{"id":146711,"date":"2025-10-31T09:49:48","date_gmt":"2025-10-31T02:49:48","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=146711"},"modified":"2025-10-31T09:51:50","modified_gmt":"2025-10-31T02:51:50","slug":"co-padein-500-10","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/co-padein-500-10\/","title":{"rendered":"Co-Padein 500\/10"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong><a href=\"https:\/\/vnras.com\/drug\/\"><strong> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n Thu\u1ed1c Co-Padein 500\/10 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi NADYPHAR, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-17867-12<\/strong><\/p>\n<h2>Thu\u1ed1c Co-Padein 500\/10 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i vi\u00ean Thu\u1ed1c <strong>Co-Padein 500\/10 <\/strong>c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Paracetamol:500mg<\/li>\n<li>Codein: 10mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-17867-12<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 V\u1ec9 x 10 Vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_146712\" aria-describedby=\"caption-attachment-146712\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-146712\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4.jpg\" alt=\"Thu\u1ed1c Co-Padein 500\/10 gi\u00fap gi\u1ea3m \u0111au c\u1ea5p t\u00ednh m\u1ee9c \u0111\u1ed9 trung b\u00ecnh\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Co-Padein-500-10-4-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-146712\" class=\"wp-caption-text\">Thu\u1ed1c Co-Padein 500\/10 gi\u00fap gi\u1ea3m \u0111au c\u1ea5p t\u00ednh m\u1ee9c \u0111\u1ed9 trung b\u00ecnh<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a Thu\u1ed1c Co-Padein 500\/10<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p><strong>Paracetamol <\/strong>l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t t\u1ed5ng h\u1ee3p thu\u1ed9c nh\u00f3m d\u1eabn xu\u1ea5t c\u1ee7a p-aminophenol. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a Paracetamol t\u01b0\u01a1ng t\u1ef1 acid salicylic tuy nhi\u00ean Paracetamol kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng vi\u00eam hay ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. Paracetamol gi\u00fap gi\u1ea3m nhi\u1ec7t \u0111\u1ed9 c\u01a1 th\u1ec3 khi b\u1ecb s\u1ed1t b\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean trung t\u00e2m \u0111i\u1ec1u nhi\u1ec7t v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i, th\u00fac \u0111\u1ea9y gi\u00e3n m\u1ea1ch v\u00e0 t\u0103ng l\u01b0u th\u00f4ng m\u00e1u ngo\u1ea1i bi\u00ean, qua \u0111\u00f3 t\u0103ng t\u1ecfa nhi\u1ec7t.<\/p>\n<p>Codein l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, ho\u1ea1t t\u00ednh y\u1ebfu v\u00e0 g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 opioid. Hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au ch\u1ee7 y\u1ebfu do codein \u0111\u01b0\u1ee3c gan chuy\u1ec3n h\u00f3a th\u00e0nh morphin. Khi ph\u1ed1i h\u1ee3p v\u1edbi paracetamol, t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng r\u00f5 r\u1ec7t, \u0111\u1eb7c bi\u1ec7t v\u1edbi c\u00e1c c\u01a1n \u0111au c\u1ea5p t\u00ednh do th\u1ea7n kinh c\u1ea3m th\u1ee5.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Paracetamol: \u0111\u01b0\u1ee3c h\u1ea5p thu g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 30 \u0111\u1ebfn 60 ph\u00fat. Sau khi v\u00e0o c\u01a1 th\u1ec3, thu\u1ed1c ph\u00e2n b\u1ed1 nhanh \u0111\u1ebfn h\u1ea7u h\u1ebft c\u00e1c m\u00f4, kho\u1ea3ng m\u1ed9t ph\u1ea7n t\u01b0 l\u01b0\u1ee3ng thu\u1ed1c g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Paracetamol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu t\u1ea1i gan, th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh t\u1eeb 1,25 \u0111\u1ebfn 3 gi\u1edd nh\u01b0ng c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi b\u1ec7nh gan ho\u1eb7c khi d\u00f9ng li\u1ec1u cao. Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng li\u00ean h\u1ee3p v\u1edbi acid glucuronic, acid sulfuric v\u00e0 cystein; ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u1ea1ng kh\u00f4ng \u0111\u1ed5i.<\/p>\n<p>Codein: h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, b\u1eaft \u0111\u1ea7u c\u00f3 t\u00e1c d\u1ee5ng trong kho\u1ea3ng 1 \u0111\u1ebfn 2 gi\u1edd v\u00e0 k\u00e9o d\u00e0i 4 \u0111\u1ebfn 6 gi\u1edd. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 2 \u0111\u1ebfn 4 gi\u1edd. Codein \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan, b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng t\u1ef1 do ho\u1eb7c li\u00ean h\u1ee3p. Thu\u1ed1c c\u00f3 th\u1ec3 \u0111i qua nhau thai v\u00e0 m\u1ed9t ph\u1ea7n qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o.<\/p>\n<h2>Thu\u1ed1c Co-Padein 500\/10 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c Co-Padein 500\/10 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 gi\u1ea3m \u0111au c\u1ea5p t\u00ednh m\u1ee9c \u0111\u1ed9 trung b\u00ecnh \u1edf ng\u01b0\u1eddi t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean, trong tr\u01b0\u1eddng h\u1ee3p c\u00e1c thu\u1ed1c gi\u1ea3m \u0111au \u0111\u01a1n thu\u1ea7n nh\u01b0 paracetamol ho\u1eb7c ibuprofen kh\u00f4ng c\u00f2n hi\u1ec7u qu\u1ea3.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh d\u00f9ng t\u1eeb 1 \u0111\u1ebfn 2 vi\u00ean m\u1ed7i l\u1ea7n, l\u1eb7p l\u1ea1i sau 4 \u0111\u1ebfn 6 gi\u1edd n\u1ebfu c\u1ea7n, nh\u01b0ng kh\u00f4ng qu\u00e1 8 vi\u00ean trong 24 gi\u1edd.<\/p>\n<p>Tr\u1ebb em t\u1eeb 12 \u0111\u1ebfn 18 tu\u1ed5i d\u00f9ng li\u1ec1u t\u01b0\u01a1ng t\u1ef1, m\u1ed7i 6 gi\u1edd m\u1ed9t l\u1ea7n, t\u1ed1i \u0111a 8 vi\u00ean m\u1ed7i ng\u00e0y.<\/p>\n<p>Kh\u00f4ng d\u00f9ng thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i do nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c opioid do chuy\u1ec3n h\u00f3a codein th\u00e0nh morphin kh\u00f3 d\u1ef1 \u0111o\u00e1n.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i kh\u00f4ng c\u1ea7n thay \u0111\u1ed5i li\u1ec1u, tuy nhi\u00ean c\u1ea7n gi\u1ea3m li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Thu\u1ed1c Co-Padein 500\/10 d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng Thu\u1ed1c Co-Padein 500\/10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Kh\u00f4ng d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o, tr\u1ebb d\u01b0\u1edbi 12 tu\u1ed5i, ng\u01b0\u1eddi b\u1ec7nh gan n\u1eb7ng ho\u1eb7c suy h\u00f4 h\u1ea5p.<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n thi\u1ebfu h\u1ee5t G6PD, ph\u1ee5 n\u1eef cho con b\u00fa, ng\u01b0\u1eddi mang gen chuy\u1ec3n h\u00f3a nhanh qua CYP2D6.<\/p>\n<p>Kh\u00f4ng d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 18 tu\u1ed5i v\u1eeba c\u1eaft amidan ho\u1eb7c n\u1ea1o VA \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng ng\u01b0ng th\u1edf khi ng\u1ee7.<\/p>\n<p>Kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n ti\u00eau ch\u1ea3y c\u1ea5p ho\u1eb7c \u0111ang ho\u1eb7c v\u1eeba s\u1eed d\u1ee5ng thu\u1ed1c \u1ee9c ch\u1ebf MAO trong v\u00f2ng 14 ng\u00e0y.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng cho ng\u01b0\u1eddi suy gan, suy th\u1eadn ho\u1eb7c thi\u1ebfu m\u00e1u. U\u1ed1ng r\u01b0\u1ee3u th\u01b0\u1eddng xuy\u00ean l\u00e0m t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh tr\u00ean gan n\u00ean c\u1ea7n h\u1ea1n ch\u1ebf.<\/p>\n<p>Ng\u01b0\u1eddi m\u1eafc b\u1ec7nh h\u00f4 h\u1ea5p nh\u01b0 hen, kh\u00ed ph\u1ebf th\u0169ng ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed nghi\u1ec7n thu\u1ed1c c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd khi d\u00f9ng codein. Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ec3 gi\u1ea3m ho \u1edf ng\u01b0\u1eddi c\u1ea7n kh\u1ea1c \u0111\u1eddm m\u1ee7.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai, ng\u01b0\u1eddi cho con b\u00fa ho\u1eb7c ng\u01b0\u1eddi ph\u1ea3i l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c n\u00ean tr\u00e1nh d\u00f9ng do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, gi\u1ea3m t\u1eadp trung.<\/p>\n<p>C\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u1ec1 nguy c\u01a1 ph\u00e1t ban n\u1eb7ng nh\u01b0 h\u1ed9i ch\u1ee9ng Stevens-Johnson, Lyell, ho\u1ea1i t\u1eed da nhi\u1ec5m \u0111\u1ed9c hay AGEP.<\/p>\n<p>Codein \u0111\u01b0\u1ee3c gan chuy\u1ec3n h\u00f3a th\u00e0nh morphin th\u00f4ng qua enzym CYP2D6, do \u0111\u00f3 ng\u01b0\u1eddi thi\u1ebfu enzym n\u00e0y c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au. Ng\u01b0\u1ee3c l\u1ea1i, ng\u01b0\u1eddi mang gen chuy\u1ec3n h\u00f3a m\u1ea1nh ho\u1eb7c si\u00eau nhanh c\u00f3 th\u1ec3 b\u1ecb ng\u1ed9 \u0111\u1ed9c morphin ngay \u1edf li\u1ec1u \u0111i\u1ec1u tr\u1ecb, bi\u1ec3u hi\u1ec7n b\u1eb1ng bu\u1ed3n ng\u1ee7, th\u1edf n\u00f4ng, co \u0111\u1ed3ng t\u1eed, n\u00f4n, t\u00e1o b\u00f3n v\u00e0 gi\u1ea3m \u00fd th\u1ee9c. C\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Paracetamol: C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ph\u00e1t ban, m\u00e0y \u0111ay, bu\u1ed3n n\u00f4n, n\u00f4n. Hi\u1ebfm h\u01a1n l\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u ho\u1eb7c \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn khi d\u00f9ng k\u00e9o d\u00e0i. M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p c\u00f3 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng n\u1eb7ng.<\/p>\n<p>Codein:<\/p>\n<ul>\n<li>T\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p l\u00e0 \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, t\u00e1o b\u00f3n, bu\u1ed3n n\u00f4n, b\u00ed ti\u1ec3u, h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf.<\/li>\n<li>\u00cdt g\u1eb7p h\u01a1n l\u00e0 ng\u1ee9a, m\u00e0y \u0111ay, bu\u1ed3n ng\u1ee7, \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p, co th\u1eaft \u0111\u01b0\u1eddng m\u1eadt.<\/li>\n<li>Hi\u1ebfm khi g\u00e2y ph\u1ea3n v\u1ec7, \u1ea3o gi\u00e1c, co gi\u1eadt ho\u1eb7c suy tu\u1ea7n ho\u00e0n.<\/li>\n<li>D\u00f9ng l\u00e2u d\u00e0i v\u1edbi li\u1ec1u cao c\u00f3 th\u1ec3 g\u00e2y l\u1ec7 thu\u1ed9c thu\u1ed1c c\u1ea3 v\u1ec1 th\u1ec3 ch\u1ea5t v\u00e0 t\u00e2m l\u00fd, c\u00e1c tri\u1ec7u ch\u1ee9ng thi\u1ebfu thu\u1ed1c g\u1ed3m run, v\u00e3 m\u1ed3 h\u00f4i, b\u1ed3n ch\u1ed3n, ch\u1ea3y n\u01b0\u1edbc m\u0169i.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Paracetamol:<\/p>\n<ul>\n<li>Metoclopramid v\u00e0 domperidon l\u00e0m t\u0103ng t\u1ed1c \u0111\u1ed9 h\u1ea5p thu; cholestyramin l\u00e0m gi\u1ea3m h\u1ea5p thu.<\/li>\n<li>D\u00f9ng k\u00e9o d\u00e0i c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a warfarin v\u00e0 c\u00e1c coumarin, d\u1eabn \u0111\u1ebfn t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/li>\n<li>Khi ph\u1ed1i h\u1ee3p v\u1edbi isoniazid c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ed9c t\u00ednh tr\u00ean gan.<\/li>\n<\/ul>\n<p>Codein:<\/p>\n<ul>\n<li>C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a metoclopramid v\u00e0 domperidon. L\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh khi d\u00f9ng c\u00f9ng r\u01b0\u1ee3u, thu\u1ed1c ng\u1ee7, thu\u1ed1c an th\u1ea7n, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng ho\u1eb7c phenothiazin.<\/li>\n<li>K\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf MAO c\u00f3 th\u1ec3 g\u00e2y h\u1ed9i ch\u1ee9ng serotonin nguy hi\u1ec3m.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u00f9ng trong thai k\u1ef3 do nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn thai nhi v\u00e0 c\u00f3 th\u1ec3 g\u00e2y suy h\u00f4 h\u1ea5p \u1edf tr\u1ebb s\u01a1 sinh n\u1ebfu d\u00f9ng g\u1ea7n l\u00fac sinh.<\/p>\n<p>Kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef cho con b\u00fa v\u00ec morphin c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 \u1edf n\u1ed3ng \u0111\u1ed9 cao \u1edf ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a nhanh, g\u00e2y ng\u1ed9 \u0111\u1ed9c opioid cho tr\u1ebb b\u00fa m\u1eb9.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, \u0111\u1eb7c bi\u1ec7t khi k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c an th\u1ea7n, do \u0111\u00f3 ng\u01b0\u1eddi d\u00f9ng c\u1ea7n tr\u00e1nh l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh thi\u1ebft b\u1ecb nguy hi\u1ec3m.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Paracetamol:<\/p>\n<ul>\n<li>U\u1ed1ng tr\u00ean 7,5\u20138 g trong 24 gi\u1edd ho\u1eb7c d\u00f9ng li\u1ec1u cao k\u00e9o d\u00e0i c\u00f3 th\u1ec3 g\u00e2y ng\u1ed9 \u0111\u1ed9c.<\/li>\n<li>Tri\u1ec7u ch\u1ee9ng s\u1edbm g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00e1n \u0103n, \u0111au b\u1ee5ng, da t\u00e1i nh\u1ee3t. Sau 12\u201348 gi\u1edd xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u t\u1ed5n th\u01b0\u01a1ng gan, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy gan, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, h\u00f4n m\u00ea gan v\u00e0 t\u1eed vong.<\/li>\n<li>X\u1eed tr\u00ed b\u1eb1ng r\u1eeda d\u1ea1 d\u00e0y c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t, t\u1ed1t nh\u1ea5t trong 4 gi\u1edd \u0111\u1ea7u. \u0110i\u1ec1u tr\u1ecb \u0111\u1eb7c hi\u1ec7u b\u1eb1ng N-acetylcystein ho\u1eb7c methionin n\u1ebfu kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1ea7u tay.<\/li>\n<\/ul>\n<p>Codein:<\/p>\n<ul>\n<li>Ng\u1ed9 \u0111\u1ed9c th\u1ec3 hi\u1ec7n qua \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p, l\u01a1 m\u01a1, h\u00f4n m\u00ea, m\u1ea1ch ch\u1eadm, da l\u1ea1nh, t\u1ee5t huy\u1ebft \u00e1p, c\u00f3 th\u1ec3 ng\u1eebng tim n\u1ebfu n\u1eb7ng.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed7 tr\u1ee3: d\u00f9ng than ho\u1ea1t t\u00ednh, h\u00f4 h\u1ea5p h\u1ed7 tr\u1ee3, cung c\u1ea5p oxy v\u00e0 ti\u00eam naloxon t\u0129nh m\u1ea1ch trong tr\u01b0\u1eddng h\u1ee3p ng\u1ed9 \u0111\u1ed9c n\u1eb7ng.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Thu\u1ed1c Co-Padein 500\/10 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<br \/>\nKh\u00f4ng \u0111\u1ec3 Thu\u1ed1c Co-Padein 500\/10 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Thu\u1ed1c Co-Padein 500\/10 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Co-Padein 500\/10 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Thu\u1ed1c Co-Padein 500\/10 nh\u01b0:<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/zanicidol-500mg-8mg\/\">Zanicidol 500mg\/8mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol v\u00e0 Codein, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m TV.Pharm, ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c c\u01a1n \u0111au c\u00f3 ho\u1eb7c kh\u00f4ng k\u00e8m s\u1ed1t<\/p>\n<p>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/panalganeffer-codein\/\">Panalganeffer codein<\/a> c\u00f3 th\u00e0nh ph\u1ea7n Paracetamol v\u00e0 Codein, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi PHARMEXCO, ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c c\u01a1n \u0111au c\u00f3 ho\u1eb7c kh\u00f4ng k\u00e8m s\u1ed1t<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>GG Graham v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 (2005), Mechanism of action of paracetamol. journals.lww.com. Truy c\u1eadp ng\u00e0y 31 th\u00e1ng 10 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/journals.lww.com\/americantherapeutics\/fulltext\/2005\/01000\/Mechanism_of_Action_of_Paracetamol.8.aspx\" rel=\"noopener\">https:\/\/journals.lww.com\/americantherapeutics\/fulltext\/2005\/01000\/Mechanism_of_Action_of_Paracetamol.8.aspx<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Co-Padein 500\/10 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 gi\u1ea3m \u0111au c\u1ea5p t\u00ednh m\u1ee9c \u0111\u1ed9 trung b\u00ecnh \u1edf ng\u01b0\u1eddi t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean, trong tr\u01b0\u1eddng h\u1ee3p c\u00e1c thu\u1ed1c gi\u1ea3m \u0111au \u0111\u01a1n thu\u1ea7n nh\u01b0 paracetamol ho\u1eb7c ibuprofen kh\u00f4ng c\u00f2n hi\u1ec7u qu\u1ea3.<\/span><\/p>\n","protected":false},"author":1,"featured_media":146713,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-146711","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/146711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=146711"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/146713"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=146711"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=146711"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=146711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}