{"id":134783,"date":"2025-08-25T01:42:35","date_gmt":"2025-08-24T18:42:35","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=134783"},"modified":"2025-08-25T01:51:15","modified_gmt":"2025-08-24T18:51:15","slug":"glotadol-f","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/glotadol-f\/","title":{"rendered":"Glotadol F"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Glotadol F \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH Abbott Healthcare Vi\u1ec7t Nam c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-13410-10<\/strong><\/p>\n<h2>Glotadol F l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Glotadol F<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<p>Paracetamol: 500 mg<\/p>\n<p>Phenylephrin hydroclorid: 7,5 mg<\/p>\n<p>Loratadin: 5 mg<\/p>\n<p>Dextromethorphan hydrobromid: 15 mg<\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Cellulose vi tinh th\u1ec3 102, tinh b\u1ed9t ti\u1ec1n gelatin h\u00f3a, povidon K30, natri starch glycolat, silica dioxyd keo, talc, magnesi stearat, opadry green.<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-13410-10<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Glotadol F<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Paracetamol: Gi\u00fap h\u1ea1 s\u1ed1t v\u00e0 gi\u1ea3m \u0111au th\u00f4ng qua vi\u1ec7c l\u00e0m t\u0103ng ng\u01b0\u1ee1ng ch\u1ecbu \u0111au v\u00e0 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn trung t\u00e2m \u0111i\u1ec1u nhi\u1ec7t t\u1ea1i v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i.<\/p>\n<p>Phenylephrin hydroclorid: C\u00f3 t\u00e1c d\u1ee5ng co m\u1ea1ch, l\u00e0m gi\u1ea3m s\u01b0ng n\u1ec1 v\u00e0 ngh\u1eb9t m\u0169i, gi\u00fap c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng kh\u00f3 th\u1edf do t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean.<\/p>\n<p>Loratadin: L\u00e0 thu\u1ed1c kh\u00e1ng histamin th\u1ebf h\u1ec7 2, \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc tr\u00ean th\u1ee5 th\u1ec3 H1 ngo\u1ea1i bi\u00ean, c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i, gi\u00fap gi\u1ea3m h\u1eaft h\u01a1i, ch\u1ea3y m\u0169i v\u00e0 ng\u1ee9a m\u0169i h\u1ecdng.<\/p>\n<p>Dextromethorphan: T\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean trung t\u00e2m ho \u1edf h\u00e0nh n\u00e3o, gi\u00fap \u1ee9c ch\u1ebf ph\u1ea3n x\u1ea1 ho khan, kh\u00f4ng c\u00f3 \u0111\u1eddm.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Paracetamol: H\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau 30\u201360 ph\u00fat. Kho\u1ea3ng 25% thu\u1ed1c g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 1,25\u20133 gi\u1edd, ch\u1ee7 y\u1ebfu th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng \u0111\u00e3 li\u00ean h\u1ee3p. M\u1ed9t ph\u1ea7n nh\u1ecf chuy\u1ec3n h\u00f3a th\u00e0nh NAPQI, ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c trung h\u00f2a nh\u1edd glutathion.<\/p>\n<p>Phenylephrin hydroclorid: H\u1ea5p thu kh\u00f4ng \u1ed5n \u0111\u1ecbnh do b\u1ecb chuy\u1ec3n h\u00f3a qua ru\u1ed9t v\u00e0 gan nh\u1edd enzym MAO, sinh kh\u1ea3 d\u1ee5ng th\u1ea5p (5\u201338%). T\u00e1c d\u1ee5ng th\u00f4ng m\u0169i kh\u1edfi ph\u00e1t sau 15\u201320 ph\u00fat, k\u00e9o d\u00e0i 2\u20134 gi\u1edd. Th\u1ea3i tr\u1eeb qua th\u1eadn, ch\u1ee7 y\u1ebfu \u1edf d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 2\u20133 gi\u1edd.<\/p>\n<p>Loratadin: H\u1ea5p thu nhanh, ph\u00e1t huy t\u00e1c d\u1ee5ng sau 1\u20134 gi\u1edd v\u00e0 duy tr\u00ec tr\u00ean 24 gi\u1edd. Chuy\u1ec3n h\u00f3a b\u01b0\u1edbc m\u1ed9t \u1edf gan th\u00e0nh desloratadin \u2013 ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh. 98% thu\u1ed1c g\u1eafn protein huy\u1ebft t\u01b0\u01a1ng. Th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a. Th\u1eddi gian b\u00e1n th\u1ea3i loratadin trung b\u00ecnh 8,4 gi\u1edd v\u00e0 c\u1ee7a desloratadin kho\u1ea3ng 28 gi\u1edd.<\/p>\n<p>Dextromethorphan: Sau khi u\u1ed1ng h\u1ea5p thu nhanh, t\u00e1c d\u1ee5ng xu\u1ea5t hi\u1ec7n sau 15 \u0111\u1ebfn 30 ph\u00fat, k\u00e9o d\u00e0i 6\u20138 gi\u1edd. Thu\u1ed1c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu t\u1ea1i gan, th\u1ea3i tr\u1eeb qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t g\u1ed1c v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a nh\u01b0 dextrorphan.<\/p>\n<h2>Thu\u1ed1c Glotadol F \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 gi\u1ea3m nhanh c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ea3m l\u1ea1nh, c\u1ea3m c\u00fam th\u00f4ng th\u01b0\u1eddng nh\u01b0: ngh\u1eb9t m\u0169i, h\u1eaft h\u01a1i, s\u1ed5 m\u0169i, vi\u00eam m\u0169i d\u1ecb \u1ee9ng, n\u1ed5i m\u1ec1 \u0111ay, ng\u1ee9a m\u0169i h\u1ecdng, ho khan, s\u1ed1t, \u0111au \u0111\u1ea7u, nh\u1ee9c m\u1ecfi c\u01a1 th\u1ec3 v\u00e0 \u0111au \u0111\u1ea7u k\u00e8m vi\u00eam xoang.<\/p>\n<figure id=\"attachment_134784\" aria-describedby=\"caption-attachment-134784\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-134784\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1.jpg\" alt=\"Glotadol F\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1-533x400.jpg 533w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1-1067x800.jpg 1067w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1-768x576.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/1-1-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-134784\" class=\"wp-caption-text\">Thu\u1ed1c Glotadol F gi\u00fap h\u1ea1 s\u1ed1t, gi\u1ea3m \u0111au nh\u1ee9c, l\u00e0m th\u00f4ng m\u0169i, kh\u00e1ng d\u1ecb \u1ee9ng v\u00e0 gi\u1ea3m ho khan, nh\u1edd \u0111\u00f3 c\u1ea3i thi\u1ec7n nhanh ch\u00f3ng t\u00ecnh tr\u1ea1ng kh\u00f3 ch\u1ecbu do b\u1ec7nh g\u00e2y ra.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb tr\u00ean 12 tu\u1ed5i: 1 vi\u00ean\/l\u1ea7n, ng\u00e0y 2 l\u1ea7n.<\/p>\n<p>Tr\u1ebb em t\u1eeb 6 \u2013 12 tu\u1ed5i: D\u00f9ng b\u1eb1ng 1\/2 li\u1ec1u c\u1ee7a ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>Tr\u1ebb em d\u01b0\u1edbi 6 tu\u1ed5i: Ch\u1ec9 d\u00f9ng khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>U\u1ed1ng <strong>vi\u00ean n\u00e9n \u200b\u200bGlotadol F<\/strong> trong b\u1eefa \u0103n ho\u1eb7c sau b\u1eefa \u0103n, d\u00f9ng v\u1edbi n\u01b0\u1edbc l\u1ecdc.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Glotadol F trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi Paracetamol, Phenylephrin, Loratadin, Dextromethorphan v\u00e0 b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Glotadol F<\/p>\n<p>Ng\u01b0\u1eddi suy gan, suy th\u1eadn n\u1eb7ng ho\u1eb7c thi\u1ebfu men G6PD.<\/p>\n<p>B\u1ec7nh nh\u00e2n nhi\u1ec1u l\u1ea7n thi\u1ebfu m\u00e1u.<\/p>\n<p>Ng\u01b0\u1eddi m\u1eafc b\u1ec7nh tim m\u1ea1ch n\u1eb7ng, c\u01b0\u1eddng gi\u00e1p, t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng, nhanh th\u1ea5t, x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, ph\u00ecnh \u0111\u1ed9ng m\u1ea1ch ch\u1ee7.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf monoamin oxydase ho\u1eb7c m\u1edbi d\u1eebng thu\u1ed1c n\u00e0y ch\u01b0a qu\u00e1 14 ng\u00e0y.<\/p>\n<p>Tr\u1ebb d\u01b0\u1edbi 2 tu\u1ed5i.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Paracetamol: Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi u\u1ed1ng r\u01b0\u1ee3u, c\u00f3 b\u1ec7nh gan ho\u1eb7c th\u1eadn.<\/p>\n<p>Phenylephrin: C\u1ea9n tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p, tim m\u1ea1ch, glaucoma g\u00f3c h\u1eb9p, b\u1ec7nh tuy\u1ebfn gi\u00e1p, ti\u1ec3u \u0111\u01b0\u1eddng, ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n<p>Loratadin: Ch\u00fa \u00fd \u1edf b\u1ec7nh nh\u00e2n suy gan, suy th\u1eadn. N\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u b\u1ea5t th\u01b0\u1eddng tr\u00ean da nh\u01b0 ph\u00e1t ban, b\u1ecdng n\u01b0\u1edbc, th\u00e2m t\u00edm c\u1ea7n ng\u1eebng thu\u1ed1c v\u00e0 b\u00e1o cho b\u00e1c s\u0129.<\/p>\n<p>Dextromethorphan: Tr\u00e1nh u\u1ed1ng r\u01b0\u1ee3u trong qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c. L\u1ea1m d\u1ee5ng c\u00f3 th\u1ec3 x\u1ea3y ra khi d\u00f9ng k\u00e9o d\u00e0i ho\u1eb7c li\u1ec1u cao.<\/p>\n<p>Ngo\u00e0i ra, b\u00e1c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o ng\u01b0\u1eddi b\u1ec7nh v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng da n\u1eb7ng hi\u1ebfm g\u1eb7p nh\u01b0 h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c hay h\u1ed9i ch\u1ee9ng Lyell.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng Glotadol F, c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn t\u1eebng th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t:<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Paracetamol:<\/strong><\/span><\/p>\n<p>\u00cdt g\u1eb7p: n\u1ed5i m\u1ea9n da, bu\u1ed3n n\u00f4n, n\u00f4n, r\u1ed1i lo\u1ea1n m\u00e1u (gi\u1ea3m b\u1ea1ch c\u1ea7u, thi\u1ebfu m\u00e1u, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u), t\u1ed5n th\u01b0\u01a1ng th\u1eadn khi d\u00f9ng li\u1ec1u cao k\u00e9o d\u00e0i.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn, h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson, Lyell, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, m\u1ee5n m\u1ee7 c\u1ea5p t\u00ednh to\u00e0n th\u00e2n.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Phenylephrin:<\/strong><\/span><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: b\u1ed3n ch\u1ed3n, lo l\u1eafng, kh\u00f3 ng\u1ee7, ch\u00f3ng m\u1eb7t, run, \u0111au t\u1ee9c ng\u1ef1c, tim \u0111\u1eadp nhanh, t\u0103ng huy\u1ebft \u00e1p, da t\u00e1i nh\u1ee3t, c\u1ea3m gi\u00e1c l\u1ea1nh, n\u1ed5i da g\u00e0.<\/p>\n<p>\u00cdt g\u1eb7p: r\u1ed1i lo\u1ea1n nh\u1ecbp tim, nh\u1ecbp ch\u1eadm, co m\u1ea1ch g\u00e2y gi\u1ea3m t\u01b0\u1edbi m\u00e1u n\u1ed9i t\u1ea1ng, kh\u00f3 th\u1edf, \u1ea3o gi\u00e1c, k\u00edch \u0111\u1ed9ng, hoang t\u01b0\u1edfng, ho\u1ea1i t\u1eed ho\u1eb7c bong tr\u00f3c da khi ti\u00eam tho\u00e1t m\u1ea1ch, t\u1ed5n th\u01b0\u01a1ng m\u1eaft.<\/p>\n<p>Hi\u1ebfm: vi\u00eam c\u01a1 tim, xu\u1ea5t huy\u1ebft quanh m\u00e0ng tim.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Loratadin<\/strong><\/span>:<\/p>\n<p>\u00cdt g\u1eb7p: ch\u00f3ng m\u1eb7t, kh\u00f4 m\u0169i, h\u1eaft h\u01a1i, vi\u00eam k\u1ebft m\u1ea1c.<\/p>\n<p>Hi\u1ebfm: tr\u1ea7m c\u1ea3m, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh, bu\u1ed3n n\u00f4n, r\u1ed1i lo\u1ea1n kinh nguy\u1ec7t, t\u0103ng men gan, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn (ngo\u1ea1i ban, m\u00e0y \u0111ay, s\u1ed1c ph\u1ea3n v\u1ec7).<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Dextromethorphan:<\/strong><\/span><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: bu\u1ed3n n\u00f4n, \u0111\u1ecf m\u1eb7t, m\u1ec7t m\u1ecfi, ch\u00f3ng m\u1eb7t, tim \u0111\u1eadp nhanh.<\/p>\n<p>\u00cdt g\u1eb7p: n\u1ed5i m\u1ec1 \u0111ay.<\/p>\n<p>Hi\u1ebfm: bu\u1ed3n ng\u1ee7, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u1eb9.<\/p>\n<p>L\u01b0u \u00fd x\u1eed tr\u00ed:<\/p>\n<ul>\n<li>V\u1edbi phenylephrin g\u00e2y nh\u1ecbp tim ch\u1eadm \u2192 c\u00f3 th\u1ec3 d\u00f9ng atropin; n\u1ebfu g\u00e2y t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng \u2192 d\u00f9ng thu\u1ed1c ch\u1eb9n alpha (nh\u01b0 phentolamin).<\/li>\n<li>V\u1edbi dextromethorphan g\u00e2y suy h\u00f4 h\u1ea5p, \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng \u2192 d\u00f9ng naloxon t\u0129nh m\u1ea1ch (2\u201310 mg) \u0111\u1ec3 gi\u1ea3i \u0111\u1ed9c.<\/li>\n<li>Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n ng\u01b0ng thu\u1ed1c v\u00e0 li\u00ean h\u1ec7 b\u00e1c s\u0129 n\u1ebfu c\u00f3 bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng nh\u01b0 ph\u00e1t ban, ph\u00f9, h\u1ed3i h\u1ed9p, m\u1ea5t ng\u1ee7, ch\u00f3ng m\u1eb7t ho\u1eb7c khi tri\u1ec7u ch\u1ee9ng kh\u00f4ng c\u1ea3i thi\u1ec7n sau 7 ng\u00e0y.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Paracetamol: R\u01b0\u1ee3u l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a paracetamol c\u00f3 trong vi\u00ean n\u00e9n Glotadol F tr\u00ean gan. D\u00f9ng li\u1ec1u cao k\u00e9o d\u00e0i c\u00f9ng thu\u1ed1c ch\u1ed1ng co gi\u1eadt (phenytoin, barbiturat, carbamazepin), thu\u1ed1c c\u1ea3m \u1ee9ng enzym gan ho\u1eb7c isoniazid \u2192 t\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng gan. T\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng (coumarin, indandion). Metoclopramid, domperidon c\u00f3 th\u1ec3 l\u00e0m t\u0103ng h\u1ea5p thu paracetamol c\u00f3 trong vi\u00ean n\u00e9n Glotadol F, c\u00f2n colestyramin l\u00e0m gi\u1ea3m h\u1ea5p thu ho\u1ea1t ch\u1ea5t n\u00e0y<\/p>\n<p>Phenylephrin: C\u00f3 nguy c\u01a1 g\u00e2y lo\u1ea1n nh\u1ecbp, rung th\u1ea5t khi k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c g\u00e2y m\u00ea \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p (cyclopropan, halothan). Chuy\u1ec3n h\u00f3a b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi thu\u1ed1c \u1ee9c ch\u1ebf MAO. M\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn khi ph\u1ed1i h\u1ee3p v\u1edbi debrisoquin.<\/p>\n<p>Loratadin: B\u1ecb chuy\u1ec3n h\u00f3a b\u1edfi CYP450. D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf enzym n\u00e0y (cimetidin, erythromycin, ketoconazol, quinidin, fluconazol, fluoxetin) \u2192 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 loratadin trong m\u00e1u.<\/p>\n<p>Dextromethorphan: Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng ho\u1eb7c trong v\u00f2ng 14 ng\u00e0y sau thu\u1ed1c \u1ee9c ch\u1ebf MAO do nguy c\u01a1 ph\u1ea3n \u1ee9ng n\u1eb7ng. D\u01b0\u1ee3c ch\u1ea5t b\u1ecb chuy\u1ec3n h\u00f3a qua CYP2D6, n\u00ean c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi amiodaron, fluoxetin, haloperidol, paroxetin, propafenon, quinidin, thioridazin. Khi ph\u1ed1i h\u1ee3p v\u1edbi r\u01b0\u1ee3u, thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, thu\u1ed1c an th\u1ea7n, kh\u00e1ng histamin \u2192 t\u0103ng nguy c\u01a1 \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: Hi\u1ec7n ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u kh\u1eb3ng \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 an to\u00e0n \u0111\u1ed1i v\u1edbi thai nhi. Do \u0111\u00f3, ch\u1ec9 n\u00ean d\u00f9ng Glotadol F khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh t\u1eeb b\u00e1c s\u0129.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Paracetamol th\u01b0\u1eddng an to\u00e0n, kh\u00f4ng \u1ea3nh h\u01b0\u1edfng r\u00f5 r\u1ec7t \u0111\u1ebfn tr\u1ebb b\u00fa m\u1eb9. Tuy nhi\u00ean, phenylephrin v\u00e0 loratadin c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u00e0 g\u00e2y t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i cho tr\u1ebb. V\u00ec v\u1eady, c\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb cho m\u1eb9 v\u00e0 nguy c\u01a1 \u0111\u1ed1i v\u1edbi tr\u1ebb \u0111\u1ec3 quy\u1ebft \u0111\u1ecbnh ng\u01b0ng thu\u1ed1c ho\u1eb7c t\u1ea1m ng\u1eebng cho b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Dextromethorphan \u0111\u00f4i khi g\u00e2y ra c\u1ea3m gi\u00e1c cho\u00e1ng v\u00e1ng v\u00e0 h\u01a1i bu\u1ed3n ng\u1ee7. Ng\u01b0\u1eddi \u0111ang l\u00e1i xe ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p><em><strong>Paracetamol<\/strong><\/em><\/p>\n<p>Bi\u1ec3u hi\u1ec7n: trong v\u00e0i gi\u1edd \u0111\u1ea7u c\u00f3 bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, da t\u00e1i xanh. Qu\u00e1 li\u1ec1u l\u1edbn (\u226510 g \u1edf ng\u01b0\u1eddi l\u1edbn ho\u1eb7c 150 mg\/kg \u1edf tr\u1ebb nh\u1ecf) c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ho\u1ea1i t\u1eed gan, t\u0103ng men gan, toan chuy\u1ec3n h\u00f3a, h\u00f4n m\u00ea, th\u1eadm ch\u00ed t\u1eed vong.<\/p>\n<p>X\u1eed tr\u00ed: r\u1eeda d\u1ea1 d\u00e0y, than ho\u1ea1t, d\u00f9ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u N-acetylcystein c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t (t\u1ed1t nh\u1ea5t trong 10 gi\u1edd \u0111\u1ea7u).<\/p>\n<p><em><strong>Phenylephrin<\/strong><\/em><\/p>\n<p>Bi\u1ec3u hi\u1ec7n: nh\u1ecbp ch\u1eadm, t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng, v\u00e3 m\u1ed3 h\u00f4i, ch\u00f3ng m\u1eb7t, h\u00f4n m\u00ea.<\/p>\n<p>X\u1eed tr\u00ed: \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3, c\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c gi\u00e3n m\u1ea1ch nhanh nh\u01b0 glyceryl trinitrat khi t\u0103ng huy\u1ebft \u00e1p n\u1eb7ng.<\/p>\n<p><em><strong>Loratadin<\/strong><\/em><\/p>\n<p>Bi\u1ec3u hi\u1ec7n: bu\u1ed3n ng\u1ee7, tim \u0111\u1eadp nhanh, nh\u1ee9c \u0111\u1ea7u.<\/p>\n<p>X\u1eed tr\u00ed: \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng, c\u00f3 th\u1ec3 g\u00e2y n\u00f4n ho\u1eb7c r\u1eeda d\u1ea1 d\u00e0y khi ng\u1ed9 \u0111\u1ed9c c\u1ea5p.<\/p>\n<p><em><strong>Dextromethorphan<\/strong><\/em><\/p>\n<p>Bi\u1ec3u hi\u1ec7n: bu\u1ed3n n\u00f4n, n\u00f4n, \u1ea3o gi\u00e1c, nh\u00ecn m\u1edd, bu\u1ed3n ng\u1ee7, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, suy h\u00f4 h\u1ea5p, co gi\u1eadt.<\/p>\n<p>X\u1eed tr\u00ed: \u0111\u01b0a b\u1ec7nh nh\u00e2n \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t, h\u1ed7 tr\u1ee3 h\u00f4 h\u1ea5p v\u00e0 tu\u1ea7n ho\u00e0n. C\u00f3 th\u1ec3 d\u00f9ng naloxon t\u0129nh m\u1ea1ch \u0111\u1ec3 gi\u1ea3i \u0111\u1ed9c.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Glotadol F \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Glotadol F trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Glotadol F khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Glotadol F gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Glotadol F hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Glotadol F c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Glotadol F t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Glotadol F nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/tanadotuxsin\/\">TanaDotuxsin<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol, Phenylephrin, Dextromethorphan, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH SX-TM d\u01b0\u1ee3c ph\u1ea9m Th\u00e0nh Nam, \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/vintrosin-new\/\">Vintrosin New<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol, Phenylephrin, Dextromethorphan, Guaifenesin, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m V\u0129nh Ph\u00fac, \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Glotadol F \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/To-huong-dan-su-dung-Glotadol-F-vnras.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 25 th\u00e1ng 8 n\u0103m 2025<\/li>\n<li>de Oliveira GG, Feitosa A, Loureiro K, Fernandes AR, Souto EB, Severino P (2017). Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures. Saudi Pharm J. Truy c\u1eadp ng\u00e0y 25 th\u00e1ng 8 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5310159\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5310159\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Glotadol F l\u00e0 h\u1ed7n 4 ho\u1ea1t ch\u1ea5t gi\u00fap h\u1ea1 s\u1ed1t, gi\u1ea3m \u0111au nh\u1ee9c, l\u00e0m th\u00f4ng m\u0169i, kh\u00e1ng d\u1ecb \u1ee9ng v\u00e0 gi\u1ea3m ho khan, nh\u1edd \u0111\u00f3 c\u1ea3i thi\u1ec7n nhanh ch\u00f3ng t\u00ecnh tr\u1ea1ng kh\u00f3 ch\u1ecbu do b\u1ec7nh g\u00e2y ra.<\/p>\n","protected":false},"author":1,"featured_media":134785,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-134783","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/134783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=134783"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/134785"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=134783"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=134783"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=134783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}