{"id":163139,"date":"2026-09-25T14:24:44","date_gmt":"2026-09-25T07:24:44","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=163139"},"modified":"2026-09-25T14:26:56","modified_gmt":"2026-09-25T07:26:56","slug":"thuoc-zival-7-5mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/thuoc-zival-7-5mg\/","title":{"rendered":"Zival 7.5mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Zival 7.5mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n s\u1ea3n xu\u1ea5t-th\u01b0\u01a1ng m\u1ea1i d\u01b0\u1ee3c ph\u1ea9m \u0110\u00f4ng Nam c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110086224 (S\u0110K c\u0169 VD-30722-18)<\/b><\/p>\n

Zival 7.5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\nTh\u00e0nh ph\u1ea7n<\/h3>\n
Trong m\u1ed7i vi\u00ean Zival 7.5mg<\/b> c\u00f3 ch\u1ee9a:<\/p>\n
\n
Meloxicam: 7,5mg<\/li>\n
T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n
Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: 893110086224 (S\u0110K c\u0169 VD-30722-18)<\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/p>\n
Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n
H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zival 7.5mg<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
Meloxicam thu\u1ed9c nh\u00f3m NSAID d\u1eabn xu\u1ea5t acid enolic, c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m vi\u00eam, gi\u1ea3m \u0111au v\u00e0 h\u1ea1 s\u1ed1t nh\u1edd l\u00e0m gi\u1ea3m qu\u00e1 tr\u00ecnh t\u1ea1o prostaglandin \u2013 c\u00e1c ch\u1ea5t trung gian \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ph\u1ea3n \u1ee9ng vi\u00eam. Thu\u1ed1c c\u00f3 xu h\u01b0\u1edbng \u1ee9c ch\u1ebf COX-2 ch\u1ecdn l\u1ecdc h\u01a1n COX-1, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m t\u1ed5ng h\u1ee3p prostaglandin t\u1ea1i v\u1ecb tr\u00ed vi\u00eam. T\u00ednh \u01b0u ti\u00ean tr\u00ean COX-2 \u0111\u01b0\u1ee3c cho l\u00e0 g\u00f3p ph\u1ea7n t\u1ea1o n\u00ean t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb, trong khi \u1ee9c ch\u1ebf COX-1 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 th\u1eadn.<\/p>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
Meloxicam c\u00f3 sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng r\u1ea5t cao, \u0111\u1ea1t kho\u1ea3ng 90% v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n hay c\u00e1c thu\u1ed1c kh\u00e1ng acid. C\u00e1c d\u1ea1ng d\u00f9ng nh\u01b0 vi\u00ean n\u00e9n, vi\u00ean nang hay h\u1ed7n d\u1ecbch c\u00f3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng sinh h\u1ecdc gi\u1ed1ng nhau. Sau khi u\u1ed1ng li\u1ec1u \u0111\u01a1n, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u \u0111\u1ea1t \u0111\u1ec9nh sau kho\u1ea3ng 2 gi\u1edd \u0111\u1ed1i v\u1edbi d\u1ea1ng h\u1ed7n d\u1ecbch v\u00e0 t\u1eeb 5 \u0111\u1ebfn 6 gi\u1edd \u0111\u1ed1i v\u1edbi d\u1ea1ng vi\u00ean c\u1ee9ng. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u0111\u1ea1t tr\u1ea1ng th\u00e1i c\u00e2n b\u1eb1ng \u1ed5n \u0111\u1ecbnh sau 3 \u0111\u1ebfn 5 ng\u00e0y \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c, \u0111\u1ed3ng th\u1eddi th\u1ec3 hi\u1ec7n t\u00ednh ch\u1ea5t d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u t\u1eeb 7,5 mg \u0111\u1ebfn 15 mg.<\/p>\n
Thu\u1ed1c c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p (kho\u1ea3ng 11 \u0111\u1ebfn 16 l\u00edt) nh\u01b0ng l\u1ea1i th\u00e2m nh\u1eadp r\u1ea5t t\u1ed1t v\u00e0o d\u1ecbch kh\u1edbp v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng trong huy\u1ebft t\u01b0\u01a1ng. H\u1ea7u nh\u01b0 to\u00e0n b\u1ed9 l\u01b0\u1ee3ng Meloxicam trong m\u00e1u (kho\u1ea3ng 99%) \u0111\u1ec1u li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 albumin.<\/p>\n
Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a di\u1ec5n ra h\u1ea7u nh\u01b0 ho\u00e0n to\u00e0n t\u1ea1i gan th\u00f4ng qua h\u1ec7 enzym cytochrom P450 (ch\u1ee7 y\u1ebfu l\u00e0 CYP2C9 v\u00e0 m\u1ed9t ph\u1ea7n CYP3A4). Thu\u1ed1c bi\u1ebfn \u0111\u1ed5i sinh h\u1ecdc t\u1ea1o th\u00e0nh 4 ch\u1ea5t trung gian kh\u00f4ng c\u00f2n ho\u1ea1t t\u00ednh, trong \u0111\u00f3 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 5′-carboxymeloxicam chi\u1ebfm t\u1edbi 60% li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng.<\/p>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i c\u00e2n b\u1eb1ng qua c\u1ea3 \u0111\u01b0\u1eddng n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n, ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t \u0111\u00e3 qua chuy\u1ec3n h\u00f3a (ch\u1ec9 d\u01b0\u1edbi 5% thu\u1ed1c nguy\u00ean v\u1eb9n xu\u1ea5t hi\u1ec7n trong ph\u00e2n v\u00e0 m\u1ed9t l\u01b0\u1ee3ng c\u1ef1c nh\u1ecf trong n\u01b0\u1edbc ti\u1ec3u). Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Meloxicam kh\u00e1 k\u00e9o d\u00e0i, trung b\u00ecnh t\u1eeb 13 \u0111\u1ebfn 25 gi\u1edd v\u1edbi \u0111\u1ed9 thanh th\u1ea3i huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t t\u1eeb 7 \u0111\u1ebfn 12 mL\/ph\u00fat, cho ph\u00e9p ng\u01b0\u1eddi b\u1ec7nh duy tr\u00ec ch\u1ebf \u0111\u1ed9 d\u00f9ng thu\u1ed1c 1 l\u1ea7n duy nh\u1ea5t trong ng\u00e0y.<\/p>\n
Thu\u1ed1c Zival 7.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
\u0110i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng tho\u00e1i h\u00f3a t\u1ea1i c\u00e1c kh\u1edbp<\/p>\n
Ng\u01b0\u1eddi b\u1ec7nh m\u1eafc vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/p>\n
Tr\u01b0\u1eddng h\u1ee3p vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u1edf \u0111\u1ed1i t\u01b0\u1ee3ng tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean<\/p>\n
$\"Zival$
Zival 7.5mg gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam trong tho\u00e1i ho\u00e1 kh\u1edbp, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/figcaption><\/figure>\n
Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n
Li\u1ec1u d\u00f9ng<\/h3>\n
Tho\u00e1i h\u00f3a kh\u1edbp: D\u00f9ng 1 vi\u00ean Zival m\u1ed7i ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng l\u00ean u\u1ed1ng ng\u00e0y 2 vi\u00ean khi c\u1ea7n.<\/p>\n
Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: S\u1eed d\u1ee5ng 1 vi\u00ean Zival m\u1ed7i ng\u00e0y, tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft t\u0103ng t\u1ed1i \u0111a 15 mg\/ng\u00e0y.<\/p>\n
Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u1edf thi\u1ebfu ni\u00ean: Tr\u1ebb t\u1eeb 60kg tr\u1edf l\u00ean d\u00f9ng 1 vi\u00ean Zival m\u1ed7i ng\u00e0y. Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 60 kg; li\u1ec1u tr\u00ean 7,5 mg kh\u00f4ng l\u00e0m t\u0103ng th\u00eam hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n
Ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i cao: Kh\u1edfi \u0111\u1ea7u v\u1edbi 1 vi\u00ean Zival m\u1ed7i ng\u00e0y.<\/p>\n
Suy th\u1eadn n\u1eb7ng \u0111ang l\u1ecdc m\u00e1u: Kh\u00f4ng d\u00f9ng qu\u00e1 1 vi\u00ean Zival m\u1ed7i ng\u00e0y.<\/p>\n
Thanh thi\u1ebfu ni\u00ean 12-18 tu\u1ed5i: Li\u1ec1u t\u1ed1i \u0111a 0,25 mg\/kg\/ng\u00e0y.<\/p>\n
Li\u1ec1u t\u1ed1i \u0111a: 15 mg\/ng\u00e0y, t\u00ednh tr\u00ean t\u1ed5ng l\u01b0\u1ee3ng Meloxicam t\u1eeb t\u1ea5t c\u1ea3 d\u1ea1ng b\u00e0o ch\u1ebf.<\/p>\n
C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n
Vi\u00ean n\u00e9n Zival 7.5mg<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng trong b\u1eefa \u0103n<\/p>\n
\u01afu ti\u00ean d\u00f9ng li\u1ec1u t\u1ed1i thi\u1ec3u \u0111\u1ea1t t\u00e1c d\u1ee5ng trong th\u1eddi gian ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3<\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Zival 7.5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Meloxicam hay b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Zival 7.5mg v\u1edbi Aspirin ho\u1eb7c c\u00e1c NSAID kh\u00e1c (\u0111\u1eb7c bi\u1ec7t n\u1ebfu t\u1eebng b\u1ecb hen, polyp m\u0169i, ph\u00f9 m\u1ea1ch, m\u1ec1 \u0111ay sau khi d\u00f9ng).<\/p>\n
Thai ph\u1ee5 3 th\u00e1ng cu\u1ed1i<\/p>\n
Ng\u01b0\u1eddi b\u1ecb vi\u00eam ru\u1ed9t ti\u1ebfn tri\u1ec3n (Crohn, vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng); ng\u01b0\u1eddi \u0111ang b\u1ecb ho\u1eb7c t\u1eebng b\u1ecb lo\u00e9t\/xu\u1ea5t huy\u1ebft d\u1ea1 d\u00e0y – t\u00e1 tr\u00e0ng t\u00e1i ph\u00e1t (t\u1eeb 2 \u0111\u1ee3t tr\u1edf l\u00ean); ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed th\u1ee7ng ho\u1eb7c ch\u1ea3y m\u00e1u ti\u00eau h\u00f3a do d\u00f9ng NSAID.<\/p>\n
B\u1ec7nh nh\u00e2n suy tim giai \u0111o\u1ea1n n\u1eb7ng, suy gi\u1ea3m ch\u1ee9c n\u0103ng gan tr\u1ea7m tr\u1ecdng, suy th\u1eadn n\u1eb7ng (tr\u1eeb tr\u01b0\u1eddng h\u1ee3p \u0111ang l\u1ecdc m\u00e1u).<\/p>\n
\u0110ang b\u1ecb ch\u1ea3y m\u00e1u n\u1ed9i t\u1ea1ng (ti\u00eau h\u00f3a, n\u00e3o…), ng\u01b0\u1eddi m\u1eafc ch\u1ee9ng kh\u00f3 \u0111\u00f4ng m\u00e1u v\u00e0 b\u1ec7nh nh\u00e2n v\u1eeba th\u1ef1c hi\u1ec7n ph\u1eabu thu\u1eadt b\u1eafc c\u1ea7u m\u1ea1ch v\u00e0nh (CABG).<\/p>\n
Ng\u01b0\u1eddi d\u01b0\u1edbi 16 tu\u1ed5i<\/p>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n
Th\u1eadn tr\u1ecdng<\/h3>\n
Th\u1eadn tr\u1ecdng khi d\u00f9ng meloxicam cho ng\u01b0\u1eddi cao tu\u1ed5i, th\u1ec3 tr\u1ea1ng y\u1ebfu ho\u1eb7c c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng gan, th\u1eadn, tim.<\/p>\n
Theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 l\u01b0\u1ee3ng n\u01b0\u1edbc ti\u1ec3u \u1edf ng\u01b0\u1eddi m\u1ea5t n\u01b0\u1edbc, suy tim, x\u01a1 gan, b\u1ec7nh th\u1eadn ho\u1eb7c c\u00f3 nguy c\u01a1 gi\u1ea3m t\u01b0\u1edbi m\u00e1u th\u1eadn.<\/p>\n
B\u1ec7nh nh\u00e2n suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i \u0111ang l\u1ecdc m\u00e1u kh\u00f4ng d\u00f9ng qu\u00e1 7,5 mg\/ng\u00e0y. Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf suy th\u1eadn nh\u1eb9 ho\u1eb7c trung b\u00ecnh c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin tr\u00ean 25 mL\/ph\u00fat.<\/p>\n
Theo d\u00f5i ch\u1ee9c n\u0103ng gan trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. N\u1ebfu b\u1ea5t th\u01b0\u1eddng k\u00e9o d\u00e0i ho\u1eb7c t\u0103ng \u0111\u00e1ng k\u1ec3, c\u1ea7n ng\u1eebng thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 l\u1ea1i.<\/p>\n
Meloxicam c\u00f3 th\u1ec3 che l\u1ea5p bi\u1ec3u hi\u1ec7n c\u1ee7a nhi\u1ec5m khu\u1ea9n, do \u0111\u00f3 c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng \u1edf ng\u01b0\u1eddi nghi ng\u1edd nhi\u1ec5m khu\u1ea9n.<\/p>\n
Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho ph\u1ee5 n\u1eef \u0111ang c\u00f3 \u00fd \u0111\u1ecbnh mang thai. C\u00f3 th\u1ec3 c\u00e2n nh\u1eafc ng\u1eebng thu\u1ed1c \u1edf ng\u01b0\u1eddi kh\u00f3 th\u1ee5 thai ho\u1eb7c \u0111ang \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n
N\u00ean d\u00f9ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t nh\u1eb1m h\u1ea1n ch\u1ebf nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch.<\/p>\n
Thu\u1ed1c ch\u1ee9a lactose, kh\u00f4ng ph\u00f9 h\u1ee3p v\u1edbi ng\u01b0\u1eddi kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu Lapp lactase ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose.<\/p>\n
Thu\u1ed1c ch\u1ee9a tinh b\u1ed9t m\u00ec, c\u00f3 th\u1ec3 d\u00f9ng \u1edf ng\u01b0\u1eddi m\u1eafc b\u1ec7nh celiac nh\u01b0ng kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng n\u1ebfu d\u1ecb \u1ee9ng v\u1edbi l\u00faa m\u00ec.<\/p>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n
R\u1ea5t th\u01b0\u1eddng g\u1eb7p: N\u00f4n m\u1eeda, tr\u01b0\u1edbng b\u1ee5ng, ti\u00eau ch\u1ea3y, \u0111au v\u00f9ng b\u1ee5ng, \u1ee3 h\u01a1i, bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n.<\/p>\n
Th\u01b0\u1eddng g\u1eb7p: Nh\u1ee9c \u0111\u1ea7u.<\/p>\n
\u00cdt g\u1eb7p: Ch\u00f3ng m\u1eb7t, n\u1ed5i m\u1ea9n, ph\u00f9 n\u1ec1, cao huy\u1ebft \u00e1p, vi\u00eam lo\u00e9t mi\u1ec7ng, gi\u1eef n\u01b0\u1edbc v\u00e0 mu\u1ed1i, thi\u1ebfu m\u00e1u, ng\u1ee7 g\u1eadt, xu\u1ea5t huy\u1ebft d\u1ea1 d\u00e0y – ru\u1ed9t, t\u0103ng kali m\u00e1u (d\u1eabn t\u1edbi lo\u1ea1n nh\u1ecbp tim, c\u01a1 th\u1ec3 m\u1ec7t m\u1ecfi, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c), d\u1ecb \u1ee9ng t\u1ee9c th\u00ec, cho\u00e1ng v\u00e1ng, vi\u00eam d\u1ea1 d\u00e0y, \u0111\u1ecf b\u1eebng m\u1eb7t, ng\u1ee9a da, ph\u00f9 m\u1ea1ch, ch\u1ec9 s\u1ed1 gan b\u1ea5t th\u01b0\u1eddng (t\u0103ng men gan transaminase ho\u1eb7c bilirubin), ch\u1ec9 s\u1ed1 th\u1eadn b\u1ea5t th\u01b0\u1eddng (t\u0103ng creatinin ho\u1eb7c ur\u00ea m\u00e1u).<\/p>\n
Hi\u1ebfm g\u1eb7p: Kh\u1edfi ph\u00e1t c\u01a1n hen (do d\u1ecb \u1ee9ng ch\u00e9o v\u1edbi Aspirin\/NSAID kh\u00e1c), \u00f9 tai, bi\u1ebfn \u0111\u1ed5i t\u00e2m tr\u1ea1ng v\u00e0 c\u1ea3m x\u00fac, nh\u00ecn m\u1edd, vi\u00eam th\u1ef1c qu\u1ea3n, h\u1ed9i ch\u1ee9ng Stevens-Johnson, vi\u00eam k\u1ebft m\u1ea1c, nh\u1ecbp tim nhanh, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, ho\u1ea1i t\u1eed t\u1eed \u0111\u1ed9c bi\u1ec3u b\u00ec, lo\u00e9t d\u1ea1 d\u00e0y – t\u00e1 tr\u00e0ng, vi\u00eam ru\u1ed9t gi\u00e0.<\/p>\n
R\u1ea5t hi\u1ebfm g\u1eb7p: Vi\u00eam gan, r\u00e1ch\/th\u1ee7ng ru\u1ed9t, h\u1ed3ng ban \u0111a d\u1ea1ng, suy th\u1eadn c\u1ea5p t\u00ednh (nh\u1ea5t l\u00e0 ng\u01b0\u1eddi c\u00f3 b\u1ec7nh n\u1ec1n), n\u1ed5i b\u00f3ng n\u01b0\u1edbc tr\u00ean da.<\/p>\n
Kh\u00f4ng r\u00f5 t\u1ea7n su\u1ea5t: Nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng, vi\u00eam t\u1ee5y, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng\/ph\u1ea3n v\u1ec7 nghi\u00eam tr\u1ecdng, l\u00fa l\u1eabn, m\u1ea5t nh\u1eadn th\u1ee9c kh\u00f4ng gian, bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i tim m\u1ea1ch, ch\u1ea3y m\u00e1u ho\u1eb7c th\u1ee7ng ti\u00eau h\u00f3a n\u1eb7ng c\u00f3 r\u1ee7i ro t\u1eed vong (\u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i).<\/p>\n
T\u01b0\u01a1ng t\u00e1c<\/h3>\n
Khi ph\u1ed1i h\u1ee3p Meloxicam v\u1edbi NSAID kh\u00e1c, glucocorticoid ho\u1eb7c salicylat, nguy c\u01a1 lo\u00e9t v\u00e0 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a c\u00f3 th\u1ec3 t\u0103ng do t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng. V\u00ec v\u1eady, kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c n\u00e0y. D\u00f9ng Aspirin 1000 mg x 3 l\u1ea7n\/ng\u00e0y c\u00f3 th\u1ec3 l\u00e0m AUC v\u00e0 Cmax c\u1ee7a Meloxicam t\u0103ng l\u1ea7n l\u01b0\u1ee3t kho\u1ea3ng 10% v\u00e0 24%.<\/p>\n
Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng, Heparin to\u00e0n th\u00e2n ho\u1eb7c thu\u1ed1c ti\u00eau huy\u1ebft kh\u1ed1i c\u00f9ng Meloxicam c\u00f3 th\u1ec3 khi\u1ebfn nguy c\u01a1 ch\u1ea3y m\u00e1u cao h\u01a1n. Tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c ph\u1ed1i h\u1ee3p c\u1ea7n theo d\u00f5i c\u1ea9n th\u1eadn t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng.<\/p>\n
Nguy c\u01a1 xu\u1ea5t huy\u1ebft c\u0169ng t\u0103ng khi Meloxicam \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng thu\u1ed1c ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u ho\u1eb7c SSRI do \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng ti\u1ec3u c\u1ea7u.<\/p>\n
Meloxicam c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m th\u1ea3i tr\u1eeb Lithi qua th\u1eadn, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 Lithi v\u00e0 nguy c\u01a1 \u0111\u1ed9c t\u00ednh. N\u1ebfu c\u1ea7n ph\u1ed1i h\u1ee3p, n\u00ean ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 Lithi huy\u1ebft t\u01b0\u01a1ng trong qu\u00e1 tr\u00ecnh b\u1eaft \u0111\u1ea7u, \u0111i\u1ec1u ch\u1ec9nh ho\u1eb7c ng\u1eebng Meloxicam.<\/p>\n
S\u1ef1 ph\u1ed1i h\u1ee3p v\u1edbi Methotrexat c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m \u0111\u00e0o th\u1ea3i Methotrexat qua th\u1eadn v\u00e0 khi\u1ebfn \u0111\u1ed9c t\u00ednh t\u0103ng l\u00ean. C\u1ea7n \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd \u1edf ng\u01b0\u1eddi d\u00f9ng Methotrexat tr\u00ean 15 mg\/tu\u1ea7n ho\u1eb7c c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, \u0111\u1ed3ng th\u1eddi theo d\u00f5i c\u00f4ng th\u1ee9c m\u00e1u v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn khi c\u1ea7n ph\u1ed1i h\u1ee3p.<\/p>\n
NSAID c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 c\u1ee7a d\u1ee5ng c\u1ee5 tr\u00e1nh thai \u0111\u1eb7t trong t\u1eed cung, m\u1eb7c d\u00f9 t\u01b0\u01a1ng t\u00e1c n\u00e0y hi\u1ec7n v\u1eabn c\u1ea7n \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn th\u00eam.<\/p>\n
\u1ede ng\u01b0\u1eddi b\u1ecb m\u1ea5t n\u01b0\u1edbc, vi\u1ec7c d\u00f9ng Meloxicam c\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 suy th\u1eadn c\u1ea5p. Ng\u01b0\u1eddi b\u1ec7nh n\u00ean \u0111\u01b0\u1ee3c \u0111\u1ea3m b\u1ea3o \u0111\u1ee7 d\u1ecbch v\u00e0 ki\u1ec3m tra ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb.<\/p>\n
T\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c ch\u1eb9n beta, thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, thu\u1ed1c gi\u00e3n m\u1ea1ch v\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Meloxicam. Ngo\u00e0i ra, ph\u1ed1i h\u1ee3p NSAID v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n ho\u1eb7c thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn v\u00e0 g\u00e2y suy th\u1eadn c\u1ea5p \u1edf ng\u01b0\u1eddi \u0111\u00e3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n
Cholestyramin c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn v\u1edbi Meloxicam trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, qua \u0111\u00f3 l\u00e0m thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i nhanh h\u01a1n.<\/p>\n
Khi s\u1eed d\u1ee5ng c\u00f9ng Cyclosporin, Meloxicam c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn. Do \u0111\u00f3, c\u1ea7n ki\u1ec3m tra ch\u1ee9c n\u0103ng th\u1eadn trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p.<\/p>\n
Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a Meloxicam ch\u1ee7 y\u1ebfu li\u00ean quan \u0111\u1ebfn CYP2C9 v\u00e0 m\u1ed9t ph\u1ea7n qua CYP3A4. V\u00ec v\u1eady, c\u1ea7n l\u01b0u \u00fd kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi nh\u1eefng thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c enzym n\u00e0y.<\/p>\n
Ch\u01b0a ghi nh\u1eadn t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111\u00e1ng k\u1ec3 gi\u1eefa Meloxicam v\u1edbi thu\u1ed1c kh\u00e1ng acid, Cimetidin, Digoxin ho\u1eb7c Furosemid. Tuy nhi\u00ean, kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb ho\u00e0n to\u00e0n kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n
Do ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 t\u00ednh t\u01b0\u01a1ng k\u1ef5, kh\u00f4ng n\u00ean pha tr\u1ed9n Meloxicam v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c.<\/p>\n
L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n
Thai k\u1ef3: Ph\u1ee5 n\u1eef mang thai kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng Zival. Meloxicam \u1ee9c ch\u1ebf cyclooxygenase v\u00e0 l\u00e0m gi\u1ea3m t\u1ed5ng h\u1ee3p prostaglandin, t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i \u0111\u1ebfn thai nhi, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng v\u1edbi li\u1ec1u cao ho\u1eb7c trong th\u1eddi gian d\u00e0i. Trong giai \u0111o\u1ea1n \u0111\u1ea7u thai k\u1ef3, thu\u1ed1c c\u00f3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 s\u1ea3y thai v\u00e0 m\u1ed9t s\u1ed1 d\u1ecb t\u1eadt b\u1ea9m sinh. T\u1eeb 3 th\u00e1ng cu\u1ed1i, Meloxicam c\u00f3 th\u1ec3 g\u00e2y \u0111\u00f3ng s\u1edbm \u1ed1ng \u0111\u1ed9ng m\u1ea1ch, t\u0103ng \u00e1p l\u1ef1c m\u1ea1ch ph\u1ed5i, suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn \u1edf thai nhi, k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u v\u00e0 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh chuy\u1ec3n d\u1ea1.<\/p>\n
Kh\u1ea3 n\u0103ng sinh s\u1ea3n: Meloxicam c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh r\u1ee5ng tr\u1ee9ng v\u00e0 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng th\u1ee5 thai \u1edf ph\u1ee5 n\u1eef. V\u00ec v\u1eady, ph\u1ee5 n\u1eef \u0111ang d\u1ef1 \u0111\u1ecbnh mang thai n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p g\u1eb7p kh\u00f3 kh\u0103n khi th\u1ee5 thai ho\u1eb7c \u0111ang \u0111\u01b0\u1ee3c th\u0103m d\u00f2 nguy\u00ean nh\u00e2n v\u00f4 sinh, c\u1ea7n c\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng Meloxicam.<\/p>\n
Cho con b\u00fa: Kh\u00f4ng c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Meloxicam \u1edf ph\u1ee5 n\u1eef \u0111ang nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9. Tuy nhi\u00ean, nh\u00f3m NSAID c\u00f3 kh\u1ea3 n\u0103ng \u0111i v\u00e0o s\u1eefa m\u1eb9 n\u00ean v\u1eabn ti\u1ec1m \u1ea9n nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb. Do \u0111\u00f3, kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c khi cho con b\u00fa; n\u1ebfu c\u1ea7n \u0111i\u1ec1u tr\u1ecb, n\u00ean c\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng cho tr\u1ebb b\u00fa.<\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n
M\u1eb7c d\u00f9 ch\u01b0a c\u00f3 d\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m c\u1ee5 th\u1ec3 v\u1ec1 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, b\u1ec7nh nh\u00e2n v\u1eabn c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi tham gia c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y. Nguy\u00ean nh\u00e2n l\u00e0 do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 ch\u00f3ng m\u1eb7t, xay x\u1ea9m, bu\u1ed3n ng\u1ee7, ho\u1eb7c c\u00e1c r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c (\u0111i\u1ec3n h\u00ecnh l\u00e0 nh\u00ecn m\u1edd).

Zival 7.5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\nTh\u00e0nh ph\u1ea7n<\/h3>\nTrong m\u1ed7i vi\u00ean Zival 7.5mg<\/b> c\u00f3 ch\u1ee9a:<\/p>\n

Th\u00e0nh ph\u1ea7n<\/h3>\nTrong m\u1ed7i vi\u00ean Zival 7.5mg<\/b> c\u00f3 ch\u1ee9a:<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\nS\u0110K: 893110086224 (S\u0110K c\u0169 VD-30722-18)<\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/p>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\nH\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zival 7.5mg<\/h2>\n

Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n

Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: 893110086224 (S\u0110K c\u0169 VD-30722-18)<\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/p>\n
Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n
H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n