{"id":132319,"date":"2025-08-14T00:54:41","date_gmt":"2025-08-13T17:54:41","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=132319"},"modified":"2025-08-15T14:57:03","modified_gmt":"2025-08-15T07:57:03","slug":"lipvar-10-dhg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/lipvar-10-dhg\/","title":{"rendered":"Lipvar 10 DHG"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Lipvar 10 DHG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng Ty C\u1ed5 Ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110269923 (S\u0110K c\u0169: VD-30859-18)<\/strong><\/p>\n<h2>Lipvar 10 DHG l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Lipvar 10 DHG<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Atorvastatin (d\u01b0\u1edbi d\u1ea1ng Atorvastatin calcium)&#8230;&#8230;&#8230;.10mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110269923 (S\u0110K c\u0169: VD-30859-18)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 48 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Lipvar 10 DHG<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Atorvastatin \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc v\u00e0 c\u1ea1nh tranh enzym HMG-CoA reductase \u2013 y\u1ebfu t\u1ed1 then ch\u1ed1t trong qu\u00e1 tr\u00ecnh chuy\u1ec3n HMG-CoA th\u00e0nh mevalonat, ti\u1ec1n ch\u1ea5t c\u1ee7a cholesterol. S\u1ef1 \u1ee9c ch\u1ebf n\u00e0y l\u00e0m gi\u1ea3m t\u1ed5ng h\u1ee3p cholesterol t\u1ea1i gan, \u0111\u1ed3ng th\u1eddi t\u0103ng s\u1ed1 l\u01b0\u1ee3ng th\u1ee5 th\u1ec3 LDL \u1edf b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan, t\u1eeb \u0111\u00f3 t\u0103ng thu b\u1eaft v\u00e0 ph\u00e2n h\u1ee7y LDL trong m\u00e1u.<\/p>\n<p>Thu\u1ed1c c\u00f2n gi\u00fap t\u0103ng HDL-C t\u1eeb 5\u201315%, c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 LDL\/HDL v\u00e0 cholesterol to\u00e0n ph\u1ea7n\/HDL. Ngo\u00e0i ra, atorvastatin l\u00e0m gi\u1ea3m triglycerid 10\u201330% th\u00f4ng qua vi\u1ec7c t\u0103ng \u0111\u00e0o th\u1ea3i VLDL c\u00f2n t\u1ed3n d\u01b0 nh\u1edd th\u1ee5 th\u1ec3 LDL. C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y statin l\u00e0m gi\u1ea3m r\u00f5 r\u1ec7t bi\u1ebfn c\u1ed1 m\u1ea1ch v\u00e0nh, gi\u1ea3m t\u1eed vong do tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh m\u1ea1ch v\u00e0nh.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Atorvastatin h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau 1\u20132 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 12%, ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf HMG-CoA tr\u00ean to\u00e0n c\u01a1 th\u1ec3 kho\u1ea3ng 30%.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng c\u1ee7a th\u1ee9c \u0103n: Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 h\u1ea1 lipid.<\/p>\n<p>Th\u1eddi \u0111i\u1ec3m d\u00f9ng: N\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng th\u1ea5p h\u01a1n khi u\u1ed1ng bu\u1ed5i t\u1ed1i so v\u1edbi bu\u1ed5i s\u00e1ng, tuy nhi\u00ean hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u01b0\u01a1ng \u0111\u01b0\u01a1ng.<\/p>\n<p>Ph\u00e2n b\u1ed1: G\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u2265 98%, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh kho\u1ea3ng 381L.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Ch\u1ee7 y\u1ebfu qua CYP3A4 t\u1ea1o c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxyl h\u00f3a v\u00e0 oxy h\u00f3a, v\u1eabn c\u00f2n ho\u1ea1t t\u00ednh v\u00e0 \u0111\u00f3ng g\u00f3p kho\u1ea3ng 70% kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf enzym.<\/p>\n<p>Th\u1ea3i tr\u1eeb: \u0110\u00e0o th\u1ea3i ch\u1ee7 y\u1ebfu qua m\u1eadt, th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 14 gi\u1edd; t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf enzym k\u00e9o d\u00e0i 20\u201330 gi\u1edd.<\/p>\n<h2>Thu\u1ed1c Lipvar 10 DHG \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>T\u0103ng cholesterol to\u00e0n ph\u1ea7n, LDL-C, apolipoprotein B v\u00e0 triglycerid \u1edf b\u1ec7nh nh\u00e2n t\u0103ng cholesterol m\u00e1u nguy\u00ean ph\u00e1t (gia \u0111\u00ecnh d\u1ecb h\u1ee3p t\u1eed ho\u1eb7c kh\u00f4ng) ho\u1eb7c r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p (Fredrickson type IIa, IIb).<\/p>\n<p>T\u0103ng triglycerid m\u00e1u (Fredrickson type IV) kh\u00f4ng \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 v\u1edbi ch\u1ebf \u0111\u1ed9 \u0103n.<\/p>\n<p>Gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n v\u00e0 cholesterol x\u1ea5u (LDL-C) \u1edf b\u1ec7nh nh\u00e2n t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed.<\/p>\n<p>D\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t bi\u1ebfn c\u1ed1 tim m\u1ea1ch: gi\u1ea3m nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5, t\u1eed vong do b\u1ec7nh tim m\u1ea1ch, gi\u1ea3m nhu c\u1ea7u can thi\u1ec7p m\u1ea1ch v\u00e0nh v\u00e0 l\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n x\u01a1 v\u1eefa.<\/p>\n<figure id=\"attachment_132332\" aria-describedby=\"caption-attachment-132332\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-132332\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Lipvar-10-DHG.jpg\" alt=\"Lipvar 10 DHG\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Lipvar-10-DHG.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Lipvar-10-DHG-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Lipvar-10-DHG-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/Lipvar-10-DHG-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-132332\" class=\"wp-caption-text\">Thu\u1ed1c Lipvar 10 DHG gi\u00fap gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n, LDL-C, triglycerid v\u00e0 t\u0103ng HDL-C, qua \u0111\u00f3 h\u1ed7 tr\u1ee3 ph\u00f2ng ng\u1eeba v\u00e0 gi\u1ea3m nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Li\u1ec1u d\u00f9ng c\u00e1 th\u1ec3 h\u00f3a theo n\u1ed3ng \u0111\u1ed9 LDL-C ban \u0111\u1ea7u, m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u00e1p \u1ee9ng. Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u01b0\u1eddng l\u00e0 1 vi\u00ean Lipvar 10\/ng\u00e0y, \u0111i\u1ec1u ch\u1ec9nh sau m\u1ed7i 4 tu\u1ea7n. Li\u1ec1u t\u1ed1i \u0111a: 8 vi\u00ean Lipvar 10\/ng\u00e0y.<\/p>\n<p>T\u0103ng cholesterol nguy\u00ean ph\u00e1t ho\u1eb7c r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p: \u0110a s\u1ed1 ki\u1ec3m so\u00e1t t\u1ed1t v\u1edbi 1 vi\u00ean Lipvar 10\/ng\u00e0y. Hi\u1ec7u qu\u1ea3 th\u1ea5y trong 2 tu\u1ea7n, t\u1ed1i \u0111a sau 4 tu\u1ea7n, duy tr\u00ec khi d\u00f9ng l\u00e2u d\u00e0i.<\/p>\n<p>T\u0103ng cholesterol c\u00f3 t\u00ednh gia \u0111\u00ecnh d\u1ecb h\u1ee3p t\u1eed: B\u1eaft \u0111\u1ea7u 1 vi\u00ean\/ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng d\u1ea7n \u0111\u1ebfn 4 vi\u00ean, t\u1ed1i \u0111a 8 vi\u00ean ho\u1eb7c k\u1ebft h\u1ee3p nh\u1ef1a g\u1eafn acid m\u1eadt.<\/p>\n<p>T\u0103ng cholesterol c\u00f3 t\u00ednh gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed: D\u00f9ng t\u1eeb 1\u20138 vi\u00ean\/ng\u00e0y, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p h\u1ea1 lipid kh\u00e1c n\u1ebfu c\u1ea7n.<\/p>\n<p>Ph\u00f2ng b\u1ec7nh tim m\u1ea1ch: Li\u1ec1u th\u01b0\u1eddng d\u00f9ng l\u00e0 1 vi\u00ean Lipvar 10\/ng\u00e0y, c\u00f3 th\u1ec3 c\u1ea7n li\u1ec1u cao h\u01a1n theo m\u1ee5c ti\u00eau LDL-C.<\/p>\n<p>Suy th\u1eadn: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Suy gan: Th\u1eadn tr\u1ecdng, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh n\u1ebfu b\u1ec7nh gan ti\u1ebfn tri\u1ec3n.<\/p>\n<p>Ng\u01b0\u1eddi \u226570 tu\u1ed5i: Hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng ng\u01b0\u1eddi tr\u1ebb.<\/p>\n<p>Tr\u1ebb 2\u201310 tu\u1ed5i (r\u1ed1i lo\u1ea1n lipid nghi\u00eam tr\u1ecdng): D\u01b0\u1edbi gi\u00e1m s\u00e1t chuy\u00ean gia. Kh\u1edfi \u0111\u1ea7u 1 vi\u00ean Lipvar 10mg\/ng\u00e0y, t\u1ed1i \u0111a 2 vi\u00ean\/ng\u00e0y.<\/p>\n<p>Kh\u00f4ng d\u00f9ng cho tr\u1ebb &lt;10 tu\u1ed5i.<\/p>\n<p>Ho\u1eb7c d\u00f9ng theo ch\u1ec9 \u0111\u1ecbnh b\u00e1c s\u0129.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>C\u00f3 th\u1ec3 u\u1ed1ng <strong>vi\u00ean n\u00e9n Lipvar 10 DHG<\/strong> b\u1ea5t k\u1ef3 l\u00fac n\u00e0o trong ng\u00e0y, c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<p>Tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb v\u1edbi atorvastatin, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh l\u1ed1i s\u1ed1ng nh\u01b0 \u0103n u\u1ed1ng h\u1ee3p l\u00fd, t\u1eadp luy\u1ec7n, gi\u1ea3m c\u00e2n (n\u1ebfu th\u1eeba c\u00e2n) v\u00e0 ki\u1ec3m so\u00e1t b\u1ec7nh n\u1ec1n. B\u1ec7nh nh\u00e2n n\u00ean duy tr\u00ec ch\u1ebf \u0111\u1ed9 \u0103n gi\u1ea3m cholesterol trong su\u1ed1t qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Lipvar 10 DHG trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi atorvastatin ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u00f3 trong Lipvar 10 DHG<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh gan ti\u1ebfn tri\u1ec3n ho\u1eb7c ng\u01b0\u1eddi c\u00f3 men transaminase t\u0103ng k\u00e9o d\u00e0i v\u00f4 c\u0103n<\/p>\n<p>Men gan t\u0103ng &gt; 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>\u0110ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng tipranavir + ritonavir ho\u1eb7c telaprevir.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai, cho con b\u00fa ho\u1eb7c ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n kh\u00f4ng \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai an to\u00e0n.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ki\u1ec3m so\u00e1t lipid m\u00e1u k\u1ebft h\u1ee3p ch\u1ebf \u0111\u1ed9 \u0103n, gi\u1ea3m c\u00e2n, luy\u1ec7n t\u1eadp tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c.<\/p>\n<p>\u0110\u1ecbnh k\u1ef3 ki\u1ec3m tra lipid v\u00e0 men gan, \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo \u0111\u00e1p \u1ee9ng.<\/p>\n<p>Theo d\u00f5i men gan tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb v\u00e0 khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng; gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng thu\u1ed1c n\u1ebfu men ALT\/AST &gt; 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>C\u00e2n nh\u1eafc nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 xu\u1ea5t huy\u1ebft khi d\u00f9ng li\u1ec1u cao (80mg) \u1edf b\u1ec7nh nh\u00e2n t\u1eebng b\u1ecb \u0111\u1ed9t qu\u1ef5 xu\u1ea5t huy\u1ebft.<\/p>\n<p>Theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1ec1 c\u01a1, x\u00e9t nghi\u1ec7m CK khi c\u1ea7n; nguy c\u01a1 ti\u00eau c\u01a1 v\u00e2n t\u0103ng khi ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4, gemfibrozil, fibrat ho\u1eb7c m\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1ng virus HIV.<\/p>\n<p>Ng\u1eebng thu\u1ed1c n\u1ebfu xu\u1ea5t hi\u1ec7n vi\u00eam ph\u1ed5i k\u1ebd.<\/p>\n<p>Theo d\u00f5i \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng (BMI &gt; 30, t\u0103ng huy\u1ebft \u00e1p, t\u0103ng triglycerid, glucose m\u00e1u 5,6\u20136,9 mmol\/L).<\/p>\n<p>Kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p lactose, thi\u1ebfu men lactase ho\u1eb7c r\u1ed1i lo\u1ea1n h\u1ea5p thu glucose\u2013galactose.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: C\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n vi\u00eam m\u0169i h\u1ecdng, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft; \u0111au h\u1ecdng, ch\u1ea3y m\u00e1u cam; r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a nh\u01b0 ti\u00eau ch\u1ea3y, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n; \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd, m\u1ea5t ng\u1ee7, suy nh\u01b0\u1ee3c; \u0111au c\u01a1, \u0111au kh\u1edbp, co th\u1eaft c\u01a1, \u0111au l\u01b0ng.<\/p>\n<p>\u00cdt g\u1eb7p: C\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, t\u0103ng c\u00e2n, ch\u00e1n \u0103n; \u00e1c m\u1ed9ng, m\u1ea5t ng\u1ee7; ch\u00f3ng m\u1eb7t, d\u1ecb c\u1ea3m, r\u1ed1i lo\u1ea1n c\u1ea3m gi\u00e1c, suy gi\u1ea3m tr\u00ed nh\u1edb; nh\u00ecn m\u1edd, \u00f9 tai; n\u00f4n, \u0111au b\u1ee5ng, vi\u00eam t\u1ee5y, \u1ee3 h\u01a1i; vi\u00eam gan; m\u00e0y \u0111ay, ng\u1ee9a, ph\u00e1t ban, r\u1ee5ng t\u00f3c; \u0111au c\u1ed5, m\u1ecfi c\u01a1.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Gi\u1ea3m ti\u1ec3u c\u1ea7u; r\u1ed1i lo\u1ea1n th\u1ecb l\u1ef1c, th\u1ea7n kinh ngo\u1ea1i bi\u00ean; t\u1eafc m\u1eadt, ph\u00f9 m\u1ea1ch, b\u1ec7nh c\u01a1, ti\u00eau c\u01a1 v\u00e2n, tho\u00e1t v\u1ecb, h\u1ed9i ch\u1ee9ng Stevens\u2013Johnson<\/p>\n<p>R\u1ea5t hi\u1ebfm: C\u00f3 th\u1ec3 g\u00e2y s\u1ed1c ph\u1ea3n v\u1ec7, m\u1ea5t th\u00ednh gi\u00e1c, suy gan, ch\u1ee9ng to v\u00fa \u1edf nam gi\u1edbi.<\/p>\n<p>Kh\u00e1c: M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p b\u1ecb suy gi\u1ea3m nh\u1eadn th\u1ee9c (nh\u01b0 l\u00fa l\u1eabn, m\u1ea5t tr\u00ed nh\u1edb), t\u0103ng HbA1c, t\u0103ng men transaminase.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Nh\u00f3m \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh (nh\u01b0 cyclosporin, clarithromycin, delavirdin, ketoconazol, voriconazol, itraconazol, posaconazol, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf protease HIV g\u1ed3m ritonavir, lopinavir, atazanavir, indinavir, darunavir\u2026): l\u00e0m t\u0103ng nhi\u1ec1u n\u1ed3ng \u0111\u1ed9 atorvastatin trong m\u00e1u, n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p; n\u1ebfu b\u1eaft bu\u1ed9c, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u kh\u1edfi \u0111\u1ea7u v\u00e0 t\u1ed1i \u0111a, \u0111\u1ed3ng th\u1eddi theo d\u00f5i s\u00e1t.<\/p>\n<p>Nh\u00f3m \u1ee9c ch\u1ebf CYP3A4 m\u1ee9c \u0111\u1ed9 v\u1eeba (erythromycin, diltiazem, verapamil, fluconazol): c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 atorvastatin, t\u0103ng nguy c\u01a1 b\u1ec7nh c\u01a1; khi d\u00f9ng chung c\u1ea7n gi\u1ea3m li\u1ec1u v\u00e0 theo d\u00f5i.<\/p>\n<p>Nh\u00f3m c\u1ea3m \u1ee9ng CYP3A4 (efavirenz, rifampin\u2026): c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 atorvastatin; v\u1edbi rifampin n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi atorvastatin \u0111\u1ec3 h\u1ea1n ch\u1ebf gi\u1ea3m n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf protein v\u1eadn chuy\u1ec3n (nh\u01b0 cyclosporin): l\u00e0m t\u0103ng h\u1ea5p thu atorvastatin, c\u1ea7n gi\u1ea3m li\u1ec1u v\u00e0 theo d\u00f5i n\u1ebfu ph\u1ed1i h\u1ee3p.<\/p>\n<p>Gemfibrozil, c\u00e1c fibrat, ezetimib: khi d\u00f9ng c\u00f9ng c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 b\u1ec7nh c\u01a1, k\u1ec3 c\u1ea3 ti\u00eau c\u01a1 v\u00e2n; c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd.<\/p>\n<p>Colestipol: l\u00e0m gi\u1ea3m kho\u1ea3ng 25% n\u1ed3ng \u0111\u1ed9 atorvastatin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a, nh\u01b0ng hi\u1ec7u qu\u1ea3 gi\u1ea3m lipid m\u00e1u t\u0103ng khi ph\u1ed1i h\u1ee3p.<\/p>\n<p>Acid fusidic: ph\u1ed1i h\u1ee3p c\u00f3 th\u1ec3 g\u00e2y v\u1ea5n \u0111\u1ec1 v\u1ec1 c\u01a1, n\u00ean theo d\u00f5i ho\u1eb7c t\u1ea1m ng\u01b0ng atorvastatin khi c\u1ea7n.<\/p>\n<p>Colchicin: \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o b\u1ec7nh c\u01a1 khi d\u00f9ng c\u00f9ng atorvastatin, c\u1ea7n th\u1eadn tr\u1ecdng.<\/p>\n<p>Digoxin: ph\u1ed1i h\u1ee3p l\u00e0m t\u0103ng nh\u1eb9 n\u1ed3ng \u0111\u1ed9 digoxin, c\u1ea7n theo d\u00f5i.<\/p>\n<p>Thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng: d\u00f9ng c\u00f9ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 norethindron v\u00e0 ethinyl estradiol.<\/p>\n<p>Warfarin: li\u1ec1u cao atorvastatin (80 mg\/ng\u00e0y) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nh\u1eb9 th\u1eddi gian prothrombin trong 4 ng\u00e0y \u0111\u1ea7u, tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng trong 15 ng\u00e0y; n\u00ean ki\u1ec3m tra th\u1eddi gian prothrombin tr\u01b0\u1edbc v\u00e0 trong khi d\u00f9ng chung.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng mang thai: c\u1ea7n \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai ph\u00f9 h\u1ee3p khi \u0111ang \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai: ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong su\u1ed1t thai k\u1ef3; ch\u01b0a c\u00f3 d\u1eef li\u1ec7u an to\u00e0n tr\u00ean ng\u01b0\u1eddi; nghi\u00ean c\u1ee9u \u0111\u1ed9ng v\u1eadt cho th\u1ea5y thu\u1ed1c g\u00e2y \u0111\u1ed9c t\u00ednh sinh s\u1ea3n v\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 mevalonat c\u1ee7a thai. Ng\u01b0ng d\u00f9ng khi x\u00e1c \u0111\u1ecbnh ho\u1eb7c nghi ng\u1edd c\u00f3 thai.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: ch\u01b0a r\u00f5 thu\u1ed1c c\u00f3 ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng; tr\u00ean chu\u1ed9t, atorvastatin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 trong s\u1eefa. Do nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u ho\u1eb7c ch\u00f3ng m\u1eb7t, c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c l\u00e0m vi\u1ec7c v\u1edbi m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 bi\u1ec7n ph\u00e1p \u0111\u1eb7c hi\u1ec7u cho tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u. X\u1eed tr\u00ed ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 c\u1ea7n thi\u1ebft. Do atorvastatin g\u1eafn m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, th\u1ea9m t\u00e1ch m\u00e1u kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng lo\u1ea1i b\u1ecf \u0111\u00e1ng k\u1ec3 thu\u1ed1c.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>Gi\u1eef Lipvar 10 DHG \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/p>\n<p>Kh\u00f4ng \u0111\u1ec3 Lipvar 10 DHG trong t\u1ea7m v\u1edbi tr\u1ebb em<\/p>\n<p>Kh\u00f4ng s\u1eed d\u1ee5ng Lipvar 10 DHG khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Lipvar 10 DHG nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/atorvastatin-10mg-tv-pharm\/\">Atorvastatin 10mg TV.Pharm<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Atorvastatin 10mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m TV. Pharm, \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/atorvastatin-10-khapharco\/\">Atorvastatin 10 Khapharco<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Atorvastatin 10mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Kh\u00e1nh Ho\u00e0, \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Lipvar 10 DHG \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/08\/To-huong-dan-su-dung-Lipvar-10-DHG-vnras.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 8 n\u0103m 2025<\/li>\n<li>Adams SP, Tsang M, Wright JM. Lipid-lowering efficacy of atorvastatin (2015). Cochrane Database Syst Rev. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 8 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6464917\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6464917\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Lipvar 10 DHG gi\u00fap gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n, LDL-C, triglycerid v\u00e0 t\u0103ng HDL-C, qua \u0111\u00f3 h\u1ed7 tr\u1ee3 ph\u00f2ng ng\u1eeba v\u00e0 gi\u1ea3m nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch.<\/span><\/p>\n","protected":false},"author":1,"featured_media":132322,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-132319","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/132319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=132319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/132322"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=132319"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=132319"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=132319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}