{"id":144589,"date":"2025-10-13T16:38:30","date_gmt":"2025-10-13T09:38:30","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=144589"},"modified":"2025-10-13T16:39:52","modified_gmt":"2025-10-13T09:39:52","slug":"pradaxa-150mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/pradaxa-150mg\/","title":{"rendered":"Pradaxa 150mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Pradaxa 150mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH &amp; Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-17270-13.<\/strong><\/p>\n<h2>Pradaxa 150mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Ho\u1ea1t ch\u1ea5t ch\u00ednh trong<strong> Pradaxa 150mg<\/strong> l\u00e0 : M\u1ed7i vi\u00ean nang c\u1ee9ng ch\u1ee9a <strong>Dabigatran <\/strong>etexilate mesylate t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 150mg Dabigatran etexilate.<\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Acacia, tartaric acid, hypromellose, dimethicone, talc, hydroxypropyl cellulose, v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c c\u1ee7a v\u1ecf nang.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-17270-13<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u1ee9ng<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Germany<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Pradaxa 150mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Dabigatran etexilate sau khi u\u1ed1ng s\u1ebd chuy\u1ec3n h\u00f3a th\u00e0nh dabigatran. Dabigatran \u1ee9c ch\u1ebf tr\u1ef1c ti\u1ebfp enzym thrombin, ng\u0103n ch\u1eb7n s\u1ef1 h\u00ecnh th\u00e0nh fibrin (s\u1ee3i huy\u1ebft), l\u00e0 b\u01b0\u1edbc cu\u1ed1i c\u00f9ng trong vi\u1ec7c t\u1ea1o ra c\u1ee5c m\u00e1u \u0111\u00f4ng. Nh\u1edd \u0111\u00f3, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng m\u00e1u m\u1ea1nh m\u1ebd.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Sau khi u\u1ed1ng, dabigatran etexilate \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0 chuy\u1ec3n h\u00f3a th\u00e0nh dabigatran, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong m\u00e1u sau 0.5 &#8211; 2 gi\u1edd. Thu\u1ed1c \u00edt li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (~35%) v\u00e0 ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua th\u1eadn. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c l\u00e0 12-17 gi\u1edd \u1edf ng\u01b0\u1eddi c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng v\u00e0 s\u1ebd k\u00e9o d\u00e0i h\u01a1n \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<h2>Thu\u1ed1c Pradaxa 150mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc h\u1ec7 th\u1ed1ng: \u1ede b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh b\u1ecb rung nh\u0129 kh\u00f4ng do b\u1ec7nh van tim (NVAF) c\u00f3 m\u1ed9t ho\u1eb7c nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 nh\u01b0: \u0111\u00e3 t\u1eebng b\u1ecb \u0111\u1ed9t qu\u1ef5 ho\u1eb7c c\u01a1n thi\u1ebfu m\u00e1u n\u00e3o tho\u00e1ng qua (TIA), tu\u1ed5i \u2265 75, suy tim (ph\u00e2n lo\u1ea1i NYHA \u0111\u1ed9 II tr\u1edf l\u00ean), \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u (DVT) v\u00e0\/ho\u1eb7c thuy\u00ean t\u1eafc ph\u1ed5i (PE): V\u00e0 ph\u00f2ng ng\u1eeba t\u1eed vong li\u00ean quan.<\/p>\n<p>Ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u (DVT) v\u00e0\/ho\u1eb7c thuy\u00ean t\u1eafc ph\u1ed5i (PE): V\u00e0 t\u1eed vong li\u00ean quan.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h2>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>Ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129 (NVAF): Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 1 vi\u00ean 150mg, u\u1ed1ng 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb v\u00e0 ph\u00f2ng ng\u1eeba DVT\/PE: Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 1 vi\u00ean 150mg, u\u1ed1ng 2 l\u1ea7n m\u1ed7i ng\u00e0y, sau khi \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng ti\u00eam trong \u00edt nh\u1ea5t 5 ng\u00e0y.<\/p>\n<p>L\u01b0u \u00fd: Li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh b\u1edfi b\u00e1c s\u0129 \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t nh\u01b0 ng\u01b0\u1eddi cao tu\u1ed5i (tr\u00ean 80 tu\u1ed5i), b\u1ec7nh nh\u00e2n suy th\u1eadn trung b\u00ecnh, ho\u1eb7c b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u cao.<\/p>\n<h3>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>U\u1ed1ng nguy\u00ean vi\u00ean nang v\u1edbi m\u1ed9t c\u1ed1c n\u01b0\u1edbc \u0111\u1ea7y, c\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n. Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng m\u1edf, nhai hay nghi\u1ec1n vi\u00ean nang v\u00ec s\u1ebd l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Pradaxa 150mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi dabigatran etexilate ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinin CrCL &lt; 30 mL\/ph\u00fat).<\/p>\n<p>\u0110ang c\u00f3 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p>T\u1ed5n th\u01b0\u01a1ng ho\u1eb7c t\u00ecnh tr\u1ea1ng c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u n\u1eb7ng (v\u00ed d\u1ee5: lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng, kh\u1ed1i u \u00e1c t\u00ednh c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u cao, t\u1ed5n th\u01b0\u01a1ng n\u00e3o ho\u1eb7c c\u1ed9t s\u1ed1ng g\u1ea7n \u0111\u00e2y, xu\u1ea5t huy\u1ebft n\u1ed9i s\u1ecd g\u1ea7n \u0111\u00e2y).<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111\u1eb7t van tim nh\u00e2n t\u1ea1o c\u01a1 h\u1ecdc.<\/p>\n<p>Suy gan ho\u1eb7c b\u1ec7nh gan c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00ednh m\u1ea1ng.<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh P-glycoprotein nh\u01b0 ketoconazole to\u00e0n th\u00e2n, cyclosporin, itraconazole v\u00e0 dronedarone.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Vi\u1ec7c d\u1eebng thu\u1ed1c Pradaxa m\u00e0 kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i, \u0111\u1ed9t qu\u1ef5 ho\u1eb7c c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch kh\u00e1c. N\u1ebfu c\u1ea7n ng\u01b0ng thu\u1ed1c \u0111\u1ec3 ph\u1eabu thu\u1eadt, b\u00e1c s\u0129 s\u1ebd c\u00f3 k\u1ebf ho\u1ea1ch c\u1ee5 th\u1ec3.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn ch\u1ea3y m\u00e1u l\u00e0 ph\u1ed5 bi\u1ebfn nh\u1ea5t, t\u1eeb ch\u1ea3y m\u00e1u nh\u1eb9 (ch\u1ea3y m\u00e1u cam, b\u1ea7m t\u00edm) \u0111\u1ebfn ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng (xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, xu\u1ea5t huy\u1ebft n\u1ed9i s\u1ecd). C\u00e1c r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u01b0 kh\u00f3 ti\u00eau, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n c\u0169ng th\u01b0\u1eddng g\u1eb7p.<\/p>\n<p>\u00cdt g\u1eb7p: Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, t\u0103ng men gan.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Pradaxa c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u (NSAIDs, aspirin, clopidogrel) v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c c\u1ea3m \u1ee9ng P-glycoprotein (v\u00ed d\u1ee5: verapamil, amiodarone, rifampicin).<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Tr\u00e1nh s\u1eed d\u1ee5ng Pradaxa tr\u1eeb khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u Pradaxa l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u. Hi\u1ec7n nay, \u0111\u00e3 c\u00f3 ch\u1ea5t gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u l\u00e0 Idarucizumab (t\u00ean th\u01b0\u01a1ng m\u1ea1i: Praxbind), m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft nhanh ch\u00f3ng v\u00e0 \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a dabigatran trong c\u00e1c t\u00ecnh hu\u1ed1ng kh\u1ea9n c\u1ea5p nh\u01b0 ch\u1ea3y m\u00e1u \u0111e d\u1ecda t\u00ednh m\u1ea1ng ho\u1eb7c c\u1ea7n ph\u1eabu thu\u1eadt c\u1ea5p c\u1ee9u.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c trong bao b\u00ec g\u1ed1c \u0111\u1ec3 tr\u00e1nh \u1ea9m.<\/p>\n<p>B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30\u00b0C.<\/p>\n<p>\u0110\u1ed1i v\u1edbi d\u1ea1ng chai, sau khi m\u1edf n\u1eafp, thu\u1ed1c ch\u1ec9 n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong v\u00f2ng 4 th\u00e1ng.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Pradaxa 150mg<\/h2>\n<p>Ngo\u00e0i Pradaxa 150mg, c\u00f2n c\u00f3 <a href=\"https:\/\/vnras.com\/drug\/pradaxa-110mg\/\">Pradaxa 110mg <\/a>(S\u0110K: VN-16443-13) , \u0111\u00e2y l\u00e0 li\u1ec1u d\u00f9ng thay th\u1ebf d\u00e0nh cho c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u cao, ng\u01b0\u1eddi tr\u00ean 80 tu\u1ed5i, ho\u1eb7c ng\u01b0\u1eddi \u0111ang d\u00f9ng \u0111\u1ed3ng th\u1eddi verapamil. B\u00e1c s\u0129 s\u1ebd l\u00e0 ng\u01b0\u1eddi quy\u1ebft \u0111\u1ecbnh li\u1ec1u d\u00f9ng ph\u00f9 h\u1ee3p nh\u1ea5t sau khi c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 cho t\u1eebng b\u1ec7nh nh\u00e2n c\u1ee5 th\u1ec3.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>Michele Wood, Paul Shaw. Pradaxa-induced esophageal ulcer, truy c\u1eadp ng\u00e0y 13 th\u00e1ng 10 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26452739\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26452739\/<\/a><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Pradaxa 150mg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i file<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Huong-dan-su-dung-thuoc-Pradaxa-150mg.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Pradaxa 150mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH &amp; Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-17270-13, ng\u0103n ng\u1eeba s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c c\u1ee5c m\u00e1u \u0111\u00f4ng.<\/p>\n","protected":false},"author":1,"featured_media":144592,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-144589","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/144589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=144589"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/144592"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=144589"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=144589"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=144589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}