{"id":139799,"date":"2025-09-18T15:26:18","date_gmt":"2025-09-18T08:26:18","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=139799"},"modified":"2025-09-18T17:01:54","modified_gmt":"2025-09-18T10:01:54","slug":"tagrisso-80mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tagrisso-80mg\/","title":{"rendered":"Tagrisso 80mg"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Tagrisso 80mg c\u00f3 c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t l\u00e0 AstraZeneca AB, \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 VN3-36-18.<\/strong><\/p>\n<h2 style=\"text-align: justify;\">Tagrisso 80mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3 style=\"text-align: justify;\">Th\u00e0nh ph\u1ea7n<\/h3>\n<p style=\"text-align: justify;\">M\u1ed7i vi\u00ean<strong> Tagrisso 80mg <\/strong>ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul style=\"text-align: justify;\">\n<li>Osimertinib (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 95,4 mg Osimertinib mesylat) 80mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">D\u1ea1ng b\u00e0o ch\u1ebf : Vi\u00ean n\u00e9n bao phim<\/p>\n<h3 style=\"text-align: justify;\">Tr\u00ecnh b\u00e0y<\/h3>\n<p style=\"text-align: justify;\">S\u0110K: VN3-36-18<\/p>\n<p style=\"text-align: justify;\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p style=\"text-align: justify;\">Xu\u1ea5t x\u1ee9: Th\u1ee5y \u0110i\u1ec3n<\/p>\n<h2 style=\"text-align: justify;\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tagrisso 80mg<\/h2>\n<h3 style=\"text-align: justify;\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Osimertinib l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf tyrosine kinase th\u1ebf h\u1ec7 ba g\u1eafn b\u1ea5t h\u1ed3i v\u1edbi v\u1ecb tr\u00ed ATP c\u1ee7a th\u1ee5 th\u1ec3 EGFR qua li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb t\u1ea1i cysteine 797 n\u00ean \u1ee9c ch\u1ebf c\u1ea3 c\u00e1c \u0111\u1ed9t bi\u1ebfn nh\u1ea1y c\u1ea3m c\u1ee7a EGFR v\u00e0 \u0111\u1ed9t bi\u1ebfn \u0111\u1ec1 kh\u00e1ng T790M trong khi \u00edt \u1ee9c ch\u1ebf EGFR d\u00f2ng hoang d\u00e3.<\/p>\n<p>Nghi\u00ean c\u1ee9u in vitro cho th\u1ea5y osimertinib \u1ee9c ch\u1ebf phospho-EGFR \u1edf c\u00e1c d\u00f2ng t\u1ebf b\u00e0o mang \u0111\u1ed9t bi\u1ebfn EGFR nh\u1ea1y c\u1ea3m v\u00e0 T790M v\u1edbi IC50 \u1edf ng\u01b0\u1ee1ng nano mol th\u1ea5p l\u00e0m gi\u1ea3m t\u0103ng tr\u01b0\u1edfng t\u1ebf b\u00e0o. Th\u1eed nghi\u1ec7m in vivo tr\u00ean m\u00f4 h\u00ecnh gh\u00e9p kh\u1ed1i u v\u00e0 chu\u1ed9t chuy\u1ec3n gen cho th\u1ea5y d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng d\u1eabn t\u1edbi thu nh\u1ecf kh\u1ed1i u \u1edf t\u1ebf b\u00e0o mang EGFRm v\u00e0 T790M m\u00e0 \u00edt \u1ea3nh h\u01b0\u1edfng tr\u00ean t\u1ebf b\u00e0o EGFR hoang d\u00e3. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ghi nh\u1eadn ho\u1ea1t t\u00ednh l\u00e2m s\u00e0ng v\u00e0 c\u1ea3i thi\u1ec7n so v\u1edbi h\u00f3a tr\u1ecb \u1edf b\u1ec7nh nh\u00e2n T790M d\u01b0\u01a1ng t\u00ednh.<\/p>\n<h3 style=\"text-align: justify;\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu : Sau khi u\u1ed1ng Tagrisso 80mg, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a osimertinib xu\u1ea5t hi\u1ec7n kho\u1ea3ng 6 gi\u1edd sau d\u00f9ng. Th\u1ee9c \u0103n kh\u00f4ng l\u00e0m thay \u0111\u1ed5i sinh kh\u1ea3 d\u1ee5ng theo \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p>Ph\u00e2n b\u1ed1 : Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 900 \u0111\u1ebfn 997 l\u00edt, cho th\u1ea5y ph\u00e2n b\u1ed1 r\u1ed9ng v\u00e0o m\u00f4. Osimertinib c\u00f3 kh\u1ea3 n\u0103ng th\u1ea5m v\u00e0o n\u00e3o, ph\u00f9 h\u1ee3p v\u1edbi ho\u1ea1t t\u00ednh tr\u00ean di c\u0103n n\u00e3o.<\/p>\n<p>Chuy\u1ec3n h\u00f3a : Osimertinib chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua CYP3A4 v\u00e0 CYP3A5 t\u1ea1o hai ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t t\u00ednh l\u00e0 AZ7550 v\u00e0 AZ5104. AZ7550 c\u00f3 ho\u1ea1t t\u00ednh t\u01b0\u01a1ng \u0111\u01b0\u01a1ng c\u00f2n AZ5104 c\u00f3 hi\u1ec7u l\u1ef1c m\u1ea1nh h\u01a1n tr\u00ean EGFR.<\/p>\n<p>Th\u1ea3i tr\u1eeb : Ph\u1ea7n l\u1edbn li\u1ec1u \u0111\u01b0\u1ee3c th\u1ea3i qua ph\u00e2n kho\u1ea3ng 66 \u0111\u1ebfn 68%. Th\u1eddi gian b\u00e1n th\u1ea3i cu\u1ed1i c\u00f9ng \u01b0\u1edbc t\u00ednh kho\u1ea3ng 48 gi\u1edd.<\/p>\n<h2 style=\"text-align: justify;\">Tagrisso 80mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p style=\"text-align: justify;\"><strong>Tagrisso 80mg Osimertinib<\/strong>\u00a0\u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c di c\u0103n c\u00f3 \u0111\u1ed9t bi\u1ebfn EGFR T790M d\u01b0\u01a1ng t\u00ednh sau khi ti\u1ebfn tri\u1ec3n tr\u00ean li\u1ec7u ph\u00e1p EGFR TKI ban \u0111\u1ea7u.<\/p>\n<figure id=\"attachment_139800\" aria-describedby=\"caption-attachment-139800\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-139800\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi.jpg\" alt=\"Tagrisso 80mg \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/tagrisso-80mg-dieu-tri-ung-thu-phoi-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-139800\" class=\"wp-caption-text\">Tagrisso 80mg \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i<\/figcaption><\/figure>\n<h2 style=\"text-align: justify;\">Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Tagrisso 80mg<\/h2>\n<p>Khuy\u1ebfn c\u00e1o b\u1eaft \u0111\u1ea7u v\u00e0 theo d\u00f5i b\u1edfi b\u00e1c s\u0129 c\u00f3 kinh nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb kh\u00e1ng ung th\u01b0. Tr\u01b0\u1edbc khi d\u00f9ng c\u1ea7n x\u00e1c \u0111\u1ecbnh \u0111\u1ed9t bi\u1ebfn EGFR T790M b\u1eb1ng x\u00e9t nghi\u1ec7m \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn.<\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 1 vi\u00ean\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y. D\u00f9ng li\u00ean t\u1ee5c cho \u0111\u1ebfn khi b\u1ec7nh ti\u1ebfn tri\u1ec3n ho\u1eb7c xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh kh\u00f4ng ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c.<\/p>\n<p>N\u1ebfu qu\u00ean 1 li\u1ec1u, u\u1ed1ng ngay khi nh\u1edb tr\u1eeb khi li\u1ec1u k\u1ebf ti\u1ebfp c\u00f2n trong v\u00f2ng 12 gi\u1edd th\u00ec b\u1ecf li\u1ec1u \u0111\u00e3 qu\u00ean v\u00e0 ti\u1ebfp t\u1ee5c l\u1ecbch u\u1ed1ng b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>Ng\u01b0ng ho\u1eb7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u00f9y theo \u0111\u1ed9 n\u1eb7ng c\u1ee7a ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p. N\u1ebfu c\u1ea7n gi\u1ea3m li\u1ec1u, gi\u1ea3m xu\u1ed1ng 40mg\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y.<\/p>\n<h2 style=\"text-align: justify;\">C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Tagrisso 80mg<\/h2>\n<p>Nu\u1ed1t nguy\u00ean vi\u00ean v\u1edbi n\u01b0\u1edbc, kh\u00f4ng nghi\u1ec1n, kh\u00f4ng b\u1ebb, kh\u00f4ng nhai.<\/p>\n<p>N\u1ebfu b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 nu\u1ed1t nguy\u00ean vi\u00ean, th\u1ea3 nguy\u00ean vi\u00ean v\u00e0o 50ml n\u01b0\u1edbc kh\u00f4ng c\u00f3 carbonate, khu\u1ea5y \u0111\u1ec1u \u0111\u1ebfn khi vi\u00ean ph\u00e2n t\u00e1n th\u00e0nh m\u1ea3nh nh\u1ecf r\u1ed3i u\u1ed1ng ngay. Th\u00eam n\u1eeda ly n\u01b0\u1edbc \u0111\u1ec3 tr\u00e1ng ly v\u00e0 u\u1ed1ng ngay. Kh\u00f4ng d\u00f9ng ch\u1ea5t l\u1ecfng kh\u00e1c.<\/p>\n<p>N\u1ebfu d\u00f9ng qua \u1ed1ng th\u00f4ng d\u1ea1 d\u00e0y, pha nh\u01b0 tr\u00ean nh\u01b0ng d\u00f9ng 15ml n\u01b0\u1edbc l\u1ea7n \u0111\u1ea7u v\u00e0 15ml \u0111\u1ec3 tr\u00e1ng c\u1eb7n. T\u1ed5ng 30ml d\u1ecbch s\u1ebd \u0111\u01b0\u1ee3c \u0111\u01b0a qua \u1ed1ng th\u00f4ng r\u1ed3i th\u1ef1c hi\u1ec7n r\u1eeda \u1ed1ng theo h\u01b0\u1edbng d\u1eabn c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t \u1ed1ng th\u00f4ng. S\u1eed d\u1ee5ng d\u1ecbch ph\u00e2n t\u00e1n v\u00e0 r\u1eeda c\u1eb7n trong v\u00f2ng 30 ph\u00fat k\u1ec3 t\u1eeb khi pha.<\/p>\n<h2 style=\"text-align: justify;\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Tagrisso 80mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Kh\u00f4ng d\u00f9ng Tagrisso 80mg cho ng\u01b0\u1eddi c\u00f3 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Kh\u00f4ng d\u00f9ng k\u1ebft h\u1ee3p St John\u2019s Wort v\u1edbi Tagrisso v\u00ec l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 osimertinib.<\/p>\n<h2 style=\"text-align: justify;\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Tagrisso 80mg<\/h2>\n<h3 style=\"text-align: justify;\">Th\u1eadn tr\u1ecdng<\/h3>\n<p>Tr\u01b0\u1edbc khi d\u00f9ng Tagrisso c\u1ea7n x\u00e1c \u0111\u1ecbnh \u0111\u1ed9t bi\u1ebfn EGFR T790M b\u1eb1ng x\u00e9t nghi\u1ec7m \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn tr\u00ean m\u1eabu m\u00f4 kh\u1ed1i u ho\u1eb7c m\u1eabu huy\u1ebft t\u01b0\u01a1ng ctDNA. K\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh \u1edf m\u1eabu m\u00f4 ho\u1eb7c huy\u1ebft t\u01b0\u01a1ng \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n \u0111i\u1ec1u tr\u1ecb. N\u1ebfu x\u00e9t nghi\u1ec7m huy\u1ebft t\u01b0\u01a1ng \u00e2m t\u00ednh n\u00ean x\u00e9t nghi\u1ec7m m\u1eabu m\u00f4 n\u1ebfu c\u00f3 th\u1ec3 do nguy c\u01a1 \u00e2m t\u00ednh gi\u1ea3 c\u1ee7a<\/p>\n<p>Tagrisso 80mg c\u00f3 th\u1ec3 g\u00e2y b\u1ec7nh ph\u1ed5i m\u00f4 k\u1ebd n\u1eb7ng ho\u1eb7c t\u1eed vong. \u0110\u00e3 ghi nh\u1eadn b\u1ec7nh ph\u1ed5i m\u00f4 k\u1ebd \u1edf kho\u1ea3ng 3 \u0111\u1ebfn 4% b\u1ec7nh nh\u00e2n v\u00e0 t\u1eed vong \u1edf m\u1ed9t t\u1ef7 l\u1ec7 nh\u1ecf. T\u1ea7n su\u1ea5t c\u00f3 s\u1ef1 kh\u00e1c nhau theo v\u00f9ng d\u00e2n t\u1ed9c, v\u00ed d\u1ee5 t\u1ea7n su\u1ea5t cao h\u01a1n \u1edf m\u1ed9t s\u1ed1 nh\u00f3m ng\u01b0\u1eddi Nh\u1eadt. N\u1ebfu b\u1ec7nh nh\u00e2n kh\u1edfi ph\u00e1t tri\u1ec7u ch\u1ee9ng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh ho\u1eb7c tri\u1ec7u ch\u1ee9ng n\u1eb7ng l\u00ean kh\u00f4ng gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c n\u00ean t\u1ea1m ng\u01b0ng thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 k\u1ef9 \u0111\u1ec3 lo\u1ea1i tr\u1eeb b\u1ec7nh ph\u1ed5i m\u00f4 k\u1ebd. N\u1ebfu ch\u1ea9n \u0111o\u00e1n b\u1ec7nh ph\u1ed5i m\u00f4 k\u1ebd n\u00ean ng\u01b0ng v\u0129nh vi\u1ec5n Tagrisso v\u00e0 \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p.<\/p>\n<p>Tagrisso 80mg c\u00f3 th\u1ec3 k\u00e9o d\u00e0i kho\u1ea3ng QTc v\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp th\u1ea5t. Tr\u00e1nh d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng QT k\u00e9o d\u00e0i b\u1ea9m sinh khi c\u00f3 th\u1ec3. Theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 v\u00e0 \u0111i\u1ec7n gi\u1ea3i \u1edf b\u1ec7nh nh\u00e2n c\u00f3 suy tim sung huy\u1ebft, r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c bi\u1ebft g\u00e2y k\u00e9o d\u00e0i QTc. Ng\u01b0ng \u0111i\u1ec1u tr\u1ecb n\u1ebfu QTc &gt; 500ms tr\u00ean \u00edt nh\u1ea5t hai l\u1ea7n \u0111o t\u00e1ch bi\u1ec7t cho \u0111\u1ebfn khi QTc gi\u1ea3m v\u1ec1 m\u1ee9c an to\u00e0n, sau \u0111\u00f3 c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc d\u00f9ng l\u1ea1i \u1edf li\u1ec1u th\u1ea5p h\u01a1n theo h\u01b0\u1edbng d\u1eabn. Ng\u01b0ng v\u0129nh vi\u1ec5n n\u1ebfu c\u00f3 xo\u1eafn \u0111\u1ec9nh ho\u1eb7c nh\u1ecbp nhanh th\u1ea5t nghi\u00eam tr\u1ecdng.<\/p>\n<p>Tr\u00ean b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 tim ho\u1eb7c b\u1ec7nh n\u1ec1n \u1ea3nh h\u01b0\u1edfng LVEF n\u00ean c\u00e2n nh\u1eafc \u0111\u00e1nh gi\u00e1 LVEF khi b\u1eaft \u0111\u1ea7u v\u00e0 theo d\u00f5i trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. N\u1ebfu xu\u1ea5t hi\u1ec7n d\u1ea5u hi\u1ec7u ho\u1eb7c tri\u1ec7u ch\u1ee9ng tim n\u00ean \u0111\u00e1nh gi\u00e1 LVEF.<\/p>\n<p>N\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 d\u1ea5u hi\u1ec7u nghi ng\u1edd b\u1ec7nh m\u1eaft c\u1ea5p ho\u1eb7c tr\u1ea7m tr\u1ecdng h\u01a1n nh\u01b0 ch\u1ea3y n\u01b0\u1edbc m\u1eaft, nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng, m\u1edd ho\u1eb7c \u0111au m\u1eaft th\u00ec ph\u1ea3i kh\u00e1m b\u00e1c s\u0129 chuy\u00ean khoa m\u1eaft ngay l\u1eadp t\u1ee9c.<\/p>\n<h3 style=\"text-align: justify;\">T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: ti\u00eau ch\u1ea3y, ph\u00e1t ban, kh\u00f4 da, \u0111au c\u01a1 x\u01b0\u01a1ng, m\u1ec7t m\u1ecfi, bu\u1ed3n n\u00f4n, r\u1ee5ng m\u00f3ng, gi\u1ea3m b\u1ea1ch c\u1ea7u.<\/p>\n<p>\u00cdt g\u1eb7p: vi\u00eam ph\u1ed5i th\u1ec3 k\u1ebd ho\u1eb7c \u0111\u1ed9c t\u00ednh ph\u1ed5i, t\u0103ng men gan, k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: ph\u1ea3n \u1ee9ng tim m\u1ea1ch nghi\u00eam tr\u1ecdng, suy gan n\u1eb7ng, bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i nghi\u00eam tr\u1ecdng.<\/p>\n<h3 style=\"text-align: justify;\">T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Tr\u00e1nh ph\u1ed1i h\u1ee3p v\u1edbi ch\u1ea5t c\u1ea3m \u1ee9ng m\u1ea1nh CYP3A do l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 Tagrisso 80mg.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi ch\u1ea5t c\u1ea3m \u1ee9ng trung b\u00ecnh do c\u00f3 th\u1ec3 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 thu\u1ed1c.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c l\u00e0 c\u01a1 ch\u1ea5t BCRP c\u00f3 ch\u1ec9 s\u1ed1 \u0111i\u1ec1u tr\u1ecb h\u1eb9p do nguy c\u01a1 t\u0103ng \u0111\u1ed9c t\u00ednh.<\/p>\n<h3 style=\"text-align: justify;\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/p>\n<h3 style=\"text-align: justify;\">Kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p style=\"text-align: justify;\">Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3 style=\"text-align: justify;\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p style=\"text-align: justify;\">X\u1eed tr\u00ed : B\u00e1o ngay v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi.<\/p>\n<h3 style=\"text-align: justify;\">B\u1ea3o qu\u1ea3n<\/h3>\n<p style=\"text-align: justify;\">\u0110\u1ec3 thu\u1ed1c tr\u00e1nh xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<p style=\"text-align: justify;\">B\u1ea3o qu\u1ea3n thu\u1ed1c \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30 \u0111\u1ed9 C, tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp t\u1eeb m\u1eb7t tr\u1eddi.<\/p>\n<h2 style=\"text-align: justify;\">S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p style=\"text-align: justify;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n<ul>\n<li>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/ofev-150mg\/\">Ofev 150mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Catalent Germany Eberbach GmbH (C\u01a1 s\u1edf \u0111\u00f3ng g\u00f3i &amp; xu\u1ea5t x\u01b0\u1edfng: Boehringer Ingelheim Pharma GmbH &amp; Co. KG), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN3-183-19.<\/li>\n<li>Thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/bigefinib-250\/\">Bigefinib 250<\/a> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh g\u1eb7p t\u00ecnh tr\u1ea1ng ung th\u01b0 ph\u1ed5i lo\u1ea1i kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o nh\u1ecf, \u0111ang trong giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c \u0111\u00e3 sang giai \u0111o\u1ea1n di c\u0103n, c\u00f3 \u0111\u1ed9t bi\u1ebfn ho\u1ea1t h\u00f3a EGFR TK.<\/li>\n<\/ul>\n<h2 style=\"text-align: justify;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Cross, D. A., Ashton, S. E., Ghiorghiu, S., Eberlein, C., Nebhan, C. A., Spitzler, P. J., Orme, J. P., Finlay, M. R., Ward, R. A., Mellor, M. J., Hughes, G., Rahi, A., Jacobs, V. N., Red Brewer, M., Ichihara, E., Sun, J., Jin, H., Ballard, P., Al-Kadhimi, K., Rowlinson, R., \u2026 Pao, W. (2014). AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Truy c\u1eadp ng\u00e0y 18\/09\/2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24893891\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24893891\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tagrisso 80mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c di c\u0103n c\u00f3 \u0111\u1ed9t bi\u1ebfn EGFR T790M d\u01b0\u01a1ng t\u00ednh.<\/p>\n","protected":false},"author":1,"featured_media":139801,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-139799","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/139799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=139799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/139801"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=139799"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=139799"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=139799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}