{"id":164930,"date":"2026-11-13T16:03:31","date_gmt":"2026-11-13T09:03:31","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=164930"},"modified":"2026-11-13T16:05:44","modified_gmt":"2026-11-13T09:05:44","slug":"thuoc-ratida-400mg-250ml","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-ratida-400mg-250ml\/","title":{"rendered":"Ratida 400mg\/250ml"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Ratida 400mg\/250ml \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi KRKA, D.D., . Novo Mesto c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 383115786624 (S\u0110K c\u0169: VN-22380-19)<\/b><\/p>\n<h2>Ratida 400mg\/250ml l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i 250ml dung d\u1ecbch <b>Ratida 400mg\/250ml<\/b> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Moxifloxacin (d\u01b0\u1edbi d\u1ea1ng Moxifloxacin hydrochlorid): 400mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Dung d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 383115786624 (S\u0110K c\u0169: VN-22380-19)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 chai x 250ml<\/p>\n<p>Xu\u1ea5t x\u1ee9: Slovenia<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Ratida 400mg\/250ml<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>\u0110\u1ec3 ph\u00e1t tri\u1ec3n v\u00e0 duy tr\u00ec v\u1eadt li\u1ec7u di truy\u1ec1n, vi khu\u1ea9n c\u1ea7n \u0111\u1ebfn s\u1ef1 tham gia c\u1ee7a hai enzym topoisomerase type II l\u00e0 DNA gyrase v\u00e0 topoisomerase IV. Moxifloxacin c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf \u0111\u1ed3ng th\u1eddi c\u1ea3 hai enzym n\u00e0y, t\u1eeb \u0111\u00f3 c\u1ea3n tr\u1edf c\u00e1c qu\u00e1 tr\u00ecnh sao ch\u00e9p, phi\u00ean m\u00e3 v\u00e0 s\u1eeda ch\u1eefa DNA c\u1ee7a vi khu\u1ea9n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Sau khi truy\u1ec1n t\u0129nh m\u1ea1ch 400mg moxifloxacin trong 60 ph\u00fat, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t kho\u1ea3ng 4,1mg\/l v\u00e0o cu\u1ed1i th\u1eddi gian truy\u1ec1n, cao h\u01a1n 26% so v\u1edbi \u0111\u01b0\u1eddng u\u1ed1ng c\u00f9ng li\u1ec1u (3,1mg\/l). AUC t\u01b0\u01a1ng \u1ee9ng l\u00e0 39mg.h\/l v\u00e0 35mg.h\/l, cho th\u1ea5y sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a thu\u1ed1c \u0111\u1ea1t kho\u1ea3ng 91%. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a moxifloxacin \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 b\u1edfi tu\u1ed5i v\u00e0 gi\u1edbi t\u00ednh, do \u0111\u00f3 kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u theo c\u00e1c y\u1ebfu t\u1ed1 n\u00e0y. Thu\u1ed1c c\u00f3 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u 50-1200mg khi u\u1ed1ng m\u1ed9t li\u1ec1u duy nh\u1ea5t, t\u1ed1i \u0111a 600mg khi truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t l\u1ea7n v\u00e0 600mg\/ng\u00e0y trong 10 ng\u00e0y li\u00ean ti\u1ebfp.<\/p>\n<p>V\u1edbi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (Vss) kho\u1ea3ng 2 l\/kg, moxifloxacin c\u00f3 kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp nhanh v\u00e0o c\u00e1c m\u00f4 v\u00e0 khoang ngo\u1ea1i b\u00e0o. Thu\u1ed1c g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u1edf m\u1ee9c 40-42%, ch\u1ee7 y\u1ebfu l\u00e0 albumin, trong \u0111\u00f3 t\u1ef7 l\u1ec7 li\u00ean k\u1ebft kh\u00f4ng thay \u0111\u1ed5i theo n\u1ed3ng \u0111\u1ed9.<\/p>\n<p>Kh\u1ea3 n\u0103ng ph\u00e2n b\u1ed1 c\u1ee7a moxifloxacin \u0111\u01b0\u1ee3c ghi nh\u1eadn t\u1ea1i nhi\u1ec1u v\u1ecb tr\u00ed kh\u00e1c nhau. Sau khi u\u1ed1ng kho\u1ea3ng 2,2 gi\u1edd, n\u1ed3ng \u0111\u1ed9 trung b\u00ecnh trong ni\u00eam m\u1ea1c ph\u1ebf qu\u1ea3n v\u00e0 d\u1ecbch l\u00f3t bi\u1ec3u m\u00f4 l\u1ea7n l\u01b0\u1ee3t l\u00e0 5,4mg\/kg v\u00e0 20,7mg\/l; ri\u00eang t\u1ea1i \u0111\u1ea1i th\u1ef1c b\u00e0o ph\u1ebf nang, n\u1ed3ng \u0111\u1ed9 c\u00f3 th\u1ec3 \u0111\u1ea1t 56,7mg\/kg. Sau 10 gi\u1edd truy\u1ec1n t\u0129nh m\u1ea1ch, thu\u1ed1c hi\u1ec7n di\u1ec7n trong d\u1ecbch b\u00f3ng n\u01b0\u1edbc tr\u00ean da v\u1edbi n\u1ed3ng \u0111\u1ed9 1,75mg\/l. \u0110\u1ed1i v\u1edbi d\u1ecbch k\u1ebd, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1edf d\u1ea1ng t\u1ef1 do t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi huy\u1ebft t\u01b0\u01a1ng v\u00e0 \u0111\u1ea1t m\u1ee9c cao nh\u1ea5t kho\u1ea3ng 1,0mg\/l sau 1,8 gi\u1edd truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n<p>Thay v\u00ec tr\u1ea3i qua chuy\u1ec3n h\u00f3a oxy h\u00f3a, moxifloxacin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a theo con \u0111\u01b0\u1eddng pha II v\u00e0 \u0111\u00e0o th\u1ea3i d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c g\u1ed1c ch\u01b0a bi\u1ebfn \u0111\u1ed5i c\u00f9ng hai d\u1ea1ng li\u00ean h\u1ee3p l\u00e0 glucuronid (M2) v\u00e0 sulpho (M1) th\u00f4ng qua m\u1eadt\/ph\u00e2n (chi\u1ebfm kho\u1ea3ng 60%) v\u00e0 \u0111\u01b0\u1eddng th\u1eadn (chi\u1ebfm kho\u1ea3ng 40%). \u0110\u1ed1i v\u1edbi c\u01a1 th\u1ec3 ng\u01b0\u1eddi, M1 v\u00e0 M2 tuy l\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh nh\u01b0ng l\u1ea1i b\u1ea5t ho\u1ea1t \u0111\u1ed1i v\u1edbi vi khu\u1ea9n. Ngo\u00e0i ra, c\u00e1c kh\u1ea3o s\u00e1t in vitro v\u00e0 l\u00e2m s\u00e0ng pha I cho th\u1ea5y ho\u1ea1t ch\u1ea5t n\u00e0y kh\u00f4ng t\u1ea1o ra t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u1edbi nh\u00f3m thu\u1ed1c chuy\u1ec3n h\u00f3a pha I ph\u1ee5 thu\u1ed9c h\u1ec7 enzym cytochrom P450.<\/p>\n<p>Sau khi s\u1eed d\u1ee5ng li\u1ec1u 400mg, \u0111\u1ed9 thanh th\u1ea3i to\u00e0n ph\u1ea7n trung b\u00ecnh c\u1ee7a moxifloxacin \u0111\u1ea1t t\u1eeb 179 \u0111\u1ebfn 246 mL\/ph\u00fat v\u00e0 ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i x\u1ea5p x\u1ec9 12 gi\u1edd. V\u1edbi li\u1ec1u truy\u1ec1n t\u0129nh m\u1ea1ch 400mg, c\u00f3 kho\u1ea3ng 98% t\u1ed5ng li\u1ec1u (t\u00ednh c\u1ea3 d\u1ea1ng nguy\u00ean v\u1eb9n v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a) \u0111\u01b0\u1ee3c thu h\u1ed3i, bao g\u1ed3m kho\u1ea3ng 26% th\u1ea3i tr\u1eeb qua ph\u00e2n v\u00e0 22% b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a. D\u1eef li\u1ec7u \u0111\u1ed9 thanh th\u1ea3i th\u1eadn n\u1eb1m trong ng\u01b0\u1ee1ng 24-53 mL\/ph\u00fat ch\u1ee9ng t\u1ecf m\u1ed9t ph\u1ea7n ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c t\u00e1i h\u1ea5p thu tr\u1edf l\u1ea1i \u1edf \u1ed1ng th\u1eadn, \u0111\u1ed3ng th\u1eddi th\u00f4ng s\u1ed1 thanh th\u1ea3i th\u1eadn c\u1ee7a thu\u1ed1c g\u1ed1c ho\u00e0n to\u00e0n kh\u00f4ng b\u1ecb thay \u0111\u1ed5i khi d\u00f9ng k\u00e8m probenecid hay ranitidin.<\/p>\n<h2>Thu\u1ed1c Ratida 400mg\/250ml \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb vi\u00eam ph\u1ed5i c\u1ed9ng \u0111\u1ed3ng c\u00f3 nguy\u00ean nh\u00e2n t\u1eeb c\u00e1c ch\u1ee7ng vi khu\u1ea9n c\u00f2n nh\u1ea1y c\u1ea3m. B\u00ean c\u1ea1nh \u0111\u00f3, thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho c\u00e1c t\u00ecnh tr\u1ea1ng nhi\u1ec5m khu\u1ea9n da v\u00e0 m\u00f4 m\u1ec1m m\u1ee9c \u0111\u1ed9 ph\u1ee9c t\u1ea1p (k\u1ec3 c\u1ea3 bi\u1ebfn ch\u1ee9ng nhi\u1ec5m khu\u1ea9n b\u00e0n ch\u00e2n \u1edf ng\u01b0\u1eddi b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng), c\u0169ng nh\u01b0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n \u1ed5 b\u1ee5ng ph\u1ee9c t\u1ea1p, bao g\u1ed3m c\u1ea3 nhi\u1ec5m khu\u1ea9n \u0111a t\u00e1c nh\u00e2n nh\u01b0 \u1ed5 \u00e1p xe.<\/p>\n<figure id=\"attachment_164936\" aria-describedby=\"caption-attachment-164936\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-164936\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml.jpg\" alt=\"Ratida 400mg\/250ml\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-250ml-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-164936\" class=\"wp-caption-text\">Thu\u1ed1c Ratida 400mg\/250ml tr\u1ecb nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>S\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn v\u1edbi m\u1ee9c li\u1ec1u chu\u1ea9n 400mg\/l\u1ea7n\/ng\u00e0y (t\u01b0\u01a1ng \u1ee9ng 250 mL dung d\u1ecbch truy\u1ec1n ho\u1eb7c 1 vi\u00ean n\u00e9n bao phim) cho t\u1ea5t c\u1ea3 c\u00e1c ch\u1ec9 \u0111\u1ecbnh \u0111\u00e3 n\u00eau.<\/p>\n<p>Th\u1eddi l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1ed9 n\u1eb7ng c\u1ee7a t\u00ecnh tr\u1ea1ng nhi\u1ec5m khu\u1ea9n v\u00e0 ti\u1ebfn tri\u1ec3n l\u00e2m s\u00e0ng. Li\u1ec7u tr\u00ecnh c\u00f3 th\u1ec3 kh\u1edfi \u0111\u1ea7u b\u1eb1ng truy\u1ec1n t\u0129nh m\u1ea1ch r\u1ed3i chuy\u1ec3n ti\u1ebfp sang \u0111\u01b0\u1eddng u\u1ed1ng khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng (\u00e1p d\u1ee5ng cho nhi\u1ec5m khu\u1ea9n h\u00f4 h\u1ea5p tr\u00ean v\u00e0 d\u01b0\u1edbi).<\/p>\n<p>T\u1ed5ng th\u1eddi gian khuy\u1ebfn c\u00e1o cho ph\u00e1c \u0111\u1ed3 n\u1ed1i ti\u1ebfp (truy\u1ec1n t\u0129nh m\u1ea1ch sau \u0111\u00f3 d\u00f9ng vi\u00ean u\u1ed1ng) \u0111\u01b0\u1ee3c ph\u00e2n chia theo t\u1eebng b\u1ec7nh l\u00fd: t\u1eeb 7 \u0111\u1ebfn 14 ng\u00e0y \u0111\u1ed1i v\u1edbi vi\u00eam ph\u1ed5i c\u1ed9ng \u0111\u1ed3ng; dao \u0111\u1ed9ng trong kho\u1ea3ng 7-21 ng\u00e0y cho nhi\u1ec5m khu\u1ea9n da v\u00e0 t\u1ed5 ch\u1ee9c d\u01b0\u1edbi da ph\u1ee9c t\u1ea1p; v\u00e0 t\u1eeb 5-14 ng\u00e0y cho c\u00e1c ca nhi\u1ec5m khu\u1ea9n \u1ed5 b\u1ee5ng ph\u1ee9c t\u1ea1p (C\u1ea7n tu\u00e2n th\u1ee7 \u0111\u00fang gi\u1edbi h\u1ea1n th\u1eddi gian n\u00eau tr\u00ean, kh\u00f4ng k\u00e9o d\u00e0i th\u00eam)<\/p>\n<p><b><i>Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean: <\/i><\/b>Do hi\u1ec7u l\u1ef1c l\u00e2m s\u00e0ng c\u1ee7a moxifloxacin \u1edf l\u1ee9a tu\u1ed5i n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh, nh\u00e0 s\u1ea3n xu\u1ea5t kh\u00f4ng \u0111\u01b0a ra khuy\u1ebfn c\u00e1o li\u1ec1u d\u00f9ng c\u1ee5 th\u1ec3. Ri\u00eang v\u1edbi nh\u00f3m tr\u1ebb d\u01b0\u1edbi 6 tu\u1ed5i, t\u00ednh an to\u00e0n Ratida v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh<\/p>\n<p><b><i>Ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t ch\u1ee7ng t\u1ed9c: <\/i><\/b>C\u1ea3 hai nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y \u0111\u1ec1u \u00e1p d\u1ee5ng m\u1ee9c li\u1ec1u th\u00f4ng th\u01b0\u1eddng m\u00e0 kh\u00f4ng \u0111\u00f2i h\u1ecfi s\u1ef1 \u0111i\u1ec1u ch\u1ec9nh n\u00e0o.<\/p>\n<p><b><i>Suy gi\u1ea3m ch\u1ee9c n\u0103ng gan: <\/i><\/b>Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 t\u1ed5n th\u01b0\u01a1ng gan v\u1eabn duy tr\u00ec li\u1ec1u d\u00f9ng ti\u00eau chu\u1ea9n tuy nhi\u00ean v\u1eabn c\u00f3 nh\u1eefng th\u1eadn tr\u1ecdng nh\u1ea5t \u0111\u1ecbnh<\/p>\n<p><b><i>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn:<\/i><\/b> M\u1ee9c li\u1ec1u gi\u1eef nguy\u00ean cho to\u00e0n b\u1ed9 b\u1ec7nh nh\u00e2n suy th\u1eadn \u1edf m\u1ecdi c\u1ea5p \u0111\u1ed9, t\u00ednh c\u1ea3 nh\u00f3m c\u00f3 h\u1ec7 s\u1ed1 thanh th\u1ea3i creatinin \u2264 30ml\/ph\u00fat\/1,73m\u00b2 hay \u0111ang ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o \u0111\u1ecbnh k\u1ef3 (th\u1ea9m t\u00e1ch m\u00e1u) v\u00e0 th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c ngo\u1ea1i tr\u00fa.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Dung d\u1ecbch Ratida 400mg\/250ml \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch<\/p>\n<p>Ti\u1ebfn h\u00e0nh truy\u1ec1n t\u0129nh m\u1ea1ch thu\u1ed1c v\u1edbi t\u1ed1c \u0111\u1ed9 sao cho t\u1ed5ng th\u1eddi gian truy\u1ec1n l\u1edbn h\u01a1n 60 ph\u00fat. C\u00f3 th\u1ec3 truy\u1ec1n \u0111\u01a1n \u0111\u1ed9c ho\u1eb7c d\u1eabn qua \u1ed1ng ch\u1eef T c\u00f9ng c\u00e1c dung d\u1ecbch t\u01b0\u01a1ng th\u00edch.<\/p>\n<p>C\u00e1c dung d\u1ecbch d\u01b0\u1edbi \u0111\u00e2y khi pha tr\u1ed9n c\u00f9ng dung d\u1ecbch Ratida \u0111\u1ec1u gi\u1eef \u0111\u01b0\u1ee3c t\u00ednh \u1ed5n \u0111\u1ecbnh \u00edt nh\u1ea5t 24 gi\u1edd \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng n\u00ean ho\u00e0n to\u00e0n t\u01b0\u01a1ng th\u00edch khi truy\u1ec1n chung: n\u01b0\u1edbc c\u1ea5t pha ti\u00eam; Natri Clorid (0,9%, 1 M); Glucose (5%, 10%, 40%); Xylit 20%; Ringer v\u00e0 Lactated Ringer.<\/p>\n<p>L\u01b0u \u00fd an to\u00e0n: Kh\u00f4ng truy\u1ec1n chung dung d\u1ecbch Ratida v\u1edbi b\u1ea5t k\u1ef3 thu\u1ed1c n\u00e0o kh\u00e1c m\u00e0 ph\u1ea3i t\u00e1ch ri\u00eang t\u1eebng \u0111\u01b0\u1eddng truy\u1ec1n v\u00e0 tuy\u1ec7t \u0111\u1ed1i ch\u1ec9 s\u1eed d\u1ee5ng c\u00e1c chai thu\u1ed1c c\u00f3 dung d\u1ecbch trong su\u1ed1t.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Ratida 400mg\/250ml trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Kh\u00f4ng ti\u00eam truy\u1ec1n <b>dung d\u1ecbch Ratida 400mg\/250ml<\/b> cho ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi moxifloxacin, t\u00e1 d\u01b0\u1ee3c hay c\u00e1c kh\u00e1ng sinh thu\u1ed9c nh\u00f3m quinolon kh\u00e1c<\/p>\n<p>Ph\u1ee5 n\u1eef trong thai k\u1ef3, trong th\u1eddi k\u1ef3 cho con b\u00fa, tr\u1ebb nh\u1ecf v\u00e0 ng\u01b0\u1eddi ch\u01b0a th\u00e0nh ni\u00ean (d\u01b0\u1edbi 18 tu\u1ed5i)<\/p>\n<p>Ng\u01b0\u1eddi t\u1eebng xu\u1ea5t hi\u1ec7n t\u1ed5n th\u01b0\u01a1ng g\u00e2n c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh quinolon.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 c\u00e1c b\u1ea5t th\u01b0\u1eddng v\u1ec1 tim m\u1ea1ch ho\u1eb7c \u0111i\u1ec7n gi\u1ea3i l\u00e0m t\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, bao g\u1ed3m QT k\u00e9o d\u00e0i b\u1ea9m sinh, h\u1ea1 kali m\u00e1u ch\u01b0a \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh, nh\u1ecbp tim ch\u1eadm c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng, suy tim c\u00f3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng v\u00e0 ti\u1ec1n s\u1eed r\u1ed1i lo\u1ea1n nh\u1ecbp tim.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan ho\u1eb7c c\u00f3 ch\u1ec9 s\u1ed1 transaminase v\u01b0\u1ee3t qu\u00e1 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a m\u1ee9c b\u00ecnh th\u01b0\u1eddng (ULN).<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng moxifloxacin khi \u0111\u00e3 c\u00e2n nh\u1eafc k\u1ef9 l\u1ee3i \u00edch v\u00e0 nguy c\u01a1, \u0111\u1eb7c bi\u1ec7t khi c\u00f2n l\u1ef1a ch\u1ecdn kh\u00e1ng sinh thay th\u1ebf. Tr\u00e1nh d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n t\u1eebng g\u1eb7p ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng v\u1edbi quinolon ho\u1eb7c fluoroquinolon.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ph\u00ecnh, b\u00f3c t\u00e1ch \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ho\u1eb7c b\u1ec7nh l\u00fd van tim, \u0111\u1eb7c bi\u1ec7t ng\u01b0\u1eddi cao tu\u1ed5i, ng\u01b0\u1eddi t\u0103ng huy\u1ebft \u00e1p, m\u1eafc b\u1ec7nh m\u00f4 li\u00ean k\u1ebft ho\u1eb7c \u0111ang d\u00f9ng corticosteroid to\u00e0n th\u00e2n.<\/p>\n<p>Kh\u00f4ng truy\u1ec1n t\u0129nh m\u1ea1ch nhanh, th\u1eddi gian truy\u1ec1n t\u1ed1i thi\u1ec3u 60 ph\u00fat v\u00e0 li\u1ec1u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 400 mg \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT. Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi c\u00f3 r\u1ed1i lo\u1ea1n nh\u1ecbp tim, nh\u1ecbp tim ch\u1eadm, h\u1ea1 kali m\u00e1u ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>Ng\u1eebng thu\u1ed1c ngay khi xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u qu\u00e1 m\u1eabn nghi\u00eam tr\u1ecdng, ph\u1ea3n \u1ee9ng da n\u1eb7ng ho\u1eb7c c\u00e1c bi\u1ec3u hi\u1ec7n b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng kh\u00e1c.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed co gi\u1eadt, r\u1ed1i lo\u1ea1n th\u1ea7n kinh trung \u01b0\u01a1ng, b\u1ec7nh t\u00e2m th\u1ea7n ho\u1eb7c nh\u01b0\u1ee3c c\u01a1.<\/p>\n<p>Theo d\u00f5i ch\u1ee9c n\u0103ng gan khi xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u nghi ng\u1edd t\u1ed5n th\u01b0\u01a1ng gan; ng\u1eebng thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 y t\u1ebf n\u1ebfu c\u00f3 bi\u1ec3u hi\u1ec7n vi\u00eam gan ti\u1ebfn tri\u1ec3n.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi cao tu\u1ed5i b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, \u0111\u1eb7c bi\u1ec7t khi kh\u00f4ng \u0111\u1ea3m b\u1ea3o \u0111\u1ee7 l\u01b0\u1ee3ng d\u1ecbch \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3.<\/p>\n<p>Theo d\u00f5i \u0111\u01b0\u1eddng huy\u1ebft ch\u1eb7t ch\u1ebd \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, nh\u1ea5t l\u00e0 khi ph\u1ed1i h\u1ee3p v\u1edbi insulin ho\u1eb7c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi thi\u1ebfu h\u1ee5t glucose-6-phosphat dehydrogenase (G6PD) do nguy c\u01a1 tan m\u00e1u.<\/p>\n<p>Tr\u00e1nh ti\u1ebfp x\u00fac v\u1edbi tia UV v\u00e0 \u00e1nh s\u00e1ng m\u1ea1nh trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng dung d\u1ecbch moxifloxacin b\u1eb1ng \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch, kh\u00f4ng truy\u1ec1n qua \u0111\u1ed9ng m\u1ea1ch.<\/p>\n<p>Thu\u1ed1c ch\u1ee9a 885,52 mg natri m\u1ed7i li\u1ec1u, c\u1ea7n l\u01b0u \u00fd \u1edf b\u1ec7nh nh\u00e2n ph\u1ea3i ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng mu\u1ed1i trong ch\u1ebf \u0111\u1ed9 \u0103n.<\/p>\n<p>Moxifloxacin c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a vi khu\u1ea9n Mycobacterium spp., d\u1eabn \u0111\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y lao \u00e2m t\u00ednh gi\u1ea3.<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng moxifloxacin trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n do t\u1ee5 c\u1ea7u v\u00e0ng kh\u00e1ng methicillin (MRSA).<\/p>\n<p>Hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c l\u1eadp \u0111\u1ed1i v\u1edbi b\u1ecfng n\u1eb7ng, vi\u00eam c\u00e2n m\u1ea1c v\u00e0 nhi\u1ec5m tr\u00f9ng b\u00e0n ch\u00e2n do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng k\u00e8m vi\u00eam x\u01b0\u01a1ng t\u1ee7y.<\/p>\n<h3>Ratida 400mg\/250ml t\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ph\u1ea3n \u1ee9ng t\u1ea1i v\u1ecb tr\u00ed ti\u00eam ho\u1eb7c truy\u1ec1n, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u, t\u0103ng men transaminase, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, b\u1ed9i nhi\u1ec5m n\u1ea5m do vi khu\u1ea9n v\u00e0 n\u1ea5m kh\u00e1ng thu\u1ed1c (vi\u00eam mi\u1ec7ng, vi\u00eam \u00e2m \u0111\u1ea1o do Candida), n\u00f4n, \u0111au b\u1ee5ng, k\u00e9o d\u00e0i kho\u1ea3ng QT \u1edf b\u1ec7nh nh\u00e2n h\u1ea1 kali m\u00e1u.<\/p>\n<p>\u00cdt g\u1eb7p: \u0110au c\u01a1, ph\u00e1t ban, t\u0103ng amylase, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, t\u00e1o b\u00f3n, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, thi\u1ebfu m\u00e1u, d\u1ecb c\u1ea3m, \u0111au kh\u1edbp, t\u0103ng lipid m\u00e1u, kh\u00f3 th\u1edf, m\u1ea5t ng\u1ee7, t\u0103ng bilirubin, ng\u1ee9a, gi\u1ea3m ti\u1ec3u c\u1ea7u, \u0111\u1ea7y h\u01a1i, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, t\u0103ng huy\u1ebft \u00e1p, m\u00e0y \u0111ay, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, \u0111au l\u01b0ng, gi\u1ea3m c\u1ea3m gi\u00e1c ngon mi\u1ec7ng, rung, r\u1ed1i lo\u1ea1n c\u1ea3m gi\u00e1c, t\u0103ng phosphatase ki\u1ec1m m\u00e1u, vi\u00eam d\u1ea1 d\u00e0y ru\u1ed9t, t\u0103ng gamma-glutamyl-transferase, k\u00e9o d\u00e0i kho\u1ea3ng QT, t\u0103ng ti\u1ec3u c\u1ea7u, vi\u00eam t\u0129nh m\u1ea1ch t\u1ea1i v\u1ecb tr\u00ed truy\u1ec1n, kh\u00f4 da, t\u0103ng LDH, gi\u1ea3m b\u1ea1ch c\u1ea7u, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, \u0111au ng\u1ef1c, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, nh\u00ecn \u0111\u00f4i, nh\u00ecn m\u1edd, t\u0103ng acid uric m\u00e1u, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, m\u1ea5t n\u01b0\u1edbc, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, k\u00e9o d\u00e0i th\u1eddi gian prothrombin, t\u0103ng INR, lo \u00e2u, t\u0103ng ho\u1ea1t \u0111\u1ed9ng t\u00e2m th\u1ea7n v\u1eadn \u0111\u1ed9ng, m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, \u0111au v\u00f9ng ch\u1eadu, \u0111au c\u00e1c chi, \u0111\u1ed5 m\u1ed3 h\u00f4i, gi\u00e3n m\u1ea1ch, rung nh\u0129, nh\u1ecbp tim nhanh, \u0111au th\u1eaft ng\u1ef1c.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Vi\u00eam g\u00e2n, r\u1ed1i lo\u1ea1n kh\u1ee9u gi\u00e1c ho\u1eb7c m\u1ea5t kh\u1ee9u gi\u00e1c, t\u0103ng BUN, \u00f9 tai, \u1ea3o gi\u00e1c, nh\u1ecbp nhanh th\u1ea5t, r\u1ed1i lo\u1ea1n ph\u1ed1i h\u1ee3p v\u1eadn \u0111\u1ed9ng, gi\u1ea3m c\u1ea3m gi\u00e1c, suy th\u1eadn, v\u00e0ng da, ph\u00f9, kh\u00f3 nu\u1ed1t, t\u0103ng huy\u1ebft \u00e1p, h\u1ea1 huy\u1ebft \u00e1p, co gi\u1eadt, suy gi\u1ea3m tr\u00ed nh\u1edb, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, r\u1ed1i lo\u1ea1n ch\u00fa \u00fd, gi\u1ea5c m\u01a1 b\u1ea5t th\u01b0\u1eddng, b\u1ec7nh l\u00fd th\u1ea7n kinh ngo\u1ea1i bi\u00ean, \u0111a d\u00e2y th\u1ea7n kinh, ng\u1ea5t, suy gi\u1ea3m th\u00ednh l\u1ef1c, \u0111i\u1ebfc, c\u1ea3m x\u00fac kh\u00f4ng \u1ed5n \u0111\u1ecbnh, tr\u1ea7m c\u1ea3m, m\u00ea s\u1ea3ng, vi\u00eam gan ch\u1ee7 y\u1ebfu do \u1ee9 m\u1eadt, vi\u00eam \u0111\u1ea1i tr\u00e0ng li\u00ean quan \u0111\u1ebfn kh\u00e1ng sinh, vi\u00eam \u0111\u1ea1i tr\u00e0ng gi\u1ea3 m\u1ea1c, chu\u1ed9t r\u00fat, co gi\u1eadt c\u01a1, y\u1ebfu c\u01a1, t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn, t\u0103ng creatinin, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, s\u1ed1c ph\u1ea3n v\u1ec7, ph\u00f9 m\u1ea1ch, ph\u00f9 thanh qu\u1ea3n.<\/p>\n<p>R\u1ea5t hi\u1ebfm g\u1eb7p: \u0110\u1ee9t g\u00e2n, h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, h\u00f4n m\u00ea do h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, vi\u00eam kh\u1edbp, c\u1ee9ng c\u01a1, t\u0103ng c\u1ea3m gi\u00e1c, m\u1ea5t th\u1ecb l\u1ef1c tho\u00e1ng qua, lo\u1ea1n nh\u1ecbp tim, xo\u1eafn \u0111\u1ec9nh, ng\u1eebng tim, vi\u00eam m\u1ea1ch, h\u1ed9i ch\u1ee9ng ti\u1ebft ADH kh\u00f4ng th\u00edch h\u1ee3p (SIADH), gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u, gi\u1ea3m ch\u1ec9 s\u1ed1 INR, t\u0103ng n\u1ed3ng \u0111\u1ed9 prothrombin, b\u1ea5t th\u01b0\u1eddng n\u1ed3ng \u0111\u1ed9 prothrombin\/INR, m\u1ea5t nh\u00e2n c\u00e1ch, r\u1ed1i lo\u1ea1n lo\u1ea1n th\u1ea7n, \u00fd ngh\u0129 ho\u1eb7c h\u00e0nh vi t\u1ef1 s\u00e1t, vi\u00eam gan t\u1ed1i c\u1ea5p g\u00e2y suy gan \u0111e d\u1ecda t\u00ednh m\u1ea1ng (c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong), l\u00e0m n\u1eb7ng th\u00eam tri\u1ec7u ch\u1ee9ng b\u1ec7nh nh\u01b0\u1ee3c c\u01a1.<\/p>\n<p>Ch\u01b0a r\u00f5 t\u1ea7n su\u1ea5t: Ti\u00eau c\u01a1 v\u00e2n, ph\u00e1t ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p t\u00ednh (AGEP).<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT: Khi d\u00f9ng c\u00f9ng moxifloxacin, c\u00e1c thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t, \u0111\u1eb7c bi\u1ec7t l\u00e0 xo\u1eafn \u0111\u1ec9nh. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p v\u1edbi disopyramid, quinidin, hydroquinidin, amiodaron, ibutilid, dofetilid, sotalol, pimozid, haloperidol, phenothiazin, sertindol, sultoprid, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng, astemizol, terfenadin, mizolastin, saquinavir, erythromycin ti\u00eam t\u0129nh m\u1ea1ch, sparfloxacin, pentamidin, cisaprid, halofactrin, bepridil, vincamin v\u00e0 diphemanil.<\/p>\n<p>Thu\u1ed1c g\u00e2y h\u1ea1 kali m\u00e1u: C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi corticosteroid, amphotericin B, thu\u1ed1c nhu\u1eadn tr\u00e0ng, thu\u1ed1c th\u1ee5t th\u00e1o li\u1ec1u cao, thu\u1ed1c l\u1ee3i ti\u1ec3u quai v\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u thiazid.<\/p>\n<p>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim: L\u01b0u \u00fd khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi nh\u1eefng thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ch\u1eadm nh\u1ecbp tim \u0111\u00e1ng k\u1ec3 tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p>Digoxin: Moxifloxacin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kho\u1ea3ng 30% n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a digoxin, trong khi AUC v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3. Kh\u00f4ng c\u1ea7n \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p th\u1eadn tr\u1ecdng \u0111\u1eb7c bi\u1ec7t khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Glibenclamid: Khi d\u00f9ng \u0111\u1ed3ng th\u1eddi, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh glibenclamid trong huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m kho\u1ea3ng 21%. Nguy c\u01a1 t\u0103ng glucose m\u00e1u nh\u1eb9, tho\u00e1ng qua c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u1eb7t ra v\u1ec1 m\u1eb7t l\u00fd thuy\u1ebft, tuy nhi\u00ean ch\u01b0a ghi nh\u1eadn bi\u1ebfn \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 v\u1ec1 glucose m\u00e1u v\u00e0 insulin tr\u00ean th\u1ef1c t\u1ebf.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng: Moxifloxacin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh ch\u1ed1ng \u0111\u00f4ng khi s\u1eed d\u1ee5ng c\u00f9ng nh\u00f3m thu\u1ed1c n\u00e0y. N\u00ean ki\u1ec3m tra INR th\u01b0\u1eddng xuy\u00ean v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng khi c\u1ea7n.<\/p>\n<p>C\u00e1c thu\u1ed1c kh\u00e1c: Ch\u01b0a ph\u00e1t hi\u1ec7n t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng gi\u1eefa moxifloxacin v\u1edbi itraconazol, cyclosporin, theophylin, morphin ti\u00eam t\u0129nh m\u1ea1ch, calci, thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng, probenecid v\u00e0 ranitidin. Kh\u1ea3 n\u0103ng x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c chuy\u1ec3n h\u00f3a qua h\u1ec7 enzyme cytochrome P450 t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng moxifloxacin c\u00f9ng th\u1ee9c \u0103n, k\u1ec3 c\u1ea3 s\u1eefa v\u00e0 c\u00e1c ch\u1ebf ph\u1ea9m t\u1eeb s\u1eefa, kh\u00f4ng g\u00e2y t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng.<\/p>\n<p>Kh\u00f4ng ph\u1ed1i h\u1ee3p dung d\u1ecbch ti\u00eam truy\u1ec1n Ratida v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o kh\u00e1c ngo\u00e0i nh\u1eefng dung d\u1ecbch \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 t\u01b0\u01a1ng th\u00edch.<\/p>\n<ul>\n<li>Dung d\u1ecbch kh\u00f4ng t\u01b0\u01a1ng th\u00edch: Natri bicarbonat 8,4%, natri bicarbonat 4,2%, natri clorid 20% v\u00e0 natri clorid 10%.<\/li>\n<li>Dung d\u1ecbch t\u01b0\u01a1ng th\u00edch: Glucose 40%, glucose 10%, glucose 5%, natri clorid 1 M, natri clorid 0,9%, n\u01b0\u1edbc c\u1ea5t pha ti\u00eam, xylitol 20%, dung d\u1ecbch Hartmann, Ringer lactat v\u00e0 Ringer.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Do kh\u00e1ng sinh nh\u00f3m fluoroquinolon \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua th\u1ef1c nghi\u1ec7m c\u00f3 kh\u1ea3 n\u0103ng h\u1ee7y ho\u1ea1i s\u1ee5n ch\u1ecbu s\u1ee9c n\u1eb7ng tr\u00ean c\u01a1 th\u1ec3 \u0111\u1ed9ng v\u1eadt non v\u00e0 t\u1eebng ghi nh\u1eadn t\u00ecnh tr\u1ea1ng t\u1ed5n th\u01b0\u01a1ng kh\u1edbp thu\u1eadn ngh\u1ecbch \u1edf tr\u1ebb em \u0111i\u1ec1u tr\u1ecb b\u1eb1ng nh\u00f3m thu\u1ed1c n\u00e0y, vi\u1ec7c ch\u1ec9 \u0111\u1ecbnh moxifloxacin cho ph\u1ee5 n\u1eef mang thai l\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p. Th\u00eam v\u00e0o \u0111\u00f3, t\u00ednh an to\u00e0n c\u1ee7a ho\u1ea1t ch\u1ea5t tr\u00ean thai ph\u1ee5 hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u x\u00e1c th\u1ef1c, m\u1ee9c \u0111\u1ed9 r\u1ee7i ro cho ng\u01b0\u1eddi ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5, v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ed9ng v\u1eadt c\u0169ng \u0111\u00e3 ch\u1ec9 ra \u0111\u1ed9c t\u00ednh \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<p>V\u00ec c\u00e1c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt non \u0111\u00e3 ch\u1ee9ng minh nh\u00f3m fluoroquinolon ti\u1ec1m \u1ea9n nguy c\u01a1 ph\u00e1 h\u1ee7y s\u1ee5n ch\u1ecbu l\u1ef1c, v\u00e0 vi\u1ec7c ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n tr\u00ean ng\u01b0\u1eddi (d\u00f9 d\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng ghi nh\u1eadn moxifloxacin b\u00e0i ti\u1ebft m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf v\u00e0o s\u1eefa m\u1eb9 v\u00e0 hi\u1ec7n ch\u01b0a c\u00f3 th\u00f4ng tin ch\u00ednh th\u1ee9c v\u1ec1 ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa), vi\u1ec7c duy tr\u00ec cho con b\u00fa trong qu\u00e1 tr\u00ecnh m\u1eb9 d\u00f9ng thu\u1ed1c moxifloxacin l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>D\u00f9 ch\u01b0a ghi nh\u1eadn nghi\u00ean c\u1ee9u n\u00e0o kh\u1ea3o s\u00e1t tr\u1ef1c ti\u1ebfp t\u00e1c \u0111\u1ed9ng c\u1ee7a moxifloxacin tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, c\u00e1c thu\u1ed1c thu\u1ed9c nh\u00f3m fluoroquinolon n\u00f3i chung v\u00e0 moxifloxacin n\u00f3i ri\u00eang v\u1eabn ti\u1ec1m \u1ea9n kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m s\u00fat n\u0103ng l\u1ef1c th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y. Nguy\u00ean nh\u00e2n b\u1eaft ngu\u1ed3n t\u1eeb c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 ch\u00f3ng m\u1eb7t, m\u1ea5t th\u1ecb l\u1ef1c c\u1ea5p t\u00ednh hay t\u1ea1m th\u1eddi, ho\u1eb7c hi\u1ec7n t\u01b0\u1ee3ng ng\u1ea5t do m\u1ea5t \u00fd th\u1ee9c tho\u00e1ng qua. Do \u0111\u00f3, ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o c\u1ea7n quan s\u00e1t k\u1ef9 c\u00e1ch c\u01a1 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi moxifloxacin tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u khi\u1ec3n xe c\u1ed9 hay m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Kh\u00f4ng c\u00f3 ph\u00e1c \u0111\u1ed3 gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u khi v\u00f4 t\u00ecnh d\u00f9ng qu\u00e1 li\u1ec1u quy \u0111\u1ecbnh, ch\u1ee7 y\u1ebfu ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ebft h\u1ee3p theo d\u00f5i ECG li\u00ean t\u1ee5c nh\u1eb1m ph\u00e1t hi\u1ec7n nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi than ho\u1ea1t khi b\u1ec7nh nh\u00e2n d\u00f9ng 400mg moxifloxacin s\u1ebd l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c xu\u1ed1ng m\u1ee9c tr\u00ean 80% (\u0111\u1ed1i v\u1edbi \u0111\u01b0\u1eddng u\u1ed1ng) v\u00e0 20% (\u0111\u1ed1i v\u1edbi \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch). Trong c\u00e1c ca qu\u00e1 li\u1ec1u \u0111\u01b0\u1eddng u\u1ed1ng, vi\u1ec7c \u0111\u01b0a than ho\u1ea1t v\u00e0o s\u1edbm trong pha h\u1ea5p thu c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1n ch\u1ebf t\u1ed1i \u0111a s\u1ef1 t\u0103ng v\u1ecdt l\u01b0\u1ee3ng moxifloxacin \u0111i v\u00e0o h\u1ec7 tu\u1ea7n ho\u00e0n.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Ratida 400mg\/250ml \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Ratida 400mg\/250ml trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Ratida 400mg\/250ml khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Ratida 400mg\/250ml gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Ratida 400mg\/250ml hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Ratida 400mg\/250ml c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Ratida 400mg\/250ml t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Ratida 400mg\/250ml nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/moxifloxacin-400mg-250ml-imexpharm\/\">Moxifloxacin 400mg\/250ml Imexpharm<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Moxifloxacin 400mg\/250ml, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Imexpharm, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ti\u00eam truy\u1ec1n trong tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/mxn-400mg-250ml\/\">MXN 400mg\/250ml <\/a>c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Moxifloxacin 400mg\/250ml, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi PT Ferron Par Pharmaceuticals, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ti\u00eam truy\u1ec1n trong tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Tulkens PM, Arvis P, Kruesmann F (2012). Moxifloxacin safety: an analysis of 14 years of clinical data. Drugs R D. Truy c\u1eadp ng\u00e0y 13 th\u00e1ng 11 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3585838\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3585838\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Ratida 400mg\/250ml ch\u1ee9a ho\u1ea1t ch\u1ea5t moxifloxacin, thu\u1ed9c nh\u00f3m kh\u00e1ng sinh fluoroquinolon, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m.<\/p>\n","protected":false},"author":1,"featured_media":164931,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-164930","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/164930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=164930"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/164931"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=164930"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=164930"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=164930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}