{"id":136443,"date":"2025-09-03T11:21:59","date_gmt":"2025-09-03T04:21:59","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=136443"},"modified":"2026-01-04T13:07:04","modified_gmt":"2026-01-04T06:07:04","slug":"janumet-50mg-850mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/janumet-50mg-850mg\/","title":{"rendered":"Janumet 50mg\/850mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong><a href=\"https:\/\/vnras.com\/drug\/janumet-50mg-850mg\/\">Janumet 50mg\/850mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Patheon Puerto Rico, Inc., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 001110999524 (VN-17103-13).<\/strong><\/p>\n<h2>Janumet 50mg\/850mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Janumet 50mg\/850mg<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c k\u00ea \u0111\u01a1n, \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n ph\u1ed1i h\u1ee3p hai ho\u1ea1t ch\u1ea5t tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng:<\/p>\n<ul>\n<li><strong>Sitagliptin<\/strong> (d\u01b0\u1edbi d\u1ea1ng Sitagliptin phosphat monohydrat): 50mg<\/li>\n<li>Metformin hydrochloride: 850mg<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 001110999524 (VN-17103-13)<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 4 v\u1ec9 x 7 vi\u00ean, H\u1ed9p 8 v\u1ec9 x 7 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Puerto Rico<\/p>\n<figure id=\"attachment_136449\" aria-describedby=\"caption-attachment-136449\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-136449\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Janumet-50mg850mg.jpg\" alt=\"Janumet 50mg\/850mg \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00edp 2\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Janumet-50mg850mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Janumet-50mg850mg-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Janumet-50mg850mg-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/09\/Janumet-50mg850mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-136449\" class=\"wp-caption-text\">Janumet 50mg\/850mg \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00edp 2<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Janumet 50mg\/850mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Janumet k\u1ebft h\u1ee3p s\u1ee9c m\u1ea1nh c\u1ee7a hai nh\u00f3m thu\u1ed1c tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u1edbi c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng ri\u00eang bi\u1ec7t nh\u01b0ng hi\u1ec7p \u0111\u1ed3ng, mang l\u1ea1i hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft to\u00e0n di\u1ec7n.<\/p>\n<ul>\n<li>Metformin hydrochloride: Thu\u1ed9c nh\u00f3m Biguanide, Metformin l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c n\u1ec1n t\u1ea3ng trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2. C\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a Metformin kh\u00f4ng k\u00edch th\u00edch t\u1ee5y ti\u1ebft insulin m\u00e0 t\u1eadp trung v\u00e0o ba m\u1ee5c ti\u00eau:\n<ul>\n<li>Gi\u1ea3m s\u1ea3n xu\u1ea5t glucose t\u1ea1i gan (gi\u1ea3m t\u00e2n t\u1ea1o glucose).<\/li>\n<li>Gi\u1ea3m h\u1ea5p thu glucose t\u1eeb ru\u1ed9t.<\/li>\n<li>T\u0103ng \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a insulin \u1edf c\u00e1c m\u00f4 ngo\u1ea1i vi (c\u01a1, m\u1ee1), gi\u00fap c\u01a1 th\u1ec3 s\u1eed d\u1ee5ng glucose hi\u1ec7u qu\u1ea3 h\u01a1n.<\/li>\n<\/ul>\n<\/li>\n<li>Sitagliptin: L\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh v\u00e0 ch\u1ecdn l\u1ecdc enzyme dipeptidyl peptidase-4 (DPP-4). C\u01a1 ch\u1ebf c\u1ee7a Sitagliptin d\u1ef1a tr\u00ean h\u1ec7 th\u1ed1ng incretin n\u1ed9i sinh. Incretin (bao g\u1ed3m GLP-1 v\u00e0 GIP) l\u00e0 c\u00e1c hormone \u0111\u01b0\u1ee3c ru\u1ed9t ti\u1ebft ra sau b\u1eefa \u0103n, c\u00f3 vai tr\u00f2 k\u00edch th\u00edch tuy\u1ebfn t\u1ee5y t\u0103ng ti\u1ebft insulin v\u00e0 \u1ee9c ch\u1ebf ti\u1ebft glucagon (m\u1ed9t hormone l\u00e0m t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft) m\u1ed9t c\u00e1ch ph\u1ee5 thu\u1ed9c v\u00e0o n\u1ed3ng \u0111\u1ed9 glucose trong m\u00e1u. Enzyme DPP-4 s\u1ebd nhanh ch\u00f3ng ph\u00e2n h\u1ee7y c\u00e1c incretin n\u00e0y. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf DPP-4, Sitagliptin l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 k\u00e9o d\u00e0i th\u1eddi gian ho\u1ea1t \u0111\u1ed9ng c\u1ee7a incretin, t\u1eeb \u0111\u00f3 t\u0103ng c\u01b0\u1eddng gi\u1ea3i ph\u00f3ng insulin t\u1eeb t\u1ebf b\u00e0o beta c\u1ee7a t\u1ee5y khi \u0111\u01b0\u1eddng huy\u1ebft t\u0103ng.<\/li>\n<\/ul>\n<p>S\u1ef1 k\u1ebft h\u1ee3p n\u00e0y mang t\u00ednh b\u1ed5 sung ho\u00e0n h\u1ea3o: Metformin gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng \u0111\u1ec1 kh\u00e1ng insulin v\u00e0 gi\u1ea3m s\u1ea3n xu\u1ea5t glucose n\u1ec1n, trong khi Sitagliptin t\u0103ng c\u01b0\u1eddng \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1ee5y v\u1edbi b\u1eefa \u0103n, gi\u00fap ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft sau \u0103n hi\u1ec7u qu\u1ea3.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: \u0110\u1ed1i v\u1edbi Metformin, sinh kh\u1ea3 d\u1ee5ng khi b\u1ee5ng \u0111\u00f3i kho\u1ea3ng 50-60%. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m nh\u1eb9 v\u00e0 l\u00e0m ch\u1eadm t\u1ed1c \u0111\u1ed9 h\u1ea5p thu Metformin, nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn Sitagliptin.<\/p>\n<p>Ph\u00e2n b\u1ed1: Sitagliptin c\u00f3 t\u1ef7 l\u1ec7 li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng th\u1ea5p (38%). Metformin g\u1eafn k\u1ebft kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 ph\u00e2n b\u1ed1 v\u00e0o h\u1ed3ng c\u1ea7u.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Sitagliptin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ed9t ph\u1ea7n nh\u1ecf, ch\u1ee7 y\u1ebfu qua CYP3A4 v\u00e0 CYP2C8. Metformin kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a \u1edf gan.<\/p>\n<p>Th\u1ea3i tr\u1eeb: C\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Sitagliptin kho\u1ea3ng 12.4 gi\u1edd, trong khi c\u1ee7a Metformin l\u00e0 kho\u1ea3ng 6.2 gi\u1edd trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<h2>Thu\u1ed1c Janumet 50mg\/850mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Janumet \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p h\u1ed7 tr\u1ee3 ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 v\u1eadn \u0111\u1ed9ng th\u1ec3 l\u1ef1c \u0111\u1ec3 c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2 trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/p>\n<ul>\n<li>Li\u1ec7u ph\u00e1p kh\u1edfi \u0111\u1ea7u khi ch\u1ebf \u0111\u1ed9 \u0103n v\u00e0 v\u1eadn \u0111\u1ed9ng kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/li>\n<li>B\u1ec7nh nh\u00e2n ch\u01b0a ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c \u0111\u01b0\u1eddng huy\u1ebft v\u1edbi \u0111\u01a1n tr\u1ecb li\u1ec7u Metformin \u1edf li\u1ec1u t\u1ed1i \u0111a.<\/li>\n<li>B\u1ec7nh nh\u00e2n \u0111\u00e3 d\u00f9ng li\u1ec7u ph\u00e1p ph\u1ed1i h\u1ee3p Sitagliptin v\u00e0 Metformin v\u1edbi c\u00e1c vi\u00ean ri\u00eang l\u1ebb.<\/li>\n<li>Li\u1ec7u ph\u00e1p ph\u1ed1i h\u1ee3p ba thu\u1ed1c v\u1edbi m\u1ed9t sulfonylurea (SU), m\u1ed9t ch\u1ea5t ch\u1ee7 v\u1eadn PPAR\u03b3 (nh\u01b0 pioglitazone), ho\u1eb7c v\u1edbi insulin khi c\u00e1c ph\u00e1c \u0111\u1ed3 hai thu\u1ed1c ch\u01b0a \u0111\u1ea1t hi\u1ec7u qu\u1ea3 mong mu\u1ed1n.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Janumet 50mg\/850mg<\/h2>\n<p>Li\u1ec1u d\u00f9ng c\u1ee7a Janumet c\u1ea7n \u0111\u01b0\u1ee3c c\u00e1 th\u1ec3 h\u00f3a d\u1ef1a tr\u00ean ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb hi\u1ec7n t\u1ea1i, hi\u1ec7u qu\u1ea3 v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n. Li\u1ec1u t\u1ed1i \u0111a khuy\u1ebfn c\u00e1o h\u00e0ng ng\u00e0y kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 100mg Sitagliptin.<\/p>\n<ul>\n<li>Li\u1ec1u th\u00f4ng th\u01b0\u1eddng l\u00e0 m\u1ed9t vi\u00ean, u\u1ed1ng hai l\u1ea7n m\u1ed7i ng\u00e0y.<\/li>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh d\u1ef1a tr\u00ean ph\u00e1c \u0111\u1ed3 b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng. B\u00e1c s\u0129 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u Metformin t\u1eeb t\u1eeb sau m\u1ed7i 1-2 tu\u1ea7n \u0111\u1ec3 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng dung n\u1ea1p \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Janumet 50mg\/850mg<\/h2>\n<p>\u0110\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u1ed1t nh\u1ea5t v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5, b\u1ec7nh nh\u00e2n n\u00ean u\u1ed1ng thu\u1ed1c c\u00f9ng v\u1edbi b\u1eefa \u0103n. U\u1ed1ng thu\u1ed1c trong ho\u1eb7c ngay sau b\u1eefa \u0103n gi\u00fap l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00f3 ch\u1ecbu tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a (nh\u01b0 bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y) th\u01b0\u1eddng g\u1eb7p do Metformin.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Janumet 50mg\/850mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng v\u1edbi \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn \u01b0\u1edbc t\u00ednh (eGFR) d\u01b0\u1edbi ng\u01b0\u1ee1ng 30 mL\/ph\u00fat\/1,73 m\u00b2.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u1edbi Sitagliptin, Metformin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m toan chuy\u1ec3n h\u00f3a \u1edf c\u1ea3 th\u1ec3 c\u1ea5p t\u00ednh v\u00e0 m\u1ea1n t\u00ednh, \u0111\u1eb7c bi\u1ec7t l\u00e0 bi\u1ebfn ch\u1ee9ng nhi\u1ec5m toan ceton do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>C\u00e1c t\u00ecnh tr\u1ea1ng c\u1ea5p t\u00ednh c\u00f3 nguy c\u01a1 l\u00e0m thay \u0111\u1ed5i ch\u1ee9c n\u0103ng th\u1eadn ho\u1eb7c g\u00e2y thi\u1ebfu oxy m\u00f4 nh\u01b0: m\u1ea5t n\u01b0\u1edbc, nhi\u1ec5m tr\u00f9ng n\u1eb7ng, s\u1ed1c, suy tim, suy h\u00f4 h\u1ea5p, nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p.<\/p>\n<p>Suy gan, ng\u1ed9 \u0111\u1ed9c r\u01b0\u1ee3u c\u1ea5p t\u00ednh, nghi\u1ec7n r\u01b0\u1ee3u.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Janumet 50mg\/850mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Li\u00ean quan \u0111\u1ebfn Metformin: Nguy c\u01a1 nhi\u1ec5m toan Lactic (Lactic Acidosis)<\/p>\n<ul>\n<li>\u0110\u00e2y l\u00e0 m\u1ed9t bi\u1ebfn ch\u1ee9ng chuy\u1ec3n h\u00f3a hi\u1ebfm g\u1eb7p nh\u01b0ng r\u1ea5t nghi\u00eam tr\u1ecdng, c\u00f3 t\u1ef7 l\u1ec7 t\u1eed vong cao n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi. Nguy c\u01a1 t\u0103ng l\u00ean \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, ng\u01b0\u1eddi cao tu\u1ed5i, ng\u01b0\u1eddi l\u1ea1m d\u1ee5ng r\u01b0\u1ee3u, ho\u1eb7c c\u00f3 c\u00e1c b\u1ec7nh l\u00fd g\u00e2y thi\u1ebfu oxy m\u00f4 (suy tim, suy h\u00f4 h\u1ea5p).<\/li>\n<li>C\u00e1c tri\u1ec7u ch\u1ee9ng kh\u1edfi ph\u00e1t c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1eb7c hi\u1ec7u, bao g\u1ed3m m\u1ec7t m\u1ecfi, \u0111au c\u01a1, kh\u00f3 th\u1edf, \u0111au b\u1ee5ng.<\/li>\n<li>B\u1ec7nh nh\u00e2n ph\u1ea3i ng\u01b0ng s\u1eed d\u1ee5ng Janumet v\u00e0 th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u0129 n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean.<\/li>\n<li>C\u1ea7n ng\u01b0ng thu\u1ed1c t\u1ea1m th\u1eddi tr\u01b0\u1edbc v\u00e0 trong v\u00f2ng 48 gi\u1edd sau khi th\u1ef1c hi\u1ec7n c\u00e1c th\u1ee7 thu\u1eadt ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh c\u00f3 s\u1eed d\u1ee5ng thu\u1ed1c c\u1ea3n quang ch\u1ee9a iod.<\/li>\n<\/ul>\n<p>Li\u00ean quan \u0111\u1ebfn Sitagliptin: Nguy c\u01a1 vi\u00eam t\u1ee5y c\u1ea5p (Acute Pancreatitis)<\/p>\n<ul>\n<li>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p vi\u00eam t\u1ee5y c\u1ea5p \u1edf b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng Sitagliptin.<\/li>\n<li>Tri\u1ec7u ch\u1ee9ng \u0111i\u1ec3n h\u00ecnh l\u00e0 \u0111au b\u1ee5ng d\u1eef d\u1ed9i, li\u00ean t\u1ee5c, c\u00f3 th\u1ec3 lan ra sau l\u01b0ng.<\/li>\n<li>B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o v\u1ec1 tri\u1ec7u ch\u1ee9ng n\u00e0y v\u00e0 c\u1ea7n ng\u1eebng thu\u1ed1c, li\u00ean h\u1ec7 y t\u1ebf ngay l\u1eadp t\u1ee9c n\u1ebfu nghi ng\u1edd b\u1ecb vi\u00eam t\u1ee5y c\u1ea5p.<\/li>\n<li>C\u00e1c nguy c\u01a1 kh\u00e1c bao g\u1ed3m \u0111au kh\u1edbp n\u1eb7ng v\u00e0 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn (ph\u1ea3n v\u1ec7, ph\u00f9 m\u1ea1ch, h\u1ed9i ch\u1ee9ng Stevens-Johnson).<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t ph\u1ed5 bi\u1ebfn\/Ph\u1ed5 bi\u1ebfn (ch\u1ee7 y\u1ebfu do Metformin): R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, ch\u00e1n \u0103n. C\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y th\u01b0\u1eddng x\u1ea3y ra khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 s\u1ebd gi\u1ea3m d\u1ea7n.<\/p>\n<p>Ph\u1ed5 bi\u1ebfn (ch\u1ee7 y\u1ebfu do Sitagliptin): Vi\u00eam m\u0169i h\u1ecdng, \u0111au \u0111\u1ea7u, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft (khi ph\u1ed1i h\u1ee3p v\u1edbi sulfonylurea ho\u1eb7c insulin).<\/p>\n<p>Nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi d\u00f9ng Janumet \u0111\u01a1n \u0111\u1ed9c l\u00e0 th\u1ea5p, v\u00ec c\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u c\u00f3 c\u01a1 ch\u1ebf ph\u1ee5 thu\u1ed9c v\u00e0o n\u1ecd\u0302ng \u0111\u1ecd\u0302 glucose.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>C\u00e1c thu\u1ed1c d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng th\u1eadn (v\u00ed d\u1ee5: thu\u1ed1c c\u1ea3n quang ch\u1ee9a iod, m\u1ed9t s\u1ed1 thu\u1ed1c NSAID) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic.<\/p>\n<p>R\u01b0\u1ee3u l\u00e0m t\u0103ng t\u00e1c \u0111\u1ed9ng c\u1ee7a Metformin l\u00ean chuy\u1ec3n h\u00f3a lactat, t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic.<\/p>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf OCT2 (nh\u01b0 ranolazine, cimetidine) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Metformin trong m\u00e1u.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7, kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Janumet trong thai k\u1ef3. Insulin th\u01b0\u1eddng l\u00e0 li\u1ec7u ph\u00e1p \u0111\u01b0\u1ee3c \u01b0u ti\u00ean.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Janumet do ch\u01b0a r\u00f5 thu\u1ed1c c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Janumet kh\u00f4ng c\u00f3 ho\u1eb7c c\u00f3 \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, tuy nhi\u00ean, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o v\u1ec1 nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, \u0111\u1eb7c bi\u1ec7t khi ph\u1ed1i h\u1ee3p Janumet v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c nh\u01b0 sulfonylurea ho\u1eb7c insulin.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Sitagliptin: \u00c1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 th\u00f4ng th\u01b0\u1eddng. Th\u1ea9m t\u00e1ch m\u00e1u c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf m\u1ed9t ph\u1ea7n Sitagliptin.<\/p>\n<p>Metformin: Qu\u00e1 li\u1ec1u Metformin c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec5m toan lactic, l\u00e0 m\u1ed9t t\u00ecnh tr\u1ea1ng c\u1ea5p c\u1ee9u y t\u1ebf. Th\u1ea9m ph\u00e2n m\u00e1u l\u00e0 ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7u qu\u1ea3 nh\u1ea5t \u0111\u1ec3 lo\u1ea1i b\u1ecf Metformin v\u00e0 \u0111i\u1ec1u ch\u1ec9nh t\u00ecnh tr\u1ea1ng nhi\u1ec5m toan.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c Janumet 50mg\/850mg \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C, \u1edf n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 \u0111\u1ed9 \u1ea9m.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Janumet 50mg\/850mg<\/h2>\n<p>M\u1ed9t s\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 ph\u1ed5 bi\u1ebfn l\u00e0 <a href=\"https:\/\/www.vnras.com\/drug\/janumet-50mg-1000mg\">Janumet 50mg\/1000mg<\/a>. S\u1ea3n ph\u1ea9m n\u00e0y ch\u1ee9a c\u00f9ng h\u00e0m l\u01b0\u1ee3ng Sitagliptin (50mg) nh\u01b0ng c\u00f3 h\u00e0m l\u01b0\u1ee3ng Metformin hydrochloride cao h\u01a1n (1000mg). Vi\u1ec7c l\u1ef1a ch\u1ecdn gi\u1eefa hai h\u00e0m l\u01b0\u1ee3ng n\u00e0y ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u Metformin m\u00e0 b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, c\u0169ng nh\u01b0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a h\u1ecd, theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Awadhesh Kumar Singh, Ashok Kumar Das. Efficacy of Dapagliflozin + Sitagliptin + Metformin Versus Sitagliptin + Metformin in T2DM Inadequately Controlled on Metformin Monotherapy: A Multicentric Randomized Trial, truy c\u1eadp ng\u00e0y 03 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39636567\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39636567\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Janumet 50mg\/850mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Patheon Puerto Rico, Inc., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 001110999524 (VN-17103-13), \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi l\u1edbn m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2.<\/p>\n","protected":false},"author":1,"featured_media":136448,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-136443","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/136443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=136443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/136448"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=136443"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=136443"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=136443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}