{"id":143871,"date":"2025-10-08T14:42:18","date_gmt":"2025-10-08T07:42:18","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=143871"},"modified":"2025-10-08T14:49:29","modified_gmt":"2025-10-08T07:49:29","slug":"celofen-100","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/celofen-100\/","title":{"rendered":"Celofen 100"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Celofen 100 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Hetero Labs Limited c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 890110525224 (S\u0110K c\u0169: VN-20176-16)<\/strong><\/p>\n<h2>Celofen 100 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Celofen 100<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Celecoxib&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..100mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Lactose monohydrat, croscarmellose natri, povidon, natri lauryl sulfat, magnesi stearat v\u00e0 v\u1ecf nang gelatin c\u1ee9ng.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u1ee9ng<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 890110525224 (S\u0110K c\u0169: VN-20176-16)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 24 th\u00e1ng<\/p>\n<p>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Celofen 100<\/p>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Celecoxib l\u00e0 thu\u1ed1c thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc cyclooxygenase-2 (COX-2). B\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzym n\u00e0y, thu\u1ed1c l\u00e0m gi\u1ea3m t\u1ed5ng h\u1ee3p prostaglandin \u2013 nh\u1eefng ch\u1ea5t \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c g\u00e2y ra ph\u1ea3n \u1ee9ng vi\u00eam, \u0111au v\u00e0 s\u1ed1t.<\/p>\n<p>\u1ede li\u1ec1u \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng (200\u2013400 mg\/ng\u00e0y), celecoxib h\u1ea7u nh\u01b0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn COX-1 \u2013 enzym ch\u1ecbu tr\u00e1ch nhi\u1ec7m b\u1ea3o v\u1ec7 ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y v\u00e0 duy tr\u00ec ch\u1ee9c n\u0103ng th\u1eadn. Ch\u00ednh nh\u1edd t\u00ednh ch\u1ecdn l\u1ecdc n\u00e0y, thu\u1ed1c mang l\u1ea1i hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam t\u1ed1t m\u00e0 v\u1eabn h\u1ea1n ch\u1ebf \u0111\u01b0\u1ee3c nguy c\u01a1 lo\u00e9t ho\u1eb7c xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u2013 t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p \u1edf c\u00e1c thu\u1ed1c NSAID th\u1ebf h\u1ec7 c\u0169.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Sau khi u\u1ed1ng, celecoxib \u0111\u01b0\u1ee3c h\u1ea5p thu kh\u00e1 nhanh, v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng v\u00e0i ba gi\u1edd. Khi d\u00f9ng c\u00f9ng b\u1eefa \u0103n gi\u00e0u ch\u1ea5t b\u00e9o, th\u1eddi gian \u0111\u1ea1t \u0111\u1ec9nh c\u00f3 th\u1ec3 k\u00e9o d\u00e0i l\u00ean kho\u1ea3ng 4 gi\u1edd v\u00e0 sinh kh\u1ea3 d\u1ee5ng t\u0103ng th\u00eam kho\u1ea3ng 20%. D\u1ea1ng thu\u1ed1c r\u1eafc l\u00ean th\u1ee9c \u0103n m\u1ec1m (nh\u01b0 s\u1ed1t t\u00e1o) cho kh\u1ea3 n\u0103ng h\u1ea5p thu t\u01b0\u01a1ng t\u1ef1 nh\u01b0 khi d\u00f9ng vi\u00ean nang nguy\u00ean v\u1eb9n.<\/p>\n<p>Ph\u00e2n b\u1ed1: Trong huy\u1ebft t\u01b0\u01a1ng, kho\u1ea3ng 97% l\u01b0\u1ee3ng celecoxib g\u1eafn v\u1edbi protein, ch\u1ee7 y\u1ebfu l\u00e0 albumin. Thu\u1ed1c kh\u00f4ng ph\u00e2n b\u1ed1 \u0111\u00e1ng k\u1ec3 v\u00e0o h\u1ed3ng c\u1ea7u.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Celecoxib \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n \u1edf gan nh\u1edd enzym CYP2C9 c\u1ee7a h\u1ec7 cytochrom P450. Qu\u00e1 tr\u00ecnh n\u00e0y t\u1ea1o ra c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f2n ho\u1ea1t t\u00ednh, bao g\u1ed3m r\u01b0\u1ee3u b\u1eadc m\u1ed9t, acid carboxylic v\u00e0 c\u00e1c d\u1ea1ng li\u00ean h\u1ee3p glucuronid. \u1ede ng\u01b0\u1eddi mang ki\u1ec3u gen CYP2C9*3, qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u00f3 th\u1ec3 di\u1ec5n ra ch\u1eadm h\u01a1n, d\u1eabn \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u cao h\u01a1n b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Sau khi chuy\u1ec3n h\u00f3a, h\u1ea1ot ch\u1ea5t c\u1ee7a Celofen 100 \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i ch\u1ee7 y\u1ebfu qua ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u, v\u1edbi ch\u01b0a \u0111\u1ebfn 1% \u0111\u01b0\u1ee3c th\u1ea3i ra d\u01b0\u1edbi d\u1ea1ng nguy\u00ean v\u1eb9n. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a celecoxib th\u01b0\u1eddng n\u1eb1m trong kho\u1ea3ng t\u1eeb 8 \u0111\u1ebfn 12 gi\u1edd, v\u00e0 n\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh trong huy\u1ebft t\u01b0\u01a1ng th\u01b0\u1eddng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 5 ng\u00e0y d\u00f9ng thu\u1ed1c li\u00ean t\u1ee5c.<\/p>\n<h2>Thu\u1ed1c Celofen 100 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Gi\u1ea3m \u0111au v\u00e0 vi\u00eam trong tho\u00e1i h\u00f3a kh\u1edbp (OA).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (RA).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp t\u1ef1 ph\u00e1t thi\u1ebfu ni\u00ean (JRA) \u1edf tr\u1ebb t\u1eeb 2 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p>Gi\u1ea3m \u0111au v\u00e0 vi\u00eam trong vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp (AS).<\/p>\n<p>Gi\u1ea3m \u0111au c\u1ea5p t\u00ednh \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb \u0111au b\u1ee5ng kinh nguy\u00ean ph\u00e1t.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><em><strong>Tho\u00e1i h\u00f3a kh\u1edbp<\/strong><\/em>: U\u1ed1ng t\u1ed5ng li\u1ec1u 200mg m\u1ed7i ng\u00e0y, c\u00f3 th\u1ec3 d\u00f9ng 2 vi\u00ean m\u1ed9t l\u1ea7n duy nh\u1ea5t trong ng\u00e0y ho\u1eb7c 1 vi\u00ean hai l\u1ea7n trong ng\u00e0y, t\u00f9y theo \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n<p><em><strong>Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/strong><\/em>: Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u01b0\u1eddng l\u00e0 1\u20132 vi\u00ean\/l\u1ea7n, d\u00f9ng hai l\u1ea7n trong ng\u00e0y, \u0111i\u1ec1u ch\u1ec9nh theo m\u1ee9c \u0111\u1ed9 vi\u00eam v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p><em><strong>Vi\u00eam kh\u1edbp t\u1ef1 ph\u00e1t thi\u1ebfu ni\u00ean<\/strong><\/em><\/p>\n<p>Tr\u1ebb c\u00f3 c\u00e2n n\u1eb7ng t\u1eeb tr\u00ean 10 kg \u0111\u1ebfn d\u01b0\u1edbi 25 kg: U\u1ed1ng n\u1eeda vi\u00ean (t\u01b0\u01a1ng \u1ee9ng 50mg) hai l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n<p>Tr\u1ebb tr\u00ean 25 kg: D\u00f9ng 1 vi\u00ean hai l\u1ea7n\/ng\u00e0y.<\/p>\n<p><em><strong>Vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp<\/strong><\/em>: Li\u1ec1u th\u00f4ng th\u01b0\u1eddng 200mg\/ng\u00e0y (t\u1ee9c 2 vi\u00ean, c\u00f3 th\u1ec3 u\u1ed1ng m\u1ed9t l\u1ea7n ho\u1eb7c chia l\u00e0m hai l\u1ea7n). N\u1ebfu sau kho\u1ea3ng 6 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb m\u00e0 ch\u01b0a \u0111\u1ea1t hi\u1ec7u qu\u1ea3 mong mu\u1ed1n, c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ebfn 400mg\/ng\u00e0y (4 vi\u00ean); trong tr\u01b0\u1eddng h\u1ee3p v\u1eabn kh\u00f4ng c\u1ea3i thi\u1ec7n, n\u00ean c\u00e2n nh\u1eafc \u0111\u1ed5i sang ph\u00e1c \u0111\u1ed3 kh\u00e1c.<\/p>\n<p><em><strong>\u0110au c\u1ea5p t\u00ednh ho\u1eb7c \u0111au do nguy\u00ean nh\u00e2n b\u1ee5ng kinh nguy\u00ean ph\u00e1t<\/strong><\/em><\/p>\n<p>Ng\u00e0y \u0111\u1ea7u ti\u00ean: U\u1ed1ng 4 vi\u00ean (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 400mg), khi c\u1ea7n thi\u1ebft c\u00f3 th\u1ec3 b\u1ed5 sung th\u00eam 2 vi\u00ean (200mg).<\/p>\n<p>C\u00e1c ng\u00e0y k\u1ebf ti\u1ebfp: Duy tr\u00ec v\u1edbi li\u1ec1u 2 vi\u00ean Celofen 100 m\u1ed7i l\u1ea7n, ng\u00e0y d\u00f9ng hai l\u1ea7n.<\/p>\n<p><em><strong>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/strong><\/em><\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan m\u1ee9c \u0111\u1ed9 trung b\u00ecnh (Child-Pugh B): C\u1ea7n gi\u1ea3m 50% so v\u1edbi li\u1ec1u th\u00f4ng th\u01b0\u1eddng.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng: Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c \u1edf nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ki\u1ec3u gen chuy\u1ec3n h\u00f3a k\u00e9m qua CYP2C9: N\u00ean kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t n\u1eeda li\u1ec1u th\u1ea5p nh\u1ea5t \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p><strong>Vi\u00ean nang Celofen 100<\/strong> c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi kh\u00f3 nu\u1ed1t, c\u00f3 th\u1ec3 m\u1edf vi\u00ean nang, tr\u1ed9n ph\u1ea7n b\u1ed9t thu\u1ed1c b\u00ean trong v\u1edbi 1 th\u00eca c\u00e0 ph\u00ea s\u1ed1t t\u00e1o (\u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng ho\u1eb7c l\u00e0m l\u1ea1nh) v\u00e0 u\u1ed1ng ngay v\u1edbi n\u01b0\u1edbc. H\u1ed7n h\u1ee3p c\u00f3 th\u1ec3 b\u1ea3o qu\u1ea3n trong t\u1ee7 l\u1ea1nh (2\u20138\u00b0C) t\u1ed1i \u0111a 6 gi\u1edd tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<figure id=\"attachment_143872\" aria-describedby=\"caption-attachment-143872\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-143872\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100.jpg\" alt=\"Celofen 100\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Celofen-100-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-143872\" class=\"wp-caption-text\">Thu\u1ed1c Celofen 100 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam<\/figcaption><\/figure>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Celofen 100 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi Celecoxib v\u00e0 t\u00e1 d\u01b0\u1ee3c c\u00f3 trong Celofen<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng v\u1edbi sulfonamid.<\/p>\n<p>B\u1ec7nh nh\u00e2n lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng ti\u1ebfn tri\u1ec3n ho\u1eb7c ch\u1ea3y m\u00e1u ti\u00eau h\u00f3a.<\/p>\n<p>Ng\u01b0\u1eddi t\u1eebng b\u1ecb hen, m\u1ec1 \u0111ay, ph\u00f9 m\u1ea1ch ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng sau khi d\u00f9ng aspirin ho\u1eb7c NSAID kh\u00e1c.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai ho\u1eb7c c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u1ebfu kh\u00f4ng \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai an to\u00e0n.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan n\u1eb7ng (albumin &lt;25 g\/L ho\u1eb7c \u0111i\u1ec3m Child-Pugh \u226510).<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 Clcr &lt;30 ml\/ph\u00fat<\/p>\n<p>Ng\u01b0\u1eddi m\u1eafc vi\u00eam ru\u1ed9t, suy tim sung huy\u1ebft (NYHA II\u2013IV) ho\u1eb7c b\u1ec7nh m\u1ea1ch v\u00e0nh, b\u1ec7nh m\u1ea1ch n\u00e3o, b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch ngo\u1ea1i bi\u00ean.<\/p>\n<h3>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h3>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Vi\u1ec7c d\u00f9ng Celofen 100 k\u00e9o d\u00e0i c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch nghi\u00eam tr\u1ecdng nh\u01b0 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111au th\u1eaft ng\u1ef1c, \u0111\u1ed9t qu\u1ef5 ho\u1eb7c huy\u1ebft kh\u1ed1i.<\/p>\n<p>Thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 g\u00e2y lo\u00e9t, xu\u1ea5t huy\u1ebft ho\u1eb7c th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh d\u1ea1 d\u00e0y.<\/p>\n<p>Celecoxib c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1eb7c che khu\u1ea5t tri\u1ec7u ch\u1ee9ng s\u1ed1t v\u00e0 vi\u00eam, n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi \u0111\u00e1nh gi\u00e1 t\u00ecnh tr\u1ea1ng b\u1ec7nh.<\/p>\n<p>Thu\u1ed1c ch\u1ee9a lactose monohydrat, kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi c\u00f3 r\u1ed1i lo\u1ea1n dung n\u1ea1p galactose, thi\u1ebfu men lactase to\u00e0n ph\u1ea7n ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose.<\/p>\n<p>M\u1ed7i vi\u00ean ch\u1ee9a l\u01b0\u1ee3ng natri r\u1ea5t th\u1ea5p (d\u01b0\u1edbi 23 mg), \u0111\u01b0\u1ee3c xem l\u00e0 \u201ckh\u00f4ng ch\u1ee9a natri\u201d.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Celecoxib, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n. C\u00e1c tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng ghi nh\u1eadn bao g\u1ed3m \u0111au \u0111\u1ea7u, \u0111au v\u00f9ng b\u1ee5ng, kh\u00f3 ti\u00eau, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, \u0111\u1ea7y h\u01a1i v\u00e0 r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7.<\/p>\n<p>Ngo\u00e0i ra, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u00f2n xu\u1ea5t hi\u1ec7n ch\u00f3ng m\u1eb7t, ng\u1ea5t, t\u0103ng huy\u1ebft \u00e1p, suy tim, suy th\u1eadn, t\u1ee9c ng\u1ef1c, \u00f9 tai, lo\u00e9t ho\u1eb7c xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, nh\u00ecn m\u1edd, m\u1eabn c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng, t\u0103ng c\u00e2n, gi\u1eef n\u01b0\u1edbc, c\u1ea3m gi\u00e1c y\u1ebfu, ho\u1eb7c c\u00f3 bi\u1ec3u hi\u1ec7n gi\u1ed1ng c\u00fam. C\u00e1c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng v\u1edbi celecoxib c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra, v\u00ec v\u1eady n\u1ebfu xu\u1ea5t hi\u1ec7n b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u b\u1ea5t th\u01b0\u1eddng n\u00e0o, ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n ng\u1eebng thu\u1ed1c v\u00e0 th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 \u0111\u1ec3 \u0111\u01b0\u1ee3c x\u1eed tr\u00ed k\u1ecbp th\u1eddi.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p><em><strong>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/strong><\/em><\/p>\n<p>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u: Celecoxib c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a warfarin v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng kh\u00e1c, g\u00e2y nguy c\u01a1 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i. C\u1ea7n theo d\u00f5i th\u1eddi gian prothrombin (INR) th\u01b0\u1eddng xuy\u00ean trong giai \u0111o\u1ea1n \u0111\u1ea7u d\u00f9ng ph\u1ed1i h\u1ee3p.<\/p>\n<p>Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p: NSAID, bao g\u1ed3m celecoxib, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p nh\u01b0 thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n ACE, thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II, thu\u1ed1c l\u1ee3i ti\u1ec3u ho\u1eb7c thu\u1ed1c ch\u1eb9n beta. Nguy c\u01a1 suy th\u1eadn c\u1ea5p c\u00f3 th\u1ec3 t\u0103ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi, do \u0111\u00f3 c\u1ea7n \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c b\u00f9 n\u01b0\u1edbc v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3.<\/p>\n<p>Ciclosporin v\u00e0 Tacrolimus: Khi d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi celecoxib c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn, c\u1ea7n gi\u00e1m s\u00e1t ch\u1ee9c n\u0103ng th\u1eadn ch\u1eb7t ch\u1ebd.<\/p>\n<p>Acid acetylsalicylic: Khi s\u1eed d\u1ee5ng c\u00f9ng aspirin li\u1ec1u th\u1ea5p, celecoxib kh\u00f4ng thay th\u1ebf \u0111\u01b0\u1ee3c vai tr\u00f2 d\u1ef1 ph\u00f2ng tim m\u1ea1ch c\u1ee7a aspirin, \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng nguy c\u01a1 lo\u00e9t ho\u1eb7c xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a.<\/p>\n<p><em><strong>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/strong><\/em><\/p>\n<p>\u1ea2nh h\u01b0\u1edfng c\u1ee7a celecoxib l\u00ean thu\u1ed1c kh\u00e1c: Celecoxib \u1ee9c ch\u1ebf enzym CYP2D6, c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua enzym n\u00e0y nh\u01b0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng, SSRI, thu\u1ed1c an th\u1ea7n kinh ho\u1eb7c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp. C\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u khi ph\u1ed1i h\u1ee3p.<br \/>\nCelecoxib c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf CYP2C19 tr\u00ean th\u1ef1c nghi\u1ec7m in vitro, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c thu\u1ed1c nh\u01b0 diazepam ho\u1eb7c citalopram, tuy nhi\u00ean \u00fd ngh\u0129a l\u00e2m s\u00e0ng ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5.<\/p>\n<p>Khi d\u00f9ng chung v\u1edbi lithi, celecoxib c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi trong huy\u1ebft t\u01b0\u01a1ng (Cmax t\u0103ng 16%, AUC t\u0103ng 18%), do \u0111\u00f3 c\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 lithi khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Trong khi \u0111\u00f3, celecoxib kh\u00f4ng \u1ea3nh h\u01b0\u1edfng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng \u0111\u1ebfn thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng, tolbutamid ho\u1eb7c glibenclamid.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c kh\u00e1c l\u00ean celecoxib: Fluconazol \u2013 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP2C9 \u2013 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 celecoxib trong huy\u1ebft t\u01b0\u01a1ng, do \u0111\u00f3 c\u1ea7n d\u00f9ng li\u1ec1u b\u1eb1ng m\u1ed9t n\u1eeda li\u1ec1u khuy\u1ebfn c\u00e1o khi ph\u1ed1i h\u1ee3p. Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng enzym nh\u01b0 rifampicin, carbamazepin ho\u1eb7c barbiturat c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 celecoxib. Ketoconazol v\u00e0 thu\u1ed1c kh\u00e1ng acid kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a celecoxib.<\/p>\n<p>Nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c hi\u1ec7n ch\u1ec9 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p><em><strong>Ph\u1ee5 n\u1eef mang thai<\/strong><\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt (chu\u1ed9t v\u00e0 th\u1ecf) cho th\u1ea5y celecoxib c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c t\u00ednh sinh s\u1ea3n v\u00e0 d\u1ecb t\u1eadt thai nhi. Vi\u1ec7c \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 s\u1ea3y thai, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn \u1edf thai nhi, gi\u1ea3m ho\u1eb7c m\u1ea5t n\u01b0\u1edbc \u1ed1i, \u0111\u1eb7c bi\u1ec7t trong tam c\u00e1 nguy\u1ec7t th\u1ee9 hai v\u00e0 ba. Ngo\u00e0i ra, thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y v\u00f4 l\u1ef1c c\u01a1 t\u1eed cung ho\u1eb7c \u0111\u00f3ng s\u1edbm \u1ed1ng \u0111\u1ed9ng m\u1ea1ch. Celecoxib b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u1ebfu kh\u00f4ng \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai an to\u00e0n. N\u1ebfu mang thai trong khi \u0111i\u1ec1u tr\u1ecb, c\u1ea7n ng\u1eebng thu\u1ed1c ngay.<\/p>\n<p><em><strong>Ph\u1ee5 n\u1eef cho con b\u00fa<\/strong><\/em><\/p>\n<p>Celecoxib \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa chu\u1ed9t m\u1eb9 v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng huy\u1ebft t\u01b0\u01a1ng, v\u00e0 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf c\u0169ng \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong s\u1eefa ng\u01b0\u1eddi. Do nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb s\u01a1 sinh, ph\u1ee5 n\u1eef \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng celecoxib kh\u00f4ng n\u00ean cho con b\u00fa.<\/p>\n<p><em><strong>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n<\/strong><\/em><\/p>\n<p>NSAID, bao g\u1ed3m celecoxib, c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ho\u1eb7c tr\u00ec ho\u00e3n s\u1ef1 r\u1ee5ng tr\u1ee9ng, l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng th\u1ee5 thai t\u1ea1m th\u1eddi. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y th\u01b0\u1eddng h\u1ed3i ph\u1ee5c sau khi ng\u1eebng thu\u1ed1c.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Celecoxib c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7 ho\u1eb7c hoa m\u1eaft nh\u1eb9 \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi d\u00f9ng. Do \u0111\u00f3, nh\u1eefng b\u1ec7nh nh\u00e2n g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y n\u00ean tr\u00e1nh l\u00e1i xe, \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c ho\u1eb7c th\u1ef1c hi\u1ec7n c\u00f4ng vi\u1ec7c c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o cao cho \u0111\u1ebfn khi x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u1eadp trung c\u1ee7a h\u1ecd.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Hi\u1ec7n ch\u01b0a ghi nh\u1eadn tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u nghi\u00eam tr\u1ecdng tr\u00ean l\u00e2m s\u00e0ng. \u1ede ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, d\u00f9ng \u0111\u01a1n li\u1ec1u \u0111\u1ebfn 1200 mg ho\u1eb7c li\u1ec1u chia 1200 mg\/ng\u00e0y trong 9 ng\u00e0y kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. N\u1ebfu nghi ng\u1edd d\u00f9ng qu\u00e1 li\u1ec1u, c\u1ea7n ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 nh\u01b0 r\u1eeda d\u1ea1 d\u00e0y, theo d\u00f5i d\u1ea5u hi\u1ec7u sinh t\u1ed3n v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng n\u1ebfu c\u1ea7n. Do celecoxib g\u1eafn m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, th\u1ea9m t\u00e1ch m\u00e1u kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c lo\u1ea1i b\u1ecf thu\u1ed1c kh\u1ecfi c\u01a1 th\u1ec3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Celofen 100 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Celofen 100 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Celofen 100 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Celofen 100 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/stadloric-100\/\">Stadloric 100<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Celecoxib h\u00e0m l\u01b0\u1ee3ng 100mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Li\u00ean doanh Stellapharm, c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/locobile-200\/\">Locobile 200<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Celecoxib h\u00e0m l\u01b0\u1ee3ng 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi M\/s Windlas Biotech Limited, c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Celofen 100 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/To-huong-dan-su-dung-celofen-100-vnras-.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 8 th\u00e1ng 10 n\u0103m 2025<\/li>\n<li>Gong L, Thorn CF, Bertagnolli MM, Grosser T, Altman RB, Klein TE (2012). Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. Truy c\u1eadp ng\u00e0y 8 th\u00e1ng 10 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3303994\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3303994\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Celofen 100 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, h\u1ea1 vi\u00eam ch\u1ecdn l\u1ecdc tr\u00ean enzym COX-2, d\u00f9ng cho b\u1ec7nh l\u00fd vi\u00eam x\u01b0\u01a1ng kh\u1edbp, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp, \u0111au c\u1ea5p v\u00e0 \u0111au b\u1ee5ng kinh<\/p>\n","protected":false},"author":1,"featured_media":143876,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-143871","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/143871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=143871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/143876"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=143871"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=143871"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=143871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}