{"id":136007,"date":"2025-08-29T23:32:20","date_gmt":"2025-08-29T16:32:20","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=136007"},"modified":"2025-08-29T23:36:30","modified_gmt":"2025-08-29T16:36:30","slug":"savi-ivabradine-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/savi-ivabradine-5\/","title":{"rendered":"Savi Ivabradine 5"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Savi Ivabradine 5 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m SaVi c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-15174-11<\/strong><\/p>\n<h2>Savi Ivabradine 5 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Savi Ivabradine<\/strong> 5 c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Ivabradine (d\u01b0\u1edbi d\u1ea1ng hydrochloride) 5 mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-15174-11<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Savi Ivabradine 5<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Ivabradine t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean n\u00fat xoang tim, b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc d\u00f2ng ion If \u2013 m\u1ed9t d\u00f2ng \u0111i\u1ec7n quan tr\u1ecdng \u0111i\u1ec1u h\u00f2a qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c t\u1ef1 ph\u00e1t c\u1ee7a t\u1ebf b\u00e0o n\u00fat xoang. Nh\u1edd c\u01a1 ch\u1ebf n\u00e0y, thu\u1ed1c l\u00e0m gi\u1ea3m nh\u1ecbp tim m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u1eabn truy\u1ec1n trong tim, kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00e1i c\u1ef1c th\u1ea5t hay kh\u1ea3 n\u0103ng co b\u00f3p c\u01a1 tim. Ngo\u00e0i ra, ivabradine c\u00f3 th\u1ec3 g\u1eafn v\u1edbi d\u00f2ng ion \u1edf v\u00f5ng m\u1ea1c (d\u00f2ng Ih), li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng th\u00edch \u1ee9ng v\u1edbi \u00e1nh s\u00e1ng, t\u1ea1o n\u00ean t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1eb7c tr\u01b0ng l\u00e0 c\u1ea3m gi\u00e1c ch\u00f3i s\u00e1ng tho\u00e1ng qua.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Thu\u1ed1c h\u1ea5p thu nhanh g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 1 gi\u1edd khi d\u00f9ng l\u00fac \u0111\u00f3i. Sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 40% do chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u qua gan v\u00e0 ru\u1ed9t. D\u00f9ng thu\u1ed1c trong b\u1eefa \u0103n gi\u00fap \u1ed5n \u0111\u1ecbnh n\u1ed3ng \u0111\u1ed9 trong m\u00e1u.<\/p>\n<p>Ph\u00e2n b\u1ed1: Kho\u1ea3ng 70% li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 x\u1ea5p x\u1ec9 100 l\u00edt.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Chuy\u1ec3n h\u00f3a m\u1ea1nh qua enzym CYP3A4, t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 S 18982. Ivabradine kh\u00f4ng g\u00e2y c\u1ea3m \u1ee9ng hay \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 CYP3A4, nh\u01b0ng d\u1ec5 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c c\u1ea3m \u1ee9ng CYP3A4.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i ch\u00ednh kho\u1ea3ng 2 gi\u1edd, th\u1eddi gian b\u00e1n th\u1ea3i hi\u1ec7u l\u1ef1c kho\u1ea3ng 11 gi\u1edd. \u0110\u00e0o th\u1ea3i qua c\u1ea3 ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u, ch\u1ec9 kho\u1ea3ng 4% \u0111\u01b0\u1ee3c th\u1ea3i d\u01b0\u1edbi d\u1ea1ng nguy\u00ean v\u1eb9n.<\/p>\n<h2>Thu\u1ed1c Savi Ivabradine 5 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn c\u00f3 b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh, nh\u1ecbp xoang \u0111\u1ec1u, t\u1ea7n s\u1ed1 tim \u2265 70 nh\u1ecbp\/ph\u00fat.<\/p>\n<p>S\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p ho\u1eb7c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi thu\u1ed1c ch\u1eb9n beta.<\/p>\n<p>Ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c ch\u1eb9n beta khi li\u1ec1u t\u1ed1i \u01b0u kh\u00f4ng \u0111\u1ee7 ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb suy tim m\u1ea1n t\u00ednh m\u1ee9c \u0111\u1ed9 NYHA II \u2013 IV, c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u00e2m thu, nh\u1ecbp xoang, t\u1ea7n s\u1ed1 tim \u2265 75 nh\u1ecbp\/ph\u00fat, ph\u1ed1i h\u1ee3p c\u00f9ng \u0111i\u1ec1u tr\u1ecb chu\u1ea9n (bao g\u1ed3m ch\u1eb9n beta) ho\u1eb7c khi ch\u1eb9n beta b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\/kh\u00f4ng dung n\u1ea1p.<\/p>\n<figure id=\"attachment_136017\" aria-describedby=\"caption-attachment-136017\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-136017\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5.jpg\" alt=\"Savi Ivabradine 5\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Savi-Ivabradine-5-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-136017\" class=\"wp-caption-text\">Thu\u1ed1c Savi Ivabradine 5 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb \u0111au th\u1eaft ng\u1ef1c<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><em><strong>\u0110au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh<\/strong><\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 5 mg x 2 l\u1ea7n\/ng\u00e0y \u1edf b\u1ec7nh nh\u00e2n &lt; 75 tu\u1ed5i.<\/p>\n<p>Sau 3\u20134 tu\u1ea7n, n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f2n tri\u1ec7u ch\u1ee9ng v\u00e0 nh\u1ecbp tim l\u00fac ngh\u1ec9 &gt; 60 nh\u1ecbp\/ph\u00fat, c\u00f3 th\u1ec3 t\u0103ng l\u00ean 7,5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>N\u1ebfu nh\u1ecbp tim gi\u1ea3m &lt; 50 nh\u1ecbp\/ph\u00fat ho\u1eb7c xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng nh\u1ecbp ch\u1eadm (ch\u00f3ng m\u1eb7t, m\u1ec7t, t\u1ee5t huy\u1ebft \u00e1p), gi\u1ea3m li\u1ec1u xu\u1ed1ng 2,5 mg x 2 l\u1ea7n\/ng\u00e0y. Ng\u01b0ng thu\u1ed1c n\u1ebfu t\u00ecnh tr\u1ea1ng nh\u1ecbp ch\u1eadm v\u1eabn k\u00e9o d\u00e0i.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p sau 3 th\u00e1ng s\u1eed d\u1ee5ng m\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh kh\u00f4ng c\u00f3 ti\u1ebfn tri\u1ec3n r\u00f5 r\u1ec7t, c\u1ea7n d\u1eebng \u0111i\u1ec1u tr\u1ecb<\/p>\n<p><em><strong>Suy tim m\u1ea1n t\u00ednh<\/strong><\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Sau 2 tu\u1ea7n: \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo nh\u1ecbp tim.<\/p>\n<p>N\u1ebfu &gt; 60 nh\u1ecbp\/ph\u00fat: t\u0103ng l\u00ean 7,5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>N\u1ebfu &lt; 50 nh\u1ecbp\/ph\u00fat ho\u1eb7c c\u00f3 tri\u1ec7u ch\u1ee9ng nh\u1ecbp ch\u1eadm: gi\u1ea3m xu\u1ed1ng 2,5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>N\u1ebfu 50\u201360 nh\u1ecbp\/ph\u00fat: duy tr\u00ec li\u1ec1u 5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Ng\u01b0ng thu\u1ed1c n\u1ebfu nh\u1ecbp tim duy tr\u00ec &lt; 50 nh\u1ecbp\/ph\u00fat ho\u1eb7c tri\u1ec7u ch\u1ee9ng nh\u1ecbp ch\u1eadm kh\u00f4ng c\u1ea3i thi\u1ec7n d\u00f9 \u0111\u00e3 gi\u1ea3m li\u1ec1u.<\/p>\n<p><em><strong>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/strong><\/em><\/p>\n<p>Ng\u01b0\u1eddi \u2265 75 tu\u1ed5i: n\u00ean b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u 2,5 mg x 2 l\u1ea7n\/ng\u00e0y, t\u0103ng li\u1ec1u khi c\u1ea7n.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn (ClCr &gt; 15 ml\/ph\u00fat): kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. D\u1eef li\u1ec7u c\u00f2n h\u1ea1n ch\u1ebf khi ClCr &lt; 15 ml\/ph\u00fat.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan nh\u1eb9: d\u00f9ng Savi Ivabradine 5 kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. Suy gan trung b\u00ecnh: c\u1ea7n th\u1eadn tr\u1ecdng. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong suy gan n\u1eb7ng.<\/p>\n<p>Tr\u1ebb em &lt; 18 tu\u1ed5i:\u00a0\u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i hi\u1ec7n ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c minh<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>D\u00f9ng<strong> vi\u00ean n\u00e9n Savi Ivabradine 5<\/strong> \u0111\u01b0\u1eddng u\u1ed1ng, ng\u00e0y 2 l\u1ea7n v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 t\u1ed1i, n\u00ean u\u1ed1ng trong b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Savi Ivabradine 5 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi ivabradine ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Savi Ivabradine<\/p>\n<p>Nh\u1ecbp tim l\u00fac ngh\u1ec9 &lt; 70 nh\u1ecbp\/ph\u00fat tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>S\u1ed1c tim, nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p.<\/p>\n<p>Huy\u1ebft \u00e1p r\u1ea5t th\u1ea5p (&lt; 90\/50 mmHg).<\/p>\n<p>Suy gan n\u1eb7ng.<\/p>\n<p>R\u1ed1i lo\u1ea1n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u00fat xoang, block xoang \u2013 nh\u0129 ho\u1eb7c block nh\u0129 \u2013 th\u1ea5t \u0111\u1ed9 III<\/p>\n<p>Suy tim c\u1ea5p ho\u1eb7c kh\u00f4ng \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>B\u1ec7nh nh\u00e2n ph\u1ee5 thu\u1ed9c m\u00e1y t\u1ea1o nh\u1ecbp (nh\u1ecbp tim ho\u00e0n to\u00e0n ph\u1ee5 thu\u1ed9c m\u00e1y).<\/p>\n<p>\u0110au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai, \u0111ang nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9 hay nh\u1eefng ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u1ebfu kh\u00f4ng d\u00f9ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai th\u00edch h\u1ee3p.<\/p>\n<p>Ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (ketoconazol, itraconazol, clarithromycin, erythromycin \u0111\u01b0\u1eddng u\u1ed1ng, josamycin, telithromycin, nelfinavir, ritonavir, nefazodon).<\/p>\n<p>Ph\u1ed1i h\u1ee3p v\u1edbi verapamil ho\u1eb7c diltiazem (\u1ee9c ch\u1ebf trung b\u00ecnh CYP3A4 v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m ch\u1eadm nh\u1ecbp tim).<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>B\u1ec7nh nh\u00e2n huy\u1ebft \u00e1p th\u1ea5p: d\u1eef li\u1ec7u c\u00f2n h\u1ea1n ch\u1ebf tr\u00ean nh\u00f3m huy\u1ebft \u00e1p th\u1ea5p nh\u1eb9\u2013trung b\u00ecnh; ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh n\u1ebfu huy\u1ebft \u00e1p &lt; 90\/50 mmHg.<\/p>\n<p>Rung nh\u0129\/lo\u1ea1n nh\u1ecbp: thi\u1ebfu d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7, c\u1ea7n c\u00e2n nh\u1eafc khi thay \u0111\u1ed5i thu\u1ed1c.<\/p>\n<p>H\u1ed9i ch\u1ee9ng QT b\u1ea9m sinh ho\u1eb7c \u0111ang d\u00f9ng thu\u1ed1c k\u00e9o d\u00e0i QT: tr\u00e1nh ph\u1ed1i h\u1ee3p, do ivabradine c\u00f3 th\u1ec3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam k\u00e9o d\u00e0i kho\u1ea3ng QT d\u1eabn \u0111\u1ebfn nguy c\u01a1 lo\u1ea1n nh\u1ecbp n\u1eb7ng (xo\u1eafn \u0111\u1ec9nh).<\/p>\n<p>T\u0103ng huy\u1ebft \u00e1p: c\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p \u0111\u1ecbnh k\u1ef3, \u0111\u1eb7c bi\u1ec7t sau khi thay \u0111\u1ed5i \u0111i\u1ec1u tr\u1ecb thu\u1ed1c h\u1ea1 \u00e1p, do c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u01a1n t\u0103ng huy\u1ebft \u00e1p tho\u00e1ng qua.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t th\u01b0\u1eddng g\u1eb7p: C\u1ea3m gi\u00e1c l\u00f3e s\u00e1ng ho\u1eb7c ch\u00f3i m\u1eaft (phosphenes).<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Nh\u1ecbp tim ch\u1eadm, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t li\u00ean quan \u0111\u1ebfn t\u00ecnh tr\u1ea1ng nh\u1ecbp ch\u1eadm, kh\u00f3 m\u1edf m\u1eaft, huy\u1ebft \u00e1p ch\u01b0a ki\u1ec3m so\u00e1t.<\/p>\n<p>\u00cdt g\u1eb7p: \u0110\u00e1nh tr\u1ed1ng ng\u1ef1c, r\u1ed1i lo\u1ea1n nh\u1ecbp ngo\u1ea1i t\u00e2m thu tr\u00ean th\u1ea5t, h\u1ea1 huy\u1ebft \u00e1p, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a (bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng), ng\u1ea5t, t\u0103ng acid uric, ph\u00f9 m\u1ea1ch, ph\u00e1t ban, nh\u00ecn \u0111\u00f4i, gi\u1ea3m th\u1ecb l\u1ef1c, m\u1ea5t th\u0103ng b\u1eb1ng, chu\u1ed9t r\u00fat, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, kh\u00f4 h\u1ecdng, t\u0103ng creatinin huy\u1ebft, k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Ban \u0111\u1ecf, vi\u00eam da, n\u1ed5i m\u1ec1 \u0111ay, c\u1ea3m gi\u00e1c b\u1ea5t an.<\/p>\n<p>R\u1ea5t hi\u1ebfm g\u1eb7p: Xu\u1ea5t hi\u1ec7n rung nh\u0129, block nh\u0129 th\u1ea5t \u0111\u1ed9 II \u2013 III, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00fat xoang.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p><em><strong>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/strong><\/em><\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o ph\u1ed1i h\u1ee3p: V\u1edbi c\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT nh\u01b0 quinidin, disopyramid, bepridil, sotalol, ibutilid, amiodaron, pimozid, ziprasidon, sertindol, mefloquin, halofantrin, pentamidin, cisaprid, erythromycin ti\u00eam truy\u1ec1n. N\u1ebfu b\u1eaft bu\u1ed9c d\u00f9ng chung, c\u1ea7n theo d\u00f5i s\u00e1t ho\u1ea1t \u0111\u1ed9ng tim m\u1ea1ch.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p: V\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m kali huy\u1ebft.<\/p>\n<p><em><strong>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/strong><\/em><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi: V\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 g\u1ed3m kh\u00e1ng n\u1ea5m azole (ketoconazol, itraconazol), kh\u00e1ng sinh nh\u00f3m macrolid \u0111\u01b0\u1eddng u\u1ed1ng (clarithromycin, erythromycin, josamycin, telithromycin), thu\u1ed1c \u1ee9c ch\u1ebf protease HIV (nelfinavir, ritonavir) v\u00e0 nefazodon.<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o ph\u1ed1i h\u1ee3p: Ch\u1ea5t \u1ee9c ch\u1ebf m\u1ee9c \u0111\u1ed9 v\u1eeba CYP3A4 (diltiazem, verapamil,&#8230;)<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p: V\u1edbi fluconazol, n\u01b0\u1edbc \u00e9p b\u01b0\u1edfi, ho\u1eb7c c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 (rifampicin, barbiturat, phenytoin, th\u1ea3o d\u01b0\u1ee3c St. John\u2019s Wort).<\/p>\n<p>C\u00e1c t\u01b0\u01a1ng t\u00e1c kh\u00e1c: Nh\u1eefng nghi\u00ean c\u1ee9u chuy\u00ean bi\u1ec7t cho th\u1ea5y Ivabradine kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u2013 d\u01b0\u1ee3c l\u1ef1c h\u1ecdc c\u1ee7a c\u00e1c thu\u1ed1c nh\u01b0 omeprazol, lansoprazol, sildenafil, simvastatin, amlodipin, lacidipin, digoxin v\u00e0 warfarin. \u0110\u1ed3ng th\u1eddi, ivabradine c\u0169ng kh\u00f4ng l\u00e0m thay \u0111\u1ed5i t\u00e1c d\u1ee5ng c\u1ee7a aspirin.<\/p>\n<p>L\u01b0u \u00fd \u1edf tr\u1ebb em: C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u01b0\u01a1ng t\u00e1c m\u1edbi ch\u1ec9 th\u1ef1c hi\u1ec7n tr\u00ean ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai: C\u1ea7n \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai an to\u00e0n trong su\u1ed1t th\u1eddi gian s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n<p>Th\u1eddi k\u1ef3 mang thai: Ivabradine ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho ph\u1ee5 n\u1eef \u0111ang mang thai.<\/p>\n<p>Th\u1eddi k\u1ef3 cho con b\u00fa: Khi c\u1ea7n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ivabradine, n\u00ean ng\u1eebng cho con b\u00fa v\u00e0 ch\u1ecdn h\u00ecnh th\u1ee9c nu\u00f4i d\u01b0\u1ee1ng kh\u00e1c.<\/p>\n<p>Kh\u1ea3 n\u0103ng sinh s\u1ea3n: D\u1eef li\u1ec7u tr\u00ean \u0111\u1ed9ng v\u1eadt th\u00ed nghi\u1ec7m (chu\u1ed9t) cho th\u1ea5y kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi ch\u1ee9c n\u0103ng sinh s\u1ea3n \u1edf c\u1ea3 gi\u1ed1ng \u0111\u1ef1c v\u00e0 gi\u1ed1ng c\u00e1i.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ivabradine c\u00f3 th\u1ec3 g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng l\u00f3e s\u00e1ng tho\u00e1ng qua, \u0111\u1eb7c bi\u1ec7t khi thay \u0111\u1ed5i \u00e1nh s\u00e1ng \u0111\u1ed9t ng\u1ed9t. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng quan s\u00e1t, nh\u1ea5t l\u00e0 khi l\u00e1i xe ban \u0111\u00eam. Tuy nhi\u00ean, ngo\u00e0i hi\u1ec7n t\u01b0\u1ee3ng tr\u00ean, thu\u1ed1c kh\u00f4ng l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u ivabradine c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng nh\u1ecbp tim ch\u1eadm k\u00e9o d\u00e0i v\u00e0 h\u1ea1 huy\u1ebft \u00e1p. Trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y, c\u1ea7n \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng, c\u00f3 th\u1ec3 d\u00f9ng c\u00e1c thu\u1ed1c k\u00edch th\u00edch beta ho\u1eb7c atropin n\u1ebfu c\u1ea7n thi\u1ebft. Nh\u1eefng t\u00ecnh hu\u1ed1ng nghi\u00eam tr\u1ecdng c\u1ea7n theo d\u00f5i tim m\u1ea1ch li\u00ean t\u1ee5c cho t\u1edbi khi ng\u01b0\u1eddi b\u1ec7nh \u1ed5n \u0111\u1ecbnh.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Savi Ivabradine 5 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Savi Ivabradine 5 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Savi Ivabradine 5 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Savi Ivabradine 5 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/bixebra-5mg\/\">Bixebra 5mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Ivabradine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 5mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi KRKA, D.D., . Novo Mesto, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb \u0111au th\u1eaft ng\u1ef1c m\u1ea1n t\u00ednh<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/ivaswift-5\/\">Ivaswift 5<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Ivabradine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 5mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Ind-Swift Limited, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb \u0111au th\u1eaft ng\u1ef1c m\u1ea1n t\u00ednh<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Sathyamurthy I, Newale S (2018). Ivabradine: Evidence and current role in cardiovascular diseases and other emerging indications. Indian Heart J. Truy c\u1eadp ng\u00e0y 29 th\u00e1ng 8 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6309574\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6309574\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Savi Ivabradine 5 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m gi\u1ea3m t\u1ea7n s\u1ed1 tim, h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh v\u00e0 suy tim m\u1ea1n t\u00ednh \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng.<\/span><\/p>\n","protected":false},"author":1,"featured_media":136008,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-136007","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/136007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=136007"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/136008"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=136007"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=136007"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=136007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}