{"id":142674,"date":"2025-10-01T15:49:40","date_gmt":"2025-10-01T08:49:40","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=142674"},"modified":"2025-10-01T15:53:36","modified_gmt":"2025-10-01T08:53:36","slug":"tofaxen-5mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tofaxen-5mg\/","title":{"rendered":"Tofaxen 5mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong><a href=\"https:\/\/vnras.com\/drug\/tofaxen-5mg\/\">Tofaxen 5mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Everest Pharmaceuticals.<\/strong><\/p>\n<h2>Tofaxen 5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Tofaxen 5mg <\/strong>c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: <strong>Tofacitinib<\/strong> 5mg (d\u01b0\u1edbi d\u1ea1ng Tofacitinib Citrate).<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: V\u1eeba \u0111\u1ee7 1 vi\u00ean, c\u00f3 th\u1ec3 bao g\u1ed3m Cellulose vi tinh th\u1ec3, Lactose Monohydrate v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c gi\u00fap \u1ed5n \u0111\u1ecbnh vi\u00ean thu\u1ed1c.<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: \u0111ang c\u1eadp nh\u1eadt<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 60 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Bangladesh<\/p>\n<figure id=\"attachment_142691\" aria-describedby=\"caption-attachment-142691\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-142691\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg.jpg\" alt=\"Tofaxen 5mg \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Tofaxen-5mg-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-142691\" class=\"wp-caption-text\">Tofaxen 5mg \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tofaxen 5mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Tofacitinib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf enzyme Janus kinase (JAK). Thu\u1ed1c ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u g\u00e2y vi\u00eam (g\u1ecdi l\u00e0 JAK-STAT) t\u1eeb b\u00ean trong t\u1ebf b\u00e0o.<\/p>\n<p>B\u1eb1ng vi\u1ec7c \u1ee9c ch\u1ebf c\u00e1c enzyme JAK (\u0111\u1eb7c bi\u1ec7t l\u00e0 JAK1 v\u00e0 JAK3), Tofacitinib l\u00e0m gi\u00e1n \u0111o\u1ea1n vi\u1ec7c s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t g\u00e2y vi\u00eam v\u00e0 gi\u00fap \u0111i\u1ec1u h\u00f2a h\u1ec7 mi\u1ec5n d\u1ecbch. K\u1ebft qu\u1ea3 l\u00e0 thu\u1ed1c l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a vi\u00eam m\u1ea1n t\u00ednh nh\u01b0 \u0111au, s\u01b0ng v\u00e0 t\u1ed5n th\u01b0\u01a1ng kh\u1edbp.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Tofacitinib \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh sau khi u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 0.5-1 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 74%. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn s\u1ef1 h\u1ea5p thu.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 40% v\u00e0 ph\u00e2n b\u1ed1 \u0111\u1ec1u gi\u1eefa huy\u1ebft t\u01b0\u01a1ng v\u00e0 c\u00e1c t\u1ebf b\u00e0o m\u00e1u.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Kho\u1ea3ng 70% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a t\u1ea1i gan, ch\u1ee7 y\u1ebfu qua enzyme CYP3A4 v\u00e0 m\u1ed9t ph\u1ea7n nh\u1ecf qua CYP2C19.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Kho\u1ea3ng 30% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c kh\u00e1 ng\u1eafn, kho\u1ea3ng 3 gi\u1edd.<\/p>\n<h2>Thu\u1ed1c Tofaxen 5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (Rheumatoid Arthritis &#8211; RA): D\u00e0nh cho b\u1ec7nh nh\u00e2n c\u00f3 m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng b\u1ec7nh t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng \u0111\u00e3 \u0111\u00e1p \u1ee9ng kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7 ho\u1eb7c kh\u00f4ng dung n\u1ea1p v\u1edbi Methotrexate.<\/p>\n<p>Vi\u00eam kh\u1edbp v\u1ea3y n\u1ebfn (Psoriatic Arthritis &#8211; PsA): D\u00e0nh cho b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u00e1p \u1ee9ng kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7 ho\u1eb7c kh\u00f4ng dung n\u1ea1p v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng th\u1ea5p kh\u1edbp l\u00e0m thay \u0111\u1ed5i b\u1ec7nh (DMARDs).<\/p>\n<p>Vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng (Ulcerative Colitis &#8211; UC): D\u00e0nh cho b\u1ec7nh nh\u00e2n c\u00f3 m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng b\u1ec7nh t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng.<\/p>\n<p>Vi\u00eam c\u1ed9t s\u1ed1ng d\u00ednh kh\u1edbp (Ankylosing Spondylitis &#8211; AS): D\u00e0nh cho b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u00e1p \u1ee9ng kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7 ho\u1eb7c kh\u00f4ng dung n\u1ea1p v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h2>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, Vi\u00eam kh\u1edbp v\u1ea3y n\u1ebfn: 5mg, u\u1ed1ng 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng:<\/p>\n<ul>\n<li>Li\u1ec1u t\u1ea5n c\u00f4ng: 10mg, u\u1ed1ng 2 l\u1ea7n\/ng\u00e0y, trong \u00edt nh\u1ea5t 8 tu\u1ea7n.<\/li>\n<li>Li\u1ec1u duy tr\u00ec: 5mg, u\u1ed1ng 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<\/ul>\n<h3>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Tofaxen 5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u1edbi Tofacitinib ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang c\u00f3 t\u00ecnh tr\u1ea1ng nhi\u1ec5m tr\u00f9ng n\u1eb7ng, \u0111ang ho\u1ea1t \u0111\u1ed9ng, bao g\u1ed3m c\u1ea3 b\u1ec7nh lao.<\/p>\n<p>B\u1ec7nh nh\u00e2n b\u1ecb suy gan n\u1eb7ng.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>T\u0103ng nguy c\u01a1 x\u1ea3y ra c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch l\u1edbn nh\u01b0 nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 \u0111\u1ed9t qu\u1ef5 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: Vi\u00eam m\u0169i h\u1ecdng, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean, \u0111au \u0111\u1ea7u, ti\u00eau ch\u1ea3y, t\u0103ng huy\u1ebft \u00e1p, t\u0103ng ch\u1ec9 s\u1ed1 m\u1ee1 m\u00e1u (cholesterol) v\u00e0 t\u0103ng men gan.<\/p>\n<p>Nghi\u00eam tr\u1ecdng: C\u00e1c nguy c\u01a1 \u0111\u01b0\u1ee3c n\u00eau trong c\u1ea3nh b\u00e1o h\u1ed9p \u0111en, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m h\u1ed3ng c\u1ea7u, th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 v\u00e0 CYP2C19: C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (nh\u01b0 Ketoconazole) ho\u1eb7c k\u1ebft h\u1ee3p \u1ee9c ch\u1ebf CYP3A4 v\u00e0 CYP2C19 (nh\u01b0 Fluconazole) l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Tofacitinib, c\u1ea7n gi\u1ea3m li\u1ec1u Tofaxen.<\/p>\n<p>Thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4: C\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng m\u1ea1nh (nh\u01b0 Rifampicin) l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Tofacitinib, c\u00f3 th\u1ec3 l\u00e0m m\u1ea5t hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 kh\u00f4ng n\u00ean d\u00f9ng chung.<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch kh\u00e1c: Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Tofaxen \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c sinh h\u1ecdc (biologic DMARDs) ho\u1eb7c c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch m\u1ea1nh kh\u00e1c (nh\u01b0 Azathioprine, Cyclosporine).<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh tuy\u1ec7t \u0111\u1ed1i.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c Tofaxen 5mg c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t. N\u1ebfu g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Kinh nghi\u1ec7m v\u1ec1 qu\u00e1 li\u1ec1u Tofacitinib c\u00f2n h\u1ea1n ch\u1ebf. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, c\u1ea7n theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a t\u00e1c d\u1ee5ng ph\u1ee5. \u0110i\u1ec1u tr\u1ecb ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed7 tr\u1ee3. Li\u00ean h\u1ec7 ngay v\u1edbi c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 \u0111\u01b0\u1ee3c x\u1eed tr\u00ed k\u1ecbp th\u1eddi.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c Tofaxen 5mg \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p>\u0110\u1ec3 n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp v\u00e0 \u0111\u1ed9 \u1ea9m cao.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Roy Fleischmann, Joel Kremer. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis, truy c\u1eadp ng\u00e0y 01 th\u00e1ng 10 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22873530\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22873530\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Tofaxen 5mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Everest Pharmaceuticals, ch\u1ee9a Tofacitinib 5mg (d\u01b0\u1edbi d\u1ea1ng Tofacitinib Citrate), ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p.<\/p>\n","protected":false},"author":1,"featured_media":142690,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-142674","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/142674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=142674"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/142690"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=142674"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=142674"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=142674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}