{"id":138864,"date":"2025-09-15T11:47:07","date_gmt":"2025-09-15T04:47:07","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=138864"},"modified":"2025-11-27T16:32:09","modified_gmt":"2025-11-27T09:32:09","slug":"zapnex-10","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/zapnex-10\/","title":{"rendered":"Zapnex-10"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Zapnex-10 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110153324 (S\u0110K c\u0169: VD-27456-17)<\/strong><\/p>\n

Zapnex-10 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Trong m\u1ed7i vi\u00ean u\u1ed1ng Zapnex-10<\/strong> c\u00f3 ch\u1ee9a Olanzapin v\u1edbi h\u00e0m l\u01b0\u1ee3ng l\u00e0 10mg.<\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n

S\u0110K: 893110153324 (S\u0110K c\u0169: VD-27456-17)<\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n

Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n

H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n

\"Zapnex-10\"
M\u1eabu c\u0169 v\u00e0 m\u1eabu m\u1edbi Zapnex-10<\/figcaption><\/figure>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zapnex-10<\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n

Zapnex-10 ch\u1ee9a ho\u1ea1t ch\u1ea5t olanzapin \u2013 m\u1ed9t d\u1eabn ch\u1ea5t c\u1ee7a nh\u00f3m dibenzodiazepin. Thu\u1ed1c ph\u00e1t huy t\u00e1c d\u1ee5ng th\u00f4ng qua vi\u1ec7c ch\u1eb7n c\u00e1c th\u1ee5 th\u1ec3 serotonin typ 2 (5-HT2A, 5-HT2C), typ 3, typ 6 v\u00e0 c\u00e1c th\u1ee5 th\u1ec3 dopamin t\u1ea1i h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. Ngo\u00e0i ra, thu\u1ed1c c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u h\u00f2a \u00e2m t\u00ednh l\u00ean c\u00e1c th\u1ee5 th\u1ec3 5-HT2A, g\u00f3p ph\u1ea7n \u1ed5n \u0111\u1ecbnh kh\u00ed s\u1eafc v\u00e0 ch\u1ed1ng h\u01b0ng c\u1ea3m. Olanzapin c\u0169ng \u1ee9c ch\u1ebf nh\u1eb9 c\u00e1c th\u1ee5 th\u1ec3 dopamin D2 \u2013 y\u1ebfu t\u1ed1 g\u00f3p ph\u1ea7n v\u00e0o t\u00e1c d\u1ee5ng \u0111i\u1ec1u ch\u1ec9nh c\u1ea3m x\u00fac c\u1ee7a thu\u1ed1c.<\/p>\n

Zapnex-10 c\u0169ng \u0111\u1ed1i kh\u00e1ng v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 muscarinic (M1-M5), histamin H1 v\u00e0 alpha1-adrenergic, qua \u0111\u00f3 g\u00f3p ph\u1ea7n g\u00e2y an th\u1ea7n, ch\u1ed1ng bu\u1ed3n n\u00f4n v\u00e0 \u1ed5n \u0111\u1ecbnh huy\u1ebft \u00e1p.<\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

H\u1ea5p thu: Zapnex-10 h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u1edbi sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 60% do b\u1ecb chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u qua gan. Kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 hay m\u1ee9c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a thu\u1ed1c Zapnex-10 n\u1ebfu d\u00f9ng chung v\u1edbi th\u1ee9c \u0103n<\/p>\n

Ph\u00e2n b\u1ed1: Sau khi v\u00e0o c\u01a1 th\u1ec3, ho\u1ea1t ch\u1ea5t Olanzapin ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i trong m\u00f4 (Vd l\u1edbn ~1000 l\u00edt), \u0111\u1eb7c bi\u1ec7t l\u00e0 m\u00f4 th\u1ea7n kinh. Kho\u1ea3ng 93% ho\u1ea1t ch\u1ea5t n\u00e0y li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

Chuy\u1ec3n h\u00f3a: Olanzapin chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua gan nh\u1edd enzym CYP1A2 v\u00e0 qua CYP2D6 ch\u1ec9 v\u1edbi m\u1ed9t ph\u1ea7n nh\u1ecf, sau \u0111\u00f3 li\u00ean h\u1ee3p v\u1edbi acid glucuronic \u0111\u1ec3 t\u1ea1o ra c\u00e1c ch\u1ea5t kh\u00f4ng c\u00f2n ho\u1ea1t t\u00ednh.<\/p>\n

Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a thu\u1ed1c ~ 30 gi\u1edd, c\u00f3 th\u1ec3 k\u00e9o d\u00e0i h\u01a1n \u1edf ng\u01b0\u1eddi cao tu\u1ed5i. Thu\u1ed1c th\u1ea3i ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (57%) v\u00e0 ph\u00e2n (30%), ph\u1ea7n l\u1edbn \u1edf d\u1ea1ng \u0111\u00e3 chuy\u1ec3n h\u00f3a.<\/p>\n

Thu\u1ed1c Zapnex-10 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

\u0110i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, bao g\u1ed3m c\u1ea3 giai \u0111o\u1ea1n c\u1ea5p t\u00ednh v\u00e0 duy tr\u00ec sau khi \u0111\u00e3 \u0111\u1ea1t \u0111\u00e1p \u1ee9ng ban \u0111\u1ea7u.<\/p>\n

Ki\u1ec3m so\u00e1t v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c \u0111\u1ee3t h\u01b0ng c\u1ea3m v\u1eeba ho\u1eb7c n\u1eb7ng trong r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/p>\n

D\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t h\u01b0ng c\u1ea3m \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c \u0111\u00e3 t\u1eebng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi olanzapin tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n

Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n

Li\u1ec1u d\u00f9ng<\/h3>\n

Ng\u01b0\u1eddi l\u1edbn<\/strong><\/em><\/p>\n

T\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t:<\/strong><\/span><\/p>\n

B\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u 5\u201310 mg\/ng\u00e0y, u\u1ed1ng 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

C\u00f3 th\u1ec3 t\u0103ng li\u1ec1u 5 mg sau m\u1ed7i 5\u20137 ng\u00e0y t\u00f9y \u0111\u00e1p \u1ee9ng, li\u1ec1u t\u1ed1i \u0111a kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 20 mg\/ng\u00e0y.<\/p>\n

Li\u1ec1u duy tr\u00ec th\u01b0\u1eddng t\u1eeb 10\u201320 mg\/ng\u00e0y.<\/p>\n

R\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c (h\u01b0ng c\u1ea3m ho\u1eb7c h\u1ed7n h\u1ee3p):<\/strong><\/span><\/p>\n

\u0110\u01a1n tr\u1ecb li\u1ec7u: Li\u1ec1u kh\u1edfi \u0111\u1ea7u 10\u201315 mg\/ng\u00e0y.<\/p>\n

C\u00f3 th\u1ec3 t\u0103ng th\u00eam 5 mg\/ng\u00e0y n\u1ebfu c\u1ea7n, c\u00e1ch nhau \u00edt nh\u1ea5t 24 gi\u1edd.<\/p>\n

Li\u1ec1u t\u1ed1i \u0111a 20 mg\/ng\u00e0y.<\/p>\n

K\u1ebft h\u1ee3p v\u1edbi lithium ho\u1eb7c valproat: Li\u1ec1u t\u01b0\u01a1ng t\u1ef1 \u0111\u01a1n tr\u1ecb li\u1ec7u (10\u201315 mg\/ng\u00e0y), hi\u1ec7u ch\u1ec9nh trong kho\u1ea3ng 5\u201320 mg\/ng\u00e0y.<\/p>\n

Ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t:<\/strong> <\/span>Duy tr\u00ec li\u1ec1u 5\u201320 mg\/ng\u00e0y t\u00f9y theo li\u1ec1u \u0111\u00e3 d\u00f9ng trong giai \u0111o\u1ea1n c\u1ea5p.<\/p>\n

Tr\u1ebb em (13\u201317 tu\u1ed5i)<\/strong><\/em><\/p>\n

T\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u00e0 r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c 1\/4-1\/2 li\u1ec1u Zapnex 10 (n\u00ean \u0111\u1ed5i ch\u1ebf ph\u1ea9m c\u00f3 h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p), t\u1ed1i \u0111a: 4 vi\u00ean Zapnex 10 m\u1ed7i ng\u00e0y.<\/p>\n

\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/strong><\/em><\/p>\n

Ng\u01b0\u1eddi cao tu\u1ed5i\/suy gan\/th\u1eadn C\u00f3 th\u1ec3 c\u00e2n nh\u1eafc kh\u1edfi \u0111\u1ea7u v\u1edbi ch\u1ebf ph\u1ea9m c\u00f3 h\u00e0m l\u01b0\u1ee3ng 5mg n\u1ebfu l\u00e2m s\u00e0ng ph\u00f9 h\u1ee3p.<\/p>\n

Ng\u01b0\u1eddi h\u00fat thu\u1ed1c l\u00e1: C\u00f3 th\u1ec3 t\u0103ng t\u1ed1c \u0111\u1ed9 chuy\u1ec3n h\u00f3a thu\u1ed1c, c\u1ea7n theo d\u00f5i v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u n\u1ebfu c\u1ea7n.<\/p>\n

C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n

D\u00f9ng vi\u00ean n\u00e9n Zapnex-10<\/strong> b\u1eb1ng c\u00e1ch u\u1ed1ng nhi\u1ec1u v\u1edbi n\u01b0\u1edbc, c\u00f3 th\u1ec3 d\u00f9ng k\u00e8m ho\u1eb7c kh\u00f4ng k\u00e8m b\u1eefa \u0103n.<\/p>\n

V\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 bu\u1ed3n ng\u1ee7 k\u00e9o d\u00e0i, n\u00ean d\u00f9ng v\u00e0o bu\u1ed5i t\u1ed1i \u0111\u1ec3 gi\u1ea3m \u1ea3nh h\u01b0\u1edfng t\u1edbi sinh ho\u1ea1t ban ng\u00e0y.<\/p>\n

N\u00ean hi\u1ec7u ch\u1ec9nh li\u1ec1u t\u1eeb t\u1eeb, t\u0103ng d\u1ea7n theo \u0111\u00e1p \u1ee9ng v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh.<\/p>\n

Khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb, c\u1ea7n gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb \u0111\u1ec3 tr\u00e1nh t\u00e1c d\u1ee5ng ph\u1ee5 do ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t.<\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Zapnex-10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n

Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng v\u1edbi olanzapin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u00f3 trong ch\u1ebf ph\u1ea9m.<\/p>\n

Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa<\/p>\n

B\u1ec7nh nh\u00e2n t\u0103ng nh\u00e3n \u00e1p g\u00f3c \u0111\u00f3ng hay c\u00f3 nguy c\u01a1 cao m\u1eafc b\u1ec7nh n\u00e0y<\/p>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n

Th\u1eadn tr\u1ecdng<\/h3>\n

C\u00f3 th\u1ec3 m\u1ea5t nhi\u1ec1u ng\u00e0y \u0111\u1ebfn v\u00e0i tu\u1ea7n \u0111\u1ec3 c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng, c\u1ea7n theo d\u00f5i s\u00e1t trong th\u1eddi gian \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n

B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 t\u1ef1 s\u00e1t c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i k\u1ef9 trong su\u1ed1t qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c.<\/p>\n

B\u1ec7nh nh\u00e2n sa s\u00fat tr\u00ed tu\u1ec7 c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 t\u1eed vong khi d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

Kh\u00f4ng khuy\u1ebfn kh\u00edch d\u00f9ng cho ng\u01b0\u1eddi Parkinson do c\u00f3 th\u1ec3 l\u00e0m n\u1eb7ng th\u00eam tri\u1ec7u ch\u1ee9ng.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y h\u1ed9i ch\u1ee9ng an th\u1ea7n kinh \u00e1c t\u00ednh; n\u1ebfu c\u00f3 s\u1ed1t cao, lo\u1ea1n th\u1ea7n kinh th\u1ef1c v\u1eadt th\u00ec ph\u1ea3i ng\u1eebng thu\u1ed1c ngay.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, k\u1ec3 c\u1ea3 sau khi ng\u1eebng thu\u1ed1c. C\u1ea7n theo d\u00f5i \u0111\u01b0\u1eddng huy\u1ebft \u1edf ng\u01b0\u1eddi c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1.<\/p>\n

C\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i m\u1ee1 m\u00e1u; c\u1ea7n theo d\u00f5i th\u01b0\u1eddng xuy\u00ean, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi c\u00f3 r\u1ed1i lo\u1ea1n lipid ho\u1eb7c y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y t\u0103ng c\u00e2n r\u00f5 r\u1ec7t; c\u1ea7n theo d\u00f5i c\u00e2n n\u1eb7ng \u0111\u1ec1u \u0111\u1eb7n.<\/p>\n

T\u00e1c d\u1ee5ng kh\u00e1ng cholinergic c\u00f3 th\u1ec3 g\u00e2y kh\u00f3 ti\u1ec3u, t\u00e1o b\u00f3n, t\u0103ng nh\u00e3n \u00e1p… th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi c\u00f3 b\u1ec7nh n\u1ec1n li\u00ean quan.<\/p>\n

N\u1ebfu c\u00f3 b\u1ea5t th\u01b0\u1eddng gan ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c g\u00e2y \u0111\u1ed9c gan, c\u1ea7n theo d\u00f5i men gan \u0111\u1ecbnh k\u1ef3.<\/p>\n

C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m b\u1ea1ch c\u1ea7u, nh\u1ea5t l\u00e0 khi d\u00f9ng c\u00f9ng valproat ho\u1eb7c \u1edf ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed suy t\u1ee7y x\u01b0\u01a1ng.<\/p>\n

Ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 g\u00e2y run, m\u1ea5t ng\u1ee7, lo l\u1eafng, bu\u1ed3n n\u00f4n… n\u00ean gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y k\u00e9o d\u00e0i QT, n\u00ean c\u1ea9n tr\u1ecdng khi d\u00f9ng chung thu\u1ed1c l\u00e0m t\u0103ng nguy c\u01a1 n\u00e0y ho\u1eb7c \u1edf b\u1ec7nh nh\u00e2n tim m\u1ea1ch.<\/p>\n

Nguy c\u01a1 huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi \u00edt v\u1eadn \u0111\u1ed9ng, c\u1ea7n \u0111\u00e1nh gi\u00e1 y\u1ebfu t\u1ed1 nguy c\u01a1.<\/p>\n

G\u00e2y bu\u1ed3n ng\u1ee7, gi\u1ea3m t\u1eadp trung; tr\u00e1nh d\u00f9ng v\u1edbi r\u01b0\u1ee3u hay thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y co gi\u1eadt, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9ng kinh ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng \u0111\u1ea7u.<\/p>\n

D\u1ec5 g\u00e2y r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng mu\u1ed9n, \u0111\u1eb7c bi\u1ec7t \u1edf ph\u1ee5 n\u1eef l\u1edbn tu\u1ed5i; n\u1ebfu x\u1ea3y ra c\u1ea7n xem x\u00e9t ng\u01b0ng thu\u1ed1c.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi b\u1ec7nh tim, m\u1ea5t n\u01b0\u1edbc, ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c h\u1ea1 \u00e1p.<\/p>\n

\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 \u0111\u1ed9t t\u1eed li\u00ean quan \u0111\u1ebfn tim khi d\u00f9ng thu\u1ed1c.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y h\u1ed9i ch\u1ee9ng DRESS (ph\u00e1t ban, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, s\u1ed1t…), n\u1ebfu nghi ng\u1edd ph\u1ea3i ng\u01b0ng thu\u1ed1c ngay.<\/p>\n

C\u00f3 th\u1ec3 g\u00e2y kh\u00f3 nu\u1ed1t, s\u1eb7c, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi gi\u00e0 b\u1ecb sa s\u00fat tr\u00ed tu\u1ec7.<\/p>\n

C\u1ea7n \u0111\u1ec1 ph\u00f2ng t\u0103ng th\u00e2n nhi\u1ec7t khi d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi m\u1ea5t n\u01b0\u1edbc, v\u1eadn \u0111\u1ed9ng nhi\u1ec1u, ho\u1eb7c d\u00f9ng thu\u1ed1c kh\u00e1ng cholinergic.<\/p>\n

T\u0103ng prolactin m\u00e1u c\u00f3 th\u1ec3 x\u1ea3y ra khi d\u00f9ng k\u00e9o d\u00e0i.<\/p>\n

Kh\u00f4ng d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 13 tu\u1ed5i; \u1edf l\u1ee9a tu\u1ed5i 13\u201317 c\u1ea7n theo d\u00f5i ch\u1eb7t do nguy c\u01a1 t\u0103ng c\u00e2n, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a.<\/p>\n

Thu\u1ed1c c\u00f3 ch\u1ee9a lactose, m\u00e0u t\u1ed5ng h\u1ee3p v\u00e0 t\u00e1 d\u01b0\u1ee3c d\u1ec5 g\u00e2y d\u1ecb \u1ee9ng ho\u1eb7c r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a \u1edf ng\u01b0\u1eddi m\u1eabn c\u1ea3m.<\/p>\n

T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n\n\n\n\n\n\n\n\n\n\n
T\u1ea7n su\u1ea5t<\/strong><\/td>\nPh\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i<\/strong><\/td>\n<\/tr>\n
R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/strong>
\n(\u2265 1\/10)<\/strong><\/td>\n		T\u0103ng c\u00e2n
\nBu\u1ed3n ng\u1ee7
\nT\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf
\nT\u0103ng prolactin m\u00e1u<\/td>\n<\/tr>\n
Th\u01b0\u1eddng g\u1eb7p<\/strong>
\n(\u2265 1\/100 \u0111\u1ebfn < 1\/10)<\/strong><\/td>\n		T\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh
\nT\u0103ng cholesterol, glucose, triglycerid, ti\u1ec3u \u0111\u01b0\u1eddng ni\u1ec7u
\nC\u1ea3m gi\u00e1c th\u00e8m \u0103n t\u0103ng
\nHoa m\u1eaft, b\u1ed3n ch\u1ed3n, h\u1ed9i ch\u1ee9ng Parkinson, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng
\nT\u00e1o b\u00f3n, kh\u00f4 mi\u1ec7ng
\nT\u0103ng men gan (ALT, AST) nh\u1eb9, tho\u00e1ng qua
\nPh\u00e1t ban da
\n\u0110au kh\u1edbp
\nR\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng, gi\u1ea3m ham mu\u1ed1n t\u00ecnh d\u1ee5c
\nSuy nh\u01b0\u1ee3c, m\u1ec7t, ph\u00f9 n\u1ec1, s\u1ed1t
\nT\u0103ng phosphatase ki\u1ec1m, CK, GGT, acid uric<\/td>\n<\/tr>\n
\u00cdt g\u1eb7p<\/strong>
\n(\u2265 1\/1.000 \u0111\u1ebfn < 1\/100)<\/strong><\/td>\n		Qu\u00e1 m\u1eabn
\nT\u0103ng \u0111\u01b0\u1eddng huy\u1ebft c\u00f3 th\u1ec3 k\u00e8m toan ceton ho\u1eb7c h\u00f4n m\u00ea
\nCo gi\u1eadt, lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c, lo\u1ea1n v\u1eadn ng\u00f4n, m\u1ea5t tr\u00ed nh\u1edb, v\u1eadn \u0111\u1ed9ng mu\u1ed9n
\nNh\u1ecbp tim ch\u1eadm, k\u00e9o d\u00e0i QT, huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u ho\u1eb7c ph\u1ed5i
\nCh\u1ea3y m\u00e1u m\u0169i
\n\u0110\u1ea7y b\u1ee5ng
\nD\u1ecb \u1ee9ng \u00e1nh s\u00e1ng, r\u1ee5ng t\u00f3c
\nB\u00ed ti\u1ec3u, ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7
\nV\u00fa to, ti\u1ebft s\u1eefa, n\u1eef h\u00f3a tuy\u1ebfn v\u00fa
\nT\u0103ng bilirubin to\u00e0n ph\u1ea7n<\/td>\n<\/tr>\n
Hi\u1ebfm g\u1eb7p<\/strong>
\n(\u2265 1\/10.000 \u0111\u1ebfn < 1\/1.000)<\/strong><\/td>\n		Gi\u1ea3m ti\u1ec3u c\u1ea7u
\nH\u1ea1 th\u00e2n nhi\u1ec7t
\nH\u1ed9i ch\u1ee9ng an th\u1ea7n kinh \u00e1c t\u00ednh, tri\u1ec7u ch\u1ee9ng cai thu\u1ed1c
\nLo\u1ea1n nh\u1ecbp th\u1ea5t, ng\u1eebng tim, t\u1eed vong
\nVi\u00eam t\u1ee5y
\nVi\u00eam gan \u1edf nhi\u1ec1u th\u1ec3 (t\u1ebf b\u00e0o, \u1ee9 m\u1eadt ho\u1eb7c ph\u1ed1i h\u1ee3p)
\nTi\u00eau c\u01a1 v\u00e2n
\nC\u01b0\u01a1ng c\u1ee9ng k\u00e9o d\u00e0i<\/td>\n<\/tr>\n
Ch\u01b0a r\u00f5 t\u1ea7n su\u1ea5t<\/strong><\/td>\nH\u1ed9i ch\u1ee9ng cai thu\u1ed1c \u1edf tr\u1ebb s\u01a1 sinh
\nDRESS: ph\u1ea3n \u1ee9ng da, s\u1ed1t, n\u1ed5i h\u1ea1ch, k\u00e8m t\u1ed5n th\u01b0\u01a1ng c\u01a1 quan n\u1ed9i t\u1ea1ng (gan, th\u1eadn, ph\u1ed5i, tim, c\u01a1…)<\/td>\n<\/tr>\n
\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/strong><\/td>\nNg\u01b0\u1eddi cao tu\u1ed5i sa s\u00fat tr\u00ed tu\u1ec7: t\u0103ng nguy c\u01a1 t\u1eed vong, vi\u00eam ph\u1ed5i, ng\u00e3, ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7, \u1ea3o gi\u00e1c
\nB\u1ec7nh nh\u00e2n Parkinson: tri\u1ec7u ch\u1ee9ng v\u1eadn \u0111\u1ed9ng v\u00e0 \u1ea3o gi\u00e1c n\u1eb7ng h\u01a1n
\nPh\u1ed1i h\u1ee3p valproat\/lithi: t\u0103ng nguy c\u01a1 gi\u1ea3m b\u1ea1ch c\u1ea7u, run, kh\u00f4 mi\u1ec7ng, t\u0103ng c\u00e2n
\nS\u1eed d\u1ee5ng \u2265 12 tu\u1ea7n: t\u0103ng c\u00e2n \u0111\u00e1ng k\u1ec3, thay \u0111\u1ed5i chuy\u1ec3n h\u00f3a<\/td>\n<\/tr>\n
Tr\u1ebb em (13\u201317 tu\u1ed5i)<\/strong><\/td>\nR\u1ea5t th\u01b0\u1eddng g\u1eb7p: t\u0103ng c\u00e2n, t\u0103ng triglycerid, \u0103n ngon, bu\u1ed3n ng\u1ee7, t\u0103ng men gan, t\u0103ng prolactin
\nTh\u01b0\u1eddng g\u1eb7p: t\u0103ng cholesterol, kh\u00f4 mi\u1ec7ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u01b0\u01a1ng t\u00e1c<\/h3>\n

Tr\u00e1nh d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi levomethadyl do nguy c\u01a1 g\u00e2y r\u1ed1i lo\u1ea1n nh\u1ecbp tim nghi\u00eam tr\u1ecdng nh\u01b0 xo\u1eafn \u0111\u1ec9nh, ho\u1eb7c metoclopramid v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng g\u1eb7p t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn th\u1ea7n kinh nh\u01b0 c\u1ee9ng \u0111\u1edd c\u01a1, r\u1ed1i lo\u1ea1n tri gi\u00e1c.<\/p>\n

Khi d\u00f9ng c\u00f9ng diazepam, c\u00f3 th\u1ec3 g\u00e2y t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng; c\u1ea7n theo d\u00f5i s\u00e1t.<\/p>\n

C\u00e1c ch\u1ea5t l\u00e0m t\u0103ng chuy\u1ec3n h\u00f3a qua CYP1A2 nh\u01b0 nicotin, carbamazepin, phenobarbital, rifampicin\u2026 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u1ee7a thu\u1ed1c trong m\u00e1u, d\u1eabn t\u1edbi hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb gi\u1ea3m.<\/p>\n

Fluvoxamin v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP1A2 (v\u00ed d\u1ee5 ciprofloxacin, erythromycin, quinidin) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u; n\u00ean b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u th\u1ea5p n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n

Than ho\u1ea1t t\u00ednh l\u00e0m gi\u1ea3m h\u1ea5p thu thu\u1ed1c n\u1ebfu d\u00f9ng g\u1ea7n th\u1eddi \u0111i\u1ec3m u\u1ed1ng thu\u1ed1c; n\u00ean d\u00f9ng c\u00e1ch nhau \u00edt nh\u1ea5t 2 gi\u1edd.<\/p>\n

Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c gi\u1ed1ng giao c\u1ea3m nh\u01b0 adrenalin ho\u1eb7c dopamin v\u00ec c\u00f3 th\u1ec3 g\u00e2y t\u1ee5t huy\u1ebft \u00e1p do t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c.<\/p>\n

C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c t\u0103ng ho\u1ea1t dopamin nh\u01b0 levodopa.<\/p>\n

C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng an th\u1ea7n, kh\u00f4 mi\u1ec7ng, t\u00e1o b\u00f3n ho\u1eb7c b\u00ed ti\u1ec3u khi d\u00f9ng chung v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng cholinergic.<\/p>\n

L\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p khi d\u00f9ng chung v\u1edbi thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/p>\n

Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP450 nh\u01b0 warfarin, theophyllin, diazepam, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng.<\/p>\n

Kh\u00f4ng l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 valproat trong m\u00e1u khi d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n

C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi r\u01b0\u1ee3u ho\u1eb7c thu\u1ed1c an th\u1ea7n kh\u00e1c do t\u0103ng t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n

H\u1ea1n ch\u1ebf d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u0111i\u1ec1u tr\u1ecb Parkinson \u1edf ng\u01b0\u1eddi b\u1ec7nh Parkinson c\u00f3 sa s\u00fat tr\u00ed tu\u1ec7.<\/p>\n

C\u1ea7n c\u00e2n nh\u1eafc khi d\u00f9ng chung v\u1edbi thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng k\u00e9o d\u00e0i kho\u1ea3ng QT v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp tim.<\/p>\n

L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n

Hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u c\u00f3 ki\u1ec3m so\u00e1t tr\u00ean ng\u01b0\u1eddi mang thai. N\u1ebfu c\u00f3 thai ho\u1eb7c d\u1ef1 \u0111\u1ecbnh mang thai trong khi \u0111ang d\u00f9ng thu\u1ed1c, b\u1ec7nh nh\u00e2n c\u1ea7n b\u00e1o v\u1edbi b\u00e1c s\u0129 \u0111\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 nguy c\u01a1\u2013l\u1ee3i \u00edch.<\/p>\n

Tr\u1ebb s\u01a1 sinh ti\u1ebfp x\u00fac v\u1edbi thu\u1ed1c trong giai \u0111o\u1ea1n cu\u1ed1i thai k\u1ef3 c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i c\u00e1c d\u1ea5u hi\u1ec7u nh\u01b0 c\u1ee9ng c\u01a1, run, m\u1ec7t m\u1ecfi, r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1edf ho\u1eb7c b\u00fa k\u00e9m. Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i s\u00e1t sau sinh.<\/p>\n

Thu\u1ed1c b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1edf tr\u1ebb b\u00fa m\u1eb9 \u01b0\u1edbc t\u00ednh kho\u1ea3ng 1,8% li\u1ec1u d\u00f9ng c\u1ee7a m\u1eb9. Kh\u00f4ng n\u00ean cho con b\u00fa trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 tr\u00e1nh nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb.<\/p>\n

Ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng tin v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c l\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n

L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n

Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t v\u00e0 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ph\u1ea3n x\u1ea1; do \u0111\u00f3 ng\u01b0\u1eddi \u0111ang l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ho\u1eb7c l\u00e0m vi\u1ec7c \u1edf v\u1ecb tr\u00ed nguy hi\u1ec3m c\u1ea7n th\u1eadn tr\u1ecdng ho\u1eb7c tr\u00e1nh s\u1eed d\u1ee5ng thu\u1ed1c trong th\u1eddi gian n\u00e0y.<\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n

Tri\u1ec7u ch\u1ee9ng khi qu\u00e1 li\u1ec1u<\/strong><\/em><\/p>\n

Th\u01b0\u1eddng g\u1eb7p: Nh\u1ecbp tim nhanh, k\u00edch \u0111\u1ed9ng, n\u00f3i kh\u00f4ng r\u00f5, c\u00e1c d\u1ea5u hi\u1ec7u ngo\u1ea1i th\u00e1p, l\u01a1 m\u01a1 ho\u1eb7c h\u00f4n m\u00ea.<\/p>\n

Tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng: Co gi\u1eadt, h\u1ea1 ho\u1eb7c t\u0103ng huy\u1ebft \u00e1p, lo\u1ea1n nh\u1ecbp tim, m\u00ea s\u1ea3ng, suy h\u00f4 h\u1ea5p, s\u1eb7c, c\u00f3 th\u1ec3 ng\u01b0ng tim.<\/p>\n

\u0110\u00e3 c\u00f3 ca t\u1eed vong v\u1edbi li\u1ec1u kho\u1ea3ng 450 mg, nh\u01b0ng c\u0169ng c\u00f3 tr\u01b0\u1eddng h\u1ee3p s\u1ed1ng s\u00f3t sau khi d\u00f9ng t\u1edbi 2.000 mg \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n

X\u1eed tr\u00ed<\/strong><\/em><\/p>\n

Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c Zapnex-10 \u0111\u1eb7c hi\u1ec7u.<\/p>\n

Kh\u00f4ng n\u00ean g\u00e2y n\u00f4n. C\u00f3 th\u1ec3 r\u1eeda d\u1ea1 d\u00e0y ho\u1eb7c d\u00f9ng than ho\u1ea1t t\u00ednh n\u1ebfu trong th\u1eddi gian ng\u1eafn sau khi u\u1ed1ng.<\/p>\n

\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng, duy tr\u00ec ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p \u2013 tu\u1ea7n ho\u00e0n.<\/p>\n

Tr\u00e1nh d\u00f9ng c\u00e1c thu\u1ed1c nh\u01b0 epinephrin ho\u1eb7c dopamin do nguy c\u01a1 l\u00e0m n\u1eb7ng th\u00eam t\u1ee5t huy\u1ebft \u00e1p.<\/p>\n

C\u1ea7n theo d\u00f5i tim m\u1ea1ch ch\u1eb7t ch\u1ebd \u0111\u1ec3 ph\u00e1t hi\u1ec7n r\u1ed1i lo\u1ea1n nh\u1ecbp tim.<\/p>\n

Theo d\u00f5i b\u1ec7nh nh\u00e2n s\u00e1t cho \u0111\u1ebfn khi \u1ed5n \u0111\u1ecbnh ho\u00e0n to\u00e0n.<\/p>\n

B\u1ea3o qu\u1ea3n<\/h3>\n

Gi\u1eef Zapnex-10 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (<30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n

Kh\u00f4ng \u0111\u1ec3 Zapnex-10 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng Zapnex-10 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n

S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n

Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Zapnex-10 nh\u01b0:<\/p>\n

Zapnex-5<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Olanzapine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 5mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c<\/p>\n

A.T Olanzapine ODT 10mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Olanzapine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 10mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m An Thi\u00ean, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c<\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
    \n
  1. T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Zapnex-10 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 15 th\u00e1ng 9 n\u0103m 2025<\/li>\n
  2. Kolli P, Kelley G, Rosales M, Faden J, Serdenes R (2023). Olanzapine Pharmacokinetics: A Clinical Review of Current Insights and Remaining Questions. Pharmgenomics Pers Med. Truy c\u1eadp ng\u00e0y 15 th\u00e1ng 9 n\u0103m 2025 t\u1eeb: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10749543\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Thu\u1ed1c Zapnex-10 l\u00e0 thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n kh\u00f4ng \u0111i\u1ec3n h\u00ecnh, ch\u1ee9a olanzapin, th\u01b0\u1eddng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u00e0 c\u00e1c giai \u0111o\u1ea1n h\u01b0ng c\u1ea3m c\u1ee7a r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c.<\/p>\n","protected":false},"author":1,"featured_media":149379,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-138864","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/138864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=138864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/149379"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=138864"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=138864"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=138864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}