{"id":164913,"date":"2026-11-13T23:43:38","date_gmt":"2026-11-13T16:43:38","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=164913"},"modified":"2026-11-13T23:44:43","modified_gmt":"2026-11-13T16:44:43","slug":"thuoc-ratida-400mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-ratida-400mg\/","title":{"rendered":"Ratida 400mg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Ratida 400mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi KRKA, D.D., . Novo Mesto c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-22635-20<\/b><\/p>\n<h2>Ratida 400mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i vi\u00ean <b>Ratida 400mg<\/b> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Moxifloxacin (d\u01b0\u1edbi d\u1ea1ng Moxifloxacin hydrochlorid): 400mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-22635-20<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 5 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Slovenia<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Ratida 400mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Moxifloxacin k\u00ecm h\u00e3m ho\u1ea1t t\u00ednh c\u1ee7a c\u1ea3 DNA gyrase l\u1eabn topoisomerase IV (thu\u1ed9c nh\u00f3m topoisomerase lo\u1ea1i II), qua \u0111\u00f3 ng\u0103n ch\u1eb7n c\u00e1c enzym thi\u1ebft y\u1ebfu ph\u1ee5c v\u1ee5 qu\u00e1 tr\u00ecnh sao ch\u00e9p, phi\u00ean m\u00e3 v\u00e0 s\u1eeda ch\u1eefa v\u1eadt ch\u1ea5t di truy\u1ec1n DNA \u1edf vi khu\u1ea9n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Moxifloxacin qua \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 kh\u1ea3 n\u0103ng \u0111i v\u00e0o tu\u1ea7n ho\u00e0n g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n, v\u1edbi t\u1ef7 l\u1ec7 sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 91%. \u0110\u1eb7c t\u00ednh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c t\u01b0\u01a1ng \u0111\u1ed1i \u1ed5n \u0111\u1ecbnh trong kho\u1ea3ng li\u1ec1u 50-800 mg khi d\u00f9ng m\u1ed9t l\u1ea7n v\u00e0 \u1edf m\u1ee9c 600 mg\/ng\u00e0y trong 10 ng\u00e0y. Sau khi u\u1ed1ng 400mg, n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng cao nh\u1ea5t kho\u1ea3ng 3,1 mg\/L, th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n sau 30 ph\u00fat \u0111\u1ebfn 4 gi\u1edd. V\u1edbi ch\u1ebf \u0111\u1ed9 d\u00f9ng 400mg m\u1ed7i ng\u00e0y, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y khi thu\u1ed1c \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u1ea7n l\u01b0\u1ee3t ghi nh\u1eadn \u1edf m\u1ee9c 3,2 mg\/L v\u00e0 0,6 mg\/L. M\u1ee9c ph\u01a1i nhi\u1ec5m thu\u1ed1c trong giai \u0111o\u1ea1n \u1ed5n \u0111\u1ecbnh cao h\u01a1n kho\u1ea3ng 30% so v\u1edbi l\u1ea7n d\u00f9ng \u0111\u1ea7u ti\u00ean.<\/p>\n<p>Albumin huy\u1ebft t\u01b0\u01a1ng l\u00e0 protein ch\u1ee7 y\u1ebfu tham gia li\u00ean k\u1ebft v\u1edbi moxifloxacin, v\u1edbi t\u1ef7 l\u1ec7 g\u1eafn k\u1ebft \u0111\u01b0\u1ee3c ghi nh\u1eadn kho\u1ea3ng 40-42% v\u00e0 kh\u00f4ng thay \u0111\u1ed5i theo n\u1ed3ng \u0111\u1ed9 thu\u1ed1c (theo c\u00e1c nghi\u00ean c\u1ee9u in vitro v\u00e0 ex vivo). Thu\u1ed1c c\u00f3 th\u1ec3 nhanh ch\u00f3ng lan \u0111\u1ebfn c\u00e1c khoang ngo\u1ea1i b\u00e0o, v\u1edbi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (Vss) kho\u1ea3ng 2 L\/kg. Sau khi s\u1eed d\u1ee5ng li\u1ec1u u\u1ed1ng 400mg, gi\u00e1 tr\u1ecb AUC \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 35 mg\u00b7gi\u1edd\/L. C\u00e1c ph\u00e9p \u0111o c\u0169ng cho th\u1ea5y n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh c\u1ee7a moxifloxacin t\u1ea1i nh\u1eefng v\u1ecb tr\u00ed ph\u00e2n b\u1ed1 kh\u00e1c nhau sau m\u1ed9t l\u1ea7n u\u1ed1ng 400mg.<\/p>\n<p>Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u1ee7a moxifloxacin ch\u1ee7 y\u1ebfu di\u1ec5n ra theo con \u0111\u01b0\u1eddng pha II, t\u1ea1o ra hai d\u1eabn xu\u1ea5t l\u00e0 M1 (sulpho) v\u00e0 M2 (glucuronid). \u0110\u00e2y l\u00e0 nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f2n kh\u1ea3 n\u0103ng di\u1ec7t khu\u1ea9n. V\u1ec1 th\u1ea3i tr\u1eeb, kho\u1ea3ng 60% l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua \u0111\u01b0\u1eddng m\u1eadt v\u00e0 ph\u00e2n, ph\u1ea7n c\u00f2n l\u1ea1i kho\u1ea3ng 40% \u0111\u01b0\u1ee3c b\u00e0i xu\u1ea5t qua th\u1eadn; thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i ra \u1edf c\u1ea3 d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a v\u00e0 d\u1ea1ng \u0111\u00e3 chuy\u1ec3n h\u00f3a. Moxifloxacin kh\u00f4ng ghi nh\u1eadn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a oxy h\u00f3a. \u0110\u1ed3ng th\u1eddi, k\u1ebft qu\u1ea3 t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean l\u00e2m s\u00e0ng pha I v\u00e0 th\u1eed nghi\u1ec7m in vitro cho th\u1ea5y thu\u1ed1c kh\u00f4ng g\u00e2y t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u1edbi c\u00e1c ho\u1ea1t ch\u1ea5t c\u00f3 qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a pha I th\u00f4ng qua h\u1ec7 enzym cytochrom P450.<\/p>\n<p>Kho\u1ea3ng 12 gi\u1edd l\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a moxifloxacin trong huy\u1ebft t\u01b0\u01a1ng. \u1ede li\u1ec1u 400mg, \u0111\u1ed9 thanh th\u1ea3i to\u00e0n ph\u1ea7n \u0111\u1ea1t 179-246 ml\/ph\u00fat. Khi s\u1eed d\u1ee5ng thu\u1ed1c b\u1eb1ng \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch, l\u01b0\u1ee3ng moxifloxacin \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n l\u1ea7n l\u01b0\u1ee3t chi\u1ebfm kho\u1ea3ng 22% v\u00e0 26% li\u1ec1u d\u00f9ng. T\u1ed5ng l\u01b0\u1ee3ng moxifloxacin v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng kho\u1ea3ng 98% li\u1ec1u \u0111\u00e3 truy\u1ec1n<\/p>\n<p>\u0110\u1ed9 thanh th\u1ea3i qua th\u1eadn n\u1eb1m trong kho\u1ea3ng 24-53 ml\/ph\u00fat, cho th\u1ea5y m\u1ed9t ph\u1ea7n moxifloxacin \u0111\u01b0\u1ee3c t\u00e1i h\u1ea5p thu t\u1ea1i c\u00e1c \u1ed1ng th\u1eadn. Ranitidin v\u00e0 probenecid khi d\u00f9ng ph\u1ed1i h\u1ee3p kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ed9 thanh th\u1ea3i qua th\u1eadn c\u1ee7a moxifloxacin \u1edf d\u1ea1ng ch\u01b0a bi\u1ebfn \u0111\u1ed5i.<\/p>\n<h2>Thu\u1ed1c Ratida 400mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Ratida d\u1ea1ng u\u1ed1ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n \u1edf ng\u01b0\u1eddi l\u1edbn t\u1eeb 18 tu\u1ed5i, v\u1edbi t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh l\u00e0 c\u00e1c ch\u1ee7ng vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi moxifloxacin. Kh\u00e1ng sinh n\u00e0y kh\u00f4ng ph\u1ea3i l\u1ef1a ch\u1ecdn \u01b0u ti\u00ean trong m\u1ecdi tr\u01b0\u1eddng h\u1ee3p m\u00e0 ch\u1ec9 \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng th\u1ec3 \u00e1p d\u1ee5ng ngay t\u1eeb \u0111\u1ea7u ho\u1eb7c \u0111\u00e3 th\u1ea5t b\u1ea1i. Nh\u1eefng b\u1ec7nh l\u00fd c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng thu\u1ed1c bao g\u1ed3m:<\/p>\n<ul>\n<li>Vi\u00eam xoang c\u1ea5p do vi khu\u1ea9n: Ch\u1ec9 \u00e1p d\u1ee5ng khi \u0111\u00e3 c\u00f3 k\u1ebft qu\u1ea3 ch\u1ea9n \u0111o\u00e1n x\u00e1c \u0111\u1ecbnh b\u1ec7nh. Vi\u1ec7c d\u00f9ng moxifloxacin c\u1ea7n \u0111\u01b0\u1ee3c h\u1ea1n ch\u1ebf do fluoroquinolon c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng (xem m\u1ee5c C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c). B\u00ean c\u1ea1nh \u0111\u00f3, b\u1ec7nh c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 thuy\u00ean gi\u1ea3m \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ec7nh n\u00ean ch\u1ec9 l\u1ef1a ch\u1ecdn kh\u00e1ng sinh n\u00e0y khi kh\u00f4ng c\u00f2n bi\u1ec7n ph\u00e1p thay th\u1ebf ph\u00f9 h\u1ee3p.<\/li>\n<li>Vi\u00eam ph\u1ed5i m\u1eafc ph\u1ea3i c\u1ed9ng \u0111\u1ed3ng: D\u00f9ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng thu\u1ed9c nh\u00f3m b\u1ec7nh n\u1eb7ng.<\/li>\n<li>\u0110\u1ee3t nhi\u1ec5m khu\u1ea9n c\u1ea5p t\u00ednh tr\u00ean n\u1ec1n vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh: Ch\u1ec9 c\u00e2n nh\u1eafc moxifloxacin n\u1ebfu nh\u1eefng kh\u00e1ng sinh kh\u00e1c kh\u00f4ng \u0111\u00e1p \u1ee9ng y\u00eau c\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c kh\u00f4ng th\u1ec3 s\u1eed d\u1ee5ng. \u0110i\u1ec1u n\u00e0y xu\u1ea5t ph\u00e1t t\u1eeb nguy c\u01a1 x\u1ea3y ra ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng c\u1ee7a nh\u00f3m fluoroquinolon, trong khi t\u00ecnh tr\u1ea1ng nhi\u1ec5m khu\u1ea9n \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 t\u1ef1 c\u1ea3i thi\u1ec7n m\u00e0 kh\u00f4ng c\u1ea7n can thi\u1ec7p b\u1eb1ng kh\u00e1ng sinh n\u00e0y.<\/li>\n<li>Vi\u00eam v\u00f9ng ch\u1eadu m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh: Ch\u1ec9 \u0111\u1ecbnh bao g\u1ed3m c\u00e1c t\u00ecnh tr\u1ea1ng nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng sinh d\u1ee5c tr\u00ean \u1edf n\u1eef gi\u1edbi, \u0111i\u1ec3n h\u00ecnh l\u00e0 vi\u00eam v\u00f2i tr\u1ee9ng v\u00e0 vi\u00eam n\u1ed9i m\u1ea1c t\u1eed cung, v\u1edbi \u0111i\u1ec1u ki\u1ec7n ch\u01b0a h\u00ecnh th\u00e0nh \u00e1p xe t\u1ea1i v\u00f2i tr\u1ee9ng ho\u1eb7c v\u00f9ng ch\u1eadu. Trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y, kh\u00f4ng n\u00ean d\u00f9ng moxifloxacin l\u00e0m kh\u00e1ng sinh duy nh\u1ea5t m\u00e0 c\u1ea7n k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c kh\u00e1ng khu\u1ea9n th\u00edch h\u1ee3p kh\u00e1c (v\u00ed d\u1ee5 cephalosporin), b\u1edfi Neisseria gonorrhoeae c\u00f3 xu h\u01b0\u1edbng gia t\u0103ng kh\u1ea3 n\u0103ng kh\u00e1ng moxifloxacin. Ngo\u1ea1i l\u1ec7 l\u00e0 khi \u0111\u00e3 x\u00e1c \u0111\u1ecbnh kh\u00f4ng c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a ch\u1ee7ng vi khu\u1ea9n kh\u00e1ng thu\u1ed1c n\u00e0y.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u kh\u00f4ng ph\u1ee9c t\u1ea1p: Kh\u00f4ng l\u1ef1a ch\u1ecdn moxifloxacin th\u01b0\u1eddng quy do b\u1ec7nh c\u00f3 th\u1ec3 t\u1ef1 kh\u1ecfi \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, \u0111\u1ed3ng th\u1eddi fluoroquinolon c\u00f3 nguy c\u01a1 g\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng. Ch\u1ec9 s\u1eed d\u1ee5ng khi nh\u1eefng ph\u01b0\u01a1ng \u00e1n \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng c\u00f2n ph\u00f9 h\u1ee3p.<\/li>\n<\/ul>\n<p>L\u01b0u \u00fd: Ch\u1ebf ph\u1ea9m Ratida \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ti\u1ebfp t\u1ee5c li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e3 c\u00f3 \u0111\u00e1p \u1ee9ng t\u00edch c\u1ef1c sau khi kh\u1edfi \u0111\u1ea7u b\u1eb1ng moxifloxacin ti\u00eam t\u0129nh m\u1ea1ch \u0111\u1ed1i v\u1edbi vi\u00eam ph\u1ed5i m\u1eafc ph\u1ea3i c\u1ed9ng \u0111\u1ed3ng ho\u1eb7c nhi\u1ec5m khu\u1ea9n da v\u00e0 c\u1ea5u tr\u00fac da ph\u1ee9c t\u1ea1p. Kh\u00f4ng s\u1eed d\u1ee5ng ch\u1ebf ph\u1ea9m \u0111\u01b0\u1eddng u\u1ed1ng n\u00e0y \u0111\u1ec3 kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb vi\u00eam ph\u1ed5i m\u1eafc ph\u1ea3i c\u1ed9ng \u0111\u1ed3ng th\u1ec3 n\u1eb7ng ho\u1eb7c nhi\u1ec5m khu\u1ea9n da v\u00e0 c\u1ea5u tr\u00fac da.<\/p>\n<figure id=\"attachment_164941\" aria-describedby=\"caption-attachment-164941\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-164941\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg.jpg\" alt=\"Ratida 400mg\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Ratida-400mg-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-164941\" class=\"wp-caption-text\">Thu\u1ed1c Ratida 400mg \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n h\u00f4 h\u1ea5p, da v\u00e0 \u1ed5 b\u1ee5ng<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>1 vi\u00ean\/ng\u00e0y<\/p>\n<p>Suy th\u1eadn, suy gan: D\u00f9 ch\u1ee9c n\u0103ng th\u1eadn suy gi\u1ea3m \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 hay n\u1eb7ng, ng\u01b0\u1eddi b\u1ec7nh v\u1eabn c\u00f3 th\u1ec3 duy tr\u00ec li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng, k\u1ec3 c\u1ea3 khi \u0111ang l\u1ecdc m\u00e1u ho\u1eb7c th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c. Tuy nhi\u00ean, d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u1edf ng\u01b0\u1eddi b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng gan hi\u1ec7n c\u00f2n h\u1ea1n ch\u1ebf, ch\u01b0a \u0111\u1ee7 c\u01a1 s\u1edf \u0111\u1ec3 \u0111\u01b0a ra h\u01b0\u1edbng d\u1eabn c\u1ee5 th\u1ec3.<\/p>\n<p>Ng\u01b0\u1eddi nh\u1eb9 c\u00e2n, ng\u01b0\u1eddi cao tu\u1ed5i: Th\u1ec3 tr\u1ea1ng nh\u1eb9 c\u00e2n ho\u1eb7c tu\u1ed5i cao kh\u00f4ng ph\u1ea3i l\u00e0 y\u1ebfu t\u1ed1 \u0111\u00f2i h\u1ecfi ph\u1ea3i thay \u0111\u1ed5i li\u1ec1u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean: Thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi d\u01b0\u1edbi 18 tu\u1ed5i v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u1edf nh\u00f3m tu\u1ed5i n\u00e0y. Nguy\u00ean nh\u00e2n l\u00e0 do hi\u1ec7u qu\u1ea3 c\u0169ng nh\u01b0 t\u00ednh an to\u00e0n khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p><strong>Vi\u00ean n\u00e9n Ratida 400mg<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Ratida 400mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi moxifloxacin ho\u1eb7c t\u00e1 d\u01b0\u1ee3c c\u00f3 trong <b>vi\u00ean n\u00e9n Ratida 400mg<\/b> ho\u1eb7c c\u00e1c kh\u00e1ng sinh thu\u1ed9c nh\u00f3m quinolon<\/p>\n<p>C\u00e1c nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng bao g\u1ed3m tr\u1ebb nh\u1ecf v\u00e0 thanh thi\u1ebfu ni\u00ean thu\u1ed9c \u0111\u1ed9 tu\u1ed5i d\u01b0\u1edbi 18, c\u00f9ng v\u1edbi ph\u1ee5 n\u1eef \u0111ang mang b\u1ea7u ho\u1eb7c \u0111ang cho tr\u1ebb b\u00fa s\u1eefa m\u1eb9.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh t\u1eebng c\u00f3 ti\u1ec1n s\u1eed m\u1eafc c\u00e1c t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c b\u1ec7nh l\u00fd \u1edf g\u00e2n do s\u1eed d\u1ee5ng kh\u00e1ng sinh nh\u00f3m quinolon.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p mang y\u1ebfu t\u1ed1 nguy c\u01a1 l\u00e0m kho\u1ea3ng QT k\u00e9o d\u00e0i do b\u1ea5t th\u01b0\u1eddng \u0111i\u1ec7n gi\u1ea3i ho\u1eb7c b\u1ec7nh l\u00fd tim m\u1ea1ch, k\u1ec3 c\u1ea3 ng\u01b0\u1eddi b\u1ecb QT k\u00e9o d\u00e0i di truy\u1ec1n (b\u1ea9m sinh), h\u1ea1 kali huy\u1ebft ch\u01b0a \u0111\u01b0\u1ee3c b\u00f9 \u0111\u1eafp, suy tim c\u00f3 bi\u1ec3u hi\u1ec7n b\u1ec7nh l\u00fd, nh\u1ecbp ch\u1eadm \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng hay ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed b\u1ecb lo\u1ea1n nh\u1ecbp tim.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p hi\u1ec7n \u0111ang s\u1eed d\u1ee5ng chung v\u1edbi nh\u00f3m thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng k\u00e9o d\u00e0i kho\u1ea3ng QT khi \u0111o \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 ch\u1ec9 s\u1ed1 transaminase v\u01b0\u1ee3t m\u1ee9c 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a tr\u1ecb s\u1ed1 b\u00ecnh th\u01b0\u1eddng (ULN) ho\u1eb7c \u0111ang b\u1ecb suy y\u1ebfu ch\u1ee9c n\u0103ng gan.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>C\u1ea7n c\u00e2n nh\u1eafc k\u1ef9 l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 tr\u01b0\u1edbc khi l\u1ef1a ch\u1ecdn moxifloxacin, \u0111\u1eb7c bi\u1ec7t khi v\u1eabn c\u00f2n c\u00e1c kh\u00e1ng sinh thay th\u1ebf. Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng \u1edf ng\u01b0\u1eddi t\u1eebng g\u1eb7p ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng v\u1edbi quinolon ho\u1eb7c fluoroquinolon, tr\u1eeb tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng \u00e1n \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p kh\u00e1c.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed gia \u0111\u00ecnh m\u1eafc ph\u00ecnh \u0111\u1ed9ng m\u1ea1ch, b\u00f3c t\u00e1ch \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ho\u1eb7c b\u1ec7nh van tim; ng\u01b0\u1eddi m\u1eafc b\u1ec7nh m\u00f4 li\u00ean k\u1ebft, t\u0103ng huy\u1ebft \u00e1p, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p ho\u1eb7c c\u00e1c b\u1ec7nh l\u00fd m\u1ea1ch m\u00e1u c\u00f3 li\u00ean quan. Nguy c\u01a1 c\u1ea7n \u0111\u01b0\u1ee3c l\u01b0u \u00fd h\u01a1n \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng corticosteroid to\u00e0n th\u00e2n.<\/p>\n<p>Khi truy\u1ec1n t\u0129nh m\u1ea1ch, m\u1ed7i li\u1ec1u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 400mg v\u00e0 th\u1eddi gian truy\u1ec1n ph\u1ea3i k\u00e9o d\u00e0i \u00edt nh\u1ea5t 60 ph\u00fat. C\u1ea7n th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi c\u00f3 b\u1ec7nh l\u00fd tim m\u1ea1ch, nh\u1ecbp tim ch\u1eadm, h\u1ea1 kali m\u00e1u ho\u1eb7c \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed co gi\u1eadt, r\u1ed1i lo\u1ea1n th\u1ea7n kinh trung \u01b0\u01a1ng, b\u1ec7nh t\u00e2m th\u1ea7n ho\u1eb7c nh\u01b0\u1ee3c c\u01a1 c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 c\u1ea9n th\u1eadn tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Theo d\u00f5i ch\u1ee9c n\u0103ng gan n\u1ebfu xu\u1ea5t hi\u1ec7n bi\u1ec3u hi\u1ec7n nghi ng\u1edd t\u1ed5n th\u01b0\u01a1ng gan, \u0111\u1eb7c bi\u1ec7t khi c\u00f3 v\u00e0ng da, n\u01b0\u1edbc ti\u1ec3u s\u1eabm m\u00e0u, suy nh\u01b0\u1ee3c t\u0103ng d\u1ea7n ho\u1eb7c d\u1ea5u hi\u1ec7u xu\u1ea5t huy\u1ebft b\u1ea5t th\u01b0\u1eddng.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u1ea7n duy tr\u00ec \u0111\u1ee7 l\u01b0\u1ee3ng d\u1ecbch \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3 nh\u1eb1m h\u1ea1n ch\u1ebf nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng th\u1eadn do m\u1ea5t n\u01b0\u1edbc.<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u1ea7n theo d\u00f5i \u0111\u01b0\u1eddng huy\u1ebft th\u01b0\u1eddng xuy\u00ean, nh\u1ea5t l\u00e0 khi \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p v\u1edbi insulin ho\u1eb7c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u01b0\u1eddng u\u1ed1ng. Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi thi\u1ebfu h\u1ee5t glucose-6-phosphat dehydrogenase (G6PD) do nguy c\u01a1 tan m\u00e1u.<\/p>\n<p>N\u00ean h\u1ea1n ch\u1ebf ti\u1ebfp x\u00fac v\u1edbi \u00e1nh n\u1eafng m\u1ea1nh v\u00e0 tia UV trong th\u1eddi gian d\u00f9ng thu\u1ed1c. N\u1ebfu xu\u1ea5t hi\u1ec7n b\u1ea5t th\u01b0\u1eddng v\u1ec1 th\u1ecb gi\u00e1c, c\u1ea7n th\u0103m kh\u00e1m chuy\u00ean khoa m\u1eaft.<\/p>\n<p>Ng\u1eebng thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 l\u1ea1i ph\u01b0\u01a1ng \u00e1n \u0111i\u1ec1u tr\u1ecb khi xu\u1ea5t hi\u1ec7n c\u00e1c bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng nghi\u00eam tr\u1ecdng. Tr\u01b0\u1eddng h\u1ee3p \u0111au ng\u1ef1c, b\u1ee5ng ho\u1eb7c l\u01b0ng \u0111\u1ed9t ng\u1ed9t, kh\u00f3 th\u1edf c\u1ea5p t\u00ednh, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c m\u1edbi xu\u1ea5t hi\u1ec7n ho\u1eb7c ph\u00f9 ti\u1ebfn tri\u1ec3n c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u01b0a \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf ngay.<\/p>\n<p>Dung d\u1ecbch moxifloxacin ch\u1ec9 d\u00f9ng \u0111\u1ec3 truy\u1ec1n t\u0129nh m\u1ea1ch, kh\u00f4ng \u0111\u01b0\u1ee3c truy\u1ec1n qua \u0111\u1ed9ng m\u1ea1ch.<\/p>\n<p>M\u1ed7i li\u1ec1u thu\u1ed1c ch\u1ee9a 885,52 mg natri, c\u1ea7n l\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi \u0111ang th\u1ef1c hi\u1ec7n ch\u1ebf \u0111\u1ed9 \u0103n h\u1ea1n ch\u1ebf mu\u1ed1i.<\/p>\n<p>Moxifloxacin c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a Mycobacterium spp., g\u00e2y \u00e2m t\u00ednh gi\u1ea3 khi nu\u00f4i c\u1ea5y vi khu\u1ea9n lao t\u1eeb b\u1ec7nh ph\u1ea9m.<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng moxifloxacin \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n do t\u1ee5 c\u1ea7u v\u00e0ng kh\u00e1ng methicillin (MRSA). Hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u0169ng ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c l\u1eadp \u0111\u1ed1i v\u1edbi b\u1ecfng n\u1eb7ng, vi\u00eam c\u00e2n m\u1ea1c v\u00e0 nhi\u1ec5m tr\u00f9ng b\u00e0n ch\u00e2n do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng k\u00e8m vi\u00eam x\u01b0\u01a1ng t\u1ee7y.<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng moxifloxacin cho tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean d\u01b0\u1edbi 18 tu\u1ed5i do nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee5n kh\u1edbp.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p (1\/100 \u2264 ADR &lt; 1\/10): \u0110au b\u1ee5ng, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, t\u0103ng transaminase, k\u00e9o d\u00e0i kho\u1ea3ng QT \u1edf ng\u01b0\u1eddi c\u00f3 kali m\u00e1u th\u1ea5p, b\u1ed9i nhi\u1ec5m Candida t\u1ea1i mi\u1ec7ng ho\u1eb7c \u00e2m \u0111\u1ea1o v\u00e0 c\u00e1c nhi\u1ec5m khu\u1ea9n do vi sinh v\u1eadt kh\u00e1ng thu\u1ed1c.<\/p>\n<p>\u00cdt g\u1eb7p (1\/1.000 \u2264 ADR &lt; 1\/100): T\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, thi\u1ebfu m\u00e1u, gi\u1ea3m ti\u1ec3u c\u1ea7u, t\u0103ng ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m b\u1ea1ch c\u1ea7u, thay \u0111\u1ed5i th\u1eddi gian prothrombin v\u00e0 INR, d\u1ecb \u1ee9ng, t\u0103ng lipid m\u00e1u, t\u0103ng ho\u1ea1t \u0111\u1ed9ng, lo \u00e2u, k\u00edch \u0111\u1ed9ng, l\u00fa l\u1eabn, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, m\u1ea5t ng\u1ee7, run, r\u1ed1i lo\u1ea1n c\u1ea3m gi\u00e1c, m\u1ea5t ph\u01b0\u01a1ng h\u01b0\u1edbng, ng\u1ee7 g\u00e0, ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd, thay \u0111\u1ed5i th\u1ecb l\u1ef1c, \u0111au th\u1eaft ng\u1ef1c, rung nh\u0129, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, nh\u1ecbp tim nhanh, k\u00e9o d\u00e0i QT, gi\u00e3n m\u1ea1ch, kh\u00f3 th\u1edf ho\u1eb7c bi\u1ec3u hi\u1ec7n hen suy\u1ec5n, ch\u00e1n \u0103n, gi\u1ea3m th\u00e8m \u0103n, vi\u00eam d\u1ea1 d\u00e0y, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, kh\u00f3 ti\u00eau, t\u0103ng amylase, t\u0103ng bilirubin, t\u0103ng LDL, t\u0103ng gamma-glutamyl transferase, t\u0103ng phosphatase ki\u1ec1m, suy gi\u1ea3m ch\u1ee9c n\u0103ng gan, ban \u0111\u1ecf, ng\u1ee9a, kh\u00f4 da, m\u00e0y \u0111ay, \u0111au kh\u1edbp, \u0111au c\u01a1, m\u1ea5t n\u01b0\u1edbc, \u0111au v\u00f9ng ch\u1eadu, \u0111au c\u00e1c chi, \u0111au ng\u1ef1c, \u0111au l\u01b0ng, suy nh\u01b0\u1ee3c, m\u1ec7t m\u1ecfi, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i.<\/p>\n<p>Hi\u1ebfm g\u1eb7p (1\/10.000 \u2264 ADR &lt; 1\/1.000): Ph\u00f9 d\u1ecb \u1ee9ng, ph\u00f9 m\u1ea1ch, ph\u1ea3n v\u1ec7 c\u00f3 nguy c\u01a1 \u0111e d\u1ecda t\u00ednh m\u1ea1ng, ph\u00f9 thanh qu\u1ea3n, t\u0103ng acid uric, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, tr\u1ea7m c\u1ea3m k\u00e8m \u00fd ngh\u0129 ho\u1eb7c h\u00e0nh vi t\u1ef1 s\u00e1t, \u1ea3o gi\u00e1c, m\u00ea s\u1ea3ng, thay \u0111\u1ed5i c\u1ea3m x\u00fac, gi\u1ea3m c\u1ea3m gi\u00e1c, m\u1ea5t kh\u1ee9u gi\u00e1c m\u1ed9t ph\u1ea7n ho\u1eb7c ho\u00e0n to\u00e0n, \u0111\u1ed9ng kinh c\u01a1n l\u1edbn, \u00e1c m\u1ed9ng, hoa m\u1eaft, suy gi\u1ea3m tr\u00ed nh\u1edb, kh\u00f3 t\u1eadp trung, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, b\u1ec7nh l\u00fd th\u1ea7n kinh ngo\u1ea1i bi\u00ean, \u0111a d\u00e2y th\u1ea7n kinh, \u00f9 tai, gi\u1ea3m th\u00ednh l\u1ef1c ho\u1eb7c \u0111i\u1ebfc c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c, ng\u1ea5t, nh\u1ecbp nhanh th\u1ea5t, h\u1ea1 huy\u1ebft \u00e1p, t\u0103ng huy\u1ebft \u00e1p, lo\u00e9t mi\u1ec7ng, kh\u00f3 nu\u1ed1t, vi\u00eam \u0111\u1ea1i tr\u00e0ng do kh\u00e1ng sinh (bao g\u1ed3m th\u1ec3 m\u00e0ng gi\u1ea3, \u0111\u00f4i khi g\u00e2y bi\u1ebfn ch\u1ee9ng nguy hi\u1ec3m t\u00ednh m\u1ea1ng), vi\u00eam gan \u1ee9 m\u1eadt, v\u00e0ng da, co th\u1eaft c\u01a1, y\u1ebfu c\u01a1, vi\u00eam g\u00e2n, t\u0103ng BUN v\u00e0 creatinin, suy th\u1eadn, ph\u00f9 n\u1ec1.<\/p>\n<p>R\u1ea5t hi\u1ebfm g\u1eb7p (ADR &lt; 1\/10.000): H\u1ed9i ch\u1ee9ng ti\u1ebft hormon ch\u1ed1ng b\u00e0i ni\u1ec7u kh\u00f4ng th\u00edch h\u1ee3p (SIADH), m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m INR, t\u0103ng prothrombin, h\u00f4n m\u00ea do h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, lo\u1ea1n th\u1ea7n c\u00f3 nguy c\u01a1 t\u1ef1 g\u00e2y t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c t\u1ef1 s\u00e1t, m\u1ea5t nh\u00e2n c\u00e1ch, g\u00e2y m\u00ea, m\u1ea5t th\u1ecb l\u1ef1c tho\u00e1ng qua, xo\u1eafn \u0111\u1ec9nh, ng\u1eebng tim, r\u1ed1i lo\u1ea1n nh\u1ecbp tim ch\u01b0a x\u00e1c \u0111\u1ecbnh, vi\u00eam m\u1ea1ch, vi\u00eam gan m\u1ea1n t\u00ednh ti\u1ebfn tri\u1ec3n th\u00e0nh suy gan g\u00e2y t\u1eed vong, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Stevens-Johnson, \u0111\u1ee9t g\u00e2n, nh\u01b0\u1ee3c c\u01a1, vi\u00eam kh\u1edbp, c\u1ee9ng c\u01a1.<\/p>\n<p>Kh\u00f4ng r\u00f5 t\u1ea7n su\u1ea5t: Ti\u00eau c\u01a1 v\u00e2n v\u00e0 ph\u1ea3n \u1ee9ng da c\u1ea5p t\u00ednh \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 xu\u1ea5t hi\u1ec7n lan t\u1ecfa c\u1ee7a c\u00e1c m\u1ee5n m\u1ee7 v\u00f4 khu\u1ea9n (AGEP).<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Ch\u1ec9 s\u1ed1 INR c\u1ea7n \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t th\u01b0\u1eddng xuy\u00ean v\u00e0 hi\u1ec7u ch\u1ec9nh li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng k\u1ecbp th\u1eddi khi ph\u1ed1i h\u1ee3p c\u00f9ng kh\u00e1ng sinh, do nhi\u1ec1u d\u1eef li\u1ec7u l\u00e2m s\u00e0ng cho th\u1ea5y ho\u1ea1t l\u1ef1c ch\u1ed1ng \u0111\u00f4ng b\u1ecb khu\u1ebfch \u0111\u1ea1i \u1edf ng\u01b0\u1eddi d\u00f9ng kh\u00e1ng sinh (ch\u1ee7 y\u1ebfu l\u00e0 fluoroquinolon, macrolid, tetracyclin, cotrimoxazol v\u00e0 m\u1ed9t s\u1ed1 cephalosporin), nh\u1ea5t l\u00e0 tr\u00ean n\u1ec1n b\u1ec7nh nh\u00e2n cao tu\u1ed5i, th\u1ec3 tr\u1ea1ng y\u1ebfu ho\u1eb7c \u0111ang nhi\u1ec5m khu\u1ea9n, vi\u00eam n\u1eb7ng.<\/p>\n<p>Ng\u01b0\u1ee3c l\u1ea1i, moxifloxacin kh\u00f4ng t\u1ea1o ra t\u01b0\u01a1ng t\u00e1c l\u00e2m s\u00e0ng khi d\u00f9ng chung v\u1edbi ranitidin, probenecid, thu\u1ed1c tr\u00e1nh thai u\u1ed1ng, calci b\u1ed5 sung, morphin t\u0129nh m\u1ea1ch, theophylin, cyclosporin hay itraconazol. C\u00e1c kh\u1ea3o s\u00e1t <i>in vitro<\/i> tr\u00ean ng\u01b0\u1eddi c\u0169ng kh\u1eb3ng \u0111\u1ecbnh t\u01b0\u01a1ng t\u00e1c chuy\u1ec3n h\u00f3a th\u00f4ng qua h\u1ec7 cytochrome P450 l\u00e0 kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ph\u00e1t sinh.<\/p>\n<p>Th\u1ef1c ph\u1ea9m v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m t\u1eeb s\u1eefa kh\u00f4ng t\u1ea1o ra t\u01b0\u01a1ng t\u00e1c l\u00e2m s\u00e0ng n\u00e0o v\u1edbi moxifloxacin.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Moxifloxacin kh\u00f4ng \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn trong \u0111i\u1ec1u tr\u1ecb cho ph\u1ee5 n\u1eef \u0111ang mang thai. Khuy\u1ebfn c\u00e1o n\u00e0y xu\u1ea5t ph\u00e1t t\u1eeb nh\u1eefng quan s\u00e1t v\u1ec1 \u0111\u1ed9c t\u00ednh \u0111\u1ed1i v\u1edbi ch\u1ee9c n\u0103ng sinh s\u1ea3n trong c\u00e1c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt, trong khi m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ebfn thai nhi \u1edf ng\u01b0\u1eddi hi\u1ec7n v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5. \u0110\u00e1ng ch\u00fa \u00fd, fluoroquinolon c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i \u0111\u1ebfn qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 th\u1ed1ng s\u1ee5n kh\u1edbp, \u0111\u1eb7c bi\u1ec7t t\u1ea1i c\u00e1c v\u1ecb tr\u00ed ph\u1ea3i ch\u1ecbu t\u1ea3i tr\u1ecdng c\u01a1 th\u1ec3. Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p t\u1ed5n th\u01b0\u01a1ng kh\u1edbp c\u00f3 kh\u1ea3 n\u0103ng h\u1ed3i ph\u1ee5c c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf tr\u1ebb em d\u00f9ng nh\u00f3m kh\u00e1ng sinh n\u00e0y.<\/p>\n<p>Moxifloxacin c\u00f3 kh\u1ea3 n\u0103ng \u0111i v\u00e0o s\u1eefa m\u1eb9, m\u1eb7c d\u00f9 l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt \u1edf m\u1ee9c th\u1ea5p. Hi\u1ec7n v\u1eabn ch\u01b0a c\u00f3 s\u1ed1 li\u1ec7u nghi\u00ean c\u1ee9u t\u01b0\u01a1ng \u1ee9ng tr\u00ean ng\u01b0\u1eddi \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m c\u1ee7a tr\u1ebb b\u00fa m\u1eb9. B\u00ean c\u1ea1nh \u0111\u00f3, nh\u1eefng t\u1ed5n th\u01b0\u01a1ng s\u1ee5n kh\u1edbp ch\u1ecbu l\u1ef1c \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf \u0111\u1ed9ng v\u1eadt non khi ti\u1ebfp x\u00fac v\u1edbi fluoroquinolon l\u00e0 c\u01a1 s\u1edf \u0111\u1ec3 th\u1eadn tr\u1ecdng v\u1edbi nguy c\u01a1 tr\u00ean tr\u1ebb nh\u1ecf. V\u00ec v\u1eady, vi\u1ec7c cho con b\u00fa b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong su\u1ed1t th\u1eddi gian ng\u01b0\u1eddi m\u1eb9 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng moxifloxacin.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n th\u1eadn tr\u1ecdng khi tham gia giao th\u00f4ng ho\u1eb7c l\u00e0m vi\u1ec7c v\u1edbi thi\u1ebft b\u1ecb \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o trong th\u1eddi gian s\u1eed d\u1ee5ng moxifloxacin. M\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c nh\u01b0 ch\u00f3ng m\u1eb7t, thay \u0111\u1ed5i th\u1ecb l\u1ef1c tho\u00e1ng qua ho\u1eb7c ng\u1ea5t c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n \u0111\u1ed9t ng\u1ed9t, g\u00e2y m\u1ea5t ki\u1ec3m so\u00e1t trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y. \u0110\u00e2y c\u0169ng l\u00e0 nh\u1eefng \u1ea3nh h\u01b0\u1edfng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn v\u1edbi nh\u00f3m fluoroquinolon li\u00ean quan \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. Do ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u chuy\u00ean bi\u1ec7t x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 t\u00e1c \u0111\u1ed9ng c\u1ee7a moxifloxacin, ng\u01b0\u1eddi b\u1ec7nh n\u00ean \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ea3n th\u00e2n tr\u01b0\u1edbc khi quy\u1ebft \u0111\u1ecbnh l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng moxifloxacin qu\u00e1 li\u1ec1u, vi\u1ec7c x\u1eed tr\u00ed ch\u1ee7 y\u1ebfu t\u1eadp trung v\u00e0o ki\u1ec3m so\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng xu\u1ea5t hi\u1ec7n v\u00e0 gi\u00e1m s\u00e1t \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 \u0111\u1ec3 ph\u00e1t hi\u1ec7n nguy c\u01a1 QT k\u00e9o d\u00e0i do ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho t\u00ecnh tr\u1ea1ng n\u00e0y. \u0110\u1ed1i v\u1edbi tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u qua \u0111\u01b0\u1eddng u\u1ed1ng, than ho\u1ea1t n\u00ean \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng s\u1edbm khi thu\u1ed1c v\u1eabn \u0111ang trong giai \u0111o\u1ea1n h\u1ea5p thu nh\u1eb1m h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t \u0111i v\u00e0o tu\u1ea7n ho\u00e0n. Khi d\u00f9ng c\u00f9ng 400mg moxifloxacin, than ho\u1ea1t l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c tr\u00ean 80% n\u1ebfu d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 kho\u1ea3ng 20% n\u1ebfu d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Ratida 400mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Ratida 400mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Ratida 400mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Ratida 400mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Ratida 400mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Ratida 400mg c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Ratida 400mg t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Ratida 400mg nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/moloxcin-400\/\">Moloxcin 400<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Moxifloxacin (d\u01b0\u1edbi d\u1ea1ng Moxifloxacin hydroclorid) 400mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi Moxifloxacin<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/avelox-400mg-bayer\/\">Avelox 400mg Bayer<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Moxifloxacin (d\u01b0\u1edbi d\u1ea1ng Moxifloxacin hydroclorid) 400mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Bayer AG, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi Moxifloxacin<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Tulkens PM, Arvis P, Kruesmann F (2012). Moxifloxacin safety: an analysis of 14 years of clinical data. Drugs R D. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 11 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3585838\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3585838\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Ratida 400mg ch\u1ee9a Moxifloxacin 400mg l\u00e0 kh\u00e1ng sinh \u0111\u01b0\u1eddng u\u1ed1ng d\u1ea1ng vi\u00ean n\u00e9n gi\u00fap \u0111i\u1ec1u tr\u1ecb vi\u00eam ph\u1ed5i c\u1ed9ng \u0111\u1ed3ng, nhi\u1ec5m khu\u1ea9n da, m\u00f4 m\u1ec1m v\u00e0 nhi\u1ec5m tr\u00f9ng \u1ed5 b\u1ee5ng ph\u1ee9c t\u1ea1p.<\/p>\n","protected":false},"author":1,"featured_media":164934,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-164913","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/164913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=164913"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/164934"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=164913"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=164913"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=164913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}