{"id":140578,"date":"2025-09-22T15:16:27","date_gmt":"2025-09-22T08:16:27","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=140578"},"modified":"2025-09-22T15:18:01","modified_gmt":"2025-09-22T08:18:01","slug":"spiromide-40","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/spiromide-40\/","title":{"rendered":"Spiromide 40"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong><a href=\"https:\/\/vnras.com\/drug\/spiromide-40\/\">Spiromide 40<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi The Searle Company Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 896110796824 (VN-16905-13).<\/strong><\/p>\n<h2>Spiromide 40 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Spiromide 40<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c l\u1ee3i ti\u1ec3u ph\u1ed1i h\u1ee3p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng theo \u0111\u01a1n, m\u1ed7i vi\u00ean n\u00e9n bao phim ch\u1ee9a <strong>Furosemide 40 mg <\/strong>v\u00e0 Spironolactone 50 mg.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 896110796824 (VN-16905-13)<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Pakistan<\/p>\n<figure id=\"attachment_140583\" aria-describedby=\"caption-attachment-140583\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-140583\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40.jpg\" alt=\"Spiromide 40 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u01b0\u1eddng Aldosterone nguy\u00ean ph\u00e1t\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Spiromide-40-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-140583\" class=\"wp-caption-text\">Spiromide 40 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u01b0\u1eddng Aldosterone nguy\u00ean ph\u00e1t<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Spiromide 40<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Spiromide 40 ho\u1ea1t \u0111\u1ed9ng d\u1ef1a tr\u00ean c\u01a1 ch\u1ebf hi\u1ec7p \u0111\u1ed3ng c\u1ee7a hai th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Furosemide: L\u00e0 l\u1ee3i ti\u1ec3u quai m\u1ea1nh, \u1ee9c ch\u1ebf s\u1ef1 t\u00e1i h\u1ea5p thu Natri, Kali v\u00e0 Clo \u1edf nh\u00e1nh l\u00ean c\u1ee7a quai Henle. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn t\u0103ng th\u1ea3i tr\u1eeb n\u01b0\u1edbc v\u00e0 c\u00e1c ch\u1ea5t \u0111i\u1ec7n gi\u1ea3i, g\u00e2y ra t\u00e1c d\u1ee5ng l\u1ee3i ti\u1ec3u m\u1ea1nh v\u00e0 nhanh ch\u00f3ng.<\/li>\n<li>Spironolactone: L\u00e0 l\u1ee3i ti\u1ec3u gi\u1eef kali, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u0111\u1ed1i kh\u00e1ng c\u1ea1nh tranh v\u1edbi hormone Aldosterone \u1edf \u1ed1ng l\u01b0\u1ee3n xa. C\u01a1 ch\u1ebf n\u00e0y gi\u00fap t\u0103ng th\u1ea3i tr\u1eeb natri v\u00e0 n\u01b0\u1edbc, \u0111\u1ed3ng th\u1eddi gi\u1eef l\u1ea1i kali, qua \u0111\u00f3 ch\u1ed1ng l\u1ea1i t\u00e1c d\u1ee5ng g\u00e2y m\u1ea5t kali c\u1ee7a Furosemide.<\/li>\n<\/ul>\n<p>S\u1ef1 k\u1ebft h\u1ee3p n\u00e0y v\u1eeba mang l\u1ea1i hi\u1ec7u qu\u1ea3 l\u1ee3i ti\u1ec3u m\u1ea1nh m\u1ebd, v\u1eeba gi\u00fap duy tr\u00ec s\u1ef1 \u1ed5n \u0111\u1ecbnh \u0111i\u1ec7n gi\u1ea3i t\u1ed1t h\u01a1n so v\u1edbi d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u \u0111\u01a1n thu\u1ea7n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Spironolactone h\u1ea5p thu t\u1ed1t h\u01a1n khi d\u00f9ng c\u00f9ng b\u1eefa \u0103n do t\u0103ng \u0111\u1ed9 h\u00f2a tan v\u00e0 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh r\u1ed7ng c\u1ee7a d\u1ea1 d\u00e0y. Ng\u01b0\u1ee3c l\u1ea1i, th\u1ee9c \u0103n l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Furosemide kho\u1ea3ng 30%. Do \u0111\u00f3, vi\u1ec7c d\u00f9ng thu\u1ed1c c\u00f9ng v\u1edbi th\u1ee9c \u0103n \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a s\u1ef1 h\u1ea5p thu c\u1ee7a Spironolactone.<\/p>\n<p>Ph\u00e2n b\u1ed1: C\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (Spironolactone kho\u1ea3ng 98%, Furosemide ch\u1ee7 y\u1ebfu v\u1edbi albumin).<\/p>\n<p>Chuy\u1ec3n h\u00f3a v\u00e0 Th\u1ea3i tr\u1eeb: Spironolactone \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh \u1edf gan. Furosemide \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. C\u1ea3 hai thu\u1ed1c \u0111\u1ec1u qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o nhau thai v\u00e0 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<h2>Thu\u1ed1c Spiromide 40 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb ph\u00f9 do c\u01b0\u1eddng Aldosterone th\u1ee9 ph\u00e1t (trong suy tim sung huy\u1ebft, x\u01a1 gan c\u1ed5 tr\u01b0\u1edbng).<\/p>\n<p>Ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p ph\u00f9 kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi nh\u1eefng li\u1ec7u ph\u00e1p l\u1ee3i ti\u1ec3u kh\u00e1c \u0111\u00e3 d\u00f9ng.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u01b0\u1eddng Aldosterone nguy\u00ean ph\u00e1t.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h2>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>Li\u1ec1u l\u01b0\u1ee3ng ph\u1ea3i do b\u00e1c s\u0129 ch\u1ec9 \u0111\u1ecbnh d\u1ef1a tr\u00ean t\u00ecnh tr\u1ea1ng b\u1ec7nh. Li\u1ec1u th\u00f4ng th\u01b0\u1eddng cho ng\u01b0\u1eddi l\u1edbn c\u00f3 th\u1ec3 t\u1eeb 1 \u0111\u1ebfn 4 vi\u00ean m\u1ed7i ng\u00e0y.<\/p>\n<h3>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c<\/h3>\n<p>N\u00ean u\u1ed1ng thu\u1ed1c c\u00f9ng v\u1edbi b\u1eefa \u0103n v\u00e0o bu\u1ed5i s\u00e1ng \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a h\u1ea5p thu v\u00e0 tr\u00e1nh g\u00e2y ti\u1ec3u \u0111\u00eam.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Spiromide 40 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi Furosemide, Spironolactone, c\u00e1c thu\u1ed1c nh\u00f3m sulfonamide ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>T\u0103ng kali m\u00e1u (Hyperkalemia).<\/p>\n<p>H\u1ea1 natri m\u00e1u n\u1eb7ng.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng ho\u1eb7c v\u00f4 ni\u1ec7u (kh\u00f4ng s\u1ea3n xu\u1ea5t \u0111\u01b0\u1ee3c n\u01b0\u1edbc ti\u1ec3u).<\/p>\n<p>B\u1ec7nh Addison.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Nguy c\u01a1 t\u0103ng kali m\u00e1u (Hyperkalemia) l\u00e0 c\u1ea3nh b\u00e1o quan tr\u1ecdng nh\u1ea5t, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c c\u0169ng l\u00e0m t\u0103ng kali (thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, ch\u1eb9n th\u1ee5 th\u1ec3 Angiotensin II, NSAIDs).<\/p>\n<p>C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd \u0111i\u1ec7n gi\u1ea3i \u0111\u1ed3 (Kali, Natri) v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn (Creatinin) \u0111\u1ecbnh k\u1ef3 trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Li\u00ean quan \u0111\u1ebfn Spironolactone: T\u0103ng kali m\u00e1u , ch\u1ee9ng v\u00fa to \u1edf nam gi\u1edbi , r\u1ed1i lo\u1ea1n kinh nguy\u1ec7t.<\/p>\n<p>Li\u00ean quan \u0111\u1ebfn Furosemide: R\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i (h\u1ea1 kali, natri) , t\u0103ng acid uric, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft , \u0111\u1ed9c t\u00ednh tr\u00ean tai (\u1edf li\u1ec1u cao).<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>C\u00e1c thu\u1ed1c l\u00e0m t\u0103ng kali m\u00e1u (ACEi, ARB, NSAIDs, ch\u1ebf ph\u1ea9m b\u1ed5 sung kali) khi d\u00f9ng chung s\u1ebd l\u00e0m t\u0103ng nguy c\u01a1 t\u0103ng kali m\u00e1u nghi\u00eam tr\u1ecdng.<\/p>\n<p>Digoxin: Spironolactone l\u00e0m gi\u1ea3m th\u1ea3i tr\u1eeb Digoxin, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a Digoxin.<\/p>\n<p>Lithium: Thu\u1ed1c l\u1ee3i ti\u1ec3u l\u00e0m gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a Lithium, t\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c.<\/p>\n<p>Thu\u1ed1c h\u1ea1 \u00e1p kh\u00e1c: T\u0103ng nguy c\u01a1 h\u1ea1 huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh do thu\u1ed1c qua \u0111\u01b0\u1ee3c nhau thai v\u00e0 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Kh\u00f4ng c\u00f3 th\u00f4ng tin c\u1ee5 th\u1ec3, nh\u01b0ng c\u1ea7n th\u1eadn tr\u1ecdng v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u Spiromide 40 c\u00f3 th\u1ec3 g\u00e2y m\u1ea5t n\u01b0\u1edbc v\u00e0 \u0111i\u1ec7n gi\u1ea3i n\u1eb7ng. Vi\u1ec7c x\u1eed tr\u00ed bao g\u1ed3m ng\u01b0ng thu\u1ed1c, b\u00f9 d\u1ecbch v\u00e0 \u0111i\u1ec7n gi\u1ea3i d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t y t\u1ebf.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n Spiromide 40 \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C, tr\u00e1nh \u1ea9m v\u00e0 \u00e1nh s\u00e1ng.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Spiromide 40<\/h2>\n<p><a href=\"https:\/\/www.vnras.com\/drug\/spiromide\">Spiromide 40<\/a>, s\u1ea3n xu\u1ea5t b\u1edfi Searle Pakistan Limited , l\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u ph\u1ed1i h\u1ee3p Spironolactone 50mg v\u00e0 Furosemide 40mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng ph\u00f9 v\u00e0 cao huy\u1ebft \u00e1p.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Ivan Velat, \u017deljko Bu\u0161i\u0107. Furosemide and spironolactone doses and hyponatremia in patients with heart failure, truy c\u1eadp ng\u00e0y 21 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32746925\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32746925\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Spiromide 40 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi The Searle Company Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 896110796824 (VN-16905-13), \u0111i\u1ec1u tr\u1ecb ph\u00f9 do c\u01b0\u1eddng Aldosterone th\u1ee9 ph\u00e1t.<\/p>\n","protected":false},"author":1,"featured_media":140582,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-140578","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/140578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=140578"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/140582"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=140578"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=140578"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=140578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}