{"id":140265,"date":"2025-09-29T05:04:34","date_gmt":"2025-09-28T22:04:34","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=140265"},"modified":"2025-09-29T05:21:39","modified_gmt":"2025-09-28T22:21:39","slug":"coldko","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/coldko\/","title":{"rendered":"Coldko"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <\/strong><a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/coldko\/\">Coldko<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m Nam H\u00e0, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-22731-15.<\/strong><\/p>\n<h2>Coldko l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Thu\u1ed1c Coldko<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Paracetamol (Acetaminophen) 500mg<\/li>\n<li>Chlorpheniramine maleate 2mg<\/li>\n<li>Dextromethorphan HBr 10mg<\/li>\n<li>Ph\u1ee5 li\u1ec7u v\u0111<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean s\u1ee7i<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-22731-15<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_142308\" aria-describedby=\"caption-attachment-142308\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-142308\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko.jpg\" alt=\" coldko\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/coldko-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-142308\" class=\"wp-caption-text\">Coldko \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam, c\u1ea3m l\u1ea1nh<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Coldko<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Chlorpheniramin c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng histamin H1, gi\u1ea3m tri\u1ec7u ch\u1ee9ng d\u1ecb \u1ee9ng. Ngo\u00e0i ra, c\u00f2n t\u00e1c d\u1ee5ng l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, gi\u00fap an th\u1ea7n nh\u1eb9.<\/p>\n<p>Dextromethorphan c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m ho b\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean trung t\u00e2m \u0111i\u1ec1u khi\u1ec3n ho, hi\u1ec7u qu\u1ea3 trong ho khan.<\/p>\n<p>Paracetamol c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t b\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i, gi\u1ea3m \u0111au nh\u1eb9 \u0111\u1ebfn v\u1eeba nh\u1edd t\u00e1c \u0111\u1ed9ng ngo\u1ea1i bi\u00ean.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Dextromethorphth\u1ea3iomethorphan, Chlorpheniramin h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. T\u00e1c d\u1ee5ng xu\u1ea5t hi\u1ec7n trong v\u00f2ng 15 &#8211; 60 ph\u00fat sau u\u1ed1ng.<\/li>\n<li>Ph\u00e2n b\u1ed1: Paracetamol ph\u00e2n b\u1ed1 \u0111\u1ec1u kh\u1eafp m\u00f4. Kho\u1ea3ng 25-70% ho\u1ea1t ch\u1ea5t g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Paracetamol chuy\u1ec3n ho\u00e1 \u1edf gan, t\u1ea1o ch\u1ea5t trung gian NAPQ c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c gan n\u1ebfu qu\u00e1 li\u1ec1u. Dextromethorphan \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan b\u1edfi CYP2D6. Chlorpheniramin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Paracetamol 1.25\u20133 gi\u1edd, Chlorpheniramin l\u00e0 12\u201315 gi\u1edd (c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn), Dextromethorphan l\u00e0 3\u20136 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Coldko tr\u1ecb b\u1ec7nh g\u00ec?<\/h2>\n<p>Coldko \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam th\u00f4ng th\u01b0\u1eddng nh\u01b0: S\u1ed1t, nh\u1ee9c \u0111\u1ea7u, \u0111au m\u1ecfi c\u01a1 th\u1ec3, ngh\u1eb9t m\u0169i, ch\u1ea3y n\u01b0\u1edbc m\u0169i, h\u1eaft h\u01a1i, ho khan do k\u00edch th\u00edch nh\u1eb9 \u1edf h\u1ecdng v\u00e0 ph\u1ebf qu\u1ea3n.<\/p>\n<h2>Li\u1ec1u d\u00f9ng-C\u00e1ch d\u00f9ng Coldko<\/h2>\n<h3>Li\u1ec1u d\u00f9ng Coldko<\/h3>\n<p>T\u00f9y theo tr\u01b0\u1eddng h\u1ee3p m\u00e0 \u0111\u01b0\u1ee3c b\u00e1c s\u0129 ch\u1ec9 \u0111\u1ecbnh li\u1ec1u d\u00f9ng kh\u00e1c nhau, d\u01b0\u1edbi \u0111\u00e2y l\u00e0 li\u1ec1u d\u00f9ng tham kh\u1ea3o.<\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb tr\u00ean 12 tu\u1ed5i: u\u1ed1ng 1 vi\u00ean\/l\u1ea7n, t\u1ed1i \u0111a 6 vi\u00ean\/ng\u00e0y.<\/p>\n<p>Tr\u1ebb t\u1eeb 7\u201312 tu\u1ed5i: u\u1ed1ng \u00bd \u2013 1 vi\u00ean\/l\u1ea7n, t\u1ed1i \u0111a 4 vi\u00ean\/ng\u00e0y.<\/p>\n<p>Tr\u1ebb t\u1eeb 2\u20136 tu\u1ed5i: u\u1ed1ng \u00bd vi\u00ean\/l\u1ea7n, t\u1ed1i \u0111a 2 vi\u00ean\/ng\u00e0y.<\/p>\n<p>Kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c li\u1ec1u: 4\u20136 gi\u1edd.<\/p>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p><strong>Vi\u00ean s\u1ee7i tr\u1ecb c\u1ea3m c\u00fam Coldko<\/strong> d\u00f9ng \u0111\u1ec3 u\u1ed1ng.<\/p>\n<p>H\u00f2a tan ho\u00e0n to\u00e0n 1 vi\u00ean v\u00e0o 200ml n\u01b0\u1edbc tr\u01b0\u1edbc khi u\u1ed1ng.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Coldko trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Coldko cho ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o trong thu\u1ed1c.<\/p>\n<p>Suy gan, suy th\u1eadn n\u1eb7ng.<\/p>\n<p>Thi\u1ebfu h\u1ee5t men G6PD.<\/p>\n<p>\u0110ang d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf MAO.<\/p>\n<p>\u0110ang l\u00ean c\u01a1n hen c\u1ea5p.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Kh\u00f4ng d\u00f9ng chung v\u1edbi thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t \u0111\u1ec3 tr\u00e1nh qu\u00e1 li\u1ec1u.<\/p>\n<p>Kh\u00f4ng u\u1ed1ng r\u01b0\u1ee3u (t\u0103ng \u0111\u1ed9c t\u00ednh tr\u00ean gan v\u00e0 t\u0103ng bu\u1ed3n ng\u1ee7).<\/p>\n<p>Th\u1eadn tr\u1ecdng v\u1edbi ng\u01b0\u1eddi c\u00f3 b\u1ec7nh h\u00f4 h\u1ea5p m\u1ea1n (hen, COPD), ng\u01b0\u1eddi b\u1ecb gl\u00f4c\u00f4m, ng\u01b0\u1eddi b\u1ec7nh gan, th\u1eadn, ph\u00ec \u0111\u1ea1i ti\u1ec1n li\u1ec7t tuy\u1ebfn.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng<\/p>\n<p>Dextromethorphan c\u00f3 th\u1ec3 g\u00e2y ph\u1ee5 thu\u1ed9c n\u1ebfu d\u00f9ng l\u00e2u d\u00e0i li\u1ec1u cao.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5 Coldko<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p (&gt;1\/100):<\/p>\n<ul>\n<li>Ban \u0111\u1ecf, m\u1ec1 \u0111ay.<\/li>\n<\/ul>\n<p>\u00cdt g\u1eb7p (1\/1000 &#8211; 1\/100):<\/p>\n<ul>\n<li>Bu\u1ed3n ng\u1ee7, m\u1ec7t, ch\u00f3ng m\u1eb7t, kh\u00f4 mi\u1ec7ng.<\/li>\n<li>Bu\u1ed3n n\u00f4n, d\u1ecb \u1ee9ng da.<\/li>\n<\/ul>\n<p>Hi\u1ebfm g\u1eb7p (&lt;1\/1000):<\/p>\n<ul>\n<li>R\u1ed1i lo\u1ea1n m\u00e1u: Gi\u1ea3m b\u1ea1ch c\u1ea7u, thi\u1ebfu m\u00e1u.<\/li>\n<li>D\u1ecb \u1ee9ng nghi\u00eam tr\u1ecdng: SJS, TEN, Lyell, AGEP.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef mang thai: Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng, tr\u1eeb khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh t\u1eeb b\u00e1c s\u0129.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Tr\u00e1nh d\u00f9ng cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa, v\u00ec c\u00e1c ho\u1ea1t ch\u1ea5t c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, hoa m\u1eaft, ch\u00f3ng m\u1eb7t do \u0111\u00f3 kh\u00f4ng n\u00ean l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c trong th\u1eddi gian d\u00f9ng thu\u1ed1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u Paracetamol:<\/p>\n<ul>\n<li>Nguy hi\u1ec3m nh\u1ea5t ho\u1ea1i t\u1eed gan, c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong. Tri\u1ec7u ch\u1ee9ng s\u1edbm bu\u1ed3n n\u00f4n, n\u00f4n, m\u1ec7t, \u0111au b\u1ee5ng. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch R\u1eeda d\u1ea1 d\u00e0y s\u1edbm (trong 4h). D\u00f9ng N-acetylcystein c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t (u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch). Theo d\u00f5i men gan, bilirubin, \u0111\u00f4ng m\u00e1u.<\/li>\n<\/ul>\n<p>Qu\u00e1 li\u1ec1u Dextromethorphan:<\/p>\n<ul>\n<li>G\u00e2y bu\u1ed3n ng\u1ee7, \u1ea3o gi\u00e1c, m\u1ea5t ph\u1ed1i h\u1ee3p, co gi\u1eadt. \u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 d\u00f9ng Naloxon ti\u00eam t\u0129nh m\u1ea1ch (li\u1ec1u t\u1ed1i \u0111a 10mg).<\/li>\n<\/ul>\n<p>Qu\u00e1 li\u1ec1u Chlorpheniramin:<\/p>\n<ul>\n<li>Co gi\u1eadt, lo\u1ea1n t\u00e2m th\u1ea7n, ng\u01b0ng th\u1edf. \u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 h\u00f4 h\u1ea5p \u2013 tu\u1ea7n ho\u00e0n, diazepam\/phenytoin n\u1ebfu co gi\u1eadt.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h3>\n<p>Kh\u00f4ng d\u00f9ng chung v\u1edbi: thu\u1ed1c IMAO (\u1ee9c ch\u1ebf monoamin oxidase), r\u01b0\u1ee3u, c\u00e1c thu\u1ed1c c\u00f3 th\u00e0nh ph\u1ea7n t\u01b0\u01a1ng t\u1ef1 (paracetamol, dextromethorphan&#8230;).<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>N\u01a1i tho\u00e1ng m\u00e1t, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p>Tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp v\u00e0 n\u01a1i \u1ea9m \u01b0\u1edbt.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Coldko nh\u01b0:<\/p>\n<ul>\n<li><a href=\"https:\/\/vnras.com\/drug\/sara-for-children-250mg-5ml\/\" data-mil=\"136698\">SaRa For Children 250mg\/5ml<\/a> do C\u00f4ng ty TNHH Thai Nakorn Patana Vi\u1ec7t Nam s\u1ea3n xu\u1ea5t, c\u00f3 t\u00e1c d\u1ee5ng gi\u00fap gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t cho tr\u1ebb.<\/li>\n<li><a href=\"https:\/\/vnras.com\/drug\/siro-decolgen-untied\/\" data-mil=\"136698\">Siro Decolgen Untied<\/a> do C\u00f4ng ty TNHH United International Pharma s\u1ea3n xu\u1ea5t, \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m l\u1ea1nh th\u00f4ng th\u01b0\u1eddng, vi\u00eam c\u1ee7a \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p class=\"heading-title\">Chlorpheniramine, an Old Drug with New Potential Clinical Applications: A Comprehensive Review of the Literature, truy c\u1eadp ng\u00e0y 21 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35652393\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35652393\/.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Coldko \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam th\u00f4ng th\u01b0\u1eddng nh\u01b0 s\u1ed1t, nh\u1ee9c \u0111\u1ea7u, \u0111au m\u1ecfi c\u01a1 th\u1ec3, ngh\u1eb9t m\u0169i, ch\u1ea3y n\u01b0\u1edbc m\u0169i, h\u1eaft h\u01a1i, ho khan do k\u00edch th\u00edch nh\u1eb9 \u1edf h\u1ecdng v\u00e0 ph\u1ebf qu\u1ea3n.<\/p>\n","protected":false},"author":1,"featured_media":142309,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-140265","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/140265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=140265"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/142309"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=140265"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=140265"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=140265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}