{"id":158278,"date":"2026-06-01T09:32:39","date_gmt":"2026-06-01T02:32:39","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=158278"},"modified":"2026-06-01T10:41:41","modified_gmt":"2026-06-01T03:41:41","slug":"alavir-e","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/alavir-e\/","title":{"rendered":"Alavir-E"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Alavir-E \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Sinh D\u01b0\u1ee3c ph\u1ea9m Hera c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 <\/b><strong>893110240723<\/strong><\/p>\n<h2>Alavir-E l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <b>vi\u00ean u\u1ed1ng Alavir-E <\/b>c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Tenofovir alafenamide (d\u01b0\u1edbi d\u1ea1ng Tenofovir alafenamide fumarate): 25mg.<\/li>\n<li>Emtricitabine: 200mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c g\u1ed3m: Cellulose vi tinh th\u1ec3 101, Natri croscarmellose, Copovidon, Magnesi stearat, Opadry II Blue v\u00e0 Opadry II White v\u1eeba \u0111\u1ee7 m\u1ed9t vi\u00ean.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110240723<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Alavir-E<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Emtricitabine: Thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf enzym phi\u00ean m\u00e3 ng\u01b0\u1ee3c nucleosid (NRTI). Khi v\u00e0o c\u01a1 th\u1ec3, ho\u1ea1t ch\u1ea5t bi\u1ebfn \u0111\u1ed5i th\u00e0nh d\u1ea1ng triphosphate inside t\u1ebf b\u00e0o, c\u1ea1nh tranh v\u00e0 g\u1eafn k\u1ebft v\u00e0o chu\u1ed7i DNA c\u1ee7a virus, l\u00e0m \u0111\u1ee9t g\u00e3y v\u00e0 d\u1eebng qu\u00e1 tr\u00ecnh sao ch\u00e9p m\u00e3 di truy\u1ec1n c\u1ee7a HIV-1, HIV-2 v\u00e0 virus vi\u00eam gan B (HBV).<\/p>\n<p>Tenofovir alafenamide: Thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf enzym phi\u00ean m\u00e3 ng\u01b0\u1ee3c nucleotid (NtRTI). L\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t c\u00f3 t\u00ednh \u1ed5n \u0111\u1ecbnh cao trong m\u00e1u, ho\u1ea1t ch\u1ea5t n\u00e0y x\u00e2m nh\u1eadp v\u00e0 t\u1eadp trung n\u1ed3ng \u0111\u1ed9 v\u01b0\u1ee3t tr\u1ed9i t\u1ea1i c\u00e1c t\u1ebf b\u00e0o \u0111\u00edch c\u1ee7a HIV (\u0111\u1ea1i th\u1ef1c b\u00e0o, t\u1ebf b\u00e0o lympho) so v\u1edbi d\u1ea1ng mu\u1ed1i disoproxil c\u0169. T\u1ea1i \u0111\u00e2y, n\u00f3 chuy\u1ec3n h\u00f3a th\u00e0nh tenofovir diphosphate, ng\u0103n ch\u1eb7n s\u1ef1 k\u00e9o d\u00e0i chu\u1ed7i DNA c\u1ee7a virus, \u1ee9c ch\u1ebf m\u1ea1nh m\u1ebd HIV-1, HIV-2 v\u00e0 HBV.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Emtricitabine: T\u1ed1c \u0111\u1ed9 h\u1ea5p thu nhanh, sau 1 &#8211; 2 gi\u1edd th\u00ec \u0111\u1ea1t \u0111\u1ec9nh trong m\u00e1u c\u00f2n Tenofovir alafenamide sau kho\u1ea3ng 1 gi\u1edd khi u\u1ed1ng l\u00fac no. N\u1ebfu d\u00f9ng chung v\u1edbi th\u1ef1c ph\u1ea9m gi\u00e0u ch\u1ea5t b\u00e9o, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh (Cmax) c\u1ee7a Tenofovir gi\u1ea3m nh\u1eb9 nh\u01b0ng t\u1ed5ng l\u01b0\u1ee3ng h\u1ea5p thu (AUC) t\u0103ng \u0111\u00e1ng k\u1ec3. c\u00f2n v\u1edbi Emtricitabine khi d\u00f9ng v\u1edbi th\u1ee9c \u0103n kh\u00f4ng g\u00e2y bi\u1ebfn \u0111\u1ed9ng \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 h\u1ea5p thu<\/p>\n<p>Ph\u00e2n b\u1ed1: T\u1ef7 l\u1ec7 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u r\u1ea5t th\u1ea5p (Emtricitabine &lt; 4%, Tenofovir t\u1ef1 do &lt; 0,7%). Ri\u00eang ti\u1ec1n ch\u1ea5t Tenofovir alafenamide g\u1eafn k\u1ebft kho\u1ea3ng 80% v\u1edbi protein m\u00e1u. Emtricitabine c\u00f3 kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp t\u1ed1t v\u00e0o tinh d\u1ecbch.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Emtricitabine \u00edt b\u1ecb chuy\u1ec3n h\u00f3a qua gan (ch\u1ec9 kho\u1ea3ng 13% chuy\u1ec3n th\u00e0nh d\u1ea1ng sulfoxide v\u00e0 glucuronide). Ng\u01b0\u1ee3c l\u1ea1i, Tenofovir alafenamide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh m\u1ebd (&gt;80% li\u1ec1u d\u00f9ng) ch\u1ee7 y\u1ebfu nh\u1edd c\u00e1c enzym n\u1ed9i b\u00e0o (cathepsin A v\u00e0 carboxylesterase-1) th\u00e0nh d\u1ea1ng ho\u1ea1t t\u00ednh, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o h\u1ec7 enzym CYP \u1edf gan.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Emtricitabine ch\u1ee7 y\u1ebfu \u0111\u00e0o th\u1ea3i nguy\u00ean v\u1eb9n qua \u0111\u01b0\u1eddng th\u1eadn (86% qua n\u01b0\u1edbc ti\u1ec3u) v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 10 gi\u1edd. Tenofovir alafenamide th\u1ea3i tr\u1eeb r\u1ea5t \u00edt qua n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n (&lt;1%), sau khi chuy\u1ec3n th\u00e0nh tenofovir s\u1ebd \u0111\u01b0\u1ee3c th\u1eadn b\u00e0i ti\u1ebft ra ngo\u00e0i v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i h\u01a1n 32 gi\u1edd.<\/p>\n<h2>Thu\u1ed1c Alavir-E \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng ph\u1ed1i h\u1ee3p c\u00f9ng c\u00e1c d\u00f2ng thu\u1ed1c kh\u00e1ng virus kh\u00e1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n nhi\u1ec5m HIV-1 \u0111\u1ed1i v\u1edbi c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng th\u1ee9 nh\u1ea5t l\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 t\u1ed1i thi\u1ec3u t\u1eeb 35kg v\u00e0 th\u1ee9 hai l\u00e0 ng\u01b0\u1eddi l\u1edbn<\/p>\n<figure id=\"attachment_158280\" aria-describedby=\"caption-attachment-158280\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-158280\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E.jpg\" alt=\"Alavir-E\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/Alavir-E-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-158280\" class=\"wp-caption-text\">Thu\u1ed1c Alavir-E tr\u1ecb nhi\u1ec5m HIV-1 \u1edf ng\u01b0\u1eddi l\u1edbn, thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>\u00c1p d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb tr\u00ean 12 tu\u1ed5i (n\u1eb7ng \u2265 35 kg) v\u1edbi t\u1ea7n su\u1ea5t 1 vi\u00ean\/l\u1ea7n\/ng\u00e0y, c\u1ee5 th\u1ec3 theo ph\u00e1c \u0111\u1ed3 \u0111i k\u00e8m:<\/p>\n<ul>\n<li>Khi ph\u1ed1i h\u1ee3p v\u1edbi: Atazanavir (k\u00e8m ritonavir\/cobicistat), Darunavir (k\u00e8m ritonavir\/cobicistat), ho\u1eb7c Lopinavir (k\u00e8m ritonavir).<\/li>\n<li>Khi ph\u1ed1i h\u1ee3p v\u1edbi: Dolutegravir, Rilpivirine, Efavirenz, Maraviroc, Nevirapine, ho\u1eb7c Raltegravir.<\/li>\n<\/ul>\n<p>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi gi\u00e0 &amp; Suy gan: Kh\u00f4ng c\u1ea7n thay \u0111\u1ed5i li\u1ec1u l\u01b0\u1ee3ng.<\/li>\n<li>Suy th\u1eadn: Kh\u00f4ng ch\u1ec9nh li\u1ec1u n\u1ebfu \u0111\u1ed9 thanh th\u1ea3i Creatinin (CrCI) \u2265 30 ml\/ph\u00fat. \u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i (CrCl &lt; 15 ml\/ph\u00fat) \u0111ang ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o \u0111\u1ecbnh k\u1ef3: Ch\u1ec9 d\u00f9ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 ph\u1ea3i u\u1ed1ng thu\u1ed1c sau khi qu\u00e1 tr\u00ecnh l\u1ecdc m\u00e1u k\u1ebft th\u00fac. Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho ng\u01b0\u1eddi c\u00f3 CrCl t\u1eeb 15 \u0111\u1ebfn d\u01b0\u1edbi 30 ml\/ph\u00fat, ho\u1eb7c d\u01b0\u1edbi 15 ml\/ph\u00fat m\u00e0 kh\u00f4ng ch\u1ea1y th\u1eadn.<\/li>\n<li>Tr\u1ebb em: Kh\u00f4ng d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 12 tu\u1ed5i ho\u1eb7c nh\u1eb9 h\u01a1n 35 kg.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Kh\u00f4ng nhai, b\u1ebb, nghi\u1ec1n, ch\u1ec9 u\u1ed1ng nguy\u00ean vi\u00ean <b>n\u00e9n Alavir-E<\/b> \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 th\u1ec3 u\u1ed1ng l\u00fac \u0111\u00f3i ho\u1eb7c l\u00fac no.<\/p>\n<p>X\u1eed tr\u00ed khi qu\u00ean li\u1ec1u ho\u1eb7c n\u00f4n thu\u1ed1c:<\/p>\n<ul>\n<li>Qu\u00ean d\u01b0\u1edbi 18 ti\u1ebfng: U\u1ed1ng b\u00f9 ngay khi nh\u1edb ra v\u00e0 duy tr\u00ec l\u1ecbch u\u1ed1ng ti\u1ebfp theo nh\u01b0 c\u0169.<\/li>\n<li>Qu\u00ean tr\u00ean 18 ti\u1ebfng: B\u1ecf qua li\u1ec1u c\u0169, \u0111\u1ee3i li\u1ec1u k\u1ebf ti\u1ebfp theo \u0111\u00fang l\u1ecbch, kh\u00f4ng u\u1ed1ng g\u1ea5p \u0111\u00f4i.<\/li>\n<li>B\u1ecb n\u00f4n trong v\u00f2ng 1 gi\u1edd sau khi u\u1ed1ng: C\u1ea7n u\u1ed1ng b\u00f9 ngay 1 vi\u00ean kh\u00e1c.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Alavir-E trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Tenofovir alafenamide, Emtricitabine ho\u1eb7c v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Alavir-E<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Thu\u1ed1c kh\u00f4ng tri\u1ec7t ti\u00eau ho\u00e0n to\u00e0n kh\u1ea3 n\u0103ng truy\u1ec1n b\u1ec7nh qua \u0111\u01b0\u1eddng t\u00ecnh d\u1ee5c, duy tr\u00ec c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba theo quy \u0111\u1ecbnh.<\/p>\n<p>D\u00f9ng thu\u1ed1c d\u1ec5 b\u1ecb nhi\u1ec5m \u0111\u1ed9c gan n\u1eb7ng d\u1eabn \u0111\u1ebfn t\u1eed vong, d\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 khi\u1ebfn vi\u00eam gan B b\u00f9ng ph\u00e1t d\u1eef d\u1ed9i (c\u1ea7n theo d\u00f5i s\u00e1t v\u00e0i th\u00e1ng sau \u0111\u00f3).<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed suy gan khi d\u00f9ng Alavir-E c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ec9 s\u1ed1 men gan, ng\u1eaft ho\u1eb7c d\u1eebng \u0111i\u1ec1u tr\u1ecb n\u1ebfu b\u1ec7nh gan chuy\u1ec3n bi\u1ebfn x\u1ea5u.<\/p>\n<p>C\u1ea3nh gi\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng c\u00e2n, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 m\u1ee1 m\u00e1u, c\u1ea7n \u0111\u1ecbnh k\u1ef3 x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u1ec3 x\u1eed l\u00fd.<\/p>\n<p>Tr\u1ebb s\u01a1 sinh ph\u01a1i nhi\u1ec5m thu\u1ed1c t\u1eeb trong b\u1ee5ng m\u1eb9 c\u00f3 th\u1ec3 b\u1ecb bi\u1ebfn \u0111\u1ed5i huy\u1ebft h\u1ecdc, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a tho\u00e1ng qua ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh mu\u1ed9n.<\/p>\n<p>H\u1ed9i ch\u1ee9ng ph\u1ee5c h\u1ed3i mi\u1ec5n d\u1ecbch khi d\u00f9ng thu\u1ed1c d\u1ec5 k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng vi\u00eam c\u1ea5p t\u00ednh v\u1edbi c\u00e1c m\u1ea7m b\u1ec7nh \u1ea9n n\u1ea5p ho\u1eb7c kh\u1edfi ph\u00e1t b\u1ec7nh t\u1ef1 mi\u1ec5n sau v\u00e0i th\u00e1ng.<\/p>\n<p>Tr\u00e1nh d\u00f9ng cho ng\u01b0\u1eddi nhi\u1ec5m HIV-1 mang \u0111\u1ed9t bi\u1ebfn K65R \u0111\u00e3 t\u1eebng can thi\u1ec7p y t\u1ebf tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Kh\u00f4ng t\u1ef1 \u00fd ph\u1ed1i h\u1ee3p th\u00eam m\u1ed9t ho\u1ea1t ch\u1ea5t nucleosid th\u1ee9 ba do r\u1ee7i ro th\u1ea5t b\u1ea1i ph\u00e1c \u0111\u1ed3 v\u00e0 sinh \u0111\u1ec1 kh\u00e1ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n v\u1eabn c\u00f3 nguy c\u01a1 m\u1eafc c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng th\u1ee9 ph\u00e1t, y\u00eau c\u1ea7u b\u00e1c s\u0129 chuy\u00ean khoa gi\u00e1m s\u00e1t li\u00ean t\u1ee5c.<\/p>\n<p>Nguy c\u01a1 ho\u1ea1i t\u1eed x\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi b\u1ec7nh n\u1eb7ng ho\u1eb7c d\u00f9ng thu\u1ed1c k\u00e9o d\u00e0i, b\u00e1o ngay cho b\u00e1c s\u0129 n\u1ebfu b\u1ecb \u0111au, c\u1ee9ng kh\u1edbp.<\/p>\n<p>Ti\u1ec1m \u1ea9n r\u1ee7i ro t\u00edch t\u1ee5 \u0111\u1ed9c t\u00ednh g\u00e2y h\u1ea1i cho th\u1eadn khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c d\u00e0i ng\u00e0y.<\/p>\n<p>H\u1ea1n ch\u1ebf d\u00f9ng cho b\u1ec7nh nh\u00e2n ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o (CrCl &lt; 15 ml\/ph\u00fat), n\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i d\u00f9ng, l\u01b0u \u00fd thu\u1ed1c l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 emtricitabine trong m\u00e1u.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t ph\u1ed5 bi\u1ebfn: C\u1ea3m gi\u00e1c bu\u1ed3n n\u00f4n.<\/p>\n<p>Ph\u1ed5 bi\u1ebfn:<\/p>\n<ul>\n<li><i>H\u1ec7 ti\u00eau h\u00f3a:<\/i> B\u1ecb ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda, \u0111au t\u1ee9c v\u00f9ng b\u1ee5ng, \u0111\u1ea7y b\u1ee5ng kh\u00f3 ti\u00eau.<\/li>\n<li><i>H\u1ec7 th\u1ea7n kinh v\u00e0 t\u00e2m th\u1ea7n:<\/i> \u0110au \u0111\u1ea7u, xu\u1ea5t hi\u1ec7n c\u00e1c gi\u1ea5c m\u01a1 d\u1ecb th\u01b0\u1eddng, c\u00f3 c\u1ea3m gi\u00e1c ch\u00f3ng m\u1eb7t.<\/li>\n<li><i>Da li\u1ec5u:<\/i> Da b\u1ecb n\u1ed5i m\u1ea9n, ph\u00e1t ban.<\/li>\n<li><i>To\u00e0n th\u00e2n:<\/i> C\u01a1 th\u1ec3 u\u1ec3 o\u1ea3i, m\u1ec7t m\u1ecfi.<\/li>\n<\/ul>\n<p>\u00cdt g\u1eb7p:<\/p>\n<ul>\n<li><i>H\u1ec7 m\u00e1u:<\/i> T\u00ecnh tr\u1ea1ng thi\u1ebfu m\u00e1u.<\/li>\n<li><i>H\u1ec7 ti\u00eau h\u00f3a:<\/i> Ch\u1ee9ng kh\u00f3 ti\u00eau.<\/li>\n<li><i>Da li\u1ec5u v\u00e0 m\u00f4 d\u01b0\u1edbi da:<\/i> Ng\u1ee9a ng\u00e1y, n\u1ed5i m\u1ec1 \u0111ay, s\u01b0ng ph\u00f9 m\u1ea1ch.<\/li>\n<li><i>H\u1ec7 c\u01a1 x\u01b0\u01a1ng:<\/i> \u0110au nh\u1ee9c c\u00e1c kh\u1edbp.<\/li>\n<\/ul>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 ch\u1ecdn l\u1ecdc kh\u00e1c: C\u00f3 th\u1ec3 x\u1ea3y ra h\u1ed9i ch\u1ee9ng ph\u1ee5c h\u1ed3i mi\u1ec5n d\u1ecbch.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p><b>T\u01b0\u01a1ng t\u00e1c chung:<\/b> C\u1ea5m d\u00f9ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c n\u00e0y v\u1edbi b\u1ea5t k\u1ef3 ch\u1ebf ph\u1ea9m n\u00e0o kh\u00e1c c\u00f3 ch\u1ee9a c\u00e1c ho\u1ea1t ch\u1ea5t: tenofovir alafenamide, tenofovir disoproxil, emtricitabine, lamivudine ho\u1eb7c adefovir dipivoxil.<\/p>\n<p><b>Li\u00ean quan \u0111\u1ebfn Emtricitabine:<\/b><\/p>\n<ul>\n<li>Nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c th\u00f4ng qua h\u1ec7 enzym CYP \u1edf gan l\u00e0 r\u1ea5t th\u1ea5p.<\/li>\n<li>Khi d\u00f9ng chung v\u1edbi c\u00e1c thu\u1ed1c \u0111\u00e0o th\u1ea3i qua \u0111\u01b0\u1eddng b\u00e0i ti\u1ebft ch\u1ee7 \u0111\u1ed9ng \u1edf \u1ed1ng th\u1eadn ho\u1eb7c c\u00e1c thu\u1ed1c l\u00e0m suy gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1eadn, n\u1ed3ng \u0111\u1ed9 c\u1ee7a emtricitabine v\u00e0\/ho\u1eb7c c\u1ee7a thu\u1ed1c ph\u1ed1i h\u1ee3p c\u00f9ng trong m\u00e1u c\u00f3 th\u1ec3 b\u1ecb \u0111\u1ea9y l\u00ean cao.<\/li>\n<\/ul>\n<p><b>Li\u00ean quan \u0111\u1ebfn Tenofovir alafenamide:<\/b><\/p>\n<ul>\n<li>C\u00e1c ch\u1ea5t l\u00e0m gi\u1ea3m h\u1ea5p thu: C\u00e1c thu\u1ed1c k\u00edch th\u00edch ho\u1eb7c l\u00e0m c\u1ea3m \u1ee9ng m\u1ea1nh P-gp (v\u00ed d\u1ee5: rifampicin, rifabutin, carbamazepine, phenobarbital) s\u1ebd l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng tenofovir alafenamide \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o m\u00e1u, khi\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c s\u1ee5t gi\u1ea3m, d\u1eabn t\u1edbi m\u1ea5t t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u0103ng nguy c\u01a1 kh\u00e1ng thu\u1ed1c.<\/li>\n<li>C\u00e1c ch\u1ea5t l\u00e0m t\u0103ng h\u1ea5p thu: C\u00e1c thu\u1ed1c c\u00f3 t\u00ednh ch\u1ea5t \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a P-gp v\u00e0 BCRP (nh\u01b0 cobicistat, ritonavir, ciclosporin) s\u1ebd l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng h\u1ea5p thu v\u00e0 \u0111\u1ea9y n\u1ed3ng \u0111\u1ed9 tenofovir alafenamide trong m\u00e1u l\u00ean cao.<\/li>\n<li>C\u00e1c men v\u1eadn chuy\u1ec3n: Ho\u1ea1t ch\u1ea5t n\u00e0y l\u00e0 c\u01a1 ch\u1ea5t c\u1ee7a OATP1B1 v\u00e0 OATP1B3, do \u0111\u00f3 s\u1ef1 ph\u00e2n ph\u1ed1i thu\u1ed1c trong c\u01a1 th\u1ec3 ch\u1ecbu s\u1ef1 t\u00e1c \u0111\u1ed9ng t\u1eeb ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c h\u1ec7 v\u1eadn chuy\u1ec3n n\u00e0y.<\/li>\n<li>L\u01b0u \u00fd kh\u00e1c: D\u1ef1a tr\u00ean d\u1eef li\u1ec7u th\u1eed nghi\u1ec7m in vitro, vi\u1ec7c ph\u1ed1i h\u1ee3p ho\u1ea1t ch\u1ea5t n\u00e0y v\u1edbi c\u00e1c d\u00f2ng thu\u1ed1c \u1ee9c ch\u1ebf xanthine oxidase (nh\u01b0 febuxostat) \u0111\u01b0\u1ee3c d\u1ef1 \u0111o\u00e1n l\u00e0 kh\u00f4ng l\u00e0m gia t\u0103ng n\u1ed3ng \u0111\u1ed9 tenofovir trong c\u01a1 th\u1ec3 tr\u00ean th\u1ef1c t\u1ebf l\u00e2m s\u00e0ng.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u00e0 c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u00e1nh gi\u00e1 vi\u1ec7c s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p tenofovir alafenamide v\u00e0 emtricitabine tr\u00ean ph\u1ee5 n\u1eef mang thai. Ch\u1ec9 n\u00ean c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng thu\u1ed1c khi \u0111\u00e3 th\u1ea3o lu\u1eadn v\u00e0 \u0111\u00e1nh gi\u00e1 nguy c\u01a1-an to\u00e0n c\u00f9ng b\u00e1c s\u0129<\/p>\n<p>Ch\u01b0a c\u00f3 b\u00e1o c\u00e1o ch\u00ednh x\u00e1c v\u1ec1 vi\u1ec7c tenofovir alafenamide c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng, tuy nhi\u00ean c\u00e1c kh\u1ea3o s\u00e1t \u1edf \u0111\u1ed9ng v\u1eadt x\u00e1c nh\u1eadn tenofovir c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa. Ri\u00eang ho\u1ea1t ch\u1ea5t emtricitabine \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. Do thi\u1ebfu d\u1eef li\u1ec7u an to\u00e0n c\u1ee7a c\u1ea3 hai ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u1ed1i v\u1edbi tr\u1ebb nh\u1ecf v\u00e0 nguy c\u01a1 truy\u1ec1n virus HIV sang cho con, kh\u00f4ng khuy\u1ebfn c\u00e1o m\u1eb9 d\u00f9ng thu\u1ed1c c\u0169ng nh\u01b0 cho con b\u00fa<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o tr\u01b0\u1edbc v\u1ec1 kh\u1ea3 n\u0103ng xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng ch\u00f3ng m\u1eb7t trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c n\u00e0y. Do \u0111\u00f3, c\u1ea7n th\u1eadn tr\u1ecdng n\u1ebfu \u0111ang l\u00e0m nh\u1eefng c\u00f4ng vi\u1ec7c d\u00f9ng m\u00e1y m\u00f3c ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n \u0111i l\u1ea1i<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Bi\u1ec3u hi\u1ec7n v\u00e0 theo d\u00f5i: Khi d\u00f9ng qu\u00e1 li\u1ec1u quy \u0111\u1ecbnh, c\u1ea7n ti\u1ebfn h\u00e0nh theo d\u00f5i ch\u1eb7t ch\u1ebd ng\u01b0\u1eddi b\u1ec7nh \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c bi\u1ec3u hi\u1ec7n nhi\u1ec5m \u0111\u1ed9c. Qu\u00e1 tr\u00ecnh x\u1eed l\u00fd ch\u1ee7 y\u1ebfu t\u1eadp trung v\u00e0o c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 t\u1ed5ng qu\u00e1t, bao g\u1ed3m vi\u1ec7c ki\u1ec3m tra s\u00e1t sao c\u00e1c d\u1ea5u hi\u1ec7u sinh t\u1ed3n v\u00e0 gi\u00e1m s\u00e1t di\u1ec5n ti\u1ebfn l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p><i>Emtricitabine:<\/i> C\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i m\u1ed9t ph\u1ea7n th\u00f4ng qua ph\u01b0\u01a1ng ph\u00e1p ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o. C\u1ee5 th\u1ec3, m\u1ed9t li\u1ec7u tr\u00ecnh th\u1ea9m ph\u00e2n m\u00e1u k\u00e9o d\u00e0i 3 gi\u1edd (b\u1eaft \u0111\u1ea7u trong v\u00f2ng 1.5 gi\u1edd k\u1ec3 t\u1eeb l\u00fac d\u00f9ng thu\u1ed1c) c\u00f3 kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf kho\u1ea3ng 30% l\u01b0\u1ee3ng emtricitabine trong c\u01a1 th\u1ec3.<\/p>\n<p><i>Tenofovir:<\/i> Ph\u01b0\u01a1ng ph\u00e1p ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 lo\u1ea1i b\u1ecf ho\u1ea1t ch\u1ea5t n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i cao, v\u1edbi h\u1ec7 s\u1ed1 thanh l\u1ecdc \u0111\u1ea1t kho\u1ea3ng 54%.<\/p>\n<p><i>L\u01b0u \u00fd:<\/i> Hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u ch\u1ee9ng minh li\u1ec7u hai ho\u1ea1t ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u1ecdc b\u1ecf th\u00f4ng qua ph\u01b0\u01a1ng ph\u00e1p th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c (l\u1ecdc m\u00e0ng b\u1ee5ng) hay kh\u00f4ng.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Alavir-E \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Alavir-E trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Alavir-E khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Alavir-E gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Alavir-E hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Alavir-E c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Alavir-E t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Alavir-E nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/spegra-50mg-200mg-25mg-emcure\/\">Spegra 50mg\/200mg\/25mg Emcure<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Tenofovir 25mg, Emtricitabine 200mg, Dolutegravir 50mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Emcure Pharmaceuticals, \u0111i\u1ec1u tr\u1ecb HIV &#8211; AIDS<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/tocitaf-50mg-200mg-25mg\/\">Tocitaf 50mg\/200mg\/25mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Tenofovir 25mg, Emtricitabine 200mg, Dolutegravir 50mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng Ty D\u01b0\u1ee3c Ph\u1ea9m Mylan Laboratories Limited, \u0111i\u1ec1u tr\u1ecb HIV &#8211; AIDS<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Alavir-E \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2026\/06\/to-huong-dan-su-dung-Alavir-E-vnras.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 1 th\u00e1ng 6 n\u0103m 2026 t\u1eeb: <a href=\"https:\/\/dichvucong.dav.gov.vn\/congbothuoc\" rel=\"noopener\">https:\/\/dichvucong.dav.gov.vn\/congbothuoc<\/a><\/li>\n<li>Mayer KH, Molina JM, Thompson MA, Anderson PL, Mounzer KC, De Wet JJ, DeJesus E, Jessen H, Grant RM, Ruane PJ, Wong P, Ebrahimi R, Zhong L, Mathias A, Callebaut C, Collins SE, Das M, McCallister S, Brainard DM, Brinson C, Clarke A, Coll P, Post FA, Hare CB (2020). Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial. Lancet. Truy c\u1eadp ng\u00e0y 1 th\u00e1ng 6 n\u0103m 2026 t\u1eeb: <a style=\"font-size: 14.4px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32711800\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32711800\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Alavir-E ch\u1ee9a Tenofovir alafenamide v\u00e0 Emtricitabine, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng virus kh\u00e1c trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m HIV-1 cho ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean<\/p>\n","protected":false},"author":1,"featured_media":158283,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-158278","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/158278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=158278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/158283"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=158278"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=158278"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=158278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}