{"id":148934,"date":"2025-11-24T08:36:22","date_gmt":"2025-11-24T01:36:22","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=148934"},"modified":"2025-11-24T08:41:22","modified_gmt":"2025-11-24T01:41:22","slug":"encorate-300","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/encorate-300\/","title":{"rendered":"Encorate 300"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Encorate 300 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi <\/b>Sun Pharmaceutical Industries Ltd <b>c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 890114040825 (S\u0110K c\u0169: VN-16380-13)<\/b><\/p>\n<h2>Encorate 300 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Encorate 300<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Sodium Valproate BP 300mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c g\u1ed3m: Colloidal anhydrous silica, Microcrystalline cellulose (pH 101), tinh b\u1ed9t ng\u00f4, Povidone (K30), Calcium silicate, Magnesium stearate, Talc, Sodium starch glycolate, Hypromellose 2910, Dibutyl Phthalate, Eudragit L100-55, Titanium dioxide, Ponceau 4R Lake, Sunset Yellow Lake.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim tan trong ru\u1ed9t<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 890114040825 (S\u0110K c\u0169: VN-16380-13)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Encorate 300<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Sodium Valproate t\u1ea1o hi\u1ec7u qu\u1ea3 ch\u1ed1ng \u0111\u1ed9ng kinh th\u00f4ng qua vi\u1ec7c l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh c\u1ee7a h\u1ec7 d\u1eabn truy\u1ec1n \u1ee9c ch\u1ebf GABA. Thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh v\u00e0 chuy\u1ec3n h\u00f3a ch\u1ea5t n\u00e0y, t\u1eeb \u0111\u00f3 gi\u00fap gi\u1ea3m s\u1ef1 ph\u00f3ng \u0111i\u1ec7n b\u1ea5t th\u01b0\u1eddng c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Th\u1eddi gian th\u1ea3i tr\u1eeb c\u1ee7a Sodium Valproate dao \u0111\u1ed9ng kho\u1ea3ng 8\u201320 gi\u1edd, v\u00e0 tr\u1ebb em th\u01b0\u1eddng c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y ng\u1eafn h\u01a1n. N\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng c\u1ea7n thi\u1ebft \u0111\u1ec3 t\u1ea1o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb r\u01a1i v\u00e0o kho\u1ea3ng 40\u2013100 mg\/l (278\u2013694 \u03bcmol\/l), nh\u01b0ng m\u1ee9c \u0111\u1ed9 n\u00e0y c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u00f9y b\u1ec7nh nh\u00e2n v\u00e0 thu\u1ed1c ph\u1ed1i h\u1ee3p. Kho\u1ea3ng 6\u201315% thu\u1ed1c t\u1ed3n t\u1ea1i d\u01b0\u1edbi d\u1ea1ng t\u1ef1 do trong m\u00e1u.<\/p>\n<h2>Thu\u1ed1c Encorate 300 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb c\u00e1c d\u1ea1ng \u0111\u1ed9ng kinh to\u00e0n th\u1ec3, c\u1ee5c b\u1ed9 ho\u1eb7c nh\u1eefng th\u1ec3 \u0111\u1ed9ng kinh kh\u00e1c theo \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng.<\/p>\n<p>D\u00f9ng cho ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n ch\u1ec9 khi b\u1ec7nh n\u1eb7ng ho\u1eb7c kh\u00f4ng c\u00f2n \u0111\u00e1p \u1ee9ng v\u1edbi nh\u1eefng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh kh\u00e1c.<\/p>\n<p>Ph\u00f2ng ng\u1eeba s\u1ed1t cao co gi\u1eadt \u1edf tr\u1ebb nh\u1ecf, \u0111i\u1ec1u tr\u1ecb gi\u1eadt c\u01a1 \u1edf tr\u1ebb em.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u0169ng nh\u01b0 d\u1ef1 ph\u00f2ng c\u01a1n h\u01b0ng c\u1ea3m trong r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/p>\n<figure id=\"attachment_148935\" aria-describedby=\"caption-attachment-148935\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-148935 size-full\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300.jpg\" alt=\"Encorate 300\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/11\/Encorate-300-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-148935\" class=\"wp-caption-text\">Thu\u1ed1c Encorate 300 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><b><i>Ng\u01b0\u1eddi l\u1edbn<\/i><\/b><\/p>\n<p>Kh\u1edfi \u0111\u1ea7u 600 mg\/ng\u00e0y, chia nhi\u1ec1u l\u1ea7n.<\/p>\n<p>T\u0103ng th\u00eam 200 mg m\u1ed7i 3 ng\u00e0y cho \u0111\u1ebfn khi ki\u1ec3m so\u00e1t c\u01a1n; th\u01b0\u1eddng d\u00f9ng 1.000\u20132.000 mg\/ng\u00e0y.<\/p>\n<p>N\u1ebfu ch\u01b0a ki\u1ec3m so\u00e1t t\u1ed1t c\u00f3 th\u1ec3 t\u0103ng t\u1ed1i \u0111a \u0111\u1ebfn 2.500 mg\/ng\u00e0y.<\/p>\n<p><b><i>Tr\u1ebb em &gt; 20 kg<\/i><\/b><\/p>\n<p>B\u1eaft \u0111\u1ea7u 400 mg\/ng\u00e0y.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 th\u01b0\u1eddng \u0111\u1ea1t \u1edf m\u1ee9c 20\u201330 mg\/kg\/ng\u00e0y; khi c\u1ea7n c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 35 mg\/kg\/ng\u00e0y.<\/p>\n<p><b><i>Tr\u1ebb em &lt; 20 kg<\/i><\/b><\/p>\n<p>Li\u1ec1u chu\u1ea9n 20 mg\/kg\/ng\u00e0y.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u nh\u01b0ng ch\u1ec9 khi c\u00f3 theo d\u00f5i ch\u1eb7t n\u1ed3ng \u0111\u1ed9 acid valproic trong m\u00e1u.<\/p>\n<p><b><i>Ng\u01b0\u1eddi cao tu\u1ed5i<\/i><\/b><\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc thay \u0111\u1ed5i theo tu\u1ed5i nh\u01b0ng tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng th\u01b0\u1eddng \u00edt bi\u1ebfn \u0111\u1ed5i; vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u n\u00ean d\u1ef1a tr\u00ean m\u1ee9c ki\u1ec3m so\u00e1t c\u01a1n.<\/p>\n<p><b><i>Suy th\u1eadn<\/i><\/b><\/p>\n<p>C\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u.<\/p>\n<p>D\u1ef1a ho\u00e0n to\u00e0n v\u00e0o n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 sai l\u1ec7ch; \u01b0u ti\u00ean \u0111\u00e1nh gi\u00e1 \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng.<\/p>\n<p>Tr\u1ebb d\u00f9ng li\u1ec1u &gt; 40 mg\/kg\/ng\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i huy\u1ebft h\u1ecdc v\u00e0 sinh h\u00f3a ch\u1eb7t ch\u1ebd.<\/p>\n<p><b><i>\u0110i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh kh\u00e1c<\/i><\/b><\/p>\n<p>Khi b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111ang d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh kh\u00e1c, c\u1ea7n t\u0103ng li\u1ec1u valproate t\u1eeb t\u1eeb trong kho\u1ea3ng 2 tu\u1ea7n.<\/p>\n<p>C\u00f3 th\u1ec3 t\u0103ng th\u00eam 5\u201310 mg\/kg\/ng\u00e0y khi ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c c\u1ea3m \u1ee9ng men (phenytoin, carbamazepine, phenobarbital).<\/p>\n<p>Sau khi ng\u1eebng thu\u1ed1c c\u1ea3m \u1ee9ng men, valproate c\u00f3 th\u1ec3 duy tr\u00ec hi\u1ec7u qu\u1ea3 \u1edf li\u1ec1u th\u1ea5p h\u01a1n.<\/p>\n<p>N\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi barbiturate v\u00e0 xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng an th\u1ea7n, c\u1ea7n c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u barbiturate<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Vi\u00ean Encorate 300 \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng<\/p>\n<p>Vi\u00ean bao tan trong ru\u1ed9t c\u1ea7n \u0111\u01b0\u1ee3c d\u00f9ng nguy\u00ean vi\u00ean<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Encorate 300 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Natri Valproate c\u00f3 trong <strong>Encorate 300<\/strong><\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh gan c\u1ea5p ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed suy gan n\u1eb7ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c th\u1ec3 vi\u00eam gan do thu\u1ed1c ho\u1eb7c r\u1ed1i lo\u1ea1n porphyrin chuy\u1ec3n h\u00f3a.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u, m\u1ed9t ph\u1ea7n \u1edf d\u1ea1ng ketone, c\u00f3 th\u1ec3 t\u1ea1o k\u1ebft qu\u1ea3 d\u01b0\u01a1ng gi\u1ea3 khi x\u00e9t nghi\u1ec7m \u0111\u01b0\u1eddng ni\u1ec7u \u1edf ng\u01b0\u1eddi \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>\u0110\u00e3 ghi nh\u1eadn c\u00e1c tr\u01b0\u1eddng h\u1ee3p suy gan n\u1eb7ng, \u0111\u00f4i khi d\u1eabn \u0111\u1ebfn t\u1eed vong, th\u01b0\u1eddng g\u1eb7p \u1edf tr\u1ebb nh\u1ecf d\u01b0\u1edbi 3 tu\u1ed5i ho\u1eb7c tr\u1ebb c\u00f3 b\u1ec7nh di truy\u1ec1n, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a, n\u00e3o b\u1ed9 t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c \u0111\u1ed9ng kinh n\u1eb7ng k\u00e8m ch\u1eadm ph\u00e1t tri\u1ec3n.<\/p>\n<p>C\u1ea7n ki\u1ec3m tra ch\u1ee9c n\u0103ng gan tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ecbnh k\u1ef3 m\u1ed7i 6 th\u00e1ng, \u0111\u1eb7c bi\u1ec7t v\u1edbi nh\u00f3m b\u1ec7nh nh\u00e2n nguy c\u01a1 cao.<\/p>\n<p>Ng\u1eebng thu\u1ed1c n\u1ebfu th\u1eddi gian prothrombin k\u00e9o d\u00e0i b\u1ea5t th\u01b0\u1eddng ho\u1eb7c k\u00e8m nh\u1eefng r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u kh\u00e1c.<\/p>\n<p>Khi xu\u1ea5t hi\u1ec7n t\u0103ng amoniac m\u00e1u c\u00f9ng c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 n\u00f4n, m\u1ea5t \u0111i\u1ec1u h\u00f2a, thay \u0111\u1ed5i \u00fd th\u1ee9c ph\u1ea3i d\u1eebng thu\u1ed1c.<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o vi\u00eam t\u1ee5y, \u0111\u00f4i khi r\u1ea5t n\u1eb7ng; n\u1ebfu \u0111au b\u1ee5ng c\u1ea5p k\u00e8m t\u0103ng amylase c\u1ea7n d\u1eebng \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, l\u00e0m k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u v\u00e0 gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u; c\u00e1c t\u00ecnh tr\u1ea1ng n\u00e0y li\u00ean quan \u0111\u1ebfn li\u1ec1u v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng h\u1ed3i ph\u1ee5c.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Gan: v\u00e0ng da, \u0111au b\u1ee5ng, ch\u00e1n \u0103n, bu\u1ed3n n\u00f4n; nh\u1eefng tr\u01b0\u1eddng h\u1ee3p suy gan n\u1eb7ng c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n nguy hi\u1ec3m.<\/p>\n<p>Th\u1ea7n kinh: run, th\u1ea5t \u0111i\u1ec1u, ng\u1ee7 g\u00e0, l\u00fa l\u1eabn, k\u00edch \u0111\u1ed9ng, \u1ea3o gi\u00e1c; hi\u1ebfm g\u1eb7p h\u01a1n l\u00e0 vi\u00eam n\u00e3o, h\u00f4n m\u00ea ho\u1eb7c r\u1ed1i lo\u1ea1n tr\u00ed nh\u1edb c\u00f3 h\u1ed3i ph\u1ee5c.<\/p>\n<p>Ti\u00eau h\u00f3a: kh\u00f3 ch\u1ecbu d\u1ea1 d\u00e0y \u2013 ru\u1ed9t, \u0111\u00f4i khi t\u0103ng c\u1ea3m gi\u00e1c th\u00e8m \u0103n ho\u1eb7c t\u0103ng c\u00e2n.<\/p>\n<p>Da: r\u1ee5ng t\u00f3c tho\u00e1ng qua; r\u1ea5t hi\u1ebfm g\u1eb7p ph\u1ea3n \u1ee9ng n\u1eb7ng nh\u01b0 ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec, h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson ho\u1eb7c ban \u0111\u1ecf.<\/p>\n<p>Huy\u1ebft h\u1ecdc: gi\u1ea3m t\u1ebf b\u00e0o m\u00e1u, gi\u1ea3m fibrinogen, t\u0103ng amoniac m\u00e1u, ph\u00f9, vi\u00eam t\u1ee5y, c\u00e1c r\u1ed1i lo\u1ea1n hi\u1ebfm g\u1eb7p kh\u00e1c.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Valproate \u00edt g\u00e2y c\u1ea3m \u1ee9ng men, kh\u00f4ng l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 thu\u1ed1c tr\u00e1nh thai.<\/p>\n<p>C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c an th\u1ea7n, ch\u1ed1ng tr\u1ea7m c\u1ea3m, thu\u1ed1c \u1ee9c ch\u1ebf monoamin ho\u1eb7c benzodiazepin.<\/p>\n<p>T\u0103ng n\u1ed3ng \u0111\u1ed9 phenobarbital v\u00e0 primidone, d\u1ec5 g\u00e2y an th\u1ea7n \u2192 c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u.<\/p>\n<p>L\u00e0m t\u0103ng d\u1ea1ng t\u1ef1 do c\u1ee7a phenytoin v\u00e0 t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a carbamazepine.<\/p>\n<p>Lamotrigine b\u1ecb k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n h\u1ee7y \u2192 c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Zidovudine c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 g\u00e2y \u0111\u1ed9c.<\/p>\n<p>Warfarin v\u00e0 c\u00e1c thu\u1ed1c nh\u00f3m coumarin c\u00f3 th\u1ec3 gi\u1ea3m g\u1eafn k\u1ebft protein \u2192 theo d\u00f5i th\u1eddi gian prothrombin.<\/p>\n<p>Aspirin v\u00e0 c\u00e1c salicylate c\u00f3 th\u1ec3 \u0111\u1ea9y valproate kh\u1ecfi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Cimetidine, erythromycin l\u00e0m gi\u1ea3m th\u1ea3i tr\u1eeb valproate.<\/p>\n<p>Mefloquine t\u0103ng chuy\u1ec3n h\u00f3a valproate v\u00e0 c\u00f3 th\u1ec3 g\u00e2y co gi\u1eadt.<\/p>\n<p>Cholestyramine l\u00e0m gi\u1ea3m h\u1ea5p thu thu\u1ed1c.<\/p>\n<p>Felbamate c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 valproate.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p><b><i>Ph\u1ee5 n\u1eef c\u00f3 thai<\/i><\/b><\/p>\n<p>Ghi nh\u1eadn t\u1ec9 l\u1ec7 d\u1ecb t\u1eadt b\u1ea9m sinh t\u0103ng, g\u1ed3m b\u1ea5t th\u01b0\u1eddng khu\u00f4n m\u1eb7t, d\u1ecb t\u1eadt x\u01b0\u01a1ng (\u0111\u1eb7c bi\u1ec7t x\u01b0\u01a1ng \u0111\u00f9i) v\u00e0 khuy\u1ebft t\u1eadt \u1ed1ng th\u1ea7n kinh \u1edf tr\u1ebb sinh ra t\u1eeb m\u1eb9 d\u00f9ng valproate.<\/p>\n<p>Nguy c\u01a1 khuy\u1ebft t\u1eadt \u1ed1ng th\u1ea7n kinh \u01b0\u1edbc kho\u1ea3ng 1\u20132% khi s\u1eed d\u1ee5ng trong 3 th\u00e1ng \u0111\u1ea7u.<\/p>\n<p>B\u1ed5 sung folate gi\u00fap gi\u1ea3m nguy c\u01a1 nh\u01b0ng kh\u00f4ng lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n.<\/p>\n<p>C\u1ea7n d\u00f9ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 th\u1ec3, chia li\u1ec1u nhi\u1ec1u l\u1ea7n.<\/p>\n<p>Theo d\u00f5i \u0111\u00f4ng m\u00e1u v\u00e0 fibrinogen \u1edf tr\u1ebb s\u01a1 sinh v\u00ec c\u00f3 th\u1ec3 x\u1ea3y ra h\u1ed9i ch\u1ee9ng xu\u1ea5t huy\u1ebft.<\/p>\n<p><b><i>Cho con b\u00fa<\/i><\/b><\/p>\n<p>N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong s\u1eefa r\u1ea5t th\u1ea5p (1\u20132% n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng).<\/p>\n<p>Kh\u00f4ng c\u00f3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh tuy\u1ec7t \u0111\u1ed1i; quy\u1ebft \u0111\u1ecbnh cho b\u00fa t\u00f9y thu\u1ed9c \u0111\u00e1nh gi\u00e1 l\u1ee3i \u00edch \u2013 nguy c\u01a1.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>M\u1ed9t s\u1ed1 r\u1ed3i lo\u1ea1n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng l\u00e0m vi\u1ec7c nh\u01b0 bu\u1ed3n ng\u1ee7, gi\u1ea3m t\u1ec9nh t\u00e1o c\u00f3 th\u1ec3 x\u1ea3y ra, c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Khi n\u1ed3ng \u0111\u1ed9 trong m\u00e1u v\u01b0\u1ee3t 5\u20136 l\u1ea7n m\u1ee9c \u0111i\u1ec1u tr\u1ecb, th\u01b0\u1eddng ch\u1ec9 g\u1eb7p bu\u1ed3n n\u00f4n, n\u00f4n v\u00e0 ch\u00f3ng m\u1eb7t.<\/p>\n<p>N\u1ebfu qu\u00e1 li\u1ec1u \u1edf m\u1ee9c 10\u201320 l\u1ea7n, c\u00f3 th\u1ec3 g\u00e2y \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng nghi\u00eam tr\u1ecdng, suy h\u00f4 h\u1ea5p v\u00e0 m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p v\u1eabn c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u01a1n \u0111\u1ed9ng kinh.<\/p>\n<p>X\u1eed tr\u00ed t\u1ea1i b\u1ec7nh vi\u1ec7n g\u1ed3m r\u1eeda d\u1ea1 d\u00e0y, ki\u1ec3m so\u00e1t n\u00f4n, h\u1ed7 tr\u1ee3 h\u00f4 h\u1ea5p v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 truy\u1ec1n ho\u1eb7c l\u1ecdc m\u00e1u<\/p>\n<p>C\u00f3 th\u1ec3 t\u1eed vong n\u1ebfu qu\u00e1 li\u1ec1u Encorate 300 n\u1eb7ng<\/p>\n<p>Naloxone ti\u00eam t\u0129nh m\u1ea1ch t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi than ho\u1ea1t \u0111\u01b0\u1eddng u\u1ed1ng trong m\u1ed9t s\u1ed1 ca.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Encorate 300 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Encorate 300 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Encorate 300 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Encorate 300 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/valparin-200-alkalets\/\">Valparin-200 Alkalets<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Natri valproate 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Torrent Pharmaceuticals Ltd, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/encorate-200mg\/\">Encorate 200mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Natri valproate 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Sun Pharmaceutical Industries Ltd, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Encorate 300 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 t\u1ea1i \u0111\u00e2y. Truy c\u1eadp ng\u00e0y 24 th\u00e1ng 11 n\u0103m 2025.<\/li>\n<li>Pinder RM, Brogden RN, Speight TM, Avery GS. Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs. Truy c\u1eadp ng\u00e0y 24 th\u00e1ng 11 n\u0103m 2025 t\u1eeb: <a style=\"font-size: 14.4px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/402258\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/402258\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Encorate 300 l\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh ch\u1ee9a ho\u1ea1t ch\u1ea5t ch\u00ednh Sodium Valproate, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t nhi\u1ec1u d\u1ea1ng c\u01a1n \u0111\u1ed9ng kinh v\u00e0 m\u1ed9t s\u1ed1 r\u1ed1i lo\u1ea1n li\u00ean quan<\/p>\n","protected":false},"author":1,"featured_media":148939,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-148934","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/148934","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=148934"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/148939"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=148934"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=148934"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=148934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}