{"id":133944,"date":"2025-08-21T03:54:49","date_gmt":"2025-08-20T20:54:49","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=133944"},"modified":"2025-08-21T03:56:36","modified_gmt":"2025-08-20T20:56:36","slug":"pabemin-325","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/pabemin-325\/","title":{"rendered":"Pabemin 325"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Pabemin 325 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m C\u1eedu Long c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893100067900 (S\u0110K c\u0169: VD-27840-17)<\/strong><\/p>\n<h2>Pabemin 325 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>g\u00f3i Pabemin 325<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Paracetamol (Acetaminophen, N-acetyl-p-aminophenol)&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.325mg<\/li>\n<li>Clorpheniramin maleat&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.2mg<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Thu\u1ed1c c\u1ed1m<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893100067900 (S\u0110K c\u0169: VD-27840-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 30 G\u00f3i<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Pabemin 325<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Paracetamol: l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a phenacetin, c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t v\u00e0 gi\u1ea3m \u0111au. Thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i, l\u00e0m gi\u00e3n m\u1ea1ch ngo\u1ea1i bi\u00ean, t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u qua da gi\u00fap t\u1ecfa nhi\u1ec7t. Kh\u00e1c v\u1edbi salicylat, paracetamol kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng hay ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y v\u00ec kh\u00f4ng \u1ee9c ch\u1ebf cyclooxygenase to\u00e0n th\u00e2n, m\u00e0 ch\u1ee7 y\u1ebfu t\u00e1c \u0111\u1ed9ng t\u1ea1i h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u v\u00e0 th\u1eddi gian ch\u1ea3y m\u00e1u.<\/p>\n<p>Clorpheniramin maleat: l\u00e0 thu\u1ed1c kh\u00e1ng histamin H1, c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ea1nh tranh t\u1ea1i th\u1ee5 th\u1ec3 H1 c\u1ee7a t\u1ebf b\u00e0o \u0111\u00edch, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng d\u1ecb \u1ee9ng nh\u01b0 h\u1eaft h\u01a1i, s\u1ed5 m\u0169i, ng\u1ee9a. Thu\u1ed1c c\u00f3 th\u00eam t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft cholin \u1edf m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau gi\u1eefa c\u00e1c c\u00e1 th\u1ec3.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Paracetamol: h\u1ea5p thu nhanh v\u00e0 g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng u\u1ed1ng, ph\u00e2n b\u1ed1 \u0111\u1ed3ng \u0111\u1ec1u trong h\u1ea7u h\u1ebft m\u00f4 c\u01a1 th\u1ec3, kho\u1ea3ng 25% g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Gan l\u00e0 n\u01a1i chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu c\u1ee7a thu\u1ed1c th\u00f4ng qua li\u00ean h\u1ee3p sulfat v\u00e0 glucuronid, s\u1ea3n ph\u1ea9m cu\u1ed1i c\u00f9ng \u0111\u00e0o th\u1ea3i ra ngo\u00e0i qua n\u01b0\u1edbc ti\u1ec3u.. Th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 1 \u2013 3 gi\u1edd. M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua cytochrom P450 th\u00e0nh N-acetyl-p-benzoquinonimin (NAPQI), ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c kh\u1eed ho\u1ea1t t\u00ednh nh\u1edd glutathion. Khi qu\u00e1 li\u1ec1u ho\u1eb7c suy gi\u1ea3m glutathion, NAPQI c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c t\u00ednh gan.<\/p>\n<p>Clorpheniramin maleat: h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng sau 30 \u2013 60 ph\u00fat. Thu\u1ed1c chuy\u1ec3n h\u00f3a m\u1ea1nh \u1edf gan, t\u1ea1o ra c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a nh\u01b0 desmethyl v\u00e0 didesmethyl-clorpheniramin, m\u1ed9t s\u1ed1 c\u00f3 ho\u1ea1t t\u00ednh. B\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c g\u1ed1c ho\u1eb7c ch\u1ea5t chuy\u1ec3n h\u00f3a, ph\u1ee5 thu\u1ed9c v\u00e0o pH v\u00e0 l\u01b0u l\u01b0\u1ee3ng n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh \u1edf ng\u01b0\u1eddi l\u1edbn 12 \u2013 43 gi\u1edd, tr\u1ebb em 5,2 \u2013 23,1 gi\u1edd, k\u00e9o d\u00e0i h\u01a1n \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn m\u1ea1n.<\/p>\n<h2>Thu\u1ed1c Pabemin 325 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>S\u1ed1t nh\u1eb9 \u0111\u1ebfn v\u1eeba.<\/p>\n<p>C\u1ea3m l\u1ea1nh, c\u1ea3m c\u00fam.<\/p>\n<p>Ho, s\u1ed5 m\u0169i, ngh\u1eb9t m\u0169i k\u00e8m s\u1ed1t.<\/p>\n<figure id=\"attachment_133957\" aria-describedby=\"caption-attachment-133957\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-133957\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Pabemin-325.jpg\" alt=\"Pabemin 325\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Pabemin-325.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Pabemin-325-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Pabemin-325-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Pabemin-325-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-133957\" class=\"wp-caption-text\">Thu\u1ed1c Pabemin 325 c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t, gi\u1ea3m \u0111au k\u00e8m theo kh\u00e1ng histamin gi\u00fap c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng d\u1ecb \u1ee9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i: U\u1ed1ng 1 \u2013 2 g\u00f3i Pabemin m\u1ed7i l\u1ea7n.<\/p>\n<p>Tr\u1ebb em t\u1eeb 6 \u2013 12 tu\u1ed5i: U\u1ed1ng 1 g\u00f3i Pabemin\/l\u1ea7n.<\/p>\n<p>Kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c l\u1ea7n u\u1ed1ng: 4 \u2013 6 gi\u1edd, kh\u00f4ng qu\u00e1 5 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Kh\u00f4ng t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c qu\u00e1 5 ng\u00e0y li\u00ean t\u1ee5c n\u1ebfu \u0111au kh\u00f4ng gi\u1ea3m, ho\u1eb7c qu\u00e1 3 ng\u00e0y n\u1ebfu s\u1ed1t tr\u00ean 39,5\u00b0C ho\u1eb7c t\u00e1i ph\u00e1t.<\/p>\n<p>Tr\u1ebb em d\u01b0\u1edbi 6 tu\u1ed5i: ch\u1ec9 d\u00f9ng khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>H\u00f2a tan g\u00f3i <strong>c\u1ed1m u\u1ed1ng Pabemin 325<\/strong> v\u00e0o n\u01b0\u1edbc, khu\u1ea5y \u0111\u1ec1u tr\u01b0\u1edbc khi u\u1ed1ng.<\/p>\n<p>Tu\u00e2n th\u1ee7 \u0111\u00fang li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Pabemin 325 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi paracetamol th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c kh\u00e1c c\u00f3 trong Pabemin 325<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 glaucom g\u00f3c h\u1eb9p, ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t, c\u01a1n hen c\u1ea5p, t\u1eafc c\u1ed5 b\u00e0ng quang, t\u1eafc m\u00f4n v\u1ecb &#8211; t\u00e1 tr\u00e0ng.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf MAO trong v\u00f2ng 14 ng\u00e0y t\u00ednh \u0111\u1ebfn th\u1eddi \u0111i\u1ec3m \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Pabemin 325.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa, tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb sinh non.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh thi\u1ebfu h\u1ee5t men G6PD.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p><em><strong>Paracetamol<\/strong><\/em><\/p>\n<p>C\u00f3 nguy c\u01a1 ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng (h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c, AGEP).<\/p>\n<p>C\u00f3 th\u1ec3 g\u1eb7p ban da, m\u00e0y \u0111ay, ph\u00f9 m\u1ea1ch, s\u1ed1c ph\u1ea3n v\u1ec7, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t khi d\u00f9ng k\u00e9o d\u00e0i ho\u1eb7c li\u1ec1u cao.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi c\u00f3 thi\u1ebfu m\u00e1u t\u1eeb tr\u01b0\u1edbc.<\/p>\n<p>Khi u\u1ed1ng r\u01b0\u1ee3u nhi\u1ec1u, nguy c\u01a1 gan b\u1ecb nhi\u1ec5m \u0111\u1ed9c do thu\u1ed1c s\u1ebd cao h\u01a1n<\/p>\n<p><em><strong>Clorpheniramin<\/strong><\/em><\/p>\n<p>C\u00f3 th\u1ec3 g\u00e2y b\u00ed ti\u1ec3u, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t, t\u1eafc \u0111\u01b0\u1eddng ni\u1ec7u.<\/p>\n<p>L\u00e0m t\u0103ng nguy c\u01a1 bi\u1ebfn ch\u1ee9ng h\u00f4 h\u1ea5p \u1edf b\u1ec7nh nh\u00e2n t\u1eafc ngh\u1ebdn ph\u1ed5i ho\u1eb7c tr\u1ebb nh\u1ecf.<\/p>\n<p>C\u00f3 th\u1ec3 g\u00e2y kh\u00f4 mi\u1ec7ng, s\u00e2u r\u0103ng khi d\u00f9ng l\u00e2u d\u00e0i.<\/p>\n<p>T\u00e1c d\u1ee5ng an th\u1ea7n t\u0103ng khi d\u00f9ng chung v\u1edbi r\u01b0\u1ee3u ho\u1eb7c thu\u1ed1c an th\u1ea7n kh\u00e1c.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i nh\u1ea1y c\u1ea3m h\u01a1n v\u1edbi t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng nh\u01b0 h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (Lyell), m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p t\u00ednh; tuy hi\u1ebfm g\u1eb7p nh\u01b0ng c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng. Khi th\u1ea5y n\u1ed5i ban ho\u1eb7c bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng tr\u00ean da c\u1ea7n ng\u01b0ng thu\u1ed1c v\u00e0 \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf.<\/p>\n<p>M\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng nh\u1eb9 h\u01a1n c\u00f3 th\u1ec3 g\u1eb7p nh\u01b0 m\u00e0y \u0111ay, ph\u00e1t ban k\u00e8m s\u1ed1t, \u0111\u00f4i khi t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c.<\/p>\n<p>C\u00e1c r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc hi\u1ebfm g\u1eb7p: gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u.<\/p>\n<p>T\u00e1c d\u1ee5ng an th\u1ea7n: m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau t\u00f9y c\u01a1 \u0111\u1ecba, t\u1eeb bu\u1ed3n ng\u1ee7 nh\u1eb9 cho t\u1edbi ng\u1ee7 s\u00e2u, ch\u00f3ng m\u1eb7t, kh\u00f4 mi\u1ec7ng; m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u00f3 th\u1ec3 b\u1ecb k\u00edch th\u00edch ngh\u1ecbch th\u01b0\u1eddng.<\/p>\n<p>ADR th\u01b0\u1eddng g\u1eb7p (\u22651\/100): bu\u1ed3n ng\u1ee7, kh\u00f4 mi\u1ec7ng.<\/p>\n<p>ADR \u00edt g\u1eb7p (\u22651\/1000 \u0111\u1ebfn &lt;1\/100): bu\u1ed3n n\u00f4n, n\u00f4n; r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc (gi\u1ea3m b\u1ea1ch c\u1ea7u, thi\u1ebfu m\u00e1u); \u1ea3nh h\u01b0\u1edfng d\u1ea1 d\u00e0y\u2013ru\u1ed9t; \u0111\u1ed9c t\u00ednh th\u1eadn khi l\u1ea1m d\u1ee5ng k\u00e9o d\u00e0i.<\/p>\n<p>ADR hi\u1ebfm g\u1eb7p (&lt;1\/2000): ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn, ch\u00f3ng m\u1eb7t.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p><em><strong>Paracetamol<\/strong><\/em><\/p>\n<p>S\u1eed d\u1ee5ng d\u00e0i ng\u00e0y li\u1ec1u cao c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u1eb9 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a warfarin, d\u1eabn ch\u1ea5t indandion.<\/p>\n<p>U\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u v\u00e0 k\u00e9o d\u00e0i l\u00e0m t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh tr\u00ean gan.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh (phenytoin, barbiturat, carbamazepin) ho\u1eb7c rifampicin c\u1ea3m \u1ee9ng enzym gan, l\u00e0m t\u0103ng t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u1ed9c, nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng gan cao h\u01a1n.<\/p>\n<p>D\u00f9ng chung v\u1edbi isoniazid c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ed9c t\u00ednh gan.<\/p>\n<p>L\u00e0m k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a chloramphenicol, t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh.<\/p>\n<p>Metoclopramid, domperidon l\u00e0m t\u0103ng t\u1ed1c \u0111\u1ed9 h\u1ea5p thu paracetamol; ng\u01b0\u1ee3c l\u1ea1i, cholestyramin l\u00e0m gi\u1ea3m h\u1ea5p thu n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p><em><strong>Clorpheniramin<\/strong><\/em><\/p>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf MAO l\u00e0m t\u0103ng v\u00e0 k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft cholin.<\/p>\n<p>D\u00f9ng chung r\u01b0\u1ee3u ho\u1eb7c thu\u1ed1c an th\u1ea7n kh\u00e1c c\u00f3 th\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n<p>C\u00f3 th\u1ec3 \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a phenytoin, g\u00e2y ng\u1ed9 \u0111\u1ed9c phenytoin.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai: ch\u1ec9 s\u1eed d\u1ee5ng khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft; kh\u00f4ng khuy\u1ebfn c\u00e1o trong 3 th\u00e1ng cu\u1ed1i thai k\u1ef3 do nguy c\u01a1 g\u00e2y co gi\u1eadt \u1edf tr\u1ebb s\u01a1 sinh.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: ho\u1ea1t ch\u1ea5t c\u00f3 th\u1ec3 ti\u1ebft qua s\u1eefa m\u1eb9, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb v\u00e0 l\u00e0m gi\u1ea3m ti\u1ebft s\u1eefa \u2192 c\u1ea7n c\u00e2n nh\u1eafc ng\u1eebng cho b\u00fa ho\u1eb7c thay th\u1ebf thu\u1ed1c kh\u00e1c an to\u00e0n h\u01a1n.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd, gi\u1ea3m t\u1eadp trung.<\/p>\n<p>Ng\u01b0\u1eddi \u0111ang \u0111i\u1ec1u khi\u1ec3n xe, m\u00e1y m\u00f3c ho\u1eb7c l\u00e0m vi\u1ec7c tr\u00ean cao, c\u00f4ng vi\u1ec7c \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ec3 h\u1ea1n ch\u1ebf nguy c\u01a1 tai n\u1ea1n.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p><span style=\"text-decoration: underline;\"><strong>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u<\/strong><\/span><\/p>\n<p><em><strong>Paracetamol<\/strong><\/em><\/p>\n<p>U\u1ed1ng \u226510 g \u1edf ng\u01b0\u1eddi l\u1edbn ho\u1eb7c \u22655 g \u1edf ng\u01b0\u1eddi c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 (u\u1ed1ng r\u01b0\u1ee3u nhi\u1ec1u, suy dinh d\u01b0\u1ee1ng, d\u00f9ng thu\u1ed1c c\u1ea3m \u1ee9ng enzym gan nh\u01b0 phenytoin, carbamazepin, rifampicin\u2026) c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng gan n\u1eb7ng.<\/p>\n<p>Bi\u1ec3u hi\u1ec7n s\u1edbm (trong 24h): bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00e1n \u0103n, \u0111au b\u1ee5ng, da xanh xao.<\/p>\n<p>Sau 12\u201348h: t\u1ed5n th\u01b0\u01a1ng gan r\u00f5 r\u1ec7t, r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng huy\u1ebft, toan chuy\u1ec3n h\u00f3a. Tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n th\u00e0nh suy gan, h\u00f4n m\u00ea gan, xu\u1ea5t huy\u1ebft, ph\u00f9 n\u00e3o v\u00e0 t\u1eed vong.<\/p>\n<p>Ngo\u00e0i ra c\u00f3 th\u1ec3 g\u1eb7p suy th\u1eadn c\u1ea5p (ho\u1ea1i t\u1eed \u1ed1ng th\u1eadn), ti\u1ec3u m\u00e1u, protein ni\u1ec7u, lo\u1ea1n nh\u1ecbp tim, vi\u00eam t\u1ee5y.<\/p>\n<p><em><strong>Clorpheniramin<\/strong><\/em><\/p>\n<p>Qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 g\u00e2y k\u00edch th\u00edch ngh\u1ecbch th\u01b0\u1eddng h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, \u1ea3o gi\u00e1c, co gi\u1eadt, h\u00f4n m\u00ea, r\u1ed1i lo\u1ea1n nh\u1ecbp tim, tr\u1ee5y tim m\u1ea1ch, ph\u1ea3n \u1ee9ng lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c, t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic (b\u00ed ti\u1ec3u, kh\u00f4 mi\u1ec7ng n\u1eb7ng).<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>X\u1eed tr\u00ed<\/strong><\/span><\/p>\n<p>C\u1ea7n x\u1eed tr\u00ed s\u1edbm, t\u1ed1t nh\u1ea5t trong v\u00f2ng 4 gi\u1edd \u0111\u1ea7u sau khi u\u1ed1ng qu\u00e1 li\u1ec1u.<\/p>\n<p>R\u1eeda d\u1ea1 d\u00e0y, d\u00f9ng than ho\u1ea1t t\u00ednh ho\u1eb7c thu\u1ed1c t\u1ea9y mu\u1ed1i \u0111\u1ec3 h\u1ea1n ch\u1ebf h\u1ea5p thu thu\u1ed1c.<\/p>\n<p>Gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u: N-acetylcystein (NAC) \u0111\u01b0\u1eddng u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch, hi\u1ec7u qu\u1ea3 nh\u1ea5t khi d\u00f9ng trong 10 gi\u1edd \u0111\u1ea7u, nh\u01b0ng v\u1eabn c\u00f3 \u00edch n\u1ebfu s\u1eed d\u1ee5ng trong v\u00f2ng 36 gi\u1edd sau khi u\u1ed1ng paracetamol.<\/p>\n<p>Li\u1ec1u u\u1ed1ng: 140 mg\/kg li\u1ec1u \u0111\u1ea7u, sau \u0111\u00f3 17 li\u1ec1u, m\u1ed7i li\u1ec1u 70 mg\/kg c\u00e1ch nhau 4 gi\u1edd.<\/p>\n<p>N\u1ebfu kh\u00f4ng c\u00f3 NAC, c\u00f3 th\u1ec3 thay th\u1ebf b\u1eb1ng methionin.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3: theo d\u00f5i v\u00e0 duy tr\u00ec ch\u1ee9c n\u0103ng gan, th\u1eadn, h\u00f4 h\u1ea5p, tim m\u1ea1ch, c\u00e2n b\u1eb1ng n\u01b0\u1edbc v\u00e0 \u0111i\u1ec7n gi\u1ea3i.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Pabemin 325 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Pabemin 325 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Pabemin 325 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>Thu\u1ed1c Pabemin 325 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Pabemin 325 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Pabemin 325 c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Pabemin 325 t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Pabemin 325 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/coldacmin-flu\/\">Coldacmin Flu<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol v\u00e0 Clorpheniramin, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam, s\u1ed1t, ho v\u00e0 s\u1ed5 m\u0169i<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/trivacintana\/\">TrivacinTana<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Paracetamol v\u00e0 Clorpheniramin, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Chi nh\u00e1nh c\u00f4ng ty TNHH SX-TM d\u01b0\u1ee3c ph\u1ea9m Th\u00e0nh Nam, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng c\u1ea3m c\u00fam, s\u1ed1t, ho v\u00e0 s\u1ed5 m\u0169i<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Pabemin 325 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/To-huong-dan-su-dung-Pabemin-325-vnras.pdf\">t\u1ea1i \u0111\u00e2<\/a>y. Truy c\u1eadp ng\u00e0y 21 th\u00e1ng 8 n\u0103m 2025<\/li>\n<li>Chua SS, Benrimoj SI, Gordon RD, Williams G (1991). Cardiovascular effects of a chlorpheniramine\/paracetamol combination in hypertensive patients who were sensitive to the pressor effect of pseudoephedrine. Br J Clin Pharmacol. Truy c\u1eadp ng\u00e0y 21 th\u00e1ng 8 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1368368\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1368368\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Pabemin 325 c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t, gi\u1ea3m \u0111au k\u00e8m theo kh\u00e1ng histamin gi\u00fap c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng d\u1ecb \u1ee9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, d\u00f9ng khi s\u1ed1t, c\u1ea3m c\u00fam, ho, s\u1ed5 m\u0169i, ngh\u1eb9t m\u0169i<\/span><\/p>\n","protected":false},"author":1,"featured_media":133946,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-133944","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/133944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=133944"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/133946"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=133944"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=133944"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=133944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}