u1ed1i lo\u1ea1n tinh th\u1ea7n, m\u00e0y \u0111ay, ph\u00f9 m\u1ea1ch.<\/p>\n
Ch\u01b0a r\u00f5 t\u1ea7n su\u1ea5t<\/h4>\n
H\u1ec7 mi\u1ec5n d\u1ecbch: B\u1ecb r\u1ed1i lo\u1ea1n.
\nChuy\u1ec3n h\u00f3a, dinh d\u01b0\u1ee1ng: T\u0103ng Kali m\u00e1u, ch\u00e1n \u0103n.
\nT\u00e2m th\u1ea7n: M\u00ea s\u1ea3ng
\nR\u1ed1i lo\u1ea1n m\u1eaft: Glaucoma
\nTim: Xo\u1eafn \u0111\u1ec9nh, rung nh\u0129, k\u00e9o d\u00e0i kho\u1ea3ng QT, nh\u1ecbp nhanh, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c.
\nTi\u00eau h\u00f3a: Li\u1ec7t ru\u1ed9t, B\u1ee5ng kh\u00f3 ch\u1ecbu.
\nGan m\u1eadt: Ch\u1ee9c n\u0103ng b\u1ecb r\u1ed1i lo\u1ea1n,x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng.
\nDa: Vi\u00eam da, tr\u00f3c v\u1ea3y.
\nC\u01a1: Nh\u01b0\u1ee3c c\u01a1.
\nTh\u1eadn: Suy th\u1eadn.<\/p>\n
T\u01b0\u01a1ng t\u00e1c<\/h3>\n\n\n\n\n\n\n\n\n\n
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Thu\u1ed1c<\/td>\n \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0T\u01b0\u01a1ng t\u00e1c<\/td>\n<\/tr>\n
Thu\u1ed1c chuy\u1ec3n h\u00f3a qua cytochrom P450<\/td>\n Thu\u1ed1c kh\u00f4ng l\u00e0m \u1ee9c ch\u1ebf CYP1A1\/2, 2C9, 2C19, 2D6, ho\u1eb7c 3A4 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb microsom gan ng\u01b0\u1eddi \u1edf n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb.<\/td>\n<\/tr>\n
C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4<\/td>\n D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c b\u1ecb thay \u0111\u1ed5i.<\/td>\n<\/tr>\n
Ketoconazol<\/td>\n D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u1ee7a thu\u1ed1c b\u1ecb thay \u0111\u1ed5i<\/td>\n<\/tr>\n
Warfarin<\/td>\n D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a R-warfarin ho\u1eb7c S-warfarin \u00edt b\u1ecb \u1ea3nh h\u01b0\u1edfng.<\/td>\n<\/tr>\n
Digoxin<\/td>\n \u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng, kh\u1ecfe m\u1ea1nh th\u00ec d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Digoxin kh\u00f4ng b\u1ecb thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3<\/td>\n<\/tr>\n
Thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng<\/td>\n N\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng c\u1ee7a thu\u1ed1c tr\u00e1nh thai k\u1ebft h\u1ee3p kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n
Tr\u1eeb khi l\u1ee3i \u00edch l\u1edbn h\u01a1n nguy c\u01a1, n\u1ebfu kh\u00f4ng kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng d\u1ee5ng thu\u1ed1c \u1edf nh\u00f3m ph\u1ee5 n\u1eef mang thai do ch\u01b0a c\u00f3 c\u00e1c ch\u1ee9ng c\u1ee9 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.
\nThu\u1ed1c c\u00f3 v\u00e0o \u0111\u01b0\u1ee3c s\u1eefa m\u1eb9 hay kh\u00f4ng l\u00e0 ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u. C\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa vi\u1ec7c \u0111i\u1ec1u tr\u1ecb cho m\u1eb9 v\u00e0 vi\u1ec7c cho con b\u00fa.<\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n\n\n\n\n
<\/td>\n \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Bi\u1ec3u hi\u1ec7n<\/td>\n \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 X\u1eed tr\u00ed<\/td>\n<\/tr>\n
Qu\u00e1 li\u1ec1u<\/td>\n Gi\u00e3n \u0111\u1ed3ng t\u1eed, m\u1edd m\u1eaft, run v\u00e0 kh\u00f4 da.<\/td>\n R\u1eeda d\u1ea1 d\u00e0y
\nS\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p h\u1ed7 tr\u1ee3 th\u00edch h\u1ee3p.
\n\u0110\u1ec1 xu\u1ea5t theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Thu\u1ed1c Egudin 5 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n
Thu\u1ed1c Egudin 5\u00a0 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.
\nK\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:
\nAlsiful S.R<\/a> do C\u00f4ng ty C\u1ed5 ph\u1ea7n Sao Th\u00e1i D\u01b0\u01a1ng s\u1ea3n xu\u1ea5t, \u0111\u00e2y l\u00e0 m\u1ed9t c\u00f4ng ty c\u00f3 tu\u1ed5i \u0111\u1eddi l\u00e2u n\u0103m, uy t\u00edn \u1edf Vi\u1ec7t Nam v\u1edbi gi\u00e1 kho\u1ea3ng 340.000\/1 h\u1ed9p v\u00e0 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n ph\u00f3ng th\u00edch ch\u1eadm gi\u00fap cho hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ea1t k\u1ebft qu\u1ea3 t\u1ed1t nh\u1ea5t.
\n Cefalexin capsules BP<\/a> do c\u00f4ng ty BRAWN LABORATORIES LIMITED, \u1ea4n \u0110\u1ed9 s\u1ea3n xu\u1ea5t theo ti\u00eau chu\u1ea9n hi\u1ec7n \u0111\u1ea1i. Tuy nhi\u00ean gi\u00e1 th\u00e0nh c\u1ee7a s\u1ea3n ph\u1ea9m n\u00e0y l\u1ea1i h\u01a1i cao: 1.200.000 cho m\u1ed9t h\u1ed9p. M\u1ee9c gi\u00e1 n\u00e0y kh\u00e1 l\u00e0 cao v\u00e0 c\u00f3 th\u1ec3 l\u00e0 kh\u00f3 kh\u0103n cho c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 h\u1ea1n ch\u1ebf v\u1ec1 kinh t\u1ebf.<\/p>\n
T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Egudin 5?<\/h2>\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/td>\n Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n
\n
\n
Solifenacin succinate (ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a thu\u1ed1c Egudin 5) \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 ph\u00ea duy\u1ec7t v\u00e0o cu\u1ed1i n\u0103m 2004 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u00e0ng quang ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c.<\/li>\n
Solifenacin c\u1ea3i thi\u1ec7n t\u1ea5t c\u1ea3 c\u00e1c tri\u1ec7u ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2n \u0111ang \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1ec7nh vi\u00eam b\u00e0ng quang qu\u00e1 m\u1ee9c v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng. L\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 c\u00e1c giai \u0111o\u1ea1n kh\u1ea9n c\u1ea5p.<\/li>\n<\/ul>\n<\/td>\n
\n
\n
Gi\u00e1 th\u00e0nh s\u1ea3n ph\u1ea9m Solafinacin 5mg trong kho\u1ea3ng 600.000 cho 1 h\u1ed9p, m\u1ee9c gi\u00e1 n\u00e0y c\u00f3 v\u1ebb\u00a0 h\u01a1i cao so v\u1edbi c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t t\u01b0\u01a1ng \u0111\u01b0\u01a1ng.<\/li>\n
Thu\u1ed1c c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng l\u01b0\u1ee3ng \u0111\u1eddi s\u1ed1ng ng\u01b0\u1eddi s\u1eed d\u1ee5ng nh\u01b0 n\u00f4n, nh\u00ecn m\u1edd, \u0111au b\u1ee5ng\u2026<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
(1) Ca\u0301c gia\u0309 Maria Maniscalco, Devada Singh-Franco, William R Wolowich, Rolando Torres-Col\u00f3n. (Th\u1eddi gian ph\u00e1t h\u00e0nh N\u0103m 2006). Solifenacin succinate for the treatment of symptoms of overactive bladder.<\/em> Th\u1eddi gian truy c\u1eadp ng\u00e0y 30 th\u00e1ng 8 n\u0103m 2023, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/17062299\/<\/a>
\n(2)Ta\u0301c gia\u0309 J Pharmacol Sci. (Th\u1eddi gian ph\u00e1t h\u00e0nh n\u0103m 2010). The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorate effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes<\/em>. Th\u1eddi gian truy c\u1eadp ng\u00e0y 30 th\u00e1ng 8 n\u0103m 2023, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/20134114\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c Egudin 5- \u0110i\u1ec1u tr\u1ecb \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7<\/span><\/p>\n","protected":false},"author":1,"featured_media":40362,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-40360","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/40360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=40360"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/40362"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=40360"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=40360"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=40360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Th\u00e0nh ph\u1ea7n<\/h3>\nThu\u1ed1c Egudin 5 c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:\nHo\u1ea1t ch\u1ea5t:\nSolifenacin Succinate:\u00a0 5mg\nT\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean n\u00e9n.\nD\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h2>\nS\u0110K: QL\u0110B-681-18\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean.\nXu\u1ea5t x\u1ee9:\u00a0 Vi\u1ec7t Nam<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Egudin 5<\/h2>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Egudin 5<\/h2>\n

T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n

R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/h4>\nKh\u00f4 mi\u1ec7ng<\/p>\n

Th\u01b0\u1eddng g\u1eb7p<\/h4>\nNh\u00ecn m\u1edd, t\u00e1o b\u00f3n, kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n,ch\u1ee9ng kh\u00f3 ti\u00eau.<\/p>\n

Hi\u1ebfm g\u1eb7p<\/h4>\nTh\u1ea7n kinh: Ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.\nTi\u00eau h\u00f3a: T\u1eafc ngh\u1ebdn, ph\u00e2n r\u1eafn, n\u00f4n.\nDa: Ng\u1ee9a, n\u1ed5i ban.\nTh\u1eadn, ti\u1ebft ni\u1ec7u: B\u00ed ti\u1ec3u<\/p>\n

R\u1ea5t hi\u1ebfm g\u1eb7p<\/h4>\n\u1ea2o gi\u00e1c, r\u1ed1i lo\u1ea1n tinh th\u1ea7n, m\u00e0y \u0111ay, ph\u00f9 m\u1ea1ch.<\/p>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n
Thu\u1ed1c Egudin 5 c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:
\nHo\u1ea1t ch\u1ea5t:
\nSolifenacin Succinate:\u00a0 5mg
\nT\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean n\u00e9n.
\nD\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h2>\n
S\u0110K: QL\u0110B-681-18
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean.
\nXu\u1ea5t x\u1ee9:\u00a0 Vi\u1ec7t Nam<\/p>\n

R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/h4>\n
Kh\u00f4 mi\u1ec7ng<\/p>\n

Th\u01b0\u1eddng g\u1eb7p<\/h4>\n
Nh\u00ecn m\u1edd, t\u00e1o b\u00f3n, kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n,ch\u1ee9ng kh\u00f3 ti\u00eau.<\/p>\n

Hi\u1ebfm g\u1eb7p<\/h4>\n
Th\u1ea7n kinh: Ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.
\nTi\u00eau h\u00f3a: T\u1eafc ngh\u1ebdn, ph\u00e2n r\u1eafn, n\u00f4n.
\nDa: Ng\u1ee9a, n\u1ed5i ban.
\nTh\u1eadn, ti\u1ebft ni\u1ec7u: B\u00ed ti\u1ec3u<\/p>\n

R\u1ea5t hi\u1ebfm g\u1eb7p<\/h4>\n
\u1ea2o gi\u00e1c, r\u1ed1i lo\u1ea1n tinh th\u1ea7n, m\u00e0y \u0111ay, ph\u00f9 m\u1ea1ch.<\/p>\n