{"id":141783,"date":"2025-09-27T23:14:56","date_gmt":"2025-09-27T16:14:56","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=141783"},"modified":"2025-09-27T23:16:21","modified_gmt":"2025-09-27T16:16:21","slug":"haxium-40-dhg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/haxium-40-dhg\/","title":{"rendered":"Haxium 40 DHG"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Haxium 40 DHG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110269523 (S\u0110K c\u0169: VD-30250-18)<\/strong><\/p>\n<h2>Haxium 40 DHG l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Haxium 40 DHG<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Esomeprazol (d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t bao tan trong ru\u1ed9t ch\u1ee9a esomeprazol magnesium trihydrat) \u2026\u2026\u2026&#8230;&#8230;&#8230;40mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Polysorbat 80, titan dioxyd, talc, natri hydroxyd, sugar spheres, natri carbonat, acid methacrylic L30 D, HPMC, triethyl citrat.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u1ee9ng ch\u1ee9a vi h\u1ea1t bao tan trong ru\u1ed9t<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110269523 (S\u0110K c\u0169: VD-30250-18)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 24 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Haxium 40 DHG<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Esomeprazol l\u00e0 \u0111\u1ed3ng ph\u00e2n quang h\u1ecdc d\u1ea1ng S c\u1ee7a omeprazol, c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc ho\u1ea1t \u0111\u1ed9ng c\u1ee7a b\u01a1m proton t\u1ea1i t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y.<\/p>\n<p>Khi \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o c\u01a1 th\u1ec3, thu\u1ed1c nhanh ch\u00f3ng t\u1eadp trung t\u1ea1i c\u00e1c ti\u1ec3u qu\u1ea3n ch\u1ebf ti\u1ebft \u2013 n\u01a1i c\u00f3 \u0111\u1ed9 acid cao. T\u1ea1i \u0111\u00e2y, esomeprazol \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i sang d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n<p>D\u1ea1ng ho\u1ea1t h\u00f3a n\u00e0y s\u1ebd g\u1eafn k\u1ebft kh\u00f4ng h\u1ed3i ph\u1ee5c v\u1edbi enzym H\u207a\/K\u207a-ATPase, l\u00e0m gi\u00e1n \u0111o\u1ea1n qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ion v\u00e0 t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 b\u00e0i ti\u1ebft acid d\u1ecbch v\u1ecb.<\/p>\n<p>Nh\u1edd c\u01a1 ch\u1ebf n\u00e0y, thu\u1ed1c gi\u00fap ki\u1ec3m so\u00e1t c\u1ea3 t\u00ecnh tr\u1ea1ng ti\u1ebft acid c\u01a1 b\u1ea3n v\u00e0 acid t\u0103ng ti\u1ebft khi b\u1ecb k\u00edch th\u00edch b\u1edfi c\u00e1c y\u1ebfu t\u1ed1 kh\u00e1c nhau.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Esomeprazol c\u00f3 t\u1ed1c \u0111\u1ed9 h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 th\u1eddi gian \u0111\u1ec3 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong m\u00e1u nh\u00ecn chung dao \u0111\u1ed9ng trong v\u00f2ng 1\u20132 gi\u1edd.<\/p>\n<p>Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a esomeprazol ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng v\u00e0 c\u00f3 xu h\u01b0\u1edbng t\u0103ng khi d\u00f9ng nhi\u1ec1u l\u1ea7n: kho\u1ea3ng 68% v\u1edbi li\u1ec1u 20 mg v\u00e0 c\u00f3 th\u1ec3 l\u00ean t\u1edbi g\u1ea7n 89% v\u1edbi li\u1ec1u 40 mg.<\/p>\n<p>M\u1ee9c \u0111\u1ed9 h\u1ea5p thu ho\u1ea1t ch\u1ea5t esomeprazol c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm v\u00e0 l\u00e0m gi\u1ea3m khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi th\u1ee9c \u0103n. N\u1ebfu u\u1ed1ng c\u00f9ng b\u1eefa \u0103n, di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) gi\u1ea3m kho\u1ea3ng 43\u201353%. V\u00ec v\u1eady, khuy\u1ebfn c\u00e1o n\u00ean d\u00f9ng thu\u1ed1c khi b\u1ee5ng r\u1ed7ng, t\u1ed1t nh\u1ea5t l\u00e0 u\u1ed1ng tr\u01b0\u1edbc b\u1eefa \u0103n \u00edt nh\u1ea5t 1 gi\u1edd.<\/p>\n<p>Kho\u1ea3ng 97% esomeprazol g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 albumin.<\/p>\n<p>Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u1ee7a thu\u1ed1c di\u1ec5n ra ch\u1ee7 y\u1ebfu t\u1ea1i gan, trong \u0111\u00f3 enzym CYP2C19 \u0111\u1ea3m nh\u1eadn vai tr\u00f2 ch\u00ednh, bi\u1ebfn \u0111\u1ed5i thu\u1ed1c th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a m\u1ea5t ho\u1ea1t t\u00ednh; \u0111\u1ed3ng th\u1eddi, m\u1ed9t ph\u1ea7n nh\u1ecf \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua CYP3A4 t\u1ea1o th\u00e0nh esomeprazol sulfon.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a esomeprazol trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 1,3 gi\u1edd, tuy nhi\u00ean t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf acid k\u00e9o d\u00e0i h\u01a1n do s\u1ef1 g\u1eafn k\u1ebft b\u1ec1n v\u1eefng v\u1edbi b\u01a1m proton.<\/p>\n<p>Ph\u1ea7n l\u1edbn esomeprazol sau khi v\u00e0o c\u01a1 th\u1ec3 s\u1ebd \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf qua th\u1eadn, chi\u1ebfm kho\u1ea3ng 4\/5 li\u1ec1u d\u00f9ng, ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng \u0111\u00e3 chuy\u1ec3n h\u00f3a; l\u01b0\u1ee3ng c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c \u0111\u01b0a ra ngo\u00e0i qua ph\u00e2n.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng, kh\u1ea3 n\u0103ng th\u1ea3i tr\u1eeb gi\u1ea3m \u0111\u00e1ng k\u1ec3 khi\u1ebfn AUC c\u1ee7a esomeprazol c\u00f3 th\u1ec3 t\u0103ng g\u1ea5p 2\u20133 l\u1ea7n so v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng, do \u0111\u00f3 c\u1ea7n c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 t\u00edch l\u0169y v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<h2>Thu\u1ed1c Haxium 40 DHG \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng.<\/p>\n<p>Ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb lo\u00e9t li\u00ean quan \u0111\u1ebfn thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid.<\/p>\n<p>Ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb lo\u00e9t do stress.<\/p>\n<p>Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y \u2013 th\u1ef1c qu\u1ea3n.<\/p>\n<p>Xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a do lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng n\u1eb7ng sau can thi\u1ec7p n\u1ed9i soi nh\u1eb1m ph\u00f2ng t\u00e1i xu\u1ea5t huy\u1ebft.<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger \u2013 Ellison.<\/p>\n<figure id=\"attachment_141800\" aria-describedby=\"caption-attachment-141800\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-141800\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG.jpg\" alt=\"Haxium 40 DHG\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Haxium-40-DHG-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-141800\" class=\"wp-caption-text\">Thu\u1ed1c Haxium 40 DHG c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y &#8211; t\u00e1 tr\u00e0ng<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><em><strong>Ng\u01b0\u1eddi l\u1edbn<\/strong><\/em><\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng c\u00f3 H. pylori: 1 vi\u00ean Haxium 40 \u00d7 1 l\u1ea7n\/ng\u00e0y trong 10 ng\u00e0y.<\/p>\n<p>Lo\u00e9t do NSAID ho\u1eb7c lo\u00e9t do stress: 20mg esomeprazol m\u1ed7i ng\u00e0y trong 4 \u2013 8 tu\u1ea7n (n\u00ean \u0111\u1ed5i d\u1ea1ng b\u00e0o ch\u1ebf c\u00f3 h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p)<\/p>\n<p>Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y \u2013 th\u1ef1c qu\u1ea3n c\u00f3 vi\u00eam tr\u1ee3t: 1 vi\u00ean Haxium 40 m\u1ed7i ng\u00e0y trong 4 tu\u1ea7n, c\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u00eam 4 tu\u1ea7n; t\u1ed1i \u0111a 8 tu\u1ea7n n\u1ebfu v\u1ebft t\u1ed5n th\u01b0\u01a1ng ch\u01b0a l\u00e0nh<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb duy tr\u00ec sau khi li\u1ec1n s\u1eb9o ho\u1eb7c \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng kh\u00f4ng vi\u00eam tr\u1ee3t: 20mg esomeprazol m\u1ed7i ng\u00e0y (n\u00ean \u0111\u1ed5i d\u1ea1ng b\u00e0o ch\u1ebf c\u00f3 h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p)<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger \u2013 Ellison: kh\u1edfi \u0111\u1ea7u 40 mg \u00d7 2 l\u1ea7n\/ng\u00e0y; c\u00f3 th\u1ec3 t\u0103ng 80 mg 1 \u2013 2 l\u1ea7n\/ng\u00e0y, t\u1ed1i \u0111a 120 mg \u00d7 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p><em><strong>Tr\u1ebb em:<\/strong><\/em> do li\u1ec1u l\u01b0\u1ee3ng d\u00f9ng th\u1ea5p h\u01a1n 1 vi\u00ean Haxium 40 n\u00ean \u0111\u1ed5i d\u1ea1ng b\u00e0o ch\u1ebf c\u00f3 h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p<\/p>\n<p><em><strong>B\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t<\/strong><\/em><\/p>\n<p>Suy gan nh\u1eb9 \u2013 trung b\u00ecnh\/suy th\u1eadn\/cao tu\u1ed5i: kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Suy gan n\u1eb7ng: t\u1ed1i \u0111a 20mg esomeprazol m\u1ed7i ng\u00e0y (n\u00ean \u0111\u1ed5i d\u1ea1ng b\u00e0o ch\u1ebf c\u00f3 h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p_<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>U\u1ed1ng nguy\u00ean <strong>vi\u00ean nang Haxium 40 DHG<\/strong> v\u1edbi n\u01b0\u1edbc, \u00edt nh\u1ea5t 1 gi\u1edd tr\u01b0\u1edbc b\u1eefa \u0103n. C\u00f3 th\u1ec3 k\u1ebft h\u1ee3p thu\u1ed1c kh\u00e1ng acid khi c\u1ea7n \u0111\u1ec3 gi\u1ea3m tri\u1ec7u ch\u1ee9ng \u0111au.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Haxium 40 DHG trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi qu\u00e1 m\u1eabn v\u1edbi esomeprazol, c\u00e1c d\u1eabn ch\u1ea5t benzimidazol ho\u1eb7c b\u1ea5t c\u1ee9 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Haxium 40 DHG<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng nelfinavir.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, n\u1ebfu b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n nh\u1eefng d\u1ea5u hi\u1ec7u c\u1ea3nh b\u00e1o nghi ng\u1edd b\u1ec7nh l\u00fd n\u1eb7ng nh\u01b0: gi\u1ea3m c\u00e2n nhanh kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n, n\u00f4n t\u00e1i ph\u00e1t nhi\u1ec1u l\u1ea7n, kh\u00f3 nu\u1ed1t, n\u00f4n ra m\u00e1u ho\u1eb7c \u0111i ngo\u00e0i ph\u00e2n \u0111en, c\u1ea7n \u0111\u01b0\u1ee3c th\u0103m kh\u00e1m v\u00e0 lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng ung th\u01b0 d\u1ea1 d\u00e0y, v\u00ec vi\u1ec7c d\u00f9ng esomeprazol c\u00f3 th\u1ec3 che gi\u1ea5u tri\u1ec7u ch\u1ee9ng v\u00e0 tr\u00ec ho\u00e3n ch\u1ea9n \u0111o\u00e1n.<\/p>\n<p>V\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p ph\u1ea3i \u0111i\u1ec1u tr\u1ecb trong th\u1eddi gian d\u00e0i, \u0111\u1eb7c bi\u1ec7t tr\u00ean 12 th\u00e1ng, ng\u01b0\u1eddi b\u1ec7nh n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i \u0111\u1ecbnh k\u1ef3 nh\u1eb1m ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n ho\u1eb7c bi\u1ebfn ch\u1ee9ng li\u00ean quan.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u1eb9 nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111i\u1ec3n h\u00ecnh l\u00e0 nhi\u1ec5m Salmonella v\u00e0 Campylobacter, do s\u1ef1 gi\u1ea3m \u0111\u1ed9 acid d\u1ea1 d\u00e0y t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho vi sinh v\u1eadt ph\u00e1t tri\u1ec3n.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Ph\u1ea3n \u1ee9ng th\u01b0\u1eddng g\u1eb7p: \u0110au \u0111\u1ea7u, c\u1ea3m gi\u00e1c ch\u00f3ng m\u1eb7t; r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n, \u0111\u1ea7y b\u1ee5ng, t\u00e1o b\u00f3n ho\u1eb7c ti\u00eau ch\u1ea3y; mi\u1ec7ng kh\u00f4; c\u00f3 th\u1ec3 n\u1ed5i ban \u0111\u1ecf ngo\u00e0i da.<\/p>\n<p>Ph\u1ea3n \u1ee9ng \u00edt g\u1eb7p: B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb m\u1ec7t m\u1ecfi, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 (m\u1ea5t ng\u1ee7 ho\u1eb7c bu\u1ed3n ng\u1ee7), d\u1ecb c\u1ea3m, ng\u1ee9a, ph\u00e1t ban; m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u00f3 r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c tho\u00e1ng qua.<\/p>\n<p>Ph\u1ea3n \u1ee9ng hi\u1ebfm g\u1eb7p: Xu\u1ea5t hi\u1ec7n s\u1ed1t, \u0111\u1ed5 m\u1ed3 h\u00f4i nhi\u1ec1u, ph\u00f9 ngo\u1ea1i bi\u00ean, nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng, r\u1ee5ng t\u00f3c; c\u00f3 th\u1ec3 x\u1ea3y ra ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng n\u1eb7ng nh\u01b0 m\u00e0y \u0111ay, ph\u00f9 m\u1ea1ch, co th\u1eaft ph\u1ebf qu\u1ea3n ho\u1eb7c s\u1ed1c ph\u1ea3n v\u1ec7.<\/p>\n<p>Ngo\u00e0i ra, c\u00f3 ghi nh\u1eadn r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n (k\u00edch \u0111\u1ed9ng, tr\u1ea7m c\u1ea3m, l\u00fa l\u1eabn, \u1ea3o gi\u00e1c), nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, thay \u0111\u1ed5i huy\u1ebft h\u1ecdc (gi\u1ea3m b\u1ea1ch c\u1ea7u, ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u), t\u1ed5n th\u01b0\u01a1ng gan (t\u0103ng men gan, vi\u00eam gan, suy gan), r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, vi\u00eam mi\u1ec7ng, h\u1ea1 magie m\u00e1u ho\u1eb7c natri m\u00e1u, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin, \u0111au kh\u1edbp \u2013 \u0111au c\u01a1, lo\u00e3ng x\u01b0\u01a1ng v\u00e0 g\u00e3y x\u01b0\u01a1ng, vi\u00eam th\u1eadn k\u1ebd, ch\u1ee9ng to v\u00fa \u1edf nam, c\u00f9ng c\u00e1c ph\u1ea3n \u1ee9ng da n\u1eb7ng nh\u01b0 h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson,<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Esomeprazol l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 acid trong d\u1ea1 d\u00e0y, t\u1eeb \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c ph\u1ee5 thu\u1ed9c pH nh\u01b0: ketoconazol, itraconazol, erlotinib, mu\u1ed1i s\u1eaft, digoxin.<\/p>\n<p>Thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf enzym CYP2C19 \u2013 m\u1ed9t trong nh\u1eefng enzym chuy\u1ec3n h\u00f3a ch\u00ednh \u2013 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u00e1c thu\u1ed1c d\u00f9ng chung nh\u01b0 diazepam, citalopram, imipramin, clomipramin, phenytoin. Khi ph\u1ed1i h\u1ee3p c\u1ea7n theo d\u00f5i v\u00e0 c\u00f3 th\u1ec3 ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Esomeprazol c\u0169ng b\u1ecb chuy\u1ec3n h\u00f3a qua CYP2C19 v\u00e0 CYP3A4. Khi ph\u1ed1i h\u1ee3p v\u1edbi clarithromycin (ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh), di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a esomeprazol c\u00f3 th\u1ec3 t\u0103ng g\u1ea5p \u0111\u00f4i. N\u1ebfu d\u00f9ng chung v\u1edbi c\u00e1c thu\u1ed1c v\u1eeba \u1ee9c ch\u1ebf CYP2C19 v\u1eeba \u1ee9c ch\u1ebf CYP3A4, n\u1ed3ng \u0111\u1ed9 v\u00e0 th\u1eddi gian ti\u1ebfp x\u00fac v\u1edbi esomeprazol c\u00f3 th\u1ec3 t\u0103ng h\u01a1n hai l\u1ea7n, l\u00e0m t\u0103ng nguy c\u01a1 g\u1eb7p t\u00e1c d\u1ee5ng ph\u1ee5, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi suy gan n\u1eb7ng ho\u1eb7c \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Hi\u1ec7n ch\u01b0a ghi nh\u1eadn b\u1eb1ng ch\u1ee9ng cho th\u1ea5y esomeprazol g\u00e2y h\u1ea1i tr\u1ef1c ti\u1ebfp \u0111\u1ebfn thai nhi ho\u1eb7c tr\u1ebb b\u00fa m\u1eb9. Tuy nhi\u00ean, v\u00ec d\u1eef li\u1ec7u l\u00e2m s\u00e0ng c\u00f2n h\u1ea1n ch\u1ebf, vi\u1ec7c s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai c\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb v\u00e0 nguy c\u01a1 ti\u1ec1m \u1ea9n.<\/p>\n<p>V\u1edbi ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa, thu\u1ed1c c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 \u1edf m\u1ee9c \u0111\u1ed9 th\u1ea5p. Do \u0111\u00f3, c\u1ea7n tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc khi d\u00f9ng, v\u00e0 ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng t\u1eadp trung.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang v\u1eadn h\u00e0nh m\u00e1y m\u00f3c n\u1eb7ng, \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n giao th\u00f4ng ho\u1eb7c l\u00e0m vi\u1ec7c tr\u00ean cao n\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c, v\u00e0 c\u1ea7n ng\u1eebng ho\u1ea1t \u0111\u1ed9ng nguy hi\u1ec3m n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Bi\u1ec3u hi\u1ec7n qu\u00e1 li\u1ec1u: Hi\u1ec7n ch\u01b0a c\u00f3 nhi\u1ec1u kinh nghi\u1ec7m v\u1ec1 vi\u1ec7c d\u00f9ng qu\u00e1 li\u1ec1u esomeprazol. M\u1ed9t s\u1ed1 b\u00e1o c\u00e1o cho th\u1ea5y li\u1ec1u u\u1ed1ng 280 mg c\u00f3 th\u1ec3 g\u00e2y ra t\u00ecnh tr\u1ea1ng m\u1ec7t m\u1ecfi v\u00e0 r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, trong khi li\u1ec1u \u0111\u01a1n 80 mg \u0111\u01b0\u1eddng u\u1ed1ng v\u1eabn \u0111\u01b0\u1ee3c dung n\u1ea1p m\u00e0 kh\u00f4ng xu\u1ea5t hi\u1ec7n bi\u1ebfn c\u1ed1 nghi\u00eam tr\u1ecdng.<\/p>\n<p>C\u00e1ch x\u1eed tr\u00ed: Ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho esomeprazol. Do thu\u1ed1c g\u1eafn m\u1ea1nh v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng n\u00ean l\u1ecdc m\u00e1u kh\u00f4ng hi\u1ec7u qu\u1ea3. Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ch\u1ee7 y\u1ebfu l\u00e0 x\u1eed tr\u00ed tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 to\u00e0n tr\u1ea1ng cho ng\u01b0\u1eddi b\u1ec7nh, \u0111\u1ea3m b\u1ea3o c\u00e1c ch\u1ee9c n\u0103ng s\u1ed1ng cho \u0111\u1ebfn khi thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i ra ngo\u00e0i.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Haxium 40 DHG \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Haxium 40 DHG trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Haxium 40 DHG khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p><span style=\"font-size: 14.4px;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Haxium 40 DHG nh\u01b0:<\/span><\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/savi-esomeprazole-40\/\">SaVi Esomeprazole 40<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Esomeprazole v\u1edbi h\u00e0m l\u01b0\u1ee3ng 40mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m SaVi, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y &#8211; t\u00e1 tr\u00e0ng<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/esomaxcare-40\/\">Esomaxcare 40<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Esomeprazole v\u1edbi h\u00e0m l\u01b0\u1ee3ng 40mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Square Pharmaceuticals Ltd, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y &#8211; t\u00e1 tr\u00e0ng<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Haxium 40 DHG \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/To-huong-dan-su-dung-Haxium-40-DHG-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 27 th\u00e1ng 9 n\u0103m 2025<\/li>\n<li>Hou M, Hu H, Jin C, Yu X (2020). Efficacy and Safety of Esomeprazole for the Treatment of Reflux Symptoms in Patients with Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis. Iran J Public Health. Truy c\u1eadp ng\u00e0y 27 th\u00e1ng 9 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8215048\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8215048\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Haxium 40 DHG thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf b\u01a1m proton \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y &#8211; t\u00e1 tr\u00e0ng, tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft acid b\u1ec7nh l\u00fd kh\u00e1c.<\/p>\n","protected":false},"author":1,"featured_media":141784,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-141783","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/141783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=141783"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/141784"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=141783"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=141783"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=141783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}