{"id":146642,"date":"2025-10-30T15:36:35","date_gmt":"2025-10-30T08:36:35","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=146642"},"modified":"2025-10-30T15:41:55","modified_gmt":"2025-10-30T08:41:55","slug":"coperil-4mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/coperil-4mg\/","title":{"rendered":"Coperil 4mg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b><a href=\"https:\/\/vnras.com\/drug\/\"><b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a><b> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Coperil 4mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi <\/b><b>C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang <\/b><b>c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 <\/b><b>VD-22039-14<\/b><\/p>\n<h2>Coperil 4mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Coperil 4mg<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Perindopril erbumin&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;4mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Tinh b\u1ed9t m\u00ec, lactose monohydrat, microcrystalline cellulose M101, crospovidon, povidon K30, magnesi stearat, m\u00e0u indigo carmin lake, m\u00e0u green lake.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-22039-14<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 t\u00fai x 1 v\u1ec9 x 30 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Coperil 4mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Perindopril l\u00e0 m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE), ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n c\u1ea3n qu\u00e1 tr\u00ecnh chuy\u1ec3n angiotensin I th\u00e0nh angiotensin II \u2013 ch\u1ea5t c\u00f3 t\u00e1c d\u1ee5ng co m\u1ea1ch m\u1ea1nh, t\u1eeb \u0111\u00f3 gi\u00fap gi\u00e3n m\u1ea1ch v\u00e0 h\u1ea1 huy\u1ebft \u00e1p. C\u01a1 ch\u1ebf n\u00e0y c\u00f2n l\u00e0m gi\u1ea3m ti\u1ebft aldosteron, g\u00f3p ph\u1ea7n ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p hi\u1ec7u qu\u1ea3 h\u01a1n. \u0110\u1ed3ng th\u1eddi, Perindopril c\u00f2n l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh c\u1ee7a h\u1ec7 kallikrein-kinin v\u00e0 prostaglandin, gi\u00fap t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch, v\u00e0 thu\u1ed1c ph\u00e1t huy hi\u1ec7u l\u1ef1c th\u00f4ng qua ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 perindoprilat.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Sau khi u\u1ed1ng, Perindopril \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 1 gi\u1edd, v\u1edbi sinh kh\u1ea3 d\u1ee5ng dao \u0111\u1ed9ng t\u1eeb 15\u201370%. Kho\u1ea3ng 20% l\u01b0\u1ee3ng thu\u1ed1c h\u1ea5p thu \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh Perindoprilat \u2013 ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong m\u00e1u sau 3\u20134 gi\u1edd. Th\u1ee9c \u0103n c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 chuy\u1ec3n h\u00f3a n\u00e0y, do \u0111\u00f3 thu\u1ed1c \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u00f9ng v\u00e0o bu\u1ed5i s\u00e1ng tr\u01b0\u1edbc khi \u0103n.<\/p>\n<p>Perindoprilat ch\u1ec9 li\u00ean k\u1ebft y\u1ebfu v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (&lt;30%) v\u00e0 \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ph\u1ea7n t\u1ef1 do kho\u1ea3ng 3\u20135 gi\u1edd, tuy nhi\u00ean do li\u00ean k\u1ebft v\u1edbi men ACE n\u00ean th\u1eddi gian b\u00e1n th\u1ea3i hi\u1ec7u qu\u1ea3 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u0111\u1ebfn 25 gi\u1edd.<\/p>\n<p>Thu\u1ed1c \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau kho\u1ea3ng 4 ng\u00e0y s\u1eed d\u1ee5ng li\u00ean t\u1ee5c. \u1ede ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n suy th\u1eadn ho\u1eb7c suy tim, qu\u00e1 tr\u00ecnh th\u1ea3i tr\u1eeb thu\u1ed1c b\u1ecb ch\u1eadm l\u1ea1i n\u00ean c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u ph\u00f9 h\u1ee3p.<\/p>\n<h2>Thu\u1ed1c Coperil 4mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p \u2013 c\u00f3 th\u1ec3 d\u00f9ng \u0111\u01a1n tr\u1ecb ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c h\u1ea1 \u00e1p kh\u00e1c.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>B\u1ec7nh m\u1ea1ch v\u00e0nh \u1ed5n \u0111\u1ecbnh \u2013 gi\u00fap gi\u1ea3m nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5 ho\u1eb7c t\u1eed vong do tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><em><strong>T\u0103ng huy\u1ebft \u00e1p<\/strong><\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 1 vi\u00ean (4 mg) u\u1ed1ng 1 l\u1ea7n\/ng\u00e0y v\u00e0o bu\u1ed5i s\u00e1ng.<\/p>\n<p>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u: Sau 1 th\u00e1ng, n\u1ebfu dung n\u1ea1p t\u1ed1t, c\u00f3 th\u1ec3 t\u0103ng l\u00ean 2 vi\u00ean (8 mg) m\u1ed7i ng\u00e0y.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p (m\u1ea5t mu\u1ed1i, suy tim m\u1ea5t b\u00f9, t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng): b\u1eaft \u0111\u1ea7u v\u1edbi \u00bd vi\u00ean (2 mg)\/ng\u00e0y, \u0111i\u1ec1u tr\u1ecb d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u1ee7a b\u00e1c s\u0129.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: kh\u1edfi \u0111\u1ea7u \u00bd vi\u00ean (2 mg)\/ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng d\u1ea7n l\u00ean 1 vi\u00ean (4 mg) r\u1ed3i 2 vi\u00ean (8 mg) t\u00f9y \u0111\u00e1p \u1ee9ng v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p><em><strong>Suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng<\/strong><\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: \u00bd vi\u00ean (2 mg) u\u1ed1ng 1 l\u1ea7n m\u1ed7i s\u00e1ng.<\/p>\n<p>T\u0103ng li\u1ec1u: c\u00f3 th\u1ec3 t\u0103ng l\u00ean 1 vi\u00ean (4 mg)\/ng\u00e0y sau m\u1ed7i 2 tu\u1ea7n, t\u00f9y \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p.<\/p>\n<p><em><strong>B\u1ec7nh m\u1ea1ch v\u00e0nh \u1ed5n \u0111\u1ecbnh<\/strong><\/em><\/p>\n<p>2 tu\u1ea7n \u0111\u1ea7u: d\u00f9ng 1 vi\u00ean (4 mg)\/ng\u00e0y.<\/p>\n<p>Sau 2 tu\u1ea7n: n\u1ebfu dung n\u1ea1p t\u1ed1t, t\u0103ng l\u00ean 2 vi\u00ean (8 mg)\/ng\u00e0y.<\/p>\n<p><em><strong>Ng\u01b0\u1eddi cao tu\u1ed5i<\/strong><\/em><\/p>\n<p>Tu\u1ea7n 1: \u00bd vi\u00ean (2 mg)\/ng\u00e0y.<\/p>\n<p>Tu\u1ea7n 2: 1 vi\u00ean (4 mg)\/ng\u00e0y.<\/p>\n<p>Sau \u0111\u00f3, c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ebfn 2 vi\u00ean (8 mg)\/ng\u00e0y n\u1ebfu \u0111\u00e1p \u1ee9ng t\u1ed1t.<\/p>\n<p>Suy th\u1eadn \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo khuy\u1ebfn c\u00e1o b\u00e1c s\u0129 ho\u1eb7c nh\u00e0 sane xu\u1ea5t<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>U\u1ed1ng nguy\u00ean <strong>vi\u00ean n\u00e9n Coperil 4mg<\/strong> v\u1edbi n\u01b0\u1edbc, t\u1ed1t nh\u1ea5t v\u00e0o bu\u1ed5i s\u00e1ng tr\u01b0\u1edbc b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Coperil 4mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng ho\u1eb7c qu\u00e1 m\u1eabn v\u1edbi Perindopril, b\u1ea5t k\u1ef3 thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE) n\u00e0o kh\u00e1c ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c (nh\u01b0 tinh b\u1ed9t m\u00ec, lactose).<\/p>\n<p>B\u1ec7nh nh\u00e2n t\u1eebng b\u1ecb ph\u00f9 m\u1ea1ch (ph\u00f9 m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i, h\u1ecdng ho\u1eb7c thanh qu\u1ea3n) khi d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ph\u00f9 m\u1ea1ch di truy\u1ec1n ho\u1eb7c v\u00f4 c\u0103n.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai \u1edf 3 th\u00e1ng gi\u1eefa v\u00e0 3 th\u00e1ng cu\u1ed1i thai k\u1ef3.<\/p>\n<p>Kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ee9a aliskiren \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn (GFR &lt; 60 ml\/ph\u00fat\/1,73 m\u00b2).<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng c\u00f9ng ho\u1eb7c trong v\u00f2ng 36 gi\u1edd sau khi d\u00f9ng sacubitril\/valsartan, do nguy c\u01a1 cao g\u00e2y ph\u00f9 m\u1ea1ch nghi\u00eam tr\u1ecdng.<\/p>\n<figure id=\"attachment_146643\" aria-describedby=\"caption-attachment-146643\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-146643\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4.jpg\" alt=\"Coperil 4mg\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Coperil-4-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-146643\" class=\"wp-caption-text\">Thu\u1ed1c Coperil 4mg c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p, suy tim<\/figcaption><\/figure>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>H\u1ea1 huy\u1ebft \u00e1p c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n m\u1ea5t mu\u1ed1i, m\u1ea5t n\u01b0\u1edbc ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u n\u00ean c\u1ea7n theo d\u00f5i khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Suy th\u1eadn \u0111\u00f2i h\u1ecfi \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo \u0111\u1ed9 thanh th\u1ea3i creatinin v\u00e0 theo d\u00f5i \u0111\u1ecbnh k\u1ef3 n\u1ed3ng \u0111\u1ed9 creatinin c\u00f9ng kali huy\u1ebft.<\/p>\n<p>Suy gan c\u1ea7n th\u1eadn tr\u1ecdng, n\u1ebfu xu\u1ea5t hi\u1ec7n v\u00e0ng da ho\u1eb7c t\u0103ng men gan ph\u1ea3i ng\u1eebng thu\u1ed1c.<\/p>\n<p>Ph\u00f9 m\u1ea1ch c\u00f3 th\u1ec3 x\u1ea3y ra v\u1edbi bi\u1ec3u hi\u1ec7n s\u01b0ng m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i ho\u1eb7c kh\u00f3 th\u1edf v\u00e0 c\u1ea7n ng\u1eebng thu\u1ed1c ngay.<\/p>\n<p>Tr\u00e1nh ph\u1ed1i h\u1ee3p thu\u1ed1c v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, ch\u1ebf ph\u1ea9m b\u1ed5 sung kali ho\u1eb7c mu\u1ed1i thay th\u1ebf ch\u1ee9a kali \u0111\u1ec3 ph\u00f2ng ng\u1eeba t\u0103ng kali huy\u1ebft.<\/p>\n<p>Ho khan l\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 g\u1eb7p do \u1ee9c ch\u1ebf men chuy\u1ec3n v\u00e0 c\u1ea7n ng\u01b0ng thu\u1ed1c n\u1ebfu ho k\u00e9o d\u00e0i.<\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p ph\u1eabu thu\u1eadt ho\u1eb7c g\u00e2y m\u00ea l\u1edbn n\u00ean t\u1ea1m ng\u1eebng thu\u1ed1c \u00edt nh\u1ea5t m\u1ed9t ng\u00e0y tr\u01b0\u1edbc.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng s\u1eed d\u1ee5ng v\u00e0 ph\u1ea3i d\u1eebng thu\u1ed1c ngay khi ph\u00e1t hi\u1ec7n c\u00f3 thai.<\/p>\n<p>Thu\u1ed1c ch\u1ee9a lactose v\u00e0 tinh b\u1ed9t m\u00ec n\u00ean kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi kh\u00f4ng dung n\u1ea1p galactose ho\u1eb7c d\u1ecb \u1ee9ng v\u1edbi l\u00faa m\u00ec.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: ho khan, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u, m\u1ec7t m\u1ecfi, bu\u1ed3n n\u00f4n, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, ph\u00e1t ban ho\u1eb7c ng\u1ee9a.<\/p>\n<p>\u00cdt g\u1eb7p: h\u1ea1 huy\u1ebft \u00e1p, kh\u00f4 mi\u1ec7ng, suy th\u1eadn, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng, gi\u1ea3m ham mu\u1ed1n t\u00ecnh d\u1ee5c ho\u1eb7c b\u1ea5t l\u1ef1c.<\/p>\n<p>Hi\u1ebfm v\u00e0 r\u1ea5t hi\u1ebfm g\u1eb7p: ph\u00f9 m\u1ea1ch v\u00f9ng m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i ho\u1eb7c h\u1ecdng; gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, vi\u00eam gan, vi\u00eam t\u1ee5y, lo\u1ea1n nh\u1ecbp tim, \u0111\u1ed9t qu\u1ef5 ho\u1eb7c vi\u00eam ph\u1ed5i t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan. Ngo\u00e0i ra, c\u00f3 th\u1ec3 ghi nh\u1eadn t\u0103ng nh\u1eb9 n\u1ed3ng \u0111\u1ed9 creatinin, ure ho\u1eb7c kali trong m\u00e1u \u2013 c\u00e1c ch\u1ec9 s\u1ed1 n\u00e0y th\u01b0\u1eddng tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng sau khi ng\u1eebng thu\u1ed1c.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u: C\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p m\u1ea1nh khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi gi\u1ea3m th\u1ec3 t\u00edch ho\u1eb7c m\u1ea5t mu\u1ed1i.<\/p>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, b\u1ed5 sung kali, mu\u1ed1i thay th\u1ebf ch\u1ee9a kali: T\u0103ng nguy c\u01a1 t\u0103ng kali huy\u1ebft, c\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 kali th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p>Cyclosporin, heparin: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng kali huy\u1ebft, n\u00ean gi\u00e1m s\u00e1t s\u00e1t sao khi d\u00f9ng chung.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID), bao g\u1ed3m aspirin li\u1ec1u cao: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p, \u0111\u1ed3ng th\u1eddi t\u0103ng nguy c\u01a1 suy th\u1eadn v\u00e0 t\u0103ng kali huy\u1ebft.<\/p>\n<p>Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c, nitrat ho\u1eb7c thu\u1ed1c gi\u00e3n m\u1ea1ch: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n<p>Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, \u0111\u1eb7c bi\u1ec7t trong giai \u0111o\u1ea1n \u0111\u1ea7u khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Sacubitril\/valsartan, thu\u1ed1c \u1ee9c ch\u1ebf mTOR, vildagliptin: L\u00e0m t\u0103ng nguy c\u01a1 ph\u00f9 m\u1ea1ch, n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng ho\u1eb7c thu\u1ed1c m\u00ea: C\u00f3 th\u1ec3 l\u00e0m h\u1ea1 huy\u1ebft \u00e1p m\u1ea1nh h\u01a1n.<\/p>\n<p>Thu\u1ed1c k\u00edch th\u00edch th\u1ea7n kinh giao c\u1ea3m: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p c\u1ee7a perindopril.<\/p>\n<p>Thu\u1ed1c kh\u00e1ng acid: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu perindopril, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Perindopril trong 3 th\u00e1ng \u0111\u1ea7u thai k\u1ef3 v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong qu\u00fd 2 v\u00e0 qu\u00fd 3 do nguy c\u01a1 g\u00e2y \u0111\u1ed9c cho thai nh\u01b0 suy th\u1eadn, thi\u1ec3u \u1ed1i v\u00e0 ch\u1eadm ph\u00e1t tri\u1ec3n x\u01b0\u01a1ng s\u1ecd. N\u1ebfu \u0111ang \u0111i\u1ec1u tr\u1ecb m\u00e0 ph\u00e1t hi\u1ec7n c\u00f3 thai, c\u1ea7n ng\u1eebng thu\u1ed1c ngay v\u00e0 thay th\u1ebf b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb an to\u00e0n h\u01a1n. Tr\u01b0\u1eddng h\u1ee3p thai ph\u1ee5 \u0111\u00e3 d\u00f9ng thu\u1ed1c \u1edf giai \u0111o\u1ea1n mu\u1ed9n c\u1ee7a thai k\u1ef3, c\u1ea7n si\u00eau \u00e2m ki\u1ec3m tra ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n h\u1ed9p s\u1ecd c\u1ee7a thai, \u0111\u1ed3ng th\u1eddi theo d\u00f5i huy\u1ebft \u00e1p c\u1ee7a tr\u1ebb s\u01a1 sinh sau khi ch\u00e0o \u0111\u1eddi<\/p>\n<p>\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef cho con b\u00fa, hi\u1ec7n ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 t\u00ednh an to\u00e0n c\u1ee7a Perindopril, v\u00ec v\u1eady kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng, \u0111\u1eb7c bi\u1ec7t \u1edf tr\u1ebb s\u01a1 sinh ho\u1eb7c tr\u1ebb sinh non.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a Perindopril \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Tuy nhi\u00ean, do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t ho\u1eb7c m\u1ec7t m\u1ecfi \u2013 \u0111\u1eb7c bi\u1ec7t trong giai \u0111o\u1ea1n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c khi huy\u1ebft \u00e1p h\u1ea1 qu\u00e1 m\u1ee9c \u2013 n\u00ean ng\u01b0\u1eddi d\u00f9ng c\u1ea7n th\u1eadn tr\u1ecdng khi tham gia c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 t\u1eadp trung cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng khi qu\u00e1 li\u1ec1u Perindopril c\u00f3 th\u1ec3 bao g\u1ed3m h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng, s\u1ed1c tu\u1ea7n ho\u00e0n, r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i, suy th\u1eadn, nh\u1ecbp tim nhanh ho\u1eb7c ch\u1eadm, ch\u00f3ng m\u1eb7t v\u00e0 ho.<\/p>\n<p>X\u1eed tr\u00ed n\u00ean bao g\u1ed3m truy\u1ec1n t\u0129nh m\u1ea1ch dung d\u1ecbch NaCl 0,9% v\u00e0 \u0111\u1eb7t b\u1ec7nh nh\u00e2n n\u1eb1m ng\u1eeda, \u0111\u1ea7u th\u1ea5p \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh huy\u1ebft \u00e1p; n\u1ebfu c\u1ea7n, c\u00f3 th\u1ec3 d\u00f9ng angiotensin II ho\u1eb7c catecholamin ti\u00eam t\u0129nh m\u1ea1ch.<\/p>\n<p>Perindopril c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u, v\u00e0 v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p nh\u1ecbp tim ch\u1eadm dai d\u1eb3ng, c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc \u0111\u1eb7t m\u00e1y t\u1ea1o nh\u1ecbp t\u1ea1m th\u1eddi. Trong qu\u00e1 tr\u00ecnh n\u00e0y, c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c ch\u1ec9 s\u1ed1 sinh t\u1ed3n, \u0111i\u1ec7n gi\u1ea3i v\u00e0 creatinin m\u00e1u.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Coperil 4mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Coperil 4mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Coperil 4mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p><span style=\"font-size: 14.4px;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Coperil 4mg nh\u01b0:<\/span><\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/cosaten-4\/\">Cosaten 4<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Perindopril 4mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C DANAPHA, \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 tim m\u1ea1ch nh\u01b0 cao huy\u1ebft \u00e1p v\u00e0 suy tim sung huy\u1ebft<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/perindastad-4\/\">Perindastad 4<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Perindopril 4mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH LD Stellapharm, \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 tim m\u1ea1ch nh\u01b0 cao huy\u1ebft \u00e1p v\u00e0 suy tim sung huy\u1ebft<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Coperil 4mg \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/To-huong-dan-su-dung-Coperil-4mg-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 30 th\u00e1ng 10 n\u0103m 2025<\/li>\n<li>Ghiadoni L (2011). Perindopril for the treatment of hypertension. Expert Opin Pharmacother. Truy c\u1eadp ng\u00e0y 30 th\u00e1ng 10 n\u0103m 2025 t\u1eeb: <a style=\"font-size: 14.4px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21599567\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21599567\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Coperil 4mg gi\u00fap ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p, \u0111i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng v\u00e0 gi\u1ea3m nguy c\u01a1 t\u00e1i ph\u00e1t bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim ho\u1eb7c can thi\u1ec7p m\u1ea1ch v\u00e0nh.<\/p>\n","protected":false},"author":1,"featured_media":146644,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-146642","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/146642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=146642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/146644"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=146642"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=146642"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=146642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}