{"id":140490,"date":"2025-09-22T14:07:15","date_gmt":"2025-09-22T07:07:15","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=140490"},"modified":"2025-09-22T14:13:43","modified_gmt":"2025-09-22T07:13:43","slug":"babytrim-new","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/babytrim-new\/","title":{"rendered":"Babytrim-New"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Babytrim-New \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m Trung \u01b0\u01a1ng I &#8211; Pharbaco c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110209625 (S\u0110K c\u0169: VD-27075-17)<\/strong><\/p>\n<h2>Babytrim-New l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i g\u00f3i <strong>b\u1ed9t Babytrim-New<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Sulfamethoxazol:&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..200mg<\/li>\n<li>Trimethoprim:&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.40mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Lactose, \u0111\u01b0\u1eddng k\u00ednh, aspartam, tinh d\u1ea7u cam v\u1eeba \u0111\u1ee7 1,5g.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: B\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110209625 (S\u0110K c\u0169: VD-27075-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 g\u00f3i x 1,5g<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Babytrim-New<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Sulfamethoxazol: thu\u1ed9c nh\u00f3m sulfonamid, ho\u1ea1t \u0111\u1ed9ng kh\u00e1ng khu\u1ea9n v\u1edbi c\u01a1 ch\u1ebf c\u1ea1nh tranh v\u1edbi para-aminobenzoic acid, t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh acid folic c\u1ee7a vi khu\u1ea9n.<\/p>\n<p>Trimethoprim: ho\u1ea1t \u0111\u1ed9ng kh\u00e1ng khu\u1ea9n nh\u1edd \u1ee9c ch\u1ebf enzym dihydrofolat reductase, ng\u0103n c\u1ea3n s\u1ef1 kh\u1eed dihydrofolat th\u00e0nh tetrahydrofolat.<\/p>\n<p>S\u1ef1 ph\u1ed1i h\u1ee3p n\u00e0y \u1ee9c ch\u1ebf li\u00ean ti\u1ebfp hai b\u01b0\u1edbc trong con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a acid folic, l\u00e0m vi khu\u1ea9n m\u1ea5t kh\u1ea3 n\u0103ng t\u1ed5ng h\u1ee3p purin, thymidin v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 DNA. Nh\u1edd \u0111\u00f3, thu\u1ed1c ph\u00e1t huy hi\u1ec7u qu\u1ea3 di\u1ec7t khu\u1ea9n m\u1ea1nh, k\u1ec3 c\u1ea3 v\u1edbi nh\u1eefng ch\u1ee7ng \u0111\u00e3 kh\u00e1ng ri\u00eang l\u1ebb m\u1ed9t trong hai ho\u1ea1t ch\u1ea5t.<\/p>\n<p>Babytrim-New c\u00f3 ph\u1ed5 t\u00e1c d\u1ee5ng r\u1ed9ng, hi\u1ec7u qu\u1ea3 tr\u00ean nhi\u1ec1u lo\u1ea1i vi khu\u1ea9n Gram d\u01b0\u01a1ng, Gram \u00e2m, n\u1ea5m v\u00e0 k\u00fd sinh tr\u00f9ng nh\u01b0: <em>E.coli, Klebsiella, Enterobacter, Streptococcus pneumoniae, Shigella, Haemophilus influenzae, Proteus, Pneumocystis carinii (jiroveci)\u2026<\/em><\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: C\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft thanh \u0111\u1ea1t sau 1\u20134 gi\u1edd. Trimethoprim c\u00f3 n\u1ed3ng \u0111\u1ed9 1\u20132 mcg\/ml, c\u00f2n sulfamethoxazol \u0111\u1ea1t 40\u201360 mcg\/ml \u1edf d\u1ea1ng t\u1ef1 do. Khi d\u00f9ng nhi\u1ec1u li\u1ec1u, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u \u1ed5n \u0111\u1ecbnh th\u01b0\u1eddng cao h\u01a1n kho\u1ea3ng 50% so v\u1edbi m\u1ed9t li\u1ec1u \u0111\u01a1n.<\/p>\n<p>Ph\u00e2n b\u1ed1: Ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0o m\u00f4 v\u00e0 d\u1ecbch c\u01a1 th\u1ec3, k\u1ec3 c\u1ea3 d\u1ecbch n\u00e3o t\u1ee7y. Trimethoprim c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 100\u2013120 l\u00edt, l\u1edbn h\u01a1n sulfamethoxazol (12\u201318 l\u00edt). Kho\u1ea3ng 44% trimethoprim v\u00e0 70% sulfamethoxazol g\u1eafn protein huy\u1ebft t\u01b0\u01a1ng. Thu\u1ed1c qua nhau thai, v\u00e0o n\u01b0\u1edbc \u1ed1i v\u00e0 c\u00f3 trong s\u1eefa m\u1eb9.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: C\u1ea3 trimethoprim v\u00e0 sulfamethoxazol \u0111\u1ec1u tr\u1ea3i qua qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a t\u1ea1i gan tr\u01b0\u1edbc khi \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i ra ngo\u00e0i.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a trimethoprim dao \u0111\u1ed9ng t\u1eeb 8\u201311 gi\u1edd, trong khi \u0111\u00f3 sulfamethoxazol c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i d\u00e0i h\u01a1n, kho\u1ea3ng 10\u201313 gi\u1edd. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, hai th\u00f4ng s\u1ed1 n\u00e0y c\u00f3 th\u1ec3 k\u00e9o d\u00e0i h\u01a1n, khi\u1ebfn thu\u1ed1c t\u00edch l\u0169y trong c\u01a1 th\u1ec3. Trong v\u00f2ng 24 gi\u1edd sau khi d\u00f9ng, c\u00f3 kho\u1ea3ng 50\u201360% li\u1ec1u trimethoprim v\u00e0 45\u201370% li\u1ec1u sulfamethoxazol \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u, ph\u1ea7n l\u1edbn d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c c\u00f2n gi\u1eef nguy\u00ean ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/p>\n<h2>Thu\u1ed1c Babytrim-New \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra, bao g\u1ed3m:<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a: ti\u00eau ch\u1ea3y do E.coli, l\u1ef5 tr\u1ef1c khu\u1ea9n Shigella, h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb th\u01b0\u01a1ng h\u00e0n, ph\u00f3 th\u01b0\u01a1ng h\u00e0n.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean v\u00e0 d\u01b0\u1edbi: vi\u00eam h\u1ecdng, vi\u00eam tai gi\u1eefa, vi\u00eam ph\u1ed5i, \u0111\u1ee3t c\u1ea5p vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n, vi\u00eam ph\u1ed5i do Pneumocystis jiroveci.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u d\u01b0\u1edbi kh\u00f4ng bi\u1ebfn ch\u1ee9ng, vi\u00eam tuy\u1ebfn ti\u1ec1n li\u1ec7t.<\/p>\n<p>C\u00e1c b\u1ec7nh kh\u00e1c: brucella, d\u1ecbch h\u1ea1ch, toxoplasmosis.<\/p>\n<figure id=\"attachment_140561\" aria-describedby=\"caption-attachment-140561\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-140561\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New.jpg\" alt=\"Babytrim-New\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Babytrim-New-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-140561\" class=\"wp-caption-text\">Thu\u1ed1c Babytrim-New c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><em><strong>Li\u1ec1u \u0111\u01b0\u1ee3c t\u00ednh theo trimethoprim trong ph\u1ed1i h\u1ee3p.<\/strong><\/em><\/p>\n<p>Vi\u00eam tai gi\u1eefa c\u1ea5p: 8mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, d\u00f9ng 10 ng\u00e0y.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng ti\u1ebft ni\u1ec7u kh\u00f4ng bi\u1ebfn ch\u1ee9ng: 8mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, d\u00f9ng 3\u201310 ng\u00e0y.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng ti\u1ebft ni\u1ec7u m\u1ea1n t\u00ednh ho\u1eb7c t\u00e1i ph\u00e1t: 8mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, d\u00f9ng 10\u201314 ng\u00e0y.<\/p>\n<p>\u0110\u1ee3t c\u1ea5p vi\u00eam ph\u1ebf qu\u1ea3n m\u1ea1n: 8mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, trong 10 ng\u00e0y.<\/p>\n<p>L\u1ef5 tr\u1ef1c khu\u1ea9n: 8mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, trong 5 ng\u00e0y.<\/p>\n<p>Brucella: 10mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, trong 4\u20136 tu\u1ea7n.<\/p>\n<p>T\u1ea3: 4\u20135mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, trong 3 ng\u00e0y, k\u1ebft h\u1ee3p b\u00f9 d\u1ecbch v\u00e0 \u0111i\u1ec7n gi\u1ea3i.<\/p>\n<p>D\u1ecbch h\u1ea1ch (d\u1ef1 ph\u00f2ng sau ph\u01a1i nhi\u1ec5m): 8 mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, trong 7 ng\u00e0y.<\/p>\n<p>Vi\u00eam ph\u1ed5i do Pneumocystis jiroveci: 15\u201320 mg trimethoprim tr\u00ean kg c\u00e2n n\u1eb7ng m\u1ed7i\u00a0 ng\u00e0y, chia 3\u20134 l\u1ea7n, trong 14\u201321 ng\u00e0y.<\/p>\n<p>D\u1ef1 ph\u00f2ng Pneumocystis ho\u1eb7c toxoplasma \u1edf tr\u1ebb nhi\u1ec5m HIV: 150mg trimethoprim m\u1ed7i ng\u00e0y, chia 2 l\u1ea7n, d\u00f9ng 3 ng\u00e0y li\u00ean ti\u1ebfp m\u1ed7i tu\u1ea7n.<\/p>\n<p><em><strong>\u0110i\u1ec1u ch\u1ec9nh \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn (\u226512 tu\u1ed5i)<\/strong><\/em><\/p>\n<ul>\n<li>\u0110\u1ed9 thanh th\u1ea3i creatinin &gt;30 ml\/ph\u00fat: d\u00f9ng li\u1ec1u th\u00f4ng th\u01b0\u1eddng.<\/li>\n<li>15\u201330 ml\/ph\u00fat: d\u00f9ng \u00bd li\u1ec1u.<\/li>\n<li>&lt;15 ml\/ph\u00fat: kh\u00f4ng d\u00f9ng.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>X\u00e9 g\u00f3i <strong>thu\u1ed1c Babytrim-New<\/strong> theo \u0111\u01b0\u1eddng k\u1ebb, \u0111\u1ed5 b\u1ed9t v\u00e0o c\u1ed1c, th\u00eam l\u01b0\u1ee3ng n\u01b0\u1edbc v\u1eeba \u0111\u1ee7 v\u00e0 khu\u1ea5y \u0111\u1ec1u. U\u1ed1ng ngay sau khi pha.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Babytrim-New trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Tr\u1ebb d\u01b0\u1edbi 2 th\u00e1ng tu\u1ed5i ho\u1eb7c tr\u1ebb sinh non.<\/p>\n<p>Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi sulfamethoxazol, trimethoprim ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng m\u00e0 kh\u00f4ng th\u1ec3 theo d\u00f5i n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh gan n\u1eb7ng, t\u1ed5n th\u01b0\u01a1ng nhu m\u00f4 gan ho\u1eb7c r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng hi\u1ebfm g\u1eb7p c\u00f3 th\u1ec3 x\u1ea3y ra nh\u01b0: ho\u1ea1i t\u1eed gan c\u1ea5p, gi\u1ea3m b\u1ea1ch c\u1ea7u, thi\u1ebfu m\u00e1u b\u1ea5t s\u1ea3n, h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson (SJS), ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN).<\/p>\n<p>N\u1ebfu xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u ph\u00e1t ban, ph\u1ed3ng r\u1ed9p ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c, ph\u1ea3i ng\u01b0ng thu\u1ed1c ngay.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i d\u1ec5 g\u1eb7p t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n, \u0111\u1eb7c bi\u1ec7t n\u1ebfu c\u00f3 suy th\u1eadn, suy gan ho\u1eb7c d\u00f9ng \u0111\u1ed3ng th\u1eddi nhi\u1ec1u thu\u1ed1c kh\u00e1c.<\/p>\n<p>C\u1ea7n theo d\u00f5i c\u00f4ng th\u1ee9c m\u00e1u \u0111\u1ecbnh k\u1ef3 n\u1ebfu d\u00f9ng k\u00e9o d\u00e0i, nh\u1ea5t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n thi\u1ebfu folat. C\u00f3 th\u1ec3 b\u1ed5 sung acid folic \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 thi\u1ebfu m\u00e1u.<\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y tan m\u00e1u \u1edf ng\u01b0\u1eddi thi\u1ebfu men G6PD.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n d\u1ecb \u1ee9ng n\u1eb7ng, hen ph\u1ebf qu\u1ea3n.<\/p>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng trong vi\u00eam h\u1ecdng do li\u00ean c\u1ea7u nh\u00f3m A v\u00ec k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n penicillin.<\/p>\n<p>Trimethoprim c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng chuy\u1ec3n h\u00f3a phenylalanin, c\u1ea7n l\u01b0u \u00fd \u1edf b\u1ec7nh nh\u00e2n phenylketon ni\u1ec7u.<\/p>\n<p>Tr\u00e1nh d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin.<\/p>\n<p>Theo d\u00f5i kali huy\u1ebft khi d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 t\u0103ng kali.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p><em><strong>Th\u01b0\u1eddng g\u1eb7p (ADR &gt; 1\/100)<\/strong><\/em><\/p>\n<p>To\u00e0n th\u00e2n: M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb s\u1ed1t trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n<p>Ti\u00eau h\u00f3a: C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u1ea3m gi\u00e1c bu\u1ed3n n\u00f4n, n\u00f4n \u00f3i, ti\u00eau ch\u1ea3y ho\u1eb7c vi\u00eam l\u01b0\u1ee1i g\u00e2y kh\u00f3 ch\u1ecbu khi \u0103n u\u1ed1ng.<\/p>\n<p>Da li\u1ec5u: Xu\u1ea5t hi\u1ec7n ng\u1ee9a ng\u00e1y, n\u1ed5i m\u1ea9n \u0111\u1ecf ho\u1eb7c ph\u00e1t ban ngo\u00e0i da.<\/p>\n<p><em><strong>\u00cdt g\u1eb7p (1\/1000 &lt; ADR &lt; 1\/100)<\/strong><\/em><\/p>\n<p>Huy\u1ebft h\u1ecdc: C\u00f3 th\u1ec3 x\u1ea3y ra t\u00ecnh tr\u1ea1ng t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, ho\u1eb7c xu\u1ea5t hi\u1ec7n c\u00e1c m\u1ea3ng xu\u1ea5t huy\u1ebft d\u01b0\u1edbi da.<\/p>\n<p>Da: M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p ghi nh\u1eadn ph\u00e1t ban d\u1ea1ng m\u00e0y \u0111ay.<\/p>\n<p><em><strong>Hi\u1ebfm g\u1eb7p (ADR &lt; 1\/1000)<\/strong><\/em><\/p>\n<p>To\u00e0n th\u00e2n: C\u00f3 th\u1ec3 x\u1ea3y ra ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 nghi\u00eam tr\u1ecdng ho\u1eb7c b\u1ec7nh huy\u1ebft thanh.<\/p>\n<p>M\u00e1u: Ghi nh\u1eadn c\u00e1c r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc nh\u01b0 thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3, thi\u1ebfu m\u00e1u t\u00e1n huy\u1ebft, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t v\u00e0 th\u1eadm ch\u00ed l\u00e0 gi\u1ea3m to\u00e0n b\u1ed9 t\u1ebf b\u00e0o m\u00e1u.<\/p>\n<p>Th\u1ea7n kinh: M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p xu\u1ea5t hi\u1ec7n vi\u00eam m\u00e0ng n\u00e3o v\u00f4 khu\u1ea9n.<\/p>\n<p>Da: G\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng n\u1eb7ng nh\u01b0 h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (h\u1ed9i ch\u1ee9ng Lyell), ban \u0111\u1ecf \u0111a d\u1ea1ng, ph\u00f9 m\u1ea1ch, ho\u1eb7c t\u00ecnh tr\u1ea1ng nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng.<\/p>\n<p>Gan: C\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn v\u00e0ng da, \u1ee9 m\u1eadt, ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng ho\u1ea1i t\u1eed t\u1ebf b\u00e0o gan.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Ghi nh\u1eadn t\u00ecnh tr\u1ea1ng t\u0103ng kali m\u00e1u ho\u1eb7c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>T\u00e2m th\u1ea7n: M\u1ed9t s\u1ed1 \u00edt b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n \u1ea3o gi\u00e1c.<\/p>\n<p>Ti\u1ebft ni\u1ec7u \u2013 sinh d\u1ee5c: C\u00f3 th\u1ec3 g\u00e2y suy th\u1eadn, vi\u00eam th\u1eadn k\u1ebd ho\u1eb7c h\u00ecnh th\u00e0nh s\u1ecfi th\u1eadn.<\/p>\n<p>Tai: C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng \u00f9 tai.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Trimethoprim c\u00f3 th\u1ec3 l\u00e0m sai l\u1ec7ch k\u1ebft qu\u1ea3 \u0111o n\u1ed3ng \u0111\u1ed9 creatinin huy\u1ebft t\u01b0\u01a1ng khi d\u00f9ng ph\u1ea3n \u1ee9ng picrat ki\u1ec1m.<\/p>\n<p>Khi ph\u1ed1i h\u1ee3p v\u1edbi zidovudin, nguy c\u01a1 r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc t\u0103ng l\u00ean; c\u1ea7n theo d\u00f5i huy\u1ebft h\u1ecdc th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi cyclosporin \u1edf b\u1ec7nh nh\u00e2n gh\u00e9p th\u1eadn c\u00f3 th\u1ec3 g\u00e2y suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn h\u1ed3i ph\u1ee5c.<\/p>\n<p>Rifampicin l\u00e0m r\u00fat ng\u1eafn th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a trimethoprim sau kho\u1ea3ng 1 tu\u1ea7n d\u00f9ng chung, nh\u01b0ng \u00edt \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p>Trimethoprim c\u1ea1nh tranh th\u1ea3i tr\u1eeb \u1edf th\u1eadn v\u1edbi procainamid, amantadin, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 m\u1ed9t ho\u1eb7c c\u1ea3 hai thu\u1ed1c.<\/p>\n<p>\u1ede ng\u01b0\u1eddi cao tu\u1ed5i, ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u (\u0111\u1eb7c bi\u1ec7t l\u00e0 thiazid) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p>Pyrimethamin li\u1ec1u cao (&gt;25 mg\/tu\u1ea7n) khi d\u00f9ng c\u00f9ng cotrimoxazol c\u00f3 th\u1ec3 g\u00e2y thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3.<\/p>\n<p>Cotrimoxazol l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a warfarin do c\u1ea1nh tranh g\u1eafn protein v\u00e0 \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a; c\u1ea7n theo d\u00f5i INR.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a phenytoin b\u1ecb k\u00e9o d\u00e0i khi ph\u1ed1i h\u1ee3p, nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c phenytoin t\u0103ng.<\/p>\n<p>Trimethoprim l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 digoxin \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n cao tu\u1ed5i.<\/p>\n<p>Cotrimoxazol c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 methotrexat t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn x\u00e9t nghi\u1ec7m \u0111\u1ecbnh l\u01b0\u1ee3ng methotrexat.<\/p>\n<p>Khi d\u00f9ng v\u1edbi lamivudin, n\u1ed3ng \u0111\u1ed9 lamivudin t\u0103ng kho\u1ea3ng 40% nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a cotrimoxazol.<\/p>\n<p>C\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft nh\u00f3m sulfonylurea, m\u1eb7c d\u00f9 \u00edt g\u1eb7p.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c g\u00e2y t\u0103ng kali m\u00e1u.<\/p>\n<p>N\u1ebfu \u0111ang s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c kh\u00e1ng folat kh\u00e1c (nh\u01b0 methotrexat), n\u00ean b\u1ed5 sung th\u00eam acid folinic \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 thi\u1ebfu h\u1ee5t folat.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef mang thai: C\u00e1c thu\u1ed1c nh\u00f3m sulfonamid c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ea9y bilirubin kh\u1ecfi albumin, t\u1eeb \u0111\u00f3 g\u00e2y v\u00e0ng da \u1edf tr\u1ebb s\u01a1 sinh trong giai \u0111o\u1ea1n chu sinh. Do trimethoprim v\u00e0 sulfamethoxazol c\u00f3 th\u1ec3 can thi\u1ec7p v\u00e0o qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a acid folic, thu\u1ed1c ch\u1ec9 n\u00ean d\u00f9ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft trong thai k\u1ef3. N\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i s\u1eed d\u1ee5ng, c\u1ea7n b\u1ed5 sung th\u00eam acid folic \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 thi\u1ebfu h\u1ee5t.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: C\u1ea3 trimethoprim v\u00e0 sulfamethoxazol \u0111\u1ec1u b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9. V\u00ec tr\u1ebb s\u01a1 sinh r\u1ea5t nh\u1ea1y c\u1ea3m v\u1edbi t\u00e1c d\u1ee5ng \u0111\u1ed9c c\u1ee7a thu\u1ed1c, ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa kh\u00f4ng n\u00ean d\u00f9ng Babytrim-New.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u r\u00f5 r\u00e0ng v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a cotrimoxazol \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Tuy nhi\u00ean, do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n, c\u1ea7n c\u00e2n nh\u1eafc t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe th\u1ef1c t\u1ebf c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh tr\u01b0\u1edbc khi tham gia v\u00e0o c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 t\u1eadp trung cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p><em><strong>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u<\/strong><\/em><\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c d\u1ea5u hi\u1ec7u nh\u01b0 ch\u00e1n \u0103n, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au \u0111\u1ea7u, l\u01a1 m\u01a1 ho\u1eb7c b\u1ea5t t\u1ec9nh.<\/p>\n<p>V\u1ec1 l\u00e2u d\u00e0i, vi\u1ec7c d\u00f9ng qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn r\u1ed1i lo\u1ea1n qu\u00e1 tr\u00ecnh t\u1ea1o m\u00e1u ho\u1eb7c g\u00e2y v\u00e0ng da.<\/p>\n<p>\u1ee8c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng.<\/p>\n<p><em><strong>X\u1eed tr\u00ed<\/strong><\/em><\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p m\u1edbi u\u1ed1ng thu\u1ed1c qu\u00e1 li\u1ec1u, c\u00f3 th\u1ec3 g\u00e2y n\u00f4n ho\u1eb7c ti\u1ebfn h\u00e0nh r\u1eeda d\u1ea1 d\u00e0y \u0111\u1ec3 lo\u1ea1i b\u1ecf ph\u1ea7n thu\u1ed1c ch\u01b0a h\u1ea5p thu.<\/p>\n<p>C\u00f3 th\u1ec3 acid h\u00f3a n\u01b0\u1edbc ti\u1ec3u nh\u1eb1m t\u0103ng kh\u1ea3 n\u0103ng \u0111\u00e0o th\u1ea3i trimethoprim qua \u0111\u01b0\u1eddng th\u1eadn.<\/p>\n<p>N\u1ebfu xu\u1ea5t hi\u1ec7n \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng, c\u1ea7n s\u1eed d\u1ee5ng leucovorin (acid folinic) li\u1ec1u 5\u201315 mg\/ng\u00e0y cho \u0111\u1ebfn khi ch\u1ee9c n\u0103ng t\u1ea1o m\u00e1u h\u1ed3i ph\u1ee5c.<\/p>\n<p>L\u1ecdc m\u00e1u ngo\u00e0i th\u1eadn (th\u1ea9m ph\u00e2n m\u00e1u) ch\u1ec9 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf thu\u1ed1c, trong khi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c g\u1ea7n nh\u01b0 kh\u00f4ng mang l\u1ea1i hi\u1ec7u qu\u1ea3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Babytrim-New \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Babytrim-New trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Babytrim-New khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Babytrim-New nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/trimeseptol-400-80\/\">Trimeseptol 400\/80<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Sulfamethoxazol 400mg v\u00e0 Trimethoprim 80mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m H\u00e0 T\u00e2y, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng nhi\u1ec5m khu\u1ea9n<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/tolsus\/\">Tolsus<\/a> c\u00f3 th\u00e0nh ph\u1ea7n h\u00ednh l\u00e0 Sulfamethoxazol 200mg v\u00e0 Trimethoprim 40mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Polipharm Co., Ltd, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng nhi\u1ec5m khu\u1ea9n<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Babytrim-New \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/To-huong-dan-su-dung-Babytrim-New-vnras.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 22 th\u00e1ng 9 n\u0103m 2025<\/li>\n<li>Kemnic TR, Coleman M (2022). Trimethoprim Sulfamethoxazole. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Truy c\u1eadp ng\u00e0y 22 th\u00e1ng 9 n\u0103m 2025 t\u1eeb:: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513232\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513232\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Babytrim-New \u00e0 thu\u1ed1c b\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng, ph\u1ed1i h\u1ee3p gi\u1eefa sulfamethoxazol v\u00e0 trimethoprim, d\u00f9ng \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n do vi khu\u1ea9n nh\u1ea1y c\u1ea3m g\u00e2y ra<\/p>\n","protected":false},"author":1,"featured_media":140551,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-140490","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/140490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=140490"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/140551"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=140490"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=140490"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=140490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}