{"id":140359,"date":"2025-09-20T17:16:47","date_gmt":"2025-09-20T10:16:47","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=140359"},"modified":"2025-09-20T17:18:45","modified_gmt":"2025-09-20T10:18:45","slug":"tatanol-ultra","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tatanol-ultra\/","title":{"rendered":"Tatanol Ultra"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Tatanol Ultra \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n Pymepharco c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893111495324 (S\u0110K c\u0169: VD-28305-17)<\/strong><\/p>\n<h2>Tatanol Ultra l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Tatanol Ultra<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Tramadol hydroclorid:&#8230;&#8230;&#8230;&#8230;&#8230;..37,5mg<\/li>\n<li>Acetaminophen:&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.325mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Microcrystalline cellulose, tinh b\u1ed9t ti\u1ec1n gelatin h\u00f3a, hydroxypropyl cellulose, natri croscarmellose, polymethacrylat, natri lauryl sulfat, magnesi stearat, opadry II white, oxid s\u1eaft v\u00e0ng, opadry clear.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893111495324 (S\u0110K c\u0169: VD-28305-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tatanol Ultra<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p><em><strong>Acetaminophen<\/strong><\/em><\/p>\n<p>Acetaminophen l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a phenacetin, \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nh\u01b0 m\u1ed9t thu\u1ed1c h\u1ea1 s\u1ed1t, gi\u1ea3m \u0111au ph\u1ed5 bi\u1ebfn, c\u00f3 th\u1ec3 thay th\u1ebf aspirin trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p.<\/p>\n<p>Thu\u1ed1c gi\u00fap h\u1ea1 th\u00e2n nhi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n \u0111ang s\u1ed1t nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ch\u1ee7 y\u1ebfu th\u00f4ng qua v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i, gi\u00fap gi\u00e3n m\u1ea1ch v\u00e0 t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u ngo\u1ea1i bi\u00ean \u0111\u1ec3 t\u1ecfa nhi\u1ec7t.<\/p>\n<p>V\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb, acetaminophen \u00edt g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tim m\u1ea1ch v\u00e0 h\u00f4 h\u1ea5p, kh\u00f4ng l\u00e0m thay \u0111\u1ed5i c\u00e2n b\u1eb1ng ki\u1ec1m toan v\u00e0 kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng hay xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a nh\u01b0 nh\u00f3m salicylat.<\/p>\n<p><em><strong>Tramadol<\/strong> <\/em><\/p>\n<p>Tramadol l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au t\u00e1c \u0111\u1ed9ng trung \u01b0\u01a1ng, c\u00f3 hi\u1ec7u qu\u1ea3 r\u00f5 r\u1ec7t trong \u0111i\u1ec1u tr\u1ecb \u0111au. Ho\u1ea1t ch\u1ea5t n\u00e0y v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh (M1) c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 \u03bc-opioid, \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf nh\u1eb9 qu\u00e1 tr\u00ecnh t\u00e1i h\u1ea5p thu serotonin v\u00e0 norepinephrin, t\u1eeb \u0111\u00f3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 c\u1ee7a tramadol t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c opioid c\u1ed5 \u0111i\u1ec3n nh\u01b0ng \u01b0u \u0111i\u1ec3m l\u00e0 \u00edt g\u00e2y \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p \u2013 t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a nh\u00f3m thu\u1ed1c gi\u1ea3m \u0111au g\u00e2y nghi\u1ec7n.<\/p>\n<p><em><strong>S\u1ef1 ph\u1ed1i h\u1ee3p Acetaminophen v\u00e0 Tramadol<\/strong><\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y s\u1ef1 k\u1ebft h\u1ee3p hai ho\u1ea1t ch\u1ea5t t\u1ea1o ra t\u00e1c d\u1ee5ng hi\u1ec7p l\u1ef1c, gi\u00fap n\u00e2ng cao hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au so v\u1edbi khi d\u00f9ng ri\u00eang l\u1ebb.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p><em><strong>Acetaminophen<\/strong><\/em><\/p>\n<p>H\u1ea5p thu: Thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 h\u1ea7u nh\u01b0 ho\u00e0n to\u00e0n sau khi u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong m\u00e1u sau kho\u1ea3ng 1 \u2013 3 gi\u1edd. Vi\u1ec7c ph\u1ed1i h\u1ee3p c\u00f9ng tramadol kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u1eb7c \u0111i\u1ec3m h\u1ea5p thu.<\/p>\n<p>Ph\u00e2n b\u1ed1: Acetaminophen lan t\u1ecfa nhanh \u0111\u1ebfn h\u1ea7u h\u1ebft c\u00e1c m\u00f4 trong c\u01a1 th\u1ec3, tr\u1eeb m\u00f4 m\u1ee1; kho\u1ea3ng 25% l\u01b0\u1ee3ng thu\u1ed1c trong m\u00e1u g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: \u1ede li\u1ec1u \u0111i\u1ec1u tr\u1ecb, ph\u1ea7n l\u1edbn thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan nh\u1edd c\u00e1c ph\u1ea3n \u1ee9ng li\u00ean h\u1ee3p sulfat v\u00e0 glucuronid. M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf (&lt; 4%) b\u1ecb chuy\u1ec3n h\u00f3a qua h\u1ec7 cytochrom P450 th\u00e0nh N-acetyl-benzoquinonimin (NAPQ) \u2013 ch\u1ea5t c\u00f3 \u0111\u1ed9c t\u00ednh cao. B\u00ecnh th\u01b0\u1eddng NAPQ s\u1ebd \u0111\u01b0\u1ee3c trung h\u00f2a b\u1edfi glutathion v\u00e0 th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng li\u00ean h\u1ee3p cystein ho\u1eb7c mercapturat. Khi d\u00f9ng li\u1ec1u l\u1edbn, d\u1ef1 tr\u1eef glutathion \u1edf gan c\u1ea1n ki\u1ec7t, NAPQ t\u00edch l\u0169y v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ho\u1ea1i t\u1eed t\u1ebf b\u00e0o gan.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ho\u1ea1t ch\u1ea5t Acetaminophen trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 1 \u2013 4 gi\u1edd. Th\u00f4ng s\u1ed1 n\u00e0y th\u01b0\u1eddng kh\u00f4ng thay \u0111\u1ed5i \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn, nh\u01b0ng c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi qu\u00e1 li\u1ec1u c\u1ea5p, ng\u01b0\u1eddi m\u1eafc b\u1ec7nh gan, ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c tr\u1ebb s\u01a1 sinh. B\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng li\u00ean h\u1ee3p.<\/p>\n<p><em><strong>Tramadol hydroclorid<\/strong><\/em><\/p>\n<p>H\u1ea5p thu: D\u1ec5 d\u00e0ng h\u1ea5p thu qua \u0111\u01b0\u1eddng u\u1ed1ng, sinh kh\u1ea3 d\u1ee5ng trung b\u00ecnh kho\u1ea3ng 70\u201375%.<\/p>\n<p>Ph\u00e2n b\u1ed1: Li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 20%, ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp c\u01a1 th\u1ec3, qua \u0111\u01b0\u1ee3c nhau thai v\u00e0 ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf xu\u1ea5t hi\u1ec7n trong s\u1eefa m\u1eb9.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: \u0110\u01b0\u1ee3c chuy\u1ec3n h\u00f3a t\u1ea1i gan qua c\u00e1c isoenzym CYP3A4 v\u00e0 CYP2D6 th\u00f4ng qua qu\u00e1 tr\u00ecnh kh\u1eed N-methyl, O-methyl, sau \u0111\u00f3 li\u00ean h\u1ee3p v\u1edbi glucuronic ho\u1eb7c sulfat. Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 O-desmethyltramadol (M1), c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Ch\u1ee7 y\u1ebfu Tramadol hydroclorid d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c th\u1ea3i ra ngo\u00e0i c\u01a1 th\u1ec3 theo \u0111\u01b0\u1eddng n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a ho\u1ea1t ch\u1ea5t Tramadol l\u00e0 kho\u1ea3ng 6 gi\u1edd. C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a tramadol \u1edf ng\u01b0\u1eddi cao tu\u1ed5i kh\u00f4ng kh\u00e1c bi\u1ec7t nhi\u1ec1u so v\u1edbi ng\u01b0\u1eddi tr\u1ebb.<\/p>\n<h2>Thu\u1ed1c Tatanol Ultra \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Tatanol Ultra \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m gi\u1ea3m c\u00e1c c\u01a1n \u0111au m\u1ee9c \u0111\u1ed9 v\u1eeba \u0111\u1ebfn n\u1eb7ng, n\u01a1i c\u1ea7n hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au m\u1ea1nh h\u01a1n so v\u1edbi khi d\u00f9ng \u0111\u01a1n \u0111\u1ed9c acetaminophen ho\u1eb7c tramadol.<\/p>\n<figure id=\"attachment_140373\" aria-describedby=\"caption-attachment-140373\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-140373\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra.jpg\" alt=\"Tatanol Ultra\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Tatanol-Ultra-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-140373\" class=\"wp-caption-text\">Thu\u1ed1c Tatanol Ultra c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb nh\u1eefng c\u01a1n \u0111au t\u1eeb m\u1ee9c trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i: U\u1ed1ng 1 \u2013 2 vi\u00ean, c\u00e1ch nhau 4 \u2013 6 gi\u1edd t\u00f9y nhu c\u1ea7u, nh\u01b0ng kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 8 vi\u00ean trong 24 gi\u1edd.<\/p>\n<p>Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i: Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: \u1ede b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 75 tu\u1ed5i v\u00e0 kh\u00f4ng c\u00f3 suy gan, suy th\u1eadn, kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. V\u1edbi ng\u01b0\u1eddi tr\u00ean 75 tu\u1ed5i, th\u1eddi gian th\u1ea3i tr\u1eeb thu\u1ed1c c\u00f3 th\u1ec3 k\u00e9o d\u00e0i, do \u0111\u00f3 n\u00ean t\u0103ng kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c l\u1ea7n d\u00f9ng n\u1ebfu c\u1ea7n thi\u1ebft.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>C\u00f3 th\u1ec3 u\u1ed1ng <strong>vi\u00ean n\u00e9n Tatanol Ultra<\/strong> c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Tatanol Ultra trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>D\u1ecb \u1ee9ng v\u1edbi acetaminophen, tramadol ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Tatanol Ultra<\/p>\n<p>\u0110ang trong t\u00ecnh tr\u1ea1ng ng\u1ed9 \u0111\u1ed9c c\u1ea5p do r\u01b0\u1ee3u, thu\u1ed1c an th\u1ea7n, thu\u1ed1c ng\u1ee7, opioid ho\u1eb7c c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy h\u00f4 h\u1ea5p n\u1eb7ng.<\/p>\n<p>Ng\u01b0\u1eddi m\u1eafc suy gan ho\u1eb7c suy th\u1eadn m\u1ee9c \u0111\u1ed9 n\u1eb7ng.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh \u0111\u1ed9ng kinh nh\u01b0ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c b\u1eb1ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>\u0110ang d\u00f9ng ho\u1eb7c m\u1edbi ng\u01b0ng thu\u1ed1c \u1ee9c ch\u1ebf MAO trong v\u00f2ng 15 ng\u00e0y.<\/p>\n<p>Tr\u1ebb em d\u01b0\u1edbi 15 tu\u1ed5i.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi nhi\u1ec1u ch\u1ebf ph\u1ea9m c\u00f3 ch\u1ee9a acetaminophen v\u00e0 tramadol<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng v\u1edbi ng\u01b0\u1eddi suy gan, suy th\u1eadn, suy dinh d\u01b0\u1ee1ng, nghi\u1ec7n r\u01b0\u1ee3u ho\u1eb7c m\u1ea5t n\u01b0\u1edbc.<\/p>\n<p>C\u1ea7n tr\u00e1nh d\u00f9ng cho ng\u01b0\u1eddi c\u00f3 \u00fd \u0111\u1ecbnh t\u1ef1 s\u00e1t, ng\u01b0\u1eddi d\u1ec5 nghi\u1ec7n ho\u1eb7c \u0111ang nghi\u1ec7n r\u01b0\u1ee3u.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh \u0111\u1ed9ng kinh, ch\u1ea5n th\u01b0\u01a1ng s\u1ecd n\u00e3o, t\u0103ng \u00e1p l\u1ef1c n\u1ed9i s\u1ecd ho\u1eb7c r\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p c\u1ea7n \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd.<\/p>\n<p>Ng\u01b0ng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t sau khi d\u00f9ng Tatanol Ultra d\u00e0i ng\u00e0y c\u00f3 th\u1ec3 g\u00e2y h\u1ed9i ch\u1ee9ng cai thu\u1ed1c.<\/p>\n<p>Khi ph\u1ea3i ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, c\u1ea7n gi\u1ea3m li\u1ec1u tramadol \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p v\u00e0 co gi\u1eadt.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Tr\u00ean da v\u00e0 ni\u00eam m\u1ea1c: C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ph\u00e1t ban, n\u1ed5i m\u1ec1 \u0111ay, ng\u1ee9a, ph\u00f9 m\u1ea1ch ho\u1eb7c ph\u00f9 thanh qu\u1ea3n. M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm g\u1eb7p nh\u01b0ng nghi\u00eam tr\u1ecdng h\u01a1n l\u00e0 h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN), h\u1ed9i ch\u1ee9ng Lyell, hay ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p t\u00ednh (AGEP). C\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng \u0111e d\u1ecda t\u00ednh m\u1ea1ng n\u00ean c\u1ea7n ng\u1eebng thu\u1ed1c ngay khi c\u00f3 d\u1ea5u hi\u1ec7u b\u1ea5t th\u01b0\u1eddng tr\u00ean da.<\/p>\n<p>Huy\u1ebft h\u1ecdc: Gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh ho\u1eb7c th\u1eadm ch\u00ed m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng li\u1ec1u cao ho\u1eb7c k\u00e9o d\u00e0i.<\/p>\n<p>Th\u1ea7n kinh \u2013 t\u00e2m th\u1ea7n: C\u00f3 th\u1ec3 g\u1eb7p bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, m\u1ec7t m\u1ecfi, l\u00fa l\u1eabn, thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, tramadol g\u00e2y co gi\u1eadt, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 ho\u1eb7c khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c l\u00e0m gi\u1ea3m ng\u01b0\u1ee1ng co gi\u1eadt.<\/p>\n<p>Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y ho\u1eb7c t\u00e1o b\u00f3n.<\/p>\n<p>Kh\u00e1c: D\u00f9ng l\u00e2u d\u00e0i c\u00f3 th\u1ec3 g\u00e2y dung n\u1ea1p thu\u1ed1c, l\u1ec7 thu\u1ed9c thu\u1ed1c v\u00e0 h\u1ed9i ch\u1ee9ng cai n\u1ebfu ng\u1eebng \u0111\u1ed9t ng\u1ed9t.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>V\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng (nh\u01b0 r\u01b0\u1ee3u, thu\u1ed1c ng\u1ee7, thu\u1ed1c an th\u1ea7n, opioid kh\u00e1c, thu\u1ed1c g\u00e2y m\u00ea, thu\u1ed1c t\u00ea): nguy c\u01a1 \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p v\u00e0 an th\u1ea7n t\u0103ng r\u00f5 r\u1ec7t, c\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>V\u1edbi thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (SSRI, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng, MAOI): l\u00e0m t\u0103ng nguy c\u01a1 co gi\u1eadt v\u00e0 c\u00f3 th\u1ec3 g\u00e2y h\u1ed9i ch\u1ee9ng serotonin. \u0110\u1eb7c bi\u1ec7t, tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf MAO trong v\u00f2ng 15 ng\u00e0y.<\/p>\n<p>V\u1edbi naloxon: c\u00f3 th\u1ec3 d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u tramadol, tuy nhi\u00ean thu\u1ed1c \u0111\u1ed1i kh\u00e1ng n\u00e0y l\u1ea1i l\u00e0m t\u0103ng nguy c\u01a1 co gi\u1eadt.<\/p>\n<p>V\u1edbi c\u00e1c thu\u1ed1c ho\u1eb7c ch\u1ebf ph\u1ea9m ch\u1ee9a acetaminophen kh\u00e1c: d\u1ec5 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng qu\u00e1 li\u1ec1u, g\u00e2y \u0111\u1ed9c t\u00ednh gan.<\/p>\n<p>Ng\u01b0\u1eddi u\u1ed1ng r\u01b0\u1ee3u nhi\u1ec1u ho\u1eb7c nghi\u1ec7n r\u01b0\u1ee3u: nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng gan t\u0103ng m\u1ea1nh khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi acetaminophen.<\/p>\n<p>Ng\u01b0\u1eddi c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 30 ml\/ph\u00fat: c\u1ea7n h\u1ea1n ch\u1ebf li\u1ec1u, kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 2 vi\u00ean m\u1ed7i 12 gi\u1edd.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p><em><strong>Trong thai k\u1ef3<\/strong><\/em><\/p>\n<p>Tramadol c\u00f3 kh\u1ea3 n\u0103ng \u0111i qua h\u00e0ng r\u00e0o nhau thai. M\u1ed9t s\u1ed1 b\u00e1o c\u00e1o cho th\u1ea5y vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y trong giai \u0111o\u1ea1n mang thai c\u00f3 th\u1ec3 g\u00e2y ra c\u01a1n co gi\u1eadt \u1edf tr\u1ebb s\u01a1 sinh, h\u1ed9i ch\u1ee9ng cai thu\u1ed1c, th\u1eadm ch\u00ed ghi nh\u1eadn tr\u01b0\u1eddng h\u1ee3p thai l\u01b0u ho\u1eb7c tr\u1ebb t\u1eed vong sau sinh.<\/p>\n<p>Ch\u1ec9 n\u00ean d\u00f9ng tramadol cho ph\u1ee5 n\u1eef mang thai khi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb r\u00f5 r\u00e0ng v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1 ti\u1ec1m \u1ea9n cho thai nhi. \u0110\u1eb7c bi\u1ec7t, kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tramadol ngay tr\u01b0\u1edbc ho\u1eb7c trong qu\u00e1 tr\u00ecnh chuy\u1ec3n d\u1ea1 \u0111\u1ec3 tr\u00e1nh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb.<\/p>\n<p>\u0110\u1ed1i v\u1edbi acetaminophen, hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u kh\u1eb3ng \u0111\u1ecbnh ch\u1eafc ch\u1eafn v\u1ec1 \u0111\u1ed9 an to\u00e0n khi d\u00f9ng trong thai k\u1ef3. Tuy nhi\u00ean, v\u00ec thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thai nhi n\u00ean ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<p><em><strong>Trong th\u1eddi gian cho con b\u00fa<\/strong><\/em><\/p>\n<p>Tramadol c\u00f3 th\u1ec3 ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u1edbi t\u1ef7 l\u1ec7 r\u1ea5t nh\u1ecf (kho\u1ea3ng 0,1%), nh\u01b0ng do tr\u1ebb s\u01a1 sinh \u0111\u1eb7c bi\u1ec7t nh\u1ea1y c\u1ea3m v\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c, n\u00ean ph\u1ee5 n\u1eef \u0111ang d\u00f9ng tramadol kh\u00f4ng \u0111\u01b0\u1ee3c cho con b\u00fa.<\/p>\n<p>V\u1edbi acetaminophen, nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y thu\u1ed1c h\u1ea7u nh\u01b0 kh\u00f4ng g\u00e2y t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i cho tr\u1ebb b\u00fa m\u1eb9, do \u0111\u00f3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u1edf li\u1ec1u th\u00f4ng th\u01b0\u1eddng nh\u01b0ng v\u1eabn c\u1ea7n s\u1ef1 gi\u00e1m s\u00e1t y t\u1ebf.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Tramadol c\u00f3 th\u1ec3 g\u00e2y \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, gi\u1ea3m kh\u1ea3 n\u0103ng t\u1eadp trung v\u00e0 ph\u1ea3n x\u1ea1. Nh\u1eefng t\u00e1c \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng l\u00e0m vi\u1ec7c tr\u00ed \u00f3c c\u0169ng nh\u01b0 ho\u1ea1t \u0111\u1ed9ng th\u1ec3 ch\u1ea5t.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o th\u1eadn tr\u1ecdng khi l\u00e1i xe, \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n giao th\u00f4ng ho\u1eb7c v\u1eadn h\u00e0nh c\u00e1c lo\u1ea1i m\u00e1y m\u00f3c \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p><em><strong>Acetaminophen<\/strong><\/em><\/p>\n<p>Qu\u00e1 li\u1ec1u th\u01b0\u1eddng x\u1ea3y ra khi d\u00f9ng li\u1ec1u l\u1edbn m\u1ed9t l\u1ea7n ho\u1eb7c l\u1eb7p l\u1ea1i li\u1ec1u cao trong nhi\u1ec1u ng\u00e0y. T\u00e1c d\u1ee5ng \u0111\u1ed9c t\u00ednh nghi\u00eam tr\u1ecdng nh\u1ea5t l\u00e0 ho\u1ea1i t\u1eed gan c\u1ea5p, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy gan v\u00e0 t\u1eed vong.<\/p>\n<p>Tri\u1ec7u ch\u1ee9ng s\u1edbm g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, xanh t\u00edm ni\u00eam m\u1ea1c do methemoglobin. T\u1ed5n th\u01b0\u01a1ng gan th\u01b0\u1eddng r\u00f5 r\u1ec7t sau 2 \u2013 4 ng\u00e0y.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u1ea7n ch\u1ea9n \u0111o\u00e1n s\u1edbm, r\u1eeda d\u1ea1 d\u00e0y trong 4 gi\u1edd \u0111\u1ea7u v\u00e0 d\u00f9ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c N-acetylcystein c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t (t\u1ed1t nh\u1ea5t tr\u01b0\u1edbc 10 gi\u1edd). N\u1ebfu kh\u00f4ng c\u00f3 N-acetylcystein, c\u00f3 th\u1ec3 thay th\u1ebf b\u1eb1ng methionin. Ngo\u00e0i ra, than ho\u1ea1t ho\u1eb7c thu\u1ed1c t\u1ea9y mu\u1ed1i c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 gi\u1ea3m h\u1ea5p thu thu\u1ed1c.<\/p>\n<p><em><strong>Tramadol<\/strong><\/em><\/p>\n<p>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c phi\u1ec7n, bao g\u1ed3m suy h\u00f4 h\u1ea5p, h\u00f4n m\u00ea, nh\u01b0\u1ee3c c\u01a1, co gi\u1eadt, h\u1ea1 huy\u1ebft \u00e1p, ng\u1eebng tim.<\/p>\n<p>X\u1eed tr\u00ed ch\u1ee7 y\u1ebfu l\u00e0 duy tr\u00ec th\u00f4ng kh\u00ed, h\u1ed7 tr\u1ee3 tu\u1ea7n ho\u00e0n v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng. Thu\u1ed1c \u0111\u1ed1i kh\u00e1ng opioid nh\u01b0 naloxon c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c m\u1ed9t ph\u1ea7n tri\u1ec7u ch\u1ee9ng, nh\u01b0ng c\u1ea7n l\u01b0u \u00fd nguy c\u01a1 l\u00e0m t\u0103ng co gi\u1eadt.<\/p>\n<p>Th\u1ea9m t\u00e1ch m\u00e1u kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 v\u00ec ch\u1ec9 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf tramadol kh\u1ecfi c\u01a1 th\u1ec3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Tatanol Ultra \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Tatanol Ultra trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Tatanol Ultra khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Tatanol Ultra nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/lofacef\/\">Lofacef 325mg\/37.5mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol 325mg v\u00e0 Tramadol 37,5mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c Trung \u01b0\u01a1ng Mediplantex, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 gi\u1ea3m \u0111au t\u1eeb v\u1eeba \u0111\u1ebfn n\u1eb7ng<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/dolifen-tab\/\">Dolifen tab<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol v\u00e0 Tramadol, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Samchungdang Pharm. Co. LTD, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 gi\u1ea3m \u0111au t\u1eeb v\u1eeba \u0111\u1ebfn n\u1eb7ng<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Mor\u00f3n Merchante I, Pergolizzi JV Jr, van de Laar M, Mellinghoff HU, Nalamachu S, O&#8217;Brien J, Perrot S, Raffa RB (2013). Tramadol\/Paracetamol fixed-dose combination for chronic pain management in family practice: a clinical review. ISRN Family Med. Truy c\u1eadp ng\u00e0y 20 th\u00e1ng 9 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4041254\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4041254\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Tatanol Ultra l\u00e0 thu\u1ed1c ph\u1ed1i h\u1ee3p gi\u1eefa Tramadol hydroclorid v\u00e0 Acetaminophen 37.5mg\/325mg, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1eefng c\u01a1n \u0111au t\u1eeb m\u1ee9c trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng<\/p>\n","protected":false},"author":1,"featured_media":140365,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-140359","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/140359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=140359"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/140365"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=140359"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=140359"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=140359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}