{"id":157825,"date":"2026-05-20T09:56:11","date_gmt":"2026-05-20T02:56:11","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=157825"},"modified":"2026-05-20T16:46:30","modified_gmt":"2026-05-20T09:46:30","slug":"quelept-25mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/quelept-25mg\/","title":{"rendered":"Quelept 25mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Quelept 25mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Ilko Ilac San. ve Tic. A.S c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-22739-21<\/b><\/p>\n

Quelept 25mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Trong m\u1ed7i vi\u00ean u\u1ed1ng Quelept 25mg<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n

    \n
  • Quetiapin (d\u01b0\u1edbi d\u1ea1ng Quetiapin fumarat): 25mg<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n

    D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n

    Tr\u00ecnh b\u00e0y<\/h3>\n

    S\u0110K: VN-22739-21<\/p>\n

    Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n

    Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n

    H\u1ea1n s\u1eed d\u1ee5ng: 24 th\u00e1ng<\/p>\n

    T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Quelept 25mg<\/h2>\n

    C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n

    Quetiapin fumarat l\u00e0 ho\u1ea1t ch\u1ea5t thu\u1ed9c nh\u00f3m thu\u1ed1c an th\u1ea7n kinh kh\u00f4ng \u0111i\u1ec3n h\u00ecnh c\u00f3 c\u1ea5u tr\u00fac dibenzothiazepin. Thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean nhi\u1ec1u th\u1ee5 th\u1ec3 th\u1ea7n kinh kh\u00e1c nhau g\u1ed3m th\u1ee5 th\u1ec3 serotonin 5-HT2, dopamin D1\/D2, histamin H\u2081 v\u00e0 th\u1ee5 th\u1ec3 alpha-adrenergic. S\u1ef1 ph\u1ed1i h\u1ee3p t\u00e1c \u0111\u1ed9ng tr\u00ean c\u00e1c h\u1ec7 th\u1ee5 th\u1ec3 n\u00e0y gi\u00fap h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t c\u00e1c bi\u1ec3u hi\u1ec7n r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n c\u0169ng nh\u01b0 g\u00f3p ph\u1ea7n \u0111i\u1ec1u h\u00f2a c\u1ea3m x\u00fac \u1edf ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n

    \u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

    H\u1ea5p thu: Sau khi u\u1ed1ng, ho\u1ea1t ch\u1ea5t v\u00e0o c\u01a1 th\u1ec3 t\u1ed1t v\u00e0 \u0111\u1ea1t l\u01b0\u1ee3ng \u0111\u1ec9nh trong m\u00e1u sau ch\u1eebng 1,5 ti\u1ebfng, hi\u1ec7u qu\u1ea3 n\u00e0y kh\u00f4ng b\u1ecb t\u00e1c \u0111\u1ed9ng b\u1edfi th\u1ee9c \u0103n.<\/p>\n

    Ph\u00e2n b\u1ed1: Thu\u1ed1c \u0111i v\u00e0o s\u1eefa m\u1eb9 v\u00e0 ph\u00e2n t\u00e1n kh\u1eafp c\u00e1c m\u00f4 c\u01a1 th\u1ec3, v\u1edbi t\u1ef7 l\u1ec7 li\u00ean k\u1ebft c\u00f9ng protein huy\u1ebft t\u01b0\u01a1ng ~ 83%.<\/p>\n

    Chuy\u1ec3n h\u00f3a: Ho\u1ea1t ch\u1ea5t bi\u1ebfn \u0111\u1ed5i sinh h\u1ecdc \u1edf gan, ch\u1ee7 y\u1ebfu qua ph\u1ea3n \u1ee9ng sulfoxid h\u00f3a (nh\u1edd men CYP3A4 c\u1ee7a h\u1ec7 cytochrom P450) v\u00e0 oxy h\u00f3a.<\/p>\n

    Th\u1ea3i tr\u1eeb: Chu k\u1ef3 b\u00e1n h\u1ee7y k\u00e9o d\u00e0i 6 – 7 gi\u1edd. Thu\u1ed1c \u0111\u00e0o th\u1ea3i ra ngo\u00e0i \u0111a s\u1ed1 d\u01b0\u1edbi d\u1ea1ng m\u1ea5t ho\u1ea1t t\u00ednh, c\u1ee5 th\u1ec3 ~ 73% qua \u0111\u01b0\u1eddng ti\u1ec3u v\u00e0 g\u1ea7n 20% \u0111i theo ph\u00e2n.<\/p>\n

    Nh\u00f3m \u0111\u1eb7c bi\u1ec7t: T\u1ed1c \u0111\u1ed9 thanh th\u1ea3i huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m kho\u1ea3ng 25% \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinin < 30 ml\/ph\u00fat\/1,73m2) v\u00e0 s\u1ee5t gi\u1ea3m t\u1eeb 30% \u0111\u1ebfn 50% \u1edf nh\u00f3m ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n

    Thu\u1ed1c Quelept 25mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

    B\u1ec7nh l\u00fd t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t.<\/p>\n

    C\u00e1c th\u1ec3 tr\u1ea1ng thu\u1ed9c h\u1ed9i ch\u1ee9ng r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c bao g\u1ed3m:<\/p>\n

      \n
    • C\u00e1c \u0111\u1ee3t h\u01b0ng c\u1ea3m c\u1ea5p t\u00ednh li\u00ean quan \u0111\u1ebfn ch\u1ee9ng r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/li>\n
    • C\u00e1c giai \u0111o\u1ea1n tr\u1ea7m c\u1ea3m m\u1ee9c \u0111\u1ed9 n\u1eb7ng n\u1eb1m trong b\u1ec7nh c\u1ea3nh r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/li>\n
    • Duy tr\u00ec \u0111\u1ec3 ph\u00f2ng ng\u1eeba nguy c\u01a1 t\u00e1i ph\u00e1t \u0111\u1ecbnh k\u1ef3 cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed m\u1eafc c\u01a1n h\u1ed7n h\u1ee3p, h\u01b0ng c\u1ea3m ho\u1eb7c tr\u1ea7m c\u1ea3m \u0111\u00e3 c\u00f3 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb t\u1ed1t v\u1edbi ho\u1ea1t ch\u1ea5t quetiapin tr\u01b0\u1edbc \u0111\u00f3.<\/li>\n<\/ul>\n
      \"Quelept
      Quelept 25mg \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u00e0 r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c<\/figcaption><\/figure>\n

      Thu\u1ed1c Quelept 25mg c\u00f3 g\u00e2y nghi\u1ec7n kh\u00f4ng?<\/h2>\n

      Thu\u1ed1c Quelept 25mg (Quetiapin) kh\u00f4ng thu\u1ed9c nh\u00f3m thu\u1ed1c g\u00e2y nghi\u1ec7n hay c\u00e1c ch\u1ea5t g\u00e2y nghi\u1ec7n th\u00f4ng th\u01b0\u1eddng. Tuy nhi\u00ean, n\u1ebfu ng\u01b0\u1eddi b\u1ec7nh \u0111\u1ed9t ng\u1ed9t d\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c m\u00e0 kh\u00f4ng c\u00f3 l\u1ed9 tr\u00ecnh gi\u1ea3m li\u1ec1u th\u00edch h\u1ee3p, c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u00e1c ph\u1ea3n \u1ee9ng ng\u01b0ng thu\u1ed1c c\u1ea5p t\u00ednh nh\u01b0: m\u1ea5t ng\u1ee7 k\u00e9o d\u00e0i, c\u1ea3m gi\u00e1c bu\u1ed3n n\u00f4n, \u0111au nh\u1ee9c \u0111\u1ea7u, ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda, ch\u00f3ng m\u1eb7t nghi\u00eam tr\u1ecdng v\u00e0 tr\u1ea1ng th\u00e1i kh\u00f3 ch\u1ecbu trong ng\u01b0\u1eddi. Ch\u00ednh v\u00ec v\u1eady, vi\u1ec7c ng\u1eebng thu\u1ed1c b\u1eaft bu\u1ed9c ph\u1ea3i th\u1ef1c hi\u1ec7n gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb d\u01b0\u1edbi s\u1ef1 theo d\u00f5i c\u1ee7a y b\u00e1c s\u0129.<\/p>\n

      Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n

      Li\u1ec1u d\u00f9ng<\/h3>\n

      Li\u1ec1u v\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh<\/p>\n\n\n\n\n\n\n\n
      Ch\u1ec9 \u0111\u1ecbnh <\/strong><\/td>\nNg\u00e0y 1<\/strong><\/td>\nNg\u00e0y 2<\/strong><\/td>\nNg\u00e0y 3<\/strong><\/td>\nNg\u00e0y 4<\/strong><\/td>\nGiai \u0111o\u1ea1n ti\u1ebfp theo \/ Li\u1ec1u duy tr\u00ec<\/strong><\/td>\nS\u1ed1 l\u1ea7n d\u00f9ng\/ng\u00e0y<\/strong><\/td>\n<\/tr>\n
      T\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t<\/strong><\/td>\n50mg<\/td>\n50-100mg<\/td>\n300mg<\/td>\n300-400mg<\/td>\n300 – 450 mg\/ng\u00e0y<\/td>\nChia 2 – 3 l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n
      C\u01a1n h\u01b0ng c\u1ea3m l\u01b0\u1ee1ng c\u1ef1c<\/strong><\/td>\n100mg<\/td>\n200mg<\/td>\n300mg<\/td>\n400mg<\/td>\nT\u0103ng t\u1ed1i \u0111a 800mg \u1edf ng\u00e0y 6 (b\u01b0\u1edbc t\u0103ng kh\u00f4ng qu\u00e1 200mg). Li\u1ec1u duy tr\u00ec: 400 – 800mg\/ng\u00e0y<\/td>\nChia 2l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n
      Tr\u1ea7m c\u1ea3m l\u01b0\u1ee1ng c\u1ef1c<\/strong><\/td>\n50mg<\/td>\n100mg<\/td>\n200mg<\/td>\n300mg<\/td>\nNg\u00e0y 5 \u0111\u1ea1t 400mg; ng\u00e0y 8 \u0111\u1ea1t t\u1ed1i \u0111a 600mg n\u1ebfu c\u1ea7n<\/td>\nU\u1ed1ng 1 l\u1ea7n tr\u01b0\u1edbc khi \u0111i ng\u1ee7<\/td>\n<\/tr>\n
      D\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t l\u01b0\u1ee1ng c\u1ef1c<\/strong><\/td>\n–<\/td>\n–<\/td>\n–<\/td>\n–<\/td>\nGi\u1eef nguy\u00ean m\u1ee9c li\u1ec1u hi\u1ec7u qu\u1ea3 \u1edf \u0111\u1ee3t c\u1ea5p.\u00a0 \u0110i\u1ec1u ch\u1ec9nh: 300 – 800mg\/ng\u00e0y<\/td>\nChia 2 l\u1ea7n\/ng\u00e0y (\u01afu ti\u00ean li\u1ec1u th\u1ea5p nh\u1ea5t)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/p>\n\n\n\n\n\n\n\n
      \u0110\u1ed1i t\u01b0\u1ee3ng<\/strong><\/td>\nKhuy\u1ebfn c\u00e1o v\u00e0 hi\u1ec7u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng<\/strong><\/td>\n<\/tr>\n
      Ng\u01b0\u1eddi cao tu\u1ed5i<\/td>\nKh\u1edfi \u0111\u1ea7u li\u1ec1u th\u1ea5p h\u01a1n, t\u1ed1c \u0111\u1ed9 t\u0103ng li\u1ec1u ch\u1eadm h\u01a1n ng\u01b0\u1eddi tr\u1ebb. Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi > 65 tu\u1ed5i b\u1ecb tr\u1ea7m c\u1ea3m l\u01b0\u1ee1ng c\u1ef1c.<\/td>\n<\/tr>\n
      Ng\u01b0\u1eddi suy gan<\/td>\nB\u1eaft \u0111\u1ea7u v\u1edbi 25 mg\/ng\u00e0y. C\u00f3 th\u1ec3 n\u00e2ng d\u1ea7n t\u1eeb 25 – 50 mg\/ng\u00e0y t\u00f9y m\u1ee9c \u0111\u00e1p \u1ee9ng.<\/td>\n<\/tr>\n
      Ng\u01b0\u1eddi suy th\u1eadn<\/td>\nKh\u00f4ng c\u1ea7n thay \u0111\u1ed5i, s\u1eed d\u1ee5ng theo m\u1ee9c li\u1ec1u chu\u1ea9n c\u1ee7a ng\u01b0\u1eddi l\u1edbn.<\/td>\n<\/tr>\n
      Tr\u1ebb <18<\/td>\nKh\u00f4ng khuy\u1ebfn c\u00e1o<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n

      Vi\u00ean n\u00e9n Quelept 25mg<\/b> \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, b\u1ea5t th\u1eddi \u0111i\u1ec3m n\u00e0o<\/p>\n

      Ri\u00eang \u0111\u1ed1i v\u1edbi ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m l\u01b0\u1ee1ng c\u1ef1c, c\u1ea7n tu\u00e2n th\u1ee7 u\u1ed1ng thu\u1ed1c m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y tr\u01b0\u1edbc gi\u1edd \u0111i ng\u1ee7.<\/p>\n

      Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Quelept 25mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n

      Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi ho\u1ea1t ch\u1ea5t Quetiapin fumarat ho\u1eb7c m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong vi\u00ean thu\u1ed1c<\/p>\n

      Ph\u1ed1i h\u1ee3p \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ho\u1ea1t ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh h\u1ec7 enzym cytochrom P450 3A4<\/p>\n

      L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n

      Th\u1eadn tr\u1ecdng<\/h3>\n

      N\u00ean gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd di\u1ec5n bi\u1ebfn t\u00e2m l\u00fd c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u00f3m c\u00f3 ti\u1ec1n s\u1eed ti\u00eau c\u1ef1c tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u li\u1ec7u tr\u00ecnh.<\/p>\n

      N\u00ean \u0111i \u0111\u1ee9ng, v\u1eadn \u0111\u1ed9ng c\u1ea9n tr\u1ecdng (nh\u1ea5t l\u00e0 ng\u01b0\u1eddi gi\u00e0) do thu\u1ed1c d\u1ec5 g\u00e2y ch\u00f3ng m\u1eb7t, ng\u1ee7 g\u00e0 v\u00e0 t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u<\/p>\n

      Kh\u00f4ng n\u00ean t\u1ef1 \u00fd t\u0103ng li\u1ec1u n\u1ebfu c\u01a1 th\u1ec3 xu\u1ea5t hi\u1ec7n tr\u1ea1ng th\u00e1i b\u1ee9t r\u1ee9t, n\u1eb1m ng\u1ed3i kh\u00f4ng y\u00ean trong v\u00e0i tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n

      Ng\u1eebng thu\u1ed1c theo ch\u1ec9 d\u1eabn v\u00e0 l\u1ed9 tr\u00ecnh \u0111\u01b0a ra ph\u1ea3i do b\u00e1c s\u0129, kh\u00f4ng t\u1ef1 \u00fd d\u1eebng \u0111\u1ed9t ng\u1ed9t, n\u00ean gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb trong t\u1ed1i thi\u1ec3u 1 – 2 tu\u1ea7n \u0111\u1ec3 tr\u00e1nh h\u1ed9i ch\u1ee9ng cai thu\u1ed1c.<\/p>\n

      N\u00ean \u0111\u1eb7c bi\u1ec7t th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao b\u1ecb s\u1eb7c ho\u1eb7c kh\u00f3 nu\u1ed1t.<\/p>\n

      Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c n\u00e0y \u0111\u1ec3 ch\u1eefa tr\u1ecb ch\u1ee9ng lo\u1ea1n t\u00e2m th\u1ea7n do m\u1ea5t tr\u00ed nh\u1edb \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n

      N\u00ean th\u1eadn tr\u1ecdng t\u1ed1i \u0111a khi d\u00f9ng cho ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9ng kinh, t\u1ed5n th\u01b0\u01a1ng m\u1ea1ch m\u00e1u n\u00e3o ho\u1eb7c suy tim sung huy\u1ebft.<\/p>\n

      Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c cho ng\u01b0\u1eddi b\u1ecb l\u1ed7i h\u1ea5p thu glucose-galactose, thi\u1ebfu h\u1ee5t Lapp-lactase ho\u1eb7c kh\u00f4ng dung n\u1ea1p galactose b\u1ea9m sinh do c\u00f4ng th\u1ee9c c\u00f3 ch\u1ee9a t\u00e1 d\u01b0\u1ee3c lactose.<\/p>\n

      T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n

      R\u1ea5t th\u01b0\u1eddng g\u1eb7p: Bi\u1ebfn \u0111\u1ed9ng ch\u1ec9 s\u1ed1 m\u1ee1 m\u00e1u (nh\u01b0 t\u0103ng cholesterol hay triglycerid), t\u0103ng c\u00e2n, kh\u00f4 mi\u1ec7ng, \u0111au nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng v\u00e1ng \u0111\u1ea7u \u00f3c v\u00e0 bu\u1ed3n ng\u1ee7.<\/p>\n

      Th\u01b0\u1eddng g\u1eb7p: Xu\u1ea5t hi\u1ec7n c\u00e1c gi\u1ea5c m\u01a1 b\u1ea5t th\u01b0\u1eddng, t\u0103ng c\u1ea3m gi\u00e1c th\u00e8m \u0103n, t\u0103ng men gan, ti\u00eau h\u00f3a k\u00e9m, t\u00e1o b\u00f3n, h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, nh\u1ecbp tim \u0111\u1eadp nhanh v\u00e0 s\u1ee5t gi\u1ea3m l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u.<\/p>\n

      \u00cdt g\u1eb7p: G\u1eb7p kh\u00f3 kh\u0103n khi nu\u1ed1t, k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3, ph\u00e1t sinh h\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng ngh\u1ec9, xu\u1ea5t hi\u1ec7n c\u00e1c c\u01a1n co gi\u1eadt \u0111\u1ed9ng kinh, suy gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u.<\/p>\n

      Hi\u1ebfm g\u1eb7p: M\u1eafc h\u1ed9i ch\u1ee9ng u th\u1ea7n kinh \u00e1c t\u00ednh, huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch, m\u1ed9ng du, vi\u00eam gan, v\u00e0ng da, vi\u00eam t\u1ee5y v\u00e0 bi\u1ebfn ch\u1ee9ng m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t.<\/p>\n

      R\u1ea5t hi\u1ebfm g\u1eb7p: Kh\u1edfi ph\u00e1t h\u1ed9i ch\u1ee9ng ho\u1ea1i t\u1eed da Stevens-Johnson, ph\u00f9 m\u1ea1ch, bi\u1ebfn ch\u1ee9ng ti\u00eau c\u01a1 v\u00e2n ho\u1eb7c s\u1ed1c ph\u1ea3n v\u1ec7 nguy hi\u1ec3m.<\/p>\n

      T\u01b0\u01a1ng t\u00e1c<\/h3>\n

      Ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 (nh\u01b0 ketoconazol, erythromycin, fluconazol): L\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 quetiapin trong m\u00e1u.<\/p>\n

      Ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 (nh\u01b0 phenytoin, carbamazepin, rifampin): L\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 quetiapin; c\u1ea7n c\u0103n ch\u1ec9nh li\u1ec1u khi ph\u1ed1i h\u1ee3p ho\u1eb7c d\u1eebng thu\u1ed1c.<\/p>\n

      Phenytoin: K\u00edch th\u00edch t\u0103ng thanh th\u1ea3i quetiapin g\u1ea5p 5 l\u1ea7n (\u0111\u00f2i h\u1ecfi t\u0103ng li\u1ec1u quetiapin); n\u00ean thay b\u1eb1ng valproat n\u1ebfu ng\u01b0ng phenytoin.<\/p>\n

      Thioridazin: \u0110\u1ea5y nhanh t\u1ed1c \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a quetiapin qua \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n

      Cimetidin: L\u00e0m gi\u1ea3m kho\u1ea3ng 20% \u0111\u1ed9 thanh th\u1ea3i quetiapin nh\u01b0ng l\u00e2m s\u00e0ng kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u.<\/p>\n

      Lorazepam: B\u1ecb gi\u1ea3m kho\u1ea3ng 20% \u0111\u1ed9 thanh th\u1ea3i trung b\u00ecnh khi d\u00f9ng chung.<\/p>\n

      R\u01b0\u1ee3u, bia, \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n: L\u00e0m t\u0103ng m\u1ea1nh t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng; c\u1ea7n tr\u00e1nh s\u1eed d\u1ee5ng.<\/p>\n

      Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p: L\u00e0m c\u1ed9ng h\u01b0\u1edfng v\u00e0 gia t\u0103ng hi\u1ec7u \u1ee9ng h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n

      Levodopa v\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng dopamin: G\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u1ed1i kh\u00e1ng l\u1eabn nhau.<\/p>\n

      C\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng th\u1ea7n kinh kh\u00e1c: L\u00e0m t\u0103ng c\u01b0\u1eddng \u0111\u1ed9c t\u00ednh ho\u1eb7c t\u00e1c d\u1ee5ng l\u00ean h\u1ec7 th\u1ea7n kinh.<\/p>\n

      L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n

      \u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef \u0111ang mang thai c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1eabn ch\u01b0a thi\u1ebft l\u1eadp \u0111\u1ea7y \u0111\u1ee7 v\u00e0 x\u00e1c \u0111\u1ecbnh r\u00f5 r\u00e0ng m\u1ee9c \u0111\u1ed9 an to\u00e0n c\u0169ng nh\u01b0 t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a ho\u1ea1t ch\u1ea5t quetiapin \u0111\u1ed1i v\u1edbi thai ph\u1ee5. V\u00ec v\u1eady, nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y ch\u1ec9 \u0111\u01b0\u1ee3c ph\u00e9p s\u1eed d\u1ee5ng thu\u1ed1c Quelept 25mg khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh b\u1eaft bu\u1ed9c t\u1eeb b\u00e1c s\u0129<\/p>\n

      \u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef \u0111ang nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9 d\u00f9 ho\u1ea1t ch\u1ea5t quetiapin c\u00f3 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 nh\u01b0ng v\u1edbi m\u1ed9t h\u00e0m l\u01b0\u1ee3ng t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p. M\u1eb7c d\u00f9 v\u1eady, v\u1eabn khuy\u1ebfn c\u00e1o l\u00e0 n\u00ean tr\u00e1nh vi\u1ec7c cho con b\u00fa.<\/p>\n

      L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n

      Do c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a thu\u1ed1c t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp v\u00e0 ch\u1ee7 y\u1ebfu l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra tr\u1ea1ng th\u00e1i ng\u1ee7 g\u00e0, bu\u1ed3n ng\u1ee7 s\u00e2u v\u00e0 l\u00e0m suy gi\u1ea3m nghi\u00eam tr\u1ecdng kh\u1ea3 n\u0103ng t\u1ec9nh t\u00e1o c\u1ee7a ng\u01b0\u1eddi d\u00f9ng. Do \u0111\u00f3, trong th\u1eddi gian d\u00f9ng thu\u1ed1c, ng\u01b0\u1eddi b\u1ec7nh tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y<\/p>\n

      Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n

      Tri\u1ec7u ch\u1ee9ng: Bu\u1ed3n ng\u1ee7, an th\u1ea7n s\u00e2u, nh\u1ecbp tim \u0111\u1eadp nhanh, h\u1ea1 huy\u1ebft \u00e1p, k\u00e9o d\u00e0i kho\u1ea3ng QT, co gi\u1eadt, l\u00fa l\u1eabn, k\u00edch \u0111\u1ed9ng, m\u00ea s\u1ea3ng, tr\u1ea1ng th\u00e1i \u0111\u1ed9ng kinh, suy h\u00f4 h\u1ea5p, ti\u00eau c\u01a1 v\u00e2n v\u00e0 b\u00ed ti\u1ec3u (nguy c\u01a1 bi\u1ebfn ch\u1ee9ng cao h\u01a1n \u1edf ng\u01b0\u1eddi c\u00f3 b\u1ec7nh tim m\u1ea1ch).<\/p>\n

      X\u1eed tr\u00ed:<\/p>\n