{"id":135084,"date":"2025-08-26T13:22:49","date_gmt":"2025-08-26T06:22:49","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=135084"},"modified":"2025-08-26T13:28:34","modified_gmt":"2025-08-26T06:28:34","slug":"glucophage-500mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/glucophage-500mg\/","title":{"rendered":"Glucophage 500mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Glucophage 500mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Merck Sante s.a.s. c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 300110016124 (S\u0110K c\u0169: VN-21993-19)<\/strong><\/p>\n<h2>Glucophage 500mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Glucophage 500mg<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: Metformin hydroclorid 500mg (t\u01b0\u01a1ng \u1ee9ng 390mg metformin base).<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Polyvidone K30, magnesium stearate, hypromellose.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 300110016124 (S\u0110K c\u0169: VN-21993-19)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Ph\u00e1p<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 60 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Glucophage 500mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Metformin l\u00e0 thu\u1ed1c thu\u1ed9c nh\u00f3m biguanid, c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 glucose huy\u1ebft t\u01b0\u01a1ng khi \u0111\u00f3i c\u0169ng nh\u01b0 sau \u0103n m\u00e0 kh\u00f4ng k\u00edch th\u00edch tuy\u1ebfn t\u1ee5y t\u0103ng ti\u1ebft insulin, do \u0111\u00f3 h\u1ea1n ch\u1ebf nguy c\u01a1 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft. T\u00e1c \u0111\u1ed9ng ch\u00ednh c\u1ee7a thu\u1ed1c g\u1ed3m:<\/p>\n<ul>\n<li>\u1ee8c ch\u1ebf qu\u00e1 tr\u00ecnh t\u00e2n t\u1ea1o \u0111\u01b0\u1eddng v\u00e0 ph\u00e2n gi\u1ea3i glycogen \u1edf gan, t\u1eeb \u0111\u00f3 gi\u1ea3m s\u1ea3n xu\u1ea5t glucose.<\/li>\n<li>Gi\u1ea3m h\u1ea5p thu glucose t\u1ea1i ru\u1ed9t.<\/li>\n<li>T\u0103ng nh\u1ea1y c\u1ea3m c\u1ee7a m\u00f4 ngo\u1ea1i vi (\u0111\u1eb7c bi\u1ec7t l\u00e0 c\u01a1) v\u1edbi insulin, c\u1ea3i thi\u1ec7n s\u1eed d\u1ee5ng glucose.<\/li>\n<\/ul>\n<p>Ngo\u00e0i ra, metformin th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p glycogen nh\u1edd t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn enzym glycogen synthase, \u0111\u1ed3ng th\u1eddi t\u0103ng c\u01b0\u1eddng v\u1eadn chuy\u1ec3n glucose v\u00e0o trong t\u1ebf b\u00e0o qua c\u00e1c k\u00eanh v\u1eadn chuy\u1ec3n GLUT. Thu\u1ed1c c\u00f3 th\u1ec3 gi\u00fap b\u1ec7nh nh\u00e2n gi\u1eef c\u00e2n n\u1eb7ng \u1ed5n \u0111\u1ecbnh ho\u1eb7c gi\u1ea3m nh\u1eb9 c\u00e2n, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a lipid (gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n, LDL-C v\u00e0 triglycerid).<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Sau khi u\u1ed1ng, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t sau kho\u1ea3ng 2,5 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 50\u201360%. Kho\u1ea3ng 20\u201330% l\u01b0\u1ee3ng thu\u1ed1c u\u1ed1ng kh\u00f4ng \u0111\u01b0\u1ee3c h\u1ea5p thu s\u1ebd \u0111\u00e0o th\u1ea3i qua ph\u00e2n. Th\u1ee9c \u0103n l\u00e0m ch\u1eadm v\u00e0 gi\u1ea3m h\u1ea5p thu \u1edf m\u1ee9c kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/p>\n<p>Ph\u00e2n b\u1ed1: T\u1ef7 l\u1ec7 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng r\u1ea5t th\u1ea5p. Thu\u1ed1c ph\u00e2n b\u1ed1 v\u00e0o h\u1ed3ng c\u1ea7u, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 dao \u0111\u1ed9ng t\u1eeb 63\u2013276 l\u00edt.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Metformin kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a \u1edf ng\u01b0\u1eddi, th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng nguy\u00ean v\u1eb9n qua th\u1eadn.<\/p>\n<p>Th\u1ea3i tr\u1eeb: <span style=\"font-size: 14.4px;\">Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a metformin c\u00f3 trong vi\u00ean n\u00e9n Glucophage x\u1ea5p x\u1ec9 6,5 gi\u1edd<\/span><span style=\"font-size: 14.4px;\">. \u0110\u1ed9 thanh th\u1ea3i v\u01b0\u1ee3t qu\u00e1 400 ml\/ph\u00fat, ch\u1ee9ng t\u1ecf \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i nh\u1edd l\u1ecdc c\u1ea7u th\u1eadn v\u00e0 b\u00e0i ti\u1ebft \u1edf \u1ed1ng th\u1eadn. \u1ede b\u1ec7nh nh\u00e2n suy th\u1eadn, kh\u1ea3 n\u0103ng th\u1ea3i tr\u1eeb gi\u1ea3m, th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i v\u00e0 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u t\u0103ng.<\/span><\/p>\n<p>\u0110\u1eb7c \u0111i\u1ec3m theo nh\u00f3m b\u1ec7nh nh\u00e2n: \u1ede tr\u1ebb em sau li\u1ec1u \u0111\u01a1n 500 mg, \u0111\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc t\u01b0\u01a1ng t\u1ef1 ng\u01b0\u1eddi l\u1edbn. Khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong gi\u1ea3m 33\u201340% so v\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh.<\/p>\n<h2>Thu\u1ed1c Glucophage 500mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 c\u00e2n n\u1eb7ng d\u01b0 th\u1eeba khi ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 t\u1eadp luy\u1ec7n kh\u00f4ng \u0111\u1ee7 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p>S\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn \u0111\u01a1n tr\u1ecb ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, bao g\u1ed3m insulin.<\/p>\n<p>D\u00f9ng cho tr\u1ebb t\u1eeb 10 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 thanh thi\u1ebfu ni\u00ean, c\u00f3 th\u1ec3 \u0111\u01a1n tr\u1ecb ho\u1eb7c k\u1ebft h\u1ee3p insulin.<\/p>\n<figure id=\"attachment_135109\" aria-describedby=\"caption-attachment-135109\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-135109\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg.jpg\" alt=\"Glucophage 500mg\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Glucophage-500mg-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-135109\" class=\"wp-caption-text\">Thu\u1ed1c Glucophage 500mg l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2 ch\u1ee9a Metformin, d\u00f9ng \u0111\u01a1n tr\u1ecb ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, k\u1ec3 c\u1ea3 insulin<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Ng\u01b0\u1eddi l\u1edbn (ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, eGFR \u2265 90 mL\/ph\u00fat\/1,73m\u00b2):<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u 500 mg u\u1ed1ng 2\u20133 l\u1ea7n\/ng\u00e0y trong ho\u1eb7c sau b\u1eefa \u0103n. C\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh sau 10\u201315 ng\u00e0y d\u1ef1a v\u00e0o \u0111\u01b0\u1eddng huy\u1ebft. Li\u1ec1u t\u1ed1i \u0111a 3 g\/ng\u00e0y chia 3 l\u1ea7n.<\/p>\n<p>Khi ph\u1ed1i h\u1ee3p v\u1edbi insulin: <span style=\"font-size: 14.4px;\">Metformin kh\u1edfi \u0111\u1ea7u 500 mg 2\u20133 l\u1ea7n\/ng\u00e0y. Li\u1ec1u insulin ch\u1ec9nh theo \u0111\u01b0\u1eddng huy\u1ebft.<\/span><\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/p>\n<ul>\n<li>eGFR 60\u201389: c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u.<\/li>\n<li>eGFR 30\u201359: d\u00f9ng khi kh\u00f4ng c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c. Li\u1ec1u kh\u1edfi \u0111\u1ea7u 500 mg\/ng\u00e0y, t\u1ed1i \u0111a 1000 mg\/ng\u00e0y.<\/li>\n<li>eGFR &lt;30: ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<\/ul>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: c\u1ea7n ch\u1ec9nh li\u1ec1u theo ch\u1ee9c n\u0103ng th\u1eadn, ki\u1ec3m tra th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p>Tr\u1ebb em \u226510 tu\u1ed5i: kh\u1edfi \u0111\u1ea7u 500 mg\/ng\u00e0y, sau 10\u201315 ng\u00e0y \u0111i\u1ec1u ch\u1ec9nh t\u00f9y \u0111\u01b0\u1eddng huy\u1ebft. Li\u1ec1u t\u1ed1i \u0111a 2 g\/ng\u00e0y chia 2\u20133 l\u1ea7n.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Nu\u1ed1t nguy\u00ean <strong>vi\u00ean n\u00e9n Glucophage 500mg<\/strong> trong ho\u1eb7c sau b\u1eefa \u0103n, kh\u00f4ng nhai hay nghi\u1ec1n. V\u00ed d\u1ee5 li\u1ec1u 2 vi\u00ean\/ng\u00e0y: u\u1ed1ng 1 vi\u00ean v\u00e0o b\u1eefa s\u00e1ng, 1 vi\u00ean v\u00e0o b\u1eefa t\u1ed1i.<br \/>\nD\u00f9ng li\u00ean t\u1ee5c h\u00e0ng ng\u00e0y. N\u1ebfu ng\u1eebng thu\u1ed1c c\u1ea7n tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Glucophage 500mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>D\u1ecb \u1ee9ng v\u1edbi metformin ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Glucophage 500mg<\/p>\n<p>\u0110ang b\u1ecb toan chuy\u1ec3n h\u00f3a c\u1ea5p t\u00ednh (nh\u01b0 nhi\u1ec5m toan lactic, toan ceton do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng) ho\u1eb7c ti\u1ec1n h\u00f4n m\u00ea do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng v\u1edbi eGFR &lt;30 mL\/ph\u00fat\/1,73m\u00b2.<\/p>\n<p>B\u1ec7nh c\u1ea5p t\u00ednh l\u00e0m thay \u0111\u1ed5i ch\u1ee9c n\u0103ng th\u1eadn (m\u1ea5t n\u01b0\u1edbc, nhi\u1ec5m tr\u00f9ng n\u1eb7ng, s\u1ed1c).<\/p>\n<p>B\u1ec7nh g\u00e2y thi\u1ebfu oxy m\u00f4: suy tim m\u1ea5t b\u00f9, suy h\u00f4 h\u1ea5p, nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p, s\u1ed1c.<\/p>\n<p>Suy gan<\/p>\n<p>Ng\u1ed9 \u0111\u1ed9c r\u01b0\u1ee3u c\u1ea5p<\/p>\n<p>Nghi\u1ec7n r\u01b0\u1ee3u.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Nguy c\u01a1 nhi\u1ec5m acid lactic: c\u00f3 th\u1ec3 g\u1eb7p hi\u1ebfm nh\u01b0ng nghi\u00eam tr\u1ecdng, th\u1eadm ch\u00ed t\u1eed vong. C\u1ea7n c\u1ea3nh gi\u00e1c \u1edf ng\u01b0\u1eddi suy th\u1eadn, suy gan, suy tim, u\u1ed1ng r\u01b0\u1ee3u, ng\u01b0\u1eddi \u226565 tu\u1ed5i, b\u1ec7nh c\u1ea5p t\u00ednh g\u00e2y thi\u1ebfu oxy, d\u00f9ng chung thu\u1ed1c \u1ea3nh h\u01b0\u1edfng th\u1eadn ho\u1eb7c acid-base, sau khi ti\u00eam thu\u1ed1c c\u1ea3n quang ch\u1ee9a iod, ho\u1eb7c trong ph\u1eabu thu\u1eadt l\u1edbn.<\/p>\n<p>Suy th\u1eadn: metformin th\u1ea3i tr\u1eeb qua th\u1eadn, c\u1ea7n ki\u1ec3m tra eGFR \u0111\u1ecbnh k\u1ef3. Kh\u00f4ng d\u00f9ng n\u1ebfu eGFR &lt;30. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u khi eGFR 30\u201359.<\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn tu\u1ed5i: theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean h\u01a1n.<\/p>\n<p>Ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh v\u1edbi thu\u1ed1c c\u1ea3n quang ch\u1ee9a iod: ng\u1eebng metformin tr\u01b0\u1edbc ho\u1eb7c t\u1ea1i th\u1eddi \u0111i\u1ec3m ti\u00eam n\u1ebfu eGFR 30\u201360 ho\u1eb7c c\u00f3 nguy c\u01a1 suy th\u1eadn. D\u00f9ng l\u1ea1i sau 48 gi\u1edd khi ch\u1ee9c n\u0103ng th\u1eadn \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>Ph\u1eabu thu\u1eadt g\u00e2y m\u00ea to\u00e0n th\u00e2n ho\u1eb7c t\u1ee7y s\u1ed1ng: ng\u1eebng metformin, ch\u1ec9 d\u00f9ng l\u1ea1i sau \u00edt nh\u1ea5t 48 gi\u1edd khi ch\u1ee9c n\u0103ng th\u1eadn \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>R\u01b0\u1ee3u: kh\u00f4ng u\u1ed1ng r\u01b0\u1ee3u trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00ec t\u0103ng nguy c\u01a1 acid lactic.<\/p>\n<p>Suy gan: ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh do l\u00e0m t\u0103ng t\u00edch l\u0169y lactate.<\/p>\n<p>Suy tim: ch\u1ec9 d\u00f9ng \u1edf suy tim \u1ed5n \u0111\u1ecbnh v\u00e0 c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd tim, th\u1eadn. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong suy tim c\u1ea5p ho\u1eb7c kh\u00f4ng ki\u1ec3m so\u00e1t.<\/p>\n<p>Tr\u1ebb em: c\u1ea7n x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c ch\u1ea9n \u0111o\u00e1n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2 tr\u01b0\u1edbc khi d\u00f9ng. Theo d\u00f5i t\u0103ng tr\u01b0\u1edfng, ph\u00e1t tri\u1ec3n v\u00e0 d\u1eady th\u00ec. V\u1edbi nh\u00f3m 10\u201312 tu\u1ed5i ch\u1ec9 n\u00ean d\u00f9ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 theo d\u00f5i c\u1ea9n th\u1eadn.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>R\u1ea5t th\u01b0\u1eddng g\u1eb7p: R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, ch\u00e1n \u0103n, \u0111au b\u1ee5ng; th\u01b0\u1eddng x\u1ea3y ra khi m\u1edbi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n khi d\u00f9ng c\u00f9ng b\u1eefa \u0103n ho\u1eb7c t\u0103ng li\u1ec1u d\u1ea7n.<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: V\u1ecb gi\u00e1c thay \u0111\u1ed5i th\u1ea5t th\u01b0\u1eddng<\/p>\n<p>R\u1ea5t hi\u1ebfm:<\/p>\n<ul>\n<li>Nhi\u1ec5m acid lactic.<\/li>\n<li>Gi\u1ea3m h\u1ea5p thu vitamin B12 d\u1eabn \u0111\u1ebfn gi\u1ea3m n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh khi s\u1eed d\u1ee5ng l\u00e2u d\u00e0i.<\/li>\n<li>B\u1ea5t th\u01b0\u1eddng x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan, vi\u00eam gan, c\u1ea7n ng\u1eebng thu\u1ed1c.<\/li>\n<li>Ph\u1ea3n \u1ee9ng da: m\u1ea9n \u0111\u1ecf, m\u00e0y \u0111ay, ng\u1ee9a.<\/li>\n<li>\u1ede tr\u1ebb em t\u1eeb 10\u201316 tu\u1ed5i, c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n ghi nh\u1eadn t\u01b0\u01a1ng t\u1ef1 ng\u01b0\u1eddi l\u1edbn v\u1ec1 m\u1ee9c \u0111\u1ed9 v\u00e0 t\u1ea7n su\u1ea5t.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p><em><strong>Kh\u00f4ng khuy\u1ebfn c\u00e1o ph\u1ed1i h\u1ee3p<\/strong><\/em><\/p>\n<p>R\u01b0\u1ee3u: T\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic, \u0111\u1eb7c bi\u1ec7t khi b\u1ec7nh nh\u00e2n suy gan, nh\u1ecbn \u0103n ho\u1eb7c suy dinh d\u01b0\u1ee1ng.<\/p>\n<p>Ch\u1ea5t c\u1ea3n quang ch\u1ee9a iod: C\u1ea7n ng\u1eebng metformin tr\u01b0\u1edbc ho\u1eb7c ngay khi ti\u1ebfn h\u00e0nh ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh, ch\u1ec9 d\u00f9ng l\u1ea1i sau \u00edt nh\u1ea5t 48 gi\u1edd khi \u0111\u00e3 \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn \u1ed5n \u0111\u1ecbnh.<\/p>\n<p><em><strong>C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p<\/strong><\/em><\/p>\n<p>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng th\u1eadn nh\u01b0 NSAID, thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 angiotensin II, thu\u1ed1c l\u1ee3i ti\u1ec3u (\u0111\u1eb7c bi\u1ec7t l\u1ee3i ti\u1ec3u quai).<\/p>\n<p>Thu\u1ed1c c\u00f3 xu h\u01b0\u1edbng t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft nh\u01b0 glucocorticoid (to\u00e0n th\u00e2n ho\u1eb7c t\u1ea1i ch\u1ed7), c\u00e1c ch\u1ea5t k\u00edch th\u00edch giao c\u1ea3m.<\/p>\n<p><em><strong>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn v\u1eadn chuy\u1ec3n cation h\u1eefu c\u01a1 (OCT)<\/strong><\/em><\/p>\n<p>\u1ee8c ch\u1ebf OCT1 (nh\u01b0 verapamil) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a metformin.<\/p>\n<p>C\u1ea3m \u1ee9ng OCT1 (nh\u01b0 rifampicin) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/p>\n<p>\u1ee8c ch\u1ebf OCT2 (nh\u01b0 cimetidin, dolutegravir, trimethoprim, ranolazine, v.v.) l\u00e0m gi\u1ea3m th\u1ea3i tr\u1eeb qua th\u1eadn, t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u.<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf c\u1ea3 OCT1 v\u00e0 OCT2 (nh\u01b0 crizotinib, olaparib) c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i hi\u1ec7u l\u1ef1c v\u00e0 th\u1ea3i tr\u1eeb metformin.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Th\u1eddi k\u1ef3 mang thai: Kh\u00f4ng khuy\u1ebfn kh\u00edch d\u00f9ng metformin cho ph\u1ee5 n\u1eef \u0111ang mang thai ho\u1eb7c c\u00f3 k\u1ebf ho\u1ea1ch mang thai. Thay v\u00e0o \u0111\u00f3, insulin \u0111\u01b0\u1ee3c \u01b0u ti\u00ean nh\u1eb1m gi\u1eef \u0111\u01b0\u1eddng huy\u1ebft g\u1ea7n m\u1ee9c b\u00ecnh th\u01b0\u1eddng nh\u1ea5t, gi\u1ea3m nguy c\u01a1 d\u1ecb t\u1eadt thai.<\/p>\n<p>Th\u1eddi k\u1ef3 cho con b\u00fa: Thu\u1ed1c c\u00f3 th\u1ec3 qua s\u1eefa m\u1eb9, tuy kh\u00f4ng ghi nh\u1eadn t\u00e1c h\u1ea1i tr\u00ean tr\u1ebb b\u00fa m\u1eb9 nh\u01b0ng do d\u1eef li\u1ec7u c\u00f2n h\u1ea1n ch\u1ebf, n\u00ean c\u00e2n nh\u1eafc ng\u1eebng cho b\u00fa ho\u1eb7c ng\u1eebng thu\u1ed1c t\u00f9y tr\u01b0\u1eddng h\u1ee3p.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p><span style=\"font-size: 14.4px;\">Khi d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u metformin, thu\u1ed1c kh\u00f4ng g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, do \u0111\u00f3 h\u1ea7u nh\u01b0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Tuy nhi\u00ean, c\u1ea7n th\u1eadn tr\u1ecdng khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c (nh\u01b0 sulfonylurea, insulin, meglitinid) v\u00ec c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/span><\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>D\u00f9ng qu\u00e1 li\u1ec1u metformin (ghi nh\u1eadn \u0111\u1ebfn 85 g) hi\u1ebfm khi g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft nh\u01b0ng c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec5m acid lactic, m\u1ed9t t\u00ecnh tr\u1ea1ng nguy hi\u1ec3m c\u1ea7n nh\u1eadp vi\u1ec7n ngay. Bi\u1ec7n ph\u00e1p hi\u1ec7u qu\u1ea3 nh\u1ea5t \u0111\u1ec3 lo\u1ea1i b\u1ecf lactat v\u00e0 metformin l\u00e0 l\u1ecdc m\u00e1u.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Glucophage 500mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Glucophage 500mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Glucophage 500mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Glucophage 500mg nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/glucophage-xr-500mg\/\">Glucophage XR 500mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Metformin hydrochloride v\u1edbi h\u00e0m l\u01b0\u1ee3ng 500mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Merck Sante s.a.s, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00edp 2<\/p>\n<p><span style=\"font-size: 14.4px;\"><a href=\"https:\/\/vnras.com\/drug\/metformin-stella-500mg\/\">Metformin Stella 500mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Metformin hydrochloride v\u1edbi h\u00e0m l\u01b0\u1ee3ng 500mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Li\u00ean Doanh Stellapharm \u2013 Chi nh\u00e1nh 1, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00edp 2<\/span><\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Glucophage 500mg \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/To-huong-dan-su-dung-Glucophage-500mg-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 8 n\u0103m 2025<\/li>\n<li>Lv Z, Guo Y (2020). Metformin and Its Benefits for Various Diseases. Front Endocrinol (Lausanne). Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 8 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7212476\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7212476\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Glucophage 500mg l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2 ch\u1ee9a Metformin hydroclorid, d\u00f9ng \u0111\u01a1n tr\u1ecb ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, k\u1ec3 c\u1ea3 insulin.<\/p>\n","protected":false},"author":1,"featured_media":135095,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-135084","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/135084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=135084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/135095"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=135084"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=135084"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=135084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}