{"id":164535,"date":"2026-11-03T15:17:50","date_gmt":"2026-11-03T08:17:50","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=164535"},"modified":"2026-11-03T15:19:28","modified_gmt":"2026-11-03T08:19:28","slug":"cresemba-100mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/cresemba-100mg\/","title":{"rendered":"Cresemba 100mg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Cresemba 100mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi SwissCo Services AG c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 760110441723<\/b><\/p>\n<h2>Cresemba 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i vi\u00ean <b>Cresemba 100mg<\/b> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Isavuconazole (d\u01b0\u1edbi d\u1ea1ng Isavuconazonium sulfate): 100mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u01b0\u0301ng<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 760110441723<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 7 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Switzerland<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 30 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Cresemba 100mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>C\u01a1 ch\u1ebf kh\u00e1ng n\u1ea5m c\u1ee7a ho\u1ea1t ch\u1ea5t Isavuconazole d\u1ef1a tr\u00ean vi\u1ec7c c\u1ea3n tr\u1edf qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p ergosterol &#8211; th\u00e0nh ph\u1ea7n thi\u1ebft y\u1ebfu c\u1ea5u t\u1ea1o n\u00ean m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m. C\u1ee5 th\u1ec3, ph\u00e2n t\u1eed n\u00e0y v\u00f4 hi\u1ec7u h\u00f3a enzyme lanosterol 14-alpha-demethylase ph\u1ee5 thu\u1ed9c cytochrome P-450, v\u1ed1n \u0111\u00f3ng vai tr\u00f2 x\u00fac t\u00e1c ph\u1ea3n \u1ee9ng chuy\u1ec3n h\u00f3a lanosterol th\u00e0nh ergosterol. Do ergosterol l\u00e0 th\u00e0nh ph\u1ea7n thi\u1ebft y\u1ebfu c\u1ea5u t\u1ea1o m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m, s\u1ef1 \u1ee9c ch\u1ebf n\u00e0y l\u00e0m gi\u00e1n \u0111o\u1ea1n qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p sterol, khi\u1ebfn c\u00e1c ti\u1ec1n ch\u1ea5t sterol \u0111\u00e3 methyl h\u00f3a t\u00edch t\u1ee5 trong t\u1ebf b\u00e0o, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng ergosterol trong m\u00e0ng. H\u1eadu qu\u1ea3 l\u00e0 c\u1ea5u tr\u00fac m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m b\u1ecb bi\u1ebfn \u0111\u1ed5i, k\u00e9o theo s\u1ef1 suy gi\u1ea3m v\u1ec1 t\u00ednh to\u00e0n v\u1eb9n v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a m\u00e0ng.<button class=\"rank-math-content-ai-tooltip\">R\u00fat g\u1ecdn b\u1eb1ng AI<\/button><\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>\u1ede d\u1ea1ng ti\u1ec1n d\u01b0\u1ee3c, isavuconazonium sulfate c\u00f3 \u0111\u1eb7c t\u00ednh tan trong n\u01b0\u1edbc v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1eb1ng hai \u0111\u01b0\u1eddng l\u00e0 u\u1ed1ng vi\u00ean nang c\u1ee9ng ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch. Sau khi \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3, c\u00e1c esterase c\u00f3 trong huy\u1ebft t\u01b0\u01a1ng nhanh ch\u00f3ng ph\u00e2n c\u1eaft ti\u1ec1n d\u01b0\u1ee3c \u0111\u1ec3 t\u1ea1o th\u00e0nh isavuconazole, ho\u1ea1t ch\u1ea5t tr\u1ef1c ti\u1ebfp ph\u00e1t huy t\u00e1c d\u1ee5ng. V\u00ec \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nhanh n\u00ean ti\u1ec1n d\u01b0\u1ee3c ch\u1ec9 t\u1ed3n t\u1ea1i trong huy\u1ebft t\u01b0\u01a1ng v\u1edbi l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf v\u00e0 kh\u00f3 ph\u00e1t hi\u1ec7n k\u00e9o d\u00e0i, \u0111\u1eb7c bi\u1ec7t sau khi s\u1eed d\u1ee5ng qua \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n<p>H\u1ea5p thu: Isavuconazole c\u00f3 trong Cresemba \u0111\u01b0\u1ee3c h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 \u0111\u1ea1t m\u1ee9c n\u1ed3ng \u0111\u1ed9 cao nh\u1ea5t trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 2-3 gi\u1edd k\u1ec3 t\u1eeb khi u\u1ed1ng. Vi\u1ec7c d\u00f9ng Cresemba t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 400mg isavuconazole trong b\u1eefa \u0103n gi\u00e0u ch\u1ea5t b\u00e9o l\u00e0m thay \u0111\u1ed5i m\u1ed9t s\u1ed1 th\u00f4ng s\u1ed1 h\u1ea5p thu, c\u1ee5 th\u1ec3 Cmax gi\u1ea3m 9% nh\u01b0ng AUC l\u1ea1i t\u0103ng 9% so v\u1edbi khi kh\u00f4ng d\u00f9ng c\u00f9ng th\u1ee9c \u0103n. Do m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng kh\u00f4ng l\u00e0m thay \u0111\u1ed5i y\u00eau c\u1ea7u s\u1eed d\u1ee5ng, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 u\u1ed1ng thu\u1ed1c \u0111\u1ed9c l\u1eadp v\u1edbi b\u1eefa \u0103n.<\/p>\n<p>Ph\u00e2n b\u1ed1: Sau khi h\u1ea5p thu, isavuconazole ph\u00e2n t\u00e1n r\u1ed9ng trong c\u00e1c m\u00f4 v\u00e0 d\u1ecbch c\u01a1 th\u1ec3, th\u1ec3 hi\u1ec7n qua th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t kho\u1ea3ng 450 L. Ph\u1ea7n l\u1edbn thu\u1ed1c l\u01b0u h\u00e0nh trong m\u00e1u \u1edf tr\u1ea1ng th\u00e1i g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, v\u1edbi t\u1ef7 l\u1ec7 li\u00ean k\u1ebft v\u01b0\u1ee3t 99%, albumin l\u00e0 protein \u0111\u1ea3m nhi\u1ec7m vai tr\u00f2 li\u00ean k\u1ebft ch\u00ednh.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: C\u00e1c d\u1eef li\u1ec7u thu \u0111\u01b0\u1ee3c t\u1eeb th\u1eed nghi\u1ec7m in vitro v\u00e0 in vivo cho th\u1ea5y isavuconazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00f4ng qua ho\u1ea1t \u0111\u1ed9ng c\u1ee7a CYP3A4 v\u00e0 CYP3A5, \u0111\u1ed3ng th\u1eddi c\u00f3 s\u1ef1 tham gia c\u1ee7a c\u00e1c enzym uridine diphosphate-glucuronosyltransferase (UGT) \u1edf giai \u0111o\u1ea1n ti\u1ebfp theo. K\u1ebft qu\u1ea3 ph\u00e2n t\u00edch sau khi d\u00f9ng m\u1ed9t li\u1ec1u isavuconazonium sulfate \u0111\u01b0\u1ee3c \u0111\u00e1nh d\u1ea5u ph\u00f3ng x\u1ea1 b\u1eb1ng hai d\u1ea1ng \u0111\u1ed3ng v\u1ecb kh\u00e1c nhau cho th\u1ea5y trong c\u01a1 th\u1ec3 c\u00f3 isavuconazole, s\u1ea3n ph\u1ea9m ph\u00e2n h\u1ee7y kh\u00f4ng c\u00f2n ho\u1ea1t t\u00ednh v\u00e0 m\u1ed9t s\u1ed1 ch\u1ea5t chuy\u1ec3n h\u00f3a th\u1ee9 c\u1ea5p. X\u00e9t ri\u00eang t\u1eebng ch\u1ea5t, kh\u00f4ng c\u00f3 ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0o ngo\u00e0i isavuconazole \u0111\u1ea1t AUC l\u1edbn h\u01a1n 10% t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e1nh d\u1ea5u ph\u00f3ng x\u1ea1.<\/p>\n<p>Th\u1ea3i tr\u1eeb: D\u1eef li\u1ec7u thu h\u1ed3i ph\u00f3ng x\u1ea1 sau khi ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh u\u1ed1ng isavuconazonium sulfate c\u00f3 \u0111\u00e1nh d\u1ea5u cho th\u1ea5y thu\u1ed1c v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m li\u00ean quan \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua c\u1ea3 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a l\u1eabn \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u. T\u1ef7 l\u1ec7 ph\u00f3ng x\u1ea1 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e2n \u0111\u1ea1t trung b\u00ecnh 46,1% li\u1ec1u \u0111\u00e3 d\u00f9ng, trong khi l\u01b0\u1ee3ng thu h\u1ed3i qua n\u01b0\u1edbc ti\u1ec3u l\u00e0 45,5%. Ri\u00eang isavuconazole \u1edf d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a ch\u1ec9 chi\u1ebfm d\u01b0\u1edbi 1% li\u1ec1u d\u00f9ng khi \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua th\u1eadn. S\u1ea3n ph\u1ea9m ph\u00e2n h\u1ee7y kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh ch\u1ee7 y\u1ebfu tr\u1ea3i qua qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a, sau \u0111\u00f3 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<h2>Thu\u1ed1c Cresemba 100mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Cresemba \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc c\u00e1c b\u1ec7nh nhi\u1ec5m n\u1ea5m x\u00e2m l\u1ea5n, bao g\u1ed3m nhi\u1ec5m Aspergillus v\u00e0 nhi\u1ec5m n\u1ea5m thu\u1ed9c nh\u00f3m Mucorales \u1edf nh\u1eefng tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng ph\u00f9 h\u1ee3p \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng amphotericin B<\/p>\n<figure id=\"attachment_164553\" aria-describedby=\"caption-attachment-164553\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-164553\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg.jpg\" alt=\"Cresemba 100mg \" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/Cresemba-100mg-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-164553\" class=\"wp-caption-text\">Thu\u1ed1c Cresemba 100mg \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m n\u1ea5m x\u00e2m l\u1ea5n do Aspergillus v\u00e0 Mucorales<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Li\u1ec1u t\u1ea5n c\u00f4ng: Trong 2 ng\u00e0y \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, ng\u01b0\u1eddi b\u1ec7nh s\u1eed d\u1ee5ng 2 vi\u00ean nang Cresemba m\u1ed7i l\u1ea7n, t\u01b0\u01a1ng \u1ee9ng 200mg isavuconazole. C\u00e1c l\u1ea7n u\u1ed1ng c\u00e1ch nhau 8 gi\u1edd, th\u1ef1c hi\u1ec7n t\u1ed5ng c\u1ed9ng 6 l\u1ea7n trong 48 gi\u1edd \u0111\u1ea7u ti\u00ean.<\/p>\n<p>Li\u1ec1u duy tr\u00ec: Sau khi ho\u00e0n th\u00e0nh li\u1ec1u t\u1ea5n c\u00f4ng t\u1eeb 12-24 gi\u1edd, chuy\u1ec3n sang d\u00f9ng 2 vi\u00ean nang (200mg isavuconazole) m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n.<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: Li\u1ec7u tr\u00ecnh \u0111\u01b0\u1ee3c duy tr\u00ec t\u00f9y theo di\u1ec5n bi\u1ebfn b\u1ec7nh v\u00e0 kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng ng\u01b0\u1eddi b\u1ec7nh. N\u1ebfu th\u1eddi gian s\u1eed d\u1ee5ng v\u01b0\u1ee3t qu\u00e1 6 th\u00e1ng, c\u1ea7n \u0111\u00e1nh gi\u00e1 th\u1eadn tr\u1ecdng l\u1ee3i \u00edch thu \u0111\u01b0\u1ee3c so v\u1edbi nh\u1eefng nguy c\u01a1 c\u00f3 th\u1ec3 ph\u00e1t sinh trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea7n thay \u0111\u1ed5i li\u1ec1u khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn tu\u1ed5i, m\u1eb7c d\u00f9 kinh nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb tr\u00ean nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y v\u1eabn c\u00f2n h\u1ea1n ch\u1ebf.<\/li>\n<li>Ng\u01b0\u1eddi suy th\u1eadn: Kh\u00f4ng y\u00eau c\u1ea7u hi\u1ec7u ch\u1ec9nh li\u1ec1u, k\u1ec3 c\u1ea3 tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i.<\/li>\n<li>Ng\u01b0\u1eddi suy gan: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gan nh\u1eb9 ho\u1eb7c trung b\u00ecnh (Child-Pugh A, B). V\u1edbi ng\u01b0\u1eddi suy gan n\u1eb7ng (Child-Pugh C), do ch\u01b0a c\u00f3 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 n\u00ean kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng thu\u1ed1c, tr\u1eeb khi b\u00e1c s\u0129 nh\u1eadn \u0111\u1ecbnh l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1.<\/li>\n<li>Tr\u1ebb em: Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u x\u00e1c l\u1eadp hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a Cresemba \u1edf tr\u1ebb d\u01b0\u1edbi 18 tu\u1ed5i n\u00ean hi\u1ec7n ch\u01b0a c\u00f3 khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho nh\u00f3m n\u00e0y.<\/li>\n<\/ul>\n<p>L\u01b0u \u00fd khi chuy\u1ec3n \u0111\u1ed5i \u0111\u01b0\u1eddng d\u00f9ng: Cresemba c\u00f3 sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 98%, do \u0111\u00f3 c\u00f3 th\u1ec3 chuy\u1ec3n \u0111\u1ed5i gi\u1eefa d\u1ea1ng u\u1ed1ng v\u00e0 d\u1ea1ng ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p><b>Vi\u00ean nang Cresemba 100mg<\/b> \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Cresemba 100mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi isavuconazole ho\u1eb7c t\u00e1 d\u01b0\u1ee3c c\u00f3 trong Cresemba 100mg<\/p>\n<p>S\u1eed d\u1ee5ng chung v\u1edbi ritonavir (\u1edf m\u1ee9c li\u1ec1u cao v\u01b0\u1ee3t ng\u01b0\u1ee1ng 200mg m\u1ed7i 12 gi\u1edd) ho\u1eb7c v\u1edbi ketoconazole<\/p>\n<p>S\u1eed chung v\u1edbi c\u00e1c thu\u1ed1c nh\u01b0 phenytoin, carbamazepine, rifabutin, rifampicin, St. John&#8217;s wort ho\u1eb7c barbiturat c\u00f3 th\u1eddi gian t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i nh\u01b0 phenobarbital do kh\u1ea3 n\u0103ng c\u1ea3m \u1ee9ng m\u1ea1nh enzym CYP3A4\/5.<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi efavirenz, etravirine v\u00e0 nafcillin, l\u00e0 nh\u1eefng thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng c\u1ea3m \u1ee9ng CYP3A4\/5 \u1edf m\u1ee9c trung b\u00ecnh.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc h\u1ed9i ch\u1ee9ng QT ng\u1eafn do y\u1ebfu t\u1ed1 di truy\u1ec1n trong gia \u0111\u00ecnh<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>C\u1ea7n c\u00e2n nh\u1eafc th\u1eadn tr\u1ecdng tr\u01b0\u1edbc khi ch\u1ec9 \u0111\u1ecbnh isavuconazole cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng n\u1ea5m thu\u1ed9c nh\u00f3m azole.<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng isavuconazole \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng QT ng\u1eafn c\u00f3 t\u00ednh gia \u0111\u00ecnh. Tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ec7nh \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m r\u00fat ng\u1eafn kho\u1ea3ng QT, ch\u1eb3ng h\u1ea1n rufinamide, c\u1ea7n \u0111\u1eb7c bi\u1ec7t th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng t\u0103ng transaminase ho\u1eb7c vi\u00eam gan. Vi\u1ec7c ki\u1ec3m tra men gan n\u00ean \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc d\u1ef1a tr\u00ean bi\u1ec3u hi\u1ec7n v\u00e0 t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng c\u1ee7a t\u1eebng tr\u01b0\u1eddng h\u1ee3p.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gan m\u1ee9c \u0111\u1ed9 n\u1eb7ng (Child-Pugh C), hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 isavuconazole. V\u00ec v\u1eady, kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c \u1edf nh\u00f3m n\u00e0y, tr\u1eeb tr\u01b0\u1eddng h\u1ee3p l\u1ee3i \u00edch d\u1ef1 ki\u1ebfn cao h\u01a1n nguy c\u01a1, n\u1ebfu v\u1eabn c\u1ea7n \u0111i\u1ec1u tr\u1ecb, ph\u1ea3i gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea5u hi\u1ec7u nhi\u1ec5m \u0111\u1ed9c.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 c\u1ee7a isavuconazole trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m n\u1ea5m Mucorales ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 tr\u00ean ph\u1ea1m vi r\u1ed9ng. D\u1eef li\u1ec7u hi\u1ec7n c\u00f3 ch\u1ee7 y\u1ebfu \u0111\u1ebfn t\u1eeb m\u1ed9t nghi\u00ean c\u1ee9u ti\u1ebfn c\u1ee9u kh\u00f4ng c\u00f3 nh\u00f3m \u0111\u1ed1i ch\u1ee9ng v\u1edbi 37 b\u1ec7nh nh\u00e2n, s\u1ed1 li\u1ec7u v\u1ec1 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb \u1edf t\u1eebng lo\u00e0i c\u0169ng nh\u01b0 \u0111\u1ed9 nh\u1ea1y v\u1edbi thu\u1ed1c c\u00f2n h\u1ea1n ch\u1ebf. Ngo\u00e0i ra, ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh li\u1ec1u ri\u00eang cho nhi\u1ec5m n\u1ea5m Mucorales, do \u0111\u00f3 li\u1ec1u s\u1eed d\u1ee5ng hi\u1ec7n t\u01b0\u01a1ng t\u1ef1 ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m Aspergillus x\u00e2m l\u1ea5n.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 g\u1eb7p t\u00ecnh tr\u1ea1ng m\u1ec7t m\u1ecfi, \u0111au ng\u1ef1c, suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, ng\u1ee9a, ph\u00e1t ban, t\u0103ng men gan v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng gan. Nh\u1eefng bi\u1ec3u hi\u1ec7n kh\u00e1c \u0111\u01b0\u1ee3c ghi nh\u1eadn g\u1ed3m \u0111au b\u1ee5ng, n\u00f4n, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, kh\u00f3 th\u1edf, suy h\u00f4 h\u1ea5p c\u1ea5p, vi\u00eam t\u1eafc t\u0129nh m\u1ea1ch, ng\u1ee7 g\u00e0, \u0111au \u0111\u1ea7u, m\u00ea s\u1ea3ng, ch\u00e1n \u0103n v\u00e0 h\u1ea1 kali m\u00e1u.<\/p>\n<p>\u00cdt g\u1eb7p: C\u00e1c bi\u1ec3u hi\u1ec7n c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n bao g\u1ed3m suy nh\u01b0\u1ee3c, c\u1ea3m gi\u00e1c kh\u00f4ng kh\u1ecfe, \u0111au l\u01b0ng, vi\u00eam da, ban \u0111\u1ecf nhi\u1ec5m s\u1eafc do thu\u1ed1c, r\u1ee5ng t\u00f3c v\u00e0 xu\u1ea5t huy\u1ebft d\u1ea1ng ch\u1ea5m d\u01b0\u1edbi da. Ngo\u00e0i ra, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 g\u1eb7p vi\u00eam gan, gan l\u00e1ch to, \u0111\u1ea7y h\u01a1i, t\u00e1o b\u00f3n, kh\u00f3 ti\u00eau, ch\u1ea3y m\u00e1u m\u0169i, ho ra m\u00e1u, th\u1edf nhanh\u2026.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Ketoconazole kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi isavuconazole do kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf CYP3A4\/5 m\u1ea1nh, d\u1eabn \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 isavuconazole trong huy\u1ebft t\u01b0\u01a1ng t\u0103ng \u0111\u00e1ng k\u1ec3.<\/p>\n<p>Khi k\u1ebft h\u1ee3p v\u1edbi lopinavir\/ritonavir, m\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m isavuconazole \u0111\u01b0\u1ee3c ghi nh\u1eadn t\u0103ng l\u00ean kho\u1ea3ng 2 l\u1ea7n.<\/p>\n<p>Clarithromycin, indinavir v\u00e0 saquinavir c\u0169ng thu\u1ed9c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4\/5 m\u1ea1nh, c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 isavuconazole, m\u1eb7c d\u00f9 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng kh\u00f4ng gi\u1ed1ng nhau gi\u1eefa c\u00e1c thu\u1ed1c.<\/p>\n<p>Vi\u1ec7c ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4\/5 kh\u00f4ng \u0111\u00f2i h\u1ecfi thay \u0111\u1ed5i li\u1ec1u isavuconazole, k\u1ec3 c\u1ea3 khi m\u1ee9c \u0111\u1ed9 \u1ee9c ch\u1ebf enzym m\u1ea1nh. Tuy nhi\u00ean, c\u1ea7n ch\u00fa \u00fd theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh v\u00ec nguy c\u01a1 g\u1eb7p ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u00f3 th\u1ec3 t\u0103ng l\u00ean.<\/p>\n<p>Rifampicin, rifabutin, carbamazepine, phenytoin, phenobarbital, St. John&#8217;s wort, efavirenz, nafcillin v\u00e0 etravirine kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng isavuconazole. Nh\u1eefng ho\u1ea1t ch\u1ea5t n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng k\u00edch th\u00edch CYP3A4\/5 \u1edf m\u1ee9c m\u1ea1nh ho\u1eb7c trung b\u00ecnh, khi\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c kh\u00e1ng n\u1ea5m trong huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m \u0111\u00e1ng k\u1ec3.<\/p>\n<p>Ritonavir \u1edf m\u1ee9c li\u1ec1u v\u01b0\u1ee3t qu\u00e1 200mg\/l\u1ea7n, d\u00f9ng 2 l\u1ea7n m\u1ed7i ng\u00e0y, c\u0169ng n\u1eb1m trong nh\u00f3m ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p. Nguy\u00ean nh\u00e2n l\u00e0 ritonavir \u1edf li\u1ec1u cao c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t CYP3A4\/5, l\u00e0m t\u0103ng chuy\u1ec3n h\u00f3a v\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 isavuconazole.<\/p>\n<p>V\u1edbi aprepitant, prednisone v\u00e0 pioglitazone, c\u1ea7n c\u00e2n nh\u1eafc k\u1ef9 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng c\u00f9ng isavuconazole do kh\u1ea3 n\u0103ng c\u1ea3m \u1ee9ng CYP3A4\/5 \u1edf m\u1ee9c nh\u1eb9. Ch\u1ec9 n\u00ean ph\u1ed1i h\u1ee3p khi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 cao h\u01a1n nh\u1eefng nguy c\u01a1 ti\u1ec1m \u1ea9n.<\/p>\n<p>Ngo\u00e0i vai tr\u00f2 l\u00e0 c\u01a1 ch\u1ea5t chuy\u1ec3n h\u00f3a, isavuconazole c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf CYP3A4\/5 \u1edf m\u1ee9c trung b\u00ecnh. \u0110\u1eb7c t\u00ednh n\u00e0y c\u00f3 th\u1ec3 khi\u1ebfn c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a nh\u1edd enzym CYP3A4\/5 b\u1ecb gi\u1ea3m t\u1ed1c \u0111\u1ed9 chuy\u1ec3n h\u00f3a v\u00e0 t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Ho\u1ea1t t\u00ednh c\u1ee7a CYP2B6 c\u00f3 th\u1ec3 t\u0103ng nh\u1eb9 d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a isavuconazole, t\u1eeb \u0111\u00f3 th\u00fac \u0111\u1ea9y chuy\u1ec3n h\u00f3a v\u00e0 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u00e1c thu\u1ed1c ph\u1ee5 thu\u1ed9c enzym n\u00e0y trong m\u00e1u.<\/p>\n<p>P-glycoprotein t\u1ea1i ru\u1ed9t c\u0169ng ch\u1ecbu \u1ea3nh h\u01b0\u1edfng t\u1eeb isavuconazole th\u00f4ng qua c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf nh\u1eb9. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o tu\u1ea7n ho\u00e0n \u0111\u1ed1i v\u1edbi nh\u1eefng ho\u1ea1t ch\u1ea5t l\u00e0 c\u01a1 ch\u1ea5t c\u1ee7a P-gp.<\/p>\n<p>K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u in vitro cho th\u1ea5y isavuconazole c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf BCRP. V\u00ec v\u1eady, n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c v\u1eadn chuy\u1ec3n b\u1edfi protein n\u00e0y c\u00f3 th\u1ec3 t\u0103ng khi d\u00f9ng ph\u1ed1i h\u1ee3p, c\u1ea7n l\u01b0u \u00fd nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>\u0110\u1ed1i v\u1edbi OCT2 (Organic Cation Transporter 2), isavuconazole g\u00e2y \u1ee9c ch\u1ebf nh\u1eb9 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a protein v\u1eadn chuy\u1ec3n n\u00e0y t\u1ea1i th\u1eadn. H\u1ec7 qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0 s\u1ef1 \u0111\u00e0o th\u1ea3i c\u00e1c thu\u1ed1c ph\u1ee5 thu\u1ed9c OCT2 b\u1ecb \u1ea3nh h\u01b0\u1edfng, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a ch\u00fang trong tu\u1ea7n ho\u00e0n.<\/p>\n<p>Qu\u00e1 tr\u00ecnh glucuronid h\u00f3a th\u00f4ng qua enzym UGT c\u0169ng c\u00f3 th\u1ec3 b\u1ecb isavuconazole t\u00e1c \u0111\u1ed9ng do kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf enzym \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9. Khi d\u00f9ng chung, c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua con \u0111\u01b0\u1eddng n\u00e0y c\u00f3 th\u1ec3 t\u0103ng nh\u1eb9 n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ch\u01b0a c\u00f3 b\u00e1o c\u00e1o v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Cresemba tr\u00ean ph\u1ee5 n\u1eef trong th\u1eddi k\u1ef3 mang thai. M\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c hi\u1ec7n tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 ghi nh\u1eadn t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n, m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng v\u00e0 nguy c\u01a1 \u0111\u1ed1i v\u1edbi thai nhi \u1edf ng\u01b0\u1eddi hi\u1ec7n v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Cresemba. Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m n\u1ea5m \u0111\u1eb7c bi\u1ec7t nghi\u00eam tr\u1ecdng ho\u1eb7c \u0111e d\u1ecda t\u00ednh m\u1ea1ng, khi isavuconazole \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 c\u1ea7n thi\u1ebft v\u00e0 l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi m\u1eb9 v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1 c\u00f3 th\u1ec3 x\u1ea3y ra \u0111\u1ed1i v\u1edbi thai nhi.<\/p>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng c\u1ee7a isavuconazole l\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n \u1edf ng\u01b0\u1eddi, c\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt c\u0169ng kh\u00f4ng ghi nh\u1eadn \u0111\u1ed9c t\u00ednh l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng sinh s\u1ea3n. Kh\u00f4ng s\u1eed d\u1ee5ng Cresemba cho ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh \u0111\u1ebb n\u1ebfu kh\u00f4ng \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3.<\/p>\n<p>Th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt ghi nh\u1eadn isavuconazole v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 kh\u1ea3 n\u0103ng ti\u1ebft v\u00e0o s\u1eefa m\u1eb9, do \u0111\u00f3 kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb r\u1ee7i ro \u0111\u1ed1i v\u1edbi tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb nh\u1ecf. B\u1ec7nh nh\u00e2n b\u1eaft bu\u1ed9c ph\u1ea3i ng\u1eebng cho con b\u00fa trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Cresemba.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Isavuconazole c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u1edf m\u1ee9c \u0111\u1ed9 v\u1eeba ph\u1ea3i \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u1eadp trung khi l\u00e1i xe ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c. Khi xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u nh\u01b0 ch\u00f3ng m\u1eb7t, ng\u1ee7 g\u00e0, cho\u00e1ng ng\u1ea5t ho\u1eb7c gi\u1ea3m t\u1ec9nh t\u00e1o, ng\u01b0\u1eddi b\u1ec7nh tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng l\u00e0m c\u00e1c c\u00f4ng vi\u1ec7c c\u1ea7n s\u1ef1 an to\u00e0n n\u00e0y.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>So v\u1edbi nh\u00f3m d\u00f9ng isavuconazole \u1edf m\u1ee9c li\u1ec1u \u0111i\u1ec1u tr\u1ecb 200mg\/ng\u00e0y, nh\u00f3m \u0111\u01b0\u1ee3c d\u00f9ng li\u1ec1u cao h\u01a1n, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 600mg\/ng\u00e0y, ghi nh\u1eadn t\u1ef7 l\u1ec7 g\u1eb7p m\u1ed9t s\u1ed1 bi\u1ec3u hi\u1ec7n b\u1ea5t l\u1ee3i cao h\u01a1n trong nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 kho\u1ea3ng QT. Nh\u1eefng bi\u1ec3u hi\u1ec7n n\u00e0y li\u00ean quan \u0111\u1ebfn nhi\u1ec1u c\u01a1 quan v\u00e0 ch\u1ee9c n\u0103ng kh\u00e1c nhau, g\u1ed3m \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, d\u1ecb c\u1ea3m, ng\u1ee7 g\u00e0, suy gi\u1ea3m kh\u1ea3 n\u0103ng ch\u00fa \u00fd, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, kh\u00f4 mi\u1ec7ng, gi\u1ea3m c\u1ea3m gi\u00e1c v\u00f9ng mi\u1ec7ng, ti\u00eau ch\u1ea3y, n\u00f4n, n\u00f3ng b\u1eebng m\u1eb7t, lo \u00e2u, b\u1ed3n ch\u1ed3n, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, nh\u1ecbp tim nhanh, s\u1ee3 \u00e1nh s\u00e1ng v\u00e0 \u0111au kh\u1edbp.<\/p>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u \u0111\u1ed1i v\u1edbi isavuconazole v\u00e0 ho\u1ea1t ch\u1ea5t n\u00e0y c\u0169ng kh\u00f4ng \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf kh\u1ecfi tu\u1ea7n ho\u00e0n b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u. Do \u0111\u00f3, khi ng\u01b0\u1eddi b\u1ec7nh s\u1eed d\u1ee5ng thu\u1ed1c qu\u00e1 li\u1ec1u Cresemba, vi\u1ec7c x\u1eed tr\u00ed ch\u1ee7 y\u1ebfu d\u1ef1a tr\u00ean c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Cresemba 100mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Cresemba 100mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Cresemba 100mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Cresemba 100mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Cresemba 100mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Cresemba 100mg c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Cresemba 100mg \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/11\/To-huong-dan-su-dung-Cresemba-100mg-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 3 th\u00e1ng 11 n\u0103m 2026<\/li>\n<li>Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd (2022). New Perspectives on Antimicrobial Agents: Isavuconazole. Antimicrob Agents Chemother. Truy c\u1eadp ng\u00e0y 3 th\u00e1ng 11 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35969068\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35969068\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Cresemba 100mg ch\u1ee9a isavuconazole h\u00e0m l\u01b0\u1ee3ng 100mg, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m n\u1ea5m Aspergillus x\u00e2m l\u1ea5n v\u00e0 nhi\u1ec5m n\u1ea5m Mucorales \u1edf ng\u01b0\u1eddi b\u1ec7nh tr\u01b0\u1edfng th\u00e0nh.<\/p>\n","protected":false},"author":1,"featured_media":164539,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-164535","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/164535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=164535"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/164539"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=164535"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=164535"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=164535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}