{"id":3719,"date":"2019-02-21T16:47:29","date_gmt":"2019-02-21T09:47:29","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?post_type=product&#038;p=3719"},"modified":"2025-07-24T14:48:52","modified_gmt":"2025-07-24T07:48:52","slug":"esperal","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/esperal\/","title":{"rendered":"Esperal 500mg"},"content":{"rendered":"<p><strong>Hi\u1ec7n nay c\u00f3 r\u1ea5t nhi\u1ec1u th\u00f4ng tin v\u1ec1 <a href=\"https:\/\/www.vnras.com\/drug\/esperal\">thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg<\/a> nh\u01b0ng ch\u01b0a \u0111\u1ea7y \u0111\u1ee7.\u00a0 Trong b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y, <a href=\"https:\/\/www.vnras.com\/drug\/\">nh\u00e0 thu\u1ed1c online L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n Esperal l\u00e0 thu\u1ed1c g\u00ec? Gi\u00e1 bao nhi\u00eau? Mua \u1edf \u0111\u00e2u?<\/strong><\/p>\n<h2>Thu\u1ed1c ESPERAL 500mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<p>Thu\u1ed1c Esperal 500mg l\u00e0 thu\u1ed1c\u00a0\u0111i\u1ec1u tr\u1ecb nghi\u1ec7n r\u01b0\u1ee3u m\u00e3n t\u00ednh, thu\u1ed1c c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0\u00a0<a href=\"https:\/\/www.vnras.com\/drug\/2019\/05\/disulfiram.html\">Disulfiram<\/a> h\u00e0m l\u01b0\u1ee3ng 500mg l\u00e0 ho\u1ea1t ch\u1ea5t \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c FDA Hoa k\u1ef3 c\u1ea5p ph\u00e9p \u0111i\u1ec1u tr\u1ecb nghi\u1ec7n r\u01b0\u1ee3u \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m Sanofi \u2013 Ph\u00e1p.<\/p>\n<ul>\n<li>D\u1ea1ng b\u00e0o ch\u1ebf: vi\u00ean n\u00e9n<\/li>\n<li>S\u1ed1 \u0111\u0103ng k\u00fd: VD-11342-10<\/li>\n<li>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i:\u00a0H\u1ed9p 20 vi\u00ean<\/li>\n<\/ul>\n<h2>Th\u00e0nh ph\u1ea7n<\/h2>\n<p><strong>Thu\u1ed1c Esperal 500mg <\/strong>c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0:<\/p>\n<ul>\n<li>Disulfiram: 500mg.<\/li>\n<li>Ngo\u00e0i ra c\u00f2n c\u00f3 c\u00e1c t\u00e1 d\u01b0\u1ee3c kh\u00e1c v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Esperal 500mg c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n<p><strong>Thu\u1ed1c Esperal 500mg c\u00f3 t\u00e1c d\u1ee5ng<\/strong> \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n b\u1ecb nghi\u1ec7n r\u01b0\u1ee3u m\u00e3n t\u00ednh. Thu\u1ed1c Esperal 500 mg ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a r\u01b0\u1ee3u trong c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n, t\u1eeb \u0111\u00f3 l\u00e0m xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00f3 ch\u1ecbu khi b\u1ec7nh nh\u00e2n u\u1ed1ng r\u01b0\u1ee3u, b\u1ec7nh nh\u00e2n s\u1ebd nhanh ch\u00f3ng b\u1ecb say h\u01a1n. Disulfiram (DSF) l\u00e0 m\u1ed9t ch\u1ea5t ch\u1ed1ng c\u1ed3n n\u1ed5i ti\u1ebfng c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf aldehyde dehydrogenase v\u00e0 g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng &#8216;n\u00f4n nao&#8217; c\u1ef1c \u0111\u1ed9 khi u\u1ed1ng v\u1edbi r\u01b0\u1ee3u.<\/p>\n<p>Disulfiram s\u1ebd t\u1ea1o ra ph\u1ea3n \u1ee9ng ph\u1ea3n \u1ee9ng v\u1edbi ethanol, th\u01b0\u1eddng \u1edf li\u1ec1u t\u1eeb 250 mg \/ ng\u00e0y \u0111\u1ebfn 500 mg \/ ng\u00e0y, m\u1eb7c d\u00f9 m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 kh\u00f4ng c\u00f3 ph\u1ea3n \u1ee9ng ph\u1ea3n \u1ee9ng \u1edf m\u1ee9c \u0111\u1ed9 n\u00e0y.\u00a0\u0110\u1ed9c t\u00ednh tr\u00ean tim, gan v\u00e0 th\u1ea7n kinh c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra trong ph\u1ea1m vi li\u1ec1u l\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p>M\u01b0\u1eddi m\u1ed9t th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u01b0\u1ee3c thu nh\u1eadn v\u1edbi t\u1ed5ng s\u1ed1 1.527 b\u1ec7nh nh\u00e2n.\u00a0H\u1ecd so s\u00e1nh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng disulfiram v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, kh\u00f4ng d\u00f9ng thu\u1ed1c ho\u1eb7c c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 ki\u00eang khem kh\u00e1c.\u00a0Nh\u00ecn chung, 6 nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o v\u1ec1 t\u00e1c d\u1ee5ng t\u1ed1t h\u01a1n \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi vi\u1ec7c ki\u00eang c\u1eef cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng disulfiram.\u00a0S\u00e1u trong s\u1ed1 9 nghi\u00ean c\u1ee9u \u0111o l\u01b0\u1eddng c\u00e1c k\u1ebft c\u1ee5c ph\u1ee5 \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng disulfiram c\u00f3 s\u1ed1 ng\u00e0y u\u1ed1ng nhi\u1ec1u h\u01a1n \u0111\u00e1ng k\u1ec3 cho \u0111\u1ebfn khi t\u00e1i ph\u00e1t v\u00e0 s\u1ed1 ng\u00e0y u\u1ed1ng r\u01b0\u1ee3u \u00edt h\u01a1n.\u00a0Ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o l\u00e0 v\u1eeba ph\u1ea3i.\u00a0S\u1ef1 kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t l\u00e0 \u0111\u00e1ng k\u1ec3 trong h\u1ea7u h\u1ebft c\u00e1c ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p, nh\u01b0ng k\u1ebft qu\u1ea3 h\u1ee3p l\u1ec7 \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a disulfiram so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c trong 12 th\u00e1ng v\u00e0 disulfiram kh\u00f4ng \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t so v\u1edbi \u0111i\u1ec1u tr\u1ecb kh\u00e1c ho\u1eb7c kh\u00f4ng.\u00a0Ph\u1ea7n l\u1edbn c\u00e1c nghi\u00ean c\u1ee9u quan tr\u1ecdng c\u00f3 th\u1eddi gian ng\u1eafn h\u01a1n.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u00f3 gi\u00e1m s\u00e1t b\u1eb1ng disulfiram c\u00f3 m\u1ed9t s\u1ed1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c ki\u00eang khem ng\u1eafn h\u1ea1n v\u00e0 s\u1ed1 ng\u00e0y cho \u0111\u1ebfn khi t\u00e1i ph\u00e1t c\u0169ng nh\u01b0 s\u1ed1 ng\u00e0y u\u1ed1ng r\u01b0\u1ee3u khi so s\u00e1nh v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, kh\u00f4ng d\u00f9ng thu\u1ed1c ho\u1eb7c c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c cho b\u1ec7nh nh\u00e2n nghi\u1ec7n ho\u1eb7c l\u1ea1m d\u1ee5ng r\u01b0\u1ee3u.\u00a0Hi\u1ec7u qu\u1ea3 l\u00e2u d\u00e0i \u0111\u1ed1i v\u1edbi vi\u1ec7c ki\u00eang khem v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1.\u00a0Tuy nhi\u00ean, c\u1ea7n c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u1ed3ng nh\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cao h\u01a1n trong t\u01b0\u01a1ng lai v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a disulfiram.<\/p>\n<h2>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h2>\n<p id=\"i-hap-thu\" class=\"ftwp-heading\"><em>H\u1ea5p thu<\/em><\/p>\n<p>Disulfiram \u0111\u01b0\u1ee3c h\u1ea5p thu ch\u1eadm \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a (80 \u0111\u1ebfn 90% li\u1ec1u u\u1ed1ng).<span class=\"\">\u00a0<\/span><\/p>\n<p id=\"i-phan-bo\" class=\"ftwp-heading\"><em>Ph\u00e2n b\u1ed1<\/em><\/p>\n<p>Sau khi u\u1ed1ng li\u1ec1uduy nh\u1ea5t 50, 100, 200 ho\u1eb7c 400 mg tr\u00ean kg, disulfiram \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y v\u1edbi s\u1ed1 l\u01b0\u1ee3ng ph\u1ee5 thu\u1ed9c v\u00e0o n\u1ed3ng \u0111\u1ed9 trong m\u00e1u, gan, th\u1eadn, l\u00e1 l\u00e1ch, n\u00e3o, c\u01a1 v\u00e0 m\u00f4 m\u1ee1 quanh m\u00e0o tinh \u1edf chu\u1ed9t. Sau khi d\u00f9ng 2 th\u00e1ng, vi\u1ec7c t\u00edch l\u0169y kh\u00f4ng l\u1ec7 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng, ch\u1ee9ng minh m\u1ed9t \u0111i\u1ec3m b\u00e3o h\u00f2a \u1edf nh\u1eefng c\u01a1 quan kh\u00e1c nhau.<\/p>\n<p id=\"i-chuyen-hoa\" class=\"ftwp-heading\"><em>Chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>Disulfiram \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1eadm \u1edf gan th\u00e0nh diethyldithiocarbamate , diethylamine v\u00e0 carbon disulfide. Sau 6 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c, 1\/3 disulfiram huy\u1ebft t\u01b0\u01a1ng d\u01b0\u1edbi d\u1ea1ng diethyldithiocarbamate .<\/p>\n<p id=\"i-thai-tru\" class=\"ftwp-heading\"><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>Th\u1ea3i tr\u1eeb ph\u1ea7n l\u1edbn qua th\u1eadn, \u1edf d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a. Nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a c\u0169ng \u0111\u01b0\u1ee3c th\u1edf ra \u1edfd\u1ea1ng carbon disulfide . Kho\u1ea3ng 20% li\u1ec1u \u1eed d\u1ee5ng \u1edf c\u01a1 th\u1ec3 trong 1 tu\u1ea7n ho\u1eb7c d\u00e0i h\u01a1n. Kho\u1ea3ng 5-20% li\u1ec1u s\u1eed d\u1ee5ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i trong ph\u00e2n.<\/p>\n<h2>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/h2>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg cho ng\u01b0\u1eddi qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c, ph\u1ee5 n\u1eef c\u00f3 thai, ng\u01b0\u1eddi u\u1ed1ng r\u01b0\u1ee3u ho\u1eb7c \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n trong 24 gi\u1edd tr\u01b0\u1edbc; b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c metronidazol, ng\u01b0\u1eddi b\u1ecb ng\u1ed9 \u0111\u1ed9c r\u01b0\u1ee3u, b\u1ec7nh nh\u00e2n b\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng, b\u1ec7nh nh\u00e2n b\u1ecb m\u1eafc b\u1ec7nh tim m\u1ea1ch, b\u1ec7nh lo\u1ea1n th\u1ea7n, b\u1ec7nh nh\u00e2n\u00a0c\u00f3 ti\u1ec1n s\u1eed b\u1ecb m\u1eafc b\u1ec7nh vi\u00eam da ti\u1ebfp x\u00fac v\u1edbi cao su ph\u1ea3i \u0111\u01b0\u1ee3c th\u1eed v\u1ec1 s\u1ef1 qu\u00e1 m\u1eabn v\u1edbi c\u00e1c d\u1eabn ch\u1ea5t thiuram tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c Esperal.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng thu\u1ed1c Esperal 500mg nh\u01b0 th\u1ebf n\u00e0o?<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Li\u1ec1u l\u01b0\u1ee3ng d\u00f9ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o nh\u01b0 sau:<\/p>\n<ul>\n<li>Giai \u0111o\u1ea1n \u0111\u1ea7u, cho b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg li\u1ec1u t\u1ed1i \u0111a 500 mg m\u1ed7i ng\u00e0y t\u1ee9c m\u1ed7i ng\u00e0y 1 vi\u00ean trong th\u1eddi gian t\u1eeb 1 \u0111\u1ebfn 2 tu\u1ea7n. Sau \u0111\u00f3, cho b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng li\u1ec1u duy tr\u00ec t\u1eeb 125 \u0111\u1ebfn 500 mg thu\u1ed1c m\u1ed7i ng\u00e0y, t\u00f9y v\u00e0o kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c g\u00e2y ra cho b\u1ec7nh nh\u00e2n. N\u00ean cho b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng thu\u1ed1c Esperal v\u00e0o bu\u1ed5i s\u00e1ng v\u00ec khi \u0111\u00f3 b\u1ec7nh nh\u00e2n c\u00f3 t\u00e2m l\u00fd v\u1edbi s\u1ef1 quy\u1ebft t\u00e2m cai r\u01b0\u1ee3u nh\u1ea5t trong ng\u00e0y. C\u00f3 th\u1ec3 cho b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng v\u00e0o bu\u1ed5i t\u1ed1i n\u1ebfu c\u00f3 t\u00ecnh tr\u1ea1ng ng\u1ee7 l\u01a1 m\u01a1.<\/li>\n<li>C\u1ea7n duy tr\u00ec, ki\u00ean tr\u00ec \u0111i\u1ec1u tr\u1ecb nghi\u1ec7n r\u01b0\u1ee3u cho b\u1ec7nh nh\u00e2n cho \u0111\u1ebfn khi b\u1ea3n th\u00e2n b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u01b0\u1ee3c s\u1ef1 ki\u1ec1m ch\u1ebf s\u1eed d\u1ee5ng r\u01b0\u1ee3u. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb nghi\u1ec7n r\u01b0\u1ee3u c\u00f3 th\u1ec3 k\u00e9o d\u00e0i h\u00e0ng th\u00e1ng th\u1eadm ch\u00ed c\u1ea3 n\u0103m li\u00ean t\u1ee5c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n m\u1edbi h\u1ebft nghi\u1ec7n r\u01b0\u1ee3u \u0111\u01b0\u1ee3c. B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 s\u1ebd b\u1ecb m\u1eabn c\u1ea3m v\u1edbi r\u01b0\u1ee3u k\u00e9o d\u00e0i t\u1edbi 14 ng\u00e0y sau l\u1ea7n u\u1ed1ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal l\u1ea7n cu\u1ed1i c\u00f9ng, v\u00ec t\u1ed1c \u0111\u1ed9 ph\u1ee5c h\u1ed3i aldehyd dehydrogenase trong c\u01a1 th\u1ec3 ch\u1eadm.<\/li>\n<\/ul>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p>Thu\u1ed1c Esperal 500mg \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng. Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg khi b\u1ec7nh nh\u00e2n ch\u01b0a ng\u1eebng s\u1eed d\u1ee5ng r\u01b0\u1ee3u \u0111\u01b0\u1ee3c qu\u00e1 12h. Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Esperal khi b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c hi\u1ec3u bi\u1ebft \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c c\u1ee7a h\u1ecd.<\/p>\n<h2>C\u00f4ng d\u1ee5ng &#8211; Ch\u1ec9 \u0111\u1ecbnh<\/h2>\n<p>\u0110\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi th\u01b0\u1eddng xuy\u00ean u\u1ed1ng r\u01b0\u1ee3u. Esperal gi\u00fap xu\u1ea5t hi\u1ec7n s\u1edbm nh\u1eefng bi\u1ec3u hi\u1ec7n c\u1ee7a say r\u01b0\u1ee3u t\u1eeb \u0111\u00f3 h\u1ea1n ch\u1ebf \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng r\u01b0\u1ee3u u\u1ed1ng v\u00e0o<\/p>\n<p>\u0110\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi g\u1eb7p t\u00ecnh tr\u1ea1ng nghi\u1ec7n r\u01b0\u1ee3u v\u00e0 nh\u1eefng ng\u01b0\u1eddi cai r\u01b0\u1ee3u, ch\u1ed1ng t\u00e1i nghi\u1ec7n r\u01b0\u1ee3u.<\/p>\n<h2>L\u01b0u v\u00e0 b\u1ea3o qu\u1ea3n khi d\u00f9ng thu\u1ed1c<\/h2>\n<h3>L\u01b0u \u00fd v\u00e0 th\u1eadn tr\u1ecdng<\/h3>\n<p>Khi b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal, b\u00e1c s\u0129 v\u00e0 d\u01b0\u1ee3c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n tr\u00e1nh d\u00f9ng c\u00e1c lo\u1ea1i siro ho, n\u01b0\u1edbc s\u1ed1t, gi\u1ea5m, b\u1ea5t k\u1ef3 ch\u1ebf ph\u1ea9m n\u00e0o c\u00f3 ch\u1ee9a r\u01b0\u1ee3u.<\/p>\n<p>Khi b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng b\u1ea5t k\u1ef3 s\u1ea3n ph\u1ea9m n\u00e0o c\u00f3 ch\u1ee9a r\u01b0\u1ee3u k\u1ec3 c\u1ea3 l\u00e0 d\u00f9ng ngo\u00e0i \u0111\u1ed1i v\u1edbi 1 s\u1ed1 lo\u1ea1i thu\u1ed1c xoa ho\u1eb7c thu\u1ed1c r\u1eeda c\u00f3 c\u1ed3n, k\u1ec3 c\u1ea3 n\u01b0\u1edbc th\u01a1m d\u00f9ng sau khi c\u1ea1o r\u00e2u v\u00e0 n\u01b0\u1edbc xoa l\u01b0ng, c\u00f3 th\u1ec3 \u0111\u1ee7 \u0111\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng disulfiram &#8211; r\u01b0\u1ee3u d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m cho b\u1ec7nh nh\u00e2n.<\/p>\n<p>Ph\u1ea3n \u1ee9ng gi\u1eefa disulfiram &#8211; r\u01b0\u1ee3u v\u1eabn c\u00f3 th\u1ec3 x\u1ea3y ra nhi\u1ec1u tu\u1ea7n sau khi b\u1ec7nh nh\u00e2n \u0111\u00e3 ng\u1eebng d\u00f9ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500 mg.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, b\u1ec7nh nh\u00e2n b\u1ecb thi\u1ec3u n\u0103ng tuy\u1ebfn gi\u00e1p, c\u01a1n \u0111\u1ed9ng kinh, th\u01b0\u01a1ng t\u1ed5n n\u00e3o, vi\u00eam th\u1eadn m\u1ea1n ho\u1eb7c c\u1ea5p t\u00ednh, x\u01a1 gan ho\u1eb7c suy gan, \u0111i\u1ec7n n\u00e3o \u0111\u1ed3 kh\u00f4ng b\u00ecnh th\u01b0\u1eddng, ho\u1eb7c nghi\u1ec7n nhi\u1ec1u lo\u1ea1i thu\u1ed1c c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500 mg.<\/p>\n<p>X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan (bao g\u1ed3m c\u1ea3 transaminase) n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u01b0\u1edbc khi<br \/>\nb\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c Esperal v\u00e0 sau \u0111\u00f3 \u0111\u1ecbnh k\u1ef3, \u0111\u1eb7c bi\u1ec7t trong 3 th\u00e1ng \u0111\u1ea7u khi d\u00f9ng thu\u1ed1c Esperal. Gi\u00e1 tr\u1ecb transaminase ph\u1ea3i cao h\u01a1n 3 l\u1ea7n gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng tr\u00ean, disulfiram n\u00ean \u0111\u01b0\u1ee3c r\u00fat ngay l\u1eadp t\u1ee9c v\u00e0 d\u1ee9t kho\u00e1t. Sau \u0111\u00f3, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd cho \u0111\u1ebfn khi b\u00ecnh th\u01b0\u1eddng h\u00f3a ch\u1ee9c n\u0103ng gan x\u00e9t nghi\u1ec7m.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn \u0111\u1ec3 b\u00e1o c\u00e1o c\u00e1c d\u1ea5u hi\u1ec7u ngay l\u1eadp t\u1ee9c nh\u01b0 suy nh\u01b0\u1ee3c, ch\u00e1n \u0103n, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng ho\u1eb7c icterus cho b\u00e1c s\u0129. \u0110i\u1ec1u tra bao g\u1ed3m ki\u1ec3m tra l\u00e2m s\u00e0ng v\u00e0 \u0111\u00e1nh gi\u00e1 sinh h\u1ecdc ch\u1ee9c n\u0103ng gan n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n ngay l\u1eadp t\u1ee9c.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o v\u1ec1 nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c Esperal 500mg.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa ho\u1eb7c c\u1ea7n ph\u1ea3i d\u1eebng cho tr\u1ebb b\u00fa khi m\u1eb9 s\u1eed d\u1ee5ng thu\u1ed1c do ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 kh\u1ea3 n\u0103ng \u0111i v\u00e0o s\u1eefa m\u1eb9 c\u1ee7a thu\u1ed1c.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c Esperal trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 r\u00e1o, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30 \u0111\u1ed9 C, \u0111\u1ec3 xa t\u1ea7m v\u1edbi c\u1ee7a tr\u1ebb em.<\/p>\n<h2>T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c Esperal 500 mg l\u00e0 g\u00ec?<\/h2>\n<p><strong>Thu\u1ed1c cai r\u01b0\u1ee3u Esperal<\/strong> g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n bao g\u1ed3m:<\/p>\n<p>M\u00f9i kh\u00f3 ch\u1ecbu \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh colostomies (do carbon sulphide), li\u1ec7t d\u01b0\u01a1ng, vi\u00eam gan, g\u00e2y ph\u00e1t ban d\u1ea1ng tr\u1ee9ng c\u00e1, b\u1ed3n ch\u1ed3n, nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, n\u1ed5i m\u00e0y \u0111ay, m\u1ec7t nh\u1ecdc, run, mi\u1ec7ng c\u00f3 v\u1ecb kim lo\u1ea1i, v\u00e0 r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u1eb9, \u0111\u1eb7c bi\u1ec7t trong 2 tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 s\u1ebd x\u1ea3y ra r\u00f5 r\u1ec7t h\u01a1n.<\/p>\n<p>R\u1ed1i lo\u1ea1n gan: C\u00e1c tr\u01b0\u1eddng h\u1ee3p vi\u00eam gan hi\u1ebfm g\u1eb7p, m\u1ed9t s\u1ed1 x\u1ea3y ra \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng nghi\u1ec7n r\u01b0\u1ee3u \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ch\u00e0m niken, bao g\u1ed3m c\u00e1c tr\u01b0\u1eddng h\u1ee3p vi\u00eam gan t\u1ed1i c\u1ea5p r\u1ea5t hi\u1ebfm.<\/p>\n<p>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: Vi\u00eam \u0111a d\u00e2y th\u1ea7n kinh chi d\u01b0\u1edbi, vi\u00eam d\u00e2y th\u1ea7n kinh th\u1ecb gi\u00e1c; R\u1ed1i lo\u1ea1n th\u1ea7n kinh, m\u1ea5t tr\u00ed nh\u1edb, nh\u1ea7m l\u1eabn, suy nh\u01b0\u1ee3c; \u0110au \u0111\u1ea7u, bu\u1ed3n ng\u1ee7.<\/p>\n<p>R\u1ed1i lo\u1ea1n da li\u1ec5u: D\u1ecb \u1ee9ng da, c\u00f3 th\u1ec3 theo \u0111\u1ed9 nh\u1ea1y ch\u00e9o v\u1edbi cao su l\u01b0u h\u00f3a.<\/p>\n<p>\u0110\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho b\u1ec7nh nh\u00e2n c\u1ea7n ph\u1ea3i khuy\u00ean ng\u0103n b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng r\u01b0\u1ee3u khi \u0111ang d\u00f9ng thu\u1ed1c Esperal.<\/p>\n<p>N\u1ebfu \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal m\u00e0 b\u1ec7nh nh\u00e2n l\u1ea1i ti\u1ebfp t\u1ee5c u\u1ed1ng r\u01b0\u1ee3u th\u00ec s\u1ebd x\u1ea3y ra ph\u1ea3n \u1ee9ng c\u1ee7a disulf\u1ec9am v\u1edbi r\u01b0\u1ee3u g\u00e2y ra c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 \u0111\u1ecf b\u1eebng m\u1eb7t, to\u00e1t m\u1ed3 h\u00f4i, bu\u1ed3n n\u00f4n, kh\u00f3 th\u1edf, \u0111au ng\u1ef1c, tr\u1ee5y tim m\u1ea1ch, nh\u1ed3i m\u00e1u c\u01a1 tim, ch\u00f3ng m\u1eb7t, \u0111\u1ed9ng kinh, \u0111au \u0111\u1ea7u v\u00e0 th\u1eadm ch\u00ed c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn m\u1ea5t m\u1ea1ng.<\/p>\n<h2>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h2>\n<table style=\"border-collapse: collapse;width: 100%;height: 84px\">\n<tbody>\n<tr style=\"height: 21px\">\n<td>T\u01b0\u01a1ng t\u00e1c<\/td>\n<td>H\u1eadu qu\u1ea3<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td>amprenavir<\/td>\n<td>Dung d\u1ecbch u\u1ed1ng Amprenavir ch\u1ee9a m\u1ed9t l\u01b0\u1ee3ng l\u1edbn propylene glycol.\u00a0Ti\u00eau th\u1ee5 \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n ho\u1eb7c c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a c\u1ed3n ho\u1eb7c propylene glycol trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi disulfiram \u0111\u00f4i khi c\u00f3 th\u1ec3 g\u00e2y ra ph\u1ea3n \u1ee9ng \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ph\u1ea3n \u1ee9ng disulfiram<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td>benznidazole<\/td>\n<td>K\u1ebft h\u1ee3p c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 g\u00e2y nh\u1ea7m l\u1eabn v\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng lo\u1ea1n th\u1ea7n nh\u01b0 \u1ea3o t\u01b0\u1edfng v\u00e0 \u1ea3o gi\u00e1c \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n.<\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td>ethanol<\/td>\n<td>B\u1ea1n kh\u00f4ng n\u00ean u\u1ed1ng \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n ho\u1eb7c s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ch\u1ee9a ethanol trong khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng disulfiram.\u00a0\u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ecf m\u1eb7t, bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n, m\u1edd m\u1eaft, kh\u00f3 th\u1edf, tim \u0111\u1eadp nhanh v\u00e0 huy\u1ebft \u00e1p th\u1ea5p<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><strong>Qu\u00e1 li\u1ec1u, qu\u00ean li\u1ec1u v\u00e0 c\u00e1ch x\u1eed tr\u00ed<\/strong><\/h2>\n<h3>Qu\u00e1 li\u1ec1u<\/h3>\n<p>Khi s\u1eed d\u1ee5ng thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg qu\u00e1 li\u1ec1u b\u1ec7nh nh\u00e2n s\u1ebd c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng sau \u0111\u00e2y: r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a v\u00e0 n\u00f4n, \u0111i\u1ec7n n\u00e3o \u0111\u1ed3 kh\u00f4ng b\u00ecnh th\u01b0\u1eddng, ng\u1ee7 l\u01a1 m\u01a1, thay \u0111\u1ed5i \u00fd th\u1ee9c, \u1ea3o gi\u00e1c, suy gi\u1ea3m kh\u1ea3 n\u0103ng n\u00f3i, m\u1ea5t ph\u1ed1i h\u1ee3p, v\u00e0 h\u00f4n m\u00ea.<\/p>\n<p>C\u00e1ch x\u1eed tr\u00ed: \u0110\u01b0a ngay b\u1ec7nh nh\u00e2n \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 \u0111\u01b0\u1ee3c b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb. C\u00e1ch \u0111i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u Esperal 500mg l\u00e0 h\u00fat, r\u1eeda d\u1ea1 d\u00e0y, k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/p>\n<h3>Qu\u00ean li\u1ec1u<\/h3>\n<p>Tr\u00e1nh qu\u00ean li\u1ec1u; n\u1ebfu qu\u00ean li\u1ec1u, b\u1ec7nh nh\u00e2n c\u1ea7n b\u1ecf qua li\u1ec1u \u0111\u00e3 qu\u00ean, kh\u00f4ng u\u1ed1ng g\u1ea5p li\u1ec1u v\u1edbi li\u1ec1u ti\u1ebfp theo.<\/p>\n<p>Kh\u00f4ng n\u00ean b\u1ecf li\u1ec1u qu\u00e1 2 l\u1ea7n li\u00ean ti\u1ebfp.<\/p>\n<h2>Thu\u1ed1c ESPERAL 500mg gi\u00e1 bao nhi\u00eau?<\/h2>\n<p><strong>Thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg gi\u00e1 bao nhi\u00eau? <\/strong>Hi\u1ec7n thu\u1ed1c\u00a0c\u00f3 gi\u00e1 350.000 VN\u0110 m\u1ed9t h\u1ed9p. Gi\u00e1 th\u00e0nh c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u00f9y v\u00e0o t\u1eebng nh\u00e0 thu\u1ed1c.<\/p>\n<h2>Thu\u1ed1c ESPERAL 500mg mua \u1edf \u0111\u00e2u?<\/h2>\n<p>Hi\u1ec7n nay s\u1ea3n ph\u1ea9m \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i <a href=\"https:\/\/www.vnras.com\/drug\/\">nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng<\/a>, ch\u00fang t\u00f4i giao h\u00e0ng tr\u00ean to\u00e0n qu\u1ed1c.<\/p>\n<p>C\u1ea7n li\u00ean h\u1ec7 nh\u1eefng c\u01a1 s\u1edf uy t\u00edn \u0111\u1ec3 mua \u0111\u01b0\u1ee3c s\u1ea3n ph\u1ea9m Esperal t\u1ed1t nh\u1ea5t, tr\u00e1nh vi\u1ec7c mua ph\u1ea3i c\u00e1c s\u1ea3n ph\u1ea9m k\u00e9m ch\u1ea5t l\u01b0\u1ee3ng.<\/p>\n<h2>Ngu\u1ed3n t\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>\n<p class=\"heading-title\">T\u00e1c gi\u1ea3: Charlotte,The efficacy of disulfiram for the treatment of alcohol use disorder, NCBI, Truy c\u1eadp 08\/09\/2022.<\/p>\n<\/li>\n<li>T\u00e1c gi\u1ea3: E W Larson, Disulfiram treatment of patients with both alcohol dependence and other psychiatric disorders: a review, NCBI, Truy c\u1eadp 08\/09\/2022.<\/li>\n<li>Medically reviewed by\u00a0Carmen Fookes, BPharm. <a href=\"https:\/\/www.drugs.com\/disulfiram.html\" rel=\"noopener\">Disulfiram<\/a> Last updated on Jul 6, 2022. Truy c\u1eadp 08\/09\/2022..<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Hi\u1ec7n nay c\u00f3 r\u1ea5t nhi\u1ec1u th\u00f4ng tin v\u1ec1 thu\u1ed1c cai r\u01b0\u1ee3u Esperal 500mg nh\u01b0ng ch\u01b0a \u0111\u1ea7y \u0111\u1ee7.\u00a0 Trong b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y, nh\u00e0 thu\u1ed1c online L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n Esperal l\u00e0 thu\u1ed1c g\u00ec? Gi\u00e1 bao nhi\u00eau? Mua \u1edf \u0111\u00e2u? Thu\u1ed1c ESPERAL 500mg l\u00e0 thu\u1ed1c g\u00ec? Thu\u1ed1c Esperal 500mg l\u00e0 thu\u1ed1c\u00a0\u0111i\u1ec1u tr\u1ecb [&#8230;]\n","protected":false},"author":1,"featured_media":33874,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-3719","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/3719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=3719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/33874"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=3719"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=3719"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=3719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}