{"id":162137,"date":"2026-09-03T16:48:00","date_gmt":"2026-09-03T09:48:00","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=162137"},"modified":"2026-09-03T22:43:33","modified_gmt":"2026-09-03T15:43:33","slug":"zydnoz-125","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/zydnoz-125\/","title":{"rendered":"Zydnoz 125"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Zydnoz 125 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m v\u00e0 Sinh h\u1ecdc Y t\u1ebf c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-36236-22<\/b><\/p>\n<h2>Zydnoz 125 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i 5ml <strong>h\u1ed7n d\u1ecbch Zydnoz 125<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Cefprozil (d\u01b0\u1edbi d\u1ea1ng Cefprozil monohydrat): 125mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: B\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-36236-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 chai ch\u1ee9a b\u1ed9t pha 50ml h\u1ed7n d\u1ecbch<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zydnoz 125<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Cefprozil thu\u1ed9c nh\u00f3m cephalosporin b\u00e1n t\u1ed5ng h\u1ee3p, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng l\u00ean nhi\u1ec1u ch\u1ee7ng vi khu\u1ea9n Gram d\u01b0\u01a1ng c\u0169ng nh\u01b0 Gram \u00e2m. T\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c t\u1ea1o ra nh\u1edd ng\u0103n c\u1ea3n qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea9n, t\u1eeb \u0111\u00f3 d\u1eabn \u0111\u1ebfn t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Cefprozil \u0111\u01b0\u1ee3c h\u1ea5p thu kh\u00e1 t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, v\u1edbi kho\u1ea3ng 95% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c h\u1ea5p thu khi u\u1ed1ng l\u00fac \u0111\u00f3i. Sau khi s\u1eed d\u1ee5ng li\u1ec1u 250 mg, 500 mg v\u00e0 1 g, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c cao nh\u1ea5t trong huy\u1ebft t\u01b0\u01a1ng l\u1ea7n l\u01b0\u1ee3t \u0111\u1ea1t kho\u1ea3ng 6,1; 10,5 v\u00e0 18,3 mcg\/L, th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n trong kho\u1ea3ng 1,5 gi\u1edd.<\/p>\n<p>Th\u1ee9c \u0103n kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a cefprozil d\u1ea1ng h\u1ed7n d\u1ecbch, th\u1ec3 hi\u1ec7n qua AUC v\u00e0 Cmax kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng. Tuy nhi\u00ean, khi d\u00f9ng c\u00f9ng th\u1ee9c \u0103n, th\u1eddi \u0111i\u1ec3m \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh (Tmax) c\u00f3 th\u1ec3 ch\u1eadm h\u01a1n kho\u1ea3ng 0,25-0,75 gi\u1edd.<\/p>\n<p>Kho\u1ea3ng 36% cefprozil trong huy\u1ebft t\u01b0\u01a1ng g\u1eafn v\u1edbi protein, t\u1ef7 l\u1ec7 n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng khi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c n\u1eb1m trong kho\u1ea3ng 2-20 mcg\/mL. \u1ede ng\u01b0\u1eddi c\u00f3 ch\u1ee9c n\u0103ng sinh l\u00fd b\u00ecnh th\u01b0\u1eddng, thu\u1ed1c c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh kho\u1ea3ng 1,3 gi\u1edd v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh kho\u1ea3ng 0,23 L\/kg.<\/p>\n<p>Thu\u1ed1c xu\u1ea5t th\u1ea3i qua \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, chi\u1ebfm x\u1ea5p x\u1ec9 60% t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c \u0111\u00e3 d\u00f9ng. V\u1ec1 kh\u1ea3 n\u0103ng thanh th\u1ea3i, \u0111\u1ed9 thanh th\u1ea3i to\u00e0n th\u00e2n \u0111\u1ea1t kho\u1ea3ng 3 mL\/ph\u00fat\/kg, trong khi \u0111\u1ed9 thanh th\u1ea3i t\u1ea1i th\u1eadn kho\u1ea3ng 2,3 mL\/ph\u00fat\/kg.<\/p>\n<h2>Thu\u1ed1c Zydnoz 125 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>D\u1ea1ng b\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng cefprozil chuy\u00ean d\u00f9ng \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh do nh\u1eefng ch\u1ee7ng nh\u1ea1y c\u1ea3m sau:<\/p>\n<ul>\n<li>H\u00f4 h\u1ea5p tr\u00ean: Vi\u00eam h\u1ecdng\/vi\u00eam amidan (do <i>S. pyogenes<\/i>); Vi\u00eam tai gi\u1eefa c\u1ea5p v\u00e0 Vi\u00eam xoang c\u1ea5p (do <i>S. pneumoniae<\/i>, <i>H. influenzae<\/i>, <i>M. catarrhalis<\/i> &#8211; g\u1ed3m c\u1ea3 ch\u1ee7ng ti\u1ebft beta-lactamase).<\/li>\n<li>H\u00f4 h\u1ea5p d\u01b0\u1edbi: \u0110\u1ee3t c\u1ea5p c\u1ee7a vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n (do <i>S. pneumoniae<\/i>, <i>H. influenzae<\/i>, <i>M. catarrhalis<\/i> &#8211; g\u1ed3m c\u1ea3 ch\u1ee7ng ti\u1ebft beta-lactamase).<\/li>\n<li>Da v\u00e0 t\u1ed5 ch\u1ee9c d\u01b0\u1edbi da: Nhi\u1ec5m khu\u1ea9n ch\u01b0a bi\u1ebfn ch\u1ee9ng (do <i>S. aureus<\/i> ti\u1ebft\/kh\u00f4ng ti\u1ebft beta-lactamase v\u00e0 <i>S. pyogenes<\/i>). Tr\u01b0\u1eddng h\u1ee3p c\u00f3 \u1ed5 \u00e1p-xe, c\u1ea7n ph\u1ed1i h\u1ee3p can thi\u1ec7p ngo\u1ea1i khoa \u0111\u1ec3 d\u1eabn l\u01b0u.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/To-huong-dan-su-dung-Zydnoz-125-vnras.pdf\">To-huong-dan-su-dung-Zydnoz-125-vnras<\/a><\/p>\n<figure id=\"attachment_162320\" aria-describedby=\"caption-attachment-162320\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-162320\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125.jpg\" alt=\"Zydnoz 125 \" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/Zydnoz-125-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-162320\" class=\"wp-caption-text\">Zydnoz 125 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><strong>Li\u1ec1u d\u00f9ng theo \u0111\u1ed9 tu\u1ed5i &amp; b\u1ec7nh l\u00fd <\/strong><i>(\u0110\u1ec1u \u0111i\u1ec1u tr\u1ecb trong 10 ng\u00e0y)<\/i><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb \u2265 13 tu\u1ed5i:<\/p>\n<ul>\n<li><i>Vi\u00eam h\u1ecdng\/amidan:<\/i> 500mg\/24 gi\u1edd.<\/li>\n<li><i>Vi\u00eam xoang c\u1ea5p, vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n (\u0111\u1ee3t c\u1ea5p) &amp; Nhi\u1ec5m khu\u1ea9n da:<\/i> 250mg &#8211; 500mg m\u1ed7i 12 gi\u1edd (ho\u1eb7c 500mg\/24 gi\u1edd \u0111\u1ed1i v\u1edbi da).<\/li>\n<\/ul>\n<p>Tr\u1ebb em (6 th\u00e1ng &#8211; 12 tu\u1ed5i):<\/p>\n<ul>\n<li><i>Vi\u00eam h\u1ecdng\/amidan &amp; Vi\u00eam xoang c\u1ea5p:<\/i> 7,5mg\/kg m\u1ed7i 12 gi\u1edd (vi\u00eam xoang n\u1eb7ng t\u0103ng l\u00ean 15mg\/kg m\u1ed7i 12 gi\u1edd).<\/li>\n<li><i>Vi\u00eam tai gi\u1eefa (tr\u1ebb 6 th\u00e1ng &#8211; 12 tu\u1ed5i):<\/i> 15mg\/kg m\u1ed7i 12 gi\u1edd.<\/li>\n<li><i>Nhi\u1ec5m khu\u1ea9n da (tr\u1ebb 2 &#8211; 12 tu\u1ed5i):<\/i> 20mg\/kg m\u1ed7i 24 gi\u1edd.<\/li>\n<\/ul>\n<p><i>L\u01b0u \u00fd:<\/i> Tr\u1ebb em kh\u00f4ng u\u1ed1ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u t\u1ed1i \u0111a c\u1ee7a ng\u01b0\u1eddi l\u1edbn. Tr\u1eeb tr\u01b0\u1eddng h\u1ee3p do <i>Streptococcus pyogenes<\/i> b\u1eaft bu\u1ed9c d\u00f9ng t\u1ed1i thi\u1ec3u 10 ng\u00e0y, c\u00e1c ch\u1ec9 \u0111\u1ecbnh tr\u00ean \u0111\u1ec1u \u00e1p d\u1ee5ng li\u1ec7u tr\u00ecnh 10 ng\u00e0y.<\/p>\n<p><strong>B\u1ec7nh nh\u00e2n suy th\u1eadn &amp; suy gan<\/strong><\/p>\n<ul>\n<li>Suy th\u1eadn: \u0110\u1ed9 thanh th\u1ea3i creatinin t\u1eeb 30 &#8211; 120 mL\/ph\u00fat d\u00f9ng li\u1ec1u ti\u00eau chu\u1ea9n. Khi \u0111\u1ed9 thanh th\u1ea3i &lt; 30 mL\/ph\u00fat, gi\u1ea3m 1\/2 li\u1ec1u v\u00e0 gi\u1eef nguy\u00ean kho\u1ea3ng c\u00e1ch \u0111\u01b0a thu\u1ed1c. C\u1ea7n u\u1ed1ng thu\u1ed1c sau khi k\u1ebft th\u00fac th\u1ea9m t\u00e1ch m\u00e1u.<\/li>\n<li>Suy gan: D\u00f9ng li\u1ec1u Zydnoz b\u00ecnh th\u01b0\u1eddng, kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Th\u00eam n\u01b0\u1edbc s\u1ea1ch ch\u00ednh x\u00e1c t\u1edbi m\u1ed1c v\u1ea1ch quy \u0111\u1ecbnh tr\u00ean v\u1ecf chai, sau \u0111\u00f3 l\u1eafc \u0111\u1ec1u r\u1ed3i u\u1ed1ng<\/p>\n<p>B\u1ea3o qu\u1ea3n h\u1ed7n d\u1ecbch \u0111\u00e3 pha trong t\u1ee7 l\u1ea1nh, duy tr\u00ec \u1edf m\u1ee9c 2-8\u00b0C. Ph\u1ea7n thu\u1ed1c sau khi pha c\u1ea7n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u1ebft trong 14 ng\u00e0y. Nh\u01b0ng m\u1ed7i l\u1ea7n l\u1ea5y thu\u1ed1c ph\u1ea3i l\u1eafc chai th\u1eadt k\u1ef9 tr\u01b0\u1edbc khi u\u1ed1ng<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Zydnoz 125 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Cefprozil ho\u1eb7c t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Zydnoz 125 ho\u1eb7c kh\u00e1ng sinh nh\u00f3m cephalosporin<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Tr\u01b0\u1edbc khi d\u00f9ng cefprozil, c\u1ea7n ki\u1ec3m tra ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh v\u1edbi cefprozil, c\u00e1c thu\u1ed1c cephalosporin, penicillin ho\u1eb7c nh\u1eefng thu\u1ed1c kh\u00e1c. Ng\u01b0\u1eddi t\u1eebng d\u1ecb \u1ee9ng penicillin n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thu\u1ed1c m\u1ed9t c\u00e1ch th\u1eadn tr\u1ecdng do c\u00f3 th\u1ec3 x\u1ea3y ra ph\u1ea3n \u1ee9ng m\u1eabn c\u1ea3m ch\u00e9o gi\u1eefa c\u00e1c kh\u00e1ng sinh beta-lactam.<\/p>\n<p>Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i s\u00e1t v\u00e0 c\u00e2n nh\u1eafc \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u. Nguy\u00ean nh\u00e2n l\u00e0 cefprozil c\u00f3 th\u1ec3 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 cao h\u01a1n ho\u1eb7c l\u01b0u l\u1ea1i l\u00e2u h\u01a1n trong c\u01a1 th\u1ec3 khi ch\u1ee9c n\u0103ng th\u1eadn b\u1ecb suy gi\u1ea3m.<\/p>\n<p>Cefprozil ch\u1ec9 n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng khi c\u00f3 nhi\u1ec5m khu\u1ea9n ho\u1eb7c ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng r\u00f5 r\u00e0ng. Vi\u1ec7c d\u00f9ng kh\u00e1ng sinh kh\u00f4ng c\u1ea7n thi\u1ebft c\u00f3 th\u1ec3 l\u00e0m gia t\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n vi khu\u1ea9n kh\u00e1ng thu\u1ed1c.<\/p>\n<p>N\u1ebfu ph\u1ea3i \u0111i\u1ec1u tr\u1ecb trong th\u1eddi gian d\u00e0i, c\u1ea7n theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho c\u00e1c vi sinh v\u1eadt kh\u00f4ng nh\u1ea1y c\u1ea3m ph\u00e1t tri\u1ec3n. Khi xu\u1ea5t hi\u1ec7n b\u1ed9i nhi\u1ec5m, c\u1ea7n \u0111\u00e1nh gi\u00e1 v\u00e0 x\u1eed tr\u00ed ph\u00f9 h\u1ee3p.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed m\u1eafc b\u1ec7nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1eb7c bi\u1ec7t l\u00e0 vi\u00eam \u0111\u1ea1i tr\u00e0ng, c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u1ef9 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng cefprozil.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Ph\u1ea7n l\u1edbn ng\u01b0\u1eddi b\u1ec7nh dung n\u1ea1p cefprozil t\u1ed1t v\u00e0 ch\u1ec9 kho\u1ea3ng 2% tr\u01b0\u1eddng h\u1ee3p ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb do ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i. Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng, c\u00e1c bi\u1ec3u hi\u1ec7n th\u01b0\u1eddng \u0111\u01b0\u1ee3c ghi nh\u1eadn g\u1ed3m bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, n\u00f4n, \u0111au b\u1ee5ng; trong \u0111\u00f3 bu\u1ed3n n\u00f4n v\u00e0 ti\u00eau ch\u1ea3y c\u00f3 t\u1ef7 l\u1ec7 l\u1ea7n l\u01b0\u1ee3t kho\u1ea3ng 3,5% v\u00e0 2,9%.<\/p>\n<p>M\u1ed9t s\u1ed1 thay \u0111\u1ed5i x\u00e9t nghi\u1ec7m c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, \u0111i\u1ec3n h\u00ecnh l\u00e0 t\u0103ng AST ho\u1eb7c ALT kho\u1ea3ng 2%, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan 2,3% v\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u 0,2%. Ph\u00e1t ban v\u00e0 m\u00e0y \u0111ay c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra, v\u1edbi t\u1ef7 l\u1ec7 t\u01b0\u01a1ng \u1ee9ng 0,9% v\u00e0 0,1%, th\u01b0\u1eddng g\u1eb7p \u1edf tr\u1ebb em h\u01a1n ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>C\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, bu\u1ed3n ng\u1ee7 ho\u1eb7c l\u00fa l\u1eabn \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o v\u1edbi t\u1ea7n su\u1ea5t d\u01b0\u1edbi 1% v\u00e0 th\u01b0\u1eddng h\u1ed3i ph\u1ee5c khi ng\u1eebng thu\u1ed1c. Cefprozil c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u1eb9 BUN ho\u1eb7c creatinin huy\u1ebft thanh.<\/p>\n<p>Trong giai \u0111o\u1ea1n h\u1eadu m\u00e3i, m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0ng r\u1ea5t hi\u1ebfm \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn, bao g\u1ed3m ph\u1ea3n v\u1ec7, ph\u00f9 m\u1ea1ch, vi\u00eam \u0111\u1ea1i tr\u00e0ng, h\u1ed9i ch\u1ee9ng Stevens-Johnson v\u00e0 gi\u1ea3m ti\u1ec3u c\u1ea7u. V\u1edbi nh\u00f3m cephalosporin, nguy c\u01a1 co gi\u1eadt c\u1ea7n \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd \u1edf ng\u01b0\u1eddi suy th\u1eadn n\u1ebfu li\u1ec1u d\u00f9ng kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh ph\u00f9 h\u1ee3p; khi xu\u1ea5t hi\u1ec7n co gi\u1eadt li\u00ean quan \u0111\u1ebfn thu\u1ed1c, c\u1ea7n ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u00e0 x\u1eed tr\u00ed theo t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Cefprozil c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i t\u00e1c \u0111\u1ed9ng c\u1ee7a m\u1ed9t s\u1ed1 thu\u1ed1c d\u00f9ng \u0111\u1ed3ng th\u1eddi. \u0110\u00e1ng l\u01b0u \u00fd, ph\u1ed1i h\u1ee3p v\u1edbi probenecid khi\u1ebfn m\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m cefprozil t\u0103ng l\u00ean, th\u1ec3 hi\u1ec7n qua AUC t\u0103ng kho\u1ea3ng 2 l\u1ea7n. Khi d\u00f9ng chung v\u1edbi kh\u00e1ng sinh aminoglycosid, c\u1ea7n ch\u00fa \u00fd \u0111\u1ebfn nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i tr\u00ean th\u1eadn. Ng\u01b0\u1ee3c l\u1ea1i, vi\u1ec7c u\u1ed1ng cefprozil d\u1ea1ng vi\u00ean nang kho\u1ea3ng 5 ph\u00fat sau thu\u1ed1c kh\u00e1ng acid kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu.<\/p>\n<p>Ngo\u00e0i t\u01b0\u01a1ng t\u00e1c thu\u1ed1c, cefprozil c\u00f2n c\u1ea7n \u0111\u01b0\u1ee3c l\u01b0u \u00fd khi th\u1ef1c hi\u1ec7n m\u1ed9t s\u1ed1 x\u00e9t nghi\u1ec7m. K\u1ebft qu\u1ea3 glucose ni\u1ec7u c\u00f3 th\u1ec3 d\u01b0\u01a1ng t\u00ednh gi\u1ea3 n\u1ebfu s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p kh\u1eed \u0111\u1ed3ng, trong khi ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh l\u01b0\u1ee3ng b\u1eb1ng enzym kh\u00f4ng g\u1eb7p \u1ea3nh h\u01b0\u1edfng n\u00e0y. X\u00e9t nghi\u1ec7m glucose m\u00e1u b\u1eb1ng ferricyanid c\u00f3 kh\u1ea3 n\u0103ng cho k\u1ebft qu\u1ea3 \u00e2m t\u00ednh gi\u1ea3. Tuy nhi\u00ean, cefprozil kh\u00f4ng l\u00e0m sai l\u1ec7ch k\u1ebft qu\u1ea3 \u0111\u1ecbnh l\u01b0\u1ee3ng creatinin huy\u1ebft t\u01b0\u01a1ng v\u00e0 creatinin n\u01b0\u1edbc ti\u1ec3u b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p picrat ki\u1ec1m.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u00e2n lo\u1ea1i Thai k\u1ef3: Nh\u00f3m B. Ch\u01b0a ph\u00e1t hi\u1ec7n nguy c\u01a1 g\u00e2y qu\u00e1i thai hay \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn thai nhi trong c\u00e1c kh\u1ea3o s\u00e1t tr\u00ean \u0111\u1ed9ng v\u1eadt (th\u1ecf, chu\u1ed9t) \u1edf li\u1ec1u d\u00f9ng g\u1ea5p t\u1eeb 0,8 \u0111\u1ebfn 18,5 l\u1ea7n li\u1ec1u t\u1ed1i \u0111a khuy\u1ebfn c\u00e1o \u1edf ng\u01b0\u1eddi (1000mg\/ng\u00e0y). Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u ki\u1ec3m so\u00e1t nghi\u00eam ng\u1eb7t tr\u00ean ph\u1ee5 n\u1eef mang thai. V\u00ec ph\u1ea3n \u1ee9ng tr\u00ean ng\u01b0\u1eddi c\u00f3 th\u1ec3 kh\u00e1c v\u1edbi th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt, k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng th\u1ec3 \u0111\u1ea1i di\u1ec7n ho\u00e0n to\u00e0n cho con ng\u01b0\u1eddi, cefprozil ch\u1ec9 n\u00ean ch\u1ec9 \u0111\u1ecbnh cho \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p>Cefprozil c\u00f3 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 \u1edf m\u1ee9c r\u1ea5t th\u1ea5p, v\u1edbi l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c ghi nh\u1eadn d\u01b0\u1edbi 0,3% li\u1ec1u s\u1eed d\u1ee5ng sau khi d\u00f9ng li\u1ec1u gram \u1edf ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong s\u1eefa, t\u00ednh trung b\u00ecnh trong 24 gi\u1edd, n\u1eb1m trong kho\u1ea3ng 0,25-3,3 mcg\/mL. Do hi\u1ec7n ch\u01b0a c\u00f3 \u0111\u1ee7 th\u00f4ng tin v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a cefprozil \u0111\u1ed1i v\u1edbi tr\u1ebb b\u00fa m\u1eb9, c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 c\u00e2n nh\u1eafc k\u1ef9 tr\u01b0\u1edbc khi ch\u1ec9 \u0111\u1ecbnh cefprozil cho ph\u1ee5 n\u1eef \u0111ang trong giai \u0111o\u1ea1n cho con b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm g\u1eb7p, thu\u1ed1c c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, g\u00e2y r\u1ed1i lo\u1ea1n tr\u1ea1ng th\u00e1i t\u1ec9nh t\u00e1o, thay \u0111\u1ed5i t\u00e2m l\u00fd ho\u1eb7c gi\u1ea5c ng\u1ee7 v\u00e0 c\u1ea3m gi\u00e1c \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t. C\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n ch\u00fa \u00fd an to\u00e0n khi l\u00e1i xe, thao t\u00e1c m\u00e1y m\u00f3c ho\u1eb7c th\u1ef1c hi\u1ec7n c\u00e1c c\u00f4ng vi\u1ec7c \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1eadp trung.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>D\u1eef li\u1ec7u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y cefprozil c\u00f3 m\u1ee9c \u0111\u1ed9 an to\u00e0n t\u01b0\u01a1ng \u0111\u1ed1i cao khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng. \u1ede chu\u1ed9t, li\u1ec1u \u0111\u01a1n 5.000 mg\/kg kh\u00f4ng ghi nh\u1eadn t\u1eed vong hay bi\u1ec3u hi\u1ec7n \u0111\u1ed9c t\u00ednh, trong khi kh\u1ec9 cynomolgus \u0111\u01b0\u1ee3c d\u00f9ng 3.000 mg\/kg c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ti\u00eau ch\u1ea3y v\u00e0 gi\u1ea3m \u0103n nh\u01b0ng kh\u00f4ng d\u1eabn \u0111\u1ebfn t\u1eed vong.<\/p>\n<p>Do thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn, ng\u01b0\u1eddi b\u1ec7nh b\u1ecb qu\u00e1 li\u1ec1u nghi\u00eam tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t khi ch\u1ee9c n\u0103ng th\u1eadn suy gi\u1ea3m, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u1ecdc m\u00e1u \u0111\u1ec3 h\u1ed7 tr\u1ee3 lo\u1ea1i cefprozil kh\u1ecfi c\u01a1 th\u1ec3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef <strong>Zydnoz 125<\/strong> \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Zydnoz 125 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Zydnoz 125 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Zydnoz 125 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Zydnoz 125 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Zydnoz 125 c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Zydnoz 125 t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Zydnoz 125 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/sabrof-125\/\">Sabrof 125 <\/a>c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Cefprozil 125mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m H\u00e0 T\u00e2y, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/cerepone-125mg\/\">Cerepone 125mg <\/a>c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Cefprozil 125mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m Kolmar Kore, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Zydnoz 125 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/09\/To-huong-dan-su-dung-Zydnoz-125-vnras.pdf\">t\u1ea1i \u0111\u00e2y.<\/a> Truy c\u1eadp ng\u00e0y 3 th\u00e1ng 9 n\u0103m 2026<\/li>\n<li>Wiseman LR, Benfield P. Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential. Drugs. Truy c\u1eadp ng\u00e0y 3 th\u00e1ng 9 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7681376\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/7681376\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Zydnoz 125 ch\u1ee9a cefprozil 125 mg m\u1ed7i 5 mL h\u1ed7n d\u1ecbch, thu\u1ed9c nh\u00f3m kh\u00e1ng sinh cephalosporin, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra.<\/p>\n","protected":false},"author":1,"featured_media":162313,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-162137","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/162137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=162137"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/162313"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=162137"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=162137"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=162137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}