{"id":139218,"date":"2025-09-16T12:47:58","date_gmt":"2025-09-16T05:47:58","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=139218"},"modified":"2025-09-16T12:49:06","modified_gmt":"2025-09-16T05:49:06","slug":"omeptul-20mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/omeptul-20mg\/","title":{"rendered":"Omeptul 20mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong><a href=\"https:\/\/vnras.com\/drug\/omeptul-20mg\/\">Omeptul 20mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Gracure Pharmaceuticals Ltd., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-12327-11.<\/strong><\/p>\n<h2>Omeptul 20mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Omeptul 20mg<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf b\u01a1m proton (Proton Pump Inhibitor &#8211; PPI), m\u1ed7i vi\u00ean nang ch\u1ee9a <strong>Omeprazole <\/strong>20mg (d\u01b0\u1edbi d\u1ea1ng c\u00e1c vi h\u1ea1t bao tan trong ru\u1ed9t).<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-12327-11<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/p>\n<figure id=\"attachment_139219\" aria-describedby=\"caption-attachment-139219\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-139219\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg.jpg\" alt=\"Omeptul 20mg \u0111i\u1ec1u tr\u1ecb tr\u00e0o ng\u01b0\u1ee3c d\u1ecbch d\u1ea1 d\u00e0y - th\u1ef1c qu\u1ea3n\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Omeptul-20mg-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-139219\" class=\"wp-caption-text\">Omeptul 20mg \u0111i\u1ec1u tr\u1ecb tr\u00e0o ng\u01b0\u1ee3c d\u1ecbch d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Omeptul 20mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Omeprazole l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t (prodrug), sau khi \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o m\u00e1u s\u1ebd t\u1eadp trung t\u1ea1i c\u00e1c t\u1ebf b\u00e0o th\u00e0nh c\u1ee7a d\u1ea1 d\u00e0y (parietal cells) \u2013 n\u01a1i s\u1ea3n xu\u1ea5t acid. Trong m\u00f4i tr\u01b0\u1eddng acid cao \u0111\u1ed9 c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh, Omeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng l\u00e0 sulfenamide. Ch\u1ea5t n\u00e0y sau \u0111\u00f3 li\u00ean k\u1ebft kh\u00f4ng thu\u1eadn ngh\u1ecbch v\u1edbi nh\u00f3m sulfhydryl (-SH) c\u1ee7a enzym H+\/K+-ATPase, hay c\u00f2n g\u1ecdi l\u00e0 b\u01a1m proton.<\/p>\n<p>Enzym n\u00e0y l\u00e0 kh\u00e2u cu\u1ed1i c\u00f9ng v\u00e0 quan tr\u1ecdng nh\u1ea5t trong qu\u00e1 tr\u00ecnh b\u00e0i ti\u1ebft acid hydrochloric (HCl) v\u00e0o l\u00f2ng d\u1ea1 d\u00e0y. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf v\u0129nh vi\u1ec5n b\u01a1m proton, Omeprazole ng\u0103n ch\u1eb7n hi\u1ec7u qu\u1ea3 c\u1ea3 s\u1ef1 ti\u1ebft acid c\u01a1 b\u1ea3n (l\u00fac \u0111\u00f3i) v\u00e0 khi \u0111\u01b0\u1ee3c k\u00edch th\u00edch (b\u1edfi th\u1ee9c \u0103n, histamine, gastrin). T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c k\u00e9o d\u00e0i cho \u0111\u1ebfn khi c\u00e1c b\u01a1m proton m\u1edbi \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p, th\u01b0\u1eddng l\u00e0 sau 24 gi\u1edd, gi\u00fap ki\u1ec3m so\u00e1t acid d\u1ea1 d\u00e0y su\u1ed1t c\u1ea3 ng\u00e0y ch\u1ec9 v\u1edbi m\u1ed9t li\u1ec1u duy nh\u1ea5t.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Omeprazole kh\u00f4ng b\u1ec1n trong m\u00f4i tr\u01b0\u1eddng acid, do \u0111\u00f3 thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t bao tan trong ru\u1ed9t \u0111\u1ec3 b\u1ea3o v\u1ec7 ho\u1ea1t ch\u1ea5t kh\u1ecfi s\u1ef1 ph\u00e1 h\u1ee7y c\u1ee7a d\u1ecbch v\u1ecb v\u00e0 ch\u1ec9 tan ra \u1edf m\u00f4i tr\u01b0\u1eddng ki\u1ec1m c\u1ee7a ru\u1ed9t non. Thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1-2 gi\u1edd.<\/p>\n<p>Ph\u00e2n b\u1ed1: Kho\u1ea3ng 97% Omeprazole li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n t\u1ea1i gan, ch\u1ee7 y\u1ebfu qua h\u1ec7 th\u1ed1ng enzyme cytochrome P450, c\u1ee5 th\u1ec3 l\u00e0 isoenzyme CYP2C19 v\u00e0 CYP3A4.<\/p>\n<p>Th\u1ea3i tr\u1eeb: C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (kho\u1ea3ng 80%) v\u00e0 m\u1ed9t ph\u1ea7n qua ph\u00e2n. M\u1eb7c d\u00f9 th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng ng\u1eafn (kho\u1ea3ng 1-2 gi\u1edd), t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ti\u1ebft acid l\u1ea1i k\u00e9o d\u00e0i do s\u1ef1 li\u00ean k\u1ebft kh\u00f4ng thu\u1eadn ngh\u1ecbch v\u1edbi b\u01a1m proton.<\/p>\n<h2>Thu\u1ed1c Omeptul 20mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n (GERD): \u0110i\u1ec1u tr\u1ecb vi\u00eam th\u1ef1c qu\u1ea3n do tr\u00e0o ng\u01b0\u1ee3c v\u00e0 ki\u1ec3m so\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 \u1ee3 n\u00f3ng, \u1ee3 chua.<\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng: \u0110i\u1ec1u tr\u1ecb v\u00e0 ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t lo\u00e9t d\u1ea1 d\u00e0y, lo\u00e9t t\u00e1 tr\u00e0ng.<\/p>\n<p>Ph\u1ed1i h\u1ee3p di\u1ec7t tr\u1eeb vi khu\u1ea9n <em>Helicobacter pylori<\/em> (H. pylori): L\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n quan tr\u1ecdng trong c\u00e1c ph\u00e1c \u0111\u1ed3 \u0111a kh\u00e1ng sinh \u0111\u1ec3 ti\u1ec7t tr\u1eeb <em>H. pylori<\/em>, nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng.<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger-Ellison: \u0110i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft acid b\u1ec7nh l\u00fd hi\u1ebfm g\u1eb7p do kh\u1ed1i u gastrinoma.<\/p>\n<p>Ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb lo\u00e9t do thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs): D\u00e0nh cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao c\u1ea7n s\u1eed d\u1ee5ng NSAIDs k\u00e9o d\u00e0i.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Omeptul 20mg<\/h2>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Omeptul 20mg<\/h3>\n<p>Li\u1ec1u d\u00f9ng d\u01b0\u1edbi \u0111\u00e2y ch\u1ec9 mang t\u00ednh tham kh\u1ea3o v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<ul>\n<li>Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n: 20mg, 1 l\u1ea7n\/ng\u00e0y, d\u00f9ng trong 4-8 tu\u1ea7n.<\/li>\n<li>Lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng: 20mg, 1 l\u1ea7n\/ng\u00e0y (c\u00f3 th\u1ec3 t\u0103ng l\u00ean 40mg trong tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng). Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb th\u01b0\u1eddng l\u00e0 4 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t t\u00e1 tr\u00e0ng v\u00e0 8 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t d\u1ea1 d\u00e0y.<\/li>\n<li>Di\u1ec7t tr\u1eeb H. pylori: Ph\u1ed1i h\u1ee3p trong ph\u00e1c \u0111\u1ed3 3 ho\u1eb7c 4 thu\u1ed1c, li\u1ec1u Omeprazole th\u01b0\u1eddng l\u00e0 20mg, 2 l\u1ea7n\/ng\u00e0y, d\u00f9ng trong 7-14 ng\u00e0y.<\/li>\n<li>H\u1ed9i ch\u1ee9ng Zollinger-Ellison: Li\u1ec1u kh\u1edfi \u0111\u1ea7u 60mg, 1 l\u1ea7n\/ng\u00e0y, li\u1ec1u sau \u0111\u00f3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u00f9y theo \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n, c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 120mg\/ng\u00e0y. Li\u1ec1u tr\u00ean 80mg n\u00ean \u0111\u01b0\u1ee3c chia l\u00e0m 2 l\u1ea7n.<\/li>\n<\/ul>\n<h3>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Omeptul 20mg<\/h3>\n<p>\u0110\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u1ed1i \u01b0u, c\u1ea7n tu\u00e2n th\u1ee7 nghi\u00eam ng\u1eb7t c\u00e1ch d\u00f9ng sau:<\/p>\n<ul>\n<li>Th\u1eddi \u0111i\u1ec3m: U\u1ed1ng thu\u1ed1c v\u00e0o l\u00fac \u0111\u00f3i, l\u00fd t\u01b0\u1edfng l\u00e0 30-60 ph\u00fat tr\u01b0\u1edbc b\u1eefa \u0103n s\u00e1ng. \u0110i\u1ec1u n\u00e0y \u0111\u1ea3m b\u1ea3o n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u \u0111\u1ea1t \u0111\u1ec9nh v\u00e0o th\u1eddi \u0111i\u1ec3m c\u00e1c b\u01a1m proton \u0111\u01b0\u1ee3c ho\u1ea1t h\u00f3a nhi\u1ec1u nh\u1ea5t sau m\u1ed9t \u0111\u00eam ngh\u1ec9 ng\u01a1i.<\/li>\n<li>Thao t\u00e1c: Ph\u1ea3i nu\u1ed1t nguy\u00ean vi\u00ean thu\u1ed1c v\u1edbi m\u1ed9t ly n\u01b0\u1edbc. Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng \u0111\u01b0\u1ee3c nhai, nghi\u1ec1n n\u00e1t hay m\u1edf vi\u00ean nang, v\u00ec h\u00e0nh \u0111\u1ed9ng n\u00e0y s\u1ebd ph\u00e1 v\u1ee1 l\u1edbp m\u00e0ng bao tan trong ru\u1ed9t, khi\u1ebfn ho\u1ea1t ch\u1ea5t b\u1ecb acid d\u1ea1 d\u00e0y ph\u00e1 h\u1ee7y v\u00e0 m\u1ea5t t\u00e1c d\u1ee5ng.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Omeptul 20mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi Omeprazole, c\u00e1c d\u1eabn xu\u1ea5t benzimidazole kh\u00e1c (esomeprazole, lansoprazole, pantoprazole) ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Nelfinavir (m\u1ed9t thu\u1ed1c \u0111i\u1ec1u tr\u1ecb HIV).<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Omeptul 20mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb, c\u1ea7n lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng lo\u00e9t d\u1ea1 d\u00e0y \u00e1c t\u00ednh v\u00ec Omeprazole c\u00f3 th\u1ec3 che l\u1ea5p tri\u1ec7u ch\u1ee9ng, g\u00e2y ch\u1eadm tr\u1ec5 trong ch\u1ea9n \u0111o\u00e1n. \u0110\u1eb7c bi\u1ec7t, vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c k\u00e9o d\u00e0i c\u1ea7n \u0111\u01b0\u1ee3c b\u00e1c s\u0129 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd do c\u00e1c nguy c\u01a1 ti\u1ec1m t\u00e0ng:<\/p>\n<ul>\n<li>T\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng: S\u1eed d\u1ee5ng PPI li\u1ec1u cao ho\u1eb7c trong th\u1eddi gian d\u00e0i (tr\u00ean 1 n\u0103m) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng h\u00f4ng, c\u1ed5 tay v\u00e0 c\u1ed9t s\u1ed1ng, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i ho\u1eb7c c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 lo\u00e3ng x\u01b0\u01a1ng kh\u00e1c. Theo c\u00e1c d\u1eef li\u1ec7u c\u1eadp nh\u1eadt, nh\u01b0 trong b\u00e0i t\u1ed5ng quan c\u1ee7a Eric Lespessailles v\u00e0 Hechmi Toumi (2022), c\u01a1 ch\u1ebf c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c gi\u1ea3m h\u1ea5p thu canxi do m\u00f4i tr\u01b0\u1eddng acid d\u1ea1 d\u00e0y b\u1ecb thay \u0111\u1ed5i. B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 lo\u00e3ng x\u01b0\u01a1ng c\u1ea7n \u0111\u01b0\u1ee3c b\u1ed5 sung \u0111\u1ee7 canxi v\u00e0 Vitamin D.<\/li>\n<li>Gi\u1ea3m h\u1ea5p thu Vitamin B12 v\u00e0 Magie: Vi\u1ec7c gi\u1ea3m acid d\u1ea1 d\u00e0y k\u00e9o d\u00e0i c\u1ea3n tr\u1edf s\u1ef1 gi\u1ea3i ph\u00f3ng Vitamin B12 t\u1eeb th\u1ee9c \u0103n, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn thi\u1ebfu h\u1ee5t B12. H\u1ea1 magie m\u00e1u c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng PPI k\u00e9o d\u00e0i, c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0 co c\u1ee9ng c\u01a1, lo\u1ea1n nh\u1ecbp tim.<\/li>\n<li>T\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 vi\u00eam ph\u1ed5i: Acid d\u1ea1 d\u00e0y l\u00e0 m\u1ed9t h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 t\u1ef1 nhi\u00ean. Vi\u1ec7c \u1ee9c ch\u1ebf acid c\u00f3 th\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi khu\u1ea9n ph\u00e1t tri\u1ec3n, l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ru\u1ed9t, \u0111\u1eb7c bi\u1ec7t l\u00e0 ti\u00eau ch\u1ea3y do <em>Clostridioides difficile<\/em>, v\u00e0 c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 vi\u00eam ph\u1ed5i c\u1ed9ng \u0111\u1ed3ng.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Ng\u1eafn h\u1ea1n (Th\u01b0\u1eddng g\u1eb7p): Nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, ti\u00eau ch\u1ea3y, t\u00e1o b\u00f3n, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111\u1ea7y h\u01a1i.<\/p>\n<p>D\u00e0i h\u1ea1n (Li\u00ean quan \u0111\u1ebfn s\u1eed d\u1ee5ng k\u00e9o d\u00e0i): C\u00e1c nguy c\u01a1 \u0111\u00e3 n\u00eau \u1edf m\u1ee5c Th\u1eadn tr\u1ecdng nh\u01b0 t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng, thi\u1ebfu h\u1ee5t vitamin v\u00e0 kho\u00e1ng ch\u1ea5t, nhi\u1ec5m khu\u1ea9n. C\u00e1c t\u00e1c d\u1ee5ng hi\u1ebfm g\u1eb7p kh\u00e1c c\u00f3 th\u1ec3 bao g\u1ed3m vi\u00eam th\u1eadn k\u1ebd, lupus ban \u0111\u1ecf da b\u00e1n c\u1ea5p.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Omeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan b\u1edfi CYP2C19. Do \u0111\u00f3, n\u00f3 c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c kh\u00e1c:<\/p>\n<ul>\n<li>Clopidogrel: T\u01b0\u01a1ng t\u00e1c n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng. Omeprazole \u1ee9c ch\u1ebf enzyme CYP2C19, ng\u0103n c\u1ea3n s\u1ef1 chuy\u1ec3n h\u00f3a Clopidogrel (m\u1ed9t ti\u1ec1n ch\u1ea5t) th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh. \u0110i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 hi\u1ec7u qu\u1ea3 ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u c\u1ee7a Clopidogrel, t\u0103ng nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>C\u00e1c thu\u1ed1c kh\u00e1c: Omeprazole c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Warfarin, Phenytoin, Diazepam. N\u00f3 c\u0169ng c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c c\u1ea7n m\u00f4i tr\u01b0\u1eddng acid \u0111\u1ec3 h\u00f2a tan nh\u01b0 Ketoconazole, Itraconazole v\u00e0 c\u00e1c thu\u1ed1c kh\u00e1ng virus (Atazanavir).<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: D\u00f9 c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng cho th\u1ea5y \u0111\u1ed9c t\u00ednh, d\u1eef li\u1ec7u tr\u00ean ng\u01b0\u1eddi c\u00f2n h\u1ea1n ch\u1ebf. Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c trong th\u1eddi k\u1ef3 mang thai, \u0111\u1eb7c bi\u1ec7t l\u00e0 3 th\u00e1ng \u0111\u1ea7u, tr\u1eeb khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Omeprazole c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c. N\u1ebfu g\u1eb7p ph\u1ea3i c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y, ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng n\u00ean l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 bao g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00f3ng m\u1eb7t, \u0111au b\u1ee5ng. Hi\u1ec7n kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. \u0110i\u1ec1u tr\u1ecb ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng. C\u1ea7n \u0111\u01b0a b\u1ec7nh nh\u00e2n \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C, tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp v\u00e0 \u0111\u1ec3 xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Omeptul 20mg<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/omeprazol-20-hv\/\">Omeprazol 20-HV <\/a>l\u00e0 s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1ea1i Vi\u1ec7t Nam (US Pharma USA), ch\u1ee9a ho\u1ea1t ch\u1ea5t Omeprazole 20mg, c\u00f3 c\u00f4ng d\u1ee5ng \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 c\u00e1c b\u1ec7nh l\u00fd do t\u0103ng ti\u1ebft acid d\u1ea1 d\u00e0y nh\u01b0 lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng v\u00e0 tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Eric Lespessailles, Hechmi Toumi. Proton Pump Inhibitors and Bone Health: An Update Narrative Review, truy c\u1eadp ng\u00e0y 16 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36142643\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36142643\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Omeptul 20mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Gracure Pharmaceuticals Ltd., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-12327-11, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n (GERD).<\/p>\n","protected":false},"author":1,"featured_media":139220,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-139218","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/139218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=139218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/139220"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=139218"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=139218"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=139218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}