{"id":137999,"date":"2025-09-10T15:44:43","date_gmt":"2025-09-10T08:44:43","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=137999"},"modified":"2025-09-10T15:46:25","modified_gmt":"2025-09-10T08:46:25","slug":"acenocoumarol-1","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/acenocoumarol-1\/","title":{"rendered":"Acenocoumarol 1"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m Acenocoumarol 1<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n S.P.M, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110042500.<\/strong><\/p>\n

Thu\u1ed1c Acenocoumarol l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n
Thu\u1ed1c Acenocoumarol 1mg l\u00e0 thu\u1ed1c g\u00ec?<\/b> Thu\u1ed1c Acenocoumarol 1mg thu\u1ed1c kh\u00e1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u ph\u1ee5 thu\u1ed9c vitamin K. Nh\u1edd c\u01a1 ch\u1ebf n\u00e0y, thu\u1ed1c gi\u00fap h\u1ea1n ch\u1ebf h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i, h\u1ed7 tr\u1ee3 ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c bi\u1ebfn ch\u1ee9ng t\u1eafc m\u1ea1ch, th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho b\u1ec7nh nh\u00e2n tim m\u1ea1ch ho\u1eb7c sau ph\u1eabu thu\u1eadt thay van tim.<\/span><\/p>\n
$\"Thu\u1ed1c$ Thu\u1ed1c Acenocoumarol 1 \u0111i\u1ec1u tr\u1ecb v\u00e0 ph\u00f2ng ng\u1eeba b\u1ec7nh ngh\u1ebdn m\u1ea1ch<\/figcaption><\/figure>\n
Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n
Trong m\u1ed7i vi\u00ean <\/span>Acenocoumarol 1<\/b> c\u00f3 ch\u1ee9a:<\/span><\/p>\n
Acenocoumarol\u2026\u2026\u2026\u2026\u2026\u2026\u2026 1mg.<\/span><\/p>\n
T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 m\u1ed9t vi\u00ean n\u00e9n.<\/span><\/p>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n.<\/span><\/p>\n
Tr\u00ecnh b\u00e0y<\/span><\/h3>\n
S\u0110K: 893110042500 (S\u0110K c\u0169: VD-22293-15)<\/span><\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n
Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam \u2013 C\u00f4ng ty C\u1ed5 ph\u1ea7n S.P.M<\/span><\/p>\n
H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t\u00a0<\/span><\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Acenocoumarol<\/span><\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Acenocoumarol<\/span><\/h3>\n
Acenocoumarol 1 l\u00e0 thu\u1ed1c kh\u00e1ng \u0111\u00f4ng nh\u00f3m vitamin K (Vitamin K antagonist), \u1ee9c ch\u1ebf enzyme vitamin K epoxide reductase (VKORC1), l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng t\u00e1i t\u1ea1o d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a vitamin K. K\u1ebft qu\u1ea3 l\u00e0, c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u ph\u1ee5 thu\u1ed9c vitamin K (h\u1ec7 s\u1ed1 II, VII, IX v\u00e0 X) b\u1ecb gi\u1ea3m carboxyl h\u00f3a v\u00e0 kh\u00f4ng th\u1ec3 ho\u1ea1t h\u00f3a \u0111\u1ec3 tham gia qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u hi\u1ec7u qu\u1ea3. \u0110i\u1ec1u n\u00e0y l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh t\u1ea1o c\u1ee5c m\u00e1u \u0111\u00f4ng t\u1eeb c\u1ea3 hai con \u0111\u01b0\u1eddng \u0111\u00f4ng m\u00e1u n\u1ed9i sinh v\u00e0 ngo\u1ea1i sinh.<\/span><\/p>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/span><\/h3>\n
H\u1ea5p thu<\/span><\/h4>\n
Acenocoumarol 1 \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng u\u1ed1ng v\u1edbi sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng >60%. N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng (Cmax) \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1\u20133 gi\u1edd k\u1ec3 t\u1eeb khi u\u1ed1ng.<\/span><\/p>\n
Ph\u00e2n b\u1ed1<\/span><\/h4>\n
Thu\u1ed1c g\u1eafn ch\u1eb7t v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng, t\u1ef7 l\u1ec7 li\u00ean k\u1ebft kho\u1ea3ng 98\u201399%, ch\u1ee7 y\u1ebfu v\u1edbi albumin.<\/span><\/p>\n
Chuy\u1ec3n h\u00f3a<\/span><\/h4>\n
Acenocoumarol sau khi \u0111\u01b0\u1ee3c h\u1ea5p thu s\u1ebd \u0111\u01b0\u1ee3c gan x\u1eed l\u00fd ch\u1ee7 y\u1ebfu th\u00f4ng qua h\u1ec7 enzym cytochrome P450, trong \u0111\u00f3 quan tr\u1ecdng nh\u1ea5t l\u00e0 CYP2C9. Ngo\u00e0i ra, c\u00e1c isoenzym nh\u01b0 CYP1A2 v\u00e0 CYP2C19 c\u0169ng tham gia v\u00e0o qu\u00e1 tr\u00ecnh n\u00e0y nh\u01b0ng \u1edf m\u1ee9c \u0111\u1ed9 \u00edt h\u01a1n.\u00a0<\/span><\/p>\n
Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a di\u1ec5n ra ch\u1ee7 y\u1ebfu b\u1eb1ng ph\u1ea3n \u1ee9ng hydroxyl h\u00f3a t\u1ea1i c\u00e1c v\u1ecb tr\u00ed 6 v\u00e0 7 c\u1ee7a ph\u00e2n t\u1eed, \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh c\u00e1c d\u1eabn ch\u1ea5t amin ho\u1eb7c acetamide. C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y nh\u00ecn chung kh\u00f4ng c\u00f2n ho\u1ea1t t\u00ednh kh\u00e1ng \u0111\u00f4ng \u0111\u00e1ng k\u1ec3.\u00a0<\/span><\/p>\n
\u0110\u00e1ng ch\u00fa \u00fd, s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 ki\u1ec3u gen CYP2C9 \u1edf t\u1eebng c\u00e1 th\u1ec3 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 chuy\u1ec3n h\u00f3a, t\u1eeb \u0111\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn li\u1ec1u d\u00f9ng v\u00e0 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a m\u1ed7i b\u1ec7nh nh\u00e2n.<\/span><\/p>\n
Th\u1ea3i tr\u1eeb<\/span><\/h4>\n
Th\u1eddi gian b\u00e1n th\u1ea3i (half-life) c\u1ee7a acenocoumarol n\u1eb1m trong kho\u1ea3ng 8\u201311 gi\u1edd. Sau khi u\u1ed1ng, kho\u1ea3ng \u224829% \u0111\u01b0\u1ee3c th\u1ea3i ra qua ph\u00e2n v\u00e0 \u224860% qua n\u01b0\u1edbc ti\u1ec3u (d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a).<\/span><\/p>\n
Thu\u1ed1c Acenocoumarol \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n
Acenocoumarol 1 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/span><\/p>\n
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Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 d\u1ef1 ph\u00f2ng t\u1eafc m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n c\u00f3 van tim nh\u00e2n t\u1ea1o, h\u1eb9p van hai l\u00e1 ho\u1eb7c rung nh\u0129, gi\u00fap h\u1ea1n ch\u1ebf nguy c\u01a1 nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i kh\u00e1c.\u00a0<\/span><\/li>\n
Thu\u1ed1c c\u00f2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thay th\u1ebf heparin trong giai \u0111o\u1ea1n c\u1ea7n ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t huy\u1ebft kh\u1ed1i, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi c\u00f3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi heparin.<\/span><\/li>\n
Acenocoumarol \u0111\u01b0\u1ee3c d\u00f9ng ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t nh\u1ed3i m\u00e1u c\u01a1 tim \u1edf b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p aspirin, c\u0169ng nh\u01b0 gi\u1ea3m nguy c\u01a1 huy\u1ebft kh\u1ed1i sau nh\u1ed3i m\u00e1u c\u01a1 tim c\u00f3 bi\u1ebfn ch\u1ee9ng.\u00a0<\/span><\/li>\n
Thu\u1ed1c c\u0169ng c\u00f3 vai tr\u00f2 trong d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u v\u00e0 thuy\u00ean t\u1eafc ph\u1ed5i, nh\u1ea5t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n ph\u1ea3i ph\u1eabu thu\u1eadt thay kh\u1edbp h\u00e1ng ho\u1eb7c c\u00e1c ph\u1eabu thu\u1eadt c\u00f3 nguy c\u01a1 cao.<\/span><\/li>\n
Ngo\u00e0i ra, thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ph\u00f2ng ng\u1eeba huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn \u1ed1ng th\u00f4ng m\u1ea1ch m\u00e1u v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u00e3 h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u hay ngh\u1ebdn m\u1ea1ch ph\u1ed5i<\/span><\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c Acenocoumarol<\/span><\/h2>\n
Acenocoumarol 1 li\u1ec1u d\u00f9ng<\/span><\/h3>\n
Nguy\u00ean t\u1eafc chung: li\u1ec1u l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng v\u00e0 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m INR c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n.<\/span><\/p>\n
Li\u1ec1u kh\u1edfi \u0111\u1ea7u:<\/span><\/p>\n
Ng\u00e0y \u0111\u1ea7u: kho\u1ea3ng 2 -4 mg (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 2 -4 vi\u00ean 1 mg), kh\u00f4ng d\u00f9ng li\u1ec1u ban \u0111\u1ea7u cao h\u01a1n<\/span><\/p>\n
Ng\u00e0y th\u1ee9 hai: c\u00f3 th\u1ec3 t\u0103ng l\u00ean 4 mg\/ng\u00e0y t\u00f9y t\u00ecnh tr\u1ea1ng \u0111\u00f4ng m\u00e1u.<\/span><\/p>\n
Li\u1ec1u duy tr\u00ec: th\u01b0\u1eddng dao \u0111\u1ed9ng t\u1eeb 1\u20138 mg\/ng\u00e0y. Khi c\u1ea7n thay \u0111\u1ed5i li\u1ec1u, vi\u1ec7c hi\u1ec7u ch\u1ec9nh n\u00ean ti\u1ebfn h\u00e0nh t\u1eebng b\u01b0\u1edbc nh\u1ecf (1 mg m\u1ed7i l\u1ea7n) \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n.<\/span><\/p>\n
Ng\u01b0\u1eddi cao tu\u1ed5i: do nguy c\u01a1 nh\u1ea1y c\u1ea3m cao h\u01a1n, th\u01b0\u1eddng c\u1ea7n d\u00f9ng li\u1ec1u th\u1ea5p h\u01a1n, ch\u1ec9 b\u1eb1ng \u00bd \u0111\u1ebfn \u00be li\u1ec1u th\u00f4ng th\u01b0\u1eddng.<\/span><\/p>\n
Chuy\u1ec3n t\u1eeb heparin sang Acenocoumarol 1: ti\u1ebfp t\u1ee5c duy tr\u00ec heparin cho \u0111\u1ebfn khi gi\u00e1 tr\u1ecb INR \u1ed5n \u0111\u1ecbnh trong ng\u01b0\u1ee1ng \u0111i\u1ec1u tr\u1ecb li\u00ean ti\u1ebfp 2 ng\u00e0y, sau \u0111\u00f3 m\u1edbi d\u1eebng heparin.<\/span><\/p>\n
Tr\u01b0\u1edbc ph\u1eabu thu\u1eadt: c\u1ea7n ng\u01b0ng thu\u1ed1c \u00edt nh\u1ea5t 5 ng\u00e0y, trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n \u0111\u1ea3o ng\u01b0\u1ee3c nhanh t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng, c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng vitamin K theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/span><\/p>\n
C\u00e1ch s\u1eed d\u1ee5ng thu\u1ed1c Acenocoumarol<\/span><\/h3>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, vi\u00ean thu\u1ed1c c\u1ea7n \u0111\u01b0\u1ee3c nu\u1ed1t nguy\u00ean v\u1edbi n\u01b0\u1edbc, kh\u00f4ng n\u00ean b\u1ebb, nghi\u1ec1n ho\u1eb7c nhai v\u00e0 n\u00ean u\u1ed1ng v\u00e0o m\u1ed9t th\u1eddi \u0111i\u1ec3m c\u1ed1 \u0111\u1ecbnh m\u1ed7i ng\u00e0y \u0111\u1ec3 duy tr\u00ec hi\u1ec7u qu\u1ea3 \u1ed5n \u0111\u1ecbnh.<\/span><\/p>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Acenocoumarol trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n
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Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 d\u1ecb \u1ee9ng v\u1edbi acenocoumarol, c\u00e1c d\u1eabn xu\u1ea5t coumarin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/span><\/li>\n
Ph\u1ee5 n\u1eef mang thai v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho thai nhi.<\/span><\/li>\n
B\u1ec7nh nh\u00e2n \u0111ang trong t\u00ecnh tr\u1ea1ng nguy c\u01a1 xu\u1ea5t huy\u1ebft cao, v\u00ed d\u1ee5: t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng, lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng, m\u1edbi ph\u1eabu thu\u1eadt l\u1edbn, ho\u1eb7c c\u00f3 t\u1ed5n th\u01b0\u01a1ng d\u1ec5 ch\u1ea3y m\u00e1u.<\/span><\/li>\n
Ng\u01b0\u1eddi m\u1eafc b\u1ec7nh gan n\u1eb7ng ho\u1eb7c suy gan ti\u1ebfn tri\u1ec3n, v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u.<\/span><\/li>\n
B\u1ec7nh nh\u00e2n v\u1eeba tr\u1ea3i qua ph\u1eabu thu\u1eadt th\u1ea7n kinh, nh\u00e3n khoa ho\u1eb7c t\u1ee7y s\u1ed1ng, n\u01a1i vi\u1ec7c ch\u1ea3y m\u00e1u d\u00f9 nh\u1ecf c\u0169ng c\u00f3 th\u1ec3 g\u00e2y bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng.<\/span><\/li>\n
Ng\u01b0\u1eddi b\u1ecb xu\u1ea5t huy\u1ebft n\u1ed9i t\u1ea1ng ti\u1ebfn tri\u1ec3n (nh\u01b0 ch\u1ea3y m\u00e1u ti\u00eau h\u00f3a, ti\u1ebft ni\u1ec7u \u2013 sinh d\u1ee5c, n\u00e3o\u2026).<\/span><\/li>\n
Tr\u01b0\u1eddng h\u1ee3p huy\u1ebft \u00e1p kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed ph\u00ecnh m\u1ea1ch n\u00e3o.<\/span><\/li>\n
Kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n suy tim n\u1eb7ng k\u00e8m nguy c\u01a1 \u1ee9 huy\u1ebft, do d\u1ec5 l\u00e0m n\u1eb7ng th\u00eam t\u00ecnh tr\u1ea1ng xu\u1ea5t huy\u1ebft<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Acenocoumarol<\/span><\/h2>\n
Th\u1eadn tr\u1ecdng<\/span><\/h3>\n
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Theo d\u00f5i INR th\u01b0\u1eddng xuy\u00ean: trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c ki\u1ec3m tra ch\u1ec9 s\u1ed1 \u0111\u00f4ng m\u00e1u \u0111\u1ec1u \u0111\u1eb7n \u0111\u1ec3 k\u1ecbp th\u1eddi \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/span><\/li>\n
Ng\u01b0\u1eddi cao tu\u1ed5i th\u01b0\u1eddng nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c, d\u1ec5 g\u1eb7p bi\u1ebfn c\u1ed1 ch\u1ea3y m\u00e1u n\u00ean c\u1ea7n b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u th\u1ea5p v\u00e0 theo d\u00f5i s\u00e1t.<\/span><\/li>\n
B\u1ec7nh nh\u00e2n suy gan ho\u1eb7c suy th\u1eadn nh\u1eb9 \u0111\u1ebfn v\u1eeba: do kh\u1ea3 n\u0103ng chuy\u1ec3n h\u00f3a v\u00e0 th\u1ea3i tr\u1eeb thu\u1ed1c gi\u1ea3m, c\u00f3 nguy c\u01a1 t\u00edch l\u0169y v\u00e0 t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5.<\/span><\/li>\n
Khi c\u00f3 ti\u1ec1n s\u1eed lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng, b\u1ec7nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, vi\u00eam m\u1ea1ch, t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng ho\u1eb7c sau ph\u1eabu thu\u1eadt l\u1edbn, ph\u1ea3i d\u00f9ng r\u1ea5t th\u1eadn tr\u1ecdng v\u00ec nguy c\u01a1 ch\u1ea3y m\u00e1u cao.<\/span><\/li>\n
\u1ede ng\u01b0\u1eddi thi\u1ebfu h\u1ee5t b\u1ea9m sinh protein C ho\u1eb7c protein S, nguy c\u01a1 xu\u1ea5t hi\u1ec7n huy\u1ebft kh\u1ed1i ngh\u1ecbch l\u00fd t\u0103ng l\u00ean trong giai \u0111o\u1ea1n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, c\u1ea7n theo d\u00f5i v\u00e0 ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c n\u1ebfu c\u1ea7n.<\/span><\/li>\n
Tr\u00e1nh d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n di truy\u1ec1n hi\u1ebfm g\u1eb7p nh\u01b0 kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu h\u1ee5t lactase ho\u1eb7c h\u1ed9i ch\u1ee9ng k\u00e9m h\u1ea5p thu glucose.<\/span><\/li>\n
Ng\u01b0\u1eddi b\u1ec7nh n\u00ean duy tr\u00ec ch\u1ebf \u0111\u1ed9 \u0103n \u1ed5n \u0111\u1ecbnh v\u1edbi vitamin K, h\u1ea1n ch\u1ebf thay \u0111\u1ed5i \u0111\u1ed9t ng\u1ed9t l\u01b0\u1ee3ng rau xanh \u0111\u1eadm m\u00e0u, v\u00ec c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1eb7c t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n
Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 g\u1eb7p m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng ph\u1ee5 \u1edf nhi\u1ec1u m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau:<\/span><\/p>\n
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Ch\u1ea3y m\u00e1u: l\u00e0 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i th\u01b0\u1eddng g\u1eb7p nh\u1ea5t, c\u00f3 th\u1ec3 bi\u1ec3u hi\u1ec7n \u1edf nhi\u1ec1u v\u1ecb tr\u00ed nh\u01b0 ch\u1ea3y m\u00e1u cam, ch\u1ea3y m\u00e1u n\u01b0\u1edbu, ti\u1ec3u ra m\u00e1u, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a ho\u1eb7c th\u1eadm ch\u00ed ch\u1ea3y m\u00e1u n\u1ed9i s\u1ecd trong tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng.<\/span><\/li>\n
T\u00e1c d\u1ee5ng tr\u00ean da v\u00e0 m\u00f4 m\u1ec1m: m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p xu\u1ea5t hi\u1ec7n ban \u0111\u1ecf, ph\u00e1t ban d\u1ecb \u1ee9ng, b\u1ea7m t\u00edm b\u1ea5t th\u01b0\u1eddng ho\u1eb7c ho\u1ea1i t\u1eed da (th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn thi\u1ebfu h\u1ee5t protein C\/S).<\/span><\/li>\n
\u0110\u01b0\u1eddng ti\u00eau h\u00f3a: c\u00f3 th\u1ec3 g\u1eb7p bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y, ch\u00e1n \u0103n ho\u1eb7c vi\u00eam d\u1ea1 d\u00e0y.<\/span><\/li>\n
Gan m\u1eadt: hi\u1ebfm khi ghi nh\u1eadn t\u00ecnh tr\u1ea1ng t\u0103ng men gan, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan.<\/span><\/li>\n
Th\u1ea7n kinh: xu\u1ea5t hi\u1ec7n \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 ho\u1eb7c c\u1ea3m gi\u00e1c m\u1ec7t m\u1ecfi.<\/span><\/li>\n
C\u00e1c t\u00e1c d\u1ee5ng kh\u00e1c: \u0111au kh\u1edbp, s\u1ed1t nh\u1eb9, r\u1ee5ng t\u00f3c, n\u1ed5i m\u1ea9n ng\u1ee9a.<\/span><\/li>\n<\/ul>\n
T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n
Kh\u00f4ng k\u1ebft h\u1ee3p Acenocoumarol 1 v\u1edbi m\u1ed9t s\u1ed1 thu\u1ed1c nh\u01b0 aspirin, miconazol, phenylbutazon ho\u1eb7c c\u00e1c NSAID nh\u00f3m pyrazol, v\u00ec s\u1ef1 ph\u1ed1i h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng m\u1ea1nh t\u00e1c d\u1ee5ng kh\u00e1ng \u0111\u00f4ng v\u00e0 d\u1eabn t\u1edbi nguy c\u01a1 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng.<\/span><\/p>\n
Ngo\u00e0i ra, c\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c ho\u1ea1t ch\u1ea5t sau, v\u00ec ch\u00fang c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i hi\u1ec7u l\u1ef1c ch\u1ed1ng \u0111\u00f4ng c\u1ee7a Acenocoumarol:<\/span><\/p>\n
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Thu\u1ed1c n\u1ed9i ti\u1ebft ho\u1eb7c \u0111i\u1ec1u bi\u1ebfn hormon: aminoglutethimid, androgen.<\/span><\/li>\n
Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb tim m\u1ea1ch v\u00e0 h\u00f4 h\u1ea5p: bosentan, nh\u00f3m heparin.<\/span><\/li>\n
Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh: carbamazepin.<\/span><\/li>\n
Kh\u00e1ng sinh: nh\u00f3m cephalosporin.<\/span><\/li>\n
Nh\u00f3m azol ch\u1ed1ng n\u1ea5m (imidazol): nh\u01b0 ketoconazol, econazol.<\/span><\/li>\n<\/ul>\n
Ngo\u00e0i ra, nhi\u1ec1u lo\u1ea1i thu\u1ed1c kh\u00e1c (kh\u00e1ng sinh, thu\u1ed1c h\u1ea1 lipid m\u00e1u, corticosteroid, thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m…) c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng ho\u1eb7c gi\u1ea3m t\u00e1c d\u1ee5ng kh\u00e1ng \u0111\u00f4ng, v\u00ec v\u1eady trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng Acenocoumarol, b\u1ec7nh nh\u00e2n c\u1ea7n th\u00f4ng b\u00e1o \u0111\u1ea7y \u0111\u1ee7 cho b\u00e1c s\u0129 t\u1ea5t c\u1ea3 thu\u1ed1c v\u00e0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng \u0111ang d\u00f9ng.<\/span><\/p>\n
Th\u1ef1c ph\u1ea9m v\u00e0 th\u1ea3o d\u01b0\u1ee3c: c\u00e1c s\u1ea3n ph\u1ea9m gi\u00e0u vitamin K (rau xanh \u0111\u1eadm m\u00e0u, gan \u0111\u1ed9ng v\u1eadt…) c\u00f3 th\u1ec3 gi\u1ea3m hi\u1ec7u l\u1ef1c ch\u1ed1ng \u0111\u00f4ng, trong khi m\u1ed9t s\u1ed1 th\u1ea3o d\u01b0\u1ee3c nh\u01b0 ginkgo, t\u1ecfi ho\u1eb7c g\u1eebng l\u1ea1i l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft.<\/span><\/p>\n
L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/span><\/h3>\n
Ph\u1ee5 n\u1eef c\u00f3 thai: T\u00e0i li\u1ec7u th\u1ed1ng k\u00ea cho bi\u1ebft c\u00f3 kho\u1ea3ng 4% tr\u01b0\u1eddng h\u1ee3p d\u1ecb t\u1eadt thai nhi khi ng\u01b0\u1eddi m\u1eb9 s\u1eed d\u1ee5ng thu\u1ed1c trong 3 th\u00e1ng \u0111\u1ea7u thai k\u1ef3. Ngo\u00e0i ra, d\u00f9ng trong c\u00e1c giai \u0111o\u1ea1n sau c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ea3y thai ho\u1eb7c ch\u1ea3y m\u00e1u trong thai. V\u00ec v\u1eady, Acenocoumarol 1 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho ph\u1ee5 n\u1eef mang thai, tr\u1eeb khi kh\u00f4ng c\u00f3 gi\u1ea3i ph\u00e1p thay th\u1ebf b\u1eb1ng heparin.<\/span><\/p>\n
Ph\u1ee5 n\u1eef cho con b\u00fa: M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf thu\u1ed1c c\u00f3 th\u1ec3 \u0111i qua s\u1eefa m\u1eb9. Do \u0111\u00f3, c\u1ea7n c\u00e2n nh\u1eafc nguy c\u01a1 \u2013 l\u1ee3i \u00edch tr\u01b0\u1edbc khi d\u00f9ng cho ph\u1ee5 n\u1eef \u0111ang nu\u00f4i con b\u00fa, v\u00e0 tr\u1ebb s\u01a1 sinh c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd v\u1ec1 d\u1ea5u hi\u1ec7u r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u.<\/span><\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/span><\/h3>\n
Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u ho\u1eb7c m\u1ec7t m\u1ecfi \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. Nh\u1eefng bi\u1ec3u hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 kh\u1ea3 n\u0103ng ph\u1ea3n \u1ee9ng nhanh, do \u0111\u00f3 ng\u01b0\u1eddi \u0111ang d\u00f9ng Acenocoumarol 1 c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe, \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/span><\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n
Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u: th\u01b0\u1eddng bi\u1ec3u hi\u1ec7n b\u1eb1ng c\u00e1c d\u1ea5u hi\u1ec7u xu\u1ea5t huy\u1ebft nh\u01b0 ch\u1ea3y m\u00e1u cam, ch\u1ea3y m\u00e1u l\u1ee3i, b\u1ea7m t\u00edm b\u1ea5t th\u01b0\u1eddng, ti\u1ec3u ra m\u00e1u, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a ho\u1eb7c n\u1ed9i s\u1ecd.<\/span><\/p>\n
H\u01b0\u1edbng x\u1eed tr\u00ed:<\/span><\/p>\n
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V\u1edbi tr\u01b0\u1eddng h\u1ee3p nh\u1eb9: c\u00f3 th\u1ec3 ng\u1eebng thu\u1ed1c v\u00e0 theo d\u00f5i INR.<\/span><\/li>\n
Khi INR t\u0103ng qu\u00e1 cao ho\u1eb7c c\u00f3 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng: c\u00e2n nh\u1eafc truy\u1ec1n vitamin K \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch, k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ch\u1ebf ph\u1ea9m ch\u1ee9a y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u (huy\u1ebft t\u01b0\u01a1ng t\u01b0\u01a1i \u0111\u00f4ng l\u1ea1nh, ph\u1ee9c h\u1ee3p prothrombin) n\u1ebfu c\u1ea7n.<\/span><\/li>\n
Trong m\u1ecdi t\u00ecnh hu\u1ed1ng, vi\u1ec7c x\u1eed tr\u00ed ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a b\u00e1c s\u0129 v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng \u0111\u00f4ng m\u00e1u<\/span><\/li>\n<\/ul>\n
B\u1ea3o qu\u1ea3n<\/span><\/h3>\n
Gi\u1eef thu\u1ed1c \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C, n\u01a1i kh\u00f4 r\u00e1o v\u00e0 tho\u00e1ng m\u00e1t, tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp v\u00e0 kh\u00f4ng \u0111\u1ec3 \u1edf n\u01a1i \u1ea9m \u01b0\u1edbt.<\/span><\/p>\n
B\u1ea3o qu\u1ea3n thu\u1ed1c trong bao b\u00ec g\u1ed1c, \u0111\u1ea3m b\u1ea3o k\u00edn n\u1eafp sau khi s\u1eed d\u1ee5ng.<\/span><\/p>\n
Thu\u1ed1c Acenocoumarol gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n
Thu\u1ed1c Acenocoumarol 1mg hi\u1ec7n nay gi\u00e1 bao nhi\u00eau? Gi\u00e1 thu\u1ed1c Acenocoumarol c\u00f3 th\u1ec3 dao \u0111\u1ed9ng t\u00f9y t\u1eebng nh\u00e0 thu\u1ed1c v\u00e0 khu v\u1ef1c. Kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 mang \u0111\u01a1n thu\u1ed1c \u0111\u1ebfn c\u00e1c \u0111\u1ecba ch\u1ec9 kinh doanh d\u01b0\u1ee3c ph\u1ea9m tr\u00ean to\u00e0n qu\u1ed1c \u0111\u1ec3 mua \u0111\u01b0\u1ee3c. Qu\u00fd kh\u00e1ch h\u00e0ng n\u00ean t\u00ecm hi\u1ec3u v\u00e0 l\u1ef1a ch\u1ecdn c\u00e1c \u0111\u1ecba \u0111i\u1ec3m uy t\u00edn \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o mua \u0111\u01b0\u1ee3c thu\u1ed1c an to\u00e0n, ch\u1ea5t l\u01b0\u1ee3ng, c\u00f3 ngu\u1ed3n g\u1ed1c r\u00f5 r\u00e0ng.<\/span><\/p>\n
Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o th\u00eam c\u00e1c thu\u1ed1c kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng nh\u01b0:<\/span><\/p>\n
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Azenmarol 1<\/span><\/a> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i t\u1eafc m\u1ea1ch do van tim nh\u00e2n t\u1ea1o, b\u1ec7nh van hai l\u00e1, rung nh\u0129 ho\u1eb7c sau nh\u1ed3i m\u00e1u c\u01a1 tim.\u00a0<\/span><\/li>\n
Acenocoumarol-VNP 4<\/a> c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng m\u00e1u, t\u1ea1o huy\u1ebft kh\u1ed1i g\u00e2y t\u1eafc m\u1ea1ch.\u00a0<\/span><\/li>\n<\/ul>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n
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H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c <\/span>Acenocoumarol 1<\/span> do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i file t\u1ea1i \u0111\u00e2y.<\/a><\/span><\/li>\n
Acenocoumarol. Truy c\u1eadp ng\u00e0y 10 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <\/span>https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Acenocoumarol<\/span><\/a>\u00a0<\/span><\/li>\n
Parveen Kumar, Puneet Kapoor. Acenocoumarol\u2019s pharmacokinetic: linear or not. Truy c\u1eadp ng\u00e0y 03 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <\/span>https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6785764\/<\/span><\/a>\u00a0<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Acenocoumarol 1 l\u00e0 thu\u1ed1c kh\u00e1ng \u0111\u00f4ng d\u1ea1ng u\u1ed1ng, \u1ee9c ch\u1ebf vitamin K, gi\u00fap ph\u00f2ng ng\u1eeba v\u00e0 ki\u1ec3m so\u00e1t huy\u1ebft kh\u1ed1i, th\u01b0\u1eddng d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tim m\u1ea1ch v\u00e0 sau ph\u1eabu thu\u1eadt.<\/span><\/p>\n","protected":false},"author":1,"featured_media":138013,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-137999","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/137999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=137999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/138013"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=137999"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=137999"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=137999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}