{"id":135693,"date":"2025-08-28T12:26:19","date_gmt":"2025-08-28T05:26:19","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=135693"},"modified":"2026-01-04T13:02:37","modified_gmt":"2026-01-04T06:02:37","slug":"sifrol-0-25mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/sifrol-0-25mg\/","title":{"rendered":"Sifrol 0.25mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Sifrol 0.25mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH &amp; Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-20132-16.<\/strong><\/p>\n<h2>Sifrol 0.25mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Sifrol 0.25mg<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c k\u00ea \u0111\u01a1n thu\u1ed9c nh\u00f3m ch\u1ea5t ch\u1ee7 v\u1eadn dopamin, c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: <strong>Pramipexole<\/strong> dihydrochloride monohydrate 0.25mg (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 0.18mg Pramipexole d\u1ea1ng baz\u01a1).<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Mannitol, tinh b\u1ed9t ng\u00f4, silica khan d\u1ea1ng keo, polyvidon, magie stearat.<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-20132-16<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Germany<\/p>\n<figure id=\"attachment_135694\" aria-describedby=\"caption-attachment-135694\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-135694\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Sifrol-0.25mg.jpg\" alt=\"Sifrol 0.25mg \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Parkinson v\u00f4 c\u0103n\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Sifrol-0.25mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Sifrol-0.25mg-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Sifrol-0.25mg-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Sifrol-0.25mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-135694\" class=\"wp-caption-text\">Sifrol 0.25mg \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Parkinson v\u00f4 c\u0103n<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Sifrol 0.25mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Pramipexole l\u00e0 m\u1ed9t ch\u1ea5t ch\u1ee7 v\u1eadn dopamin kh\u00f4ng ergoline, ho\u1ea1t \u0111\u1ed9ng v\u1edbi \u00e1i l\u1ef1c cao v\u00e0 t\u00ednh ch\u1ecdn l\u1ecdc v\u01b0\u1ee3t tr\u1ed9i tr\u00ean ph\u00e2n nh\u00f3m th\u1ee5 th\u1ec3 dopamin D2, \u0111\u1eb7c bi\u1ec7t l\u00e0 th\u1ee5 th\u1ec3 D3. C\u01a1 ch\u1ebf c\u1ed1t l\u00f5i c\u1ee7a Pramipexole trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Parkinson l\u00e0 k\u00edch th\u00edch tr\u1ef1c ti\u1ebfp c\u00e1c th\u1ee5 th\u1ec3 dopamin trong th\u1ec3 v\u00e2n (striatum) c\u1ee7a n\u00e3o. \u1ede b\u1ec7nh nh\u00e2n Parkinson, c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh s\u1ea3n xu\u1ea5t dopamin b\u1ecb tho\u00e1i h\u00f3a v\u00e0 ch\u1ebft \u0111i, d\u1eabn \u0111\u1ebfn s\u1ef1 thi\u1ebfu h\u1ee5t nghi\u00eam tr\u1ecdng ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh n\u00e0y, g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1eadn \u0111\u1ed9ng \u0111i\u1ec3n h\u00ecnh nh\u01b0 run, c\u1ee9ng c\u01a1, v\u00e0 v\u1eadn \u0111\u1ed9ng ch\u1eadm ch\u1ea1p. Pramipexole b\u00f9 \u0111\u1eafp s\u1ef1 thi\u1ebfu h\u1ee5t n\u00e0y b\u1eb1ng c\u00e1ch &#8220;b\u1eaft ch\u01b0\u1edbc&#8221; t\u00e1c d\u1ee5ng c\u1ee7a dopamin t\u1ef1 nhi\u00ean, gi\u00fap ph\u1ee5c h\u1ed3i c\u00e2n b\u1eb1ng d\u1eabn truy\u1ec1n th\u1ea7n kinh v\u00e0 l\u00e0m gi\u1ea3m b\u1edbt c\u00e1c khi\u1ebfm khuy\u1ebft v\u1eadn \u0111\u1ed9ng. \u0110\u1ed1i v\u1edbi H\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng y\u00ean, c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m s\u00e1ng t\u1ecf ho\u00e0n to\u00e0n nh\u01b0ng c\u0169ng \u0111\u01b0\u1ee3c cho l\u00e0 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u h\u00f2a h\u1ec7 th\u1ed1ng dopaminergic.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Pramipexole \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n sau khi u\u1ed1ng, v\u1edbi sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i tr\u00ean 90%. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 1-3 gi\u1edd. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 h\u1ea5p thu nh\u01b0ng c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm t\u1ed1c \u0111\u1ed9 h\u1ea5p thu.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c c\u00f3 t\u1ef7 l\u1ec7 li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng r\u1ea5t th\u1ea5p (&lt;20%) v\u00e0 c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn (kho\u1ea3ng 400L), cho ph\u00e9p thu\u1ed1c th\u00e2m nh\u1eadp t\u1ed1t v\u00e0o c\u00e1c m\u00f4, bao g\u1ed3m c\u1ea3 m\u00f4 n\u00e3o.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Pramipexole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ea5t \u00edt trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i (kho\u1ea3ng 90%). \u0110\u1ed9 thanh th\u1ea3i to\u00e0n ph\u1ea7n kho\u1ea3ng 500 mL\/ph\u00fat. Th\u1eddi gian b\u00e1n th\u1ea3i (t1\/2) dao \u0111\u1ed9ng t\u1eeb 8 gi\u1edd \u1edf ng\u01b0\u1eddi tr\u1ebb \u0111\u1ebfn 12 gi\u1edd \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n<h2>Thu\u1ed1c Sifrol 0.25mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>B\u1ec7nh Parkinson t\u1ef1 ph\u00e1t: \u0110i\u1ec1u tr\u1ecb c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh. Thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u01a1n tr\u1ecb li\u1ec7u \u1edf giai \u0111o\u1ea1n s\u1edbm ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi levodopa \u1edf giai \u0111o\u1ea1n mu\u1ed9n h\u01a1n, \u0111\u1eb7c bi\u1ec7t khi hi\u1ec7u qu\u1ea3 c\u1ee7a levodopa suy gi\u1ea3m ho\u1eb7c xu\u1ea5t hi\u1ec7n c\u00e1c dao \u0111\u1ed9ng v\u1eadn \u0111\u1ed9ng (&#8220;wear-off&#8221; ho\u1eb7c &#8220;on-off&#8221;).<\/li>\n<li>H\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng y\u00ean (Restless Legs Syndrome &#8211; RLS): \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng cho RLS v\u00f4 c\u0103n \u1edf m\u1ee9c \u0111\u1ed9 t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Sifrol 0.25mg<\/h2>\n<p>Li\u1ec1u d\u00f9ng ph\u1ea3i \u0111\u01b0\u1ee3c c\u00e1 th\u1ec3 h\u00f3a v\u00e0 t\u0103ng t\u1eeb t\u1eeb (d\u00f2 li\u1ec1u) d\u01b0\u1edbi s\u1ef1 theo d\u00f5i c\u1ee7a b\u00e1c s\u0129. Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng t\u1ef1 \u00fd thay \u0111\u1ed5i li\u1ec1u.<\/p>\n<ul>\n<li>\u0110\u1ed1i v\u1edbi b\u1ec7nh Parkinson:\n<ul>\n<li>Kh\u1edfi \u0111\u1ea7u: Li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 0.125mg x 3 l\u1ea7n\/ng\u00e0y (t\u1ed5ng 0.375mg\/ng\u00e0y). Li\u1ec1u \u0111\u01b0\u1ee3c t\u0103ng d\u1ea7n m\u1ed7i 5-7 ng\u00e0y, tu\u1ea7n t\u1ef1 l\u00ean 0.25mg x 3 l\u1ea7n\/ng\u00e0y, sau \u0111\u00f3 l\u00e0 0.5mg x 3 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Duy tr\u00ec: Li\u1ec1u \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 th\u01b0\u1eddng n\u1eb1m trong kho\u1ea3ng 1.5mg \u0111\u1ebfn 4.5mg m\u1ed7i ng\u00e0y, chia l\u00e0m 3 l\u1ea7n. Vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng v\u00e0 s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a t\u00e1c d\u1ee5ng ph\u1ee5.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn: C\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng d\u1ef1a tr\u00ean \u0111\u1ed9 thanh th\u1ea3i creatinin (CrCl). B\u1ec7nh nh\u00e2n c\u00f3 CrCl &lt; 50 mL\/ph\u00fat c\u1ea7n gi\u1ea3m li\u1ec1u theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/li>\n<\/ul>\n<\/li>\n<li>\u0110\u1ed1i v\u1edbi H\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng y\u00ean:\n<ul>\n<li>Kh\u1edfi \u0111\u1ea7u: Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 0.125mg, u\u1ed1ng 1 l\u1ea7n duy nh\u1ea5t kho\u1ea3ng 2-3 gi\u1edd tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/li>\n<li>D\u00f2 li\u1ec1u: N\u1ebfu c\u1ea7n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u sau m\u1ed7i 4-7 ng\u00e0y l\u00ean 0.25mg, 0.5mg, v\u00e0 t\u1ed1i \u0111a l\u00e0 0.75mg m\u1ed7i ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Sifrol 0.25mg<\/h2>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng qua \u0111\u01b0\u1eddng u\u1ed1ng, nu\u1ed1t nguy\u00ean vi\u00ean v\u1edbi m\u1ed9t ly n\u01b0\u1edbc.<\/p>\n<p>C\u00f3 th\u1ec3 u\u1ed1ng Sifrol 0.25mg c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh Parkinson, t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y \u0111\u01b0\u1ee3c chia \u0111\u1ec1u l\u00e0m 3 l\u1ea7n u\u1ed1ng.<\/p>\n<p>\u0110\u1ed1i v\u1edbi H\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng y\u00ean, u\u1ed1ng 1 li\u1ec1u duy nh\u1ea5t v\u00e0o bu\u1ed5i t\u1ed1i.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Sifrol 0.25mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh tuy\u1ec7t \u0111\u1ed1i \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi Pramipexole ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Sifrol 0.25mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng Sifrol 0.25mg \u0111\u00f2i h\u1ecfi s\u1ef1 th\u1eadn tr\u1ecdng cao do nguy c\u01a1 x\u1ea3y ra c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nghi\u00eam tr\u1ecdng tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. B\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi nh\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea5u hi\u1ec7u sau:<\/p>\n<ul>\n<li>&#8220;R\u1ed1i lo\u1ea1n ki\u1ec3m so\u00e1t xung \u0111\u1ed9ng&#8221; (Impulse Control Disorders &#8211; ICDs): \u0110\u00e2y l\u00e0 m\u1ed9t c\u1ea3nh b\u00e1o r\u1ea5t quan tr\u1ecdng. B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c h\u00e0nh vi b\u1ea5t th\u01b0\u1eddng, kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c nh\u01b0 c\u1edd b\u1ea1c b\u1ec7nh l\u00fd, t\u0103ng ham mu\u1ed1n t\u00ecnh d\u1ee5c (hypersexuality), mua s\u1eafm v\u00e0 \u0103n u\u1ed1ng v\u00f4 \u0111\u1ed9. Nh\u1eefng h\u00e0nh vi n\u00e0y c\u00f3 th\u1ec3 g\u00e2y h\u1eadu qu\u1ea3 nghi\u00eam tr\u1ecdng v\u1ec1 t\u00e0i ch\u00ednh v\u00e0 x\u00e3 h\u1ed9i. C\u1ea7n xem x\u00e9t gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u01b0ng thu\u1ed1c n\u1ebfu c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y xu\u1ea5t hi\u1ec7n.<\/li>\n<li>&#8220;C\u01a1n bu\u1ed3n ng\u1ee7 v\u00e0 ng\u1ee7 g\u1eadt \u0111\u1ed9t ng\u1ed9t&#8221; (Sudden Onset of Sleep): B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 tr\u1ea3i qua c\u01a1n bu\u1ed3n ng\u1ee7 d\u1eef d\u1ed9i v\u00e0 ng\u1ee7 thi\u1ebfp \u0111i \u0111\u1ed9t ng\u1ed9t m\u00e0 kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u b\u00e1o tr\u01b0\u1edbc, ngay c\u1ea3 khi \u0111ang th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng h\u00e0ng ng\u00e0y nh\u01b0 n\u00f3i chuy\u1ec7n, \u0103n u\u1ed1ng, ho\u1eb7c th\u1eadm ch\u00ed l\u00e0 l\u00e1i xe. \u0110\u00e2y l\u00e0 m\u1ed9t nguy c\u01a1 c\u1ef1c k\u1ef3 nguy hi\u1ec3m.<\/li>\n<li>\u1ea2o gi\u00e1c: \u1ea2o gi\u00e1c (ch\u1ee7 y\u1ebfu l\u00e0 \u1ea3o th\u1ecb) l\u00e0 m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 khi d\u00f9ng li\u1ec1u cao. B\u1ec7nh nh\u00e2n c\u0169ng c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i t\u00ecnh tr\u1ea1ng l\u00fa l\u1eabn, m\u00ea s\u1ea3ng ho\u1eb7c hoang t\u01b0\u1edfng.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t th\u01b0\u1eddng g\u1eb7p (\u2265 1\/10): Bu\u1ed3n n\u00f4n, ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng (khi ph\u1ed1i h\u1ee3p v\u1edbi levodopa), h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p (\u2265 1\/100 \u0111\u1ebfn &lt; 1\/10): M\u01a1 b\u1ea5t th\u01b0\u1eddng, l\u00fa l\u1eabn, \u1ea3o gi\u00e1c, m\u1ea5t ng\u1ee7, bu\u1ed3n ng\u1ee7, \u0111au \u0111\u1ea7u, t\u00e1o b\u00f3n, m\u1ec7t m\u1ecfi, ph\u00f9 ngo\u1ea1i bi\u00ean.<\/p>\n<p>Kh\u00e1c: C\u00e1c h\u00e0nh vi b\u1ea5t th\u01b0\u1eddng (ICDs), suy gi\u1ea3m th\u1ecb l\u1ef1c, n\u1ea5c, kh\u00f3 th\u1edf, ng\u1ee9a, ph\u00e1t ban, t\u0103ng ho\u1eb7c gi\u1ea3m c\u00e2n.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft qua \u1ed1ng th\u1eadn (v\u00ed d\u1ee5: cimetidin, amantadin) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a Pramipexole, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n (v\u00ed d\u1ee5: haloperidol, risperidone) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a Sifrol do c\u01a1 ch\u1ebf \u0111\u1ed1i kh\u00e1ng t\u1ea1i th\u1ee5 th\u1ec3 dopamin.<\/p>\n<p>R\u01b0\u1ee3u v\u00e0 c\u00e1c thu\u1ed1c an th\u1ea7n kh\u00e1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng g\u00e2y bu\u1ed3n ng\u1ee7 c\u1ee7a Sifrol.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u tr\u00ean ng\u01b0\u1eddi. Ch\u1ec9 s\u1eed d\u1ee5ng khi l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1 ti\u1ec1m \u1ea9n cho thai nhi.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng. Sifrol \u1ee9c ch\u1ebf ti\u1ebft prolactin, c\u00f3 th\u1ec3 l\u00e0m m\u1ea5t s\u1eefa. Thu\u1ed1c c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Sifrol 0.25mg c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, do nguy c\u01a1 g\u00e2y bu\u1ed3n ng\u1ee7 v\u00e0 ng\u1ee7 g\u1eadt \u0111\u1ed9t ng\u1ed9t kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u b\u00e1o tr\u01b0\u1edbc, b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Sifrol tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, ho\u1eb7c tham gia v\u00e0o b\u1ea5t k\u1ef3 ho\u1ea1t \u0111\u1ed9ng n\u00e0o \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o cho \u0111\u1ebfn khi x\u00e1c \u0111\u1ecbnh r\u00f5 thu\u1ed1c kh\u00f4ng c\u00f2n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u00ecnh.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng: Bu\u1ed3n n\u00f4n, n\u00f4n, t\u0103ng \u0111\u1ed9ng, \u1ea3o gi\u00e1c, k\u00edch \u0111\u1ed9ng v\u00e0 h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n<p>X\u1eed tr\u00ed: Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. Bi\u1ec7n ph\u00e1p x\u1eed tr\u00ed ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed7 tr\u1ee3, c\u00f3 th\u1ec3 bao g\u1ed3m r\u1eeda d\u1ea1 d\u00e0y, truy\u1ec1n d\u1ecbch, d\u00f9ng than ho\u1ea1t v\u00e0 theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c Sifrol 0.25mg \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C, n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp. \u0110\u1ec3 xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Sifrol 0.25mg<\/h2>\n<p>Tr\u00ean th\u1ecb tr\u01b0\u1eddng c\u00f3 m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c ch\u1ee9a ho\u1ea1t ch\u1ea5t Pramipexole, trong \u0111\u00f3 c\u00f3 thu\u1ed1c <a href=\"https:\/\/vnras.com\/drug\/oprymea-0-26-mg\/\">Oprymea 0.26mg<\/a>.<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t v\u00e0 h\u00e0m l\u01b0\u1ee3ng: Oprymea 0.26mg ch\u1ee9a Pramipexole d\u01b0\u1edbi d\u1ea1ng Pramipexole dihydrochloride monohydrate. \u0110i\u1ec1u quan tr\u1ecdng c\u1ea7n l\u01b0u \u00fd l\u00e0 h\u00e0m l\u01b0\u1ee3ng 0.26mg mu\u1ed1i c\u1ee7a Oprymea t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 0.18mg Pramipexole d\u1ea1ng baz\u01a1, ho\u00e0n to\u00e0n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1ec1 m\u1eb7t d\u01b0\u1ee3c ch\u1ea5t v\u1edbi Sifrol 0.25mg (ch\u1ee9a 0.25mg mu\u1ed1i t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 0.18mg baz\u01a1).<\/li>\n<li>Nh\u00e0 s\u1ea3n xu\u1ea5t: KRKA, d.d., Novo mesto (Slovenia).<\/li>\n<li>Ch\u1ec9 \u0111\u1ecbnh v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: T\u01b0\u01a1ng t\u1ef1 nh\u01b0 Sifrol, \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Parkinson v\u00e0 H\u1ed9i ch\u1ee9ng ch\u00e2n kh\u00f4ng y\u00ean.<\/li>\n<li>Do c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 h\u00e0m l\u01b0\u1ee3ng baz\u01a1 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i gi\u1eefa Sifrol v\u00e0 Oprymea ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ec9 d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Don Chamith Halahakoon, Michael Browning. Pramipexole for the Treatment of Depression: Efficacy and Mechanisms, truy c\u1eadp ng\u00e0y 28 th\u00e1ng 08 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37982928\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37982928\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Sifrol 0.25mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH &amp; Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-20132-16, \u0111i\u1ec1u tr\u1ecb d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng Parkinson v\u00f4 c\u0103n.<\/p>\n","protected":false},"author":1,"featured_media":135695,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-135693","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/135693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=135693"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/135695"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=135693"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=135693"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=135693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}