{"id":143487,"date":"2025-10-07T11:59:29","date_gmt":"2025-10-07T04:59:29","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=143487"},"modified":"2025-10-07T12:03:04","modified_gmt":"2025-10-07T05:03:04","slug":"pyzacar-50","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/pyzacar-50\/","title":{"rendered":"Pyzacar 50"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Pyzacar 50 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n Pymepharco c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110150925 (S\u0110K c\u0169: VD-26431-17)<\/strong><\/p>\n<h2>Pyzacar 50 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Pyzacar 50<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Losartan kali:&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;50mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Cellulose vi tinh th\u1ec3, lactose monohydrat, crospovidon, acid stearic, colloidal anhydrous silica, HPMC, PEG 400, PEG 6000, magnesi stearat, titan dioxid, indigo carmine lake, D&amp;C Yellow 10 lake.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110150925 (S\u0110K c\u0169: VD-26431-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 02 v\u1ec9 x 15 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Pyzacar 50<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Pyzacar 50 ch\u1ee9a ho\u1ea1t ch\u1ea5t Losartan, m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 angiotensin II typ AT\u2081.<\/p>\n<p>Thu\u1ed1c v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a n\u00f3 ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng co m\u1ea1ch v\u00e0 k\u00edch th\u00edch ti\u1ebft aldosteron m\u00e0 angiotensin II g\u00e2y ra, t\u1eeb \u0111\u00f3 gi\u00fap gi\u00e3n n\u1edf m\u1ea1ch m\u00e1u, gi\u1ea3m s\u1ee9c c\u1ea3n ngo\u1ea1i bi\u00ean v\u00e0 \u1ed5n \u0111\u1ecbnh huy\u1ebft \u00e1p.<\/p>\n<p>Nh\u1edd c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf t\u1ea1i th\u1ee5 th\u1ec3 m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn men chuy\u1ec3n, Losartan kh\u00f4ng g\u00e2y ho khan \u2013 m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p \u1edf nh\u00f3m \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI).<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Sau khi u\u1ed1ng, ho\u1ea1t ch\u1ea5t ch\u00ednh \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 tr\u1ea3i qua chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u m\u1ea1nh t\u1ea1i gan th\u00f4ng qua h\u1ec7 enzym cytochrome P450 (CYP2C9 v\u00e0 CYP3A4).<\/p>\n<p>Sinh kh\u1ea3 d\u1ee5ng: Kho\u1ea3ng m\u1ed9t ph\u1ea7n ba li\u1ec1u u\u1ed1ng \u0111\u01b0\u1ee3c h\u1ea5p thu, trong \u0111\u00f3 c\u00f3 kho\u1ea3ng 14% \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n<p>Th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh: Losartan \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 1 gi\u1edd, c\u00f2n ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t t\u00ednh \u0111\u1ea1t \u0111\u1ec9nh sau 3\u20134 gi\u1edd.<\/p>\n<p>Li\u00ean k\u1ebft protein: C\u1ea3 Losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 \u0111\u1ec1u g\u1eafn m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (&gt;99%), ch\u1ee7 y\u1ebfu l\u00e0 albumin.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a Losartan kho\u1ea3ng 2 gi\u1edd, c\u00f2n ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh k\u00e9o d\u00e0i 6\u20139 gi\u1edd.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c kh\u00f4ng qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, v\u00ec v\u1eady h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n<h2>Thu\u1ed1c Pyzacar 50 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p: D\u00f9ng cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 6 tu\u1ed5i tr\u1edf l\u00ean<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2: \u0110\u1eb7c bi\u1ec7t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 k\u00e8m t\u0103ng huy\u1ebft \u00e1p v\u00e0 protein ni\u1ec7u \u2265 0,5 g\/ng\u00e0y, gi\u00fap l\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n suy th\u1eadn.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb suy tim m\u1ea1n t\u00ednh: \u00c1p d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng dung n\u1ea1p ho\u1eb7c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI).<\/p>\n<p>Gi\u1ea3m nguy c\u01a1 \u0111\u1ed9t qu\u1ef5: D\u00e0nh cho b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p c\u00f3 ph\u00ec \u0111\u1ea1i th\u1ea5t tr\u00e1i<\/p>\n<figure id=\"attachment_143685\" aria-describedby=\"caption-attachment-143685\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-143685\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50.jpg\" alt=\"Pyzacar 50\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Pyzacar-50-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-143685\" class=\"wp-caption-text\">Thu\u1ed1c Pyzacar 50 c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p, c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng tim v\u00e0 b\u1ea3o v\u1ec7 th\u1eadn<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p: Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u00f4ng th\u01b0\u1eddng ng\u00e0y 1 vi\u00ean Pyzacar 50, c\u00f3 th\u1ec3 t\u0103ng l\u00ean 2 vi\u00ean 2 l\u1ea7n m\u1ed7i ng\u00e0y t\u00f9y \u0111\u00e1p \u1ee9ng huy\u1ebft \u00e1p.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng: ng\u00e0y 1 vi\u00ean Pyzacar 50, t\u0103ng \u0111\u1ebfn 2 vi\u00ean 2 l\u1ea7n m\u1ed7i ng\u00e0y sau kho\u1ea3ng 1 th\u00e1ng n\u1ebfu c\u1ea7n.<\/p>\n<p>Suy tim m\u1ea1n: B\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u th\u1ea5p 12,5mg losartan m\u1ed7i ng\u00e0y, sau \u0111\u00f3 t\u0103ng d\u1ea7n \u0111\u1ebfn li\u1ec1u duy tr\u00ec t\u00f9y \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>Ng\u01b0\u1eddi gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n (nh\u01b0 \u0111ang d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u li\u1ec1u cao): Kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 25mg losartan m\u1ed7i ng\u00e0y.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: Li\u1ec1u kh\u1edfi \u0111\u1ea7u m\u1ed7i ng\u00e0y v\u1edbi 25 mg<\/p>\n<p>Tr\u1ebb em 6\u201318 tu\u1ed5i:<\/p>\n<ul>\n<li>C\u00e2n n\u1eb7ng 20\u201350 kg: 25 mg d\u00f9ng 1 l\u1ea7n m\u1ed7i ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ebfn ng\u00e0y 1 vi\u00ean Pyzacar 50 n\u1ebfu c\u1ea7n.<\/li>\n<li>Tr\u00ean 50 kg: ng\u00e0y 1 vi\u00ean Pyzacar 50, t\u1ed1i \u0111a 2 vi\u00ean<\/li>\n<li><span style=\"font-size: 14.4px;\">Kh\u00f4ng d\u00f9ng cho tr\u1ebb &lt;6 tu\u1ed5i, tr\u1ebb c\u00f3 \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn &lt;30 ml\/ph\u00fat\/1,73 m\u00b2 ho\u1eb7c b\u1ecb suy gan.<\/span><\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>U\u1ed1ng nguy\u00ean <strong>vi\u00ean n\u00e9n bao phim Pyzacar 50<\/strong> v\u1edbi n\u01b0\u1edbc, c\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/p>\n<p>Kh\u00f4ng t\u1ef1 \u00fd t\u0103ng ho\u1eb7c gi\u1ea3m li\u1ec1u Pyzacar 50 khi ch\u01b0a c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Pyzacar 50 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi Losartan ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Thai k\u1ef3 3 th\u00e1ng gi\u1eefa<\/p>\n<p>Thai k\u1ef3 3 th\u00e1ng cu\u1ed1i<\/p>\n<p>B\u1ec7nh nh\u00e2n gan suy giai \u0111o\u1ea1n n\u1eb7ng.<\/p>\n<p>Kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ee9a Aliskiren \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn, v\u00ec c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 h\u1ea1 huy\u1ebft \u00e1p, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 t\u0103ng kali huy\u1ebft.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n, m\u1ea5t n\u01b0\u1edbc ho\u1eb7c gi\u1ea3m natri huy\u1ebft, do nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 n\u1ed3ng \u0111\u1ed9 kali m\u00e1u \u0111\u1ecbnh k\u1ef3, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh th\u1eadn ho\u1eb7c \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>Kh\u00f4ng ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali hay ch\u1ebf ph\u1ea9m b\u1ed5 sung kali, v\u00ec c\u00f3 th\u1ec3 g\u00e2y t\u0103ng kali huy\u1ebft.<\/p>\n<p>S\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p h\u01a1n cho ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed suy gan nh\u1eb9 \u2013 v\u1eeba, tr\u00e1nh d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n<p>\u1ede ng\u01b0\u1eddi h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn hai b\u00ean ho\u1eb7c ch\u1ec9 c\u00f3 m\u1ed9t th\u1eadn, vi\u1ec7c d\u00f9ng Losartan c\u00f3 th\u1ec3 l\u00e0m t\u0103ng ure v\u00e0 creatinin huy\u1ebft thanh; n\u00ean gi\u00e1m s\u00e1t ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p>Tr\u00e1nh ph\u1ed1i h\u1ee3p \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI) do t\u0103ng nguy c\u01a1 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n h\u1eb9p van \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ho\u1eb7c b\u1ec7nh c\u01a1 tim ph\u00ec \u0111\u1ea1i.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u01b0\u1eddng aldosteron nguy\u00ean ph\u00e1t kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi thu\u1ed1c n\u00e0y.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 ho\u1eb7c r\u1ed1i lo\u1ea1n m\u1ea1ch m\u00e1u n\u00e3o, vi\u1ec7c h\u1ea1 huy\u1ebft \u00e1p qu\u00e1 nhanh c\u00f3 th\u1ec3 g\u00e2y nh\u1ed3i m\u00e1u c\u01a1 tim ho\u1eb7c \u0111\u1ed9t qu\u1ef5.<\/p>\n<p>Thu\u1ed1c ch\u1ee9a lactose, n\u00ean kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu men lactase ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose.<\/p>\n<p>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u an to\u00e0n tr\u00ean b\u1ec7nh nh\u00e2n gh\u00e9p th\u1eadn, n\u00ean ch\u1ec9 d\u00f9ng khi th\u1eadt c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o ph\u1ed1i h\u1ee3p \u1ee9c ch\u1ebf k\u00e9p h\u1ec7 renin\u2013angiotensin\u2013aldosteron (RAAS) do nguy c\u01a1 t\u0103ng kali m\u00e1u v\u00e0 suy th\u1eadn.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh: th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, m\u1ea5t ng\u1ee7 ho\u1eb7c c\u1ea3m gi\u00e1c bu\u1ed3n ng\u1ee7.<\/p>\n<p>R\u1ed1i lo\u1ea1n tim m\u1ea1ch: c\u00f3 th\u1ec3 x\u1ea3y ra \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, \u0111au th\u1eaft ng\u1ef1c, h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf, nh\u1ecbp tim nhanh ho\u1eb7c ch\u1eadm.<\/p>\n<p>R\u1ed1i lo\u1ea1n m\u1ea1ch m\u00e1u: h\u1ea1 huy\u1ebft \u00e1p t\u1ef1 ph\u00e1t, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n.<\/p>\n<p>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a: \u0111\u00f4i khi ghi nh\u1eadn \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, bu\u1ed3n n\u00f4n, n\u00f4n ho\u1eb7c ti\u00eau ch\u1ea3y.<\/p>\n<p>R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da: ph\u00e1t ban, ng\u1ee9a ho\u1eb7c n\u1ed5i m\u00e0y \u0111ay.<\/p>\n<p>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a: t\u0103ng kali huy\u1ebft, t\u0103ng ur\u00ea huy\u1ebft, t\u0103ng creatinin huy\u1ebft thanh; hi\u1ebfm h\u01a1n l\u00e0 t\u0103ng men gan (ALT), th\u01b0\u1eddng tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng khi ng\u1eebng thu\u1ed1c.<\/p>\n<p>R\u1ed1i lo\u1ea1n chung: m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, ph\u00f9 nh\u1eb9, c\u1ea3m gi\u00e1c y\u1ebfu s\u1ee9c.<br \/>\n\u1ede b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 b\u1ec7nh th\u1eadn, c\u00f3 th\u1ec3 g\u1eb7p h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c t\u0103ng kali huy\u1ebft; \u1edf ng\u01b0\u1eddi suy tim m\u1ea1n, \u0111\u00f4i khi xu\u1ea5t hi\u1ec7n kh\u00f3 th\u1edf, r\u1ed1i lo\u1ea1n nh\u1ecbp tim ho\u1eb7c suy th\u1eadn.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Cimetidin: l\u00e0m t\u0103ng nh\u1eb9 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a losartan nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n<p>Phenobarbital: l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u1ee7a losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t t\u00ednh kho\u1ea3ng 20%.<\/p>\n<p>Fluconazol (\u1ee9c ch\u1ebf CYP2C9): gi\u1ea3m kho\u1ea3ng 50% n\u1ed3ng \u0111\u1ed9 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n<p>Rifampicin (c\u1ea3m \u1ee9ng CYP2C9): l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t t\u00ednh kho\u1ea3ng 40%.<\/p>\n<p>Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c: c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u00e1p c\u1ee7a Pyzacar 50, do \u0111\u00f3 c\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng, thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n, amifostin ho\u1eb7c thu\u1ed1c gi\u00e3n m\u1ea1ch: c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, heparin, c\u00e1c ch\u1ebf ph\u1ea9m b\u1ed5 sung ho\u1eb7c thay th\u1ebf c\u00f3 ch\u1ee9a kali: ph\u1ed1i h\u1ee3p v\u1edbi Pyzacar 50 c\u00f3 th\u1ec3 g\u00e2y t\u0103ng kali huy\u1ebft, n\u00ean tr\u00e1nh d\u00f9ng c\u00f9ng.<\/p>\n<p>Mu\u1ed1i lithi: khi d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft thanh, c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd n\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i ph\u1ed1i h\u1ee3p.<\/p>\n<p>NSAID (bao g\u1ed3m c\u1ea3 \u1ee9c ch\u1ebf COX-2 v\u00e0 aspirin li\u1ec1u kh\u00e1ng vi\u00eam): c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p, \u0111\u1ed3ng th\u1eddi t\u0103ng nguy c\u01a1 suy th\u1eadn c\u1ea5p, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c c\u00f3 b\u1ec7nh th\u1eadn s\u1eb5n. Khi ph\u1ed1i h\u1ee3p c\u1ea7n \u0111\u1ea3m b\u1ea3o \u0111\u1ee7 n\u01b0\u1edbc v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Th\u1eddi k\u1ef3 mang thai: c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 renin \u2013 angiotensin, trong \u0111\u00f3 c\u00f3 losartan, c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng nghi\u00eam tr\u1ecdng cho thai nhi (nh\u01b0 gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, thi\u1ec3u \u1ed1i, th\u1eadm ch\u00ed t\u1eed vong) khi s\u1eed d\u1ee5ng trong 3 th\u00e1ng gi\u1eefa v\u00e0 3 th\u00e1ng cu\u1ed1i thai k\u1ef3. Khi ph\u00e1t hi\u1ec7n c\u00f3 thai, ph\u1ea3i ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c.<\/p>\n<p>Ba th\u00e1ng \u0111\u1ea7u thai k\u1ef3: ch\u01b0a c\u00f3 b\u1eb1ng ch\u1ee9ng r\u00f5 r\u00e0ng v\u1ec1 nguy c\u01a1, tuy nhi\u00ean v\u1eabn c\u1ea7n tr\u00e1nh d\u00f9ng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n.<\/p>\n<p>Th\u1eddi k\u1ef3 cho con b\u00fa: ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c losartan c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng. V\u00ec kh\u1ea3 n\u0103ng g\u00e2y h\u1ea1i cho tr\u1ebb b\u00fa m\u1eb9, n\u00ean c\u00e2n nh\u1eafc ng\u1eebng cho b\u00fa ho\u1eb7c ng\u1eebng thu\u1ed1c t\u00f9y theo m\u1ee9c \u0111\u1ed9 c\u1ea7n thi\u1ebft c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi m\u1eb9.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u ch\u00ednh th\u1ee9c v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a Pyzacar 50 \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c. Tuy nhi\u00ean, thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t ho\u1eb7c m\u1ec7t m\u1ecfi \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi m\u1edbi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c sau khi t\u0103ng li\u1ec1u. V\u00ec v\u1eady, c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 tr\u00e1nh c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o cao n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Khi d\u00f9ng qu\u00e1 li\u1ec1u losartan, c\u00e1c bi\u1ec3u hi\u1ec7n th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 h\u1ea1 huy\u1ebft \u00e1p r\u00f5 r\u1ec7t v\u00e0 r\u1ed1i lo\u1ea1n nh\u1ecbp tim (nh\u1ecbp nhanh ho\u1eb7c ch\u1eadm).<\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ec7nh b\u1ecb t\u1ee5t huy\u1ebft \u00e1p, c\u1ea7n \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 ph\u00f9 h\u1ee3p nh\u01b0 \u0111\u1eb7t n\u1eb1m \u0111\u1ea7u th\u1ea5p, truy\u1ec1n d\u1ecbch n\u1ebfu c\u1ea7n thi\u1ebft \u0111\u1ec3 duy tr\u00ec huy\u1ebft \u00e1p \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>C\u1ea3 losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c kh\u00f4ng th\u1ec3 b\u1ecb lo\u1ea1i b\u1ecf b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p th\u1ea9m t\u00e1ch m\u00e1u, do \u0111\u00f3 x\u1eed tr\u00ed ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 to\u00e0n th\u00e2n cho \u0111\u1ebfn khi ng\u01b0\u1eddi b\u1ec7nh h\u1ed3i ph\u1ee5c ho\u00e0n to\u00e0n.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Pyzacar 50 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Pyzacar 50 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Pyzacar 50 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p><span style=\"font-size: 14.4px;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Pyzacar 50 nh\u01b0:<\/span><\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/rotalzon-50mg\/\">Rotalzon 50mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Losartan potassium h\u00e0m l\u01b0\u1ee3ng 50mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Atlantic Pharma \u2013 Produ\u00e7\u00f5es Farmac\u00eauticas S.A, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/lipcor-50mg\/\">LIPCOR 50mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Losartan potassium h\u00e0m l\u01b0\u1ee3ng 50mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH MTV D\u01b0\u1ee3c ph\u1ea9m DHG, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Pyzacar 50 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/To-huong-dan-su-dung-Pyzacar-50-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 7 th\u00e1ng 10 n\u0103m 2025<\/li>\n<li>Sica DA, Gehr TW, Ghosh S (2005). Clinical pharmacokinetics of losartan. Clin Pharmacokinet. Truy c\u1eadp ng\u00e0y 7 th\u00e1ng 10 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16029066\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/16029066\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Pyzacar 50 \u1ee9c ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a angiotensin II \u2013 m\u1ed9t ch\u1ea5t g\u00e2y co m\u1ea1ch v\u00e0 t\u0103ng ti\u1ebft aldosteron, gi\u00fap m\u1ea1ch m\u00e1u gi\u00e3n ra, gi\u1ea3m g\u00e1nh n\u1eb7ng cho tim v\u00e0 h\u1ea1 huy\u1ebft \u00e1p hi\u1ec7u qu\u1ea3.<\/p>\n","protected":false},"author":1,"featured_media":143680,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-143487","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/143487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=143487"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/143680"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=143487"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=143487"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=143487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}