{"id":142362,"date":"2025-09-29T09:15:49","date_gmt":"2025-09-29T02:15:49","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=142362"},"modified":"2025-09-29T09:16:57","modified_gmt":"2025-09-29T02:16:57","slug":"prograf-0-5mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/prograf-0-5mg\/","title":{"rendered":"Prograf 0.5mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong><a href=\"https:\/\/vnras.com\/drug\/?post_type=product&amp;p=142362&amp;preview=true\">Prograf 0.5mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Astellas Ireland Co.,Ltd., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-14708-12.<\/strong><\/p>\n<h2>Prograf 0.5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Prograf 0.5mg<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: <strong>Tacrolimus 0.5mg<\/strong> (d\u01b0\u1edbi d\u1ea1ng tacrolimus khan).<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Lactose, hydroxypropyl methylcellulose, croscarmellose natri, magnesi stearat, gelatin, titan dioxid, v\u00e0 oxid s\u1eaft v\u00e0ng.<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-14708-12<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: C\u1ed9ng h\u00f2a Ireland<\/p>\n<figure id=\"attachment_142370\" aria-describedby=\"caption-attachment-142370\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-142370\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6.jpg\" alt=\"Prograf 0.5mg ph\u00f2ng ng\u1ee9a s\u1ef1 \u0111\u00e0o th\u1ea3i c\u01a1 quan gh\u00e9p t\u1ea1ng\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Prograf-0.5mg-6-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-142370\" class=\"wp-caption-text\">Prograf 0.5mg ph\u00f2ng ng\u1ee9a s\u1ef1 \u0111\u00e0o th\u1ea3i c\u01a1 quan gh\u00e9p t\u1ea1ng<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Prograf 0.5mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Tacrolimus \u1ee9c ch\u1ebf h\u1ec7 mi\u1ec5n d\u1ecbch b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 ho\u1ea1t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o T-lympho. C\u01a1 ch\u1ebf n\u00e0y ho\u1ea1t \u0111\u1ed9ng nh\u01b0 sau:<\/p>\n<ul>\n<li>T\u1ea1o ph\u1ee9c h\u1ee3p: Sau khi v\u00e0o t\u1ebf b\u00e0o, Tacrolimus g\u1eafn v\u1edbi protein n\u1ed9i b\u00e0o FKBP-12.<\/li>\n<li>\u1ee8c ch\u1ebf Calcineurin: Ph\u1ee9c h\u1ee3p Tacrolimus-FKBP-12 n\u00e0y sau \u0111\u00f3 s\u1ebd v\u00f4 hi\u1ec7u h\u00f3a enzyme calcineurin.<\/li>\n<li>Ch\u1eb7n t\u00edn hi\u1ec7u: Vi\u1ec7c n\u00e0y ng\u0103n ch\u1eb7n calcineurin k\u00edch ho\u1ea1t y\u1ebfu t\u1ed1 NF-AT, m\u1ed9t t\u00edn hi\u1ec7u c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111i v\u00e0o nh\u00e2n t\u1ebf b\u00e0o.<\/li>\n<li>Ng\u1eebng s\u1ea3n xu\u1ea5t IL-2: Khi kh\u00f4ng c\u00f3 t\u00edn hi\u1ec7u t\u1eeb NF-AT, t\u1ebf b\u00e0o T kh\u00f4ng s\u1ea3n xu\u1ea5t \u0111\u01b0\u1ee3c Interleukin-2 (IL-2), m\u1ed9t cytokine quan tr\u1ecdng cho vi\u1ec7c t\u0103ng sinh v\u00e0 ho\u1ea1t h\u00f3a c\u1ee7a ch\u00ednh n\u00f3.<\/li>\n<\/ul>\n<p>K\u1ebft qu\u1ea3 cu\u1ed1i c\u00f9ng l\u00e0 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o T b\u1ecb suy gi\u1ea3m m\u1ea1nh m\u1ebd, t\u1eeb \u0111\u00f3 ng\u0103n ch\u1eb7n \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh th\u1ea3i gh\u00e9p c\u1ea5p.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Thu\u1ed1c h\u1ea5p thu k\u00e9m v\u00e0 kh\u00f4ng \u1ed5n \u0111\u1ecbnh qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1eb7c bi\u1ec7t b\u1ecb gi\u1ea3m m\u1ea1nh khi d\u00f9ng chung v\u1edbi th\u1ee9c \u0103n gi\u00e0u ch\u1ea5t b\u00e9o.<\/p>\n<p>Ph\u00e2n b\u1ed1: Tacrolimus li\u00ean k\u1ebft r\u1ea5t m\u1ea1nh v\u1edbi h\u1ed3ng c\u1ea7u, do \u0111\u00f3 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c ph\u1ea3i \u0111\u01b0\u1ee3c theo d\u00f5i trong m\u00e1u to\u00e0n ph\u1ea7n.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n \u1edf gan v\u00e0 ru\u1ed9t b\u1edfi enzyme CYP3A4, l\u00e0 nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y ra nhi\u1ec1u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c.<\/p>\n<p>Th\u1ea3i tr\u1eeb: C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua ph\u00e2n.<\/p>\n<h2>Thu\u1ed1c Prograf 0.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Prograf \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 d\u1ef1 ph\u00f2ng s\u1ef1 \u0111\u00e0o th\u1ea3i c\u01a1 quan gh\u00e9p \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em nh\u1eadn gh\u00e9p gan, th\u1eadn ho\u1eb7c tim d\u1ecb sinh (gh\u00e9p t\u1eeb ng\u01b0\u1eddi hi\u1ebfn kh\u00e1c lo\u00e0i). Thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch kh\u00e1c nh\u01b0 corticosteroid.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h2>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c t\u00ednh d\u1ef1a tr\u00ean lo\u1ea1i t\u1ea1ng gh\u00e9p, c\u00e2n n\u1eb7ng c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 ph\u00e1c \u0111\u1ed3 c\u1ee7a t\u1eebng trung t\u00e2m gh\u00e9p. Tuy nhi\u00ean, li\u1ec1u duy tr\u00ec s\u1ebd \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh li\u00ean t\u1ee5c d\u1ef1a tr\u00ean k\u1ebft qu\u1ea3 theo d\u00f5i n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y c\u1ee7a tacrolimus trong m\u00e1u to\u00e0n ph\u1ea7n, k\u1ebft h\u1ee3p v\u1edbi \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng v\u1ec1 ch\u1ee9c n\u0103ng c\u01a1 quan gh\u00e9p v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u tham kh\u1ea3o cho ng\u01b0\u1eddi l\u1edbn:<\/p>\n<ul>\n<li>Gh\u00e9p th\u1eadn: 0,2 mg\/kg\/ng\u00e0y, chia l\u00e0m 2 l\u1ea7n.<\/li>\n<li>Gh\u00e9p gan: 0,10 &#8211; 0,15 mg\/kg\/ng\u00e0y, chia l\u00e0m 2 l\u1ea7n.<\/li>\n<\/ul>\n<h3>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>U\u1ed1ng thu\u1ed1c 2 l\u1ea7n m\u1ed7i ng\u00e0y, c\u00e1ch nhau 12 gi\u1edd (v\u00ed d\u1ee5: 8 gi\u1edd s\u00e1ng v\u00e0 8 gi\u1edd t\u1ed1i).<\/p>\n<p>N\u00ean u\u1ed1ng thu\u1ed1c m\u1ed9t c\u00e1ch th\u1ed1ng nh\u1ea5t, ho\u1eb7c lu\u00f4n c\u00f9ng v\u1edbi th\u1ee9c \u0103n ho\u1eb7c lu\u00f4n l\u00fac \u0111\u00f3i \u0111\u1ec3 gi\u1ea3m s\u1ef1 bi\u1ebfn thi\u00ean trong h\u1ea5p thu. U\u1ed1ng l\u00fac \u0111\u00f3i (1 gi\u1edd tr\u01b0\u1edbc ho\u1eb7c 2-3 gi\u1edd sau \u0103n) gi\u00fap thu\u1ed1c h\u1ea5p thu t\u1ed1t nh\u1ea5t.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Prograf 0.5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng Prograf \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi Tacrolimus ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Prograf c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh ho\u1eb7c m\u1ea1n t\u00ednh, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng li\u1ec1u cao. C\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn (creatinin huy\u1ebft thanh) th\u01b0\u1eddng xuy\u00ean.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t (t\u1ef7 l\u1ec7 \u226530% \u1edf b\u1ec7nh nh\u00e2n gh\u00e9p th\u1eadn) bao g\u1ed3m: nhi\u1ec5m tr\u00f9ng, run, t\u0103ng huy\u1ebft \u00e1p, ch\u1ee9c n\u0103ng th\u1eadn b\u1ea5t th\u01b0\u1eddng, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111au \u0111\u1ea7u, \u0111au b\u1ee5ng, m\u1ea5t ng\u1ee7, bu\u1ed3n n\u00f4n, gi\u1ea3m magnesi huy\u1ebft, v\u00e0 thi\u1ebfu m\u00e1u.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Do chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua CYP3A4, Prograf c\u00f3 r\u1ea5t nhi\u1ec1u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c quan tr\u1ecdng:<\/p>\n<ul>\n<li>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 (l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a Prograf): Kh\u00e1ng sinh nh\u00f3m macrolid (clarithromycin, erythromycin), thu\u1ed1c kh\u00e1ng n\u1ea5m nh\u00f3m azole (ketoconazole, itraconazole, voriconazole), thu\u1ed1c \u1ee9c ch\u1ebf protease (ritonavir), thu\u1ed1c ch\u1eb9n k\u00eanh canxi (diltiazem, verapamil), v\u00e0 n\u01b0\u1edbc b\u01b0\u1edfi.<\/li>\n<li>C\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 (l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Prograf, t\u0103ng nguy c\u01a1 th\u1ea3i gh\u00e9p): Thu\u1ed1c ch\u1ed1ng co gi\u1eadt (carbamazepine, phenytoin), kh\u00e1ng sinh (rifampin), v\u00e0 th\u1ea3o d\u01b0\u1ee3c St. John&#8217;s Wort. B\u1ec7nh nh\u00e2n ph\u1ea3i th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c (k\u1ec3 c\u1ea3 thu\u1ed1c kh\u00f4ng k\u00ea \u0111\u01a1n v\u00e0 th\u1ea3o d\u01b0\u1ee3c) \u0111ang s\u1eed d\u1ee5ng.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: Tacrolimus \u0111i qua nhau thai. Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c trong thai k\u1ef3 c\u00f3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 t\u0103ng kali huy\u1ebft v\u00e0 suy th\u1eadn \u1edf tr\u1ebb s\u01a1 sinh. Ch\u1ec9 s\u1eed d\u1ee5ng khi l\u1ee3i \u00edch cho m\u1eb9 v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1 cho thai nhi.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Tacrolimus \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. Ph\u1ee5 n\u1eef \u0111ang d\u00f9ng Prograf kh\u00f4ng n\u00ean cho con b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Prograf c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c v\u00e0 th\u1ea7n kinh. N\u1ebfu g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 bao g\u1ed3m c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e3 n\u00eau nh\u01b0ng \u1edf m\u1ee9c \u0111\u1ed9 n\u1eb7ng h\u01a1n. X\u1eed tr\u00ed ch\u1ee7 y\u1ebfu l\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 chung. Tacrolimus kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u do li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein v\u00e0 h\u1ed3ng c\u1ea7u.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, kh\u00f4ng qu\u00e1 30\u00b0C, \u1edf n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Prograf 0.5mg<\/h2>\n<p>Tr\u00ean th\u1ecb tr\u01b0\u1eddng c\u00f3 c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u0169ng ch\u1ee9a ho\u1ea1t ch\u1ea5t Tacrolimus 0.5mg, v\u00ed d\u1ee5 nh\u01b0 thu\u1ed1c<a href=\"https:\/\/vnras.com\/drug\/ckdtacrobell-0-5mg\/\"> CKDTacroBell 0.5mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Chong Kun Dang Pharmaceutical Corp. Vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i gi\u1eefa c\u00e1c bi\u1ec7t d\u01b0\u1ee3c ch\u1ee9a Tacrolimus ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa gh\u00e9p t\u1ea1ng do s\u1ef1 kh\u00e1c bi\u1ec7t nh\u1ecf v\u1ec1 sinh kh\u1ea3 d\u1ee5ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>Christine E Staatz, Susan E Tett. Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation, truy c\u1eadp ng\u00e0y 29 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15244495\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15244495\/<\/a><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Prograf 0.5mg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i file <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Huong-dan-su-dung-Prograf-0.5mg.pdf\">t\u1ea1i \u0111\u00e2y<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Prograf 0.5mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Astellas Ireland Co.,Ltd., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-14708-12, ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng s\u1ef1 \u0111\u00e0o th\u1ea3i c\u01a1 quan gh\u00e9p.<\/p>\n","protected":false},"author":1,"featured_media":142367,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-142362","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/142362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=142362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/142367"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=142362"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=142362"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=142362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}