{"id":141416,"date":"2025-10-01T15:44:46","date_gmt":"2025-10-01T08:44:46","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=141416"},"modified":"2025-10-01T15:46:39","modified_gmt":"2025-10-01T08:46:39","slug":"kipel-4","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/kipel-4\/","title":{"rendered":"Kipel 4"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <\/strong><a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/kipel-4\/\">Kipel 4<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi MSN Laboratories Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-11965-11.<\/strong><\/p>\n<h2>Kipel 4 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Thu\u1ed1c Kipel 4<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n: Montelukast 4mg<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nhai<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-11965-11<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 24 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Kipel 4<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Montelukast thu\u1ed9c nh\u00f3m thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 leukotriene.<\/p>\n<p>C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng: Montelukast \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc v\u00e0 c\u00f3 \u00e1i l\u1ef1c cao v\u1edbi th\u1ee5 th\u1ec3 cysteinyl leukotriene 1 (CysLT1), h\u1ea1n ch\u1ebf qu\u00e1 tr\u00ecnh gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam m\u1ea1ch, \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng trong b\u1ec7nh hen v\u00e0 vi\u00eam m\u0169i d\u1ecb \u1ee9ng: co th\u1eaft ph\u1ebf qu\u1ea3n, kh\u00f3 th\u1edf, t\u0103ng ti\u1ebft ch\u1ea5t nh\u1ea7y, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, ph\u00f9 n\u1ec1 v\u00e0 vi\u00eam \u0111\u01b0\u1eddng th\u1edf.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Montelukast h\u1ea5p thu nhanh ch\u00f3ng khi s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u0111\u1ea1t \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 3 gi\u1edd, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 64%. S\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a th\u1ee9c \u0103n kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ph\u00e2n b\u1ed1: T\u1ef7 l\u1ec7 Montelukast li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 99%, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh kho\u1ea3ng 8-11L<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Montelukast \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i, t\u1ea1o th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Montelukast \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua ph\u00e2n, v\u00e0 m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<h2>Thu\u1ed1c Kipel 4 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c <strong>Kipel 4<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng cho tr\u1ebb em 2 \u0111\u1ebfn 14 tu\u1ed5i:<\/p>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng hen ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m v\u00e0 vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a<\/li>\n<\/ul>\n<figure id=\"attachment_142676\" aria-describedby=\"caption-attachment-142676\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-142676\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4.jpg\" alt=\"Thu\u1ed1c Kipel 4 \u0111i\u1ec1u tr\u1ecb hen suy\u1ec5n m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 trung b\u00ecnh\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/10\/Kipel-4-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-142676\" class=\"wp-caption-text\">Thu\u1ed1c Kipel 4 \u0111i\u1ec1u tr\u1ecb hen suy\u1ec5n m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 trung b\u00ecnh<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Kipel 4<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"2\" width=\"158\">Ch\u1ec9 \u0111\u1ecbnh<\/td>\n<td colspan=\"3\" width=\"466\">Li\u1ec1u d\u00f9ng<\/td>\n<\/tr>\n<tr>\n<td width=\"159\">Tr\u1ebb em &lt; 2 tu\u1ed5i<\/td>\n<td width=\"157\">Tr\u1ebb em 2-5 tu\u1ed5i<\/td>\n<td width=\"150\">Tr\u1ebb em 6-14 tu\u1ed5i<\/td>\n<\/tr>\n<tr>\n<td width=\"158\">Hen ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh<\/td>\n<td width=\"159\">Tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129<\/td>\n<td width=\"157\">4 mg\/ng\u00e0y<\/td>\n<td width=\"150\">5 mg\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td width=\"158\">Vi\u00eam m\u0169i d\u1ecb \u1ee9ng<\/td>\n<td width=\"159\">D\u1eef li\u1ec7u an to\u00e0n ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp<\/td>\n<td width=\"157\">4 mg\/ng\u00e0y<\/td>\n<td width=\"150\">5 mg\/ng\u00e0y<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p>Thu\u1ed1c Kipel 4 d\u1ea1ng vi\u00ean nhai, b\u1ec7nh nh\u00e2n c\u1ea7n nhai k\u1ef9 v\u00e0 u\u1ed1ng c\u00f9ng n\u01b0\u1edbc.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Kipel 4 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng Kipel 4 cho ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi Montelukast ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o trong thu\u1ed1c.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Kipel 4<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Kipel 4 trong \u0111i\u1ec1u tr\u1ecb co th\u1eaft ph\u1ebf qu\u1ea3n trong c\u01a1n hen c\u1ea5p t\u00ednh.<\/li>\n<li>Kh\u00f4ng \u0111\u1ed9t ng\u1ed9t thay th\u1ebf corticoid b\u1eb1ng montelukast<\/li>\n<li>Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n m\u1eabn c\u1ea3m v\u1edbi aspirin v\u00e0 thu\u1ed1c NSAID<\/li>\n<li>Tri\u1ec7u ch\u1ee9ng r\u1ed1i lo\u1ea1n th\u1ea7n kinh t\u00e2m th\u1ea7n (k\u00edch \u0111\u1ed9ng, \u1ea3o gi\u00e1c, m\u1ea5t ng\u1ee7, m\u1ed9ng du,\u2026) \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi \u0111i\u1ec1u tr\u1ecb v\u1edbi Kipel 4. C\u00e2n nh\u1eafc l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 khi xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean.<\/li>\n<li>C\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u corticoid d\u00f9ng c\u00f9ng Kipel 4 khi xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng vi\u00eam m\u1ea1ch<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi d\u00f9ng Kipel 4: \u0111au \u0111\u1ea7u, \u0111au b\u1ee5ng, ho, c\u1ea3m c\u00fam, kh\u00f3 ti\u00eau, t\u0103ng men gan, suy nh\u01b0\u1ee3c c\u01a1 th\u1ec3, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi , s\u1ed1t, ng\u1ea1t m\u0169i, d\u1ecb \u1ee9ng, ph\u00e1t ban, \u0111ua r\u0103ng, vi\u00eam d\u1ea1 d\u00e0y ru\u1ed9t,\u2026<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Hi\u1ec7n nay ch\u01b0a ghi nh\u1eadn t\u01b0\u01a1ng t\u00e1c b\u1ea5t l\u1ee3i khi d\u00f9ng Kipel 4 v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c. M\u1ed9t s\u1ed1 c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u thu\u1ed1c khi u\u1ed1ng c\u00f9ng prednison, theophylin, thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng, NSAID, thu\u1ed1c ng\u1ee7, wafarin, hormon tuy\u1ebfn gi\u00e1p,\u2026<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng Kipel 4 cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c Kipel 4 c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, m\u1ec7t m\u1ecfi, ch\u00f3ng m\u1eb7t, \u1ea3o gi\u00e1c, m\u1ea5t ng\u1ee7, th\u1eadn tr\u1ecdng khi d\u00f9ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>S\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u Kipel 4 g\u00e2y \u0111au \u0111\u1ea7u, n\u00f4n, bu\u1ed3n ng\u1ee7, \u0111au b\u1ee5ng, k\u00edch \u0111\u1ed9ng. Hi\u1ec7n ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho montelukast.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Khuy\u1ebfn kh\u00edch b\u1ea3o qu\u1ea3n Kipel 4 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30 \u0111\u1ed9 C, kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi \u00e1nh s\u00e1ng c\u01b0\u1eddng \u0111\u1ed9 cao. N\u00ean \u0111\u1ec3 s\u1ea3n ph\u1ea9m c\u00e1ch xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Kipel 4 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/hiskast-4mg\/\">Hiskast 4mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n montelukast 4mg, s\u1ea3n xu\u1ea5t b\u1edfi C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C PH\u1ea8M 3\/2, ki\u1ec3m so\u00e1t hen ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/elumast-4mg\/\">Elumast 4mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n montelukast 4mg, s\u1ea3n xu\u1ea5t b\u1edfi Laboratorios Cinfa, S.A, \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng hen ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh, vi\u00eam m\u0169i d\u1ecb \u1ee9ng<\/p>\n<h2>Thu\u1ed1c Kipel 4 c\u00f3 ph\u1ea3i kh\u00e1ng sinh kh\u00f4ng?<\/h2>\n<p>Kh\u00f4ng, thu\u1ed1c Kipel 4 kh\u00f4ng thu\u1ed9c nh\u00f3m thu\u1ed1c kh\u00e1ng sinh, kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n, k\u00ecm khu\u1ea9n.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>Van Hecken A, Depr\u00e9 M, Verbesselt R, Wynants K, De Lepeleire I, Arnout J, Wong PH, Freeman A, Holland S, Gertz B, De Schepper PJ. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10234597\/\" rel=\"noopener\">Effect of montelukast on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers<\/a>, truy c\u1eadp ng\u00e0y 01 th\u00e1ng 10 n\u0103m 2025<\/li>\n<li>Goel K, Singh D, Goyal R, Bansal S, Singh S, Sharma N, Gupta S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40715741\/\" rel=\"noopener\">New insights on pharmacological potential of montelukast: a comprehensive review<\/a>, truy c\u1eadp ng\u00e0y 01 th\u00e1ng 10 n\u0103m 2025<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Kipel 4 \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng hen ph\u1ebf qu\u1ea3n m\u1ea1n t\u00ednh, gi\u1ea3m tri\u1ec7u ch\u1ee9ng vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m v\u00e0 vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a, s\u1ea3n xu\u1ea5t b\u1edfi MSN Laboratories Limited<\/p>\n","protected":false},"author":1,"featured_media":142677,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-141416","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/141416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=141416"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/142677"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=141416"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=141416"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=141416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}