{"id":160424,"date":"2026-07-18T14:50:03","date_gmt":"2026-07-18T07:50:03","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=160424"},"modified":"2026-07-18T14:51:15","modified_gmt":"2026-07-18T07:51:15","slug":"taf-5a","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/taf-5a\/","title":{"rendered":"TAF-5A"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c TAF-5A \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n li\u00ean doanh D\u01b0\u1ee3c ph\u1ea9m \u00c9loge France Vi\u1ec7t Nam c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110086000<\/b><\/p>\n<h2>TAF-5A l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i vi\u00ean <b>TAF-5A<\/b> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Tenofovir alafenamid: 25mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110086000<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c TAF-5A<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Sau khi \u0111\u01b0\u1ee3c h\u1ea5p thu, tenofovir alafenamid ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ti\u1ec1n ch\u1ea5t gi\u00fap \u0111\u01b0a tenofovir v\u00e0o t\u1ebf b\u00e0o gan hi\u1ec7u qu\u1ea3 h\u01a1n. T\u1ea1i \u0111\u00e2y, d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a enzym carboxylesterase-1, thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh tenofovir r\u1ed3i ti\u1ebfp t\u1ee5c phosphoryl h\u00f3a th\u00e0nh tenofovir diphosphat \u2013 d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh. Ch\u1ea5t n\u00e0y c\u1ea1nh tranh v\u1edbi nucleotide t\u1ef1 nhi\u00ean trong qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p ADN c\u1ee7a virus vi\u00eam gan B, l\u00e0m ng\u1eebng k\u00e9o d\u00e0i chu\u1ed7i ADN v\u00e0 t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a HBV. Tenofovir c\u00f2n c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ed1i v\u1edbi HIV-1 v\u00e0 HIV-2. M\u1eb7c d\u00f9 c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng l\u00ean ADN polymerase c\u1ee7a t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa, tenofovir diphosphat ch\u1ec9 \u1ee9c ch\u1ebf enzym n\u00e0y \u1edf m\u1ee9c r\u1ea5t th\u1ea5p v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u in vitro ch\u01b0a ghi nh\u1eadn d\u1ea5u hi\u1ec7u g\u00e2y \u0111\u1ed9c tr\u00ean ty th\u1ec3.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>\u1ede ng\u01b0\u1eddi l\u1edbn b\u1ecb vi\u00eam gan B m\u00e3n t\u00ednh, tenofovir alafenamid u\u1ed1ng l\u00fac \u0111\u00f3i \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau g\u1ea7n 0,48 gi\u1edd. Theo d\u1eef li\u1ec7u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc qu\u1ea7n th\u1ec3 pha III, c\u00e1c ch\u1ec9 s\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u1ee7a tenofovir alafenamid v\u00e0 tenofovir l\u1ea7n l\u01b0\u1ee3t l\u00e0: AUC\u2080\u208b\u2082\u2084 trung b\u00ecnh \u0111\u1ea1t 0,22 \u00b5g\u00b7h\/mL v\u00e0 0,32 \u00b5g\u00b7h\/mL; Cmax \u0111\u1ea1t 0,18 \u00b5g\/mL v\u00e0 0,02 \u00b5g\/mL. Ngo\u00e0i ra, vi\u1ec7c d\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t c\u00f9ng th\u1ee9c \u0103n gi\u00e0u ch\u1ea5t b\u00e9o s\u1ebd khi\u1ebfn h\u00e0m l\u01b0\u1ee3ng tenofovir alafenamid t\u0103ng th\u00eam 65%.<\/p>\n<p>T\u1ef7 l\u1ec7 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a tenofovir alafenamid \u0111\u1ea1t x\u1ea5p x\u1ec9 80%. Ng\u01b0\u1ee3c l\u1ea1i, \u0111\u1ed1i v\u1edbi tenofovir, t\u1ef7 l\u1ec7 li\u00ean k\u1ebft n\u00e0y c\u1ef1c k\u1ef3 th\u1ea5p khi ch\u01b0a t\u1edbi 0,7% v\u00e0 ho\u00e0n to\u00e0n c\u1ed1 \u0111\u1ecbnh, kh\u00f4ng b\u1ecb bi\u1ebfn \u0111\u1ed9ng theo h\u00e0m l\u01b0\u1ee3ng thu\u1ed1c trong ph\u1ea1m vi t\u1eeb 0,01 \u0111\u1ebfn 25 \u00b5g\/mL.<\/p>\n<p>Th\u1eed nghi\u1ec7m <i>in vitro<\/i> cho th\u1ea5y ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n th\u00e0nh tenofovir (d\u1ea1ng chuy\u1ec3n h\u00f3a c\u1ed1t l\u00f5i) nh\u1edd enzyme carboxylesterase-1 t\u1ea1i gan, ho\u1eb7c nh\u1edd cathepsin A t\u1ea1i c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o v\u00e0 t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n m\u00e1u ngo\u1ea1i vi (PBMC). Qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i n\u1ed9i b\u00e0o <i>in vivo<\/i> c\u0169ng t\u1ea1o ra tenofovir tr\u01b0\u1edbc khi ti\u1ebfp t\u1ee5c phosphoryl h\u00f3a th\u00e0nh d\u1ea1ng ho\u1ea1t t\u00ednh tenofovir diphosphate. \u0110\u1ed1i v\u1edbi h\u1ec7 enzyme gan, tenofovir alafenamid kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a b\u1edfi c\u00e1c CYP v\u00e0 ch\u1ec9 b\u1ecb chuy\u1ec3n h\u00f3a m\u1ed9t ph\u1ea7n r\u1ea5t nh\u1ecf qua CYP3A4.<\/p>\n<p>Th\u1eadn ch\u1ec9 \u0111\u00e0o th\u1ea3i m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf tenofovir alafenamid \u1edf d\u1ea1ng ch\u01b0a bi\u1ebfn \u0111\u1ed5i, chi\u1ebfm ch\u01b0a \u0111\u1ea7y 1% li\u1ec1u s\u1eed d\u1ee5ng trong n\u01b0\u1edbc ti\u1ec3u, do thu\u1ed1c ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft sau khi \u0111\u00e3 chuy\u1ec3n h\u00f3a th\u00e0nh tenofovir. Trong huy\u1ebft t\u01b0\u01a1ng, th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a tenofovir alafenamid v\u00e0 tenofovir l\u1ea7n l\u01b0\u1ee3t l\u00e0 0,51 gi\u1edd v\u00e0 32,37 gi\u1edd. \u0110\u1ed1i v\u1edbi tenofovir, ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua \u0111\u01b0\u1eddng th\u1eadn th\u00f4ng qua s\u1ef1 ph\u1ed1i h\u1ee3p gi\u1eefa l\u1ecdc t\u1ea1i c\u1ea7u th\u1eadn v\u00e0 b\u00e0i ti\u1ebft ch\u1ee7 \u0111\u1ed9ng t\u1ea1i \u1ed1ng th\u1eadn.<\/p>\n<h2>Thu\u1ed1c TAF-5A \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n vi\u00eam gan B m\u1ea1n t\u00ednh l\u00e0 ng\u01b0\u1eddi l\u1edbn ho\u1eb7c thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 c\u00f3 c\u00e2n n\u1eb7ng \u0111\u1ea1t t\u1eeb 35 kg tr\u1edf l\u00ean.<\/p>\n<figure id=\"attachment_160433\" aria-describedby=\"caption-attachment-160433\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-160433\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A.jpg\" alt=\"TAF-5A\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/TAF-5A-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-160433\" class=\"wp-caption-text\">Thu\u1ed1c TAF-5A c\u00f3 t\u00e1c d\u1ee5ng g\u00ec trong \u0111i\u1ec1u tr\u1ecb vi\u00eam gan B m\u1ea1n t\u00ednh<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>1 vi\u00ean\/ng\u00e0y<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>D\u00f9ng <strong>vi\u00ean n\u00e9n TAF-5A<\/strong> b\u1eb1ng \u0111\u01b0\u1ee3c u\u1ed1ng v\u1edbi n\u01b0\u1edbc l\u1ecdc c\u00f9ng b\u1eefa \u0103n<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c TAF-5A trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi tenofovir alafenamid ho\u1eb7c t\u00e1 d\u01b0\u1ee3c c\u00f3 trong<strong> TAF-5A<\/strong><\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Thu\u1ed1c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u00f2ng ng\u1eeba l\u00e2y nhi\u1ec5m HBV, v\u00ec v\u1eady ng\u01b0\u1eddi b\u1ec7nh v\u1eabn c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p b\u1ea3o v\u1ec7 khi quan h\u1ec7 t\u00ecnh d\u1ee5c v\u00e0 tr\u00e1nh ti\u1ebfp x\u00fac v\u1edbi m\u00e1u.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 x\u01a1 gan ho\u1eb7c b\u1ec7nh gan ti\u1ebfn tri\u1ec3n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd ch\u1ee9c n\u0103ng gan trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb v\u00e0 sau khi ng\u1eebng thu\u1ed1c.<\/p>\n<p>Vi\u1ec7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 l\u00e0m vi\u00eam gan B t\u00e1i b\u00f9ng ph\u00e1t, do \u0111\u00f3 c\u1ea7n theo d\u00f5i l\u00e2m s\u00e0ng v\u00e0 x\u00e9t nghi\u1ec7m \u0111\u1ecbnh k\u1ef3.<\/p>\n<p>\u0110\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc v\u00e0 trong khi \u0111i\u1ec1u tr\u1ecb; kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 CrCl &lt;15 mL\/ph\u00fat n\u1ebfu kh\u00f4ng ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o.<\/p>\n<p>D\u1eef li\u1ec7u v\u1ec1 hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n \u1edf ng\u01b0\u1eddi \u0111\u1ed3ng nhi\u1ec5m HBV v\u1edbi HCV ho\u1eb7c HDV hi\u1ec7n c\u00f2n h\u1ea1n ch\u1ebf<\/p>\n<p>Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, c\u1ea7n s\u00e0ng l\u1ecdc HIV; n\u1ebfu \u0111\u1ed3ng nhi\u1ec5m HBV\/HIV ph\u1ea3i ph\u1ed1i h\u1ee3p v\u1edbi ph\u00e1c \u0111\u1ed3 kh\u00e1ng HIV th\u00edch h\u1ee3p.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>T\u1ea7n su\u1ea5t r\u1ea5t ph\u1ed5 bi\u1ebfn: Ng\u01b0\u1eddi b\u1ec7nh th\u01b0\u1eddng xuy\u00ean g\u1eb7p ph\u1ea3i tri\u1ec7u ch\u1ee9ng nh\u1ee9c \u0111\u1ea7u.<\/p>\n<p>T\u1ea7n su\u1ea5t ph\u1ed5 bi\u1ebfn: Th\u01b0\u1eddng ghi nh\u1eadn c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 m\u1ec7t m\u1ecfi, cho\u00e1ng v\u00e1ng, \u0111au nh\u1ee9c kh\u1edbp, ng\u1ee9a ng\u00e1y ho\u1eb7c ph\u00e1t ban ngo\u00e0i da. B\u00ean c\u1ea1nh \u0111\u00f3, c\u00e1c d\u1ea5u hi\u1ec7u r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng ru\u1ed9t bao g\u1ed3m \u0111\u1ea7y h\u01a1i, tr\u01b0\u1edbng b\u1ee5ng, \u0111au qu\u1eb7n b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n m\u1eeda, \u0111i ngo\u00e0i ph\u00e2n l\u1ecfng, c\u00f9ng v\u1edbi hi\u1ec7n t\u01b0\u1ee3ng t\u0103ng n\u1ed3ng \u0111\u1ed9 men gan ALT huy\u1ebft thanh c\u0169ng r\u1ea5t hay x\u1ea3y ra.<\/p>\n<p>T\u1ea7n su\u1ea5t \u00edt ph\u1ed5 bi\u1ebfn: Th\u1ec9nh tho\u1ea3ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng n\u1ed5i m\u1ec1 \u0111ay ho\u1eb7c ph\u00f9 m\u1ea1ch.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Vi\u1ec7c ph\u1ed1i h\u1ee3p \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c d\u01b0\u1ee3c ch\u1ea5t kh\u00e1c c\u00f9ng nh\u00f3m ho\u1eb7c d\u1eabn ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 nh\u01b0 tenofovir disoproxil, adefovir dipivoxil hay ch\u00ednh tenofovir alafenamid l\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p.<\/p>\n<p>N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u c\u00f3 th\u1ec3 b\u1ecb s\u1ee5t gi\u1ea3m nghi\u00eam tr\u1ecdng d\u1eabn \u0111\u1ebfn m\u1ea5t hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ebfu d\u00f9ng chung v\u1edbi c\u00e1c ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng P-gp.<\/p>\n<p>S\u1ef1 gia t\u0103ng h\u00e0m l\u01b0\u1ee3ng thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 nguy c\u01a1 x\u1ea3y ra khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh P-gp v\u00e0 BCRP.<\/p>\n<p>Qu\u00e1 tr\u00ecnh ph\u00e2n b\u1ed1 ho\u1ea1t ch\u1ea5t trong c\u01a1 th\u1ec3 ch\u1ecbu s\u1ef1 chi ph\u1ed1i v\u00e0 \u1ea3nh h\u01b0\u1edfng in vitro t\u1eeb ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c h\u1ec7 v\u1eadn chuy\u1ec3n OATP1B1 v\u00e0 OATP1B3.<\/p>\n<p>Kh\u00f4ng d\u00f9ng chung: Thu\u1ed1c kh\u00e1ng mycobacteria (rifampicin, rifapentin, rifabutin); Thu\u1ed1c ch\u1ed1ng co gi\u1eadt (carbamazepin, oxcarbazepin, phenobarbital, phenytoin); Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb HIV nh\u00f3m \u1ee9c ch\u1ebf protease (atazanavir, cobicistat, ritonavir, darunavir, lopinavir, tipranavir); Thu\u1ed1c ch\u1ed1ng n\u1ea5m (itraconazol, ketoconazol); Th\u1ef1c ph\u1ea9m b\u1ea3o suy\u1ec3n s\u1ee9c kh\u1ecfe ch\u1ee9a St. John&#8217;s wort.<\/p>\n<p>Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u: Thu\u1ed1c an th\u1ea7n\/g\u00e2y m\u00ea (midazolam); Thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng (norgestimat\/ethinylestradiol); Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (sertralin); Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb HIV nh\u00f3m \u1ee9c ch\u1ebf integrase (dolutegravir, raltegravir), nh\u00f3m NNRTI (efavirenz, nevirapin, rilpivirine) v\u00e0 nh\u00f3m \u0111\u1ed1i kh\u00e1ng CCR5 (maraviroc); Thu\u1ed1c kh\u00e1ng virus HCV (sofosbuvir, ledipasvir, velpatasvir, voxilaprevir).<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Hi\u1ec7n c\u00f3 r\u1ea5t \u00edt d\u1eef li\u1ec7u (d\u01b0\u1edbi 300 ca) v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng tenofovir alafenamide \u1edf ph\u1ee5 n\u1eef mang thai. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng ghi nh\u1eadn \u0111\u1ed9c t\u00ednh sinh s\u1ea3n, \u0111\u1ed3ng th\u1eddi d\u1eef li\u1ec7u di\u1ec7n r\u1ed9ng t\u1eeb h\u01a1n 1.000 thai ph\u1ee5 d\u00f9ng tenofovir disoproxil c\u0169ng cho th\u1ea5y kh\u00f4ng c\u00f3 nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt cho thai nhi hay tr\u1ebb s\u01a1 sinh. Do \u0111\u00f3, ch\u1ec9 n\u00ean c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng tenofovir alafenamide trong thai k\u1ef3 khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p>Ch\u01b0a c\u00f3 k\u1ebft lu\u1eadn ch\u00ednh th\u1ee9c v\u1ec1 vi\u1ec7c tenofovir alafenamide c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 hay kh\u00f4ng, d\u00f9 c\u00e1c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 ghi nh\u1eadn \u0111i\u1ec1u n\u00e0y. V\u00ec ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi tr\u1ebb nh\u1ecf v\u00e0 kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb ho\u00e0n to\u00e0n c\u00e1c r\u1ee7i ro \u0111\u1ed1i v\u1edbi tr\u1ebb b\u00fa m\u1eb9, c\u00e1c chuy\u00ean gia khuy\u1ebfn c\u00e1o kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng tenofovir alafenamide trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/p>\n<p>\u0110\u1ebfn nay, ch\u01b0a c\u00f3 b\u1eb1ng ch\u1ee9ng t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean ng\u01b0\u1eddi v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a tenofovir alafenamid \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n. D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y thu\u1ed1c kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng c\u00f3 h\u1ea1i \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng tenofovir alafenamid \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 \u00edt ho\u1eb7c kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. D\u00f9 v\u1eady, n\u1ebfu xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng ch\u00f3ng m\u1eb7t trong th\u1eddi gian d\u00f9ng thu\u1ed1c, ng\u01b0\u1eddi b\u1ec7nh n\u00ean h\u1ea1n ch\u1ebf th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ea7n s\u1ef1 t\u1eadp trung cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Vi\u1ec7c gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd bi\u1ec3u hi\u1ec7n ng\u1ed9 \u0111\u1ed9c l\u00e0 b\u1eaft bu\u1ed9c \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi b\u1ec7nh trong t\u00ecnh hu\u1ed1ng d\u00f9ng qu\u00e1 li\u1ec1u quy \u0111\u1ecbnh.<\/p>\n<p>Quy tr\u00ecnh x\u1eed l\u00fd ch\u1ee7 y\u1ebfu t\u1eadp trung v\u00e0o ch\u0103m s\u00f3c, ki\u1ec3m tra ch\u1ee9c n\u0103ng s\u1ed1ng v\u00e0 \u0111\u00e1nh gi\u00e1 s\u00e1t sao di\u1ec5n ti\u1ebfn l\u00e2m s\u00e0ng.<\/p>\n<p>Bi\u1ec7n ph\u00e1p th\u1ea9m t\u00e1ch m\u00e1u cho hi\u1ec7u qu\u1ea3 l\u1ecdc t\u1ed1t v\u1edbi kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf tenofovir \u0111\u1ea1t t\u1ef7 l\u1ec7 kho\u1ea3ng 54%.<\/p>\n<p>Kh\u1ea3 n\u0103ng \u0111\u00e0o th\u1ea3i ho\u00e0n to\u00e0n ho\u1ea1t ch\u1ea5t n\u00e0y th\u00f4ng qua k\u1ef9 thu\u1eadt th\u1ea9m t\u00e1ch ph\u00fac m\u1ea1c hi\u1ec7n v\u1eabn ch\u01b0a c\u00f3 k\u1ebft lu\u1eadn r\u00f5 r\u00e0ng.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef TAF-5A \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 TAF-5A trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng TAF-5A khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c TAF-5A gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>TAF-5A hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c TAF-5A c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p TAF-5A t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi TAF-5A nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/thuoc-hepa-taf-25mg\/\">Hepa-Taf 25mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Tenofovir alafenamide h\u00e0m l\u01b0\u1ee3ng 25mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH BRV Healthcare, \u0111i\u1ec1u tr\u1ecb vi\u00eam gan B m\u1ea1n t\u00ednh<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/tenofovir-alafenamide-25mg\/\">Tenofovir Alafenamide 25mg <\/a>c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Tenofovir alafenamide h\u00e0m l\u01b0\u1ee3ng 25mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m qu\u1ed1c t\u1ebf CT Pharma, \u0111i\u1ec1u tr\u1ecb vi\u00eam gan B m\u1ea1n t\u00ednh<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c TAF-5A \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/07\/huong-dan-su-dung-TAF-5A-vnras.pdf\">t\u1ea1i \u0111\u00e2y.<\/a> Truy c\u1eadp ng\u00e0y 10 th\u00e1ng 6 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/dichvucong.dav.gov.vn\/congbothuoc\" rel=\"noopener\">https:\/\/dichvucong.dav.gov.vn\/congbothuoc<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>TAF-5A \u0111i\u1ec1u tr\u1ecb vi\u00eam gan B m\u1ea1n t\u00ednh \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i c\u00f3 c\u00e2n n\u1eb7ng t\u1eeb 35 kg, gi\u00fap \u1ee9c ch\u1ebf s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a virus HBV v\u00e0 h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t b\u1ec7nh l\u00e2u d\u00e0i.<\/p>\n","protected":false},"author":1,"featured_media":160430,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-160424","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/160424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=160424"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/160430"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=160424"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=160424"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=160424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}