{"id":143125,"date":"2025-10-03T16:04:11","date_gmt":"2025-10-03T09:04:11","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=143125"},"modified":"2025-10-03T17:38:28","modified_gmt":"2025-10-03T10:38:28","slug":"glucovance-500mg-2-5-mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/glucovance-500mg-2-5-mg\/","title":{"rendered":"Glucovance 500mg\/2.5 mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m Glucovance 500mg\/2.5 mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Merck Sante s.a.s., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-20022-16.<\/strong><\/p>\n<h2>Glucovance 500mg\/2.5 mg l\u00e0 s\u1ea3n ph\u1ea9m g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean<strong> Glucovance 500mg\/2.5 mg <\/strong>c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Metformin 500mg<\/li>\n<li>Glibenclamide 2.5mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K : VN-20022-16<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i : H\u1ed9p 2 v\u1ec9 x 15 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9 : Ph\u00e1p<\/p>\n<h2>Thu\u1ed1c Glucovance 500mg\/2.5 mg c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Metformin l\u00e0 biguanide ch\u1ed1ng t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft kh\u00f4ng k\u00edch th\u00edch ti\u1ebft insulin. T\u00e1c d\u1ee5ng ch\u00ednh g\u1ed3m gi\u1ea3m t\u00e2n t\u1ea1o glucose \u1edf gan, t\u0103ng nh\u1ea1y c\u1ea3m insulin \u1edf c\u01a1 x\u01b0\u01a1ng d\u1eabn \u0111\u1ebfn t\u0103ng v\u1eadn chuy\u1ec3n v\u00e0 s\u1eed d\u1ee5ng glucose ngo\u1ea1i bi\u00ean, v\u00e0 l\u00e0m ch\u1eadm h\u1ea5p thu glucose \u1edf ru\u1ed9t. Metformin c\u00f2n c\u00f3 l\u1ee3i tr\u00ean chuy\u1ec3n h\u00f3a lipid v\u1edbi gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n LDL v\u00e0 triglycerid \u0111\u01b0\u1ee3c ghi nh\u1eadn trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng.<\/p>\n<p>Glibenclamid l\u00e0 sulfonylurea th\u1ebf h\u1ec7 hai k\u00edch th\u00edch t\u1ebf b\u00e0o beta t\u1ee5y gi\u1ea3i ph\u00f3ng insulin. Thu\u1ed1c t\u0103ng \u0111\u00e1p \u1ee9ng insulin sau b\u1eefa \u0103n v\u00e0 duy tr\u00ec b\u00e0i ti\u1ebft C peptide sau \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n. Do c\u01a1 ch\u1ebf kh\u00e1c nhau, glibenclamid v\u00e0 metformin c\u00f3 t\u00e1c d\u1ee5ng b\u1ed5 sung khi ph\u1ed1i h\u1ee3p.<\/p>\n<h3>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu : Metformin \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 2,5 gi\u1edd sau khi u\u1ed1ng. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 50 \u0111\u1ebfn 60% v\u00e0 h\u1ea5p thu c\u00f3 th\u1ec3 b\u00e3o h\u00f2a m\u1ed9t ph\u1ea7n.<\/p>\n<p>Ph\u00e2n b\u1ed1 : Metformin \u00edt g\u1eafn protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 ph\u00e2n b\u1ed1 r\u1ed9ng v\u00e0o m\u00f4 bao g\u1ed3m h\u1ed3ng c\u1ea7u.<\/p>\n<p>Chuy\u1ec3n h\u00f3a : Metformin h\u1ea7u nh\u01b0 kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a \u0111\u00e1ng k\u1ec3.<\/p>\n<p>Th\u1ea3i tr\u1eeb : Ph\u1ea7n kh\u00f4ng h\u1ea5p thu \u0111\u01b0\u1ee3c th\u1ea3i ra ph\u00e2n kho\u1ea3ng 20 \u0111\u1ebfn 30%. Metformin \u0111\u00e0o th\u1ea3i nguy\u00ean d\u1ea1ng qua th\u1eadn b\u1eb1ng b\u00e0i ti\u1ebft \u1ed1ng th\u1eadn t\u00edch c\u1ef1c. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 6,5 gi\u1edd.<\/p>\n<h2>Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a s\u1ea3n ph\u1ea9m thu\u1ed1c Glucovance 500mg\/2.5 mg?<\/h2>\n<p><strong>Glucovance 500mg\/2.5 mg Metformin <\/strong>\u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong :<\/p>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 \u1edf ng\u01b0\u1eddi l\u1edbn khi ch\u1ebf \u0111\u1ed9 \u0103n v\u00e0 t\u1eadp luy\u1ec7n kh\u00f4ng \u0111\u1ee7 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/li>\n<li>S\u1eed d\u1ee5ng khi b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u1ea1t m\u1ee5c ti\u00eau \u0111\u01b0\u1eddng huy\u1ebft v\u1edbi \u0111\u01a1n tr\u1ecb metformin ho\u1eb7c glibenclamid.<\/li>\n<li>C\u00f3 th\u1ec3 thay th\u1ebf ph\u00e1c \u0111\u1ed3 k\u1ebft h\u1ee3p t\u00e1ch r\u1eddi metformin v\u00e0 glibenclamid \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e3 \u1ed5n \u0111\u1ecbnh v\u00e0 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1t.<\/li>\n<\/ul>\n<figure id=\"attachment_143126\" aria-describedby=\"caption-attachment-143126\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-143126\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2.jpg\" alt=\"Glucovance 500mg\/2.5 mg \u0111i\u1ec1u tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng type 2\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/glucovance-500mg-2.5-mg-dieu-tri-benh-tieu-duong-type-2-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-143126\" class=\"wp-caption-text\">Glucovance 500mg\/2.5 mg \u0111i\u1ec1u tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng type 2<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Glucovance 500mg\/2.5 mg<\/h2>\n<h4>Ng\u01b0\u1eddi l\u1edbn<\/h4>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u : 1 vi\u00ean\/l\u1ea7n\/ng\u00e0y. \u0110\u1ec3 tr\u00e1nh h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, li\u1ec1u kh\u1edfi \u0111\u1ea7u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 t\u1ed5ng li\u1ec1u metformin ho\u1eb7c glibenclamide m\u00e0 b\u1ec7nh nh\u00e2n \u0111\u00e3 d\u00f9ng tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Thay th\u1ebf ph\u00e1c \u0111\u1ed3 k\u1ebft h\u1ee3p ri\u00eang l\u1ebb: b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng li\u1ec1u metformin v\u00e0 glyburide tr\u01b0\u1edbc \u0111\u00f3 tr\u00ean t\u1eebng c\u00e1 th\u1ec3, sau \u0111\u00f3 t\u0103ng d\u1ea7n theo k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>T\u0103ng li\u1ec1u n\u00ean th\u1ef1c hi\u1ec7n t\u1eebng b\u01b0\u1edbc c\u00e1ch 2 tu\u1ea7n ho\u1eb7c l\u00e2u h\u01a1n, m\u1ed7i l\u1ea7n t\u0103ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng m\u1ed9t vi\u00ean n\u1ebfu c\u1ea7n, nh\u1eb1m gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 ti\u00eau h\u00f3a v\u00e0 gi\u1ea3m nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>Li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y: 20mg glibenclamide v\u00e0 2000mg metformin.<\/p>\n<h4>Ng\u01b0\u1eddi cao tu\u1ed5i<\/h4>\n<p>Kh\u1edfi \u0111\u1ea7u: 1 vi\u00ean\/ng\u00e0y. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u1ef1a tr\u00ean ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<h4>Tr\u1ebb em<\/h4>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho tr\u1ebb em v\u00ec \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp<\/p>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Glucovance 500mg\/2.5 mg<\/h2>\n<p>S\u1ed1 l\u1ea7n d\u00f9ng ph\u1ee5 thu\u1ed9c li\u1ec1u c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>1 l\u1ea7n m\u1ed7i ng\u00e0y: u\u1ed1ng v\u00e0o b\u1eefa s\u00e1ng cho li\u1ec1u 1 vi\u00ean m\u1ed7i ng\u00e0y.<\/p>\n<p>2 l\u1ea7n m\u1ed7i ng\u00e0y: u\u1ed1ng s\u00e1ng v\u00e0 t\u1ed1i cho li\u1ec1u 2 vi\u00ean m\u1ed7i ng\u00e0y ho\u1eb7c 4 vi\u00ean m\u1ed7i ng\u00e0y.<\/p>\n<p>3 l\u1ea7n m\u1ed7i ng\u00e0y: u\u1ed1ng s\u00e1ng tr\u01b0a t\u1ed1i cho li\u1ec1u 3 vi\u00ean m\u1ed7i ng\u00e0y.<\/p>\n<p>N\u00ean u\u1ed1ng c\u00f9ng b\u1eefa \u0103n v\u00e0 \u0111i\u1ec1u ch\u1ec9nh s\u1ed1 l\u1ea7n d\u1ef1a tr\u00ean th\u00f3i quen \u0103n u\u1ed1ng. Sau khi u\u1ed1ng, ph\u1ea3i \u0103n m\u1ed9t b\u1eefa c\u00f3 \u0111\u1ee7 carbohydrate \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 kh\u1edfi ph\u00e1t h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<h2>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Glucovance 500mg\/2.5 mg<\/h2>\n<p>Kh\u00f4ng d\u00f9ng thu\u1ed1c Glucovance 500mg\/2.5 mg trong tr\u01b0\u1eddng h\u1ee3p b\u1ecb m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1, nhi\u1ec5m toan ceton ho\u1eb7c ti\u1ec1n h\u00f4n m\u00ea \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>Suy th\u1eadn ho\u1eb7c gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 60ml m\u1ed7i ph\u00fat.<\/p>\n<p>C\u00e1c t\u00ecnh tr\u1ea1ng c\u1ea5p l\u00e0m thay \u0111\u1ed5i ch\u1ee9c n\u0103ng th\u1eadn nh\u01b0 m\u1ea5t n\u01b0\u1edbc, nhi\u1ec5m tr\u00f9ng n\u1eb7ng, s\u1ed1c ho\u1eb7c khi ph\u1ea3i ch\u1ee5p X quang c\u00f3 ti\u00eam t\u0129nh m\u1ea1ch ch\u1ea5t c\u1ea3n quang c\u00f3 iod.<\/p>\n<p>B\u1ec7nh c\u1ea5p t\u00ednh ho\u1eb7c m\u1ea1n t\u00ednh g\u00e2y thi\u1ebfu oxy m\u00f4 nh\u01b0 suy h\u00f4 h\u1ea5p, suy tim m\u1ea5t b\u00f9, nh\u1ed3i m\u00e1u c\u01a1 tim g\u1ea7n \u0111\u00e2y ho\u1eb7c s\u1ed1c.<\/p>\n<p>Suy gan.<\/p>\n<p>Nghi\u1ec7n r\u01b0\u1ee3u c\u1ea5p t\u00ednh ho\u1eb7c u\u1ed1ng r\u01b0\u1ee3u nhi\u1ec1u v\u00ec t\u0103ng nguy c\u01a1 nhi\u1ec5m acid lactic.<\/p>\n<p>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<p>K\u1ebft h\u1ee3p v\u1edbi miconazole \u0111\u01b0\u1eddng u\u1ed1ng v\u00ec c\u00f3 b\u00e1o c\u00e1o g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1eb7ng khi ph\u1ed1i h\u1ee3p v\u1edbi sulfonylurea.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng Glucovance 500mg\/2.5 mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Thu\u1ed1c Glucovance 500mg\/2.5 mg c\u00f3 th\u1ec3 g\u00e2y nhi\u1ec5m acid lactic do t\u00edch l\u0169y metformin, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn \u0111\u00e1ng k\u1ec3. Khi c\u00f3 \u0111au c\u01a1 k\u00e8m r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a n\u1eb7ng ho\u1eb7c d\u1ea5u hi\u1ec7u suy to\u00e0n tr\u1ea1ng c\u1ea7n ng\u01b0ng thu\u1ed1c v\u00e0 nh\u1eadp vi\u1ec7n \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 pH v\u00e0 n\u1ed3ng \u0111\u1ed9 lactat.<\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft. T\u0103ng li\u1ec1u t\u1eebng b\u01b0\u1edbc v\u00e0 b\u1ea3o \u0111\u1ea3m b\u1ec7nh nh\u00e2n \u0103n \u0111\u1ea7y \u0111\u1ee7 theo l\u1ecbch \u0111\u1ec3 gi\u1ea3m nguy c\u01a1. N\u1ebfu x\u1ea3y ra h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft nh\u1eb9 c\u1ea7n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng ngay; n\u1ebfu n\u1eb7ng ph\u1ea3i ti\u00eam glucose t\u0129nh m\u1ea1ch v\u00e0 chuy\u1ec3n tuy\u1ebfn.<\/p>\n<p>B\u1ec7nh nh\u00e2n ph\u1ea3i \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 thanh th\u1ea3i creatinin tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u v\u00e0 theo d\u00f5i \u0111\u1ecbnh k\u1ef3. Kh\u00f4ng kh\u1edfi \u0111\u1ea7u metformin khi eGFR d\u01b0\u1edbi kho\u1ea3ng 30mL\/ph\u00fat\/1,73m2 v\u00e0 c\u00e2n nh\u1eafc ng\u01b0ng khi eGFR gi\u1ea3m v\u1ec1 d\u01b0\u1edbi ng\u01b0\u1ee1ng an to\u00e0n. Theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1.<\/p>\n<p>T\u00f9y ch\u1ee9c n\u0103ng th\u1eadn, n\u00ean ng\u01b0ng Glucovance 500mg\/2.5 mg t\u1ea1i th\u1eddi \u0111i\u1ec3m ch\u1ee5p t\u0129nh m\u1ea1ch c\u00f3 ch\u1ea5t c\u1ea3n quang v\u00e0 kh\u00f4ng d\u00f9ng l\u1ea1i trong t\u1ed1i thi\u1ec3u 48 gi\u1edd cho t\u1edbi khi ch\u1ee9c n\u0103ng th\u1eadn \u0111\u01b0\u1ee3c ki\u1ec3m tra v\u00e0 b\u00ecnh th\u01b0\u1eddng. \u0110i\u1ec1u n\u00e0y nh\u1eb1m gi\u1ea3m nguy c\u01a1 suy th\u1eadn c\u1ea5p v\u00e0 nhi\u1ec5m acid lactic.<\/p>\n<p>N\u00ean ng\u01b0ng metformin v\u00e0o ng\u00e0y ph\u1eabu thu\u1eadt ho\u1eb7c theo h\u01b0\u1edbng d\u1eabn g\u00e2y m\u00ea c\u1ee7a c\u01a1 s\u1edf y t\u1ebf v\u00e0 ch\u1ec9 d\u00f9ng l\u1ea1i sau khi ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng \u1ed5n \u0111\u1ecbnh, th\u01b0\u1eddng \u00edt nh\u1ea5t sau 48 gi\u1edd. N\u1ebfu c\u1ea7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft t\u1ea1m th\u1eddi trong m\u1ed5, chuy\u1ec3n sang insulin.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf CYP2C9 v\u00e0 thu\u1ed1c l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 glibenclamid nh\u01b0 clarithromycin ho\u1eb7c m\u1ed9t s\u1ed1 macrolid v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>D\u00f9ng c\u00f9ng phenylbutazone ho\u1eb7c danazol c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1eb7ng do thay \u0111\u1ed5i k\u1ebft h\u1ee3p g\u1eafn protein ho\u1eb7c chuy\u1ec3n h\u00f3a. U\u1ed1ng r\u01b0\u1ee3u khi d\u00f9ng thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c g\u00e2y ph\u1ea3n \u1ee9ng ki\u1ec3u disulfiram.<\/p>\n<p>Th\u1eadn tr\u1ecdng ho\u1eb7c t\u1ea1m ng\u01b0ng thu\u1ed1c Glucovance 500mg\/2.5 mg khi b\u1ec7nh nh\u00e2n \u0111ang b\u1ecb nhi\u1ec5m tr\u00f9ng n\u1eb7ng, m\u1ea5t n\u01b0\u1edbc, s\u1ed1c, suy h\u00f4 h\u1ea5p ho\u1eb7c suy tim m\u1ea5t b\u00f9 v\u00ec c\u00e1c t\u00ecnh tr\u1ea1ng n\u00e0y l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m acid lactic v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng sulfonylurea \u1edf b\u1ec7nh nh\u00e2n thi\u1ebfu men G6PD v\u00ec c\u00f3 th\u1ec3 kh\u1edfi ph\u00e1t thi\u1ebfu m\u00e1u t\u00e1n huy\u1ebft. Glucovance 500mg\/2.5 mg ch\u1ee9a lactose n\u00ean ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh galactose huy\u1ebft b\u1ea9m sinh ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose. B\u1ec7nh nh\u00e2n th\u1eeba c\u00e2n c\u1ea7n ti\u1ebfp t\u1ee5c \u0103n ki\u1ec1m ch\u1ebf n\u0103ng l\u01b0\u1ee3ng v\u00e0 t\u1eadp luy\u1ec7n theo h\u01b0\u1edbng d\u1eabn.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n tu\u00e2n th\u1ee7 b\u1eefa \u0103n \u0111\u1ec1u \u0111\u1eb7n, t\u1ef1 theo d\u00f5i \u0111\u01b0\u1eddng huy\u1ebft khi c\u00f3 nguy c\u01a1 v\u00e0 trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 n\u1ebfu g\u1eb7p t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n l\u1eb7p l\u1ea1i. \u0110\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3 v\u00e0 xem x\u00e9t thay \u0111\u1ed5i li\u1ec7u ph\u00e1p n\u1ebfu c\u00f3 suy th\u1eadn ti\u1ebfn tri\u1ec3n ho\u1eb7c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1eb7ng t\u00e1i di\u1ec5n.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p : r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, n\u00f4n, bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, ch\u00e1n \u0103n.<\/p>\n<p>\u00cdt g\u1eb7p : t\u0103ng nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh creatinin v\u00e0 ure huy\u1ebft thanh, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin k\u00e8m bi\u1ec3u hi\u1ec7n da.<\/p>\n<p>Hi\u1ebfm g\u1eb7p : gi\u1ea3m natri huy\u1ebft, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, thi\u1ebfu m\u00e1u t\u00e1n huy\u1ebft, b\u1ea5t s\u1ea3n tu\u1ef7 x\u01b0\u01a1ng, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u, ng\u1ee9a, m\u00e0y \u0111ay, ban, vi\u00eam m\u1ea1ch d\u1ecb \u1ee9ng da ho\u1eb7c n\u1ed9i t\u1ea1ng, ban \u0111\u1ecf \u0111a h\u00ecnh, vi\u00eam da tr\u00f3c m\u1ea3nh, nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng, nhi\u1ec5m acid lactic, gi\u1ea3m h\u1ea5p thu vitamin B12 khi d\u00f9ng k\u00e9o d\u00e0i, ph\u1ea3n \u1ee9ng ki\u1ec3u disulfiram khi d\u00f9ng r\u01b0\u1ee3u, b\u1ea5t th\u01b0\u1eddng x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan v\u00e0 vi\u00eam gan.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Kh\u00f4ng d\u00f9ng c\u00f9ng miconazol \u0111\u01b0\u1eddng to\u00e0n th\u00e2n ho\u1eb7c gel b\u00f4i mi\u1ec7ng do c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 glibenclamid v\u00e0 kh\u1edfi ph\u00e1t h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1eb7ng.<\/p>\n<p>D\u00f9ng c\u00f9ng fluconazol ho\u1eb7c c\u00e1c azol \u1ee9c ch\u1ebf CYP2C9 c\u00f3 th\u1ec3 l\u00e0m k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a sulfonylurea do \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a, d\u1eabn t\u1edbi t\u0103ng nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf beta giao c\u1ea3m do nguy c\u01a1 che d\u1ea5u v\u00e0 l\u00e0m n\u1eb7ng tri\u1ec7u ch\u1ee9ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>D\u00f9ng c\u00f9ng r\u01b0\u1ee3u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m acid lactic li\u00ean quan metformin v\u00e0 \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft do sulfonylurea.<\/p>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u, \u0111\u1eb7c bi\u1ec7t l\u00e0 l\u1ee3i ti\u1ec3u quai c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u01b0\u1edbi m\u00e1u th\u1eadn v\u00e0 kh\u1edfi ph\u00e1t suy th\u1eadn l\u00e0m t\u00edch t\u1ee5 metformin d\u1eabn t\u1edbi t\u0103ng nguy c\u01a1 nhi\u1ec5m acid lactic.<\/p>\n<p>D\u00f9ng c\u00f9ng thu\u1ed1c g\u1eafn acid m\u1eadt c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 glibenclamid trong huy\u1ebft t\u01b0\u01a1ng v\u00ec l\u00e0m gi\u1ea3m h\u1ea5p thu, n\u00ean u\u1ed1ng Glucovance 500mg\/2.5 mg \u00edt nh\u1ea5t 4 gi\u1edd tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c g\u1eafn acid m\u1eadt.<\/p>\n<p>Bosentan c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng c\u1ee7a glibenclamid v\u00e0 g\u00e2y gia t\u0103ng men gan khi d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p>Phenylbutazon v\u00e0 danazol c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a sulfonylurea. Th\u1eadn tr\u1ecdng v\u00e0 ki\u1ec3m tra \u0111\u01b0\u1eddng huy\u1ebft ch\u1eb7t ch\u1ebd.<\/p>\n<p>Ch\u1ea5t c\u1ea3n quang ch\u1ee9a iod d\u00f9ng \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch c\u00f3 th\u1ec3 g\u00e2y suy th\u1eadn c\u1ea5p l\u00e0m t\u00edch t\u1ee5 metformin. Ng\u01b0ng Glucovance 500mg\/2.5 mg v\u00e0o th\u1eddi \u0111i\u1ec3m ch\u1ee5p ho\u1eb7c tr\u01b0\u1edbc 48 gi\u1edd t\u00f9y ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 ch\u1ec9 d\u00f9ng l\u1ea1i sau khi ch\u1ee9c n\u0103ng th\u1eadn \u0111\u01b0\u1ee3c ki\u1ec3m tra v\u00e0 tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>Chlorpromazin, corticosteroid v\u00e0 c\u00e1c ch\u1ea5t ch\u1ee7 v\u1eadn beta-2 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u00e0 c\u00e2n nh\u1eafc \u0111i\u1ec1u ch\u1ec9nh li\u1ec7u ph\u00e1p \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng trong th\u1eddi gian d\u00f9ng c\u00e1c thu\u1ed1c n\u00e0y.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 n\u1ebfu \u0111ang d\u1ef1 \u0111\u1ecbnh mang thai ho\u1eb7c c\u00f3 thai. Metformin ho\u1eb7c sulfonylurea kh\u00f4ng ph\u1ea3i l\u1ef1a ch\u1ecdn \u0111\u1ea7u tay cho \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng thai k\u1ef3 v\u00e0 c\u1ea7n \u0111\u00e1nh gi\u00e1 l\u1ee3i \u00edch r\u1ee7i ro theo h\u01b0\u1edbng d\u1eabn chuy\u00ean m\u00f4n. N\u1ebfu ph\u00e1t hi\u1ec7n c\u00f3 thai khi \u0111ang d\u00f9ng Glucovance 500mg\/2.5 mg ph\u1ea3i tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 ngay.<\/p>\n<p>Kh\u00f4ng d\u00f9ng Glucovance 500mg\/2.5 mg n\u1ebfu \u0111ang cho con b\u00fa.<\/p>\n<h3>Kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi d\u00f9ng thu\u1ed1c Glucovance 500mg\/2.5 mg n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Tr\u00e1nh l\u00e1i xe n\u1ebfu c\u00f3 tri\u1ec7u ch\u1ee9ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<h3>Qu\u00e1 li\u1ec1u<\/h3>\n<p>B\u00e1o ngay cho c\u1edf s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n n\u01a1i kh\u00f4 tho\u00e1ng, m\u00e1t, tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng v\u1edbi nh\u01b0:<\/p>\n<ul>\n<li><a href=\"https:\/\/vnras.com\/drug\/metovance\/\">Metovance<\/a> \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp II gi\u00fap ki\u1ec3m so\u00e1t h\u00e0m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng huy\u1ebft. Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh k\u1ebft h\u1ee3p v\u1edbi ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 luy\u1ec7n t\u1eadp th\u1ec3 d\u1ee5c \u0111\u1ec3 gia t\u0103ng s\u1ef1 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft t\u1ed1t h\u01a1n trong su\u1ed1t c\u1ea3 ng\u00e0y.<\/li>\n<li>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/metformin-500mg-tipharco\/\">Metformin 500mg Tipharco<\/a> l\u00e0 thu\u1ed1c thu\u1ed9c nh\u00f3m biguanid, ch\u1ee9a ho\u1ea1t ch\u1ea5t metformin, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, gi\u00fap \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type II<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Kalra, S., Bahendeka, S., Sahay, R., Ghosh, S., Md, F., Orabi, A., Ramaiya, K., Al Shammari, S., Shrestha, D., Shaikh, K., Abhayaratna, S., Shrestha, P. K., Mahalingam, A., Askheta, M., A Rahim, A. A., Eliana, F., Shrestha, H. K., Chaudhary, S., Ngugi, N., Mbanya, J. C., \u2026 Das, A. K. (2018). Consensus Recommendations on Sulfonylurea and Sulfonylurea Combinations in the Management of Type 2 Diabetes Mellitus &#8211; International Task Force. Truy c\u1eadp ng\u00e0y 03\/10\/2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29535952\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29535952\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Glucovance 500mg\/2.5 mg ch\u1ee9a Metformin v\u00e0 Glibenclamid, \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 \u1edf ng\u01b0\u1eddi l\u1edbn khi ch\u1ebf \u0111\u1ed9 \u0103n v\u00e0 t\u1eadp luy\u1ec7n kh\u00f4ng \u0111\u1ee7 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n","protected":false},"author":1,"featured_media":143128,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-143125","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/143125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=143125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/143128"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=143125"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=143125"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=143125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}